Human body explosive shock wave induced craniocerebral injury dose-effect relationship evaluation device, equipment and medium

Abstract

The invention provides a device and equipment for evaluating the dose-effect relationship of craniocerebral injury caused by human body explosive shock waves and a medium, and relates to the technical field of craniocerebral injury dose-effect relationship evaluation.The method comprises the steps that firstly, the scale law relationship of explosive shock wave attenuation coefficients of different species is established, and the incidence pressure peak values of the forehead of the human body corresponding to different incidence overpressure duration time are calculated; and then establishing a human body craniocerebral explosion injury 50% survival curve, and evaluating the craniocerebral injury dose-effect relationship of the person to be evaluated based on the curve. According to the evaluation device, by combining experimental animals with different weights and skull thicknesses, high-precision physical head models and other outfield actual explosion experiments, the dose-effect relationship of the craniocerebral injury of the experimental animals is transited to people, the dose-effect relationship of the craniocerebral injury of the human body is established, a craniocerebral injury evaluation system of the human body explosive shock waves is formed, and the complex structure of the craniocerebral of the human body is considered; and the dose-effect relationship of the animal is filtered into the human body, so that the dose-effect relationship of craniocerebral injury when the human body is subjected to explosion impact can be evaluated more accurately.

Description

Technical Field

[0001] This application relates to the technical field of evaluating the dose - effect relationship of craniocerebral injury, and particularly to an evaluation device, equipment, and medium for the dose - effect relationship of craniocerebral injury caused by human body explosion shock waves. Background Art

[0002] In modern warfare and specific industrial environments, the incidence of traumatic brain injury (TBI) has increased significantly. In particular, traumatic brain injury (TBI) caused by explosion shock waves has become the "characteristic trauma of modern warfare". This type of TBI not only causes severe physical and cognitive dysfunction but also may trigger post - traumatic stress disorder (PTSD), leading to social problems such as depression, anxiety, suicide, and violence. Therefore, accurately evaluating the dose - effect relationship between the peak overpressure of the explosion shock wave load and the intracranial pressure of the human body is of great significance for injury assessment and shock wave protection.

[0003] However, due to ethical restrictions, it has been difficult to accurately measure and evaluate the dose - effect relationship between human intracranial pressure and the peak overpressure of the explosion wave through experiments. Currently, the dose - effect relationship of craniocerebral injury caused by human body explosion shock waves is mainly obtained through mass scaling methods. Specifically, by conducting explosion experiments in animal models such as rats, goats, or pigs, measuring the dose - effect relationship between intracranial pressure and the peak overpressure of the explosion shock wave, and then scaling according to the mass ratio between the human body and the animal. However, the human cranium is a complex three - dimensional structure, and the simple mass scaling law is difficult to accurately evaluate the dose - effect relationship of the human body. In addition, there are contradictions between the dose - effect relationships obtained by scaling different animal models, further weakening the credibility of the dose - effect relationship of the human body obtained by the current mass scaling law. Summary of the Invention

[0004] This application provides an evaluation device, equipment, and medium for the dose - effect relationship of craniocerebral injury caused by human body explosion shock waves to solve the problem that the existing evaluation methods for the dose - effect relationship of craniocerebral injury caused by human body explosion shock waves are difficult to accurately evaluate the dose - effect relationship of the human body.

[0005] In a first aspect, this application proposes an evaluation device for the dose - effect relationship of craniocerebral injury caused by human body explosion shock waves, and the device includes: A relationship establishment module for establishing a scale - law relationship of the explosion shock wave attenuation coefficient of different species based on the skull thickness of different animals; A calculation module for calculating the peak incident pressure of the human forehead corresponding to different incident overpressure durations based on the scale - law relationship of the explosion shock wave attenuation coefficient of different species and the principle of consistency between the interaction mechanism of the human head frontal impact point and the peak intracranial pressure; A survival curve establishment module, configured to establish a 50% survival curve for human craniocerebral blast injury based on the peak incident pressure on the human forehead corresponding to different incident overpressure durations; An evaluation module, configured to obtain the peak blast overpressure and the incident overpressure duration in the area where the person to be evaluated is located, and evaluate the dose-effect relationship of craniocerebral injury of the person to be evaluated in combination with the 50% survival curve of human craniocerebral blast injury.

[0006] Optionally, the scaling law relationship of the blast wave attenuation coefficients of different species established in the relationship establishment module is as follows: , where, represents the skull thickness of different animals, and η represents the attenuation coefficient.

