Traditional Chinese medicine composition for treating cancer pain

Abstract

The invention discloses a traditional Chinese medicine composition for treating cancer pain. The traditional Chinese medicine composition is prepared from, by weight, 30-70 parts of rhizoma corydalis, 30-70 parts of rhizoma corydalis decumbentis, 7-3 parts of radix curcumae, 7-3 parts of radix angelicae sinensis, 7-3 parts of radix salviae miltiorrhizae, 10-6 parts of frankincense, 10-6 parts of myrrh, 7-3 parts of radix bupleuri, 7-3 parts of fructus aurantii immaturus, 6-10 parts of radix paeoniae alba and 3-7 parts of radix glycyrrhizae. And 7-3 parts of rhizoma cyperi. The traditional Chinese medicine composition disclosed by the invention is researched and developed on the basis of diagnosis and treatment of cancer pain pathogenesis in traditional Chinese medicine, and has a good effect on treatment of cancer pain, particularly moderate pain and severe pain in late stage of cancer.

Description

[0001] The present invention relates to traditional Chinese medicine for treating cancer pain, and particularly to a traditional Chinese medicine composition for treating cancer pain. Background Art

[0002] Traditional Chinese medicine's understanding of cancer is closely related to traditional medical theories, and corresponding relationships can be found in diseases such as accumulations, masses, carcinomas, tumors, and dysphagia. Pain has become one of the common symptoms of cancer. Severe pain in some advanced cancer patients has brought huge mental and psychological traumas to patients and their families. How to effectively relieve severe cancer pain while reducing treatment side effects is a major issue of concern to cancer pain patients, their families, and relevant parties in society. In treating severe pain in advanced cancer patients, Western medicine often uses large doses of strong opioid drugs. Since there is no standard upper limit dose for opioid drugs, for example, the dose of morphine can be gradually increased until it is effective. Therefore, for severe pain in advanced cancer patients, using a large dose of morphine for pain relief brings great side effects to patients and is also addictive. There are countless traditional Chinese medicine formulas for treating cancer, but often insufficient attention is paid to pain as one of the main symptoms in advanced cancer patients. Therefore, traditional Chinese medicine formulas for the comprehensive treatment of cancer and their applications are often lacking. In view of the above situation, it is necessary to continuously improve and innovate new traditional Chinese medicine formulas for treating cancer pain, better play the advantages of traditional Chinese medicine in treating cancer pain, such as small side effects and non-addictiveness, and good pain treatment effects, effectively relieve patients' pain, and improve the quality of life. Summary of the Invention

[0003] In order to overcome the deficiencies of the prior art, a traditional Chinese medicine composition for treating cancer pain, especially moderate and severe pain, is proposed to solve the problems raised in the above background art.

[0004] In order to achieve the above object, the present invention is realized through the following technical solutions: The pathogenesis of cancer pain differentiated by traditional Chinese medicine is mainly divided into three categories: 1. Qi stagnation type cancer pain; 2. Blood stasis type cancer pain; 3. Qi stagnation and blood stasis type cancer pain. Therefore, it is necessary to start from two aspects: regulating qi and relieving depression, promoting qi circulation to relieve pain, activating blood circulation to remove stasis, and dredging collaterals to relieve pain. It is necessary to carefully select the compatibility of medicines and the dosage to effectively treat cancer pain without harming the patient's body and constitution.

[0005] A traditional Chinese medicine composition for treating cancer pain comprises the following raw materials by weight: 30 - 70 parts of Corydalis Rhizoma, 30 - 70 parts of Uncaria Rhynchophylla, 7 - 3 parts of Curcuma Radix, 7 - 3 parts of Angelica Sinensis Radix, 7 - 3 parts of Salvia Miltiorrhiza Radix, 10 - 6 parts of Olibanum, 10 - 6 parts of Myrrha, 7 - 3 parts of Bupleuri Radix, 7 - 3 parts of Aurantii Fructus Immaturus, 6 - 10 parts of Paeoniae Radix Alba, 3 - 7 parts of Glycyrrhizae Radix, 7 - 3 parts of Cyperi Rhizoma.

