A high-safety supercritical extraction device for pharmaceutical use

Abstract

The application relates to a high-safety supercritical extraction device for pharmacy, which comprises an extraction tank body, an auxiliary shell, a filter screen cover, a partition plate, a flow guide cylinder, a flow guide port, a spiral wheel, a tank cover, a tank body rod and a tank plug, the auxiliary shell is additionally arranged on the extraction tank body, the extraction medium is driven by the spiral wheel to circularly flow between the extraction tank body and the auxiliary shell, the flowing extraction medium is filtered by the filter screen cover, the extraction material is prevented from entering the auxiliary shell, the mixing of the extraction medium and the extraction material is realized by flow washing, the mixing effect of the extraction medium and the extraction material is effectively improved, the mixing mode of the extraction medium and the extraction material is simpler in the technical scheme, the mixing structure of the technical scheme is arranged in the auxiliary shell and does not occupy the central region of the extraction tank body, and the internal extraction material is quickly taken out by pulling out the tank plug, so that the replacement efficiency of the extraction material is effectively improved.

Description

Technical Field

[0001] The present invention relates to a supercritical extraction device, in particular to a high-safety supercritical extraction device for pharmaceutical use applied in the technical field of supercritical extraction. Background Art

[0002] Supercritical extraction is a technique that uses supercritical fluid as an extraction medium to separate the different components in a mixture. A supercritical fluid is a fluid state above its critical temperature and pressure. In this state, the fluid possesses unique solubility and diffusion properties, making it an effective medium in the extraction process. To ensure thorough mixing of the extraction medium and the material being extracted, the extraction tank is equipped with a stirring mechanism. However, this active stirring mechanism can affect the sealing difficulty of the extraction tank and the safety performance of the extraction equipment.

[0003] The specification of Chinese invention patent CN201921156181.1 discloses "A liquid fractionation kettle for supercritical extraction", which drives the stirring shaft to rotate by non-contact electromagnetic stirring. In the overall equipment, only two large positions, between the kettle cover and the kettle body unit and between the stirring shaft sleeve and the kettle cover, need to fully ensure sealing; avoiding the conventional stirring method that leads to poor sealing and safety risks.

[0004] When extracting certain solid materials that are not suitable for crushing pretreatment, it is necessary to keep the fiber structure of natural products unchanged. The extraction equipment needs to be opened for feeding and discharging. The extraction materials are loaded at one time and the supercritical fluid is continuously introduced. The materials in the extraction tank need to be replaced frequently by humans. However, the traditional stirring shaft structure and the magnetic stirring shaft structure in the above patent are both located in the center of the extraction tank, resulting in a relatively complex replacement environment for the extraction materials. The entry and exit of the extraction materials are blocked by the mixing structure, affecting the replacement efficiency of the extraction materials. Summary of the Invention

[0005] In view of the above-mentioned prior art, the technical problem to be solved by the present invention is that the traditional stirring shaft structure and the magnetic stirring shaft structure in the above-mentioned patent are both located in the center of the extraction tank, which makes the replacement environment of the extraction material relatively complex and affects the replacement efficiency of the extraction material.

[0006] To solve the above problems, the application provides a high-safety supercritical extraction equipment for pharmaceutical use, which comprises an extraction tank body, an auxiliary shell body fixedly connected to the top of the extraction tank body, a filter screen cover fixedly connected between the extraction tank body and the auxiliary shell body, an output pipe and an input pipe fixedly connected to the top and bottom of the auxiliary shell body respectively, a partition plate fixedly connected to the middle of the auxiliary shell body, a flow guide cylinder fixedly connected between the partition plate and the input pipe, a flow guide opening provided between the bottom of the flow guide cylinder and the top of the partition plate, a spiral wheel rotatably connected to the inside of the flow guide cylinder, a driving motor fixedly connected to the outside of the auxiliary shell body, and two magnetic suction wheels fixedly connected to the output end of the driving motor and the tail of the spiral wheel respectively.

