Soothing composition and application thereof in cosmetics

Abstract

The invention provides a soothing composition and application thereof in cosmetics, the soothing composition is composed of LIPOCIRE A PELLETS, Ectoine, a centella asiatica extract, Symcalmin, a purslane extract and panthenol, the composition utilizes a non-soothing component LIPOCIRE A PELLETS to be combined with a plurality of soothing active components, the action effect of each soothing component is fully exerted, human body tests show that the soothing composition has the effect of relieving the pain of a human body, and the soothing composition has the effect of relieving the pain of the human body. The composition can significantly improve the water content of the skin cuticle, reduce the skin transdermal water loss rate and the skin color a * value, and has significant synergistic effects in improving the moisturizing, repairing, soothing and other aspects of the soothing components.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and particularly relates to a soothing composition and its application in cosmetics. Background Art

[0002] In recent years, with the deterioration of the earth's living environment and the increase in people's life pressure, the number of people with skin allergies has been increasing, accompanied by phenomena such as skin tightness, itching, stinging, and redness. Skin allergies generally involve damaged skin barriers, making people more vulnerable to external stimuli than the normal population. The inflammatory reactions caused by the stimuli will further exacerbate the damage of the skin barrier, thus forming a vicious cycle. Therefore, a composition with good soothing effect has become an increasingly important part of the research and development of skin care products.

[0003] Common soothing substances include panthenol, purslane extract, centella asiatica extract, dipotassium glycyrrhizinate, and allantoin, etc. Panthenol can achieve a soothing effect by inhibiting the secretion of inflammatory mediators IL-1α and prostaglandin PGE2; allantoin can inhibit the release of inflammatory mediators, reduce the body's inflammatory response, and relieve pain symptoms; dipotassium glycyrrhizinate acts on hormone receptors to participate in regulation, reduce the secretion level of vascular endothelial growth factor (VEGF), and down-regulate the mRNA expression of transient receptor potential vanilloid 1 (TRPV1) and cyclooxygenase (COX-2), thereby reducing the release of inflammatory factors. Purslane is rich in antioxidants, which can neutralize free radicals, reduce the damage of oxidative stress to the skin, and thus reduce the inflammatory response; at the same time, certain components in the purslane extract can inhibit the release of pro-inflammatory cytokines, such as TNF-α and IL-6, thereby reducing the skin's inflammatory response. Centella asiatica extract can reduce the production of inflammatory mediators by inhibiting the NF-κB signaling pathway, effectively controlling skin inflammation.

[0004] Patent document CN113197836A discloses a soothing and antipruritic skin care composition, which includes folic acid, peony root extract, centella asiatica leaf extract, purslane flower / leaf / stem extract, and sophora flavescens root extract; patent document CN116172919A discloses a soothing and repairing composition and its application in cosmetics, and the soothing and repairing composition includes the following components: bryophyllum pinnatum leaf extract, oatrim, centella asiatica extract, purslane extract, dipotassium glycyrrhizinate, ectoine, and D-panthenol, so as to achieve the purpose of improving skin conditions, soothing the skin, and strengthening the skin barrier; patent document CN115501127A discloses an anti-inflammatory and anti-allergic composition, including 0.05-3 parts by weight of 60 parts by weight of polyhydroxypropyl arginine and its derivatives, 1 - 7 parts by weight of trehalose, 3 - 12 parts by weight of SRC, 0.5 - 2 parts by weight of ergot thioneine thalictrum extract, 5 - 50 parts by weight of purslane extract, 3 - 8 parts by weight of collagen peptide, and deionized water is added to make up 100 parts by weight. In the above patent applications, one or more combinations of soothing substances are generally used, and the soothing raw materials are directly applied to cosmetics. However, the combined effects of several soothing raw materials not only do not show obvious synergistic effects, but also result in incomplete exertion of the effects of each soothing substance and low bioavailability. There is no report on the research of combining soothing substances with components without soothing activity to improve the soothing effect of the composition.

