Coronary vein pulse ablation catheter

Abstract

The invention discloses a coronary vein pulse ablation catheter which comprises a flexible catheter. The flexible conduit forms a plurality of bent sides in a natural state, and the bent sides are sequentially connected and extend along the axial direction of the flexible conduit; a plurality of electrodes are mounted on the bent side and used for releasing a pulsed electric field to ablate a target area; the supporting piece is inserted into the inner side of the flexible catheter, the bent side is deformed when the inner side of the flexible catheter is in a stressed state, and the whole flexible catheter is in a linear shape. After the flexible catheter reaches the target area, the supporting piece is moved out, and the flexible catheter is reset in a natural state and makes contact with the target area; the device adopts a prefabricated flexible catheter which has restorability, after the device is sent into a target area through a supporting piece, the supporting piece is moved out, the catheter is made to deform and recover in a natural state, at the moment, the device is adaptive to a certain bending degree according to the condition in a blood vessel, multiple contact sites are generated between the device and the blood vessel wall, and ablation is conducted after it is judged that the catheter is attached to the target area. And the ablation effect is better.

Description

Technical Field

[0001] The present invention relates to the technical field of ablation catheters, and in particular to a coronary vein pulsed ablation catheter. Background Art

[0002] Premature ventricular contractions (PVCs), also known as ventricular premature beats, abbreviated as VPBs, refer to premature ventricular activations generated by ectopic pacemakers in the area below the bifurcation of the His bundle. Currently, in the medical market, radiofrequency ablation of the coronary vein is commonly used for the treatment of PVCs. The high temperature generated by radiofrequency is used to ablate the target, which causes high pain to the patient during the process and is prone to causing thickening of the blood vessel wall and thus forming blood vessel blockage, so it has great risks.

[0003] Pulsed Field Ablation (PFA) is a new ablation method that causes cell death based on the mechanism of irreversible electroporation. Due to its advantages such as tissue specificity and non-thermal ablation, it has been applied in the ablation of VPBs. However, the general PFA catheter is linear, and due to the irregular shape of blood vessels, there are fewer contact sites generated when it fits with the blood vessel wall after entering the blood vessel, so the treatment effect is also poor. Prolonging the ablation time is likely to cause damage to the already adhered parts due to continuous ablation. Summary of the Invention

[0004] The purpose of the present invention is to solve the deficiencies existing in the prior art, and a coronary vein pulsed ablation catheter is proposed.

[0005] To achieve the above purpose, the present invention adopts the following technical solutions: A coronary vein pulsed ablation catheter includes

[0006] A flexible catheter;

[0007] In the natural state, the flexible catheter forms several bending sides, and the bending sides are sequentially connected and extended along the axial direction of the flexible catheter;

[0008] Several electrodes are installed on the bending sides for releasing pulsed electric fields to ablate the target area;

[0009] A support member is inserted into the inner side of the flexible catheter. When the inner side of the flexible catheter is under force, the bending sides are deformed, and the whole flexible catheter is in a straight line;

[0010] After reaching the target area, the support member is removed, so that the flexible catheter is reset in the natural state and contacts the target area.

[0011] As a further description of the above technical solution: The flexible catheter includes an extension section and a bending section, and the bending section is pushed by the extension section to be in close contact with the target area for ablation.

[0012] As a further description of the above technical solution: the flexible catheter is linear under stress, cooperates with the delivery cavity of the delivery sheath, and extends outward through the delivery cavity to be delivered to the target area.

[0013] As a further description of the above technical solution: one side of the extension section is connected to the catheter seat, the catheter seat is Y-shaped, and a first interface and a second interface are provided on a side away from the extension section.

[0014] As a further description of the above technical solution: the first interface and the flexible catheter are coaxially matched, and the second interface is connected to a control device through a wire to control the electrode to generate a pulsed electric field.

[0015] As a further description of the above technical solution: the first interface cooperates with the support member so that the support member extends into the extension section through the first interface, contacts the inner wall of the bending section, and extends to the outside from the other side of the bending section.

[0016] As a further description of the above technical solution: the shape of the bending section is preformed, including a spiral shape or an S shape, forming a multi-point support with the target area.

[0017] As a further description of the above technical solution: a plurality of electrodes are installed on the outer side of the bending section, the number of the electrodes is an even number, and the switching of the positive and negative poles of two adjacent electrodes can be controlled by the voltage conduction direction of the control device.

[0018] As a further description of the above technical solution: the electrode is a platinum-iridium metal ring, which is connected and coated on the outside of the bending section through a wire connection.

[0019] As a further description of the above technical solution: the material of the flexible catheter is one of Pebax, TPE, PE, TPU or PTFE.