[0007] Optionally, the calculation module includes: A determination sub-module, configured to determine the blast wave reflection coefficient of different animal heads based on the incident angle of the blast wave at the forehead of different animals; An acquisition sub-module, configured to acquire the transmission coefficient at the forehead of animals with different skull thicknesses; A first calculation sub-module, configured to calculate the peak value of the global maximum intracranial pressure of different animals based on the blast wave reflection coefficient and the transmission coefficient at the forehead of different animal heads, and the impact pressure; A second calculation sub-module, configured to calculate the peak incident pressure on the human forehead corresponding to different incident overpressure durations based on the principle that the peak value of the injury pressure of the human head is equal to the peak value of the global maximum intracranial pressure of different animals, and the function of the change of the intracranial pressure peak value with time among different animals.

[0008] Optionally, the acquisition sub-module includes: An acquisition unit, configured to acquire the intracranial pressure and the surface pressure of animals with different skull thicknesses; A calculation unit, configured to calculate the transmission coefficient at the forehead based on the intracranial pressure and the surface pressure of animals with different skull thicknesses.

[0009] Optionally, the formula for calculating the peak value of the global maximum intracranial pressure of different animals in the first calculation sub-module is as follows: , where, represents the incident pressure of the shock wave, represents the reflection coefficient, α represents the incident angle of the shock wave, represents the skull thickness, represents the transmission coefficient at the forehead corresponding to animals with different skull thicknesses.

[0010] Optionally, the second calculation sub-module includes: A calculation unit, configured to calculate the explosion shock wave attenuation coefficient and the transmission coefficient at the human forehead based on the scaling law relationship of the explosion shock wave attenuation coefficients of different species and the skull thickness at the human forehead.

[0011] Optionally, the principle that the peak value of the head injury pressure in the second calculation sub-module is equal to the peak value of the global maximum intracranial pressure of the heads of different animals is as follows: , wherein, represents the atmospheric pressure, represents the impact pressure on the human head, represents the transmission coefficient of the human forehead, represents the skull thickness of the human forehead, represents the impact pressure on the heads of different animals, represents the reflection coefficient, represents the incident angle of the shock wave of different animals, represents the transmission coefficient of the foreheads of different animals, represents the skull thickness of different animals.

[0012] Optionally, the evaluation module includes: A first evaluation sub-module, configured to evaluate that the dose-effect relationship of the head injury of the person to be evaluated is that the death probability is less than 50% when the point formed by the peak value of the overpressure and the incident overpressure duration in the area where the person to be evaluated is located is below the 50% survival curve of human craniocerebral blast injury; A second evaluation sub-module, configured to evaluate that the dose-effect relationship of the head injury of the person to be evaluated is that the death probability is greater than 50% when the point formed by the peak value of the overpressure and the incident overpressure duration in the area where the person to be evaluated is located is above the 50% survival curve of human craniocerebral blast injury.

[0013] In a second aspect, the present application provides an electronic device, including a memory, a processor, and a computer program stored on the memory, where the processor executes the computer program to implement the functions of the evaluation device for the dose-effect relationship of human craniocerebral injury caused by explosion shock waves according to any one of the first aspects.

[0014] In a third aspect, the present application provides a computer-readable storage medium, on which a computer program / instructions are stored, and when the computer program / instructions are executed by a processor, the functions of the evaluation device for the dose-effect relationship of human craniocerebral injury caused by explosion shock waves according to any one of the first aspects are implemented.

[0015] The present application has the following advantages: The present application provides an evaluation device, equipment and medium for the dose-effect relationship of human craniocerebral injury caused by explosion shock waves. First, through a relationship establishment module, based on the skull thicknesses of different animals, a scaling law relationship of the explosion shock wave attenuation coefficients of different species is established. Then, through a calculation module, based on the scaling law relationship of the explosion shock wave attenuation coefficients of different species and the principle of consistency between the interaction mechanism at the impact point of the human head forehead and the peak intracranial pressure, the peak incident pressure of the human forehead corresponding to different incident overpressure durations is calculated. Further, through a survival curve establishment module, based on the peak incident pressure of the human forehead corresponding to different incident overpressure durations, a 50% survival curve of human craniocerebral blast injury is established. Finally, through an evaluation module, the peak explosion overpressure and the incident overpressure duration in the area where the person to be evaluated is located are obtained, and in combination with the 50% survival curve of human craniocerebral blast injury, the dose-effect relationship of the craniocerebral injury of the person to be evaluated is evaluated. By combining field explosion experiments such as experimental animals with different weights and skull thicknesses and a high-precision physical head model, this evaluation device clarifies the scaling law relationship between animals and humans, transitions the dose-effect relationship of experimental animal craniocerebral injury to humans, establishes the dose-effect relationship of human craniocerebral injury, forms a human explosion shock wave craniocerebral injury evaluation system, takes into account the complex structure of the human cranium, filters the dose-effect relationship of animals to humans, and can be more accurately used to evaluate the dose-effect relationship of human craniocerebral injury when subjected to explosion shock. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for the description of the embodiments of the present application will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0017] Figure 1 is a schematic diagram of the functional modules of the evaluation device for the dose-effect relationship of human craniocerebral injury caused by explosion shock waves provided by the embodiments of the present application; Figure 2 is a schematic diagram of the propagation direction and impact point of the explosion wave applied to the human forehead provided by the embodiments of the present application; Figure 3 is a semi-empirical result of oblique reflection under a peak incident pressure of 200 kPa provided by the embodiments of the present application; Figure 4 is the incident angle of the explosion wave at the forehead of different animals provided by the embodiments of the present application; Figure 5 is the scaling law relationship of the explosion shock wave attenuation coefficients of different animals provided by the embodiments of the present application; Figure 6It is the dose-effect relationship between intracranial pressure and surface pressure at the forehead of 15 kg and 30 kg Bama mini-pigs provided by the embodiments of the present application; Figure 7 It is the forehead transmission coefficient of different animals provided by the embodiments of the present application; Figure 8 It is the 50% survival curve of human craniocerebral blast injury provided by the embodiments of the present application; Figure 9 It is a schematic diagram of an electronic device provided by the embodiments of the present application. Detailed implementation manners