[0006] As a further technical solution of the present invention, it comprises the following raw materials by weight: 40 - 60 parts of Corydalis yanhusuo, 40 - 60 parts of Uncaria rhynchophylla, 6 - 4 parts of Curcuma aromatica Salisb., 6 - 4 parts of Angelica sinensis (Oliv.) Diels, 6 - 4 parts of Salvia miltiorrhiza Bunge, 9 - 7 parts of Olibanum, 9 - 7 parts of Myrrha, 6 - 4 parts of Bupleurum chinense DC., 6 - 4 parts of Aurantii Fructus Immaturus, 7 - 9 parts of Paeonia lactiflora Pall., 4 - 6 parts of Glycyrrhiza uralensis Fisch., 6 - 4 parts of Cyperus rotundus L.

[0007] As a further technical solution of the present invention, it includes the following raw medicinal materials in parts by weight: 50 parts of Corydalis yanhusuo, 50 parts of Uncaria rhynchophylla, 5 parts of Curcuma aromatica Salisb., 5 parts of Angelica sinensis (Oliv.) Diels, 5 parts of Salvia miltiorrhiza Bunge, 8 parts of Olibanum, 8 parts of Myrrha, 5 parts of Bupleurum chinense DC., 5 parts of Aurantii Fructus Immaturus, 8 parts of Paeonia lactiflora Pall., 5 parts of Glycyrrhiza uralensis Fisch., 5 parts of Cyperus rotundus L.

[0008] The technical solution of the present invention is to provide a traditional Chinese medicine composition for treating cancer pain. Add the excipients required for preparation into the traditional Chinese medicine composition, and it can be made according to the conventional methods for preparing preparations.

[0009] Furthermore, the above traditional Chinese medicine preparation is a decoction, powder, pill, tablet, granule, capsule or oral liquid.

[0010] The beneficial effects of the present invention: The pharmacological effects and compatibility of each raw medicinal material in the present invention are as follows: Corydalis yanhusuo, pungent and bitter in taste, warm in nature; attributing to the liver and spleen meridians. Main effects: promoting blood circulation to remove stasis, regulating qi to relieve pain.

[0011] Uncaria rhynchophylla, bitter and pungent in taste, cool in nature; attributing to the liver and kidney meridians. Main effects: dispelling wind and dampness, relaxing tendons and activating blood circulation, dredging collaterals to relieve pain.

[0012] Curcuma aromatica Salisb., pungent and bitter in taste, cold in nature; attributing to the heart, liver and lung meridians. Main effects: regulating qi to relieve depression, promoting blood circulation to relieve pain, clearing heart and cooling blood, promoting bile secretion and removing jaundice.

[0013] Angelica sinensis (Oliv.) Diels, sweet and pungent in taste, warm in nature; attributing to the liver, heart and spleen meridians. Main effects: enriching blood and promoting blood circulation, regulating menstruation and relieving pain, moistening intestines and relaxing bowels.

[0014] Salvia miltiorrhiza Bunge, bitter in taste, slightly cold in nature; attributing to the heart and liver meridians. Main effects: promoting blood circulation to remove stasis, regulating menstruation and relieving pain, nourishing blood and calming the mind.

[0015] Olibanum, pungent and bitter in taste, slightly warm in nature; attributing to the heart, liver and spleen meridians. Main effects: promoting blood circulation and regulating qi, dredging meridians to relieve pain, detumescence and promoting granulation.

[0016] Myrrha, bitter in taste, neutral in nature; attributing to the heart, liver and spleen meridians. Main effects: promoting blood circulation to relieve pain, detumescence and promoting granulation.

[0017] Bupleurum chinense DC., bitter in taste, slightly cold in nature; attributing to the liver and gallbladder meridians. Main effects: reconciling shaoyang, soothing the liver and regulating qi, lifting yang qi.

[0018] Aurantii Fructus Immaturus, bitter, pungent and sour in taste, warm in nature; attributing to the spleen and stomach meridians. Main effects: breaking qi to eliminate accumulation, resolving phlegm and dispersing stagnation.

[0019] White peony root, bitter and sour in taste, slightly cold in nature; it belongs to the liver and spleen meridians. Main effects: nourishing blood and regulating nutrient qi, astringing yin and stopping sweating, soothing the liver and alleviating pain, suppressing liver yang.

[0020] Licorice, sweet in taste and neutral in nature; it belongs to the spleen, stomach, lung, and heart meridians. Main effects: invigorating the spleen and replenishing qi, clearing heat and detoxifying, resolving phlegm and relieving cough, alleviating spasm and pain, coordinating the actions of various medicinal ingredients.

[0021] Cyperus rotundus, pungent, sweet, and slightly bitter in taste, neutral in nature; it belongs to the liver, spleen, and triple energizer meridians. Main effects: promoting qi circulation and relieving depression, regulating menstruation and alleviating pain.

