High-voltage electric pulse treatment system and device based on impedance optimization treatment parameters

Abstract

The invention is suitable for the field of medical instruments, and provides a high-voltage electric pulse treatment system and device based on impedance optimization treatment parameters. In the embodiment of the invention, the system firstly determines the impedance variable quantity of the target tissue through the high-voltage impedance monitoring module, and then determines the target voltage and the pulse width according to the impedance variable quantity, the current voltage and the pulse width as well as the preset voltage adjustment coefficient, the pulse width sensitivity and the initial reference impedance; and finally, generating a corresponding high-voltage point pulse through the target voltage and the pulse width, thereby achieving the adjustment of the treatment parameters according to the real-time impedance value, and solving the problem of excessive treatment or insufficient treatment caused by the change of the impedance value.

Description

Technical Field

[0001] The present application relates to the field of medical devices, and particularly to a high-voltage electric pulse treatment system and device based on impedance-optimized treatment parameters. Background Art

[0002] The IRE treatment technology is a new non-thermal ablation technology, which has currently been applied to the ablation treatment of tumors and atrial fibrillation. This technology has the characteristics of being electric field-dependent, not causing thermal damage, and having a controllable action range. One of the core elements of the IRE treatment technology is a high-voltage electric pulse generator, which generates specific pulse energy and conducts it into the tissue for treatment. However, the existing IRE treatment devices output with fixed parameters and cannot adapt to the dynamic changes of tissue impedance during the treatment process (such as the change in conductivity caused by electroporation), resulting in problems of over-treatment or under-treatment. Summary of the Invention

[0003] In view of this, the present application provides a high-voltage electric pulse treatment system and device based on impedance-optimized treatment parameters. By monitoring the impedance value, the voltage and pulse width can be adjusted according to the dynamic changes of the impedance value, thereby solving the problems of over-treatment or under-treatment.

[0004] The first aspect of the present application provides a high-voltage electric pulse treatment system based on impedance-optimized treatment parameters. The system includes a high-voltage impedance monitoring module, a pulse voltage adjustment module, a pulse width adjustment module, and an electric pulse energy generation module;

[0005] The high-voltage impedance monitoring module is configured to transmit an alternating current signal to the target tissue, measure the real-time voltage and excitation current at both ends of the target tissue, then determine the real-time impedance value of the target tissue through the real-time voltage and excitation current, and determine the impedance change amount through the real-time impedance value;

[0006] The pulse voltage adjustment module is configured to determine a target voltage according to the impedance change amount, real-time voltage, preset voltage adjustment coefficient, and preset initial reference impedance, and send the target voltage to the electric pulse energy generation module;

[0007] The pulse width adjustment module is configured to determine a target pulse width according to the real-time pulse width, the impedance change amount, preset pulse width sensitivity, and preset initial reference impedance, and send the target pulse width to the electric pulse energy generation module;

[0008] The high-voltage electric pulse energy generation module includes a high-voltage electric pulse generator, which is configured to generate a high-voltage electric pulse according to the treatment parameters and transmit the high-voltage electric pulse to the target tissue for treatment, where the treatment parameters at least include voltage and pulse width.

[0009] Optionally, determining the target voltage based on the impedance change amount, the real-time voltage, a preset voltage adjustment coefficient, and a preset initial reference impedance includes:

[0010] Calculating through the formula to obtain the target voltage, where V t+1 is the target voltage, V t is the real-time voltage, ΔZ t is the impedance change amount, K v is the voltage adjustment coefficient, and Z0 is the initial reference impedance.

[0011] Optionally, determining the target pulse width based on the real-time pulse width, the impedance change amount, a preset pulse width sensitivity, and a preset initial reference impedance includes:

[0012] Calculating through the formula to obtain the target pulse width, where PW new is the target pulse width, PW old is the real-time pulse width, K pw is the pulse width sensitivity, Z0 is the initial reference impedance, and |ΔZ| is the absolute value of the impedance change amount.

[0013] Optionally, the high-voltage electric pulse energy generation module further includes an energy storage module;

[0014] The energy storage module is configured to store the high-voltage electric pulse after the high-voltage electric pulse generator generates the high-voltage electric pulse, and perform the step of transmitting the high-voltage electric pulse to the target tissue for treatment after receiving an instruction.

