Rib bone fracture plate, preparation method of rib bone fracture plate and preparation method of bone fracture plate matrix

Abstract

The invention provides a rib bone fracture plate and a preparation method of the rib bone fracture plate, and provides a preparation method of a bone fracture plate matrix. And the rib bone fracture plate is used for connecting the fractured left bone and the fractured right bone. The rib bone fracture plate comprises a connecting part, a columnar part, a fixing part and a plurality of abutting beards. The columnar part is connected with the first end of the connecting part, and the fixing part is connected with the second end of the connecting part. And the propping part needs to be fixed on the side wall of the columnar part. The connecting part is located in a marrow cavity of the fractured left bone and a marrow cavity of the fractured right bone, the abutting part needs to abut against the inner wall of the marrow cavity of the fractured left bone, a gap exists between the columnar part and the inner wall of the marrow cavity, and the fixing part is connected with the fractured right bone. According to the rib bone fracture plate, through the arrangement of the abutting beards, the rib bone fracture plate is not prone to large deformation, lateral displacement of the rib fracture end caused by breathing of the human body is not prone to occurring, and meanwhile the operative wound of the rib bone fracture plate is small.

Description

Technical Field

[0001] The present invention relates to the field of medical devices, and particularly to a rib plate, a preparation method of the rib plate, and a preparation method of a plate substrate. Background Art

[0002] When a human rib bone is fractured, a bone plate is often used to connect the fractured bones together.

[0003] At present, the bone plates used clinically are mainly divided into two fixation methods: external fixation and intramedullary fixation. The external fixation bone plate is installed on the outer surface of the bone, while the intramedullary fixation bone plate is implanted into the bone marrow cavity for fixation. From the perspective of biomechanics, the intramedullary fixation bone plate is closer to the mechanical neutral axis of the bone due to its position. When dealing with mechanical loads such as bending and torsion, the stress it bears is significantly less than that of the external fixation bone plate placed on the bone surface. This design advantage makes the intramedullary fixation system perform better in terms of mechanical stability.

[0004] However, most of the existing intramedullary fixation bone plates adopt a two - end fixation method. First, the intramedullary nail is implanted into the bone marrow cavity by the intramedullary nail fixation method, and then the two ends of the bone plate are fixed to both ends of the bone fracture with fixing nails. However, when the existing intramedullary fixation bone plate is used on the rib, the rib will also move with the breathing of the human body. Since there is a gap between the bone plate body and the inner wall of the bone marrow cavity, the bone plate body will also move in the radial direction of the bone marrow cavity, and the bone plate body is prone to large deformation, ultimately resulting in lateral displacement of the rib fracture end. At the same time, since both ends of the existing intramedullary fixation bone plate need to be fixed with fixing nails, the surgical wound is relatively large. Summary of the Invention

[0005] Aiming at the problems existing in the above - mentioned prior art, the present invention discloses a rib plate, a preparation method of the rib plate, and a preparation method of a plate substrate, in which the rib fracture end is not prone to lateral displacement, and the surgical wound is relatively small.

[0006] The object of the present invention is achieved by the following technical solutions: The present invention provides a rib plate for connecting a fractured left bone and a fractured right bone, including a connecting portion, a columnar portion, a fixing portion, and a plurality of abutting whiskers; the columnar portion is connected to the first end of the connecting portion, and the fixing portion is connected to the second end of the connecting portion; the abutting whiskers are fixed on the side wall of the columnar portion; the connecting portion is located in the bone marrow cavities of the fractured left bone and the fractured right bone, the abutting whiskers abut against the inner wall of the bone marrow cavity of the fractured left bone, and there is a gap between the columnar portion and the inner wall of the bone marrow cavity, and the fixing portion is connected to the fractured right bone.

[0007] Further, it further includes a plurality of relief whiskers disposed on the columnar portion, all of the relief whiskers are disposed on a side of the abutting whisker away from the connecting portion, and there is a gap between the relief whisker and the inner wall of the bone marrow cavity; there is a gap between each of the relief whiskers for accommodating bone debris in the bone marrow cavity.

[0008] Further, there is a gap between each of the abutting whiskers for accommodating bone debris in the bone marrow cavity.

[0009] Further, the abutting whisker includes a hydrogel layer, and the hydrogel layer forms the outer surface of the abutting whisker; after the hydrogel layer absorbs body fluid and swells, the contact area between the abutting whisker and the inner wall of the bone marrow cavity increases.

[0010] Further, the connecting portion, the columnar portion, the fixing portion and the abutting whisker are all made of degradable materials.

[0011] Further, a guiding portion for opening a path is provided at one end of the columnar portion away from the connecting portion.

[0012] Further, a surgical hole is provided on the side wall of the fractured right bone, the columnar portion, the abutting whisker and the connecting portion pass through the surgical hole and enter the bone marrow cavity, and the fixing portion is fixed on the outer wall of the fractured right bone.

[0013] Still further, one end of each of the abutting whisker and the relief whisker is connected to the side wall of the columnar portion, and the other end of the abutting whisker abuts against the inner wall of the bone marrow cavity of the fractured left bone; both the abutting whisker and the relief whisker are inclined toward the connecting portion side.

