Traditional Chinese medicine composition for treating hyperactivity autism and preparation method thereof

Abstract

The invention belongs to the technical field of medicines, and particularly provides a traditional Chinese medicine composition for treating hyperactivity autism and a preparation method thereof. According to the invention, turtle shell, radix rehmanniae, pulp of dogwood fruit, Chinese yam, astragalus membranaceus, poria cocos, cortex moutan, rhizoma alismatis, golden cypress, rhizoma anemarrhenae, liquorice, fructus amomi, cinnamon and folium mori are adopted as raw materials and are subjected to proper weight proportioning; wherein the turtle shell, the radix rehmanniae and the radix astragali are used as monarch drugs, the Chinese yam, the pulp of dogwood fruit, the rhizoma anemarrhenae and the cortex phellodendri are used as ministerial drugs, the poria cocos, the cortex moutan, the rhizoma alismatis, the fructus amomi, the folium mori and the cortex cinnamomi are used as adjuvant drugs, and the liquorice is used as a conductant drug, so that the effect of treating the hyperactivity autism can be achieved under the combined action of the medicinal components. The pharmaceutical composition disclosed by the invention is good in treatment effect and high in safety.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating hyperactive autism and a preparation method thereof. Background Art

[0002] At present, autism, also known as autism spectrum disorder (ASD), is a representative disease of neurodevelopmental disorder. The symptoms of autism begin to appear before the age of 3 in children, mainly manifested as social disorders and repetitive stereotyped behaviors. Autism is generally considered to be the result of the combined action of genetic and environmental factors. Currently, the incidence of autism in children and adolescents is 1 / 59. There is no effective drug reported yet, and early detection and early intervention are effective means for preventing and treating this disease.

[0003] Attention deficit hyperactivity disorder (ADHD), also known as hyperactivity disorder, is a common neurodevelopmental disorder in children, mainly manifested as distractibility, short attention span, hyperactivity, impulsive behavior and learning difficulties that are disproportionate to age. It usually begins in childhood, and some symptoms may persist into adulthood.

[0004] Currently, the methods for treating autism and ADHD are mostly rehabilitation treatment methods. This method has limited treatment effect on autistic children, and the cost of this method is huge, which will cause a certain economic burden to the family. Therefore, there is an urgent need in the prior art for a drug with low cost and effective in alleviating autism-related symptoms.

[0005] However, there is currently no specific drug for treating ASD and ADHD clinically. Western medicine mainly focuses on human intervention and applied behavior analysis training, with drugs as a supplement. In drug treatment, atypical antipsychotics are usually used, but Western medicine has certain side effects, and long-term medication may cause adverse reactions such as weight changes and extrapyramidal reactions. Summary of the Invention

[0006] In order to solve the above problems existing in the prior art, the present invention provides a traditional Chinese medicine composition for treating hyperactive autism with good treatment effect and high safety and a preparation method thereof.

[0007] The technical solution adopted by the present invention is as follows: The present invention provides a traditional Chinese medicine composition for treating hyperactive autism in a first aspect. The raw material components include: 5 - 15 parts by weight of turtle shell, 5 - 15 parts by weight of rehmannia root, 5 - 15 parts by weight of dogwood fruit, 5 - 15 parts by weight of Chinese yam, 5 - 15 parts by weight of astragalus root, 5 - 15 parts by weight of poria cocos, 5 - 15 parts by weight of moutan bark, 5 - 15 parts by weight of alisma rhizome, 2 - 8 parts by weight of phellodendron bark, 2 - 8 parts by weight of anemarrhena rhizome, 2 - 8 parts by weight of liquorice root, 2 - 8 parts by weight of amomum fruit, 2 - 8 parts by weight of cassia bark Further preferably, the raw material components of the traditional Chinese medicine composition for treating hyperactive autism include: 8 - 12 parts by weight of turtle shell, 8 - 12 parts by weight of rehmannia root, 8 - 12 parts by weight of dogwood fruit, 8 - 12 parts by weight of Chinese yam, 8 - 12 parts by weight of astragalus root, 8 - 12 parts by weight of poria cocos, 8 - 12 parts by weight of moutan bark, 8 - 12 parts by weight of alisma rhizome, 3 - 7 parts by weight of phellodendron bark, 3 - 7 parts by weight of anemarrhena rhizome, 3 - 7 parts by weight of liquorice root, 3 - 7 parts by weight of amomum fruit, 3 - 7 parts by weight of cassia bark.

