Preparation method and application of medicinal garlic

Abstract

The invention discloses a preparation method and application of medicinal garlic. The preparation method comprises the following steps: S1, selection and treatment of garlic: selecting high-quality garlic and performing crushing treatment; s2, selecting and extracting traditional Chinese medicinal materials: selecting honeysuckle, fructus forsythiae, platycodon grandiflorum and liquorice, reasonably proportioning, and then preparing an extracting solution of the honeysuckle, the fructus forsythiae, the platycodon grandiflorum and the liquorice; s3, mixing and forming: uniformly mixing the garlic submicron powder with the traditional Chinese medicinal material extracting solution according to the proportion; and S4, preparation of a dosage form: preparing capsules or oral liquid as required. Through the synergistic effect of various components, the traditional Chinese medicine composition can relieve symptoms, can play roles in multiple aspects of antibiosis, antivirus, immunoregulation and the like, and has a more comprehensive overall treatment effect on lung diseases; in the aspects of improving the lung function of a patient and controlling long-term symptoms, the medicinal garlic preparation is equivalent to part of traditional medicines, and has the advantage in the aspect of improving the immunity of the organism.

Description

Technical Field

[0001] The present invention relates to the technical field of the treatment of respiratory system lung diseases, and specifically to a preparation method and application of medicated garlic. Background Art

[0002] Worldwide, a large number of people seek medical treatment or even lose their lives due to respiratory system lung diseases every year. Traditional treatment methods such as bronchodilators and glucocorticoids are used for the treatment of asthma and COPD, and antibiotics are used for lung infections. However, long-term use can cause various side effects, such as the decline in immunity and osteoporosis caused by hormones, and the problem of antibiotic resistance.

[0003] In terms of drug treatment, although chemically synthesized drugs can quickly relieve symptoms, the adverse reactions of long-term use have gradually emerged. Physical treatments such as oxygen inhalation and pulmonary rehabilitation training can only assist in improving symptoms and cannot cure the disease fundamentally. Surgical treatment is only applicable to specific types of lung diseases, such as early-stage lung cancer, and there are risks and postoperative complications. Therefore, it is urgent to develop a treatment plan based on natural ingredients, with few side effects and definite curative effects. For this reason, we propose a preparation method and application of medicated garlic. Summary of the Invention

[0004] The purpose of the present invention is to provide a preparation method and application of medicated garlic to solve the problems in the prior art.

[0005] To achieve the above purpose, the present invention provides the following technical solution: A preparation method of medicated garlic, comprising the following steps:

[0006] S1. Selection and treatment of garlic: Select high-quality garlic and perform pulverization treatment;

[0007] S2. Selection and extraction of Chinese medicinal materials: Select honeysuckle, forsythia, platycodon grandiflorum, and licorice and perform reasonable proportioning, and then prepare their extraction solution;

[0008] S3. Mixing and forming: Mix the garlic ultrafine powder and the extraction solution of Chinese medicinal materials evenly according to the proportion;

[0009] S4. Dosage form production: Prepare capsules or oral liquids according to needs.

[0010] Preferably, the selection and treatment of garlic in S1 specifically includes the following steps:

[0011] S11. Selection and cleaning: Select fresh and plump garlic, ensure that there is no damage or pests and diseases, and thoroughly clean to remove the dirt on the surface;

[0012] S12. Low-temperature drying: Use low-temperature drying technology to remove moisture without destroying the active ingredients in garlic;

[0013] S13. Ultrafine pulverization: The dried garlic is subjected to ultrafine pulverization to increase the specific surface area of the garlic, thereby improving the dissolution rate and bioavailability of the active ingredients.

[0014] Preferably, the low-temperature drying technology adopts freeze drying or vacuum drying.

[0015] Preferably, the selection and extraction of the Chinese medicinal materials in S2 specifically include the following steps:

[0016] S21. Medicinal material preparation: Mix honeysuckle, forsythia, platycodon root, and licorice according to the formula ratio;

[0017] S22. Soaking and heating reflux extraction: First soak the medicinal materials in water for a period of time, and then extract the active ingredients in the medicinal materials by heating reflux;

[0018] S23. Filtration and concentration: The extract is filtered and then concentrated to a certain volume;

[0019] S24. Alcohol precipitation treatment: Add an appropriate amount of ethanol to the concentrated solution, adjust the alcohol content to a specific ratio to precipitate the impurities; after standing and refrigerating, remove the precipitate to obtain a refined extract.