[0014] Still further, reinforcing ribs are provided in the connecting portion, the columnar portion and the fixing portion, and the reinforcing ribs are coated with a silk fibroin layer; the reinforcing ribs include magnesium wires and include PCL wires and / or PCLA wires.

[0015] Even further, the PCL wire and / or the PCLA wire is wound around the magnesium wire to braid and form the reinforcing rib.

[0016] Even further, at least two reinforcing ribs are provided; each of the reinforcing ribs is arranged in parallel or each of the reinforcing ribs is arranged in a cross pattern.

[0017] Still further, the abutting whisker further includes a silk fibroin core, and the hydrogel layer coats the silk fibroin core.

[0018] The present invention also provides a method for preparing a rib osteosynthesis plate for preparing a rib osteosynthesis plate with a silk fibroin core in the abutting whisker, including the following steps: Step 1, provide an osteosynthesis plate substrate, and the osteosynthesis plate substrate includes a columnar portion, a connecting portion and a fixing portion connected in sequence; Step 2: Mix the silk fibroin solution and the silver nanowire solution to form a first mixed solution; Step 3: Use the first mixed solution to prepare a silk fibroin core, and one end of the silk fibroin core is connected to the columnar part; Step 4: Mix the silk fibroin solution, gelatin, polypyrrole monomer, ferric chloride, glycerol and chitosan to form a second mixed solution; Step 5: Immerse the silk fibroin core in the second mixed solution, and form a hydrogel layer on the silk fibroin core through an electrochemical reaction, so as to obtain the supporting whisker.

[0019] In addition, the present invention provides a preparation method of a bone plate matrix for preparing the bone plate matrix, including the following steps. Step 1: Mix and braid PCL filaments and / or PCLA filaments with magnesium filaments to form a reinforcing rib; Step 2: Place the reinforcing rib in a casting container, and both ends of the reinforcing rib are respectively fixed on the side wall of the casting container; Step 3: Inject the silk fibroin solution into the casting container, and the reinforcing rib is immersed in the silk fibroin solution. After casting, a bone plate embryo is obtained; Step 4: Perform a subtractive manufacturing process on the bone plate embryo to process and form the bone plate matrix.

[0020] Compared with the prior art, the beneficial effects of the present invention are as follows: Through the setting of the supporting whisker, one end of the bone plate is equivalent to being movably connected to the bone marrow cavity. During the reciprocating movement of the rib caused by human breathing, the bone plate reciprocates along the axis of the bone marrow cavity in the bone marrow cavity. The rib bone plate of the present invention is not prone to large deformation. And because the supporting whisker abuts against the inner wall of the bone marrow cavity, it is equivalent that there is no gap between one end of the rib bone plate and the inner wall of the bone marrow cavity. Therefore, the rib bone plate of the present invention is not prone to lateral displacement of the rib fracture end caused by human breathing. In addition, only one end of the rib bone plate of the present invention is fixedly connected to the rib, and the surgical wound is small. Description of the Drawings

[0021] Figure 1 is a schematic diagram of a traditional intramedullary fixation bone plate in the bone marrow cavity of a fractured rib; Figure 2 is a schematic diagram of the rib bone plate of the present invention in the bone marrow cavity of a fractured rib; Figure 3 is a three-dimensional view of the rib bone plate of the present invention; Figure 4 is a top view of the rib bone plate of the present invention; Figure 5 is a front view of the rib bone plate of the present invention; Figure 6It is a perspective view of the bone plate base body of the present invention; Figure 7 It is a perspective view of the reinforcing rib of the present invention; Figure 8 It is a schematic diagram of the reinforcing rib in the casting container of the present invention; Figure 9 It is a schematic diagram of the parallel arranged reinforcing ribs in the present invention; Figure 10 It is a schematic diagram of the cross-arranged reinforcing ribs in the present invention.

[0022] In the figure: 1a - fractured left bone; 1b - fractured right bone; 2 - connecting part; 3 - columnar part; 4 - fixing part; 5 - abutting whisker; 6 - relieving whisker; 7 - guiding part; 8 - reinforcing rib; 8a - magnesium wire; 8b - PCL wire; 8c - PCLA wire; 9 - casting container; 10 - bone plate body; 11 - through screw; 12 - fixing screw. Detailed implementation manners

[0023] Next, the technical solutions of the present invention will be clearly and completely described in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of them. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0024] In the description of the present invention, it should be noted that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation to the present invention. In addition, the terms "first", "second", "third" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0025] In the description of the present invention, it should be noted that unless otherwise clearly specified and limited, the terms "installed", "connected", "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations. In addition, the technical features involved in different embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other.

[0026] Traditional intramedullary fixation plates, such as Figure 1 shown, the plate body 10 of the plate is implanted into the bone marrow cavity of the fractured rib. The bones on the left and right sides of the crack of the fractured rib are respectively defined as the fractured left bone 1a and the fractured right bone 1b. The first end of the plate body 10 is located in the bone marrow cavity of the fractured left bone 1a, and the first end of the plate body 10 is fixed to the fractured left bone 1a by a through screw 11. The second end of the plate body 10 is located in the bone marrow cavity of the fractured right bone 1b, and the second end of the plate body 10 is fixed to the fractured right bone 1b by a fixing screw 12. As can be seen from Figure 1 , in order to facilitate the implantation of the plate body 10 into the bone marrow cavity, there is a gap between the first end of the plate body 10 and the inner wall of the rib bone marrow cavity. Therefore, the traditional intramedullary fixation plate has the following several defects: First, when a person breathes, the rib will reciprocate due to the expansion and contraction of the chest cavity, and the plate body 10 will also reciprocate accordingly. The long-term reciprocating movement of the plate body 10 is likely to cause the plate body 10 to deform.