[0007] A tank cover is clamped to the inside of the tank opening of the extraction tank body, a tank rod is fixedly connected to the inner end of the tank cover, a tank plug is fixedly connected to the bottom end of the tank rod, the tank plug corresponds to the tank bottom of the extraction tank body, and the top of the tank plug is provided in a slope.

[0008] In the high-safety supercritical extraction equipment for pharmaceutical use, the auxiliary shell body is additionally arranged on the extraction tank body, and the extraction medium is circulated between the extraction tank body and the auxiliary shell body by the spiral wheel, so that the extraction medium and the extraction material are mixed, and compared with the traditional stirring and mixing structure, the sealing assembly of the extraction tank body is facilitated, and the safety hazard caused by the poor sealing effect of the extraction tank body is effectively avoided.

[0009] As a further improvement of the application, the tank rod is close to the inner wall of the extraction tank body, and a disturbance rotating wheel is rotatably connected to the outside of the tank rod, the disturbance rotating wheel is provided in a spherical shape, and the flowing extraction medium pushes the disturbance rotating wheel, so that the rotation of the disturbance rotating wheel is further utilized to improve the mixing effect of the extraction medium and the extraction material.

[0010] As a further improvement of the application, a plug plate is fixedly connected between the disturbance rotating wheel and the top end of the slope of the tank plug, the plug plate corresponds to the same plane of the partition plate, the plug plate extends the partition of the partition plate inside the extraction tank body, effectively prevents the extraction medium just discharged from the auxiliary shell body from returning to the auxiliary shell body quickly, and effectively improves the contact time of the extraction medium and the extraction material.

[0011] As a further improvement of the application, a concentration window is provided in the bottom of the plug plate, the concentration window corresponds to the bottom of the disturbance rotating wheel, the extraction medium flows through the concentration window, so that the extraction medium concentrates and impacts the disturbance rotating wheel, and the rotation effect of the disturbance rotating wheel is effectively improved.

[0012] As another improvement of the present application, a storage groove is provided at the top of the gate plate, and a sealing tape is placed inside the storage groove. The sealing tape is in close contact with the bottom end of the partition plate, and a sealing rubber pad is fixedly connected to the top contact surface of the sealing tape. The sealing tape is used in combination with the sealing rubber pad to effectively improve the contact effect with the partition plate, thereby effectively improving the effect of blocking the extraction medium.

[0013] As another improved supplement to the present application, the interior of the sealing belt is hollow and filled with inert gas, so that the sealing belt rises due to buoyancy and sinks back into the storage tank after the extraction medium is emptied.

[0014] As another improved supplement to the present application, both ends of the upper opening of the storage tank are fixedly connected with an extended scraper, which corresponds to the lower surface of the filter cover. The extended scraper is used to clean the lower surface of the filter cover and prevent the extracted material from falling into the storage tank.

[0015] As another improved supplement to the present application, a scraping brush is fixedly connected to the contact end of the extended scraper frame and the filter cover. The scraping brush is made of wear-resistant rubber material. The scraping brush is used to effectively improve the cleaning effect of the extended scraper frame on the lower surface of the filter cover.

[0016] As another improvement of the present application, a blocking scoop is fixedly connected to the bottom end of the inclined surface of the tank plug, and the blocking scoop is arranged in an arc shape corresponding to the filter cover. The blocking scoop is utilized to block the extraction material, thereby effectively improving the collection of the extraction material on the inclined surface of the tank plug, and at the same time effectively preventing the extraction material from contacting the lower surface of the filter cover again when the tank plug is taken out.