[0015] Optionally, the high-voltage electric pulse energy generation module further includes a current detection module, which is configured to detect the current between electrodes through a current sensor when the high-voltage electric pulse generator generates the high-voltage electric pulse, and give an alarm when it is determined that the current exceeds a safety threshold.

[0016] A second aspect of the present application provides a high-voltage electric pulse treatment device based on impedance-optimized treatment parameters, and the device includes:

[0017] A high-voltage impedance monitoring unit, configured to transmit an alternating current signal to the target tissue, measure the real-time voltage and excitation current at both ends of the target tissue, then determine the real-time impedance value of the target tissue through the real-time voltage and excitation current, and determine the impedance change amount through the real-time impedance value;

[0018] A pulse voltage adjustment unit, configured to determine a target voltage according to the impedance change amount, the real-time voltage, a preset voltage adjustment coefficient, and a preset initial reference impedance, and send the target voltage to the electric pulse energy generation module;

[0019] A pulse width adjustment unit, configured to determine a target pulse width according to the real-time pulse width, the impedance change amount, a preset pulse width sensitivity, and a preset initial reference impedance, and send the target pulse width to the electric pulse energy generation module;

[0020] A high-voltage electric pulse energy generation unit, configured to generate a high-voltage electric pulse according to treatment parameters through a high-voltage electric pulse generator, and emit the high-voltage electric pulse to a target tissue for treatment, where the treatment parameters at least include voltage and pulse width.

[0021] Optionally, the determining, by the pulse voltage adjustment unit, the target voltage according to the impedance change amount, the real-time voltage, the preset voltage adjustment coefficient, and the preset initial reference impedance includes:

[0022] Calculating through the formula to obtain the target voltage, where V t+1 is the target voltage, V t is the real-time voltage, ΔZ t is the impedance change amount, K v is the voltage adjustment coefficient, and Z0 is the initial reference impedance.

[0023] Optionally, the determining, by the pulse width adjustment unit, the target pulse width according to the real-time pulse width, the impedance change amount, the preset pulse width sensitivity, and the preset initial reference impedance includes:

[0024] Calculating through the formula to obtain the target pulse width, where PW new is the target pulse width, PW old is the real-time pulse width, K pw is the pulse width sensitivity, Z0 is the initial reference impedance, and |ΔZ| is the absolute value of the impedance change amount.

[0025] Optionally, the device further includes:

[0026] An energy storage unit, configured to store the high-voltage electric pulse after the high-voltage electric pulse generator generates the high-voltage electric pulse, and perform the step of emitting the high-voltage electric pulse to the target tissue for treatment after receiving an instruction.

[0027] Optionally, the device further includes:

[0028] A current detection unit is used to detect the current between electrodes through a current sensor when the high-voltage pulse generator generates high-voltage pulses, and issue an alarm when it is determined that the current exceeds the safety threshold.

[0029] In the embodiment provided by the present application, the impedance change amount of the target tissue is first determined by the high-voltage impedance monitoring module, and then the target voltage and pulse width are determined according to the impedance change amount, the current voltage and pulse width, and the preset voltage adjustment coefficient, pulse width sensitivity, and initial reference impedance. Finally, corresponding high-voltage pulses are generated by the target voltage and pulse width, thereby realizing the adjustment of treatment parameters according to the real-time impedance value, and solving the problem of over-treatment or under-treatment caused by the change of impedance value. Description of the Drawings

[0030] Figure 1 It is a system module diagram provided by an embodiment of the present application;

[0031] Figure 2 It is a device structure diagram provided by an embodiment of the present application;

[0032] Figure 3 It is a schematic internal structure diagram of a computer device provided by an embodiment of the present application. Detailed Embodiments

[0033] Here, the exemplary embodiments will be described in detail, and the examples are shown in the drawings. When the following description refers to the drawings, unless otherwise indicated, the same numbers in different drawings represent the same or similar elements. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present application. On the contrary, they are only examples of devices and methods consistent with some aspects of the present application as detailed in the appended claims.

[0034] The terms used in the present application are only for the purpose of describing specific embodiments and are not intended to limit the present application. The singular forms "a", "the", and "said" used in the present application and the appended claims are also intended to include the plural forms unless the context clearly indicates otherwise. It should also be understood that the term "and / or" used herein refers to and includes any or all possible combinations of one or more of the associated listed items.