[0005] Therefore, providing a soothing composition that combines soothing components and non-soothing components to promote the action of soothing components by non-soothing components and enhance the anti-inflammatory and soothing effect of the composition is of great significance for improving the utilization rate of soothing raw materials. Summary of the Invention

[0006] The purpose of the present invention is to provide a soothing composition and its application in cosmetics. The composition includes LIPOCIRE A PELLETS, ectoin, panthenol, Symcalmin, purslane extract, and centella asiatica extract. The composition combines LIPOCIRE A PELLETS with soothing active components to effectively exert the anti-inflammatory and soothing effects of soothing substances, and the composition has a significant synergistic effect in increasing the water content of the skin stratum corneum and reducing the transdermal water loss rate of the skin.

[0007] To achieve the above purpose, the present invention adopts the following technical solutions:

[0008] On the one hand, the present invention provides a soothing composition, including LIPOCIRE A PELLETS and soothing raw materials. The soothing raw materials include ectoin, centella asiatica extract, Symcalmin, purslane extract, and panthenol.

[0009] In existing commercially available skin care products, in order to improve the anti-inflammatory skin care effect of the products, most of their formulations add a variety of anti-inflammatory and soothing substances, such as extracts of Portulaca oleracea, Centella asiatica, Glycyrrhiza glabra and other extracts, and panthenol, etc. However, the addition of a variety of soothing substances does not effectively play the role of each of these substances, and the anti-inflammatory and soothing effect of the products is still limited. Therefore, in order to fully exert the effect of the soothing substances, the present invention innovatively adds LIPOCIRE A PELLETS to the formulation of the soothing composition and uses it in combination with a variety of soothing raw materials. It is found that after adding a composition composed of LIPOCIRE A PELLETS, ectoin, Centella asiatica extract, Symcalmin, Portulaca oleracea extract and panthenol to the skin care cream, it can effectively improve the effect of the cream in terms of skin moisturization, repair and soothing.

[0010] LIPOCIRE A PELLETS (triglycerides of C10-18 fatty acids) is a special skin care raw material, and it has also been applied to the preparation raw materials in existing skin care products, but the addition ratio is very small and it plays a role as an auxiliary agent. The present invention uses ectoin, Centella asiatica extract, Symcalmin, Portulaca oleracea extract and panthenol as soothing raw materials and combines them with LIPOCIRE A PELLETS. It is found that the composition has a significant synergistic effect in increasing the moisture content of the skin stratum corneum, reducing the transdermal water loss rate and reducing inflammation. The reason may be that ectoin can bind water molecules and form a hydrated layer in the extracellular space, and the Centella asiatica extract can also improve the hydration ability of the skin and help maintain the moist state of the skin. At the same time, both ectoin and Centella asiatica extract have anti-inflammatory properties, can inhibit the release of inflammatory factors, and quickly relieve skin discomfort. The main active ingredient of the said Symcalmin is dihydrooat alkaloid. When used as a soothing substance, it can reduce the damage of free radicals to the skin, inhibit the release of pro-inflammatory mediators, and reduce the inflammatory response. The Portulaca oleracea extract is rich in a variety of bioactive substances, mainly including flavonoid compounds such as quercetin and kaempferol, polysaccharides, amino acids, organic acids and vitamins, etc. The above-mentioned various substances play an important role in antioxidant and maintaining skin moisture, etc. Panthenol, as a soothing raw material, can not only absorb moisture in the air and lock it on the skin surface to keep the skin moist, but also promote the generation of stratum corneum lipids, enhance the skin barrier function, and inhibit the release of inflammatory mediators, which helps to soothe sensitive and inflamed skin. The said 5 soothing raw materials all have good effect in skin moisturization, barrier repair and skin soothing, and the synergistic effect of the soothing raw materials and LIPOCIRE A PELLETS improves the moisturization, repair and soothing effects of the composition.