[0017] To sum up, the present invention adds an auxiliary shell to the extraction tank body, and uses a partition plate to divide the internal space of the auxiliary shell into two areas, corresponding to the outflow area and the reflux area of ​​the extraction medium. Subsequently, the extraction medium is driven by a spiral wheel to circulate between the extraction tank body and the auxiliary shell, and the filter cover is used to filter the flowing extraction medium to prevent the extraction material from entering the auxiliary shell. The flow of the extraction medium is used to flush the extraction material to achieve mixing with the extraction material, thereby effectively improving the mixing effect of the extraction medium and the extraction material. Compared with the traditional stirring and mixing structure, the mixing structure of the extraction medium and the extraction material in this technical solution is located in the auxiliary shell and does not occupy the central area of ​​the extraction tank body, providing a smooth material inlet and outlet environment for the extraction tank body, and the internal extraction material is quickly brought out by pulling out the plug in the tank, thereby effectively improving the replacement efficiency of the extraction material. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a three-dimensional structural diagram of the first embodiment of the present application;

[0019] Figure 2This is a three-dimensional structural diagram of the extraction tank and the auxiliary housing according to the first embodiment of the present application;

[0020] Figure 3 This is a diagram illustrating the circulation of the extraction medium according to the first embodiment of the present application;

[0021] Figure 4 This is a sectional perspective structural diagram of a partition plate according to the first embodiment of the present application;

[0022] Figure 5 This is a three-dimensional structural diagram of the spiral wheel and the driving motor in the first embodiment of the present application;

[0023] Figure 6 This is a three-dimensional structural diagram of a can cover and a can plug according to the first embodiment of the present application;

[0024] Figure 7 This is a three-dimensional structural diagram of a tank plug according to a second embodiment of the present application;

[0025] Figure 8 This is a three-dimensional structural diagram of a door panel according to a second embodiment of the present application;

[0026] Figure 9 This is a cross-sectional view of the receiving groove according to the second embodiment of the present application.

[0027] Description of the numbers in the figure:

[0028] 1. Extraction tank body; 101. Auxiliary shell; 102. Filter cover; 103. Output pipe; 104. Input pipe; 105. Partition plate; 106. Drainage tube; 107. Drainage port; 108. Spiral wheel; 109. Drive motor; 110. Magnetic wheel; 2. Tank cover; 201. Tank rod; 202. Tank plug; 203. Disturbance wheel; 204. Plug door plate; 205. Centralizing window; 3. Storage slot; 301. Sealing tape; 302. Sealing pad; 303. Extended scraper; 304. Scraping brush; 305. Blocking plate. DETAILED DESCRIPTION

[0029] Two implementation modes of the present application are described in detail below with reference to the accompanying drawings.

[0030] The first implementation method:

[0031] Figures 1 to 5The figure shows a high-safety supercritical extraction equipment for pharmaceutical use, comprising an extraction tank body 1, the top of the extraction tank body 1 is fixedly connected to an auxiliary shell 101, and a filter cover 102 is fixedly connected between the extraction tank body 1 and the auxiliary shell 101, the top and bottom of the auxiliary shell 101 are respectively fixedly connected to an output pipe 103 and an input pipe 104, and a partition plate 105 is fixedly connected to the middle of the auxiliary shell 101, a drainage tube 106 is fixedly connected between the partition plate 105 and the input pipe 104, the lower opening of the drainage tube 106 faces the filter cover 102, and a drainage port 107 is opened between the drainage tube 106 and the top of the partition plate 105, the interior of the drainage tube 106 is rotatably connected to a spiral wheel 108, the outside of the auxiliary shell 101 is fixedly connected to a drive motor 109, the output end of the drive motor 109 and the tail of the spiral wheel 108 are fixedly connected to a magnetic attraction wheel 110, and the two magnetic attraction wheels 110 are arranged to attract each other by magnetic force;

