Application of anti-dandruff and antipruritic composition in preparation of shampoo or hair care products

Through the scientific compatibility of Chinese herbal extracts such as Artemisia rosary in shampoo or hair care products, the damage problem of chemical drugs to the scalp is solved, effective anti-dandruff and anti-itchi effect is achieved, and the safety and user experience of the product are improved.

CN120267590APending Publication Date: 2025-07-08LIUZHOU LIANGMIANZHEN
View PDF 5 Cites 0 Cited by

Patent Information

Application Number
CN202510581625.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-05-07
Publication Date
2025-07-08

AI Technical Summary

Technical Problem

Frequent use of chemical antifungal drugs commonly used in existing shampoo and hair care products may damage the scalp and hair, and the application of Chinese herbal ingredients in shampoo or hair care products has not been fully developed.

Method used

The scientific combination of Artemisia saccharomycea extract, vanilla extract, Sophora ginseng extract, Schizonepeta extract, windproof extract and conical stone flower extract is used, and it is added to shampoo or hair care products as anti-dandruff anti-itch compositions. The preparation method includes ethanol extraction and concentration, and the composition addition ratio is 0.1%-5.0%.

Benefits of technology

Effectively reduce dandruff, improve scalp itching, reduce irritation effects on the scalp, have good safety, and avoid damage to the scalp by chemical drugs.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure BDA0005390505800000051
    Figure BDA0005390505800000051
  • Figure BDA0005390505800000061
    Figure BDA0005390505800000061
  • Figure BDA0005390505800000062
    Figure BDA0005390505800000062
Patent Text Reader

Abstract

The invention provides the technical field of wash supplies, and particularly discloses application of an anti-dandruff and itching-relieving composition in preparation of hair washing or hair care products, the anti-dandruff and itching-relieving composition is prepared from artemisia annua extract, lysimachia foenum-graecum extract, radix sophorae flavescentis extract, herba schizonepetae extract, divaricate saposhnikovia root extract and gypsophila coniflora extract according to the corresponding weight ratio of (2-6): (2-5): (2-6): (4-6): (4-6): (2-6). The composition is applied to preparation of shampoo or hair care products and can help people to condition the scalp environment after being used, so that dandruff is obviously reduced, and the scalp itching condition is also obviously improved.
Need to check novelty before this filing date? Find Prior Art

Description

Technical Field

[0001] The present invention relates to the field of washing and care products, and particularly to the application of an anti-dandruff and anti-itch composition in the preparation of hair washing or hair care products. Background Art

[0002] The scalp, as the "soil" for hair growth, directly affects the quality of hair and our overall image. With the increasing attention people pay to their own image, they also attach more and more importance to scalp health. Common scalp problems include dandruff, scalp itching, and excessive scalp oiliness. Among them, dandruff directly affects personal image, and scalp itching is often unbearable, bringing a lot of inconvenience and annoyance to people's lives. More importantly, if not dealt with in time, it may also cause more serious scalp problems, such as hair loss and alopecia areata.

[0003] At present, there are various hair washing and hair care products for anti-dandruff and anti-itch on the market. Some add various antifungal drugs, such as common ketoconazole, zinc pyrithione, selenium disulfide, etc. If these drugs are used frequently, while killing fungi, they may also damage normal skin and hair, and are not suitable for long-term use. Chinese herbal medicines are the treasures of traditional Chinese medicine and are widely used in daily health preservation and recuperation in China. If Chinese herbal medicines can be applied in hair washing or hair care products to help people relieve the troubles of dandruff and scalp itching, on the one hand, it can avoid the damage of chemical drugs to the scalp to a certain extent, and on the other hand, it is also beneficial to the development and inheritance of Chinese herbal medicine culture. Summary of the Invention

[0004] The present invention provides the application of an anti-dandruff and anti-itch composition in the preparation of hair washing or hair care products. Applying a variety of Chinese herbal medicine ingredients in hair washing or hair care products can effectively help people relieve the troubles of dandruff and scalp itching.

