Condensation reaction kettle for pharmacy and fine chemical engineering

Abstract

The invention relates to the technical field of reaction kettles, and discloses a condensation reaction kettle for pharmacy and fine chemical engineering, the condensation reaction kettle comprises a barrel, a motor arranged above the barrel and a stirring shaft connected with the motor, an outer coil pipe with the cross section of a semi-ring structure is spirally arranged outside the barrel in the circumferential direction, and the outer coil pipe is combined with the outer wall of the barrel through a C-shaped opening; an outer coil medium inlet is formed above the outer coil, and an outer coil medium outlet is formed below the outer coil; a jacket is arranged at the bottom of the barrel, a jacket medium outlet is formed below the jacket, a jacket medium inlet is formed above the jacket, and the outer coil medium outlet is communicated with the jacket medium inlet; an inner coil pipe is spirally arranged at the position, close to the inner wall face, in the barrel, and an inner coil pipe medium inlet is formed in the top of the barrel; an inner coil medium outlet is formed in the bottom of the barrel; and the inner coil pipe is fixed on the inner wall of the cylinder body through a fixing device. The device is simple in structure, high in flexibility, capable of rapidly adjusting the temperature and beneficial to uniform distribution of the temperature.

Description

Technical Field

[0001] The present invention relates to the technical field of reaction kettles, and specifically, to a condensation reaction kettle for pharmaceutical and fine chemical industries. Background Art

[0002] Condensation reaction kettles are widely used in technical fields such as polymer material synthesis, pharmaceutical and fine chemical industries, spices and dyes, and biomass conversion. They need to heat the reacting substances at a specific temperature according to process requirements. Therefore, heating structures are provided on the condensation reaction kettles.

[0003] For the pharmaceutical and fine chemical industries, the substances undergoing condensation reactions are sensitive to temperature, so there are high technical requirements for the heating structures of condensation reaction kettles.

[0004] Currently, condensation reaction kettles for pharmaceutical and fine chemical industries usually use jacket structures or heating coil structures for heating. Their heating structure types are single, and it is rather difficult and inflexible to operate when adjusting the heating of the condensation reaction substances, directly affecting the processing efficiency and quality.

[0005] It is found through retrieval that a condensation reaction kettle applicable to the production of pharmaceutical intermediates is disclosed in the prior art. Please refer to the technology with the name of "A Condensation Reaction Kettle", publication number CN219291370U, and publication date July 4, 2023, disclosed in Chinese patent literature. In this technology, by adjusting the supply amount of the heating medium according to the material quantity, temperature control is achieved while reducing energy consumption. However, in the actual production process, when the material quantity is small, using jacket heating will cause uneven temperature distribution inside the reaction kettle, leading to the formation of material fatigue and cracks, thus shortening the service life of the reaction kettle, increasing the maintenance cost. At the same time, the way of jacket heating makes the temperature change slowly, resulting in low production efficiency.

[0006] There is also a condensation reaction kettle applicable to the synthesis of 2-hydroxy chalcone disclosed in the prior art. Please refer to the technology with the name of "Condensation Reaction Kettle for Synthesizing 2-Hydroxy Chalcone", publication number CN208427038U, and publication date January 25, 2019, disclosed in Chinese patent literature. In this technology, by coiling an upper coil and a lower coil on the stirring shaft and connecting them to the jacket outside the kettle body, precise control and uniform distribution of the temperature of the materials inside the kettle are achieved. However, in the actual use process, since the upper coil and the lower coil are coiled on the stirring shaft and connected to the jacket at the same time, such a structure makes the disassembly and assembly process complicated and time-consuming, increasing the difficulty of maintenance and cleaning work, resulting in low production efficiency.

[0007] The prior art also discloses a reaction kettle applicable to condensation reactions. Please refer to the technology with the title of "A Condensation Reaction Kettle with Continuous Feeding" disclosed in the Chinese patent literature, with the publication number CN211586559U and the publication date of September 29, 2020. In this technology, by arranging a heating layer in the reaction kettle and heating coils in the heating layer, the material is heated through the heating coils, achieving effective control of the temperature inside the reaction kettle. However, in the actual production process, heating by the heating coils will cause uneven temperature distribution inside the reaction kettle, leading to the formation of material fatigue and cracks, thereby reducing the service life of the reaction kettle and increasing the maintenance cost. Summary of the Invention

[0008] The technical objective of the present invention is to provide a condensation reaction kettle for pharmaceutical and fine chemical industries, which has a simple structure, high flexibility, can quickly adjust the temperature, and is conducive to achieving uniform temperature distribution, aiming at the deficiencies of the above prior art.

