A barrier repair composition for activating cellular energy and its application

Abstract

This invention relates to a barrier repair composition that activates cellular energy and its application. The composition comprises the following components: niacinamide, wheat germ extract, oat β-glucan, and camellia oleifera flower extract. These four components work synergistically to form a full-chain barrier repair system of "energy supply (niacinamide) - autophagy clearance (wheat germ extract) - structural strengthening (β-glucan) - oxidative defense (camellia oleifera flower extract)". This system breaks through the limitations of traditional skin care products that only supplement lipids or provide antioxidants, rebuilds the dynamic balance of lipids from the root of cellular metabolism, and has certain skin smoothing and anti-aging effects.

Description

Technical Field

[0001] This invention relates to the technical field of skincare products, specifically to a barrier repair composition that activates cellular energy and its application. Background Technology

[0002] The core characteristic of skin barrier damage in sensitive skin lies in insufficient synthesis or structural disorder of the stratum corneum lipid matrix (such as ceramides, cholesterol, and free fatty acids), leading to increased transepidermal water loss (TEWL), easier penetration of external stimuli, and triggering inflammatory responses. Studies have shown that the differentiation of keratinocytes and lipid synthesis in the skin are highly dependent on intracellular energy metabolism homeostasis. Mitochondria, as the core unit of energy supply, generate ATP through oxidative phosphorylation and provide key raw materials for the synthesis of lipid precursors (such as acetyl-CoA and NADPH). Furthermore, damaged mitochondria accumulated in sensitive skin due to external stimuli (such as ultraviolet radiation and chemical allergens) continuously release reactive oxygen species (ROS), inducing lipid peroxidation and inhibiting the function of lipid synthesis-related enzymes, forming a vicious cycle of "energy deficiency - oxidative damage - lipid deficiency." Mitophagy, by selectively clearing dysfunctional mitochondria, can effectively reduce ROS production, maintain mitochondrial network health, and thus provide a stable metabolic environment for lipid synthesis. Therefore, by synergistically activating mitochondrial energy metabolism and inducing mitophagy, not only can the energy and substrate supply required for lipid synthesis be directly increased, but lipid structure stability can also be optimized by clearing oxidative damage sources, thereby rebuilding the dynamic balance of barrier lipids at the molecular level and restoring the healthy barrier state of sensitive skin.

[0003] Current repair strategies for sensitive skin barrier damage, especially in the skincare field, generally focus on exogenously supplementing barrier lipids (such as ceramides and cholesterol) or strengthening physical sealing to reduce moisture loss. While these methods can improve epidermal dryness in the short term, they fail to address the core mechanism of lipid deficiency—the decline in the autonomous synthesis capacity of epidermal cells due to energy metabolism disorders. Their limitation lies in simply attributing lipid deficiency to component loss, ignoring the imbalance in the regulation of endogenous cellular biosynthetic pathways. Mitochondria, as the core source of lipid precursors (such as acetyl-CoA and NADPH) and ATP, directly restrict key steps such as fatty acid chain elongation and ceramide assembly when their function declines. However, current technologies rarely restore the cell's "lipid factory" function by activating mitochondrial energy metabolism. Furthermore, the continuous accumulation of damaged mitochondria not only exacerbates the energy crisis but also triggers lipid peroxidation by releasing excessive ROS, leading to unstable or even decomposed nascent lipid structures. Currently available products lack interventions for mitochondrial quality control (such as inducing mitophagy to clear damaged units), resulting in superficial and unsustainable repair effects. Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide a barrier repair composition that activates cellular energy and its application. The raw material components in the composition work synergistically to promote lipid synthesis by deeply stimulating cellular energy and autophagy of damaged mitochondria, thereby achieving the effect of barrier repair.

[0005] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0006] In a first aspect, the present invention provides a barrier repair composition for activating cellular energy, comprising the following components: nicotinamide, wheat germ extract, oat β-glucan and camellia oleracea extract, wherein the weight ratio of nicotinamide, wheat germ extract, oat β-glucan and camellia oleracea extract is (0.1-5):(0.1-3):(0.1-3):(0.1-5).