[0032] During supercritical extraction of medicinal materials, the auxiliary housing 101 is divided into two areas according to the partition plate 105, corresponding to the outflow area and the reflux area of ​​the extraction medium. The input pipe 104 feeds the extraction medium into the outflow area, and the output pipe 103 discharges the extraction medium from the reflux area. When the input and output of the extraction medium stop, the magnetic attraction of the two magnetic wheels 110 realizes the non-contact transmission connection between the drive motor 109 and the spiral wheel 108. The spiral wheel 108 drives the extraction medium in the drainage tube 106 to fill the bottom of the extraction tank body 1, thereby realizing the extraction medium flowing along the inclined surface of the tank plug 202. , and then rises along the extraction tank body 1 and mixes with the extraction material in the extraction tank body 1. Finally, the extraction material passes through the filter cover 102 again and enters the reflux area. The extraction material in the reflux area enters the drainage tube 106 again through the drainage port 107, realizing the circulation of the extraction medium between the extraction tank body 1 and the auxiliary shell 101, extending the mixing time of the extraction material and the extraction medium, and effectively improving the mixing effect of the extraction medium and the extraction material, thereby effectively improving the extraction quality, while maintaining a relatively empty and unobstructed environment in the extraction tank body 1, facilitating the replacement operation of the extraction material in the extraction tank body 1.

[0033] Figure 1 and Figure 3 As shown, a tank cover 2 is clamped inside the mouth of the extraction tank body 1, and the inner end of the tank cover 2 is fixedly connected to a tank rod 201. The bottom end of the tank rod 201 is fixedly connected to a tank plug 202. The tank plug 202 corresponds to the bottom of the extraction tank body 1, and the top of the tank plug 202 is arranged in an inclined surface. The inclined surface of the tank plug 202 corresponds to the outlet of the drainage tube 106.

[0034] Before the extraction work is carried out, the drug extraction material is inserted into the extraction tank body 1 together with the tank plug 202, ensuring that the tank plug 202 is at the bottom of the extraction tank body 1 and the extraction material is at the top of the tank plug 202. When replacing the extraction material in the extraction tank body 1, the tank cover 2 is removed, and the tank plug 202 is pulled outward through the tank cover 2. The tank plug 202 is used to push the extraction material in the extraction tank body 1, so that the tank plug 202 brings the extraction material out of the extraction tank body 1, effectively improving the replacement efficiency of the extraction material.

[0035] Figures 3 to 6 As shown, the tank rod 201 is close to the inner wall of the extraction tank body 1, and the outer part of the tank rod 201 is rotatably connected to the disturbance wheel 203, which is spherical. The flowing extraction medium pushes the disturbance wheel 203, so that the rotation of the disturbance wheel 203 further improves the mixing effect of the extraction medium and the extraction material. A plug door plate 204 is fixedly connected between the disturbance wheel 203 and the top of the inclined surface of the tank plug 202. The plug door plate 204 corresponds to the same plane as the partition plate 105, and the plug door plate 204 is used to extend the partition plate 105. The partition 105 separates the interior of the extraction tank 1, effectively preventing the extraction medium just discharged from the auxiliary housing 101 from quickly returning to the auxiliary housing 101, thereby effectively increasing the contact time between the extraction medium and the extraction material. A focusing window 205 is provided at the bottom of the stopper plate 204. The focusing window 205 corresponds to the bottom of the disturbance wheel 203. The extraction medium flows through the focusing window 205 in a concentrated manner, thereby achieving a concentrated impact of the extraction medium on the disturbance wheel 203, thereby effectively improving the rotation effect of the disturbance wheel 203.

[0036] By combining the gate plate 204 with the partition plate 105, the blocking effect of the partition plate 105 on the extraction medium is extended to the inside of the partition plate 105, thereby effectively increasing the contact time between the extraction medium and the extraction material. The extraction medium blocked by the gate plate 204 descends and finally passes through the concentration window 205 at the bottom of the gate plate 204, so that the flowing extraction medium can more concentratedly push the disturbance wheel 203 to rotate, thereby achieving the mixing effect of the extraction medium and the extraction material by utilizing the rotation of the disturbance wheel 203. The gate plate 204 extends the partition plate 105 to separate the interior of the extraction tank body 1, effectively preventing the extraction medium just discharged from the auxiliary shell 101 from quickly returning to the auxiliary shell 101, thereby effectively improving the circulation flow effect of the extraction medium, and by opening the concentration window 205 at the bottom of the gate plate 204, the concentration of the extraction medium is facilitated, thereby effectively increasing the impact effect of the extraction medium on the disturbance wheel 203, thereby effectively improving the rotation effect of the disturbance wheel 203.