[0005] To achieve the above object, the technical solution of the present invention is as follows:

[0006] The application of an anti-dandruff and anti-itch composition in the preparation of hair washing or hair care products, wherein the anti-dandruff and anti-itch composition is added to the hair washing or hair care product as the only active ingredient;

[0007] The anti-dandruff and anti-itch composition is prepared by mixing Artemisia annua extract, Lysimachia foenum-graecum extract, Sophora flavescens extract, Schizonepeta tenuifolia extract, Saposhnikovia divaricata extract, and Gypsophila paniculata extract in a weight ratio of 2-6:2-5:2-6:4-6:4-6:2-6.

[0008] Preferably, the anti-dandruff and anti-itch composition is prepared by mixing Artemisia annua extract, Lysimachia foenum-graecum extract, Sophora flavescens extract, Schizonepeta tenuifolia extract, Saposhnikovia divaricata extract, and Gypsophila paniculata extract in a weight ratio of 5:4:5:6:6:6.

[0009] Preferably, the weight percentage of the anti-dandruff and antipruritic composition added to the shampoo or hair care product is 0.1%-5.0%.

[0010] Preferably, the Artemisia annua extract is an ethanol extract; and / or the Lysimachia foenum-graecum extract is an ethanol extract; and / or the Sophora flavescens extract is an ethanol extract; and / or the Schizonepeta tenuifolia extract is an ethanol extract; and / or the Saposhnikovia divaricata extract is an ethanol extract; and / or the Gypsophila paniculata extract is an ethanol extract.

[0011] Preferably, the preparation process of the Artemisia annua extract includes: cold soaking and extracting with an ethanol aqueous solution 2-3 times, concentrating under reduced pressure, extracting, decolorizing, filtering, crystallizing, and drying.

[0012] Preferably, the weight of the Artemisia annua extract is calculated based on its weight concentrated to 1 / 2-1 times the weight of the original drug; and / or the weight of the Lysimachia foenum-graecum extract is calculated based on its weight concentrated to 1 / 2-1 times the weight of the original drug; and / or the weight of the Sophora flavescens extract is calculated based on its weight concentrated to 1 / 2-1 times the weight of the original drug; and / or the weight of the Schizonepeta tenuifolia extract is calculated based on its weight concentrated to 1 / 2-1 times the weight of the original drug; and / or the weight of the Saposhnikovia divaricata extract is calculated based on its weight concentrated to 1 / 2-1 times the weight of the original drug; and / or the weight of the Gypsophila paniculata extract is calculated based on its weight concentrated to 1 / 2-1 times the weight of the original drug.

[0013] Preferably, the shampoo product is shampoo, shampoo cream or shampoo soap.

[0014] Preferably, the hair care product is hair conditioner, hair mask or hair essential oil.

[0015] For the Lysimachia foenum-graecum extract, Sophora flavescens extract, Schizonepeta tenuifolia extract, Saposhnikovia divaricata extract and Gypsophila paniculata extract, the present invention provides a preferred preparation method: the corresponding original medicinal materials of the Lysimachia foenum-graecum extract, Sophora flavescens extract, Schizonepeta tenuifolia extract, Saposhnikovia divaricata extract and Gypsophila paniculata extract are respectively crushed, and heated under reflux for extraction 1-3 times with an ethanol solution with a weight-to-volume ratio of 6-10 times and a volume fraction of 75%-99%, and then concentrated under reduced pressure to 0.5-1 times the weight of the original medicinal materials.

[0016] For the Artemisia annua extract, the present invention provides a preferred preparation method: the original Artemisia annua medicinal materials are crushed, extracted and concentrated with an ethanol solution with a volume fraction of 95%-99%, extracted, decolorized, filtered, crystallized, and dried to obtain the Artemisia annua extract, and the purity of the Artemisia annua extract is ≥98%.

[0017] Of course, the extraction methods of the above extracts are not limited to the methods described above, and other methods such as supercritical extraction and ultrasonic extraction can also be used for extraction.

[0018] The Artemisia annua extract, Lysimachia foenum-graecum extract, Sophora flavescens extract, Schizonepeta tenuifolia extract, Saposhnikovia divaricata extract and Gypsophila paniculata extract of the present invention are scientifically formulated to help people condition the scalp environment, where:

[0019] Artemisia annua is the dried aerial part of Artemisia annual.L of the Compositae family, bitter in taste and slightly pungent; it has the effects of clearing heat, cooling blood, antibacterial, etc.