[0022] The present invention is obtained by adding flavors and making modifications to the classical prescription Huoluo Xiaoling Dan (Angelica sinensis, Salvia miltiorrhiza, Olibanum, Myrrha) and the classical prescription Sini Powder (Bupleurum chinense, Fructus Aurantii Immaturus, Paeonia lactiflora, Licorice). Among them, the main effects of Huoluo Xiaoling Dan are activating blood circulation to dissipate stasis, reducing swelling and resolving masses, and dredging collaterals to relieve pain; the main effects of Sini Powder are soothing the liver and relieving depression, regulating the liver and spleen, and promoting qi circulation to relieve pain.

[0023] Furthermore, the compatibility of monarch, minister, assistant, and courier drugs in the present invention is as follows: The monarch drugs are Corydalis yanhusuo and Corydalis decumbens. The former has a strong effect of promoting qi circulation to relieve pain, and the latter has a strong effect of dredging collaterals to relieve pain. The two account for a relatively high proportion in the total weight parts of the formula. In the treatment of qi stagnation type cancer pain, blood stasis type cancer pain, and qi stagnation and blood stasis type cancer pain, they can jointly play the effects of the monarch drug, which is targeted at the main symptoms, has the strongest medicinal power, is used in a relatively large amount, dominates the direction of the prescription, and has a concise quantity. The first group of minister drugs: Bupleurum chinense soothes the liver, regulates qi, and relieves pain, Curcuma aromatica promotes qi circulation and relieves depression and pain, Fructus Aurantii Immaturus breaks qi to eliminate accumulation and relieve pain, Cyperus rotundus promotes qi circulation and relieves depression and pain, and they jointly assist the monarch drug Corydalis yanhusuo to enhance the effect of promoting qi circulation to relieve pain. The second group of minister drugs: Angelica sinensis nourishes blood, promotes blood circulation, and relieves pain, Salvia miltiorrhiza promotes blood circulation to remove stasis, regulates menstruation and relieves pain, Olibanum promotes blood circulation and qi circulation, dredges the channels and relieves pain, Myrrha promotes blood circulation and relieves pain, and they jointly assist the monarch drug Corydalis decumbens to enhance the effect of dredging collaterals to relieve pain; The assistant drug is Paeonia lactiflora, which restrains the pungency of the monarch drug; The courier drug is Licorice, which harmonizes the properties of the medicinal ingredients.

[0024] The novelty and creativity of the present invention are mainly reflected in the following aspects. 1. The formula structure of the present invention is significantly different from the original classical prescriptions Sini Powder and Huoluo Xiaoling Dan. The monarch drugs of the present invention are completely different from those of Sini Powder and Huoluo Xiaoling Dan, resulting in a different overall compatibility logic of the formula. 2. The dosage ratio of the formula of the present invention is significantly different from that of Sini Powder and Huoluo Xiaoling Dan. The dosage ratio relationship has a direct impact on the efficacy of the composition. The dosage ratio (by weight parts) of Sini Powder is equal parts, and the dosage ratio (by weight parts) of Huoluo Xiaoling Dan is also equal parts. The dosage ratio of the formula of the present invention is as described above, which is a non-obvious dosage ratio. 3. The drug compatibility of the present invention has a stronger overall synergistic effect compared with Sini Powder or Huoluo Xiaoling Dan, and its medicinal use for treating pain is more specific.

[0025] Furthermore, those skilled in the art can predict that the present invention has the effect of treating cancer pain based on the treatment principles of diseases or symptoms disclosed in the prior art and the effects or functions of each medicinal ingredient.

[0026] Among the 12 herbs in the present invention, none is toxic and the safety in use is high. Modern pharmacological studies have confirmed that 9 herbs in the formula, namely Curcuma aromatica Salisb., Angelica sinensis (Oliv.) Diels, Salvia miltiorrhiza Bunge, Olibanum, Myrrha, Bupleurum chinense DC., Paeonia lactiflora Pall., Glycyrrhiza uralensis Fisch., and Cyperus rotundus L., all have anti-tumor effects to a certain extent.