[0007] Nicotinamide (a derivative of vitamin B3) is a water-soluble vitamin that plays a central role in energy metabolism. It works by increasing intracellular NAD+ levels. + At elevated levels, niacinamide activates mitochondrial oxidative phosphorylation, enhancing ATP production efficiency and providing an energy basis for the synthesis of skin barrier lipids (such as ceramides and cholesterol). Furthermore, niacinamide promotes dermal microcirculation, increasing the supply of lipid precursors (such as acetyl-CoA), indirectly supporting lipid metabolism. In skincare products, its antioxidant properties can reduce oxidative stress damage to the skin, while improving uneven skin tone, enhancing barrier function, and delaying photoaging.

[0008] Wheat germ extract is derived from the germ of the wheat plant (Triticum aestivum L.), belonging to the genus Triticum in the Poaceae family. It is rich in protein, vitamin E, B vitamins, and minerals. Its core active ingredients include spermidine and polysaccharides, exhibiting significant antioxidant and cell repair functions. As an autophagy inducer, it can reduce the inhibitory effect of reactive oxygen species (ROS) on lipid synthases by clearing damaged mitochondria, maintaining mitochondrial network health, and thus ensuring sustained energy output.

[0009] Oat β-glucan, extracted from the endosperm and aleurone layer of *Avena sativa*, a plant belonging to the genus *Avena* of the Poaceae family, is a water-soluble polysaccharide linked by β-glycosidic bonds. Its molecular structure creates a highly viscous environment, forming a biomimetic hydration film on the skin surface and reducing transepidermal water loss. By activating keratinocyte differentiation, it accelerates the secretion of lipids by lamellar bodies, strengthening the skin barrier structure. Furthermore, this component has immunomodulatory effects, enhancing skin microcirculation and mitochondrial biosynthesis, synergistically forming a positive feedback loop in energy metabolism with niacinamide, while also possessing anti-inflammatory and soothing effects.

[0010] Camellia chrysantha extract, derived from the Camellia genus of the Theaceae family, is known as the "giant panda of the plant kingdom" and is rich in tea polyphenols, flavonoids, saponins, and polysaccharides. Its polyphenols and flavonoids inhibit lipid peroxidation by scavenging free radicals, protecting newly formed lipids from oxidative damage. Its anti-inflammatory properties alleviate barrier damage caused by excessive activation of inflammatory factors, while simultaneously repairing damaged mitochondrial function. This ingredient, in skincare products, combines antioxidant, anti-aging, and microcirculation-promoting effects, and is commonly used to improve skin elasticity, reduce inflammation, and support overall barrier health.

[0011] Preferably, the weight ratio of nicotinamide, wheat germ extract, oat β-glucan and golden camellia flower extract is (1-3):(0.1-1):(0.5-2):(0.5-2).

[0012] More preferably, the weight ratio of nicotinamide, wheat germ extract, oat β-glucan and Camellia chrysantha extract is (1-2):(0.6-1):(0.8-1):(0.5-1).

[0013] Secondly, the present invention provides the application of the barrier repair composition for activating cellular energy described in the first aspect in the preparation of skin care products.

[0014] Preferably, the skin care product is any one of toner, lotion, cream, mask, serum or spray, and the amount of the composition added is 0.5%-5% of the total weight of the skin care product.

[0015] Thirdly, the present invention provides an essence comprising the following ingredients by weight percentage: 0.5%-5% of the composition described in the first aspect, 0.05%-0.3% of a thickener, 0.5%-10% of a moisturizer, 0.5%-5% of a preservative, 0.01%-0.3% of a pH adjuster, and 0.01%-1% of a fragrance, with the balance being deionized water.

[0016] Preferably, the thickener comprises at least one selected from xanthan gum, carbomer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, sclerotium gum, and cetyl alcohol. More preferably, it is carbomer U30.