[0027] Second, due to the gap between the plate body 10 and the inner wall of the bone marrow cavity, during the breathing process of the human body, as the rib reciprocates, the plate body 10 will also move in the radial direction of the bone marrow cavity, ultimately resulting in lateral displacement of the fracture ends of the rib, as shown in Figure 1 , a dislocation occurs between the fractured left bone 1a and the fractured right bone 1b.

[0028] Third, since the first end of the plate body 10 is fixed to the fractured left bone 1a by a through screw 11 and the second end of the plate body 10 is fixed to the fractured right bone 1b by a fixing screw 12. Therefore, at least two incisions are required during the process of implanting the plate body 10 into the rib, respectively for fixing the through screw 11 and the fixing screw 12, and the surgical incisions are relatively large.

[0029] In view of the above defects of the traditional intramedullary fixation plate, the present invention discloses a rib plate, which adopts the intramedullary fixation method, as shown in Figure 2 , and is used to connect the fractured left bone 1a and the fractured right bone 1b on the rib.

[0030] As shown in Figures 3 to 5 , the rib plate of the present invention includes a connecting portion 2, a columnar portion 3, a fixing portion 4 and a plurality of abutting whiskers 5. The columnar portion 3 is connected to the first end of the connecting portion 2, and the fixing portion 4 is connected to the second end of the connecting portion 2, that is, the columnar portion 3, the connecting portion 2 and the fixing portion 4 are connected in sequence along the same straight line direction. The abutting whiskers 5 are fixed on the side wall of the columnar portion 3, and the abutting whiskers 5 and the columnar portion 3 form a shape similar to a feather duster. The connecting portion 2 is a flat long strip plate shape, and the connecting portion 2 has relatively high strength and stiffness and is used for connecting the fractured left bone 1a and the fractured right bone 1b.

[0031] As shown Figure 2 When the rib plate of the present invention needs to be implanted onto a fractured rib, a surgical hole communicating with the bone marrow cavity is formed in the fractured right bone 1b. Subsequently, the columnar portion 3 together with the abutting whiskers 5 is driven into the surgical hole. At this time, the abutting whiskers 5 have abutted against the inner wall of the bone marrow cavity of the fractured right bone 1b. The columnar portion 3 is pushed towards the fractured left bone 1a, and the connecting portion 2 also enters the bone marrow cavity of the fractured right bone 1b. The columnar portion 3 together with the abutting whiskers 5 is continuously pushed towards the fractured left bone 1a. When the columnar portion 3 enters the bone marrow cavity of the fractured left bone 1a, the abutting whiskers 5 abut against the inner wall of the bone marrow cavity of the fractured left bone 1a. The columnar portion 3 together with the abutting whiskers 5 is continuously pushed towards the fractured left bone 1a until the connecting portion 2 enters the bone marrow cavity of the fractured left bone 1a. At this time, a part of the connecting portion 2 still remains in the bone marrow cavity of the fractured right bone 1b.

[0032] As shown Figure 2 When the connecting portion 2 is located in the bone marrow cavities of the fractured left bone 1a and the fractured right bone 1b, the columnar portion 3 is located in the bone marrow cavity of the fractured left bone 1a, and the abutting whiskers 5 abut against the inner wall of the bone marrow cavity of the fractured left bone 1a. Due to the frictional force between each abutting whisker 5 and the inner wall of the bone marrow cavity, it is difficult for the abutting whiskers 5 to move, so it is difficult for the columnar portion 3 to move. Due to the existence of the abutting whiskers 5, there is a gap between the columnar portion 3 and the inner wall of the bone marrow cavity. Relatively speaking, the harder columnar portion 3 will not abut against the inner wall of the bone marrow cavity, so the columnar portion 3 will not cause reciprocating rubbing in the bone marrow cavity due to the reciprocating movement of the rib caused by human breathing. Subsequently, the fixing portion 4 is connected to the fractured right bone 1b, and thus the implantation of the rib plate of the present invention is completed.

[0033] The rib plate of the present invention has the following advantages: First, when a person breathes, the rib will reciprocate due to the expansion and contraction of the chest cavity. Since the abutting whiskers 5 are relatively soft and there is no rigid connection between the abutting whiskers 5 and the inner wall of the bone marrow cavity of the fractured left bone 1a. Therefore, even if the rib reciprocates, the columnar portion 3 will only reciprocate along the axis of the bone marrow cavity in the bone marrow cavity of the fractured left bone 1a, so that the deformation of the connecting portion 2 that plays the role of connecting the fractured ribs is relatively small.

[0034] Second, since the abutting whiskers 5 abut against the inner wall of the bone marrow cavity of the fractured left bone 1a. Therefore, it is equivalent that there is no gap between the rib plate of the present invention and the inner wall of the bone marrow cavity of the fractured left bone 1a. Therefore, the rib plate of the present invention is not likely to cause the misalignment as shown Figure 1 between the fractured left bone 1a and the fractured right bone 1b due to human breathing.