[0008] Further preferably, the raw material components of the traditional Chinese medicine composition for treating hyperactive autism include: 10 parts by weight of turtle shell, 10 parts by weight of rehmannia root, 10 parts by weight of dogwood fruit, 10 parts by weight of Chinese yam, 10 parts by weight of astragalus root, 10 parts by weight of poria cocos, 10 parts by weight of moutan bark, 10 parts by weight of alisma rhizome, 5 parts by weight of phellodendron bark, 5 parts by weight of anemarrhena rhizome, 5 parts by weight of liquorice root, 5 parts by weight of amomum fruit, 5 parts by weight of cassia bark.

[0009] Further preferably, the raw material components of the traditional Chinese medicine composition for treating hyperactive autism further include 2 - 8 parts by weight of mulberry leaves.

[0010] The dosage form of the traditional Chinese medicine composition is a patch.

[0011] The second aspect of the present invention provides a preparation method of the traditional Chinese medicine composition for treating hyperactive autism, including the following steps: (1) Take turtle shell, rehmannia root, dogwood fruit, Chinese yam, astragalus root, and poria cocos according to parts by weight, and after pulverization, obtain each traditional Chinese medicine powder; (2) Mix each traditional Chinese medicine powder evenly, and then add water for water extraction treatment to obtain a water extract; (3) After filtering the water extract in step (2), successively concentrate, dry, and superfine pulverize it to obtain a superfine powder; (4) Take the remaining raw material components, after separately superfine pulverizing them, successively add them to the superfine powder obtained in step (3), and mix evenly to obtain the traditional Chinese medicine composition for treating hyperactive autism.

[0012] In step (4), after mixing each superfine powder evenly, add conventional excipients to make a patch.

[0013] In step (1), the particle size of each traditional Chinese medicine powder is 80 - 100 mesh.

[0014] In step (2), the mass ratio of the traditional Chinese medicine mixed powder to the added water is 1:2 - 1:5; the time for water extraction treatment is 3 - 6 h.

[0015] In step (3), the concentration is carried out by reduced-pressure concentration to obtain a thick paste with a relative density of 1.31 - 1.33.

[0016] In steps (3) and (4), the particle size of the ultrafine powder obtained after ultrafine grinding is 600 - 1000 mesh.

[0017] Use of the described traditional Chinese medicine composition in the preparation of a medicament for treating hyperactive autism.

[0018] Soft-shelled turtle shell, salty in taste and slightly cold in nature. It has the efficacy of nourishing yin, suppressing yang and calming endogenous wind, and can be used for symptoms such as yin deficiency with internal heat, stirring up of endogenous wind due to yin deficiency, hyperactivity of yang due to yin deficiency, dizziness and vertigo, infantile convulsion, etc. caused by deficiency of the liver and kidney yin.

[0019] Rehmannia root, sweet and bitter in taste and slightly cold in nature. It nourishes yin and clears heat, cools blood and nourishes blood. It is mainly used for febrile disease with vexation and thirst, internal heat and polydipsia, steaming bone fever, maculae caused by warm diseases, hematemesis, metrorrhagia, hematuria, hematochezia caused by blood heat, sallow complexion due to blood deficiency, dizziness and palpitation, amenorrhea due to blood deficiency.

[0020] Asiatic cornel fruit, sour and astringent in taste and slightly warm in nature. It tonifies the liver and kidney, astringes essence and arrests discharge. It is used for dizziness and tinnitus, soreness and weakness of the waist and knees, impotence and spermatorrhea, enuresis and frequent urination, metrorrhagia and leukorrhagia, profuse sweating and collapse. Internal heat and polydipsia.

[0021] Common yam rhizome, sweet in taste and neutral in nature. It invigorates the spleen and stomach, promotes fluid production and benefits the lungs, tonifies the kidney and astringes essence. It is used for less appetite due to spleen deficiency, chronic diarrhea, cough due to lung deficiency, spermatorrhea due to kidney deficiency, leukorrhea, frequent urination, deficiency heat and polydipsia. Stir-fried common yam rhizome with bran invigorates the spleen and stomach. It is used for less appetite due to spleen deficiency, loose stools and excessive leukorrhea.