[0020] The above technical solution has the following advantages or beneficial effects:

[0021] 1. Use a prefabricated flexible catheter with recoverability. After being sent into the target area through a support, the support is removed to allow the catheter to recover its deformation in a natural state. At this time, it adapts to a certain degree of bending according to the situation in the blood vessel, and produces multiple contact points with the blood vessel wall. After the catheter is judged to be in close contact, ablation is performed to achieve a better ablation effect.

[0022] 2. The closeness of the electrode to the blood vessel wall can be monitored in real time to ensure the best effect of the operation. At the same time, it can reduce the electrolysis of water in the blood into hydrogen and oxygen under the action of electricity and form microbubbles, thereby reducing the risk of surgery. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 Schematic diagram of the connection structure of the pulsed ablation catheter proposed by the present invention;

[0024] Figure 2 Schematic diagram of the structure of the pulsed ablation catheter under a stressed state proposed by the present invention;

[0025] Figure 3 Schematic diagram of the structure of the pulsed ablation catheter in a natural state proposed by the present invention.

[0026] Legend:

[0027] 1. Flexible catheter; 11. Extension section; 12. Bending section; 2. Electrode; 3. Support member; 4. Catheter hub; 41. First interface; 42. Second interface; 5. Control device. Specific embodiments

[0028] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0029] Refer to Figures 1 - 3 , an embodiment provided by the present invention: a coronary vein pulsed ablation catheter, comprising: a flexible catheter 1; in a natural state, the flexible catheter 1 forms a plurality of bending sides, and the bending sides are sequentially connected and extended along the axial direction of the flexible catheter 1; a plurality of electrodes 2 are installed on the bending sides for releasing a pulsed electric field to ablate the target area; a support member 3 is inserted into the inner side of the flexible catheter 1, and when the inner side of the flexible catheter 1 is under stress, the bending sides are deformed, and the flexible catheter 1 as a whole is linear; after reaching the target area, the support member 3 is removed, so that the flexible catheter 1 is reset in a natural state and contacts the target area.

[0030] In this embodiment, a preformed flexible catheter is used, which has recoverability. In a natural state, the front end of the flexible catheter 1 is bent to a certain extent. When the support member 3 is inserted into the rear, the inner part of the flexible catheter 1 is stressed and deformed into a linear structure. After being sent into the target area through a delivery sheath, the support member 3 is removed, and the flexible catheter 1 deforms and recovers in a natural state. At this time, according to the situation in the blood vessel, it adapts to a certain degree of bending, generates multiple contact sites with the blood vessel wall. After judging that the flexible catheter 1 is in place, ablation is carried out, so that the ablation effect is better. Secondly, the flexible catheter in a linear state is also convenient for being transported through the delivery sheath.

[0031] The flexible catheter 1 is in a straight line when under stress, cooperates with the delivery cavity of the delivery sheath, and extends outward through the delivery cavity to be delivered to the target area. In this embodiment, the target area is the coronary vein of the heart cavity.

[0032] The flexible catheter 1 includes an extension section 11 and a bending section 12. The extension section 11 pushes the bending section 12 to be close to the target area for ablation. A plurality of electrodes 2 are installed on the outside of the bending section 12. The number of electrodes 2 is an even number. The switching of positive and negative poles of two adjacent electrodes 2 can be controlled by the control device 5 through the voltage conduction direction.

[0033] In this embodiment, the extension section 11 and the bending section 12 are integrally connected, and an electrode 2 is provided on the bending section 12. The extension section 11 pushes the bending section 12 to move to the target area, and a pulse electric field is generated by the electrode 2 for ablation treatment. The control device 5 determines whether the blood vessel wall is in contact with the motor. If so, a pulse signal can be sent to the electrode 2 to generate an electric field. The electrode 2 is a pulse electrode. Specifically, when the electrode 2 is not in contact with the blood vessel wall, the resistance value between the positive and negative poles of the electrode 2 is less than 300Ω. When the electrode 2 is in contact with the blood vessel wall, the resistance value between the positive and negative poles of the electrode 2 is greater than 350Ω. This is used to determine whether the bending section 12 is in contact with the blood vessel wall. Furthermore, the technical solution of the present invention may be provided with multiple pairs of electrodes 2, so that the bending section 12 is divided into several detection sections. After detection, the degree of adhesion of the bending section 12 can be detected one by one, and the adhesion performance can be monitored in real time.

[0034] In conjunction with the accompanying drawings, one side of the extension section 11 is connected to the catheter seat 4, and the catheter seat 4 is Y-shaped. A first interface 41 and a second interface 42 are provided on the side away from the extension section 11. The first interface 41 is coaxially matched with the flexible catheter 1, and the second interface 42 is connected to the control device 5 through a wire to control the electrode 2 to generate a pulsed electric field.

