Facial mask as well as preparation method and application thereof

Abstract

The invention provides a mask as well as a preparation method and application thereof. The mask comprises a base membrane and a liquid plasma matrix or a liquid plasma matrix dry matter loaded in the base membrane. The mask is obtained by performing centrifugal treatment on whole blood, collecting a liquid plasma matrix, soaking a base membrane in the liquid plasma matrix for a period of time, and performing or not performing freeze drying. The facial mask provided by the invention is rich in hematogenous growth factors, has the effects of promoting soft and hard tissue increment, improving acnes, promoting postoperative repair, reducing scars, rejuvenating the face and the like, and can be used for beautifying the face and the neck.

Description

Technical Field

[0001] The present invention belongs to the technical field of biomedical materials, and particularly relates to a facial mask, a preparation method thereof, and an application thereof. Background Art

[0002] Medical aesthetics is a medical field focused on improving the appearance and physical appearance of patients through various medical techniques and aesthetic treatment methods, performed by trained and certified doctors or aesthetic specialists. Post-operative care in medical aesthetics is a series of care measures taken to ensure the best results, relieve discomfort, and reduce post-operative risks, including wound healing, discomfort relief, moisturizing skin care, infection prevention, diet, and lifestyle advice, etc., to meet the needs of patients and minimize post-operative inconveniences.

[0003] The post-operative care facial mask for medical aesthetics is a commonly used post-operative care product for medical aesthetics. Its advantages include various physiological effects, such as promoting healing and repair, moisturizing and soothing, personalized care, and convenient use, etc. Patients can conveniently use these facial masks at home, reducing the need to frequently visit hospitals or clinics. However, the effects of the facial masks vary due to individual differences, and the deficiencies include excessive irritation of the facial mask ingredients and insufficient regeneration-promoting ability, etc.

[0004] Therefore, there is a need to develop a safer facial mask with better aesthetic effects. Summary of the Invention

[0005] Aiming at the deficiencies of the existing technology, the purpose of the present invention is to provide a facial mask, a preparation method thereof, and an application thereof. This facial mask is rich in blood-derived growth factors, has the effects of promoting the increment of hard and soft tissues, improving acne, promoting post-operative repair, reducing scars, and rejuvenating the face, etc., and can be used for the aesthetics of the face and neck.

[0006] To achieve this purpose, the present invention adopts the following technical solutions:

[0007] In the first aspect, the present invention provides a facial mask, which comprises a base film, and a liquid plasma matrix or a dried product of the liquid plasma matrix loaded in the base film.

[0008] In the present invention, the liquid plasma matrix and the dried product of the liquid plasma matrix are preferably the liquid plasma matrix and the dried product of the liquid plasma matrix prepared from autologous whole blood. The facial mask prepared in this way has good autocompatibility and no immunogenicity.

[0009] Liquid plasma matrix or dried liquid plasma matrix is rich in blood-derived growth factors (such as platelet-derived growth factor (PDGF), transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor, epidermal growth factor, insulin-like growth factor (IGF), etc.), platelets, white blood cells and other bioactive substances. Liquid plasma matrix plays an important role in the fields of inflammation, wound healing, tissue regeneration, etc. In the present invention, by loading liquid plasma matrix or dried liquid plasma matrix in the base film, the obtained facial mask has the effects of promoting the increment of hard and soft tissues, improving acne, promoting postoperative repair, reducing scars, rejuvenating the face, etc.

[0010] In some embodiments of the present invention, the material of the base film is selected from one or more of non-woven fabric, silk, pure cotton fabric, wood pulp fiber, bamboo pulp fiber and synthetic fiber.

[0011] In some embodiments of the present invention, the facial mask further includes a functional substance loaded in the base film, and the functional substance is selected from one or more of bifidobacterium yeast, arbutin, niacinamide, ectoin, ceramide-3, hyaluronic acid, plant extract, tranexamic acid, ecdysterone, erythritol, vitamin E, glycerol and propylene glycol.

[0012] In a second aspect, the present invention provides a preparation method of the facial mask as described in the first aspect, and the preparation method includes the following steps:

[0013] (1) Centrifuge whole blood using a liquid plasma matrix collection tube to collect the liquid plasma matrix;

[0014] (2) Immerse the base film in the liquid plasma matrix or a mixture of the liquid plasma matrix and the functional substance for a period of time;

[0015] (3) Use the base film immersed in step (2) directly as the facial mask, or obtain the facial mask after freeze-drying.

[0016] In the present invention, the facial mask without freeze-drying is preferably used immediately, and the freeze-dried facial mask is preferably stored at a temperature of ≤ -20 °C.

[0017] In some embodiments of the present invention, the centrifugation method in step (1) is horizontal centrifugation.

[0018] In some embodiments of the present invention, the centrifugal acceleration of the centrifugation treatment is 60 - 1000g, for example, it can be 60g, 100g, 150g, 200g, 250g, 300g, 350g, 400g, 450g, 500g, 550g, 600g, 650g, 700g, 750g, 800g, 850g, 900g, 950g or 1000g, etc.; the centrifugation time is 2 - 10min, for example, it can be 2min, 2.5min, 3min, 3.5min, 4min, 4.5min, 5min, 5.5min, 6min, 6.5min, 7min, 7.5min, 8min, 8.5min, 9min, 9.5min or 10min, etc. Here, "g" is the acceleration of gravity.