[0022] Astragalus membranaceus, sweet in taste and slightly warm in nature. It has the efficacy of invigorating the spleen and replenishing qi, lifting yang and raising prolapse, benefiting qi and strengthening the exterior, promoting diuresis, expelling toxin and promoting granulation. It is mainly used for syndrome of spleen qi deficiency, syndrome of lung qi deficiency, syndrome of spontaneous sweating due to qi deficiency, qi and blood deficiency, sores and ulcers that are difficult to ulcerate and heal, or those that are difficult to heal after long-term ulceration, etc.

[0023] Poria cocos, sweet and light in taste and neutral in nature. It promotes diuresis and percolates dampness, invigorates the spleen, calms the mind. It is used for oliguria with edema, dizziness and palpitation due to retention of phlegm-fluid, less appetite due to spleen deficiency, loose stools and diarrhea, restlessness of the mind, palpitation and insomnia.

[0024] Moutan bark, bitter, pungent in taste and slightly cold in nature. It has the functions of clearing heat and cooling blood, promoting blood circulation and removing stasis, and is used for treating heat invading nutrient-blood, epidemic febrile disease with maculae, hematemesis and epistaxis, feverish sensation in the evening and early morning coolness, anhidrotic fever, amenorrhea and dysmenorrhea, traumatic injury and pain, carbuncles and sores.

[0025] Alisma orientale, sweet and light in taste and cold in nature. It promotes diuresis and percolates dampness, clears heat, reduces turbidity and lowers lipid. It is used for dysuria, edema and fullness, diarrhea with oliguria, dizziness and palpitation due to retention of phlegm-fluid, stranguria with pain due to heat, hyperlipidemia.

[0026] Phellodendron amurense Rupr., bitter in taste and cold in nature, has the effects of clearing away heat and drying dampness, purging fire and removing steaming, detoxifying and treating sores. It is used for damp-heat diarrhea, jaundice with reddish urine, leukorrheal itching in the lower genital tract, painful and difficult urination due to heat strangury, beriberi with flaccidity and weakness, bone-steaming fever due to consumptive disease, night sweats, spermatorrhea, sores and boils, eczema and damp sores. Salt-processed Phellodendron amurense Rupr. nourishes yin and purges fire, and is used for yin deficiency with hyperactive fire, night sweats and bone-steaming fever.

[0027] Anemarrhena asphodeloides Bge., bitter in taste and cold in nature, clears away heat and purges fire, nourishes yin and moistens dryness. It is used for febrile disease with vexatious thirst, dry cough due to lung heat, bone-steaming and tidal fever, internal heat and polydipsia, and constipation due to intestinal dryness.

[0028] Glycyrrhiza uralensis Fisch., sweet in taste and neutral in nature, invigorates the spleen and replenishes qi, clears heat and detoxifies, reduces phlegm and relieves cough, alleviates spasm and pain, and harmonizes various medicinal herbs. It is used for weakness of the spleen and stomach, lassitude and fatigue, palpitation and shortness of breath, profuse phlegm and cough, spasm and pain in the abdomen and extremities, carbuncles and sores, and relieving the toxicity and potency of medicinal herbs.

[0029] Amomum villosum Lour., pungent in taste and warm in nature, has the effects of promoting digestion by resolving dampness, warming the spleen and stopping diarrhea, regulating qi and preventing miscarriage. It is used for dampness obstructing the middle energizer, fullness and lack of appetite in the epigastric region, deficiency-cold of the spleen and stomach, vomiting and diarrhea, morning sickness during pregnancy, and restlessness of the fetus.

[0030] Cinnamomum cassia Presl., pungent and sweet in taste, extremely hot in nature, has the effects of tonifying fire and assisting yang, leading back floating yang, dispersing cold and relieving pain, warming and dredging the channels. It is used for impotence and coldness in the uterus, cold pain in the waist and knees, dyspnea due to kidney deficiency, floating yang due to deficiency, dizziness and redness of the eyes, cold pain in the heart and abdomen, deficiency-cold vomiting and diarrhea, cold hernia pain, dysmenorrhea and amenorrhea.