[0009] The technical solution adopted by the present invention is as follows: A condensation reaction kettle for pharmaceutical and fine chemical industries includes a cylinder body, a motor arranged above the cylinder body, and a stirring shaft connected to the motor. The stirring shaft is rotatably arranged inside the cylinder body. The top of the cylinder body is provided with a feed inlet, and the bottom of the cylinder body is provided with a discharge outlet; An outer coil pipe with a semi-circular cross-section is spirally arranged along the circumference outside the cylinder body. The outer coil pipe is combined with the outer wall of the cylinder body with a C-shaped opening. An outer coil pipe medium inlet is arranged above the outer coil pipe, and an outer coil pipe medium outlet is arranged below; A jacket is arranged at the bottom of the cylinder body. A jacket medium outlet is arranged below the jacket, and a jacket medium inlet is arranged above. The outer coil pipe medium outlet is communicated with the jacket medium inlet; Inside the cylinder body, an inner coil pipe is spirally arranged near the inner wall surface. An inner coil pipe medium inlet is arranged at the top of the cylinder body; an inner coil pipe medium outlet is arranged at the bottom of the cylinder body; the inner coil pipe is fixed to the inner wall of the cylinder body through a fixing device.

[0010] Through the synergistic effect of the inner coil, outer coil and jacket, the above technical measures can quickly adjust the temperature of the material, thereby improving the reaction efficiency; the inner coil and the jacket are independently arranged, and both the inner coil and the outer coil are provided with separate medium inlets, with a simple structure, and different heat exchange media can be used respectively according to different requirements, effectively improving flexibility; by arranging the inner coil inside the cylinder body and the jacket at the bottom of the cylinder body, uniform temperature distribution can be achieved during the production process, local overheating or overcooling of the reaction kettle can be avoided, which is beneficial to extending the service life of the condensation reaction kettle and enhancing the stability of the condensation reaction kettle; the outer coil is arranged outside the cylinder body, and the outer coil medium outlet of the outer coil is communicated with the jacket medium inlet. On the one hand, it can transfer the heat exchange medium to the jacket; on the other hand, it can effectively reduce the temperature difference between the inside and outside of the cylinder wall, effectively reduce the damage caused by thermal stress caused by the temperature difference, and thus is beneficial to extending the service life.

[0011] Further, the fixing device includes a plurality of fixing frames, and the plurality of fixing frames are evenly distributed on the inner wall of the cylinder body.

[0012] The above technical measures fix the inner coil through the fixing frame, enhance the structural stability, and at the same time prevent the direct contact between the inner coil and the inner wall of the cylinder body, thereby effectively reducing the damage to the inner wall of the cylinder body caused by the too high or too low temperature of the inner coil, which is beneficial to extending the service life.

[0013] Further, along the axial direction of the stirring shaft, a plurality of stirring blades are arranged at intervals.

[0014] The above technical measures can improve the mixing efficiency of the material by arranging a plurality of stirring blades, thereby improving the reaction efficiency.

[0015] Further, a water inlet is provided at the upper end of the cylinder body.

[0016] The above technical measures can ensure that water does not come into direct contact with other materials by separately arranging the water inlet, avoid the risk of cross-contamination, and at the same time can meet different production requirements.

[0017] Further, remote level gauges are provided at the upper end and the bottom of the cylinder body for detecting the height of the liquid inside the cylinder body and sending height data to the terminal; a remote thermometer is provided at the lower end of the cylinder body for detecting the temperature of the liquid inside the cylinder body and sending temperature data to the terminal.

[0018] The above technical measures can transmit the detected level data and temperature data to the terminal device by arranging remote level gauges and remote thermometers, which is convenient for the staff to remotely monitor and improves the convenience and safety.

[0019] Further, a thermometer is provided on the outer coil pipe for detecting the temperature of the medium inside the outer coil pipe; a thermometer is provided at the lower end of the cylinder body for detecting the temperature of the liquid inside the cylinder body; a liquid level gauge is provided at the top of the cylinder body for detecting the height of the liquid inside the cylinder body.