[0011] In some embodiments, the present invention has proven through experiments that compared with a cream containing only 5 soothing raw materials such as ectoin, centella asiatica extract, Symcalmin, portulaca oleracea extract, and panthenol, the soothing cream prepared from the composition composed of LIPOCIRE A PELLETS and soothing raw materials has more prominent effects in skin moisturization, repair, and soothing. The reason may be that in the soothing composition, LIPOCIRE A PELLETS has good skin affinity, which can help the soothing raw materials better penetrate into the skin surface layer and enhance their bioavailability; at the same time, LIPOCIRE A PELLETS can promote the absorption of the soothing raw materials by softening the cutin layer, thereby improving their efficacy. In addition, LIPOCIRE A PELLETS itself has certain moisturizing and repair effects, and can act synergistically with the soothing raw materials, thereby enhancing the soothing effect of the overall formulation. For the soothing cream without LIPOCIRE A PELLETS, the effects of various soothing raw materials are not fully exerted and the bioavailability is low. Therefore, its moisturizing, soothing and other effects are not as good as those of the soothing cream prepared from the soothing composition provided by the present invention.

[0012] In some embodiments, the soothing raw materials include but are not limited to ectoin, panthenol, Symcalmin, portulaca oleracea extract, and centella asiatica extract. LIPOCIRE A PELLETS can make each soothing active ingredient be fully utilized and maximize the role of the soothing substance in multiple ways such as enhancing the permeability of the soothing raw materials, improving the texture of the skin care product, and acting synergistically with the soothing raw materials, significantly improving the effect and utilization rate of the soothing raw materials.

[0013] Furthermore, by weight percentage, the contents of LIPOCIRE A PELLETS, ectoin, centella asiatica extract, Symcalmin, portulaca oleracea extract, and panthenol are 1-10%, 0.1-1.5%, 0.5-2%, 0.05-1%, 0.05-1%, 0.3-2%, 0.5-5%.

[0014] On the other hand, the present invention provides a soothing product, including the soothing composition as described above.

[0015] The research results of the present invention prove that, compared with the soothing cream prepared from matrixes such as oil emollients and auxiliaries commonly used in the preparation of skin care products and the cream products without the LIPOCIRE A PELLETS ingredient or only containing the LIPOCIRE A PELLETS ingredient, the soothing cream prepared from the soothing composition has better effects, further proving the necessity of using LIPOCIRE A PELLETS in combination with soothing raw materials and the obvious synergistic effect between LIPOCIRE A PELLETS and soothing active ingredients.

[0016] The soothing composition provided by the present invention can be appropriately combined with various ingredients commonly used in the fields of cosmetics and quasi-drugs as needed within the scope that does not damage the effects of the present invention, such as powder ingredients, moisturizers, thickeners, metal ion masking agents, pigments, pH regulators, skin nutrients, vitamins, preservatives, antioxidants, antioxidant aids, fragrances, etc.

[0017] On the other hand, the present invention provides the use of a composition for preparing a skin care reagent with a moisturizing effect by increasing the water content of the skin stratum corneum, wherein the composition includes LIPOCIRE A PELLETS and soothing raw materials, and the soothing raw materials include ectoin, centella asiatica extract, Symcalmin, portulaca oleracea extract and panthenol.

[0018] Furthermore, by weight percentage, the contents of the LIPOCIRE A PELLETS, ectoin, centella asiatica extract, Symcalmin, portulaca oleracea extract and panthenol are 1-10%, 0.1-1.5%, 0.5-2%, 0.05-1%, 0.05-1%, 0.3-2%, 0.5-5%.

[0019] On the other hand, the present invention provides the use of a composition for preparing a reagent for repairing the skin barrier by reducing the transepidermal water loss rate of the skin, wherein the composition includes LIPOCIRE A PELLETS, ectoin, centella asiatica extract, Symcalmin, portulaca oleracea extract and panthenol.

[0020] Furthermore, by weight percentage, the contents of the LIPOCIRE A PELLETS, ectoin, centella asiatica extract, Symcalmin, portulaca oleracea extract and panthenol are 1-10%, 0.1-1.5%, 0.5-2%, 0.05-1%, 0.05-1%, 0.3-2%, 0.5-5%.

[0021] On the other hand, the present invention provides the use of a composition for preparing a reagent for soothing skin flushing by reducing the skin color a* value, and the composition comprises LIPOCIRE A PELLETS, ectoin, Centella asiatica extract, Symcalmin, Portulaca oleracea extract and panthenol.