[0020] Lysimachia foenum-graecum is the whole aerial herb of Lysimachia foenum-graecum Hance of the Primulaceae family, sweet and light in taste, and flat in nature; it has the effects of clearing heat, promoting qi flow, and relieving pain.

[0021] Sophora flavescens is the dried root of Sophora flavescens Ait. of the Leguminosae family, bitter in taste and cold in nature; it has the effects of clearing heat, drying dampness, and killing insects.

[0022] Schizonepeta tenuifolia is the dried aerial part of Schizonepeta tenuifolia Briq. of the Labiatae family, pungent in taste and slightly warm in nature; it has the effects of inducing sweating to disperse wind, and promoting eruption. It is used for colds, headaches, measles, rubella, and the initial stage of sores and ulcers.

[0023] Saposhnikovia divaricata is the dried root of Saposhnikovia divaricata (Turcz.) Schischk. of the Umbelliferae family, pungent and sweet in taste, and slightly warm in nature; it has the effects of dispersing wind, clearing heat and detoxifying, tonifying deficiency, and promoting blood circulation.

[0024] Gypsophila paniculata is the dried root and stem of Gypsophila paniculata L. of the Caryophyllaceae family, light and slightly bitter in taste, and flat in nature; it has the effects of clearing heat and improving eyesight, and relieving pain and swelling.

[0025] The application of the above-mentioned anti-dandruff and anti-itching composition in the preparation of hair washing or hair care products has the following advantages:

[0026] (1) The anti-dandruff and anti-itching composition composed of Artemisia annua extract, Lysimachia foenum-graecum extract, Sophora flavescens extract, Schizonepeta tenuifolia extract, Saposhnikovia divaricata extract and Gypsophila paniculata extract with scientific proportioning is made of natural Chinese herbal medicines, which reduces the stimulating effect of hair washing or hair care products on the scalp, has good safety, and can avoid the damage of chemical drugs to the scalp to a certain extent.

[0027] (2) Verified by experiments, the anti-dandruff and anti-itching composition of the present invention can help people condition the scalp environment after use, significantly reduce dandruff, and also significantly improve the scalp itching situation, having a good anti-dandruff and anti-itching effect. Detailed implementation mode

[0028] To make the objectives, technical solutions, and advantages of the present invention clearer, the following will clearly and completely describe the technical solutions of the present invention in conjunction with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of them. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts belong to the scope of protection of the present invention.

[0029] Use of an anti-dandruff and anti-itching composition in the preparation of a hair washing or hair care product, wherein the anti-dandruff and anti-itching composition is added to the hair washing or hair care product as the sole active ingredient;

[0030] The anti-dandruff and anti-itching composition is prepared by mixing Artemisia annua extract, Lysimachia foenum-graecum extract, Sophora flavescens extract, Schizonepeta tenuifolia extract, Saposhnikovia divaricata extract, and Gypsophila paniculata extract in a weight ratio of 2-6:2-5:2-6:4-6:4-6:2-6 (such as 2:2:2:4:4:2, 6:5:6:6:6:6, 5:3:2:5:5:3, 4:4:2:5:5:3, 5:4:5:6:6:2, 5:4:5:6:6:6, or 6:3:2:6:6:3).

[0031] Preferably, the anti-dandruff and anti-itching composition is prepared by mixing Artemisia annua extract, Lysimachia foenum-graecum extract, Sophora flavescens extract, Schizonepeta tenuifolia extract, Saposhnikovia divaricata extract, and Gypsophila paniculata extract in a weight ratio of 5:4:5:6:6:6.

[0032] Preferably, the weight percentage of the anti-dandruff and anti-itching composition added to the hair washing or hair care product is 0.1%-5.0% (such as 0.1%, 0.2%, 0.5%, 1%, 3%, or 5%).

[0033] Preferably, the Artemisia annua extract is an ethanol extract; and / or the Lysimachia foenum-graecum extract is an ethanol extract; and / or the Sophora flavescens extract is an ethanol extract; and / or the Schizonepeta tenuifolia extract is an ethanol extract; and / or the Saposhnikovia divaricata extract is an ethanol extract; and / or the Gypsophila paniculata extract is an ethanol extract.