[0035] In this embodiment, the second interface 42 of the catheter seat 4 is connected to the control device 5, the first interface 41, and the first interface 41 is matched with the support member 3, so that the support member 3 extends into the extension section 11 through the first interface 41, and contacts the inner wall of the bending section 12, and extends to the outside from the other side of the bending section 12. At this time, the extended part of the support member 3 can be used as a guide wire to guide the delivery position of the flexible catheter 1.

[0036] In another specific embodiment, the side 4 of the flexible catheter 1 away from the catheter seat is an arc-shaped semi-opening, the support member 3 is a metal wire, and a guide wire gradient form is adopted. The head end 10-20 cm is a tapered section, which can extend out of the head end of the flexible catheter 1. A boss is provided at the rear of the support member 3, and the boss extends radially. The length is greater than the semi-opening diameter, so that the rear end of the boss cannot extend out of the outside of the flexible catheter 1.

[0037] The shape of the bent section 12 is preformed, including a spiral shape or an S shape, preferably a spiral shape, which forms multi-point support with the target area for electric field ablation.

[0038] PFA mainly causes damage to cells through pulsed electric fields. However, the electric field strength rapidly decays with the square of the distance. Therefore, a good assessment of apposition can effectively improve the treatment effect. At the same time, the better the apposition effect, the lower the energy required to be delivered by the system, reducing the content of hydrogen and oxygen generated by the electrolysis of water in the blood under the action of electricity, generating fewer microbubbles, further reducing the potential complications that may occur in patients, being safer, and further promoting the treatment effect.

[0039] The electrode 2 is a platinum-iridium metal ring, which is connected by a wire and coated on the outer side of the bent section 12. When the bent section 12 contacts the blood vessel wall, the electrode 2 contacts the blood vessel wall for ablation; the material of the flexible catheter 1 is one of Pebax, TPE, PE, TPU or PTFE.

[0040] Finally, it should be noted that the above are only the preferred embodiments of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A coronary vein pulse ablation catheter, characterized in that: include Flexible conduit (1); The flexible conduit (1) forms a plurality of bent sides in a natural state, and the bent sides are sequentially connected and extended along the axial direction of the flexible conduit (1); The bent side is provided with a plurality of electrodes (2) for releasing a pulse electric field to ablate the target area; The inner side of the flexible conduit (1) is inserted into a support member (3), and the inner side of the flexible conduit (1) is subjected to force, so that the bent side is deformed, and the flexible conduit (1) is in a straight line as a whole; After reaching the target area, the support member (3) is removed, so that the flexible catheter (1) is reset in a natural state and comes into contact with the target area.

2. A coronary vein pulse ablation catheter according to claim 1, characterized in that: The flexible catheter (1) comprises an extension section (11) and a bending section (12), and the bending section (12) is pushed by the extension section (11) to abut against the target area for ablation.

3. The coronary vein pulse ablation catheter according to claim 1, characterized in that: The flexible catheter (1) is in a straight line when under stress, cooperates with the delivery cavity of the delivery sheath tube, and extends outward through the delivery cavity to be delivered to the target area.

4. The coronary vein pulse ablation catheter according to claim 2, characterized in that: One side of the extension section (11) is connected to a catheter seat (4); the catheter seat (4) is Y-shaped and is provided with a first interface (41) and a second interface (42) on a side away from the extension section (11).

5. The coronary vein pulse ablation catheter according to claim 4, characterized in that: The first interface (41) is coaxially matched with the flexible catheter (1), and the second interface (42) is connected to a control device (5) via a wire to control the electrode (2) to generate a pulsed electric field.

6. The coronary vein pulse ablation catheter according to claim 4, characterized in that: The first interface (41) cooperates with the support member (3) so that the support member (3) extends into the extension section (11) through the first interface (41) and contacts the inner wall of the bending section (12), extending from the other side of the bending section (12) to the outside.

7. The coronary vein pulse ablation catheter according to claim 2, characterized in that: The shape of the bending section (12) is preformed, including a spiral shape or an S shape, and forms a multi-point support with the target area.

8. The coronary vein pulse ablation catheter according to claim 5, characterized in that: A plurality of electrodes (2) are installed on the outer side of the bending section (12), the number of the electrodes (2) is an even number, and the switching of positive and negative poles of two adjacent electrodes (2) can be controlled by the voltage conduction direction of the control device (5).

9. The coronary vein pulse ablation catheter according to claim 2, characterized in that: The electrode (2) is a platinum-iridium metal ring, which is connected and coated on the outside of the bent section (12) via a wire.

10. The coronary vein pulse ablation catheter according to claim 1, characterized in that: The material of the flexible conduit (1) is one of Pebax, TPE, PE, TPU or PTFE.

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