[0020] The above technical measures ensure that the reaction proceeds at the optimal temperature by setting thermometers to detect the temperatures of the medium and the liquid, and can be adjusted in real time according to requirements; by setting a liquid level gauge to detect the height of the liquid inside the cylinder body, it can prevent the liquid from overflowing due to excessive amount, and can also avoid the influence on the production process caused by too little liquid, thus improving the convenience.

[0021] Further, a manhole is provided at the top of the cylinder body, and a sight glass is assembled on the manhole.

[0022] The above technical measures enable the operator to enter the cylinder body by setting a manhole, which is convenient for maintenance and cleaning, thus improving the convenience; by assembling a sight glass on the manhole, the situation inside the cylinder body can be directly observed from the outside.

[0023] Further, a sampling port is provided at the lower end of the cylinder body.

[0024] The above technical measures facilitate the staff to take samples by setting a sampling port, and can timely judge the progress and status of the reaction, thus improving the convenience.

[0025] Further, the outside of the cylinder body is connected with an ear-type support, and a grounding plate is arranged on the ear-type support.

[0026] The above technical measures improve the stability by arranging the grounding plate on the ear-type support, and can effectively avoid the influence on the grounding effect caused by the deformation of the grounding plate during transportation.

[0027] Further, a gas outlet is provided at the top of the cylinder body.

[0028] The above technical measures can effectively manage the gas emission by setting an independent gas outlet, which is convenient for collecting and treating specific gases, reducing environmental pollution and harm to the human body; the gas generated during the production process can be discharged from the gas outlet, which is beneficial to improving the production efficiency and avoiding the safety hazards caused by gas accumulation.

[0029] One or more technical solutions provided by the present invention have at least the following technical effects or advantages: Through the synergistic effect of the inner coil, outer coil and jacket, the present invention can quickly adjust the temperature of the material, thereby improving the reaction efficiency; the inner coil and the jacket are independently arranged, and both the inner coil and the outer coil are provided with separate medium inlets, with a simple structure, and different heat exchange media can be used separately according to different requirements, effectively improving flexibility; by arranging the inner coil inside the cylinder body and the jacket at the bottom of the cylinder body, uniform temperature distribution can be achieved during the production process, local overheating or overcooling of the reaction kettle can be avoided, which is beneficial to extending the service life of the condensation reaction kettle and enhancing the stability of the condensation reaction kettle; the outer coil is arranged outside the cylinder body, and the outer coil medium outlet of the outer coil is connected to the jacket medium inlet. On the one hand, the heat exchange medium can be transferred to the jacket; on the other hand, the temperature difference between the inside and outside of the cylinder wall can be effectively reduced, and the damage caused by thermal stress due to the temperature difference can be effectively reduced, thereby being beneficial to extending the service life. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] The drawings described herein are used to provide a further understanding of the embodiments of the present invention, form a part of the present invention, and do not limit the embodiments of the present invention; Figure 1 is a schematic structural diagram of the present invention; Figure 2 is a top view of the present invention; Wherein, 1 - cylinder body; 2 - motor; 3 - stirring shaft; 4 - feed inlet; 401 - condensate inlet; 402 - carboxyacetonitrile inlet; 403 - aniline inlet; 404 - nitrogen inlet; 5 - discharge outlet; 6 - outer coil; 601 - outer coil medium inlet; 602 - outer coil medium outlet; 7 - jacket; 701 - jacket medium inlet; 702 - jacket medium outlet; 8 - inner coil; 801 - inner coil medium inlet; 802 - inner coil medium outlet; 9 - fixing frame; 10 - stirring blades; 11 - water inlet; 12 - manhole; 13 - sampling port; 14 - backing plate; 15 - lug support; 16 - earthing plate; 17 - connecting pipe; 18 - sight glass; 19 - gas outlet; 20 - spare port. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0031] In order to more clearly understand the above-mentioned objects, features and advantages of the present invention, the present invention will be further described in detail below with reference to the drawings and specific embodiments. It should be noted that, without conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other.

[0032] In the following description, many specific details are set forth in order to fully understand the present invention. However, the present invention can also be implemented in other ways different from those described herein. Therefore, the protection scope of the present invention is not limited by the specific embodiments disclosed below.