[0022] Further, by weight percentage, the contents of LIPOCIRE A PELLETS, ectoin, Centella asiatica extract, Symcalmin, Portulaca oleracea extract and panthenol are 1-10%, 0.1-1.5%, 0.5-2%, 0.05-1%, 0.05-1%, 0.3-2%, 0.5-5%.

[0023] On the other hand, the present invention provides the use of LIPOCIRE A PELLETS for preparing a soothing composition for improving the moisturizing, repairing and soothing effects of soothing raw materials, the soothing raw materials comprising ectoin, Centella asiatica extract, Symcalmin, Portulaca oleracea extract and panthenol, and the soothing composition comprising LIPOCIRE A PELLETS, ectoin, Centella asiatica extract, Symcalmin, Portulaca oleracea extract and panthenol.

[0024] In some embodiments, the present invention proves through a large number of experimental studies that only when LIPOCIRE A PELLETS are used in combination with five soothing raw materials, namely ectoin, Centella asiatica extract, Symcalmin, Portulaca oleracea extract and panthenol, can significant synergistic effects be achieved in terms of moisturizing, repairing and soothing. If any one of the soothing substances is missing in the composition, the effect is not obvious; and the combination of soothing raw materials without the LIPOCIRE A PELLETS component will also result in a low effect due to the incomplete exertion of the effects of various soothing substances.

[0025] The present invention has the following beneficial effects:

[0026] 1. The present invention provides a soothing composition, which combines the non-soothing raw material LIPOCIRE A PELLETS with a variety of soothing raw materials, and has significant synergistic effects in increasing the water content of the skin stratum corneum, reducing the transepidermal water loss rate of the skin and anti-inflammatory soothing.

[0027] 2. The soothing composition provided by the present invention uses LIPOCIRE A PELLETS to repair the skin barrier and improve the skin resistance. When used in combination with the soothing raw materials, the effects of the soothing raw materials are fully exerted, and the bioavailability of the soothing raw materials is improved.

[0028] 3. The formula composition is simple, the raw materials are easy to obtain, the product is mild and non-irritating, and can be used for a long time. Description of the Drawings

[0029] Figure 1 These are the test results of the water content in the skin stratum corneum.

[0030] Figure 2 These are the test results of the transepidermal water loss rate of the skin.

[0031] Figure 3 These are the test results of the a* value of the skin color. Specific Embodiments

[0032] The present invention will be further described in detail below in conjunction with embodiments. It should be noted that the following embodiments are intended to facilitate the understanding of the present invention and do not impose any limitations on it. Unless otherwise specified, the raw materials used in the embodiments are obtained by purchasing commercially available products.

[0033] Example 1. Preparation of a soothing cream ① using the soothing composition provided by the present invention

[0034] Soothing cream ① is prepared from a soothing composition (active ingredient) composed of LIPOCIRE A PELLETS (purchased from Shanghai Pu'en Biochemical Technology Co., Ltd.), ectoin (purchased from Shenzhen Redlin Biotechnology Co., Ltd.), centella asiatica extract (purchased from Shanghai Ruidian Biotechnology Co., Ltd.), Symcalmin (purchased from Symrise Flavors & Fragrances (Nantong) Co., Ltd.), portulaca oleracea extract (purchased from Shanghai Baihaobo Biotechnology Co., Ltd.) and panthenol (purchased from Shanghai Baihaobo Biotechnology Co., Ltd.) and a matrix component. The matrix component is used as a solvent to dissolve the active ingredient, has no moisturizing or soothing effect, and does not affect the effect of the active ingredient. The components and their addition ratios are shown in Table 1. The preparation method is as follows:

[0035] Mix raw materials 1 - 7 and 13 evenly and heat to 80°C; heat raw materials 8 - 12 and 16 to 80°C to ensure complete melting. Then add the oil-phase raw materials to the water phase and homogenize for 5 - 8 min until the material is uniform and delicate, and start to cool down. Preheat raw materials 14 and 15 to 50°C and stir until transparent and homogeneous. When the material cools down to 45°C, add raw materials 14, 15, 17 - 21 and stir until uniform. When the temperature drops to 35 - 40°C, discharge the material.

