A tumor biopsy device

Abstract

This invention provides a tumor in vivo sampling device, relating to the field of biological sampling, comprising: a sampler body, the sampler body having a pistol-shaped structure; an inner sampling needle, the inner sampling needle being coaxially rotatably connected to the inner side of a reversing seat and rotatably connected to the inner side of an outer sampling cylinder, the right side cross-section of the outer sampling cylinder and the inner sampling needle having an arc-shaped structure, the right end of the outer sampling cylinder and the inner sampling needle having a needle-like spike structure, and both the right side arc-shaped portions of the outer sampling cylinder and the inner sampling needle having hollow sampling ports; and a sampling transmission assembly, the sampling transmission assembly being disposed inside the sampler body, the sampling operation block driving the outer sampling cylinder and the inner sampling needle to rotate simultaneously in opposite directions through the sampling transmission assembly. This device quickly and completely severs tumor tissue, avoiding tearing damage, achieving sample isolation from tissue, preventing sample mixing, and solving the problems of existing sampling processes that are difficult to effectively sever tissue, easily leading to tissue tearing and impure tissue samples.

Description

Technical Field

[0001] This invention relates to the field of biological sampling technology, and in particular to a tumor in vivo sampling device. Background Technology

[0002] In the process of tumor research, it is often necessary to conduct tumor-related experiments and studies using mice. In the process of mouse tumor research experiments, it is necessary to take live samples of the tumor in the mouse and then conduct further research on the tumor tissue. Currently, live sampling is generally carried out using a general-purpose puncture needle or a small forceps.

[0003] For example, application number CN202211329381.9 discloses a tumor tissue sampling pen, relating to the field of medical devices. This tumor tissue sampling pen includes a tissue cutting component, a rotating component, and a push rod assembly. The tissue cutting component includes a blade holder and a blade assembly, with the blade assembly disposed at one end of the blade holder. The rotating component includes a pen body mechanism, a rotating mechanism, and a connecting rod. Both the rotating mechanism and the connecting rod are disposed within the pen body mechanism. The rotating mechanism further includes a pen cap, a guide sleeve, and a rotating column. The pen cap and the rotating column are connected via the guide sleeve, and the end of the rotating column away from the guide sleeve abuts against one end of the connecting rod. The push rod assembly includes a thumb pressing part, a push rod, an elastic limiting member, a first elastic member, and a push sleeve. The elastic limiting member is disposed on the push rod near the thumb pressing part, the first elastic member and the push rod abut against each other, and the end of the push rod away from the thumb pressing part is connected to the push sleeve. By replacing different tissue cutting components and push sleeves, the size of the tumor tissue block to be cut can be adjusted.

[0004] However, existing sampling devices using universal puncture needles can only sample body fluids or individual free cells, and cannot sample tissues completely. While sampling with forceps can sample tissue, it is difficult to puncture the tissue, and it is difficult to effectively cut the tissue during the sampling process, which can easily lead to tissue tearing and affect the sample structure. At the same time, in mouse tumor tissue samples, they are prone to contact with skin, muscle and other tissues during removal, resulting in impurities in the tissue sample and affecting the sampling effect. Summary of the Invention

[0005] In view of this, the present invention provides a tumor in vivo sampling device, which adopts a sampling outer cylinder and an inner sampling needle that rotate synchronously in opposite directions. The cutting edge of the outer cylinder and the cutting edge of the inner needle form a scissor-like cutting effect, which quickly and completely cuts off the tumor tissue and avoids tearing damage. The hollow sampling port with a closed design can isolate the sample from the tissue and prevent sample mixing. In addition, the spike-shaped sampling tip can easily pierce tough tissue, reducing puncture resistance. Combined with the flexible adjustment function of the sampling port direction, it can accurately target tumor tissues of different locations and sizes, greatly improving sampling accuracy and providing high-quality samples for clinical pathological testing.

[0006] The present invention provides a purpose and effect of a tumor live sampling device, specifically including: a sampler body, the sampler body having a pistol-shaped structure;

[0007] The sampling operation block is slidably connected to the upper right side of the handle of the sampler body. The sampling operation block and the sampler body are elastically connected by a spring. A limit stop is provided on the inner side of the sampler body. The limit stop can limit the sliding range of the sampling operation block, so that the outer sampling cylinder and the inner sampling needle can only rotate within a 90-degree range.

[0008] The reversing operation knob is connected to the upper left side of the handle of the sampler body;

[0009] The reversing seat is rotatably connected inside the sampler body;

[0010] The sampling outer cylinder is coaxially rotatably connected to the inner side of the reversing seat;

[0011] The inner sampling needle is coaxially rotatably connected to the inner side of the reversing seat and rotatably connected to the inner side of the outer sampling cylinder. The right side cross-section of the outer sampling cylinder and the inner sampling needle is an arc-shaped structure, and the right end of the outer sampling cylinder and the inner sampling needle is a needle-shaped spike structure. Hollow sampling ports are opened on the right arc-shaped part of the outer sampling cylinder and the inner sampling needle.