[0019] The centrifuged whole blood is divided into three layers, including the upper light yellow liquid, the middle brownish - yellow liquid and the lower red blood cells. In the present invention, the liquids in the upper layer and the middle layer are collected. In the present invention, liquid plasma matrix can be collected from a liquid plasma matrix collecting tube through application devices such as syringes or pipettes, and the liquid plasma matrix and the basement membrane are mixed using a sterile vessel, or the liquid plasma matrix, the functional substance and the basement membrane are mixed.

[0020] In some embodiments of the present invention, the soaking time in step (2) is 1 - 10min; for example, it can be 1min, 2min, 3min, 4min, 5min, 6min, 7min, 8min, 9min or 10min, etc.

[0021] In some embodiments of the present invention, the freeze - drying in step (3) is carried out under vacuum conditions, and the temperature of the freeze - drying is below - 10°C, for example, it can be - 80°C, - 70°C, - 60°C, - 50°C, - 40°C, - 38°C, - 35°C, - 32°C, - 30°C, - 28°C, - 25°C, - 22°C, - 20°C, - 18°C, - 15°C, - 12°C or - 10°C, etc.; the freeze - drying time is 12 - 36h, for example, it can be 12h, 14h, 15h, 18h, 20h, 22h, 25h, 28h, 30h, 32h, 34h or 36h, etc.

[0022] In the third aspect, the present invention provides the use of a facial mask as described in the first aspect or a facial mask prepared by the preparation method as described in the second aspect in facial and neck beauty.

[0023] In the present invention, the facial and neck beauty care can be daily care or postoperative care after medical aesthetic procedures. The medical aesthetic procedures can be minimally invasive medical aesthetic procedures, such as injections, microneedles, lasers, and fillers for soft and hard tissues of the face and neck. The mask provided by the present invention can be applied to various beauty treatment purposes, such as promoting the increment of soft and hard tissues, improving acne, promoting postoperative repair, reducing scars, and rejuvenating the face, etc.

[0024] The mask provided by the present invention can be used alone for facial and neck beauty care, or can be used in combination with other beauty methods or products (such as scientific and technological introduction instruments of multi-spectrum, light wave, pulsation, etc.).

[0025] Fourthly, the present invention provides a method for using the mask as described in the first aspect or the mask prepared by the preparation method as described in the second aspect. The method for using includes the following steps:

[0026] When the mask is in a moist state, cover the mask on the part to be cared for for a period of time, then remove the mask and wait for the mask liquid to be completely absorbed;

[0027] When the mask is in a dry state, soak the mask with a solvent, cover the mask on the part to be cared for for a period of time, then remove the mask and wait for the mask liquid to be completely absorbed.

[0028] It is easy for those skilled in the art to understand that when the mask is in a moist state, the mask liquid is the liquid plasma matrix; when the mask is in a dry state, the mask liquid refers to the liquid component in the soaked mask, including the solvent and the dried liquid plasma matrix loaded in the base film. One can wait for the mask liquid to be absorbed, or can promote the absorption of the mask liquid by methods such as massage.

[0029] In some embodiments of the present invention, the solvent is selected from one or more of water, glycerol, butanediol, pentanediol, hyaluronic acid solution, and seaweed polysaccharide solution.

[0030] In some embodiments of the present invention, the covering time is 10 - 30 min, for example, it can be 10 min, 12 min, 13 min, 15 min, 16 min, 18 min, 20 min, 22 min, 23 min, 25 min, 26 min, 28 min, or 30 min, etc.

[0031] Compared with the prior art, the present invention has the following beneficial effects:

[0032] 1. The mask provided by the present invention is rich in blood-derived growth factors, can exert good biological effects, has functions such as promoting the increment of soft and hard tissues, improving acne, promoting postoperative repair, reducing scars, and rejuvenating the face, and can be used for facial and neck beauty care.

[0033] 2. The facial mask provided by the present invention can be prepared from autologous blood, has good autocompatibility, no immunogenicity, and a relatively low risk of complications.

[0034] 3. The preparation method of the facial mask of the present invention is simple and has a low cost. Detailed implementation manners

[0035] The technical solution of the present invention will be further described below through specific implementation manners. Those skilled in the art should understand that the specific implementation manners are only for helping to understand the present invention and should not be regarded as specific limitations on the present invention.

[0036] Example 1

[0037] This example provides a facial mask, which is used for facial care of patients who have undergone minimally invasive facial microneedle surgery to promote wound healing, reduce the healing time, and relieve the pain of the patients. The specific process is as follows:

[0038] (1) Collect the whole blood of the patient in a liquid plasma matrix blood collection tube, immediately use a centrifugation device to centrifuge at 700g for 8 minutes, and use a syringe to collect the upper light yellow liquid and the middle light brown liquid as the liquid plasma matrix;

[0039] (2) Immerse the silk-based membrane in the liquid plasma matrix obtained in step (1) for 1 minute;

[0040] (3) Vacuum freeze-dry the membrane soaked in step (2) at -80°C for 12 hours to obtain a facial mask, and store it for later use at -20°C;

[0041] (4) Moisten the facial mask with water, cover it on the patient's face for 20 minutes, then remove the facial mask and massage until the facial mask liquid is completely absorbed.