[0033] Refer to Figure 1 - Figure 2, this embodiment provides a condensation reactor for pharmaceutical and fine chemical industries, which includes a cylinder body 1, a motor 2 arranged above the cylinder body 1, and a stirring shaft 3 connected to the motor 2. The stirring shaft 3 is rotatably arranged inside the cylinder body 1. The top of the cylinder body 1 is provided with a feed inlet 4, and the bottom of the cylinder body 1 is provided with a discharge outlet 5; Among them, the feed inlet 4 includes a condensate inlet 401, a carboxylacetonitrile inlet 402, an aniline inlet 403, and a nitrogen inlet 404; it can avoid the mixing of materials before adding, reduce the cross-contamination between different materials, improve safety, allow the simultaneous addition of multiple materials, and is beneficial to improving production efficiency.

[0034] Two spare ports 20 are provided at the top of the cylinder body 1 to adapt to different requirements and changes during the production process, which is beneficial to improving flexibility.

[0035] An outer coil 6 with a semi-circular cross-section is spirally arranged along the circumference outside the cylinder body 1. The outer coil 6 is combined with the outer wall of the cylinder body 1 with a C-shaped opening. An outer coil medium inlet 601 is provided above the outer coil 6, and an outer coil medium outlet 602 is provided below; A jacket 7 is provided at the bottom of the cylinder body 1. A jacket medium outlet 702 is provided below the jacket 7, and a jacket medium inlet 701 is provided above. The outer coil medium outlet 602 is communicated with the jacket medium inlet 701; Among them, the outer coil medium outlet 602 is communicated with the jacket medium inlet 701 through a connecting pipe 17.

[0036] Inside the cylinder body 1, an inner coil 8 is spirally arranged near the inner wall surface. An inner coil medium inlet 801 is provided at the top of the cylinder body 1; an inner coil medium outlet 802 is provided at the bottom of the cylinder body 1; the inner coil 8 is fixed to the inner wall of the cylinder body 1 through a fixing device.

[0037] The fixing device includes a plurality of fixing frames 9, and the plurality of fixing frames 9 are evenly distributed on the inner wall of the cylinder body 1.

[0038] Among them, the specific number of the fixing frames 9 is determined according to actual needs, and no specific limitation is made in this embodiment.

[0039] The fixing frame 9 has a plurality of annular structures, and the annular structures are used to fix the inner coil 8 on the fixing frame 9.

[0040] Axially on the stirring shaft 3, a plurality of stirring blades 10 are arranged at intervals.

[0041] Among them, the specific number of the stirring blades 10 is determined according to actual needs, and no specific limitation is made in this embodiment.

[0042] A water inlet 11 is provided at the upper end of the cylinder body 1.

[0043] A remote liquid level gauge is provided at the upper end and the bottom of the cylinder body 1 for detecting the height of the liquid inside the cylinder body 1 and sending the height data to the terminal; a remote thermometer is provided at the lower end of the cylinder body 1 for detecting the temperature of the liquid inside the cylinder body 1 and sending the temperature data to the terminal.

[0044] A thermometer is provided on the outer coil 6 for detecting the temperature of the medium inside the outer coil 6; a thermometer is provided at the lower end of the cylinder body 1 for detecting the temperature of the liquid inside the cylinder body 1; a liquid level gauge is provided at the top of the cylinder body 1 for detecting the height of the liquid inside the cylinder body 1.

[0045] A manhole 12 is provided at the top of the cylinder body 1, and a sight glass 18 is assembled on the manhole 12.

[0046] A sampling port 13 is provided at the lower end of the cylinder body 1.

[0047] The outside of the cylinder body 1 is connected with an ear-type support 15, and a grounding plate 16 is arranged on the ear-type support 15.

[0048] Wherein, a backing plate 14 for strengthening the connection strength is installed between the ear-type support 15 and the cylinder body 1.

[0049] A gas outlet 19 is provided at the top of the cylinder body 1.

[0050] During application, the materials to be reacted are put into the cylinder body 1 through its dedicated feed port 4, the motor 2 is started to drive the stirring shaft 3, thereby driving the stirring blades 10 to stir inside the cylinder body 1. At the same time, heating or cooling media are introduced into the outer coil 6, the inner coil 8 and the jacket 7 through the outer coil medium inlet 601 and the inner coil medium inlet 801, so that the temperature inside the cylinder body 1 meets the temperature conditions required for the reaction. When water injection is required, water is injected through the water inlet 11. During the reaction process, the reaction situation inside the cylinder body 1 is monitored through the remote liquid level gauge, the remote thermometer, the thermometer and the liquid level gauge. At the same time, the operator can view the reaction situation inside the cylinder body 1 through the sight glass 18. Under the specified conditions, the operator takes a sample of the reaction liquid through the sampling port 13 to detect and evaluate the progress and status of the reaction. The gas generated during the production process can be discharged through the gas outlet 19, and the heating or cooling media are discharged through the inner coil medium outlet 802 and the jacket medium outlet 702. After the reaction is completed, the reaction product is discharged through the discharge port 5 at the bottom of the cylinder body 1. If maintenance and cleaning are required, the operator can enter the inside of the cylinder body 1 through the manhole 12 for maintenance and cleaning.