[0031] Mulberry leaf, sweet and bitter in taste, cold in nature, disperses wind-heat, moistens the lung and relieves dryness, clears the liver and improves eyesight. It is used for wind-heat cold, dry cough due to lung heat, dizziness and headache, and dimness and turbidity of vision.

[0032] The present invention has the following beneficial effects: The present invention provides a traditional Chinese medicine composition for treating hyperactive autism, which uses turtle shell, rehmannia root, dogwood fruit, Chinese yam, astragalus root, poria cocos, moutan bark, alisma rhizome, phellodendron bark, anemarrhena rhizome, liquorice root, amomum fruit, cinnamon bark, mulberry leaf, etc. as raw materials and performs appropriate weight ratios; among them, turtle shell, rehmannia root, and astragalus root are used as the monarch drugs. Turtle shell nourishes yin and suppresses yang, rehmannia root clears heat and cools blood, nourishes yin and promotes fluid production, and astragalus root supplements qi and raises yang. The combination of turtle shell, rehmannia root, and astragalus root jointly plays the role of supplementing qi, nourishing yin, and suppressing yang, which is the main attack direction of the whole formula and lays the foundation for tonifying deficiency and suppressing yang; Chinese yam, dogwood fruit, anemarrhena rhizome, and phellodendron bark are used as ministerial drugs. Chinese yam invigorates the spleen and lungs, tonifies the kidney and astringes essence; dogwood fruit tonifies the liver and kidneys, synergistically enhancing the tonifying effect of astragalus root and rehmannia root. Anemarrhena rhizome clears heat and purges fire, nourishes yin and moistens dryness, and phellodendron bark clears heat and dries dampness; among them, Chinese yam and dogwood fruit tonify the liver, spleen, and kidneys, enhancing the tonifying power of the monarch drug; anemarrhena rhizome and phellodendron bark clear heat and purge fire, preventing excessive nourishment from generating internal heat, playing the role of both tonifying and purging; poria cocos promotes diuresis and percolates dampness, strengthens the spleen and calms the mind; moutan bark clears heat and cools blood, promotes blood circulation and removes stasis; alisma rhizome promotes diuresis and percolates dampness, clears heat and purges fire; amomum fruit resolves dampness and promotes appetite, warms the spleen and stops diarrhea; mulberry leaf clears the lung and moistens dryness, and cinnamon bark warms the meridians and promotes blood circulation, helps yang transform qi; poria cocos, alisma rhizome, and amomum fruit strengthen the spleen and promote diuresis, enhancing the transportation and transformation function of the spleen and stomach; moutan bark clears heat and cools blood, promotes blood circulation and removes stasis, preventing blood stasis from blocking the interior; mulberry leaf clears the lung and moistens dryness, regulating the qi of the lung; cinnamon bark warms the meridians and aids yang, regulating yin and yang, and overall playing the role of regulating the zang-fu organs and balancing yin and yang. Liquorice root harmonizes all the drugs, supplements qi of the spleen, runs through the whole formula, enables each drug to play a synergistic role, and at the same time supplements qi of the spleen, enhancing the transportation and transformation function of the spleen and stomach, and is the finishing drug of the whole formula. Under the synergistic effect of the above various drug components, it can achieve the effect of treating hyperactive autism. The drug composition of the present invention has good treatment effects and high safety. Detailed implementation manners

[0033] To make the objectives, technical solutions, and advantages of the present invention clearer, the technical solutions of the present invention will be described in detail below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other implementation manners obtained by those of ordinary skill in the art without creative efforts shall fall within the scope protected by the present invention.

[0034] Unless otherwise specified, the reagents involved in the specific implementation manners of the present invention are all commercially available products and can be obtained through commercial channels.

[0035] In the following examples, 1 part by weight represents 1 g.

[0036] Example 1 This example provides a traditional Chinese medicine composition for treating hyperactive autism, and the raw material components include: 5 parts by weight of turtle shell, 15 parts by weight of rehmannia root, 5 parts by weight of dogwood fruit, 15 parts by weight of Chinese yam, 5 parts by weight of astragalus root, 15 parts by weight of poria cocos, 5 parts by weight of moutan bark, 15 parts by weight of alisma rhizome, 2 parts by weight of phellodendron bark, 8 parts by weight of anemarrhena rhizome, 2 parts by weight of liquorice root, 8 parts by weight of amomum fruit, 2 parts by weight of cinnamon bark, 8 parts by weight of mulberry leaf.