[0035] It should be understood that although the terms first, second, third, etc. may be used in the present application to describe various information, these information should not be limited to these terms. These terms are only used to distinguish the same type of information from each other. For example, without departing from the scope of the present application, the first information may also be referred to as the second information, and similarly, the second information may also be referred to as the first information. Depending on the context, the word "if" as used herein may be interpreted as "when" or "when" or "in response to a determination".

[0036] The present application provides a high-voltage electric pulse therapy system based on impedance-optimized treatment parameters to solve the problems of over-treatment or under-treatment caused by changes in impedance values during pulse treatment.

[0037] The technical solutions of the present application will be described in detail below with specific embodiments. These specific embodiments can be combined with each other, and the same or similar concepts or processes may not be repeated in some embodiments.

[0038] As Figure 1 shown, it is a module diagram of a high-voltage electric pulse therapy system based on impedance-optimized treatment parameters provided by the present application. The functions and effects of each module will be described below.

[0039] 1. High-voltage impedance monitoring module. This module is used to transmit and apply an alternating current signal to the target tissue, measure the real-time voltage and excitation current at both ends of the target tissue, then determine the real-time impedance value of the target tissue through the real-time voltage and excitation current, and determine the impedance change amount through the real-time impedance value.

[0040] In this embodiment, first, a high-frequency alternating current signal is applied to the target tissue through a signal source, and the signal source can be DDS direct digital synthesis or PWM + filtering to generate a sine wave. Then voltage sampling is performed, that is, the pulse voltage at both ends of the target tissue is detected through a high-input impedance differential amplifier; then current sampling is performed through a series of precision sampling resistors to calculate the excitation current. It should be noted that during the voltage and current sampling process, it is necessary to ensure that the voltage and current signals are sampled simultaneously to avoid phase errors. After sampling, first perform filtering, and then use the formula Z t =V t / I t to calculate the amplitude value, and the real-time impedance value Z t can be obtained. V t , I t are the filtered real-time voltage and current at time t respectively.

[0041] After determining the real-time impedance value Z t , through the current real-time impedance value and the real-time impedance value of the previous moment, that is, through the formula ΔZ t =Z t -Z t-1 the impedance change amount ΔZ t at time t can be determined.

[0042] 2. Pulse voltage adjustment module. This module is used to determine the target voltage according to the impedance change amount, real-time voltage, preset voltage adjustment coefficient, and preset initial reference impedance, and send the target voltage to the electric pulse energy generation module.

[0043] In this embodiment, the average impedance in the stable state before the start of treatment, such as the mean value of the first three pulses, can be used as the initial reference impedance. The voltage adjustment coefficient can control the sensitivity of voltage change, which is determined by optimizing according to clinical data, and corresponding values can be preset for different tissues respectively. For example, 0.5 is commonly used in the treatment of liver cancer.

[0044] In another embodiment, it can be calculated through the formula to obtain the target voltage, where V t+1 is the target voltage, that is, the voltage at the next moment V t , V t is the real-time voltage, ΔZ t is the impedance change amount, Kv is the voltage adjustment coefficient, and Z0 is the initial reference impedance.

[0045] In this embodiment, when irreversible electroporation of the tissue causes a decrease in impedance and an increase in conductivity, the voltage needs to be increased to maintain the effective electric field strength. For example, when V t = 800V, Kv = 0.5, Z0 = 1000Ω, when the impedance decreases and ΔZ t = -150Ω, the target voltage V t+1 = 860V can be determined according to the voltage adjustment formula. Then, by continuously monitoring the impedance and cyclically adjusting the voltage until the treatment ends. In this embodiment, the automatic adjustment of the pulse voltage can be realized through the impedance change amount of the target tissue during the treatment process, thereby reducing the occurrence of over-treatment or under-treatment.

[0046] 3. Pulse width adjustment module. This module is used to determine the target pulse width according to the real-time pulse width, the impedance change amount, the preset pulse width sensitivity, and the preset initial reference impedance, and send the target pulse width to the electric pulse energy generation module.

[0047] Since the pulse width needs to change in coordination when the voltage changes to maintain the stability of the total energy density in the treatment area. Therefore, in this embodiment, when the impedance value changes, resulting in a change in the pulse voltage, the pulse width is synchronously adjusted according to the change in the impedance value. The pulse width sensitivity can be optimized through clinical data, and corresponding values can be preset for different tissues respectively. For example, 0.3 is commonly used in the treatment of liver cancer.