[0017] Preferably, the moisturizer comprises at least one of allantoin, sodium polyacrylate, hydrogenated lecithin, betaine, β-glucan, trehalose, caprylyl glycol, dipropylene glycol, hydrolyzed sodium hyaluronate, 1,2-butanediol, glycerin, budding stalk polysaccharide, and ceramide. More preferably, the moisturizer is a composition of glycerin, 1,2-butanediol, and allantoin.

[0018] Preferably, the pH adjuster includes at least one selected from arginine, tromethamine, and disodium EDTA. More preferably, the pH adjuster is arginine.

[0019] Preferably, the preservative includes at least one selected from 1,2-propanediol, 1,2-hexanediol, and p-hydroxyacetophenone. More preferably, the preservative is 1,2-hexanediol and p-hydroxyacetophenone.

[0020] Fourthly, the present invention provides a method for preparing the essence in the third aspect, comprising the following steps:

[0021] S1. Mix the humectant, thickener and part of the deionized water, homogenize at 75-85℃, then add the preservative and stir evenly to obtain the mixture.

[0022] S2. When the temperature drops to 35-45℃, add each component of the composition, fragrance and remaining deionized water to the mixture obtained in step S1, stir evenly, and finally add pH adjuster to adjust pH to obtain the essence.

[0023] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0024] The composition of this invention includes nicotinamide, wheat germ extract, oat β-glucan, and camellia flower extract. Nicotinamide, as a core energy metabolism regulator, increases intracellular nicotinamide adenine dinucleotide (NAD). +Activating mitochondrial oxidative phosphorylation at the PINK1 level significantly enhances ATP production efficiency, providing an energy basis for the synthesis of barrier lipids such as ceramides and cholesterol. Simultaneously, it directly promotes lipid synthesis by increasing the supply of lipid precursors such as acetyl-CoA through promoting dermal microcirculation. Wheat germ extract, as an autophagy inducer, targets and clears damaged mitochondria by activating the PINK1 / Parkin pathway, reducing the inhibition of lipid synthases by ROS production, while enhancing autophagosome formation efficiency and maintaining mitochondrial network health to ensure continuous energy output. Oat β-glucan promotes keratinocyte differentiation by activating TLR2 receptors, accelerates lamellar body lipid secretion to improve barrier structure, and its polysaccharide chains can also form a biomimetic hydration membrane to reduce transepidermal water loss. It also enhances mitochondrial biosynthesis, forming a positive feedback loop of energy metabolism with nicotinamide. Camellia japonica flower extract is rich in tea polyphenols and flavonoids, which inhibit the lipid peroxidation chain reaction by scavenging free radicals, protecting newly formed lipids from oxidative damage. Its anti-inflammatory properties can reduce barrier damage caused by excessive activation of the TRPV1 channel and also activate and repair mitochondrial function. The four components work together to form a complete barrier repair system consisting of "energy supply (niacinamide) - autophagy cleansing (wheat germ extract) - structural reinforcement (β-glucan) - oxidative defense (camellia extract)," breaking through the limitations of traditional skincare products that only supplement lipids or provide antioxidants. It rebuilds the dynamic balance of lipids from the root of cell metabolism and has certain skin-smoothing and anti-aging effects. Attached Figure Description

[0025] Figure 1 Flowchart for facial sebum extraction from volunteers;

[0026] Figure 2 This is a comparison chart of the use of the serum on day 0 and day 28 in Application Example 1 and Comparative Application Example 5 (blank control group). Detailed Implementation

[0027] To better illustrate the purpose, technical solution, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0028] The sources of the raw materials used in the following examples and comparative examples are as follows:

[0029] Nicotinamide: Manufacturer: BASF Chemical Company.

[0030] Wheat germ extract: manufactured by Shaanxi Fuheng Biotechnology Co., Ltd.

[0031] Oat β-glucan: Manufacturer is Beijing Dongfang Miaosen Biotechnology Co., Ltd., brand name is Miaokexiu.

[0032] Golden Camellia Flower Extract: Manufacturer is Ximuyuan (Xiamen) Biotechnology Co., Ltd.