[0035] Third, since the rib plate of the present invention only needs to connect the fixing portion 4 to the fractured rib, compared with the design of the conventional intramedullary fixation plate that requires at least two fixing points, the surgical wound of the rib plate of the present invention is smaller.

[0036] In the rib plate of the present invention, there are various implementation manners for the material of the abutting whisker 5, the arrangement of the abutting whisker 5, and many other technical features. In the following, among many technical features such as the material of the abutting whisker 5, one implementation manner is mainly selected for each technical feature for detailed description, and the embodiment where this implementation manner is located is called this embodiment. Other implementation manners of many features such as the material of the abutting whisker 5 are called other embodiments, and a brief description is given for other embodiments below.

[0037] In this embodiment, as Figure 2 and Figure 3 shown, the rib plate of the present invention further includes a plurality of relief whiskers 6 provided on the columnar portion 3. The relief whiskers 6 have elasticity. Each relief whisker 6 is provided on the side of the abutting whisker 5 away from the connecting portion 2. Both the abutting whisker 5 and the relief whisker 6 can be fixed at one end on the columnar portion 3, and the length of the relief whisker 6 is shorter than the length of the abutting whisker 5. It is set that when the rib plate of the present invention is implanted into a fractured rib, there is a gap between each relief whisker 6 and the inner wall of the bone marrow cavity of the fractured left bone 1a. At the same time, it is set that there is a gap for accommodating bone debris in the bone marrow cavity between each relief whisker 6. As Figure 2 shown, each relief whisker 6 can be arranged around the axis of the columnar portion 3, and each relief whisker 6 is arranged in an array, so that bone debris can be caught in the gap between each relief whisker 6.

[0038] In this embodiment, as Figure 2 and Figure 3 shown, after rib fracture, some bone debris generated by the fracture will fall into the bone marrow cavity. Since the abutting whisker 5 abuts against the inner wall of the bone marrow cavity when entering the bone marrow cavity of the fractured right bone 1b. Therefore, the abutting whisker 5 may push the bone debris in the bone marrow cavity of the fractured right bone 1b out of the bone marrow cavity from the rib fracture crack during the movement of the abutting whisker 5 along with the columnar portion 3 towards the fractured left bone 1a, so that the bone debris falls into the thoracic cavity, which may cause damage to human organs. Due to the setting of the relief whisker 6, the relief whisker 6 never contacts the bone marrow cavity during the movement in the bone marrow cavity. Because there are other substances such as red bone marrow in the bone marrow cavity, the bone debris usually adheres to the side wall of the bone marrow cavity. When the abutting whisker 5 contacts the bone debris falling in the bone marrow cavity, the abutting whisker 5 causes the bone debris to fall off from the side wall of the bone marrow cavity, and the fallen bone debris will be caught in the gap between each relief whisker 6. When the abutting whisker 5 continues to move towards the fractured left bone 1a, the relief whisker 6 together with the bone debris moves into the bone marrow cavity of the fractured left bone 1a. Therefore, the present invention greatly reduces the possibility of bone debris falling into the thoracic cavity through the setting of the relief whisker 6. In other embodiments, when it is found through X-ray examination that the bone marrow cavity is relatively clean and there is no bone debris, the relief whisker 6 may not be provided either.

[0039] In this embodiment, as Figure 2 and Figure 3As shown, each abutting whisker 5 is also provided with a gap for accommodating bone debris in the medullary cavity. Each abutting whisker 5 also adopts a scheme of being arranged around the axis of the columnar portion 3, and each abutting whisker 5 is arranged in an array. Therefore, when the abutting whisker 5 moves in the medullary cavity of the broken right bone 1b, part of the bone debris can also be stuck in the gap between each abutting whisker 5, reducing the possibility of bone debris falling into the chest cavity. At the same time, in this embodiment, due to the setting of the yield whisker 6, even if part of the bone debris is not stuck in the gap between each abutting whisker 5, it can still fall into the gap between each yield whisker 6. In other embodiments, when it is found that the medullary cavity is relatively clean and there is no bone debris under X-ray examination, in addition to not setting the yield whisker 6, each abutting whisker 5 can also be arranged in a dispersed arrangement or a dense arrangement, that is, each abutting whisker 5 can adopt a gap that is much larger than the maximum length of the bone debris and a gap that is much smaller than the minimum length of the bone debris. In other embodiments, either of the gaps between the yielding whiskers 6 for accommodating bone fragments in the medullary cavity or the gaps between the abutting whiskers 5 for accommodating bone fragments in the medullary cavity can be selected, but the effect is not as good as both settings.

[0040] In this embodiment, if Figure 2 As shown, the support whiskers 5 include a hydrogel layer, and the hydrogel layer forms the outer surface of the support whiskers 5. Hydrogel is a type of extremely hydrophilic three-dimensional network structure gel that swells rapidly when exposed to water. When the rib bone plate of the present invention is in the process of implantation, the hydrogel layer will not expand immediately because the implantation process takes a short time. However, after the rib bone plate of the present invention is implanted, the body fluid in the bone marrow cavity has moisture, and this moisture is in contact with the hydrogel layer located at the support whiskers 5 for a long time. The hydrogel layer absorbs the moisture in the body fluid and gradually expands, so that the contact area between the support whiskers 5 and the inner wall of the bone marrow cavity increases, thereby increasing the friction between the support whiskers 5 and the inner wall of the bone marrow cavity located at the broken left bone 1a, thereby making the connection of the rib bone plate of the present invention more stable. In other embodiments, the support whiskers 5 can also be made entirely of silk protein, so that the support whiskers 5 have better flexibility.