[0034] Preferably, the preparation process of the Artemisia annua extract includes: cold extraction with an ethanol aqueous solution 2-3 times, vacuum concentration, extraction, decolorization, filtration, crystallization, and drying.

[0035] Preferably, the weight of the Artemisia annua extract is calculated based on its weight concentrated to 1 / 2 to 1 (such as 1 / 2, 2 / 3, 4 / 5 or 1) of the weight of the original drug; and / or the weight of the Lysimachia foenum-graecum extract is calculated based on its weight concentrated to 1 / 2 to 1 (such as 1 / 2, 2 / 3, 4 / 5 or 1) of the weight of the original drug; and / or the weight of the Sophora flavescens extract is calculated based on its weight concentrated to 1 / 2 to 1 (such as 1 / 2, 2 / 3, 4 / 5 or 1) of the weight of the original drug; and / or the weight of the Schizonepeta tenuifolia extract is calculated based on its weight concentrated to 1 / 2 to 1 (such as 1 / 2, 2 / 3, 4 / 5 or 1) of the weight of the original drug; and / or the weight of the Saposhnikovia divaricata extract is calculated based on its weight concentrated to 1 / 2 to 1 (such as 1 / 2, 2 / 3, 4 / 5 or 1) of the weight of the original drug; and / or the weight of the Gypsophila paniculata extract is calculated based on its weight concentrated to 1 / 2 to 1 (such as 1 / 2, 2 / 3, 4 / 5 or 1) of the weight of the original drug.

[0036] Preferably, the hair washing product is shampoo, hair cream or hair soap.

[0037] Preferably, the hair care product is hair conditioner, hair mask or hair essential oil.

[0038] For the Lysimachia foenum-graecum extract, Sophora flavescens extract, Schizonepeta tenuifolia extract, Saposhnikovia divaricata extract and Gypsophila paniculata extract, the present invention provides a preferred preparation method: the corresponding original medicinal materials of the Lysimachia foenum-graecum extract, Sophora flavescens extract, Schizonepeta tenuifolia extract, Saposhnikovia divaricata extract and Gypsophila paniculata extract are respectively crushed, and extracted by heating under reflux 1 to 3 times with an ethanol solution with a weight volume fraction of 75% to 99% (such as 75%, 80%, 90% or 95%) at 6 to 10 times (such as 6 times, 8 times or 10 times) the weight, and then concentrated under reduced pressure to 0.5 to 1 times the weight of the original medicinal materials.

[0039] For the Artemisia annua extract, the present invention provides a preferred preparation method: the original medicinal materials of Artemisia annua are crushed, extracted and concentrated with an ethanol solution with a volume fraction of 95% to 99%, extracted, decolorized, filtered, crystallized and dried to obtain the Artemisia annua extract, and the purity of the Artemisia annua extract is ≥98%.

[0040] The present invention will be further described by way of examples below, but the protection scope of the present invention is not limited to these embodiments.

[0041] In this example, the preparation methods of Lysimachia foenum-graecum Hance extract, Sophora flavescens Ait. extract, Schizonepeta tenuifolia Briq. extract, Saposhnikovia divaricata (Turcz.) Schischk. extract, and Gypsophila paniculata L. extract are as follows: respectively take the corresponding raw medicinal materials, crush them, heat and reflux extract them with 10 times the weight-volume fraction of 75% ethanol for 3 h, extract 3 times, and then concentrate under reduced pressure to 0.5 times the mass of the raw medicinal materials. The preparation method of Artemisia annua L. extract is as follows: crush the dried branches and leaves of Artemisia annua L., stir and cold-extract them with 10 times the volume fraction of 95% ethanol for 2 h, extract 3 times, then concentrate under reduced pressure to 0.5 times the mass of the raw medicinal materials, continuously extract with solvents such as ethyl acetate, decolorize with activated carbon, filter, then cool and crystallize, recrystallize, and dry to obtain Artemisia annua L. extract.

[0042] The anti-dandruff and antipruritic composition is Artemisia annua L. extract, Lysimachia foenum-graecum Hance extract, Sophora flavescens Ait. extract, Schizonepeta tenuifolia Briq. extract, Saposhnikovia divaricata (Turcz.) Schischk. extract, and Gypsophila paniculata L. extract.