[0012] The reversing drive assembly is located inside the sampler body. The reversing operation knob drives the reversing seat to rotate through the reversing drive assembly.

[0013] The sampling transmission assembly is located inside the sampler body. The sampling operation block drives the outer sampling cylinder and the inner sampling needle to rotate in opposite directions simultaneously through the sampling transmission assembly.

[0014] Furthermore, there are two reversing operation knobs, which rotate symmetrically on the front and rear end faces of the sampler body and are coaxially fixedly connected.

[0015] Furthermore, the commutation drive assembly includes:

[0016] The drive pulley is coaxially and fixedly connected to the middle of the two reversing operation knobs;

[0017] The intermediate drive gear is rotatably connected inside the sampler body;

[0018] The driven pulley is coaxially and fixedly connected to the rear end face of the intermediate driving gear. The driven pulley and the driving pulley are connected by a synchronous transmission belt to form a synchronous transmission belt transmission structure.

[0019] Furthermore, the reversing drive assembly also includes:

[0020] The reversing worm gear is rotatably connected inside the sampler body;

[0021] The intermediate driven gear is coaxially and fixedly connected to the front end face of the reversing worm. The intermediate driven gear meshes with the intermediate driving gear to form a gear transmission mechanism.

[0022] Furthermore, the reversing drive assembly also includes:

[0023] The reversing worm gear is rotatably connected inside the sampler body. The reversing worm and the reversing worm gear mesh together to form a worm gear transmission structure.

[0024] Furthermore, the reversing drive assembly also includes:

[0025] The reversing drive gear is coaxially and fixedly connected to the right end face of the reversing worm gear;

[0026] The reversing driven gear ring is coaxially and fixedly connected to the outside of the reversing seat. The reversing driving gear and the reversing driven gear ring mesh together to form a gear transmission structure.

[0027] Furthermore, the sampling transmission assembly includes:

[0028] A sampling drive rack is fixedly connected to the upper part of the sampling operation block;

[0029] An intermediate gear is rotatably connected inside the sampler body.

[0030] The push block is slidably connected inside the sampler body;

[0031] The sampling driven rack is fixedly connected to the bottom of the push block. The upper and lower parts of the intermediate gear mesh with the sampling driven rack and the sampling drive rack, respectively, to form a gear and rack transmission mechanism.

[0032] Furthermore, the sampling transmission assembly also includes:

[0033] The intermediate drive slider is slidably connected inside the reversing seat. The intermediate drive slider and the reversing seat are elastically connected by a spring. The left side of the intermediate drive slider is aligned with the push block.

[0034] The intermediate transmission rack has two intermediate transmission racks fixedly connected to the right side of the intermediate transmission slider. The intermediate transmission racks are arranged symmetrically at the center.

[0035] There are two sampling driven gears, which are rotatably connected inside the reversing seat. The sampling driven gears mesh with the intermediate transmission rack on the same side to form a gear and rack transmission mechanism.

[0036] Furthermore, the sampling transmission assembly also includes:

[0037] Two active bevel gears are provided, and the two active bevel gears are coaxially and fixedly connected inside the two sampling driven gears.

[0038] The driven bevel gear of the outer cylinder is coaxially and fixedly connected to the left end face of the sampling outer cylinder;

[0039] The inner needle driven bevel gear is coaxially and fixedly connected to the left end face of the inner sampling needle. The inner needle driven bevel gear and the outer cylinder driven bevel gear are arranged opposite each other. The two driving bevel gears mesh with the outer cylinder driven bevel gear and the inner needle driven bevel gear on both sides to form a bevel gear transmission structure.

[0040] Furthermore, the outer sampling cylinder has an inwardly opening outer cylinder cutting edge at the sampling port edge, and the inner sampling needle has an inwardly opening inner needle cutting edge at the sampling port edge.

[0041] Beneficial effects

[0042] This invention employs a pistol-shaped sampler body with symmetrical reversing control knobs, conforming to ergonomic design. The thumb and forefinger can naturally control the reversing and sampling actions. The outer sampling cylinder and inner sampling needle rotate synchronously in opposite directions, and the cutting edge of the outer cylinder and the cutting edge of the inner needle form a scissor-like cutting effect, quickly and completely cutting off tumor tissue and avoiding tearing damage. The hollow sampling port, combined with a closed design, isolates the sample from the tissue, preventing sample mixing. In addition, the spiked sampling tip can easily pierce tough tissue, reducing puncture resistance. Combined with the flexible adjustment function of the sampling port direction, it can accurately target tumor tissue of different locations and sizes, greatly improving sampling accuracy and providing high-quality samples for clinical pathological testing.