[0020] Preferably, for the preparation of capsules in S4: The materials mixed in S3 are dried and pulverized again, and then filled into capsule shells.

[0021] Preferably, for the preparation of oral liquid in S4: The materials mixed in S3 are further formulated and filtered, and then filled and sealed in appropriate containers and sterilized.

[0022] Preferably, the ratio of the Chinese medicinal materials is as follows: 10 - 15 grams of honeysuckle, 10 - 15 grams of forsythia, 6 - 10 grams of platycodon root, and 3 - 6 grams of licorice.

[0023] An application of medicated garlic, and the prepared medicated garlic is used to treat respiratory system lung diseases.

[0024] Compared with the prior art, the beneficial effects of the present invention are:

[0025] 1. Antibacterial and antiviral effects: Allicin and the active ingredients in the Chinese medicinal materials, such as chlorogenic acid in honeysuckle and phillyrin in forsythia, can damage the cell wall and cell membrane structures of bacteria, and inhibit the adsorption, invasion, and replication processes of viruses, thereby effectively killing the pathogens causing respiratory infections and reducing lung inflammation.

[0026] 2. Immunomodulatory effects: Components such as sulfur-containing compounds in garlic and glycyrrhizic acid in licorice can regulate the functions of immune cells in the body, enhance the phagocytic ability of macrophages, promote the proliferation and differentiation of lymphocytes, improve the body's immunity, and help the body resist lung diseases.

[0027] 3. Anti-inflammatory and anti-asthmatic effects: Components such as platycodin and glycyrrhetinic acid can inhibit the release of inflammatory mediators, reduce the inflammatory response of the respiratory mucosa, relieve bronchospasm, thereby achieving the effects of expectoration, cough relief, and asthma relief, and improving the ventilation function of the respiratory system.

[0028] 4. Through the synergistic action of multiple components, it can not only relieve symptoms, but also play roles in aspects such as antibacterial, antiviral, and immune regulation, and has a more comprehensive overall therapeutic effect on lung diseases; in improving the lung function of patients and long-term symptom control, the "medicinal garlic" preparation is comparable to some traditional drugs, and has advantages in enhancing the body's immunity.

[0029] 5. The "medicinal garlic" preparation is mainly composed of natural plant components. In clinical studies, the incidence of adverse reactions is low and the symptoms are mild, indicating its higher safety, especially suitable for patients with poor tolerance to traditional drugs or those with long-term medication needs. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] The drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation to the present invention. In the drawings:

[0031] Figure 1 is a flowchart of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0032] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present invention. Therefore, the following detailed description of the embodiments of the present invention provided in the drawings is not intended to limit the scope of the present invention to be protected, but merely represents the selected embodiments of the present invention.

[0033] Please refer to Figure 1 , in an embodiment of the present invention, a preparation method of medicinal garlic includes the following steps:

[0034] S1. Selection and treatment of garlic: Select high-quality garlic and crush it;

[0035] S2. Selection and extraction of Chinese medicinal materials: Select honeysuckle, forsythia, platycodon, and licorice and make a reasonable ratio, and then prepare their extraction solution; the ratio of the Chinese medicinal materials is as follows: 10-15 grams of honeysuckle, 10-15 grams of forsythia, 6-10 grams of platycodon, and 3-6 grams of licorice;

[0036] S3. Mixing and Molding: Mix the garlic ultrafine powder and the Chinese herbal medicine extract evenly according to the proportion.

[0037] S4. Dosage Form Preparation: Prepare capsules or oral liquids as needed. Preparation of capsules in S4: Redry and crush the material after mixing in S3, and then load it into the capsule shell. Preparation of oral liquids in S4: Further adjust, filter the material after mixing in S3, then seal it in an appropriate container and perform sterilization treatment.

[0038] The selection and treatment of garlic in S1 specifically include the following steps:

[0039] S11. Selection and Cleaning: Select fresh and plump garlic, ensure there is no damage or pests and diseases, and thoroughly clean it to remove the dirt on the surface.