[0037] The preparation method of the traditional Chinese medicine composition for treating hyperactive autism comprises the following steps: (1) Take turtle shell, rehmannia root, dogwood fruit, Chinese yam, astragalus root, and poria cocos according to parts by weight. After pulverization, each traditional Chinese medicine powder with a particle size of 80 meshes is obtained; (2) Mix each traditional Chinese medicine powder evenly, and then add 2 times the mass of water for water extraction for 6 hours to obtain a water extract; (3) After filtering the water extract described in step (2), concentrate it to a thick paste with a relative density of 1.31 to obtain a concentrate; after drying the concentrate, perform ultrafine pulverization to obtain an ultrafine powder with a particle size of 600 meshes; (4) Take the remaining raw materials, after separately performing ultrafine pulverization to a particle size of 600 meshes, add them to the ultrafine powder obtained in step (3), and mix evenly to obtain the traditional Chinese medicine composition for treating hyperactive autism; Add vaseline to the obtained traditional Chinese medicine composition. The mass ratio of the traditional Chinese medicine mixed powder to vaseline is 1:2. Mix evenly to obtain an ointment; further apply the ointment to the leak-proof ring of the medical patch, and cover it with an anti-adhesive layer after cooling to obtain a patch.

[0038] Example 2 This example provides a traditional Chinese medicine composition for treating hyperactive autism, and the raw material components include: 15 parts by weight of turtle shell, 5 parts by weight of rehmannia root, 15 parts by weight of dogwood fruit, 5 parts by weight of Chinese yam, 15 parts by weight of astragalus root, 5 parts by weight of poria cocos, 15 parts by weight of moutan bark, 5 parts by weight of alisma rhizome, 8 parts by weight of phellodendron bark, 2 parts by weight of anemarrhena rhizome, 8 parts by weight of liquorice root, 2 parts by weight of amomum fruit, 8 parts by weight of cinnamon bark, 2 parts by weight of mulberry leaf.

[0039] The preparation method of the traditional Chinese medicine composition for treating hyperactive autism comprises the following steps: (1) Take turtle shell, rehmannia root, dogwood fruit, Chinese yam, astragalus root, and poria cocos according to parts by weight. After pulverization, each traditional Chinese medicine powder with a particle size of 100 meshes is obtained; (2) Mix each traditional Chinese medicine powder evenly, and then add 5 times the mass of water for water extraction for 3 hours to obtain a water extract; (3) After filtering the water extract described in step (2), concentrate it to a thick paste with a relative density of 1.33 to obtain a concentrate; after drying the concentrate, perform ultrafine pulverization to obtain an ultrafine powder with a particle size of 1000 meshes; (4) Take the remaining raw materials, separately ultrafinely pulverize them to a particle size of 1000 mesh, and then add them to the ultrafine powder obtained in step (3). Mix thoroughly to obtain the traditional Chinese medicine composition for treating hyperactive autism; Add vaseline to the obtained traditional Chinese medicine composition. The mass ratio of the traditional Chinese medicine mixed powder to vaseline is 1:2. Mix thoroughly to obtain an ointment; further apply the ointment to the leakage-proof ring of the medical patch, cover it with an anti-adhesive layer after cooling to obtain the patch.

[0040] Example 3 This example provides a traditional Chinese medicine composition for treating hyperactive autism, and the raw material components include: 8 parts by weight of turtle shell, 12 parts by weight of rehmannia root, 8 parts by weight of cornel, 12 parts by weight of Chinese yam, 8 parts by weight of astragalus membranaceus, 12 parts by weight of poria cocos, 8 parts by weight of moutan bark, 12 parts by weight of alisma orientale, 3 parts by weight of phellodendron amurense, 7 parts by weight of anemarrhena asphodeloides, 3 parts by weight of licorice root, 7 parts by weight of amomum villosum, 3 parts by weight of cinnamon, 7 parts by weight of mulberry leaf.