[0027] The present invention can treat moderate and severe cancer pain, and through the differentiation and treatment by Chinese medicine practitioners, it can also be used to treat moderate and severe non-cancer pain. Detailed implementation manners Example 1

[0028] A traditional Chinese medicine composition for treating cancer pain, comprising the following raw materials by weight: Corydalis yanhusuo 30 - 70 parts, Corydalis decumbens (Thunb.) Pers. 30 - 70 parts, Curcuma aromatica Salisb. 7 - 3 parts, Angelica sinensis (Oliv.) Diels 7 - 3 parts, Salvia miltiorrhiza Bunge 7 - 3 parts, Olibanum 10 - 6 parts, Myrrha 10 - 6 parts, Bupleurum chinense DC. 7 - 3 parts, Fructus Aurantii Immaturus 7 - 3 parts, Paeonia lactiflora Pall. 6 - 10 parts, Glycyrrhiza uralensis Fisch. 3 - 7 parts, and Cyperus rotundus L. 7 - 3 parts. Corydalis yanhusuo and Corydalis decumbens (Thunb.) Pers. account for 45.8% - 74.8% of the total weight of the formula. Example 2

[0029] A traditional Chinese medicine composition for treating cancer pain, comprising the following raw materials by weight: Corydalis yanhusuo 30 parts, Corydalis decumbens (Thunb.) Pers. 30 parts, Curcuma aromatica Salisb. 7 parts, Angelica sinensis (Oliv.) Diels 7 parts, Salvia miltiorrhiza Bunge 7 parts, Olibanum 10 parts, Myrrha 10 parts, Bupleurum chinense DC. 7 parts, Fructus Aurantii Immaturus 7 parts, Paeonia lactiflora Pall. 6 parts, Glycyrrhiza uralensis Fisch. 3 parts, and Cyperus rotundus L. 7 parts. Corydalis yanhusuo and Corydalis decumbens (Thunb.) Pers. account for 45.8% of the total weight of the formula. Example 3

[0030] A traditional Chinese medicine composition for treating cancer pain, comprising the following raw materials by weight: Corydalis yanhusuo 40 parts, Corydalis decumbens (Thunb.) Pers. 40 parts, Curcuma aromatica Salisb. 6 parts, Angelica sinensis (Oliv.) Diels 6 parts, Salvia miltiorrhiza Bunge 6 parts, Olibanum 9 parts, Myrrha 9 parts, Bupleurum chinense DC. 6 parts, Fructus Aurantii Immaturus 6 parts, Paeonia lactiflora Pall. 7 parts, Glycyrrhiza uralensis Fisch. 4 parts, and Cyperus rotundus L. 6 parts. Corydalis yanhusuo and Corydalis decumbens (Thunb.) Pers. account for 55.2% of the total weight of the formula. Example 4

[0031] A traditional Chinese medicine composition for treating cancer pain, comprising the following raw materials by weight: Corydalis yanhusuo 50 parts, Corydalis decumbens (Thunb.) Pers. 50 parts, Curcuma aromatica Salisb. 5 parts, Angelica sinensis (Oliv.) Diels 5 parts, Salvia miltiorrhiza Bunge 5 parts, Olibanum 8 parts, Myrrha 8 parts, Bupleurum chinense DC. 5 parts, Fructus Aurantii Immaturus 5 parts, Paeonia lactiflora Pall. 8 parts, Glycyrrhiza uralensis Fisch. 5 parts, and Cyperus rotundus L. 5 parts. Corydalis yanhusuo and Corydalis decumbens (Thunb.) Pers. account for 62.9% of the total weight of the formula. Example 5

[0032] A traditional Chinese medicine composition for treating cancer pain, comprising the following raw materials by weight: 60 parts of Corydalis yanhusuo, 60 parts of Corydalis decumbens, 4 parts of Curcuma aromatica, 4 parts of Angelica sinensis, 4 parts of Salvia miltiorrhiza, 7 parts of Olibanum, 7 parts of Myrrha, 4 parts of Bupleurum chinense, 4 parts of Aurantii Fructus Immaturus, 9 parts of Paeonia lactiflora, 6 parts of Glycyrrhiza uralensis, 4 parts of Cyperus rotundus. Corydalis yanhusuo and Corydalis decumbens account for 69.4% of the total weight of the formula. Example VI

[0033] A traditional Chinese medicine composition for treating cancer pain, comprising the following raw materials by weight: 70 parts of Corydalis yanhusuo, 70 parts of Corydalis decumbens, 3 parts of Curcuma aromatica, 3 parts of Angelica sinensis, 3 parts of Salvia miltiorrhiza, 6 parts of Olibanum, 6 parts of Myrrha, 3 parts of Bupleurum chinense, 3 parts of Aurantii Fructus Immaturus, 10 parts of Paeonia lactiflora, 7 parts of Glycyrrhiza uralensis, 3 parts of Cyperus rotundus. Corydalis yanhusuo and Corydalis decumbens account for 74.8% of the total weight of the formula.

