Noninvasive intracranial pressure measuring device based on hydrophone and working method of noninvasive intracranial pressure measuring device

Abstract

The invention provides a non-invasive intracranial pressure measuring device based on a hydrophone and a working method thereof.The measuring device comprises a shell with an opening in one end, the shell is filled with liquid, and the opening end of the shell is sealed through an ultrasonic reinforcing material; a hydrophone fixed through a fixing end is arranged in the shell, an electric signal transmission end of the hydrophone is connected with an ultrasonic device outside the shell through a wire connector, and an ultrasonic transmission end of the hydrophone faces an opening of the shell. In order to solve the problems of low transmission precision and low sensitivity of a signal generating device in the intracranial pressure bionic measurement process, a hydrophone in a liquid environment is used for replacing a traditional signal generating and receiving device to transmit and receive ultrasonic waves; the transmission accuracy and sensitivity of signal generating and receiving devices in an intracranial pressure measurement experiment are improved, so that the accuracy of intracranial pressure measurement is ensured.

Description

Technical Field

[0001] The present invention relates to the technical field of intracranial pressure monitoring, and specifically to a non-invasive intracranial pressure measurement device based on a hydrophone and its working method. Background Art

[0002] Intracranial pressure (ICP) refers to the hydrostatic pressure of cerebrospinal fluid surrounding nerve tissue and cerebral blood vessels within the cranial cavity. The average cerebrospinal fluid pressure of normal adults in the supine position is 5 - 15 mmHg (0.7 - 2 kPa). An increase in ICP is one of the severe complications of neurological critical illnesses, which can occur in traumatic brain injury (TBI), stroke, intracranial hemorrhage, intracranial infection, hydrocephalus, brain tumors, and other neurological diseases. An increase in ICP can lead to a disorder of the body's self-regulatory function, followed by irreversible brain damage such as reduced cerebral perfusion pressure, obstruction of venous sinus return, secondary brain herniation, and brainstem injury, and can even cause the death of the patient.

[0003] Currently, invasive intracranial pressure monitoring methods are recognized as the gold standard. They mainly include lumbar puncture manometry and craniotomy manometry. However, these methods not only have high costs but also cause damage to brain tissue, are prone to causing numerous complications, and increase the pain of patients. Therefore, finding non-invasive and accurate monitoring methods has become an urgent need in clinical medicine.

[0004] In the past few decades, numerous non-invasive intracranial pressure monitoring methods have emerged, such as transcranial Doppler (TCD), otoacoustic emissions (OAE), retinal vein pressure (RVP), optic nerve sheath diameter (ONSD), etc. Although these methods have achieved non-invasiveness, they have not been substantially promoted because they either cannot monitor in real time, are significantly affected by individual differences, or the instrument cost is expensive.

[0005] A Chinese patent with the application number 2024114241929 previously applied by the applicant discloses a non-invasive intracranial pressure monitoring experimental device and method. In this application, the ultrasonic wave emitted by the ultrasonic signal generator is converted into mechanical vibration by the ultrasonic transmitter, and mechanical waves are emitted to the variable pressure bladder and the intracranial pressure bionic experimental module. The variable pressure bladder generates periodic pressure, and the pressure inside the intracranial pressure bionic experimental module changes periodically at the same frequency as the heartbeat. The signal receiver receives the mechanical wave passing through the cranial cavity and converts it into a high-frequency electrical signal, and outputs the high-frequency signal to the signal processor to calculate the value of intracranial pressure. In actual experiments, the applicant found that the signal generating devices on both sides of the intracranial pressure bionic experimental module in this device have problems of low transmission accuracy and low sensitivity and need to be improved. Summary of the Invention

[0006] In order to solve the problems of the prior art, the present invention provides a non-invasive intracranial pressure measurement device based on a hydrophone, which uses a hydrophone in a liquid environment to replace the traditional signal generating and receiving device for transmitting and receiving ultrasonic waves, improving the transmission accuracy and sensitivity of the signal generating and receiving device in the intracranial pressure measurement experiment, thereby ensuring the accuracy of intracranial pressure measurement.