[0041] The preparation method of the traditional Chinese medicine composition for treating hyperactive autism includes the following steps: (1) Take turtle shell, rehmannia root, cornel, Chinese yam, astragalus membranaceus, and poria cocos by weight. After pulverization, obtain each traditional Chinese medicine powder with a particle size of 900 mesh; (2) Mix each traditional Chinese medicine powder thoroughly, then add 4 times the mass of water for water extraction for 4 hours to obtain a water extract; (3) After filtering the water extract in step (2), concentrate it to a thick paste with a relative density of 1.32 to obtain a concentrate; dry the concentrate and then ultrafinely pulverize it to obtain an ultrafine powder with a particle size of 800 mesh; (4) Take the remaining raw materials, separately ultrafinely pulverize them to a particle size of 800 mesh, and then add them to the ultrafine powder obtained in step (3). Mix thoroughly to obtain the traditional Chinese medicine composition for treating hyperactive autism; Add vaseline to the obtained traditional Chinese medicine composition. The mass ratio of the traditional Chinese medicine mixed powder to vaseline is 1:2. Mix thoroughly to obtain an ointment; further apply the ointment to the leakage-proof ring of the medical patch, cover it with an anti-adhesive layer after cooling to obtain the patch.

[0042] Example 4 This example provides a traditional Chinese medicine composition for treating hyperactive autism, and the raw material components include: 12 parts by weight of turtle shell, 8 parts by weight of rehmannia root, 12 parts by weight of cornel, 8 parts by weight of Chinese yam, 12 parts by weight of astragalus membranaceus, 8 parts by weight of poria cocos, 12 parts by weight of moutan bark, 8 parts by weight of alisma orientale, 7 parts by weight of phellodendron amurense, 3 parts by weight of anemarrhena asphodeloides, 7 parts by weight of licorice root, 3 parts by weight of amomum villosum, 7 parts by weight of cinnamon, 3 parts by weight of mulberry leaf.

[0043] The preparation method of the traditional Chinese medicine composition for treating hyperactive autism comprises the following steps: (1) Weigh turtle shell, rehmannia root, dogwood fruit, Chinese yam, astragalus root, and poria cocos according to parts by weight. After pulverization, each traditional Chinese medicine powder with a particle size of 90 mesh is obtained; (2) Mix each traditional Chinese medicine powder thoroughly, and then add 4 times the mass of water for water extraction for 5 hours to obtain a water extract; (3) After filtering the water extract obtained in step (2), concentrate it to a thick paste with a relative density of 1.32 to obtain a concentrate; after drying the concentrate, perform ultrafine pulverization to obtain an ultrafine powder with a particle size of 900 mesh; (4) Take the remaining raw materials, after separately performing ultrafine pulverization to a particle size of 900 mesh, add them to the ultrafine powder obtained in step (3), and mix thoroughly to obtain the traditional Chinese medicine composition for treating hyperactive autism; Add vaseline to the obtained traditional Chinese medicine composition. The mass ratio of the traditional Chinese medicine mixed powder to vaseline is 1:2. Mix thoroughly to obtain an ointment; further apply the ointment to the leakage-proof ring of the medical patch, and cover it with an anti-adhesive layer after cooling to obtain a patch.

[0044] Example 5 This example provides a traditional Chinese medicine composition for treating hyperactive autism, and the raw material components include: 10 parts by weight of turtle shell, 10 parts by weight of rehmannia root, 10 parts by weight of dogwood fruit, 10 parts by weight of Chinese yam, 10 parts by weight of astragalus root, 10 parts by weight of poria cocos, 10 parts by weight of moutan bark, 10 parts by weight of alisma rhizome, 5 parts by weight of phellodendron bark, 5 parts by weight of anemarrhena rhizome, 5 parts by weight of licorice root, 5 parts by weight of amomum fruit, 5 parts by weight of cinnamon bark, 5 parts by weight of mulberry leaf.