[0048] In another embodiment, it can be calculated through the formula to obtain the target pulse width, where PW new is the target pulse width, PW old is the real-time pulse width, K pw is the pulse width sensitivity, Z0 is the initial reference impedance, and is the absolute value of the impedance change amount. Taking the treatment of liver cancer as an example, PW old= 100 μs, Kpw = 0.3, |ΔZ| = 200 Ω, Z0 = 1000 Ω. According to the pulse width adjustment formula, PW can be determined. new = 94 μs. Then the pulse width for the next moment is adjusted to 94 μs. By continuously monitoring the impedance and adjusting the pulse width in a loop until the treatment ends. In this embodiment, the automatic adjustment of the pulse width can be achieved through the impedance change amount of the target tissue during the treatment process, thereby reducing the occurrence of over-treatment or under-treatment.

[0049] 4. High-voltage electric pulse energy generation module. This module includes a high-voltage electric pulse generator, which is used to generate high-voltage electric pulses according to treatment parameters and transmit the high-voltage electric pulses to the target tissue for treatment. Among them, the treatment parameters at least include voltage and pulse width.

[0050] In this embodiment, the initial treatment parameters such as voltage, pulse width, electric field strength, and pulse frequency can be determined according to the patient's preoperative information, such as preoperative CT images, preoperative treatment plans, etc. After generating high-voltage electric pulses according to the treatment parameters, the voltage and pulse width in the treatment parameters are adjusted according to the target voltage and target pulse width determined by the high-voltage impedance monitoring module and the pulse voltage adjustment module. Then, high-voltage electric pulses are generated according to the adjusted treatment parameters, and the voltage and pulse width are adjusted in a loop until the treatment ends.

[0051] This module can also provide a user interface, which allows the operator to set treatment parameters and real-time display treatment parameters, energy output status, and safety monitoring information, so that the operator can start or stop the treatment.

[0052] So far, the Figure 1 function descriptions of each module are completed.

[0053] In the embodiment of the present application, the system first determines the impedance change amount of the target tissue through the high-voltage impedance monitoring module, then determines the target voltage and pulse width according to the impedance change amount, the current voltage and pulse width, and the preset voltage adjustment coefficient, pulse width sensitivity, and initial reference impedance. Finally, corresponding high-voltage point pulses are generated through the target voltage and pulse width, thus realizing the adjustment of treatment parameters according to the real-time impedance value, and solving the problem of over-treatment or under-treatment caused by the change of impedance value.

[0054] In another embodiment, the above high-voltage electric pulse energy generation module further includes an energy storage module;

[0055] The energy storage module is used to store the high-voltage electric pulse after the high-voltage electric pulse generator generates the high-voltage electric pulse, and execute the step of transmitting the high-voltage electric pulse to the target tissue for treatment after receiving an instruction.

[0056] This embodiment realizes the controllability and safety of high-voltage pulse therapy through the "storage-trigger" mechanism, and is particularly applicable to scenarios such as electro-pulse therapy that require high-precision energy delivery.

[0057] In another embodiment, the high-voltage electric pulse energy generation module further includes a current detection module, which is used to detect the current between the electrodes through a current sensor when the high-voltage electric pulse generator generates a high-voltage electric pulse, and issue an alarm when it is determined that the current exceeds the safety threshold.

[0058] This module further improves the safety and controllability of high-voltage electric pulse therapy by monitoring the current in real time and ensuring that it is within the safe threshold range.

[0059] As Figure 2 shown, the present application also provides a high-voltage electric pulse therapy device based on impedance-optimized treatment parameters, and the device includes:

[0060] A high-voltage impedance monitoring unit 201, which is used to transmit an alternating current signal to the target tissue, measure the real-time voltage and excitation current at both ends of the target tissue, then determine the real-time impedance value of the target tissue through the real-time voltage and excitation current, and determine the impedance change amount through the real-time impedance value;

[0061] A pulse voltage adjustment unit 202, which is used to determine the target voltage according to the impedance change amount, real-time voltage, preset voltage adjustment coefficient, and preset initial reference impedance, and send the target voltage to the electric pulse energy generation module;

[0062] A pulse width adjustment unit 203, which is used to determine the target pulse width according to the real-time pulse width, the impedance change amount, the preset pulse width sensitivity, and the preset initial reference impedance, and send the target pulse width to the electric pulse energy generation module;

[0063] A high-voltage electric pulse energy generation unit 204, which is used to generate a high-voltage electric pulse according to the treatment parameters through a high-voltage electric pulse generator, and emit the high-voltage electric pulse to the target tissue for treatment, where the treatment parameters at least include voltage and pulse width.