[0042] Example 2

[0043] This example provides a facial mask, which is used for facial care of patients with acne skin to reduce inflammation, inhibit bacterial proliferation, and relieve the pain of the patients. The specific process is as follows:

[0044] (1) Collect the whole blood of the patient in a liquid plasma matrix blood collection tube, immediately use a centrifugation device to centrifuge at 300g for 10 minutes, and use a syringe to collect the upper light yellow liquid and the middle light brown liquid as the liquid plasma matrix;

[0045] (2) Immerse the pure cotton cloth-based membrane in the liquid plasma matrix obtained in step (1) for 10 minutes;

[0046] (3) Vacuum freeze-dry the membrane soaked in step (2) at -20°C for 12 hours to obtain a facial mask, and store it for later use at -20°C;

[0047] (4) Moisten the facial mask with water, cover the patient's face for 30 min, then remove the facial mask and massage until the facial mask liquid is completely absorbed.

[0048] Example 3

[0049] This example provides a facial mask, which is used for the patient's daily facial care to make the face younger. The specific process is as follows:

[0050] (1) Collect the patient's whole blood in a liquid plasma matrix blood collection tube, immediately use a centrifugation device, centrifuge at 1000 g for 5 min, and use a syringe to collect the upper light yellow liquid and the middle light brown liquid as the liquid plasma matrix;

[0051] (2) Mix the liquid plasma matrix obtained in step (1) with nicotinamide and soak the wood pulp fiber-based membrane for 5 min;

[0052] (3) Vacuum freeze-dry the soaked base membrane in step (2) at -20 °C for 12 h to obtain a facial mask, and store it for standby at -20 °C;

[0053] (4) Moisten the facial mask with glycerol, cover the patient's face for 10 min, then remove the facial mask, and use a multi-spectrum introduction instrument to promote the absorption of the facial mask liquid.

[0054] The above are only specific embodiments of the present disclosure, enabling those skilled in the art to understand or implement the present disclosure. Various modifications to these embodiments will be obvious to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present disclosure. Therefore, the present disclosure will not be limited to these embodiments described herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A facial mask, characterized in that, The mask includes a base film, and a liquid plasma matrix or a dried product of the liquid plasma matrix loaded in the base film.

2. The facial mask according to claim 1, characterized in that, The material of the base film is selected from one or more of non-woven fabric, silk, pure cotton cloth, wood pulp fiber, bamboo pulp fiber and synthetic fiber.

3. The facial mask according to claim 1 or 2, characterized in that, The mask further includes a functional substance loaded in the base film, and the functional substance is selected from one or more of bifidobacterium, arbutin, niacinamide, ectoin, ceramide-3, hyaluronic acid, plant extract, tranexamic acid, ecdysterone, erythritol, vitamin E, glycerol and propylene glycol.

4. A method for preparing a facial mask according to any one of claims 1 to 3, characterized in that, The preparation method includes the following steps: (1) Centrifuge whole blood using a liquid plasma matrix collection tube to collect the liquid plasma matrix; (2) Immerse the base film in the liquid plasma matrix or a mixture of the liquid plasma matrix and the functional substance for a period of time; (3) Use the base film soaked in step (2) directly as the mask, or obtain the mask after freeze-drying.

5. The preparation method according to claim 4, characterized in that, The centrifugation method in step (1) is horizontal centrifugation; Preferably, the centrifugal acceleration of the centrifugation is 60-1000g, and the centrifugation time is 2-10 min.

6. The preparation method according to claim 4 or 5, characterized in that, The immersion time in step (2) is 1-10 min.

7. The preparation method according to any one of claims 4-6, characterized in that, The freeze-drying in step (3) is carried out under vacuum conditions, the temperature of the freeze-drying is below -10°C, and the time of the freeze-drying is 12-36 h.

8. Application of the mask according to any one of claims 1-3 or the mask prepared by the preparation method according to any one of claims 4-7 in facial and neck beauty.

9. A method of using a facial mask as described in any one of claims 1-3 or a facial mask prepared by the preparation method as described in any one of claims 4-7, characterized in that, The usage method includes the following steps: When the mask is in a wet state, cover the mask on the part to be cared for for a period of time, then remove the mask and wait for the mask liquid to be completely absorbed; When the mask is in a dry state, moisten the mask with a solvent, cover it on the part to be cared for for a period of time, then remove the mask and wait for the mask liquid to be completely absorbed.

10. The usage method according to claim 9, characterized in that, The solvent is selected from one or more of water, glycerol, butanediol, pentanediol, hyaluronic acid solution and seaweed polysaccharide solution; Preferably, the covering time is 10-30 min.