[0033] Unless otherwise specified, all other materials and reagents used in the examples are commercially available.

[0034] Example 1

[0035] A barrier repair composition for activating cellular energy comprises nicotinamide, wheat germ extract, oat beta-glucan, and camellia chrysantha extract in a weight ratio of 1.5:0.8:0.9:0.7, wherein the total weight of the nicotinamide, wheat germ extract, oat beta-glucan, and camellia chrysantha extract is 100 parts.

[0036] Example 2

[0037] A barrier repair composition for activating cellular energy comprises nicotinamide, wheat germ extract, oat beta-glucan, and camellia chrysantha extract in a weight ratio of 1:0.6:1:1, wherein the total weight of the nicotinamide, wheat germ extract, oat beta-glucan, and camellia chrysantha extract is 100 parts.

[0038] Example 3

[0039] A barrier repair composition for activating cellular energy comprises nicotinamide, wheat germ extract, oat beta-glucan, and camellia chrysantha extract in a weight ratio of 2:1:0.8:0.5, wherein the total weight of the nicotinamide, wheat germ extract, oat beta-glucan, and camellia chrysantha extract is 100 parts.

[0040] Example 4

[0041] A barrier repair composition for activating cellular energy comprises nicotinamide, wheat germ extract, oat beta-glucan, and camellia chrysantha extract in a weight ratio of 1:0.1:0.5:2, wherein the total weight of the nicotinamide, wheat germ extract, oat beta-glucan, and camellia chrysantha extract is 100 parts.

[0042] Example 5

[0043] A barrier repair composition for activating cellular energy comprises nicotinamide, wheat germ extract, oat beta-glucan, and camellia chrysantha extract in a weight ratio of 3:1:2:0.5, wherein the total weight of the nicotinamide, wheat germ extract, oat beta-glucan, and camellia chrysantha extract is 100 parts.

[0044] Example 6

[0045] A barrier repair composition for activating cellular energy comprises nicotinamide, wheat germ extract, oat beta-glucan, and camellia chrysantha flower extract in a weight ratio of 5:0.1:3:0.1, wherein the total weight of the nicotinamide, wheat germ extract, oat beta-glucan, and camellia chrysantha flower extract is 100 parts.

[0046] Example 7

[0047] A barrier repair composition for activating cellular energy comprises nicotinamide, wheat germ extract, oat beta-glucan, and camellia chrysantha extract in a weight ratio of 0.1:3:0.1:5, wherein the total weight of the nicotinamide, wheat germ extract, oat beta-glucan, and camellia chrysantha extract is 100 parts.

[0048] Comparative Example 1

[0049] The difference between Comparative Example 1 and Example 1 is that nicotinamide was not added to the composition, and wheat germ extract, oat β-glucan and camellia flower extract in a weight ratio of 0.8:0.9:0.7 were used to make up for the missing amount.

[0050] Comparative Example 2

[0051] The difference between Comparative Example 2 and Example 1 is that wheat germ extract was not added to the composition, and nicotinamide, oat β-glucan and camellia flower extract in a weight ratio of 1.5:0.9:0.7 were used to make up for the missing amount.

[0052] Comparative Example 3

[0053] The difference between Comparative Example 3 and Example 1 is that oat β-glucan was not added to the composition, and nicotinamide, wheat germ extract and camellia flower extract in a weight ratio of 1.5:0.8:0.7 were used to make up for the missing amount.

[0054] Comparative Example 4

[0055] The difference between Comparative Example 4 and Example 1 is that Camellia chrysantha extract was not added to the composition, and nicotinamide, wheat germ extract and oat β-glucan in a weight ratio of 1.5:0.8:0.9 were used to make up for the missing amount.