[0018] Next, the technical solutions in the embodiments of the present application will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present application.

[0019] Currently, the dose-effect relationship of human blast wave-induced craniocerebral injury is mainly obtained through mass scaling, that is, the dose-effect relationship between intracranial pressure and the peak overpressure of blast wave in animals such as rats, goats or pigs is obtained through explosion experiments, and then the dose-effect relationship is scaled to humans according to the mass ratio between humans and animals. However, this method does not consider that the human cranium is a complex three-dimensional structure, and the simple mass scaling law is difficult to accurately evaluate the dose-effect relationship of humans; and the dose-effect relationships obtained by scaling according to different animals are contradictory to each other.

[0020] In addition, although the existing method has a multi-probe monitoring system for directly measuring the intracranial pressure of animal craniums, which can sense the pressure values at different parts of the cranium, due to ethical restrictions, this measurement and detection method cannot be extended to measure the intracranial pressure of humans.

[0021] Based on this, the present invention proposes an evaluation method for the dose-effect relationship of human blast wave-induced craniocerebral injury based on the scale law between species. This method clarifies the scale law relationship between animals and humans through field explosion experiments such as combining 5 experimental animals with different weights and skull thicknesses and a high-precision physical head model, transitions the dose-effect relationship of animal craniocerebral injury to humans, establishes the dose-effect relationship of human craniocerebral injury, and forms an evaluation system for human blast wave-induced craniocerebral injury.

[0022] In the first aspect, the embodiments of the present application propose an evaluation device for the dose-effect relationship of human blast wave-induced craniocerebral injury. Refer to Figure 1 , Figure 1 It is a schematic diagram of the functional modules of an evaluation device for the dose-effect relationship of human blast wave-induced craniocerebral injury proposed by the embodiments of the present application. The device includes: The relationship establishment module 101 is used to establish a scaling law relationship of the blast wave attenuation coefficient for different species based on the cranial thickness of different animals.

[0023] The scaling law relationship between species refers to the quantitative relationships that exist among different species in terms of physiological, morphological, or evolutionary characteristics in ecology and biology. These relationships often appear in the form of power laws to explain the common laws among species at different scales.

[0024] The cranial thickness is a key parameter for the damage of blast waves to the human brain. The cranial thicknesses among different species are not the same, resulting in different cranial injuries for different animals when subjected to the same blast wave. Based on this, a scaling law relationship of the blast wave attenuation coefficient for different species is established based on the cranial thickness of different animals. This blast wave attenuation coefficient takes into account the cranial thickness and can accurately represent the scaling law relationship among different species. This attenuation coefficient is used to characterize the attenuation of blast waves for different cranial thicknesses.

[0025] The calculation module 102 is used to calculate the peak incident pressure on the human forehead corresponding to different incident overpressure durations based on the scaling law relationship of the blast wave attenuation coefficient for different species and the principle of consistency between the interaction mechanism at the impact point on the human head forehead and the peak intracranial pressure.

[0026] Considering the differences in intracranial pressure responses to blast waves among different species, this application focuses on frontal explosions and explores the reflection amplification mechanism of blast waves at the impact point on the forehead and the direct transmission mechanism within the frontal cranial bone.

[0027] The interaction mechanism at the impact point on the human head forehead is the frontal pressure reflection mechanism. The frontal pressure reflection mechanism means that when a blast wave interacts with an animal or the human head, reflection will occur, and the amplification coefficient of the reflected pressure can be analyzed theoretically. The density and modulus of the head structure are significantly higher than those of air, and the head can be approximated as a rigid wall. When subjected to a frontal blast wave, the impact area on the human forehead is almost parallel to the front of the blast wave (as Figure 2 shown). Therefore, the peak reflected pressure at the impact point on the human forehead can be estimated using the normal reflection formula of the blast wave, which is shown as follows: , where, represents the atmospheric pressure, represents the peak reflected pressure, represents the impact pressure of the blast wave.