[0040] S12. Low-temperature Drying: Use low-temperature drying technology to remove moisture without destroying the active ingredients in garlic.

[0041] S13. Ultrafine Grinding: Ultrafinely grind the dried garlic to increase the specific surface area of garlic, thereby improving the dissolution rate and bioavailability of the active ingredients.

[0042] Preferably, the low-temperature drying technology adopts freeze-drying or vacuum drying.

[0043] The selection and extraction of Chinese herbal medicines in S2 specifically include the following steps:

[0044] S21. Medicinal Material Preparation: Mix honeysuckle, forsythia, platycodon grandiflorum, and licorice according to the formula ratio.

[0045] S22. Soaking and Heating Reflux Extraction: Soak the medicinal materials in water for a period of time first, and then extract the active ingredients in the medicinal materials by heating reflux.

[0046] S23. Filtration and Concentration: The extract is filtered and then concentrated to a certain volume.

[0047] S24. Alcohol Precipitation Treatment: Add an appropriate amount of ethanol to the concentrated solution, adjust the alcohol content to a specific ratio to precipitate the impurities; remove the precipitate after standing and refrigerating to obtain a refined extract.

[0048] An application of medicated garlic, and the prepared medicated garlic is used to treat respiratory system lung diseases.

[0049] Main ingredients: Garlic, as the core ingredient, is rich in various bioactive substances such as allicin and sulfur-containing compounds. Research shows that allicin has powerful antibacterial, antiviral, and anti-inflammatory effects, and can effectively inhibit common pathogens causing respiratory infections, such as Streptococcus pneumoniae and influenza virus. At the same time, its sulfur-containing compounds can regulate the body's immune function and enhance the defense mechanism of the lungs.

[0050] Auxiliary ingredients: There are several traditional Chinese medicine ingredients such as honeysuckle, forsythia, platycodon grandiflorum, and licorice that are compatible with garlic. The chlorogenic acid, luteoloside, and other components contained in honeysuckle have the effects of clearing heat and detoxifying, dispersing wind and heat, and have a significant inhibitory effect on respiratory inflammation; phillyrin, forsythoside, etc. in forsythia can enhance the body's immune function and cooperate with honeysuckle to play an antiviral role; platycodin contained in platycodon grandiflorum can reduce phlegm and relieve cough, and promote the discharge of respiratory secretions; glycyrrhizic acid, glycyrrhetinic acid, and other components of licorice have anti-inflammatory, anti-allergic, cough-relieving, and asthma-relieving effects, and can also harmonize the properties of various drugs.

[0051] Experimental research and data analysis

[0052] I. In vitro experiments

[0053] Antibacterial experiment: Using the agar diffusion method, the extracts of "medicated garlic" were respectively applied to common respiratory pathogenic bacteria such as Streptococcus pneumoniae, Staphylococcus aureus, and Escherichia coli. The results showed that it had a significant inhibitory effect on common respiratory pathogenic bacteria, and the inhibitory effect was positively correlated with the concentration.

[0054] Antiviral experiment: Using the cytopathic effect inhibition method, MDCK cells were infected with influenza virus, and different concentrations of "medicated garlic" extracts were added. By observing the cytopathic effect and detecting the virus titer, it was found that the "medicated garlic" extract could significantly inhibit the replication of influenza virus and had good antiviral activity.

[0055] II. Animal experiments

[0056] Establishment of experimental model: Healthy mice were selected, and a mouse model of chronic obstructive pulmonary disease (COPD) was established by combining smoking with intratracheal injection of lipopolysaccharide (LPS). The mice were randomly divided into a model control group, a positive drug control group (given drugs for conventional treatment of COPD), and a "medicated garlic" treatment group.

[0057] Experimental procedures and index detection: In the "medicated garlic" treatment group, different doses of the "medicated garlic" preparation were given by gavage. The positive drug control group was given the corresponding drug, and the model control group was given an equal amount of normal saline. Medication was administered continuously for multiple weeks. After the experiment, lung function indexes of the mice were detected, such as forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and FEV1 / FVC ratio; pathological changes of lung tissues were observed, and alveolar structure and inflammatory cell infiltration were observed by hematoxylin-eosin (HE) staining; levels of inflammatory factors in serum and lung tissues were detected, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), etc.