[0043] I. Test on the anti-dandruff and antipruritic effects of the anti-dandruff and antipruritic composition

[0044] 1.1 Test on the anti-dandruff effect of the anti-dandruff and antipruritic composition

[0045] The problem of dandruff is a large amount of desquamation caused by excessive proliferation of scalp keratinocytes. Among them, Malassezia is one of the important factors causing dandruff. The increase in dandruff is a mild manifestation of seborrheic dermatitis of the scalp. Due to the proliferation of Malassezia, the scalp becomes oily and the dandruff is severe, and this situation in turn promotes the proliferation of Malassezia. Therefore, adding an anti-dandruff agent to inhibit or kill such microorganisms has a positive effect on inhibiting the growth of dandruff; using Malassezia as the indicator bacterium, the anti-dandruff effect of hair washing products is tested and evaluated. This test method is an in vitro method and is applicable to the evaluation method of the efficacy of dandruff-claiming cosmetics. The correlation between the detection items and the efficacy claims: This method is an in vitro method. Relevant literature shows that the trend of the in vivo method is basically the same as the results of this in vitro method, and the two methods have a certain correlation. Through experimental design, the higher the inhibitory rate value of Malassezia furfur, the stronger the anti-dandruff efficacy of the sample.

[0046] Take the 24-hour fresh slant culture of the test bacteria, wash it off with 0.03 mol / L phosphate buffer solution (PBS), and dilute it with PBS to a bacterial suspension of about 5.0×105 CFU / mL - 4.5×106 CFU / mL for standby. Take a sterile test tube, first add 5.0 mL of the sample (use the stock solution or dilute it proportionally with distilled water according to the requirements of the instruction manual), place it in a water bath at 20°C ± 1°C for 5 minutes, then add 0.1 mL of the test bacterial suspension, mix quickly and start timing immediately. When the test bacteria and the sample interact for the specified time in the instruction manual, respectively pipette 1.0 mL of the test bacteria and sample mixture and inoculate 2 petri dishes, and pour the culture medium. When the number of bacteria cannot be counted, make 10-fold serial dilutions with PBS, select appropriate dilution degrees, respectively pipette 1.0 mL and inoculate 2 petri dishes for viable bacteria culture and counting. At the same time, use PBS instead of the sample for parallel tests as the positive control. The number of recovered colonies in the positive control is between 1.0×104 CFU / mL - 9.0×104 CFU / mL. Take the same batch of PBS and culture medium as the negative control. All test samples and control samples are cultured at 36°C ± 1°C. Observe the final results after culturing the bacterial vegetative form for 48 hours; observe the final results after culturing Malassezia furfur for 72 hours. Repeat the test 3 times and calculate the antibacterial rate.

[0047] Calculate the antibacterial rate:

[0048]

[0049] In the formula:

[0050] X - antibacterial rate, %;

[0051] A0 - the amount of recovered bacteria in the positive control group, in CFU / mL;

[0052] A1 - the amount of recovered bacteria in the test group, in CFU / mL.

[0053] Table 1 Composition of the anti-dandruff composition

[0054]

[0055] Table 2 Antibacterial effect test of 6 components and mixed components (antibacterial rate against Malassezia furfur, %)

[0056]

[0057] 1.2 Anti-dandruff and antipruritic composition antipruritic efficacy test 220 healthy Hartley guinea pigs weighing 250 - 400 g were selected and randomly divided into 22 groups evenly. There were a blank control group (distilled water 0.1 ml / 100 g), a lotion group (positive control group, Sanwei Qingre Zhiyang Lotion 0.1 ml / 100 g), and 20 sample groups (anti-dandruff and antipruritic composition, samples and concentrations are shown in Table 3) with 0.1 ml / 100 g. Two days before the experiment, the hair on the right hind foot dorsum of each group of Hartley guinea pigs was shaved, and the corresponding experimental test substances were applied externally to the shaved area of each group of animals once a day for 2 consecutive days; on the 3rd day, on the experimental day, the shaved area of the right hind foot dorsum of each group of animals was scratched with coarse sandpaper to damage the epidermis until mild skin bleeding occurred, with an area of 1 cm². Then, the corresponding experimental test substances were applied externally locally to each group of animals once again. 10 minutes after the last application of the experimental test substance, 0.05 ml / animal of 0.01% histamine phosphate solution was dropped on the wound surface. After that, every 3 minutes, the concentration was increased in increments of 0.02%, 0.03%, 0.04%..., and each time it was 0.05 ml / animal until the Hartley guinea pig turned back to lick its right hind foot. The total amount of histamine phosphate (μg) given when the Hartley guinea pig finally turned back to lick its right hind foot was used as the itching threshold, and the itching threshold data of each group were recorded. The higher the itching threshold, the better the antipruritic effect.