[0041] In this embodiment, if Figure 2As shown, the support whiskers 5 also include a silk protein core, and the hydrogel layer covers the silk protein core. Due to the disadvantages of low strength and poor toughness of hydrogel, in order to prevent the support whiskers 5 from entering the bone marrow cavity and being squeezed and broken during the implantation of the rib bone fracture plate of the present invention. Therefore, it is necessary to set a silk protein core that plays a supporting role inside the hydrogel layer. Silk protein has good mechanical properties and physical and chemical properties, such as good flexibility and tensile strength. During the preparation of the support whiskers 5, the silk protein core is first fixed on the columnar portion 3, and then the hydrogel layer is coated on the outside of the silk protein core. The yield whiskers 6 can be made of only silk protein and cannot have a hydrogel component, so as to avoid affecting the accommodation of bone debris due to the expansion of the yield whiskers 6. In other embodiments, in order to reduce the preparation cost of the support whiskers 5, the support whiskers 5 can be completely composed of hydrogel, but in this embodiment, the support whiskers 5 are prone to breakage.

[0042] In this embodiment, if Figure 2 and Figure 3 As shown, one end of the abutting whisker 5 and the giving way whisker 6 are both connected to the side wall of the columnar portion 3, and the other end of the abutting whisker 5 abuts the inner wall of the bone marrow cavity of the broken left bone 1a. The abutting whisker 5 and the giving way whisker 6 are both inclined toward one side of the connecting portion 2, so each abutting whisker 5 and each giving way whisker 6 together form a structure similar to an arrowhead, which is convenient for the abutting whisker 5 and the giving way whisker 6 to move in the bone marrow cavity. In other embodiments, if the giving way whisker 6 is not provided, and there is no need to provide a gap between each abutting whisker 5 for accommodating bone debris, the middle part of each abutting whisker 5 can also be fixed on the columnar portion 3, and the fixing points of each abutting whisker 5 on the columnar portion 3 are located on the same radial section of the columnar portion 3, and the fixing points of each abutting whisker 5 on the columnar portion 3 are arranged at equal intervals, and both ends of each abutting whisker 5 are used to abut the inner wall of the bone marrow cavity.

[0043] In this embodiment, if Figure 2 and Figure 3 As shown, a guide portion 7 for opening a passage is provided at one end of the columnar portion 3 away from the connecting portion 2. In the direction away from the connecting portion 2, the cross-sectional area of ​​the guide portion 7 gradually decreases, that is, the tip of the guide portion 7 is arranged in the direction away from the connecting portion 2. In the present invention, by setting the guide portion 7, during the movement of the connecting portion 2 in the bone marrow cavity, the guide portion 7 pushes away the red bone marrow and other substances in the bone marrow cavity, thereby opening a passage for the connecting portion 2. In other embodiments, when there is no bone debris or other debris in the bone marrow cavity, the guide portion 7 can be provided.

[0044] In this embodiment, if Figure 2As shown, the surgical hole is provided on the side wall of the fractured right bone 1b. The guiding part 7, the columnar part 3, the yielding whisker 6, the abutting whisker 5 and the connecting part 2 pass through the surgical hole and enter the bone marrow cavity of the fractured right bone 1b. After the abutting whisker 5 abuts against the inner wall of the bone marrow cavity of the fractured left bone 1a, the fixing part 4 is fixed on the outer wall of the fractured right bone 1b. Specifically, the fixing part 4 is arranged closely against the outer wall of the fractured right bone 1b, and the fixing point of the fixing part 4 is arranged close to the surgical hole. By fixing the fixing part 4 on the outer wall of the fractured right bone 1b, the present invention facilitates the surgical operation. And since the surgical hole is arranged close to the fixing point of the fixing part 4, the surgical wound can be smaller. At the same time, since the fixing part 4 is arranged closely against the outer wall of the fractured right bone 1b, it is equivalent that both ends of the rib bone plate of the present invention have no gap with the rib, and it is not easy to cause rib dislocation due to human breathing. In other embodiments, the fixing part 4 can also be fixed on the inner wall of the bone marrow cavity of the fractured right bone 1b, so that the rib bone plate is completely arranged in the bone marrow cavity, but it is difficult to fix the fixing part 4.

[0045] In this embodiment, as Figure 2 shown, the connecting part 2, the columnar part 3, the fixing part 4 and the abutting whisker 5 are all made of degradable materials. Similarly, the yielding whisker 6 can also be made of degradable materials, that is, the rib bone plate of the present invention is all made of degradable materials. Conventional rib bone plates are usually made of metal materials that are not easily degradable. Therefore, after the fracture heals, the conventional rib bone plate needs to be removed again to avoid blocking the bone marrow cavity. Since the rib bone plate of the present invention is all made of degradable materials, during the process of rib fracture healing, the rib bone plate can be automatically degraded without the need for a second operation to remove the rib bone plate. In this embodiment, the degradable material can be silk protein, magnesium metal and other easily degradable metal materials.