[0058] Experimental results: Compared with the model control group, the lung function indexes of the mice in the "medicated garlic" treatment group were significantly improved, and the FVC, FEV1, and FEV1 / FVC ratios were significantly increased; pathological sections of lung tissues showed that the destruction of alveolar structure was reduced and the infiltration of inflammatory cells was decreased; levels of inflammatory factors such as TNF-α and IL-6 in serum and lung tissues were significantly reduced, and the effect of the high-dose "medicated garlic" treatment group was better than that of the low-dose group, and some indexes were comparable to those of the positive drug control group.

[0059] III. Clinical research

[0060] Research design: A randomized, double-blind, placebo-controlled clinical trial design was adopted. Multiple cases of respiratory system lung disease patients meeting the inclusion criteria were selected, including COPD patients, asthma patients, etc. The patients were randomly divided into an experimental group and a control group. The experimental group was given the "medicated garlic" preparation, and the control group was given a placebo with the same appearance. The treatment course was multiple weeks.

[0061] Observation indexes: The main observation indexes were the improvement of clinical symptoms after treatment, such as the score changes of symptoms such as cough, expectoration, and wheezing; lung function indexes, such as FEV1, FEV1 / FVC ratio, etc.; secondary observation indexes included quality of life score, occurrence of adverse reactions, etc.

[0062] Result analysis: After the treatment, the clinical symptom scores of the patients in the experimental group were significantly lower than those in the control group, and symptoms such as cough, expectoration, and wheezing were significantly relieved; lung function indexes FEV1 and FEV1 / FVC ratio were significantly improved compared with before treatment and were better than those in the control group; the quality of life score was also significantly improved. In terms of safety, the incidence of adverse reactions in the experimental group was not significantly different from that in the control group. The main adverse reactions were mild gastrointestinal discomfort, such as nausea, stomach discomfort, etc., and most of them could be relieved by themselves, indicating that the "medicated garlic" preparation has good safety and tolerance.

[0063] V. Comparative analysis

[0064] (I) Comparison with traditional therapeutic drugs

[0065] Efficacy comparison: Traditional drugs for treating respiratory lung diseases, such as bronchodilators, can quickly relieve the wheezing symptoms of asthma and COPD patients, but have limited effect on the fundamental control of inflammation; although glucocorticoids have significant anti-inflammatory effects, long-term use will bring many side effects. The patented "medicinal garlic" solution can not only relieve symptoms through the synergistic effect of multiple ingredients, but also play a role in aspects such as antibacterial, antiviral, and immune regulation, and has a more comprehensive overall therapeutic effect on lung diseases. Clinical studies have shown that in improving patients' lung function and long-term symptom control, the "medicinal garlic" preparation is comparable to some traditional drugs, and has advantages in enhancing the body's immunity.

[0066] Safety comparison: Side effects of traditional drugs are relatively common. For example, glucocorticoids can cause elevated blood sugar, osteoporosis, increased risk of infection, etc.; unreasonable use of antibiotics is likely to cause drug resistance problems. The "medicinal garlic" preparation is mainly composed of natural plant ingredients, and the incidence of adverse reactions in clinical studies is low and the symptoms are mild, indicating that it has higher safety, especially suitable for patients with poor tolerance to traditional drugs or those with long-term medication needs.

[0067] (2) Comparison with similar natural therapies

[0068] Differences in ingredients and action mechanisms: Some similar natural therapies on the market may only focus on a single efficacy. For example, some plant extracts only have antibacterial or immune regulatory effects. The patented "medicinal garlic" solution is based on traditional Chinese medicine theory and modern medical research, and scientifically combines garlic with a variety of Chinese medicinal materials to achieve the synergistic effect of antibacterial, antiviral, anti-inflammatory, and immune regulation, and the action mechanism is more comprehensive and in-depth.

[0069] Differences in clinical effects: Relevant comparative studies have shown that in improving the symptoms and lung function of patients with respiratory lung diseases, the "medicinal garlic" preparation has better effects than some natural therapies with single ingredients. For example, compared with a single plant extract, the "medicinal garlic" preparation can more significantly reduce the cough frequency and sputum volume of patients and improve the FEV1 level, which benefits from its unique formula and preparation process.