[0007] The present invention provides a non-invasive intracranial pressure measurement device based on a hydrophone, including a housing with an opening at one end, the inside of the housing is filled with liquid, and the opening end of the housing is sealed by an ultrasonic enhancement material; a hydrophone fixed by a fixed end is arranged inside the housing, and the electrical signal transmission end of the hydrophone is connected to an ultrasonic device outside the housing through a wire connector, and the ultrasonic transmission end of the hydrophone faces the opening of the housing.

[0008] The outer end of the ultrasonic enhancement material is coated with a bio-gel.

[0009] The present invention also provides a working method of a non-invasive intracranial pressure measurement device based on a hydrophone, including the following steps: 1) Connect two non-invasive intracranial pressure measurement devices based on hydrophones by a connector, so that the two non-invasive intracranial pressure measurement devices based on hydrophones are on the same horizontal plane; 2) Make one non-invasive intracranial pressure measurement device based on a hydrophone as a signal transmitting end, its wire connector is connected to an ultrasonic transmitting device, make the other non-invasive intracranial pressure measurement device based on a hydrophone as a signal receiving end, its wire connector is connected to an ultrasonic signal receiving device, and make the two non-invasive intracranial pressure measurement devices based on hydrophones adhere to both sides of the intracranial pressure bionic experiment module through bio-gel; 3) The ultrasonic transmitting device emits ultrasonic waves, the hydrophone of the signal transmitting end emits ultrasonic waves to the intracranial pressure bionic experiment module in the liquid environment, the hydrophone of the signal receiving end receives the ultrasonic waves passing through the intracranial pressure bionic experiment module in the liquid environment and then sends them to the ultrasonic signal receiving device, and the ultrasonic signal receiving device converts the ultrasonic waves into electrical signals and analyzes them.

[0010] The beneficial effects of the present invention are as follows: 1. The hydrophone is used to replace the traditional signal generating and receiving device for transmitting and receiving ultrasonic waves, and by using the characteristics that the sound attenuation coefficient of ultrasonic waves in a liquid is significantly smaller than that in air, and the sensitivity of the hydrophone in water is higher than that in air, the hydrophone is in a liquid environment in engineering applications, enhancing the sensitivity.

[0011] 2. The ultrasonic enhancement material is fixed at the opening of the rigid housing, which not only screens the ultrasonic waves in the required direction but also effectively enhances the penetration characteristics of the ultrasonic waves.

[0012] 3. The biogel enables the entire device to fit better with the experimental end, improving the comfort and operability of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0014] Figure 1 It is a schematic structural diagram of the present invention.

[0015] Figure 2 It is a schematic structural diagram of the application scenario of the present invention.

[0016] Figure 3 It is a schematic diagram of the equipment in the application scenario of the present invention.

[0017] Figure 4 It is a schematic diagram of the hydrophone reading in the water environment.

[0018] Figure 5 It is a schematic diagram of the hydrophone reading in the air. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0019] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of the present invention.

[0020] The present invention provides a non-invasive intracranial pressure measurement device based on a hydrophone, as Figure 1 shown, which includes a housing with an opening at one end. The housing is filled with liquid inside, and the opening end of the housing is sealed by an ultrasonic enhancement material; a hydrophone fixed through a fixed end is arranged inside the housing. The electrical signal transmission end of the hydrophone is connected to an ultrasonic device outside the housing through a wire connector, and the ultrasonic transmission end of the hydrophone faces the opening of the housing.

[0021] The outer end of the ultrasonic enhancement material is coated with a biogel.

[0022] The present invention also provides a working method for a non-invasive intracranial pressure measurement device based on a hydrophone, including the following steps: 1) As Figure 2 and Figure 3As shown in the figure, two hydrophone-based non-invasive intracranial pressure measurement devices are connected by a connecting piece 5, so that the two hydrophone-based non-invasive intracranial pressure measurement devices are on the same horizontal plane.

[0023] 2) Use one hydrophone-based non-invasive intracranial pressure measurement device as the signal transmitting end 2, and connect its wire connector to the ultrasonic transmitting device 1. Use the other hydrophone-based non-invasive intracranial pressure measurement device as the signal receiving end 4, and connect its wire connector to the ultrasonic signal receiving device. Then, adhere the two hydrophone-based non-invasive intracranial pressure measurement devices to both sides of the intracranial pressure bionic experiment module through the biological gel 3. The ultrasonic signal receiving device includes a signal circuit module 6 and a signal processing module 7.