[0034] All the features described in the specification and the appended claims, whether taken separately or in any combination thereof, are important features of the present invention.

[0035] Although the embodiments of the present invention have been shown and described above, it is obvious to those skilled in the art that the present invention is not limited to the details of the above embodiments. The above embodiments are exemplary and should not be construed as limiting the present invention. Without departing from the principles and purposes of the present invention, those of ordinary skill in the art can make changes, modifications, substitutions, deformations, delete some features, add features, and re-combine features within the scope of the present invention to form technical solutions. Any simple modification, equivalent change, and modification made to the above embodiments based on the innovative principles of the present invention still fall within the scope of the technical solutions of the present invention.

Claims

1. A Chinese medicine composition for treating cancer pain, characterized in that: The invention comprises the following raw materials in parts by weight: 30-70 parts of Corydalis yanhusuo, 30-70 parts of summer syrup, 7-3 parts of turmeric, 7-3 parts of angelica, 7-3 parts of salvia miltiorrhiza, 10-6 parts of frankincense, 10-6 parts of myrrh, 7-3 parts of bupleurum, 7-3 parts of immature bitter orange, 6-10 parts of white peony root, 3-7 parts of liquorice and 7-3 parts of cyperus rotundus.

2. The Chinese medicine composition for treating cancer pain according to claim 1, characterized in that: The raw materials and their weight portions are: 30 parts of Corydalis yanhusuo, 30 parts of summer osmanthus, 7 parts of curcuma, 7 parts of angelica, 7 parts of salvia miltiorrhiza, 10 parts of frankincense, 10 parts of myrrh, 7 parts of bupleurum, 7 parts of immature bitter orange, 6 parts of white peony, 3 parts of liquorice, and 7 parts of cyperus.

3. The Chinese medicine composition for treating cancer pain according to claim 1, characterized in that: The raw materials and their weight portions are: 40 parts of Corydalis yanhusuo, 40 parts of summer osmanthus, 6 parts of curcuma, 6 parts of angelica, 6 parts of salvia miltiorrhiza, 9 parts of frankincense, 9 parts of myrrh, 6 parts of bupleurum, 6 parts of immature bitter orange, 7 parts of white peony root, 4 parts of liquorice, and 6 parts of cyperus.

4. The Chinese medicine composition for treating cancer pain according to claim 1, characterized in that: The raw materials and their weight portions are: 50 parts of Corydalis yanhusuo, 50 parts of summer osmanthus, 5 parts of curcuma, 5 parts of angelica, 5 parts of salvia miltiorrhiza, 8 parts of frankincense, 8 parts of myrrh, 5 parts of bupleurum, 5 parts of immature bitter orange, 8 parts of white peony root, 5 parts of liquorice, and 5 parts of cyperus.

5. The Chinese medicine composition for treating cancer pain according to claim 1, characterized in that: The raw materials and their weight portions are: 60 parts of Corydalis yanhusuo, 60 parts of summer osmanthus, 4 parts of curcuma, 4 parts of angelica, 4 parts of salvia miltiorrhiza, 7 parts of frankincense, 7 parts of myrrh, 4 parts of bupleurum, 4 parts of immature bitter orange, 9 parts of white peony root, 6 parts of liquorice, and 4 parts of cyperus.

6. The Chinese medicine composition for treating cancer pain according to claim 1, characterized in that: The raw materials and their weight portions are: 70 parts of Corydalis yanhusuo, 70 parts of summer osmanthus, 3 parts of curcuma, 3 parts of angelica, 3 parts of salvia miltiorrhiza, 6 parts of frankincense, 6 parts of myrrh, 3 parts of bupleurum, 3 parts of aurantium immaturus, 10 parts of white peony root, 7 parts of liquorice, and 3 parts of cyperus rotundus.

7. The Chinese medicine composition for treating cancer pain according to any one of claims 1 to 6, characterized in that: It is used to treat cancer pain, and can also be used to treat other non-cancer pain through dialectical treatment by a Chinese medicine practitioner.

8. A Chinese medicine preparation for treating cancer pain, characterized in that: The Chinese medicine composition according to claims 1 to 7 is prepared by adding auxiliary materials required for preparation molding according to conventional methods for preparing preparations.

9. The Chinese medicine preparation according to claim 8, characterized in that: The compound preparation is in the form of decoction, powder, pill, granule, tablet, capsule or oral liquid.