[0046] In this embodiment, as Figure 6 shown, the connecting part 2, the columnar part 3, the fixing part 4 and the guiding part 7 are all integrally formed of degradable materials. In some embodiments without the guiding part 7, the connecting part 2, the columnar part 3 and the fixing part 4 are integrally formed of degradable materials. Whether there is a guiding part 7 or not, the structure composed of the connecting part 2, the columnar part 3, the fixing part 4 and the guiding part 7, or the structure composed of the connecting part 2, the columnar part 3 and the fixing part 4 in the present invention is collectively referred to as the bone plate matrix. The bone plate matrix is in the shape of a long strip plate. Therefore, after the bone plate matrix enters the bone marrow cavity, it will not block the bone marrow cavity, and there is still a large space for the nutrients in the bone marrow cavity to flow freely.

[0047] In this embodiment, as Figure 6 and Figure 7As shown in the figure, the bone plate matrix is composed of a reinforcing rib 8 and a silk fibroin layer covering the reinforcing rib 8. The connecting part 2, the columnar part 3, the fixing part 4, and the guiding part 7 all have reinforcing ribs. In some embodiments without the guiding part 7, the connecting part 2, the columnar part 3, and the fixing part 4 all have reinforcing ribs. The reinforcing rib 8 includes a magnesium wire 8a, and the reinforcing rib 8 also includes a PCL wire 8b and / or a PCLA wire 8c. The function of the reinforcing rib 8 is to enhance the strength of the bone plate matrix. PCL is the abbreviation of polylactic acid, and PCLA is the abbreviation of polylactic acid copolymer. Whether it is PCL or PCLA, acid is produced after degradation. And metallic magnesium produces alkali after degradation. Therefore, through acid-base neutralization, the bone plate matrix does not produce side effects on the human body after degradation. At the same time, silk fibroin is a natural polymer fiber protein that is biodegradable and harmless after degradation. Therefore, through the arrangement of the reinforcing rib 8 and the silk fibroin layer, on the premise that the strength of the bone plate matrix is guaranteed, the bone plate matrix is biodegradable. At the same time, due to the arrangement of the magnesium wire 8a, the rib bone plate of the present invention is visible under CT irradiation, which is convenient for doctors to clearly understand the position of the bone plate. In other embodiments, the bone plate matrix can also be made entirely of silk fibroin, but it is difficult to guarantee the strength of the bone plate matrix. It is necessary to design the shape of the bone plate matrix, such as designing the radial cross-section of the bone plate matrix to be triangular to enhance the strength of the bone plate matrix. However, the strength of the bone plate matrix in this embodiment is not as good as that of the present embodiment. At the same time, the bone plate matrix made only of silk fibroin cannot be visible under CT irradiation. Therefore, during the preparation of the bone plate matrix, contrast agents such as iohexol and iopamidol need to be added to the silk fibroin solution, and the contrast agent will cause damage to the kidneys.

[0048] In this embodiment, as Figure 7 shown, the PCL wire 8b and / or the PCLA wire 8c are wound around the magnesium wire 8a and braided to form the reinforcing rib 8. Figure 7 In it, the magnesium wire 8a is located in the middle, while the PCL wire 8b and the PCLA wire 8c are located on both sides of the magnesium wire 8a respectively. The present invention makes the acid-base neutralization more sufficient during the degradation of the reinforcing rib 8 by arranging the reinforcing rib 8 to be made of braiding such as the magnesium wire 8a. In other embodiments, in order to reduce the manufacturing cost and reduce the braiding steps of the reinforcing rib 8, the magnesium wire 8a, the PCL wire 8b, and the PCLA wire can also be arranged parallel to each other.

[0049] Regarding the structure of the bone plate matrix in this embodiment, the present invention also discloses a preparation method for the bone plate matrix, which specifically includes the following steps: Step 1, as Figure 7 shown, the PCL wire 8b and / or the PCLA wire 8c are mixed and braided with the magnesium wire 8a to form the reinforcing rib 8.

[0050] Step 2, as Figure 8As shown, the reinforcing rib 8 is bent to form a Z-like shape. Subsequently, the reinforcing rib 8 is placed into the casting container 9. The casting container 9 is a box-shaped container with an opening on one side. On the two opposite side walls of the casting container 9, there are accommodation holes for accommodating the ends of the reinforcing rib 8. During the process of placing the reinforcing rib 8 into the casting container 9, the two ends of the reinforcing rib 8 are respectively fixed in the accommodation holes on the side walls of the casting container 9. And to ensure the strength of the bone plate matrix, there are at least two reinforcing ribs 8, and each reinforcing rib 8 can be like Figure 9 shown, and each reinforcing rib 8 is arranged in parallel within the casting container 9; or like Figure 10 shown, and each reinforcing rib 8 is arranged crosswise in the casting container 9.

[0051] Step three, as Figure 8 shown, inject the silk fibroin solution into the casting container 9, and each reinforcing rib 8 is immersed in the silk fibroin solution. After casting, a bone plate embryo is obtained.