[0037] The second implementation method:

[0038] Compared with the first embodiment, this embodiment mainly adds a sealing belt 301. The specific new structure is as follows, and the remaining structures are consistent with the first embodiment.

[0039] Figures 7 and 8 As shown, a receiving groove 3 is formed at the top of the plug door plate 204, and a sealing tape 301 is placed inside the receiving groove 3. The sealing tape 301 is in close contact with the bottom end of the partition plate 105, and a sealing rubber gasket 302 is fixedly connected to the top contact surface of the sealing tape 301. The sealing tape 301 and the sealing rubber gasket 302 are used to effectively improve the contact effect with the partition plate 105, thereby effectively improving the effect of blocking the extraction medium. The interior of the sealing tape 301 is hollow and filled with inert gas, so that the sealing tape 301 rises due to buoyancy, and after the extraction medium is emptied, the sealing tape 301 sinks back into the receiving groove 3;

[0040] After the extraction tank body 1 is filled with the extraction medium, the sealing tape 301 in the receiving groove 3 rises due to its own buoyancy, and cooperates with the sealing gasket 302 to effectively improve the contact effect with the partition plate 105, thereby effectively improving the blocking and sealing effect of the top of the plug plate 204 on the extraction medium, and effectively improving the drainage capacity of the extraction medium. The hollow sealing tape 301 effectively improves its own buoyancy, and even if the filled inert gas leaks, it can effectively avoid contamination of the extraction material.

[0041] Figures 7 to 9 As shown, both ends of the upper opening of the storage tank 3 are fixedly connected with an extended scraper 303, which corresponds to the lower surface of the filter cover 102. The extended scraper 303 is used to clean the lower surface of the filter cover 102 and prevent the extracted material from falling into the storage tank 3. The contact end of the extended scraper 303 and the filter cover 102 is fixedly connected with a scraping brush 304. The scraping brush 304 is made of wear-resistant rubber material. 4. The extended scraper 303 effectively improves the cleaning effect of the lower surface of the filter cover 102. The bottom end of the inclined surface of the tank plug 202 is fixedly connected to a blocking plate 305. The blocking plate 305 is arranged in an arc shape corresponding to the filter cover 102. The blocking plate 305 blocks the extraction material, effectively improving the collection of the extraction material on the inclined surface of the tank plug 202, and effectively preventing the extraction material from contacting the lower surface of the filter cover 102 again when the tank plug 202 is removed;

[0042] When replacing the extraction material in the extraction tank body 1, the extraction medium in the extraction tank body 1 is first emptied to restore the internal pressure of the extraction tank body 1 to normal pressure, and then the tank cover 2 is opened and the tank plug 202 is pulled out. During the process of pulling out the tank plug 202, the extended scraper 303 on the plug door plate 204 is used to clean the lower surface of the filter cover 102. The extended scraper 303 is in a state of extending outward from the receiving tank 3, effectively preventing the extraction material from entering the receiving tank 3, and the sealing belt 301 no longer rises due to buoyancy. At this time, The sealing tape 301 sinks into the receiving groove 3, thereby effectively separating the gate plate 204 from the partition plate 105 and the filter cover 102, thereby effectively avoiding friction between the sealing tape 301 and the filter cover 102, thereby increasing the service life of the sealing tape 301 and facilitating the movement of the gate plate 204. Finally, the extracted material is supported by the inclined surface of the tank plug 202 and taken out of the tank plug 202, and the blocking plate 305 prevents the extracted material from contacting the filter cover 102 again along the inclined surface of the tank plug 202, thereby effectively improving the extraction effect of the extracted material.