[0036] Table 1 Formula of Soothing Cream ①

[0037]

[0038]

[0039] Example 2. Preparation of a soothing cream ② using the soothing composition provided by the present invention

[0040] The difference in the formulation ingredients of the Soothing Cream ② from those of Example 1 lies in that the addition ratio of the raw material LIPOCIRE A PELLETS is 6%, and its preparation method is basically the same as that of Example 1.

[0041] Example 3. The soothing composition provided by the present invention is used to prepare Soothing Cream ③

[0042] The difference in the formulation ingredients of the Soothing Cream ③ from those of Example 1 lies in that the addition ratio of the raw material LIPOCIRE A PELLETS is 10%, and its preparation method is basically the same as that of Example 1.

[0043] Comparative Example 1. LIPOCIRE A PELLETS is not added

[0044] The difference in the formulation ingredients of the soothing cream from those of Example 1 lies in that the raw material LIPOCIRE A PELLETS is not added, and the remaining ingredients and their ratios are the same as those in Table 1, and the preparation method is basically the same as that of Example 1.

[0045] Comparative Example 2. Soothing raw materials are not added

[0046] The difference in the formulation ingredients of the soothing cream from those of Example 1 lies in that the soothing raw materials ectoin, centella asiatica extract, Symcalmin, portulaca oleracea extract and panthenol are not added, and the remaining ingredients and their ratios are the same as those in Table 1, and the preparation method is basically the same as that of Example 1.

[0047] Comparative Example 3. Neither LIPOCIRE A PELLETS nor soothing raw materials are added

[0048] The difference in the formulation ingredients of the soothing cream from those of Example 1 lies in that the soothing composition composed of LIPOCIRE A PELLETS, ectoin, centella asiatica extract, Symcalmin, portulaca oleracea extract and panthenol is not added, and the matrix ingredients and their ratios are the same as those in Table 1, and the preparation method is basically the same as that of Example 1.

[0049] Comparative Example 4. Ectoin is not added

[0050] The difference in the formulation ingredients of the soothing cream from those of Example 1 lies in that ectoin is not added, and the remaining ingredients and their ratios are the same as those in Table 1, and the preparation method is basically the same as that of Example 1.

[0051] Comparative Example 5. Centella asiatica extract is not added

[0052] The difference in the formulation ingredients of the soothing cream from those of Example 1 lies in that centella asiatica extract is not added, and the remaining ingredients and their ratios are the same as those in Table 1, and the preparation method is basically the same as that of Example 1.

[0053] Comparative Example 6. Symcalmin is not added

[0054] The formulation components of the soothing cream are different from those of Example 1 in that Symcalmin is not added, and the remaining components and proportions are the same as in Table 1. The preparation method is basically the same as that of Example 1.

[0055] Comparative Example 7: Portulaca oleracea extract is not added

[0056] The formulation components of the soothing cream are different from those of Example 1 in that Portulaca oleracea extract is not added, and the remaining components and proportions are the same as in Table 1. The preparation method is basically the same as that of Example 1.

[0057] Comparative Example 8: Panthenol is not added

[0058] The formulation components of the soothing cream are different from those of Example 1 in that panthenol is not added, and the remaining components and proportions are the same as in Table 1. The preparation method is basically the same as that of Example 1.

[0059] Comparative Example 9: Ectoin is added

[0060] The formulation components of the soothing cream are different from those of Example 1 in that only ectoin in the soothing composition is added, and the matrix components and proportions are the same as in Table 1. The preparation method is basically the same as that of Example 1.

[0061] Comparative Example 10: Centella asiatica extract is added

[0062] The formulation components of the soothing cream are different from those of Example 1 in that only Centella asiatica extract in the soothing composition is added, and the matrix components and proportions are the same as in Table 1. The preparation method is basically the same as that of Example 1.

[0063] Comparative Example 11: Symcalmin is added

[0064] The formulation components of the soothing cream are different from those of Example 1 in that only Symcalmin in the soothing composition is added, and the matrix components and proportions are the same as in Table 1. The preparation method is basically the same as that of Example 1.