[0024] 3) The ultrasonic transmitting device emits ultrasonic waves. The hydrophone at the signal transmitting end emits ultrasonic waves to the intracranial pressure bionic experiment module in the liquid environment. The hydrophone at the signal receiving end receives the ultrasonic waves passing through the intracranial pressure bionic experiment module in the liquid environment and then sends them to the ultrasonic signal receiving device. The ultrasonic signal receiving device converts the ultrasonic waves into electrical signals and analyzes them.

[0025] Device Effect Verification The liquid component in the rigid shell utilizes the characteristic that the sensitivity of the hydrophone in water is higher than that in air, so that the hydrophone is in a liquid environment in engineering applications, enhancing the sensitivity. (Principle: Since the expression of the sound attenuation rate is: , h2 is the amplitude of the signal received by the signal acquisition device, h1 is the amplitude of the emitted signal, and d is the transmission distance. In order to improve the signal acquisition accuracy and the ultrasonic propagation distance, we need a lower sound attenuation rate. And the sound attenuation rate is closely related to the type of medium. Under normal temperature conditions, the attenuation rate of 1MHz ultrasonic waves in air is 1.6dB / cm, and in water is 0.016dB / cm. Therefore, using water as the ultrasonic propagation medium can effectively reduce the sound attenuation rate, increase the signal transmission distance and transmission amplitude, and thus improve the measurement accuracy). As Figure 4 and Figure 5 shown, when the amplitude, frequency and other indicators of the ultrasonic waves emitted by the signal generating device are exactly the same, the readings of the same hydrophone in water are significantly higher than those of the hydrophone in air.

[0026] Each embodiment in this specification is described in a progressive manner. For the same or similar parts among the embodiments, reference can be made to each other. Each embodiment focuses on the differences from other embodiments. In particular, for the device embodiments, the above description is only the preferred implementation manner of the present invention. Since it is basically similar to the method embodiments, the description is relatively simple. For the relevant parts, reference can be made to the partial description of the method embodiments. As mentioned above, the above is only the specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. For any person skilled in the art in the technical field disclosed by the present invention, for those of ordinary skill in the technical field, any changes or substitutions that can be easily thought of without departing from the principle of the present invention should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be subject to the protection scope of the claims.

Claims

1. A non-invasive intracranial pressure measurement device based on a hydrophone, characterized in that: It includes a housing with an opening at one end. The interior of the housing is filled with liquid, and the opening end of the housing is sealed by an ultrasonic enhancement material. A hydrophone fixed by a fixed end is arranged inside the housing. The electrical signal transmission end of the hydrophone is connected to an ultrasonic device outside the housing through a wire connector, and the ultrasonic transmission end of the hydrophone faces the opening of the housing.

2. The non-invasive intracranial pressure measurement device based on a hydrophone according to claim 1, characterized in that: The outer end of the ultrasonic enhancement material is coated with a biogel.

3. The working method of a non-invasive intracranial pressure measurement device based on a hydrophone, characterized in that It includes the following steps: 1) Connect two non-invasive intracranial pressure measurement devices based on hydrophones described in claim 1 using a connector, so that the two non-invasive intracranial pressure measurement devices based on hydrophones are on the same horizontal plane. 2) Use one non-invasive intracranial pressure measurement device based on a hydrophone as a signal transmitter, whose wire connector is connected to an ultrasonic transmitter. Use the other non-invasive intracranial pressure measurement device based on a hydrophone as a signal receiver, whose wire connector is connected to an ultrasonic signal receiver, and adhesively bond the two non-invasive intracranial pressure measurement devices based on hydrophones to both sides of the intracranial pressure bionic experimental module through a biogel. 3) The ultrasonic transmitter emits ultrasonic waves. The hydrophone at the signal transmitter emits ultrasonic waves to the intracranial pressure bionic experimental module in a liquid environment. The hydrophone at the signal receiver receives the ultrasonic waves passing through the intracranial pressure bionic experimental module in a liquid environment and then sends them to the ultrasonic signal receiver. The ultrasonic signal receiver converts the ultrasonic waves into electrical signals and analyzes them.

Images