[0064] In another embodiment, the determining the target voltage in the pulse voltage adjustment unit according to the impedance change amount, real-time voltage, preset voltage adjustment coefficient, and preset initial reference impedance includes:

[0065] Calculating through the formula to obtain the target voltage, where V t+1 is the target voltage, V t is the real-time voltage, ΔZ t is the impedance change amount, K vis the voltage adjustment coefficient, and Z0 is the initial reference impedance.

[0066] In another embodiment, determining the target pulse width according to the real-time pulse width, the impedance change amount, the preset pulse width sensitivity, and the preset initial reference impedance in the pulse width adjustment unit includes:

[0067] Calculating through the formula to obtain the target pulse width, where PW new is the target pulse width, PW old is the real-time pulse width, K pw is the pulse width sensitivity, Z0 is the initial reference impedance, and |ΔZ| is the absolute value of the impedance change amount.

[0068] In another embodiment, the device further includes:

[0069] The energy storage unit 205 is configured to store the high-voltage electrical pulse after the high-voltage electrical pulse generator generates the high-voltage electrical pulse, and perform the step of transmitting the high-voltage electrical pulse to the target tissue for treatment after receiving an instruction.

[0070] In another embodiment, the device further includes:

[0071] The current detection unit 206 is configured to detect the current between the electrodes through a current sensor when the high-voltage electrical pulse generator generates a high-voltage electrical pulse, and give an alarm when it is determined that the current exceeds the safety threshold.

[0072] In the above embodiments of the present invention, a high-voltage electrical pulse treatment system based on impedance optimization of treatment parameters is provided, and a high-voltage electrical pulse treatment device based on impedance optimization of treatment parameters is provided based on this system. Through the above system and device, it is possible to adjust the treatment parameters according to the real-time impedance value, thereby solving the problems of over-treatment or under-treatment caused by impedance value changes during the pulse treatment process.

[0073] This embodiment also discloses a computer device, as Figure 3 shown. The computer device includes a processor and a memory. At least one instruction is stored in the memory, and the at least one instruction is loaded and executed by the processor to implement the method on any of the above-mentioned high-voltage electrical pulse treatment systems based on impedance optimization of treatment parameters.

[0074] In addition, in the embodiments of the high-voltage electric pulse treatment device based on impedance-optimized treatment parameters in the above examples, the logical division of each program module is only for illustrative purposes. In actual applications, according to needs, for example, considering the configuration requirements of the corresponding hardware or the convenience of software implementation, the above functions can be assigned to different program modules to complete, that is, the internal structure of the high-voltage electric pulse treatment device based on impedance-optimized treatment parameters can be divided into different program modules to complete all or part of the functions described above.

[0075] The foregoing is only a preferred embodiment of the present application and is not intended to limit the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present application shall be included within the scope of protection of the present application.

Claims

1. A high-voltage electric pulse therapy system based on impedance-optimized treatment parameters, characterized in that, The system includes a high-voltage impedance monitoring module, a pulse voltage adjustment module, a pulse width adjustment module, and an electrical pulse energy generation module; The high-voltage impedance monitoring module is configured to transmit an alternating current signal to the target tissue, measure the real-time voltage and excitation current across the target tissue, determine the real-time impedance value of the target tissue based on the real-time voltage and excitation current, and determine the impedance change amount based on the real-time impedance value; The pulse voltage adjustment module is configured to determine a target voltage based on the impedance change amount, real-time voltage, preset voltage adjustment coefficient, and preset initial reference impedance, and send the target voltage to the electrical pulse energy generation module; The pulse width adjustment module is configured to determine a target pulse width based on the real-time pulse width, the impedance change amount, preset pulse width sensitivity, and preset initial reference impedance, and send the target pulse width to the electrical pulse energy generation module; The high-voltage electrical pulse energy generation module includes a high-voltage electrical pulse generator, which is configured to generate a high-voltage electrical pulse according to treatment parameters and transmit the high-voltage electrical pulse to the target tissue for treatment, where the treatment parameters at least include voltage and pulse width.