[0058] Table 3 Anti-itching effect test of 6 components and mixed components (itching threshold (total amount of histamine phosphate, μg))

[0059]

[0060] II. Anti-dandruff and antipruritic test of shampoo and hair care essence

[0061] 2.1 Preparation of anti-dandruff and antipruritic shampoo: The above-mentioned No. 4 anti-dandruff and antipruritic composition was applied to the shampoo.

[0062] Examples 1 to 4 are the raw materials and weight percentage contents for formulating the shampoo, as shown in Table 4:

[0063] Table 4 Anti-dandruff and antipruritic shampoo formula

[0064]

[0065] 2.2 Preparation of anti-dandruff and antipruritic hair care essence: The above-mentioned No. 4 anti-dandruff and antipruritic composition was applied to the hair care essence.

[0066] Examples 5 to 8 are the raw materials and weight percentage contents for formulating the anti-dandruff and antipruritic hair care essence, as shown in Table 5.

[0067] Table 5 Anti-dandruff and antipruritic hair care essence formula

[0068]

[0069] 2.3 Dandruff-removing and itching-relieving shampoo dandruff-removing and itching-relieving test

[0070] The test method for the dandruff-removing efficacy of the dandruff-removing and itching-relieving shampoo is the same as that of the dandruff-removing and itching-relieving composition. The dandruff-removing effect of the dandruff-removing and itching-relieving shampoo is shown in Table 6.

[0071] Table 6 Inhibitory rate of Malassezia furfur in shampoo

[0072] Example 1 Example 2 Example 3 Example 4 Inhibition rate (%) 59.22 63.27 74.34 89.58

[0073] The test results prove that: the shampoo of this embodiment can significantly inhibit Malassezia furfur, has a dandruff-removing effect, and the more the addition amount of the 4# dandruff-removing and itching-relieving composition, the better the dandruff-removing effect.

[0074] The test method for the itching-relieving efficacy of the dandruff-removing and itching-relieving shampoo is the same as that of the dandruff-removing and itching-relieving composition. The itching-relieving effect of the dandruff-removing and itching-relieving shampoo is shown in Table 7.

[0075] Table 7 Itching-relieving effect test of dandruff-removing and itching-relieving shampoo (itching threshold (total amount of histamine phosphate, μg))

[0076]

[0077] The test results prove that: Examples 2 and 4 can significantly increase the itching threshold of histamine phosphate in guinea pigs, indicating that both Example 2 and Example 4 have obvious itching-relieving effects, and the more the addition amount of the 4# dandruff-removing and itching-relieving composition, the more obvious the itching-relieving effect.

[0078] 2.4 Dandruff-removing and itching-relieving hair care essence dandruff-removing and itching-relieving test

[0079] The test method for the dandruff-removing efficacy of the dandruff-removing and itching-relieving hair care essence is the same as that of the dandruff-removing and itching-relieving composition. The dandruff-removing effect of the dandruff-removing and itching-relieving hair care essence is shown in Table 8.

[0080] Table 8 Inhibitory rate of Malassezia furfur in hair care essence

[0081] Example 5 Example 6 Example 7 Example 8 Inhibition rate (%) 32 39 41 49

[0082] The test results prove that: the shampoo of this embodiment can significantly inhibit Malassezia furfur, has a dandruff-removing effect, and the more the addition amount of the 4# dandruff-removing and itching-relieving composition, the better the dandruff-removing effect.

[0083] The test method for the itching-relieving efficacy of the dandruff-removing and itching-relieving hair care essence is the same as that of the dandruff-removing and itching-relieving composition. The itching-relieving effect of the hair care essence is shown in Table 9.