[0052] Step four, perform a subtractive manufacturing process on the bone plate embryo to machine and form a bone plate matrix as Figure 6 shown, and the bone plate matrix is in a Z-like shape.

[0053] In addition, for this embodiment, after obtaining the bone plate matrix through the casting process and the subtractive manufacturing process, it is also necessary to prepare the abutting whiskers 5 and the yielding whiskers 6 on the columnar part 3 to finally manufacture the rib bone plate of the present invention. The abutting whiskers 5 and the yielding whiskers 6 have the same structure, and the method for preparing the abutting whiskers 5 will be elaborated in detail below as an example. Specifically: The present invention provides a method for preparing a rib bone plate, including the following steps: Step one, provide a completed bone plate matrix.

[0054] Step two, mix the silk fibroin solution and the silver nanowire solution to form a first mixed solution. Specifically, add the silver nanowire solution to the silk fibroin solution. The concentration of the silver nanowire solution is between 0.5 - 2 mg / mL, the concentration of the silk fibroin solution is between 5 and 10 mg / mL, and the ratio of the silver nanowire solution to the silk fibroin solution is approximately 1:5 to 1:20. Since the silver nanowires are in a filamentous shape, the silver nanowire solution and the silk fibroin solution are relatively easy to mix. Rotate the mixed solution of the silk fibroin solution and the silver nanowire solution clockwise. The stirring speed is set at 300 - 500 revolutions per minute. Such a stirring speed can ensure that the silver nanowires are evenly dispersed in the silk fibroin solution while not damaging the silver nanowires in the mixed solution or generating too many unnecessary bubbles due to too fast a stirring speed. After continuous stirring for 2 to 3 hours, the silver nanowires are fully diffused in the silk fibroin solution, and thus the first mixed solution is obtained.

[0055] Step 3: Prepare a silk fibroin core using the first mixture. One end of the silk fibroin core is connected to the columnar part 3. Specifically, by means of 3D printing, a silk fibroin core with a diameter of 0.5 mm is additively manufactured on the side wall of the columnar part 3 using the first mixture. The angle between the axis of the silk fibroin core and the axis of the columnar part 3 is 35° to 45°.

[0056] Step 4: Mix the silk fibroin solution, gelatin, polypyrrole monomer, ferric chloride, glycerol, and chitosan to form a second mixture. Step 5: Immerse the silk fibroin core in the second mixture and form a hydrogel layer on the silk fibroin core through an electrochemical reaction to obtain the supporting whisker 5. Specifically, when the silk fibroin core is immersed in the second mixture, both the silk fibroin core and the platinum sheet are placed in the second mixture. Since the silk fibroin core contains nanosilver wires, it can serve as an electrode for the electrochemical reaction just like the platinum sheet. Subsequently, an electric current is applied to the silk fibroin core and the platinum sheet for the electrochemical reaction. Set the DC voltage applied to be 1.5 - 3 V, the current density applied to be 0.1 - 0.5 mA / cm², and the application time to be 10 - 30 minutes. During the electrochemical reaction, the negatively charged silk fibroin and polypyrrole monomer in the second mixture migrate and accumulate towards the silk fibroin core serving as the anode. Then, the iron ions in ferric chloride initiate the polymerization of the polypyrrole monomer on the surface of the silk fibroin core. At the same time, the silk fibroin and gelatin are cross-linked through hydrogen bond hydrophobic interactions, thereby forming a hydrogel layer on the surface of the silk fibroin core. Meanwhile, because the silk fibroin core contains filamentous nanosilver wires, during the electrochemical reaction, it is easier for the negatively charged silk fibroin and polypyrrole monomer in the second mixture to aggregate on the surface of the silk fibroin core.

[0057] In summary, the present invention provides a smaller surgical wound by providing the abutting whiskers 5; when the human body breathes, the rib bone fracture plate of the present invention is less deformed, and the broken left bone 1a and the broken right bone 1b are not easily misaligned. And by providing the yield whiskers 6, the possibility of bone debris falling into the chest cavity is greatly reduced. And by providing a gap between each abutting whisker 5 for accommodating bone debris in the bone marrow cavity, the possibility of bone debris falling into the chest cavity can also be reduced. And by providing the hydrogel layer, the connection of the rib bone fracture plate of the present invention is more stable. And by providing the abutting whiskers 5 to include a silk protein core, it is ensured that the abutting whiskers 5 have good mechanical properties and physical and chemical properties. And by providing the abutting whiskers 5 and the yield whiskers 6 to be inclined toward one side of the connecting part 2, it is convenient for the abutting whiskers 5 and the yield whiskers 6 to move in the bone marrow cavity. And by providing the guide part 7, it is convenient for the connecting part 2 to move in the bone marrow cavity. And by fixing the fixing part 4 to the outer wall of the broken right bone 1b, it is convenient for surgical operation. By setting the rib bone plates to be made of degradable materials, the rib bone plates do not need to be removed by a second operation. By setting the reinforcing ribs 8 and the silk protein layer, the bone plate matrix can be degraded while the strength of the bone plate matrix is ​​guaranteed, and the position of the bone plate matrix can be clearly understood under CT irradiation. By setting the reinforcing ribs 8 to be woven with magnesium wire 8a, etc., the acid-base neutralization is more sufficient during the degradation of the reinforcing ribs 8.