[0056] Test Example 1: Detection of cellular energy ATP synthesis capacity and autophagy capacity

[0057] The compositions of Examples 1-7 and Comparative Examples 1-4 were set as 11 test sample groups, and the experiments were carried out according to the following steps:

[0058] Human keratinocytes (HaCaT) were revived (Guangzhou Genio Biotechnology Co., Ltd.). The test conditions were: incubator temperature 37±1℃, humidity 90±5%, carbon dioxide 5±1% (v / v). Cells were cultured and treated according to groups, followed by testing, specifically estrogen receptor 2 (ESR2) expression. The test method is as follows:

[0059] (1) The cell suspension was seeded into a 96-well cell culture plate at a density of 2000 cells / well. 100 μL of DMEM high glucose culture medium (Gibco) containing 10% fetal bovine serum was added to each well and cultured for 24 h.

[0060] (2) Sample feeding: only 100 μL of culture medium was added to the blank control group, and 100 μL of culture medium containing 0.1 wt% of the composition test sample was added to each sample group, and the samples were cultured for 48 h.

[0061] (3) Use a commercially available kit to test the intracellular ATP content (MedChemExpress, catalog number: HY-K0314). Measure the intracellular ATP content using bioluminescence method. Calculate the ATP enhancement rate according to the following formula. The higher the enhancement rate, the better the cell energy activation effect.

[0062] (4) The number of autophagosomes in cells was determined by fluorescent labeling using an autophagy detection kit (Abcam, catalog number: ab139484). The autophagy capacity was determined by calculating the autophagosome increase rate. The higher the autophagosome increase rate, the better the cell's autophagy capacity.

[0063] The calculation formula is as follows:

[0064] ATP increase rate (%) = |(ATP content) 样品组 -ATP content 空白对照组 )| / ATP content 空白对照组 ×100%.

[0065] Autophagosome increase rate (%) = |(number of autophagosomes) 样品组 - Number of autophagosomes 空白对照组 )| / Number of autophagosomes 空白对照组 ×100%.

[0066] Table 1. ATP enhancement rate and autophagosome increase rate of each barrier repair composition.

[0067] Group ATP increase rate / % Autophagosome increase rate / % Example 1 262.67 403.94 Example 2 243.23 384.86 Example 3 245.14 386.53 Example 4 237.36 368.94 Example 5 238.02 370.01 Example 6 231.32 330.74 Example 7 229.90 343.85 Comparative Example 1 79.23 90.93 Comparative Example 2 83.47 61.05 Comparative Example 3 91.38 62.65 Comparative Example 4 94.94 64.21

[0068] This test directly verifies the energy supply-autophagy clearance mechanism of the composition by detecting the amount of ATP produced by keratinocytes and the number of autophagy markers, autophagy bodies. By promoting skin cell energy, the skin can autonomously complete its metabolism and repair the skin lipid barrier.

[0069] As shown in Table 1, the data from Example 1 and Comparative Examples 1-4 indicate that the composition of Example 1, which uses four components—nicotinamide, wheat germ extract, oat β-glucan, and camellia chrysanthemi extract—significantly increased the ATP enhancement rate and autophagy increase rate of keratinocytes compared to the compositions of Comparative Examples 1-4. This suggests that the four components—nicotinamide, wheat germ extract, oat β-glucan, and camellia chrysanthemi extract—have a synergistic effect. They promote lipid synthesis by deeply stimulating cellular energy and autophagy in damaged mitochondria, thereby achieving a barrier repair effect.

[0070] Based on the data from Examples 1-7, it can be seen that when the weight ratio of nicotinamide, wheat germ extract, oat β-glucan and Camellia chrysantha extract is (1-2):(0.6-1):(0.8-1):(0.5-1), the composition is more effective in promoting the production of ATP and autophagosomes in keratinocytes.

[0071] Application Example 1-7 and Comparative Application Example 1-4

[0072] The compositions of Examples 1-7 and Comparative Examples 1-4 were added to the serum at a concentration of 3 wt% to obtain the serums of Application Examples 1-7 and Comparative Application Examples 1-4. The formulations are shown in Table 2.

[0073] The preparation methods of the serums used in Application Examples 1-7 and Comparative Application Examples 1-4 include the following steps:

[0074] The preparation method of the serum includes the following steps:

[0075] S1. Mix the humectant, thickener and 1 / 2 volume of deionized water, homogenize at 80°C, then add the preservative and stir until homogeneous to obtain the mixture.