[0051] Although the preferred embodiments of the present invention have been described, those skilled in the art can make additional changes and modifications once they learn the basic creative concept. Therefore, the appended claims are intended to be construed to include the preferred embodiments as well as all changes and modifications falling within the scope of the present invention.

[0052] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalent technologies, the present invention is also intended to include these modifications and variations.

Claims

1. A condensation reactor for pharmaceutical and fine chemical industries, comprising a barrel (1), a motor (2) disposed above the barrel (1), and a stirring shaft (3) connected to the motor (2), wherein the stirring shaft (3) is rotatably disposed inside the barrel (1), a feed inlet (4) is disposed at the top of the barrel (1), and a discharge outlet (5) is disposed at the bottom of the barrel (1); Features: An outer coil (6) having a semi-ring cross-section is spirally arranged on the outside of the cylinder (1) along the circumferential direction, the outer coil (6) being connected to the outer wall of the cylinder (1) via a C-shaped opening, an outer coil medium inlet (601) being arranged above the outer coil (6) and an outer coil medium outlet (602) being arranged below the outer coil (6); A jacket (7) is provided at the bottom of the cylinder (1), a jacket medium outlet (702) is provided below the jacket (7), and a jacket medium inlet (701) is provided above the jacket (7), and the outer coil medium outlet (602) is connected to the jacket medium inlet (701); An inner coil (8) is spirally arranged inside the cylinder (1) at a position close to the inner wall surface; an inner coil medium inlet (801) is arranged at the top of the cylinder (1); an inner coil medium outlet (802) is arranged at the bottom of the cylinder (1); and the inner coil (8) is fixed to the inner wall of the cylinder (1) by a fixing device.

2. The condensation reactor for pharmaceutical and fine chemical industry according to claim 1, characterized in that: The fixing device comprises a plurality of fixing frames (9), and the plurality of fixing frames (9) are evenly distributed on the inner wall of the cylinder (1).

3. The condensation reactor for pharmaceutical and fine chemical industry according to claim 1, characterized in that: A plurality of stirring blades (10) are arranged at intervals in the axial direction of the stirring shaft (3).

4. The condensation reactor for pharmaceutical and fine chemical industry according to claim 1, characterized in that: The upper end of the cylinder (1) is provided with a water inlet (11).

5. The condensation reactor for pharmaceutical and fine chemical industry according to claim 1, characterized in that: The upper end and the bottom of the cylinder (1) are provided with remote liquid level gauges for detecting the height of the liquid inside the cylinder (1) and sending the height data to a terminal; the lower end of the cylinder (1) is provided with a remote thermometer for detecting the temperature of the liquid inside the cylinder (1) and sending the temperature data to a terminal.

6. The condensation reactor for pharmaceutical and fine chemical industry according to claim 1, characterized in that: The outer coil (6) is provided with a thermometer for detecting the temperature of the medium in the outer coil (6); the lower end of the cylinder (1) is provided with a thermometer for detecting the temperature of the liquid inside the cylinder (1); and the top of the cylinder (1) is provided with a liquid level gauge for detecting the height of the liquid inside the cylinder (1).

7. The condensation reactor for pharmaceutical and fine chemical industry according to claim 1, characterized in that: A manhole (12) is provided at the top of the cylinder (1), and a sight glass (18) is mounted on the manhole (12).

8. The condensation reactor for pharmaceutical and fine chemical industry according to claim 1, characterized in that: A sampling port (13) is provided at the lower end of the cylinder (1).

9. The condensation reactor for pharmaceutical and fine chemical industry according to claim 1, characterized in that: The cylinder (1) is externally connected to an ear-type support (15), and a grounding plate (16) is provided on the ear-type support (15).

10. The condensation reactor for pharmaceutical and fine chemical industry according to claim 1, characterized in that: The top of the cylinder (1) is provided with a gas outlet (19).

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