2. The system according to claim 1, wherein The determination of the target voltage based on the impedance change amount, real-time voltage, preset voltage adjustment coefficient, and preset initial reference impedance includes: Calculate through the formula to obtain the target voltage, where V t+1 is the target voltage, V t is the real-time voltage, ΔZ t is the impedance change amount, K v is the voltage adjustment coefficient, and Z0 is the initial reference impedance.

3. The system according to claim 1, characterized in that, The determination of the target pulse width based on the real-time pulse width, the impedance change amount, preset pulse width sensitivity, and preset initial reference impedance includes: Calculate through the formula to obtain the target pulse width, where PW new is the target pulse width, PW old is the real-time pulse width, K pw is the pulse width sensitivity, Z0 is the initial reference impedance, and |ΔZ| is the absolute value of the impedance change amount.

4. The system according to claim 1, wherein The high-voltage electrical pulse energy generation module further includes an energy storage module; The energy storage module is configured to store the high-voltage electrical pulse after the high-voltage electrical pulse generator generates the high-voltage electrical pulse, and perform the step of transmitting the high-voltage electrical pulse to the target tissue for treatment after receiving an instruction.

5. The system according to claim 1, characterized in that The high-voltage electrical pulse energy generation module further includes a current detection module, which is configured to detect the current between electrodes through a current sensor when the high-voltage electrical pulse generator generates a high-voltage electrical pulse, and issue an alarm when it is determined that the current exceeds a safety threshold.

6. A high-voltage electric pulse treatment device based on impedance-optimized treatment parameters, characterized in that, The device includes: A high-voltage impedance monitoring unit, configured to transmit an alternating current signal to the target tissue, measure the real-time voltage and excitation current across the target tissue, determine the real-time impedance value of the target tissue based on the real-time voltage and excitation current, and determine the impedance change amount based on the real-time impedance value; A pulse voltage adjustment unit, configured to determine a target voltage based on the impedance change amount, real-time voltage, preset voltage adjustment coefficient, and preset initial reference impedance, and send the target voltage to the electrical pulse energy generation module; A pulse width adjustment unit, configured to determine a target pulse width based on the real-time pulse width, the impedance change amount, preset pulse width sensitivity, and preset initial reference impedance, and send the target pulse width to the electrical pulse energy generation module; A high-voltage electrical pulse energy generation unit, configured to generate a high-voltage electrical pulse through a high-voltage electrical pulse generator according to treatment parameters and transmit the high-voltage electrical pulse to the target tissue for treatment, where the treatment parameters at least include voltage and pulse width.

7. The device according to claim 6, characterized in that, Determining the target voltage in the pulse voltage adjustment unit according to the impedance change amount, the real-time voltage, the preset voltage adjustment coefficient, and the preset initial reference impedance includes: Calculate through the formula to obtain the target voltage, where V t+1 is the target voltage, V t is the real-time voltage, ΔZ t is the impedance change amount, K v is the voltage adjustment coefficient, and Z0 is the initial reference impedance.

8. The device according to claim 6, characterized in that, Determining the target pulse width in the pulse width adjustment unit according to the real-time pulse width, the impedance change amount, the preset pulse width sensitivity, and the preset initial reference impedance includes: Calculate through the formula to obtain the target pulse width, where PW new is the target pulse width, PW old is the real-time pulse width, K pw is the pulse width sensitivity, Z0 is the initial reference impedance, and |ΔZ| is the absolute value of the impedance change amount.

9. The device according to claim 6, characterized in that, The device further includes: An energy storage unit, configured to store the high-voltage electrical pulse after the high-voltage electrical pulse generator generates the high-voltage electrical pulse, and perform the step of transmitting the high-voltage electrical pulse to the target tissue for treatment after receiving an instruction.

10. The device according to claim 6, characterized in that, The device further includes: A current detection unit, configured to detect the current between the electrodes through a current sensor when the high-voltage electrical pulse generator generates the high-voltage electrical pulse, and give an alarm when it is determined that the current exceeds the safety threshold.

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