[0076] S2. After the temperature drops to 40°C, add the components of the composition, fragrance and remaining deionized water to the mixture obtained in step S1, stir evenly, and finally add pH adjuster to adjust the pH to 6 to obtain the essence.

[0077] Table 2. Serum formulations for Application Examples 1-7 and Comparative Application Examples 1-4.

[0078]

[0079] Comparative Application Example 5

[0080] In contrast, the essence in Application Example 5 was prepared without the addition of the composition, using an equal amount of deionized water instead of the composition, and the preparation method was the same as in Application Example 1.

[0081] Test Example 2: Serum Efficacy Test

[0082] This test case verifies the effect of the serums used in Examples 1-7 and the control examples 1-5 on improving facial barrier damage. The experimental data are shown in Table 3.

[0083] Select individuals aged 18-45 with noticeable facial redness and skin barrier damage (TEWL value ≥20g / h / m). 2 Ninety-six volunteers participated. The day before the visit, volunteers washed their faces without applying any skincare products. On the day of the visit, they washed their faces with water without applying any products and sat quietly for 20 minutes in an air-conditioned room with a temperature of 21±1℃ and humidity of 50±10%. Samples were taken from the forehead using 3M textured easy-tear tape. Facial imaging was performed using Visia-CR, and image analysis was conducted on the red area images obtained under cross-polarized light to obtain the quantitative index, red area analysis a* value. A transdermal moisture loss probe was used... The TM Hex (Courage + Khazaka) test was used to assess initial facial TEWL values. Subjects were randomly assigned to 12 groups of 8. One mL of the serum from Application Examples 1-7 and the control application examples 1-5 was applied to the entire face twice daily, morning and evening. Forehead oil was sampled again at 7 days (short-term) and 28 days (long-term), and a* values ​​were analyzed and TEWL values ​​were measured.

[0084] like Figure 1 The procedure shown involves cutting skin keratin sampling patches from volunteers at days 0, 7, and 28 into 1-2mm pieces. 2 Lipids on the patches were extracted by sonication for 20 minutes (40 kHz, 300 W) using 20 times the volume of ethanol containing 0.025% butylated hydroxytoluene. After sonication, the mixture was centrifuged at 3000-5000 rpm for 5-10 minutes, and the supernatant was collected. The supernatant was further extracted with 1 volume of ethyl acetate using liquid-liquid extraction to remove other impurities. The upper layer was then rotary evaporated at 50°C and 250 rpm to remove ethanol and residual ethyl acetate, yielding the sebum extract. The extract was dissolved in a mixture of acetone / methanol / isopropanol (40 / 40 / 20 v / v / v) to a concentration of 5 mg / mL and stored at -80°C. Lipid peroxide (LPO) levels in each group were determined using a detection kit manufactured by Nanjing Jiancheng (catalog number BC5240).

[0085] The calculation formula is as follows:

[0086] a* value improvement rate = |(a* value) 使用前 -a* value 使用后 )| / a* value ×100% before use;

[0087] TEWL value improvement rate = |(TEWL value) 使用后 -TEWL value 使用前 )| / TEWL value 使用前 ×100%;

[0088] LPO inhibition rate = |(LPO 使用前 -LPO 使用后 )| / LPO before use ×100%.

[0089] Table 3. Improvement rates of a* value, TEWL value, and LPO inhibition rate for each group of serums.

[0090]

[0091]

[0092] The soothing effect of the application example on facial erythema is represented by the a* value improvement rate, the repair effect on barrier damage is represented by the TEWL value improvement rate, and the inhibition effect on lipid peroxide (LPO) is represented by the LPO inhibition rate. The higher the a* value improvement rate and TEWL value improvement rate, the better the effect of the application example on soothing facial erythema and repairing the barrier. The higher the LPO inhibition rate, the better the effect of the application example on clearing oxidized lipids and the stronger the corresponding sebum optimization ability.