[0028] The interaction mechanism of the impact points on the human head forehead also involves the skull attenuation mechanism, that is, the scaling law relationship of the explosion shock wave attenuation coefficient. Therefore, when calculating the peak pressure of the human forehead here, it is still necessary to calculate in combination with the scaling law relationship of the explosion shock wave attenuation coefficient of different species.

[0029] In the embodiment of the present application, the principle of consistency of intracranial pressure peak means that the intracranial pressure peaks at the impact points of humans and specific species are equal.

[0030] The survival curve establishment module 103 is used to establish a 50% survival curve of human craniocerebral blast injury based on the incident pressure peak of the human forehead corresponding to different incident overpressure durations.

[0031] There is a certain relationship between the incident overpressure duration and the incident pressure peak of the human forehead. Generally, it is considered that the longer the incident overpressure duration, the gradually lower the corresponding incident pressure peak of the human forehead. Therefore, based on the incident pressure peak of the human forehead corresponding to different incident overpressure durations, a 50% survival curve of human craniocerebral blast injury can be established, and this curve can be used as the basis for evaluating the dose-effect relationship of human craniocerebral injury.

[0032] The evaluation module 104 is used to obtain the explosion overpressure peak and the incident overpressure duration in the area where the person to be evaluated is located, and combine the 50% survival curve of human craniocerebral blast injury to evaluate the dose-effect relationship of the craniocerebral injury of the person to be evaluated.

[0033] When evaluating the dose-effect relationship of the craniocerebral injury of the person to be evaluated, obtain the explosion overpressure peak and the incident overpressure duration in the area where the person to be evaluated is located, and directly evaluate the dose-effect relationship of the craniocerebral injury of the person to be evaluated based on the relationship between the explosion overpressure peak and the incident overpressure duration in the area where the person to be evaluated is located and the 50% survival curve of human craniocerebral blast injury. This device takes into account the explosion shock wave attenuation coefficients of different skull thicknesses, establishes the scaling law relationship of the explosion shock wave attenuation coefficients of different species, transitions the dose-effect relationship of experimental animal craniocerebral injury to humans, and establishes the dose-effect relationship of human craniocerebral injury. This device does not involve ethical restrictions on humans, and this device can quickly and accurately evaluate the dose-effect relationship of human craniocerebral injury.

[0034] In an alternative embodiment of the present application, the calculation module 102 includes: The determination sub-module 1021 is used to determine the explosion wave reflection coefficient of different animal heads based on the incident angle of the explosion wave at the foreheads of different animals.

[0035] Since the human forehead can be approximated as a rigid wall, it is considered that when subjected to a frontal blast wave, the impact area of the human forehead is almost parallel to the front of the blast wave. However, the geometric structure of the animal head is different from that of humans. Under the action of a frontal blast wave, the animal head is usually at a certain angle to the wave front. The semi-empirical results can be used to describe the influence of this angle on the blast wave reflection coefficient, and different peak incident blast pressures result in different reflection coefficients.

[0036] Based on this, first determine the incident angle of the blast wave at the forehead of different animals, and then further determine the blast wave reflection coefficient of different animal heads through the incident angle.

[0037] Exemplarily, for the common peak head injury pressure of 200 kPa, the relationship between the reflection coefficient and the incident angle is obtained (as Figure 3 shown). When the incident angle is less than 45°, it is regular reflection, and for larger angles, it is Mach reflection. Based on the relationship between the reflection coefficient and the incident angle, the corresponding reflection coefficient can be obtained based on the incident angle. Taking the mouse head as an example, at an incident angle of 65°, the reflection coefficient is 1.45.

[0038] In addition to mice, the incident angles of different animals (such as New Zealand rabbits, pigs, etc.) are as Figure 4 shown. The incident angle of the New Zealand rabbit head is 65°, and the incident angle of the pig head is 70°. Combining Figure 3 the reflection coefficients of different species under a 200 kPa blast wave can be obtained. For example, the frontal angle of the New Zealand rabbit is the same as that of the mouse head, and its reflection coefficient is also 1.45. The frontal angle of the pig is 70°, and its reflection coefficient is 1.30.

[0039] The acquisition sub-module 1022 is used to acquire the transmission coefficient at the forehead of animals with different cranial thicknesses.