[0065] Comparative Example 12: Portulaca oleracea extract is added

[0066] The formulation components of the soothing cream are different from those of Example 1 in that only Portulaca oleracea extract in the soothing composition is added, and the matrix components and proportions are the same as in Table 1. The preparation method is basically the same as that of Example 1.

[0067] Comparative Example 13: Panthenol is added

[0068] The formulation components of the soothing cream are different from those of Example 1 in that only panthenol in the soothing composition is added, and the matrix components and proportions are the same as in Table 1. The preparation method is basically the same as that of Example 1.

[0069] Test Example: Moisturizing and soothing effect tests of the soothing cream

[0070] The soothing creams prepared in Examples 1 to 3 and Comparative Examples 1 to 13 were respectively used for testing the water content of the skin stratum corneum. The specific experimental method was as follows: A total of 35 subjects with healthy skin and no history of cosmetic allergy, aged 18 - 60 years old, were recruited. According to the 16 groups of samples in Examples 1 - 3 and Comparative Examples 1 - 13, 16 test areas of 4*4 cm were marked on the forearms of the subjects. 2 The Corneometer CM825 probe of CK Company in Germany was used to measure the water content of the stratum corneum in each test area before applying the sample, 15 minutes, 2 hours, and 4 hours after applying the sample. The application amount of the corresponding sample was 2 mg / cm 2 . The test environment was at a temperature of 20 - 22 °C and a humidity of 40 - 60%. The test results are shown in Table 1, in which Figure 1 the test results of Examples 1 - 3 and Comparative Examples 1 - 3 are shown.

[0071] Table 1 Changes in the water content of the skin stratum corneum after using different soothing creams

[0072]

[0073] As shown in the results of Table 1, there was no obvious change in the water content of the skin stratum corneum after using the sample in Comparative Example 3, indicating that among the matrix components of the cream except LIPOCIRE A PELLETS and the soothing raw materials, other matrix components had no effect on the water content of the skin stratum corneum. Compared with after modeling (0 h), the creams prepared from a single LIPOCIRE A PELLETS, ectoin, Centella asiatica extract, Symcalmin, Portulaca oleracea extract, or panthenol raw material (Comparative Examples 2, 9 - 13) could increase the water content of the skin stratum corneum to a certain extent. After using the sample for 2 hours, the water content of the stratum corneum increased by 19.14%, 27.82%, 22.87%, 28.62%, 26.90%, and 22.48% respectively, and after using the sample for 4 hours, it increased by 15.00%, 25.54%, 23.75%, 23.56%, 27.54%, and 19.31% respectively. The change in the water content of the skin stratum corneum was relatively small.

[0074] Comparing Examples 1-3 with Comparative Examples 1, 3-8, it can be found that the facial creams prepared using the soothing composition (Examples 1-3) composed of LIPOCIRE A PELLETS and soothing raw materials can significantly increase the water content of the skin stratum corneum. After using the samples for 2 h, the water content of the skin stratum corneum increased by 131.18%, 147.78% and 207.68% respectively compared with that before use; after using the samples for 4 h, they increased by 123.31%, 156.22% and 201.35% respectively. However, the facial creams prepared after combining any one of the soothing raw materials with LIPOCIRE A PELLETS (Comparative Examples 4-8) or the facial creams prepared only from soothing raw materials (Comparative Example 1) are not as effective as the soothing facial creams of Examples 1-3 in increasing the water content of the skin stratum corneum. After using the samples of Comparative Examples 1, 4-8 for 2 h, the water content of the skin stratum corneum increased by 38% - 45%; after using for 4 h, it increased by about 33% - 43%, indicating that the effect of combining LIPOCIRE A PELLETS with 5 kinds of soothing raw materials is better than that of simply stacking 5 kinds of soothing raw materials. The reason may be that the non-soothing raw material LIPOCIRE A PELLETS has good skin affinity and can help the soothing raw materials better penetrate into the skin surface layer, enhancing their bioavailability. At the same time, according to the results of Comparative Example 2, when both LIPOCIRE A PELLETS and soothing raw materials are missing in the preparation raw materials of the soothing facial cream, there is still no obvious change in the water content of the skin stratum corneum after using the sample, and the level is the lowest.