[0070] VI. Conclusion

[0071] (1) Research summary

[0072] The patented "medicinal garlic" solution for treating respiratory lung diseases demonstrates good antibacterial, antiviral, anti-inflammatory, and immune regulatory effects through its unique formula and advanced preparation process. In vitro experiments, animal experiments, and clinical studies have all shown that this solution has significant curative effects in the treatment of respiratory lung diseases, can effectively improve the clinical symptoms and lung function of patients, and has high safety and few adverse reactions. Compared with traditional therapeutic drugs and similar natural therapies, it has certain advantages and innovations.

[0073] (2) Application prospects

[0074] Clinical application: The "medicated garlic" preparation is expected to become a new option for the treatment of respiratory system lung diseases, especially suitable for the long-term treatment of mild to moderate patients and the rehabilitation assistance of severe patients. It can be widely applied to medical institutions at all levels to provide safer and more effective treatment means for patients.

[0075] Market potential: With the continuous increase in people's attention to health and natural medicines, the patented "medicated garlic" products have broad market prospects. It can be developed into various dosage forms, such as capsules, oral liquids, etc., to meet the needs of different patients. It can not only be sold in the domestic market but also be expanded to the international market, bringing new economic growth points to the field of respiratory system lung disease treatment.

[0076] Finally, it should be noted that the above are only the preferred embodiments of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions recorded in the foregoing embodiments or perform equivalent replacements on some of the technical features. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A method for preparing medicinal garlic, characterized in that: The following steps are involved: S1. Selection and processing of garlic: Select high-quality garlic and crush it; S2. Selection and extraction of Chinese medicinal materials: select honeysuckle, forsythia, platycodon grandiflorum, and liquorice and make reasonable proportions, and then prepare their extracts; S3, mixing and molding: uniformly mixing the garlic ultrafine powder and the Chinese medicinal material extract according to a proportion; S4. Dosage form preparation: Prepare capsules or oral liquid as needed.

2. The method for preparing medicinal garlic according to claim 1, wherein The selection and processing of the S1 garlic specifically comprises the following steps: S11. Selection and cleaning: Select fresh and plump garlic, make sure it is free of damage or pests, and clean it thoroughly to remove surface dirt; S12. Low temperature drying: Use low temperature drying technology to remove moisture without destroying the active ingredients in garlic; S13. Ultrafine grinding: ultrafinely grind the dried garlic to increase the specific surface area of ​​the garlic.

3. The method for preparing medicinal garlic according to claim 2, wherein: The low-temperature drying technology adopts freeze drying or vacuum drying.

4. The method for preparing medicinal garlic according to claim 1, wherein The selection and extraction of the S2 Chinese medicinal materials specifically include the following steps: S21. Preparation of medicinal materials: Mix honeysuckle, forsythia, platycodon and liquorice according to the formula ratio; S22, soaking and heating reflux extraction: first soak the medicinal materials in water for a period of time, and then extract the effective ingredients in the medicinal materials by heating reflux; S23, filtration and concentration: the extract is filtered and then concentrated to a certain volume; S24, alcohol precipitation treatment: add a proper amount of ethanol to the concentrated solution, adjust the alcohol content to a specific ratio, and precipitate impurities; remove the precipitate after standing and refrigerating to obtain a refined extract.

5. The method for preparing medicinal garlic according to claim 1, wherein: Preparation of the capsule in S4: The mixed materials in S3 are dried and crushed again, and then filled into capsule shells.

6. The method for preparing medicinal garlic according to claim 1, wherein: Preparation of the oral liquid in S4: The mixed materials in S3 are further prepared and filtered, then filled into a suitable container and sterilized.

7. The method for preparing medicinal garlic according to claim 1, wherein: The ratio of the Chinese medicinal materials is as follows: 10-15 grams of honeysuckle, 10-15 grams of forsythia, 6-10 grams of platycodon, and 3-6 grams of liquorice.

8. An application of medicinal garlic, characterized in that, A method for preparing medicinal garlic according to any one of claims 1 to 7 is used, and the prepared medicinal garlic is used to treat respiratory system lung diseases.

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