[0040] Considering that the cranial thickness at the forehead is a key factor affecting the pressure transmission of the blast shock wave, the corresponding transmission coefficient at the forehead is obtained through the cranial thicknesses of different animals. The transmission coefficients of different animals are acquired by this acquisition sub-module for subsequent calculation of the global maximum intracranial pressure peak of different animal heads.

[0041] The first calculation sub-module 1023 is used to calculate the global maximum intracranial pressure peak of different animal heads based on the blast wave reflection coefficient and the transmission coefficient at the forehead of different animal heads, as well as the impact pressure.

[0042] The global maximum intracranial pressure peak of different animal heads is calculated through the impact pressure of the blast shock wave, as well as the blast wave reflection coefficient and the transmission coefficient at the forehead of different animal heads.

[0043] The impact pressure of the above-mentioned blast shock wave can be obtained by a blast shock wave detection device, and the electric sensor in the device directly detects the impact pressure of the blast wave.

[0044] A second calculation sub-module 1024, configured to calculate the peak incident pressure on the human forehead corresponding to different incident overpressure durations based on the principle that the peak value of the human head injury pressure is equal to the peak value of the global maximum intracranial pressure of the heads of different animals, and the function of the change of the intracranial pressure peak value with time among different animals.

[0045] Establish a calculation formula based on the principle that the peak value of the human head injury pressure is equal to the peak value of the global maximum intracranial pressure of the heads of different animals, and calculate the peak incident pressure on the human forehead corresponding to different incident overpressure durations according to the function of the change of the intracranial pressure peak value with time among different animals.

[0046] In an optional embodiment of the present application, the scale law relationship of the blast shock wave attenuation coefficients of different species established in the above relationship establishment module is expressed as follows: , In this relationship, represents the skull thickness of different animals, and η represents the attenuation coefficient.

[0047] In a specific embodiment, calculate the blast shock wave attenuation coefficients of the following five animals: 0.2 kg rats, 12 kg beagle dogs, 15 kg Bama mini-pigs, 30 kg Bama mini-pigs, and 70 kg domestic pigs. The skull thicknesses of the above five animals are 0.7±0.3 mm (rats), 3.0±0.5 mm (beagle dogs), 3.68±0.86 mm (15 kg Bama mini-pigs), 8.0±1.2 mm (30 kg Bama mini-pigs), and 9.74±1.74 mm (70 kg domestic pigs), and the calculation results are as Figure 2 shown. The attenuation coefficients of 0.2 kg rats, 12 kg beagle dogs, 15 kg Bama mini-pigs, 30 kg Bama mini-pigs, and 70 kg domestic pigs are 2%, 15%, 19%, 31%, and 45% in sequence (this result is as Figure 5 shown).

[0048] Based on the above implementation manner, the transmission coefficient at the forehead in the acquisition sub-module 1022 can be calculated by the following unit: An acquisition unit 10221, configured to acquire the intracranial pressure and surface pressure of animals with different skull thicknesses.

[0049] Since the transmission coefficient at the forehead is related to the skull thickness of the animal, and the transmission coefficient is related to the intracranial pressure and surface pressure. Based on this, first acquire the intracranial pressure and surface pressure of animals with different skull thicknesses.

[0050] A calculation unit 10222, configured to calculate a transmission coefficient at the forehead based on intracranial pressure and surface pressure of animals with different skull thicknesses.

[0051] After obtaining the intracranial pressure and surface pressure of animals with different skull thicknesses, the transmission coefficient at the forehead is calculated through the intracranial pressure and the surface pressure.

[0052] In an embodiment of the present application, the transmission coefficient at the forehead is the ratio of the intracranial pressure to the surface pressure. Exemplarily, it is detected that the intracranial pressure of animal A is m and the surface pressure is n, and the transmission coefficient at the forehead of animal A = m / n%.

[0053] In a specific embodiment, considering that the skull thickness at the forehead is a key factor affecting the pressure transmission of the blast shock wave. In this application, the pressure transmission coefficients of the foreheads of experimental animals with different skull thicknesses are measured through field real explosion experiments. The real explosion experiments are carried out at the 901 base of the China Academy of Engineering Physics. Spherical TNT explosives with different equivalents (2.7 kg, 1.9 kg, 8 kg) are used as the explosion source, the height of the explosion center is set to 2.0 meters, and the explosives are directly detonated by No. 26 detonators. The experimental animals include 200 g rats, 12 kg beagle dogs, 15 kg Bama mini-pigs, 30 kg Bama mini-pigs, and 70 kg domestic pigs, and the skull thicknesses are 0.7±0.3 mm (rats), 3.0±0.5 mm (beagle dogs), 3.68±0.86 mm (15 kg Bama mini-pigs), 8.0±1.2 mm (30 kg Bama mini-pigs), and 9.74±1.74 mm (70 kg domestic pigs). Piezoelectric sensors are placed at the foreheads of different animals respectively, the sensing surfaces of the sensors are buried in the cerebrospinal fluid at the foreheads, and the PCB113B23 type sensors are used to measure the incident overpressure of the blast shock wave. Combining Figure 4 With Figure 3 , considering the influence of the forehead angles of different species on the surface pressure at the forehead after the blast shock wave is reflected. The experimental results of 15 kg Bama mini-pigs and 30 kg Bama mini-pigs are as Figure 6 shown.