[0093] As shown in Table 3, the data from Application Example 1 and Comparative Application Examples 1-4 indicate that the composition of Example 1, which uses four ingredients—nicotinamide, wheat germ extract, oat β-glucan, and camellia chrysantha extract—significantly improves the soothing effect on facial erythema, the repair effect on barrier damage, and the removal effect on oxidized lipids compared to the compositions of Comparative Examples 1-4. This demonstrates that the four ingredients—nicotinamide, wheat germ extract, oat β-glucan, and camellia chrysantha extract—can work synergistically to repair the barrier, soothe, and optimize sebum production.

[0094] Based on the data from Application Examples 1-7, it can be seen that when the weight ratio of nicotinamide, wheat germ extract, oat β-glucan, and camellia flower extract is (1-2):(0.6-1):(0.8-1):(0.5-1), the composition has better barrier repair, soothing, and sebum optimization effects.

[0095] like Figure 2 As shown, the facial redness of volunteers who used the serum of Application Example 1 for 28 days was significantly improved, while the improvement in facial redness of volunteers who used the serum of Comparative Application Example 5 for 28 days was worse than that of Application Example 1. This indicates that the serum made with the barrier repair composition of the present invention has good effects in repairing the barrier, soothing and optimizing sebum.

[0096] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A barrier repair composition for activating cellular energy, characterized in that, It is composed of the following components: nicotinamide, wheat germ extract, oat β-glucan and camellia oleifera flower extract, wherein the weight ratio of nicotinamide, wheat germ extract, oat β-glucan and camellia oleifera flower extract is (0.1-5):(0.1-3):(0.1-3):(0.1-5).

2. The barrier repair composition for activating cellular energy as described in claim 1, characterized in that, The weight ratio of nicotinamide, wheat germ extract, oat β-glucan and Camellia chrysantha extract is (1-3):(0.1-1):(0.5-2):(0.5-2).

3. The barrier repair composition for activating cellular energy as described in claim 1, characterized in that, The weight ratio of nicotinamide, wheat germ extract, oat β-glucan and Camellia chrysantha extract is (1-2):(0.6-1):(0.8-1):(0.5-1).

4. The use of the barrier repair composition for activating cellular energy according to any one of claims 1-3 in the preparation of skin care products, characterized in that, The skincare product is any one of toner, lotion, cream, mask, serum, or spray, and the amount of the composition added is 0.5%-5% of the total weight of the skincare product.

5. An essence, characterized in that, The ingredients comprise the following ingredients by weight percentage: 0.5%-5% of the composition according to any one of claims 1-3, 0.05%-0.3% of thickener, 0.5%-10% of humectant, 0.5%-5% of preservative, 0.01%-0.3% of pH adjuster, and 0.01%-1% of fragrance, with the balance being deionized water.

6. The essence as described in claim 5, characterized in that, The raw material is selected from at least one of (a)-(d): (a) The thickener comprises at least one of xanthan gum, carbomer, hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, ammonium acryloyl dimethyl taurate / VP copolymer, sclerotium gum, and cetyl alcohol; (b) The moisturizer includes at least one of allantoin, sodium polyacrylate, hydrogenated lecithin, betaine, β-glucan, trehalose, caprylyl glycol, dipropylene glycol, hydrolyzed sodium hyaluronate, 1,2-butanediol, glycerin, budding stalk polysaccharide, and ceramide. (c) The pH adjuster includes at least one of arginine, tromethamine, and disodium EDTA; (d) The preservative includes at least one of 1,2-propanediol, 1,2-hexanediol and p-hydroxyacetophenone.

7. The method for preparing the essence according to claim 5, characterized in that, Includes the following steps: S1. Mix the humectant, thickener and part of the deionized water, homogenize at 75-85℃, then add the preservative and stir evenly to obtain the mixture. S2. When the temperature drops to 35-45℃, add each component of the composition, fragrance and remaining deionized water to the mixture obtained in step S1, stir evenly, and finally add pH adjuster to adjust pH to obtain the essence.

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