[0043] In view of current actual needs, the protection scope of the above-mentioned implementation mode adopted in this application is not limited to this. Various changes made within the knowledge scope of technical personnel in this field without departing from the concept of this application still fall within the protection scope of the present invention.

Claims

1. A highly safe supercritical extraction device for pharmaceutical use, characterized by: The invention comprises an extraction tank body (1), wherein the top of the extraction tank body (1) is fixedly connected to an auxiliary shell (101), and a filter cover (102) is fixedly connected between the extraction tank body (1) and the auxiliary shell (101), the top and bottom of the auxiliary shell (101) are respectively fixedly connected to an output pipe (103) and an input pipe (104), and a partition plate (105) is fixedly connected to the middle of the auxiliary shell (101), and a drainage tube (106) is fixedly connected between the partition plate (105) and the input pipe (104). The lower opening of the drainage tube (106) faces the filter cover (102), and a drainage port (107) is provided between the drainage tube (106) and the top of the partition plate (105). The interior of the drainage tube (106) is rotatably connected to a spiral wheel (108), and the exterior of the auxiliary housing (101) is fixedly connected to a drive motor (109). The output end of the drive motor (109) and the tail of the spiral wheel (108) are both fixedly connected to magnetic wheels (110), and the two magnetic wheels (110) are arranged to attract each other magnetically. A tank cover (2) is clamped inside the tank mouth of the extraction tank body (1), the inner end of the tank cover (2) is fixedly connected to a tank body rod (201), and the bottom end of the tank body rod (201) is fixedly connected to a tank plug (202), the tank plug (202) corresponds to the tank bottom of the extraction tank body (1), and the top of the tank plug (202) is arranged in an inclined surface, and the inclined surface of the tank plug (202) corresponds to the outlet of the drainage tube (106); The tank rod (201) is close to the inner wall of the extraction tank (1), and the outer portion of the tank rod (201) is rotatably connected to a disturbance wheel (203), wherein the disturbance wheel (203) is spherically arranged; A plug door plate (204) is fixedly connected between the disturbance wheel (203) and the top of the inclined surface of the tank plug (202), and the plug door plate (204) corresponds to the partition plate (105) in the same plane. A centralizing window (205) is provided at the bottom of the gate plate (204), and the centralizing window (205) corresponds to the bottom of the disturbance wheel (203).

2. A highly safe supercritical extraction equipment for pharmaceutical use according to claim 1, characterized in that: A receiving groove (3) is provided at the top of the gate plate (204), a sealing tape (301) is placed inside the receiving groove (3), the sealing tape (301) is in close contact with the bottom end of the partition plate (105), and a sealing rubber pad (302) is fixedly connected to the top contact surface of the sealing tape (301).

3. A highly safe supercritical extraction device for pharmaceutical use according to claim 2, characterized in that: The interior of the sealing tape (301) is hollow, and the interior of the sealing tape (301) is filled with inert gas.

4. A highly safe supercritical extraction device for pharmaceutical use according to claim 2, characterized in that: Both ends of the upper opening of the storage groove (3) are fixedly connected to an outward-extending scraper (303), and the outward-extending scraper (303) corresponds to the lower surface of the filter cover (102).

5. The high-safety supercritical extraction equipment for pharmaceutical use according to claim 4, characterized in that: A scraping brush (304) is fixedly connected to the contact end of the extended scraper frame (303) and the filter screen cover (102), and the scraping brush (304) is made of a wear-resistant rubber material.

6. The high-safety supercritical extraction equipment for pharmaceutical use according to claim 1, characterized in that: The bottom end of the inclined surface of the tank plug (202) is fixedly connected to a blocking plate (305), and the blocking plate (305) is arranged in an arc shape corresponding to the filter cover (102).

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