[0084] Table 9 Itching-relieving effect test of hair care essence (itching threshold (total amount of histamine phosphate, μg))

[0085]

[0086]

[0087] The test results prove that: both Example 6 and Example 8 can significantly increase the itching threshold of histamine phosphate in guinea pigs, indicating that both Example 6 and Example 8 have obvious antipruritic effects, and the more the addition amount of the 4# anti-dandruff and antipruritic composition, the more obvious the antipruritic effect.

Claims

1. Use of an anti-dandruff and anti-itch composition in the preparation of a hair washing or hair care product, characterized in that, the anti-dandruff and anti-itch composition is added to the hair washing or hair care product as the sole active ingredient; the anti-dandruff and anti-itch composition is prepared by mixing Artemisia annua extract, Lysimachia foenum-graecum extract, Sophora flavescens extract, Schizonepeta tenuifolia extract, Saposhnikovia divaricata extract and Gypsophila paniculata extract in a weight ratio of 2-6:2-5:2-6:4-6:4-6:2-6.

2. Use of the anti-dandruff and anti-itch composition according to claim 1 in the preparation of a hair washing or hair care product, characterized in that, the anti-dandruff and anti-itch composition is prepared by mixing Artemisia annua extract, Lysimachia foenum-graecum extract, Sophora flavescens extract, Schizonepeta tenuifolia extract, Saposhnikovia divaricata extract and Gypsophila paniculata extract in a weight ratio of 5:4:5:6:6:

6.

3. Use of the anti-dandruff and anti-itch composition according to claim 1 in the preparation of a hair washing or hair care product, characterized in that, the weight percentage of the anti-dandruff and anti-itch composition added to the hair washing or hair care product is 0.1%-5.0%.

4. Use of the anti-dandruff and anti-itch composition according to claim 1 in the preparation of a hair washing or hair care product, characterized in that, the Artemisia annua extract is an ethanol extract; and / or the Lysimachia foenum-graecum extract is an ethanol extract; and / or the Sophora flavescens extract is an ethanol extract; and / or the Schizonepeta tenuifolia extract is an ethanol extract; and / or the Saposhnikovia divaricata extract is an ethanol extract; and / or the Gypsophila paniculata extract is an ethanol extract.

5. Use of the anti-dandruff and anti-itch composition according to claim 4 in the preparation of a hair washing or hair care product, characterized in that, the preparation process of the Artemisia annua extract includes: cold extraction with ethanol aqueous solution for 2-3 times, vacuum concentration, extraction, decolorization, filtration, crystallization, drying.

6. Use of the anti-dandruff and anti-itch composition according to claim 1 in the preparation of a hair washing or hair care product, characterized in that, the weight of the Artemisia annua extract is calculated based on its weight concentrated to 1 / 2-1 of the original drug weight; and / or the weight of the Lysimachia foenum-graecum extract is calculated based on its weight concentrated to 1 / 2-1 of the original drug weight; and / or the weight of the Sophora flavescens extract is calculated based on its weight concentrated to 1 / 2-1 of the original drug weight; and / or the weight of the Schizonepeta tenuifolia extract is calculated based on its weight concentrated to 1 / 2-1 of the original drug weight; and / or the weight of the Saposhnikovia divaricata extract is calculated based on its weight concentrated to 1 / 2-1 of the original drug weight; and / or the weight of the Gypsophila paniculata extract is calculated based on its weight concentrated to 1 / 2-1 of the original drug weight.

7. Use of the anti-dandruff and anti-itch composition according to claim 1 in the preparation of a hair washing or hair care product, characterized in that, the hair washing product is shampoo, hair cream or hair soap.

8. Use of the anti-dandruff and anti-itch composition according to claim 1 in the preparation of a hair washing or hair care product, characterized in that, the hair care product is shampoo, hair conditioner, hair mask or hair essence.

Citation Information

Patent Citations

  • Mould-proof bacteriostatic Chinese medicinal detergent

    CN102978024A

  • Biological anti-dandruff and itch-relieving compound and application thereof

    CN109568219A

  • Anti-dandruff and itching-relieving composition and application thereof

    CN111973530A

  • Amino acid shampoo with oil control and dandruff removal effects and preparation method thereof

    CN112274439A

  • Anti-dandruff and antipruritic composition, preparation method and application thereof, shampoo and preparation method thereof

    CN115813841A