[0075] The above results show that the soothing facial creams prepared with a single LIPOCIRE A PELLETS component or one soothing raw material generally have a general effect in increasing the water content of the skin stratum corneum; if any one of the soothing raw materials or LIPOCIRE A PELLETS is missing in the soothing composition, its effect is also not as good as the soothing composition provided by the present invention. Only by using the combination of LIPOCIRE A PELLETS and 5 kinds of soothing raw materials can a significant synergistic effect be achieved in increasing the water content of the skin stratum corneum.

[0076] The present invention further evaluated the anti-inflammatory and soothing effects of the soothing facial cream. The skin barrier on the flexor side of both forearms was damaged by tearing with 3M hypoallergenic tape to establish a barrier damage symptom model, and then the soothing facial creams of Examples 1-3 and Comparative Examples 1-13 were used to repair the test areas of the test population. The Tewameter TM Hex and Colorimeter CL400 probes of CK Company in Germany were used to measure the transepidermal water loss rate and the skin color a* value of each test area after modeling, 15 min, 2 h, and 4 h after applying the sample, and the application amount of the corresponding sample was 2 mg / cm 2, the test environment was at a temperature of 20 - 22°C and a humidity of 40 - 60%. The test results are shown in Tables 2 and 3, where Figure 2 and Figure 3 respectively show the test results of the trans-epidermal water loss rate and the skin color a* value of Example 2 and Comparative Examples 1 - 3.

[0077] Table 2 Changes in the trans-epidermal water loss rate of the skin after using different soothing creams

[0078]

[0079]

[0080] From the test data of the trans-epidermal water loss rate of the skin, it can be seen that after using the soothing creams prepared in Examples 1 - 3 and Comparative Examples 1 - 13, only the trans-epidermal water loss rate of the skin in Comparative Example 3 increased slightly after skin barrier damage. Compared with after modeling (0 h), the average trans-epidermal water loss rate of the skin in the test area decreased in other groups, indicating that all 15 groups of test samples had a certain repair effect. Among them, the reduction amplitude of the trans-epidermal water loss rate of the skin after using the soothing creams prepared in Examples 1 - 3 was the most significant. After using for 2 h, the trans-epidermal water loss rates decreased by 38.51%, 42.36%, and 44.03% respectively; after using for 4 h, they decreased by 37.10%, 39.64%, and 43.40% respectively. For the creams prepared with any one ingredient (Comparative Examples 2, 9 - 13), the trans-epidermal water loss rates decreased by 3.69%, 6.56%, 2.79%, 4.67%, 5.86%, and 7.91% respectively after 4 h; for the creams prepared with any 4 soothing raw materials combined with LIPOCIRE APELLETS or only combined with 5 soothing raw materials (Comparative Examples 1, 4 - 8), the trans-epidermal water loss rates decreased by 13.16%, 20.33%, 21.97%, 23.46%, and 21.13% respectively after 4 h, indicating that the repair effect of a single soothing raw material was limited, and there was no obvious difference between the effect of combining 4 soothing raw materials with LIPOCIRE A PELLETS and the effect of only combining soothing raw materials. Their role in reducing the trans-epidermal water loss rate was not obvious. Only by combining LIPOCIRE APELLETS with 5 soothing raw materials could the trans-epidermal water loss rate of the skin be significantly reduced, achieving a synergistic effect.

[0081] Table 3 Changes in the skin color a* value after using different soothing creams

[0082]

[0083]