[0058] It should be emphasized that the above are only preferred embodiments of the present invention and do not limit the present invention in any form. Any simple modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A rib osteosynthesis plate for connecting a fractured left bone (1a) and a fractured right bone (1b), characterized in that, It includes a connecting part (2), a columnar part (3), a fixing part (4) and several abutting whiskers (5); The columnar part (3) is connected to the first end of the connecting part (2), and the fixing part (4) is connected to the second end of the connecting part (2); The abutting whiskers (5) are fixed on the side wall of the columnar part (3); The connecting part (2) is located in the marrow cavities of the fractured left bone (1a) and the fractured right bone (1b). The abutting whiskers (5) abut against the inner wall of the marrow cavity of the fractured left bone (1a), and there is a gap between the columnar part (3) and the inner wall of the marrow cavity. The fixing part (4) is connected to the fractured right bone (1b).

2. The rib osteosynthesis plate according to claim 1, characterized in that, It further includes several relief whiskers (6) provided on the columnar part (3). The relief whiskers (6) are all arranged on the side away from the connecting part (2) of the abutting whiskers (5), and there is a gap between the relief whiskers (6) and the inner wall of the marrow cavity; there is a gap for accommodating bone debris in the marrow cavity between the relief whiskers (6).

3. The rib plate according to claim 1, wherein, There is a gap for accommodating bone debris in the marrow cavity between the abutting whiskers (5).

4. The rib osteosynthesis plate according to claim 1, characterized in that, The abutting whisker (5) includes a hydrogel layer, and the hydrogel layer forms the outer surface of the abutting whisker (5); after the hydrogel layer absorbs body fluid and swells, the contact area between the abutting whisker (5) and the inner wall of the marrow cavity increases.

5. The rib osteosynthesis plate according to claim 1, characterized in that, The connecting part (2), the columnar part (3), the fixing part (4) and the abutting whisker (5) are all made of degradable materials.

6. The rib osteosynthesis plate according to claim 1, characterized in that, A guiding part (7) for opening a passage is provided at one end of the columnar part (3) away from the connecting part (2).

7. The rib osteosynthesis plate according to claim 1, characterized in that, There is a surgical hole on the side wall of the fractured right bone (1b). The columnar part (3), the abutting whiskers (5) and the connecting part (2) pass through the surgical hole and enter the marrow cavity, and the fixing part (4) is fixed on the outer wall of the fractured right bone (1b).

8. The rib osteosynthesis plate according to claim 2, characterized in that, One end of each of the abutting whiskers (5) and the relief whiskers (6) is connected to the side wall of the columnar part (3), and the other end of the abutting whisker (5) abuts against the inner wall of the marrow cavity of the fractured left bone (1a); both the abutting whiskers (5) and the relief whiskers (6) are inclined towards the side of the connecting part (2).

9. The rib plate according to claim 5, characterized in that, Reinforcing ribs (8) are provided in the connecting part (2), the columnar part (3) and the fixing part (4). The reinforcing ribs (8) are coated with a silk fibroin layer; the reinforcing ribs (8) include magnesium wires (8a) and include PCL wires (8b) and / or PCLA wires (8c).

10. The rib osteosynthesis plate according to claim 9, characterized in that, The PCL wires (8b) and / or the PCLA wires (8c) are wound around the magnesium wires (8a) to braid and form the reinforcing ribs (8).

11. The rib osteosynthesis plate according to claim 10, characterized in that, At least two reinforcing ribs (8) are provided; the reinforcing ribs (8) are arranged in parallel or the reinforcing ribs (8) are arranged in a cross pattern.

12. The rib osteosynthesis plate according to claim 4, characterized in that, The abutting whisker (5) further includes a silk fibroin core, and the hydrogel layer coats the silk fibroin core.

13. A method for preparing a rib osteosynthesis plate, which is used to prepare the rib osteosynthesis plate according to claim 12, characterized in that, It includes the following steps: Step 1, provide a bone plate substrate, and the bone plate substrate includes a columnar part (3), a connecting part (2) and a fixing part (4) connected in sequence; Step 2, mix a silk fibroin solution and a silver nanowire solution to form a first mixed solution; Step 3: Prepare the silk fibroin core using the first mixture, and connect one end of the silk fibroin core to the columnar part (3); Step 4: Mix the silk fibroin solution, gelatin, polypyrrole monomer, ferric chloride, glycerol, and chitosan to form a second mixture; Step 5: Immerse the silk fibroin core in the second mixture, and form a hydrogel layer on the silk fibroin core through an electrochemical reaction to obtain the supporting whisker (5).

14. A method for preparing an osteosynthesis plate substrate, characterized in that, For preparing the bone plate matrix described in claim 13, comprising the following steps, Step 1: Mix and braid PCL filaments (8b) and / or PCLA filaments (8c) with magnesium filaments (8a) to form a reinforcing rib (8); Step 2: Place the reinforcing rib (8) into a casting container (9), and fix both ends of the reinforcing rib (8) on the side walls of the casting container (9) respectively; Step 3: Inject the silk fibroin solution into the casting container (9), immerse the reinforcing rib (8) in the silk fibroin solution, and obtain a bone plate embryo after casting; Step 4: Perform a subtractive manufacturing process on the bone plate embryo to machine and form the bone plate matrix.

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