[0054] Through the field real explosion experiment, it is measured that the transmission coefficient between the intracranial pressure and the surface pressure of the 15 kg Bama mini-pig is 81%, and the transmission coefficient at the forehead of the 30 kg Bama mini-pig is 68%.

[0055] According to the same operation method as above, the remaining animals (rats, beagle dogs, domestic pigs) are processed, and the forehead transmission coefficients of the experimental animals with 5 different skull thicknesses are as Figure 7As shown, the forehead transmission coefficient of rats is 98%, that of beagle dogs is 85%, that of 15 kg Bama mini-pigs is 81%, that of 30 kg Bama mini-pigs is 68%, and that of domestic pigs is 55% (the results are as Figure 7 shown).

[0056] Based on the above embodiments, the first calculation sub-module 1023 is used to calculate the global maximum intracranial pressure peak of the heads of different animals The formula is as follows: , wherein, represents the incident pressure of the shock wave, represents the reflection coefficient, α represents the incident angle of the shock wave, represents the skull thickness, represents the forehead transmission coefficient corresponding to animals with different skull thicknesses.

[0057] The above formula can be used to calculate the global maximum intracranial pressure peak of the human head and help calculate the peak intracranial pressure response of various species, so as to quantify the severity of brain injury caused by blast waves.

[0058] Based on the above embodiments, the second calculation sub-module 1024 includes: A calculation unit for calculating the blast wave attenuation coefficient and transmission coefficient at the human forehead based on the scaling law relationship of the blast wave attenuation coefficients of different species and the skull thickness at the human forehead.

[0059] After calculating the blast wave attenuation coefficients of different species, the blast wave attenuation coefficient at the human forehead is deduced through the skull thickness at the human forehead. Then, the transmission coefficient at the human forehead is calculated based on the blast wave attenuation coefficient at the human forehead.

[0060] Specifically, assuming that the blast wave attenuation coefficient at the human forehead is x%, the transmission coefficient at the human forehead = 1 - x%.

[0061] Exemplarily, based on the scaling law relationship of the blast wave attenuation coefficients of different species, calculated according to the skull thickness at the human forehead of 6.9 ± 1.5 mm, the blast wave attenuation coefficient at the human forehead is 18% - 32%, and the transmission coefficient is 68% - 82%.

[0062] Based on the above embodiments, by using the peak intracranial pressure at the same forehead impact point in different species as a benchmark, a cross-species correlation between the blast wave exposure load and the incidence of blast-induced brain injury can be established, and then the evaluation of human craniocerebral injury can be carried out. Taking humans and a specific species as an example, if the peak intracranial pressure at the impact point is equal, the principle that the peak human head injury pressure in the second calculation sub-module is equal to the peak global intracranial pressure of different animals' heads is as follows: , where, represents the atmospheric pressure, represents the impact pressure on the human head, T represents the transmission coefficient, represents the thickness of the human skull, represents the impact pressure on different animals' heads, represents the reflection coefficient, represents the incident angle of the shock wave on different animals, represents the skull thickness of different animals.

[0063] In this formula, . By solving the peak incident pressure at the human forehead, the transfer function can be obtained: .

[0064] In the transfer function, the blast exposure threshold of animals is characterized by a function representing the variation of peak pressure with time, that is, the function of the variation of peak intracranial pressure with time among different animals is as follows: , where, , and are both special parameters in this function, and the corresponding , and parameters for each animal have their corresponding values.

[0065] For example, in this function, the parameters of New Zealand rabbits are: = 250 kPa, = 2.95, = 0.83. When the forehead angles α of pigs, rabbits, mice and humans are 20°, 25°, 25° and 90° respectively, and the forehead skull thicknesses are 9.74 mm, 2.0 mm, 0.7 mm and 6.9 mm respectively, substituting the above parameters into the transfer function, the 50% survival curve of human craniocerebral blast injury can be obtained (as shown in Figure 8 ).

[0066] In an alternative embodiment of the present application, when obtaining the 50% survival curve of human craniocerebral blast injury and conducting an evaluation in combination with this curve, the evaluation module 104 specifically includes: A first evaluation sub-module 1041, configured to evaluate that the dose-effect relationship of the craniocerebral injury of the person to be evaluated is that the probability of death is less than 50% when the point formed by the peak overpressure of the over-explosion and the incident overpressure duration in the area where the person to be evaluated is located is below the 50% survival curve of human craniocerebral blast injury.