[0045] The preparation method of the traditional Chinese medicine composition for treating hyperactive autism comprises the following steps: (1) Weigh turtle shell, rehmannia root, dogwood fruit, Chinese yam, astragalus root, and poria cocos according to parts by weight. After pulverization, each traditional Chinese medicine powder with a particle size of 90 mesh is obtained; (2) Mix each traditional Chinese medicine powder thoroughly, and then add 4 times the mass of water for water extraction for 4 hours to obtain a water extract; (3) After filtering the water extract obtained in step (2), concentrate it to a thick paste with a relative density of 1.32 to obtain a concentrate; after drying the concentrate, perform ultrafine pulverization to obtain an ultrafine powder with a particle size of 800 mesh; (4) Take the remaining raw materials, after separately performing ultrafine pulverization to a particle size of 800 mesh, add them to the ultrafine powder obtained in step (3), and mix thoroughly to obtain the traditional Chinese medicine composition for treating hyperactive autism; Vaseline is added to the obtained traditional Chinese medicine composition, with the mass ratio of the traditional Chinese medicine mixed powder to vaseline being 1:2, and the mixture is fully and evenly mixed to obtain an ointment; the ointment is further applied to the leak-proof circle of the medicine patch, and after cooling, an anti-sticking layer is applied to obtain a patch.

[0046] In summary, the pharmaceutical composition of the present invention has good therapeutic effect and high safety; the pharmaceutical composition of the present invention is made into a patch, and the patch is used in combination with corresponding acupoints for external application treatment, which can ultimately achieve effective and better therapeutic effect.

Claims

1. A Chinese medicine composition for treating ADHD, characterized in that: The raw material components include: 8-12 parts by weight of turtle shell, 8-12 parts by weight of raw rehmannia, 8-12 parts by weight of cornus fruit, 8-12 parts by weight of yam, 8-12 parts by weight of astragalus, 8-12 parts by weight of poria, 8-12 parts by weight of moutan bark, 8-12 parts by weight of oriental rhizome, 3-7 parts by weight of phellodendron, 3-7 parts by weight of anemarrhena, 3-7 parts by weight of liquorice, 3-7 parts by weight of amomum, and 3-7 parts by weight of cinnamon.

2. The Chinese medicine composition for treating ADHD according to claim 2, characterized in that: The raw material components include: 10 parts by weight of turtle shell, 10 parts by weight of raw rehmannia, 10 parts by weight of cornus fruit, 10 parts by weight of yam, 10 parts by weight of astragalus, 10 parts by weight of poria, 10 parts by weight of moutan bark, 10 parts by weight of oriental rhizome, 5 parts by weight of phellodendron, 5 parts by weight of anemarrhena, 5 parts by weight of liquorice, 5 parts by weight of amomum, and 5 parts by weight of cinnamon.

3. The Chinese medicine composition for treating ADHD according to claim 1, characterized in that: The raw material components also include: 2-8 parts by weight of mulberry leaves.

4. The Chinese medicine composition for treating ADHD according to claim 1, characterized in that: The dosage form of the Chinese medicine composition is a patch.

5. The method for preparing the Chinese medicine composition for treating ADHD according to any one of claims 1 to 4, characterized in that: The steps include: (1) Taking turtle shell, raw rehmannia, cornus fruit, yam, astragalus, and poria according to weight, and crushing them to obtain respective Chinese medicine powders; (2) fully mixing the Chinese medicinal powders, then adding water for water extraction to obtain a water extract; (3) filtering the aqueous extract of step (2), and then concentrating, drying and ultrafine grinding in sequence to obtain ultrafine powder; (4) The remaining raw material components are taken, and after being ultrafinely ground respectively, they are added to the ultrafine powder obtained in step (3) in sequence, and mixed thoroughly to obtain the Chinese medicine composition for treating ADHD.

6. The method for preparing the Chinese medicine composition for treating ADHD according to claim 5, characterized in that: In step (4), the ultrafine powders are fully mixed and then conventional auxiliary materials are added to prepare a patch.

7. The method for preparing the Chinese medicine composition for treating ADHD according to claim 6 or 7, characterized in that: In step (1), the particle size of each Chinese medicine powder is 80-100 mesh; In step (2), the mass ratio of the Chinese medicine mixed powder to the added water is 1:2-1:5; and the water extraction treatment time is 3-6 hours.

8. The method for preparing the Chinese medicine composition for treating ADHD according to claim 6 or 7, characterized in that: In step (3), the concentration is concentrated under reduced pressure to a thick paste with a relative density of 1.31-1.33; In step (3) and step (4), the particle size of the ultrafine powder obtained after ultrafine grinding is 600-1000 mesh.

9. Use of the Chinese medicine composition according to any one of claims 1 to 5 or the Chinese medicine composition prepared by the method according to any one of claims 6 to 9 in the preparation of a medicament for treating ADHD.