[0084] From the test data of the skin color a* value, it can be seen that compared with after modeling, for the soothing creams prepared by adding a soothing composition (Examples 1-3) composed of LIPOCIRE APELLETS and 5 soothing raw materials, the skin color a* value of the test area decreased most significantly after use. The change rates after 2 hours were -39.03%, -44.89%, and -47.69% in sequence, and the change rates after 4 hours were -35.31%, -36.70%, and -47.10% in sequence. For the creams prepared only with 5 soothing raw materials or lacking any one of the soothing raw materials (Comparative Examples 1, 4-8), compared with Examples 1-3, the reduction amplitude of the skin color a* value was reduced. After using for 2 hours, the skin color a* values decreased by 4.91%, 10.65%, 14.23%, 16.93%, 12.43%, and 15.43% respectively, and after using for 4 hours, the skin color a* values decreased by 5.39%, 9.20%, 11.84%, 10.79%, 8.15%, and 7.34% respectively. It can be found that the change amount of Comparative Example 1 was smaller than that of Comparative Examples 4-8. It is speculated that the reason may be that the combined use of 5 soothing raw materials did not fully exert the effect of each soothing ingredient, while the combination of LIPOCIRE APELLETS and soothing raw materials can promote the full play of each soothing substance. Only by using the combination of LIPOCIRE A PELLETS and 5 soothing raw materials can a significant synergistic effect be achieved. Without any one of the soothing substances in the combination, the soothing effect is not obvious.

[0085] The above is only the specific implementation manner of the present invention, but the design concept of the present invention is not limited thereto. Any non-substantive modification made to the present invention using this concept shall fall within the scope of infringement of the protection of the present invention.

Claims

1. A soothing composition, characterized in that Includes LIPOCIRE A PELLETS and soothing ingredients including Ectoin, Centella Asiatica Extract, Symcalmin, Portulaca Oleracea Extract and Panthenol.

2. The soothing composition according to claim 1, characterized in that In terms of weight percentage, the contents of LIPOCIRE APELLETS, Ecdoin, Centella asiatica extract, Symcalmin, Portulaca oleracea extract and panthenol are 1-10%, 0.1-1.5%, 0.5-2%, 0.05-1%, 0.05-1%, 0.3-2%, 0.5-5％。 3. A soothing product, characterized in that: The invention comprises a soothing composition as claimed in any one of claims 1 to 2.

4. A composition for preparing a skin care agent that achieves a moisturizing effect by increasing the moisture content of the stratum corneum of the skin, characterized in that: The composition includes LIPOCIRE APELLETS and soothing raw materials including Ectoin, Centella asiatica extract, Symcalmin, Portulaca oleracea extract and Panthenol.

5. The use according to claim 4, characterized in that In terms of weight percentage, the contents of LIPOCIRE APELLETS, ectoine, Centella asiatica extract, Symcalmin, Portulaca oleracea extract and panthenol are 1-10%, 0.1-1.5%, 0.5-2%, 0.05-1%, 0.05-1%, 0.3-2% and 0.5-5%.

6. Use of a composition for preparing an agent for repairing skin barrier by reducing transepidermal water loss rate of the skin, characterized in that: The composition includes LIPOCIRE APELLETS, Ectoin, Centella asiatica extract, Symcalmin, Portulaca oleracea extract, and panthenol.

7. The use according to claim 6, characterized in that In terms of weight percentage, the contents of LIPOCIRE APELLETS, ectoine, Centella asiatica extract, Symcalmin, Portulaca oleracea extract and panthenol are 1-10%, 0.1-1.5%, 0.5-2%, 0.05-1%, 0.05-1%, 0.3-2% and 0.5-5%.

8. A composition for preparing an agent for relieving skin redness by reducing the a* value of skin color, characterized in that: The composition includes LIPOCIRE APELLETS, Ectoin, Centella asiatica extract, Symcalmin, Portulaca oleracea extract, and panthenol.

9. The use according to claim 8, characterized in that In terms of weight percentage, the contents of LIPOCIRE APELLETS, ectoine, Centella asiatica extract, Symcalmin, Portulaca oleracea extract and panthenol are 1-10%, 0.1-1.5%, 0.5-2%, 0.05-1%, 0.05-1%, 0.3-2% and 0.5-5%.

10. Use of LIPOCIRE A PELLETS for preparing a soothing composition for improving the moisturizing, repairing and soothing effects of soothing raw materials, characterized in that: The soothing raw materials include ectoine, Centella asiatica extract, Symcalmin, Portulaca oleracea extract and panthenol, and the soothing composition includes LIPOCIRE A PELLETS, ectoine, Centella asiatica extract, Symcalmin, Portulaca oleracea extract and panthenol.

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