[0067] If the point formed by the peak overpressure of the over-explosion and the incident overpressure duration in the area where the person to be evaluated is located exactly lies on the 50% survival curve of human craniocerebral blast injury, it is evaluated that the dose-effect relationship of the craniocerebral injury of the person to be evaluated is that the probability of death is equal to 50%. However, this situation is an ideal condition with a probability of zero and can be ignored.

[0068] A second evaluation sub-module 1042, configured to evaluate that the dose-effect relationship of the craniocerebral injury of the person to be evaluated is that the probability of death is greater than 50% when the point formed by the peak overpressure of the over-explosion and the incident overpressure duration in the area where the person to be evaluated is located is above the 50% survival curve of human craniocerebral blast injury.

[0069] Exemplarily, as Figure 8 shown, when it is detected that the peak overpressure of the over-explosion in the area where the person to be evaluated is located is 80 kPa and the incident overpressure duration is 5 ms, this point is below the 50% survival curve of human craniocerebral blast injury, indicating that the dose-effect relationship of the craniocerebral injury of the person to be evaluated is that the probability of death is less than 50%.

[0070] Based on the same inventive concept, the embodiments of the present application disclose an electronic device in the third aspect. Figure 9 As shown in the schematic diagram of an electronic device disclosed in the embodiments of the present application, as Figure 9 shown, the electronic device 100 includes: a memory 110 and a processor 120. The memory of the electronic device is not less than 12G, and the main frequency of the processor is not lower than 2.4 GHz. The memory 110 and the processor 120 are communicatively connected via a bus. A computer program is stored in the memory 110, and this computer program can run on the processor 120 to implement the functions of an evaluation device for the dose-effect relationship of human blast wave-induced craniocerebral injury disclosed in the embodiments of the present application.

[0071] Based on the same inventive concept, the embodiments of the present application disclose a computer-readable storage medium having a computer program / instructions stored thereon, and when the computer program / instructions are executed by a processor, the functions of an evaluation device for the dose-effect relationship of human blast wave-induced craniocerebral injury disclosed in the embodiments of the present application are implemented.

[0072] Each embodiment in this specification is described in a progressive manner. The key point of each embodiment is to illustrate the differences from other embodiments. For the same or similar parts among the embodiments, reference can be made to each other.

[0073] The embodiments of the present application are described with reference to the flowcharts and / or block diagrams of methods, devices, electronic devices, and computer program products according to the embodiments of the present application. It should be understood that each process and / or block in the flowchart and / or block diagram, as well as the combination of processes and / or blocks in the flowchart and / or block diagram, can be implemented by computer program instructions. These computer program instructions can be provided to the processor of a general-purpose computer, a special-purpose computer, an embedded processor, or other programmable data processing terminal devices to generate a machine, such that the instructions executed by the processor of the computer or other programmable data processing terminal devices generate a device for implementing the functions specified in Figure 1 one process or multiple processes and / or blocks Figure 1 one block or multiple blocks.

[0074] These computer program instructions can also be stored in a computer-readable memory that can direct a computer or other programmable data processing terminal device to work in a specific manner, such that the instructions stored in the computer-readable memory generate a manufactured article including an instruction device that implements the functions specified in Figure 1 one process or multiple processes and / or blocks Figure 1 one block or multiple blocks.

[0075] These computer program instructions can also be loaded onto a computer or other programmable data processing terminal device, such that a series of operation steps are executed on the computer or other programmable terminal device to generate a computer-implemented process. Thus, the instructions executed on the computer or other programmable terminal device provide steps for implementing the functions specified in Figure 1 one process or multiple processes and / or blocks Figure 1 one block or multiple blocks.

[0076] Although the preferred embodiments of the embodiments of the present application have been described, those skilled in the art can make additional changes and modifications once they know the basic creative concepts. Therefore, the appended claims are intended to be construed as including the preferred embodiments and all changes and modifications falling within the scope of the embodiments of the present application.

[0077] Finally, it should also be noted that in this text, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or terminal device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or further includes elements inherent to such process, method, article or terminal device. Without further limitation, an element defined by the statement "comprising an..." does not exclude the presence of additional identical elements in the process, method, article or terminal device comprising said element.

[0078] The above has introduced in detail an evaluation device, equipment and medium for the dose-effect relationship of human brain injury caused by explosion shock waves provided by the present application. Specific examples are used in this text to elaborate on the principle and implementation manner of the present application. The description of the above embodiments is only used to help understand the method and its core idea of the present application; at the same time, for those of ordinary skill in the art, according to the idea of the present application, there will be changes in the specific implementation manner and application scope. In summary, the content of this specification should not be construed as a limitation to the present application.

Claims

1. A device for evaluating the dose-effect relationship of craniocerebral injury caused by explosion shock waves in human body, characterized in that: The device comprises: A relationship building module is used to establish the scaling relationship of the explosion shock wave attenuation coefficient of different species based on the skull thickness of different animals; A calculation module is used to calculate the peak incident pressure of the human forehead corresponding to different incident overpressure durations based on the scaling relationship of the explosion shock wave attenuation coefficients of different species, the interaction mechanism of the impact point on the human forehead and the consistency principle of the peak intracranial pressure; A survival curve establishment module is used to establish a 50% survival curve for human craniocerebral blast injury based on the incident pressure peak of the human forehead corresponding to different incident overpressure durations; The evaluation module is used to obtain the explosion overpressure peak value and incident overpressure duration of the area where the person to be evaluated is located, and evaluate the dose-effect relationship of the craniocerebral injury of the person to be evaluated in combination with the 50% survival curve of the human craniocerebral explosion injury.

2. The device according to claim 1, characterized in that The scaling relationship of the explosion shock wave attenuation coefficients of different species established in the relationship establishment module is as follows: ， in, represents the skull thickness of different animals, and η represents the attenuation coefficient.

3. The device according to claim 1, characterized in that The calculation module comprises: A determination submodule, for determining the reflection coefficient of the blast wave at the head of different animals based on the incident angle of the blast wave at the forehead of different animals; An acquisition submodule, used to obtain the transmission coefficient at the forehead of animals with different skull thicknesses; The first calculation submodule is used to calculate the global maximum intracranial pressure peak value of the head of different animals based on the blast wave reflection coefficient and the transmission coefficient at the forehead of the head of different animals, as well as the impact pressure; The second calculation submodule is used to calculate the peak incident pressure of the human forehead corresponding to different incident overpressure durations based on the principle that the peak pressure of human head injury and the global maximum intracranial pressure peak of different animals' heads are equal, and the function of the change of the peak intracranial pressure between different animals over time.

4. The device according to claim 3, characterized in that The acquisition submodule includes: an acquisition unit for acquiring intracranial pressure and surface pressure in animals with different skull thicknesses; The calculation unit is used to calculate the transmission coefficient at the forehead based on the intracranial pressure and surface pressure of animals with different skull thicknesses.

5. The device according to claim 3, characterized in that The first calculation submodule is used to calculate the global maximum intracranial pressure peak value of the head of different animals The formula is as follows: ， in, represents the incident pressure of the shock wave, represents the reflection coefficient, α represents the incident angle of the shock wave, represents the thickness of the skull, Represents the forehead transmission coefficient corresponding to animals with different skull thickness.

6. The device according to claim 3, characterized in that The second calculation submodule includes: The calculation unit is used to calculate the explosion shock wave attenuation coefficient and transmission coefficient at the forehead of the human body based on the scaling relationship of the explosion shock wave attenuation coefficients of different species and the thickness of the skull at the forehead of the human body.

7. The device according to claim 6, characterized in that The principle that the peak pressure of human head injury in the second calculation submodule is equal to the peak global maximum intracranial pressure of the heads of different animals is as follows: ， in, Indicates atmospheric pressure, Indicates the impact pressure on the human head. represents the transmission coefficient of the human forehead, Indicates the thickness of the skull at the forehead of the human body. Indicates the impact pressure on the head of different animals, represents the reflection coefficient, represents the incident angle of the shock wave for different animals, represents the transmission coefficient of the forehead of different animals, Indicates the thickness of the skull of different animals.

8. The device according to claim 1, characterized in that The evaluation module includes: The first evaluation submodule is used to evaluate the dose-effect relationship of craniocerebral injury of the person to be evaluated as having a probability of death of less than 50% when the point formed by the peak value of the overexplosion overpressure and the duration of the incident overpressure in the area where the person to be evaluated is located is below the 50% survival curve of craniocerebral explosion injury of the human body; The second evaluation submodule is used to evaluate the dose-effect relationship of craniocerebral injury of the person to be evaluated as having a probability of death greater than 50% when the point formed by the peak value of the over-explosion overpressure and the duration of the incident overpressure in the area where the person to be evaluated is located is above the 50% survival curve of craniocerebral explosion injury of the human body.

9. An electronic device comprising a memory, a processor and a computer program stored in the memory, characterized in that: The processor executes the computer program to realize the function of the device for evaluating the dose-effect relationship of craniocerebral injury caused by explosion shock waves in any one of claims 1-8.

10. A computer-readable storage medium, characterized in that: A computer program / instruction is stored thereon, and when the computer program / instruction is executed by a processor, the function of the device for evaluating the dose-effect relationship of craniocerebral injury caused by explosion shock waves in human body as described in any one of claims 1-8 is realized.

Images