[0043] This invention employs a pistol-shaped sampler body, coupled with two symmetrically arranged reversing control knobs. Whether held in the left or right hand, the operator can naturally control the reversing and sampling actions using their thumb and forefinger, conforming to ergonomic principles. Simultaneously, the spring-loaded elastic connection between the sampling operation block and the sampler body, along with the precise limitation of the operating range by the limiting block, keeps the rotation angle of the outer sampling cylinder and inner sampling needle within a 90-degree range, preventing misoperation, significantly reducing operational difficulty, and improving sampling efficiency and comfort for medical personnel.

[0044] This invention utilizes the synchronous counter-rotation of the outer sampling cylinder and the inner sampling needle. During the closing process, the cutting edge of the outer cylinder and the cutting edge of the inner needle at the edge of the sampling port form a shearing effect similar to scissors, which can quickly and completely cut off the tumor tissue, avoiding tissue breakage or structural damage caused by tearing. The hollow sampling port design can completely store the cut sample, which can effectively ensure the closed state of the sampling port, so as to create an isolation effect between the sample and the tissue, effectively preventing the sample from mixing with other tissues during the removal of the sample from the body, and ensuring the purity and reliability of the pathological test sample.

[0045] This invention employs a sampling outer cylinder with a spike structure and an inner sampling needle tip, which can easily pierce the tough tissue surface and reduce puncture resistance. The device can be easily adjusted to change the opening direction of the sampling port according to different tumor locations, sizes, and tissue characteristics, making it easier to target the desired sampling site and obtain more accurate samples. Attached Figure Description

[0046] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings of the embodiments will be briefly described below.

[0047] The accompanying drawings described below are only related to some embodiments of the invention and are not intended to limit the invention.

[0048] In the attached diagram:

[0049] Figure 1 This is a schematic diagram of the overall structure of a tumor live sampling device according to an embodiment of the present invention.

[0050] Figure 2 This is a schematic diagram of the rear structure of a tumor live sampling device according to an embodiment of the present invention.

[0051] Figure 3 This is a schematic diagram of the internal structure of a tumor live sampling device according to an embodiment of the present invention.

[0052] Figure 4 This is a schematic diagram of the reversing transmission assembly of a tumor live sampling device according to an embodiment of the present invention.

[0053] Figure 5 This is a schematic diagram of the transmission structure of the commutator worm and commutator worm wheel of the tumor live sampling device according to an embodiment of the present invention.

[0054] Figure 6 This is a schematic diagram of the sampling transmission assembly of a tumor live sampling device according to an embodiment of the present invention.

[0055] Figure 7 This is a cross-sectional schematic diagram of the sampling transmission assembly of the tumor live sampling device according to an embodiment of the present invention.

[0056] Figure 8This is a schematic diagram of the internal structure of the reversing seat of the tumor live sampling device according to an embodiment of the present invention.

[0057] Figure 9 This is a schematic diagram of the sampling outer cylinder structure of the tumor live sampling device according to an embodiment of the present invention.

[0058] Figure 10 This is a schematic diagram of the internal sampling needle structure of the tumor live sampling device according to an embodiment of the present invention.

[0059] List of reference numerals

[0060] 1. Sampler body; 2. Sampling operation block; 201. Sampling drive rack; 3. Intermediate gear; 4. Push block; 401. Sampling driven rack; 5. Intermediate transmission slider; 501. Intermediate transmission rack; 6. Sampling driven gear; 7. Driven bevel gear; 8. Sampling outer cylinder; 801. Outer cylinder driven bevel gear; 802. Outer cylinder cutting edge; 9. Inner sampling needle; 901. Inner needle driven bevel gear; 902. Inner needle cutting edge; 10. Reversing operation knob; 1001. Drive pulley; 11. Intermediate drive gear; 1101. Driven pulley; 12. Reversing worm gear; 1201. Intermediate driven gear; 13. Reversing worm wheel; 1301. Reversing drive gear; 14. Reversing seat; 1401. Reversing driven gear ring. Detailed Implementation

[0061] Example 1: Please refer to Figures 1 to 5 As shown:

[0062] This invention provides a tumor live sampling device, including a sampler body 1. The sampler body 1 has a pistol-shaped structure, which is easy to hold and operate, and has better ergonomics.

[0063] Sampling operation block 2 is slidably connected to the upper right side of the handle of sampler body 1. Sampling operation block 2 and sampler body 1 are elastically connected by a spring. A limit stop is provided on the inner side of sampler body 1. The limit stop can limit the sliding range of sampling operation block 2, so that the outer sampling cylinder 8 and the inner sampling needle 9 can only rotate within a range of ninety degrees.

[0064] A reversing operation knob 10 is rotatably connected to the upper left side of the handle of the sampler body 1;

[0065] The reversing seat 14 is rotatably connected to the inside of the sampler body 1;

[0066] The sampling outer cylinder 8 is coaxially rotatably connected to the inner side of the reversing seat 14;

[0067] The inner sampling needle 9 is coaxially rotatably connected to the inner side of the reversing seat 14 and rotatably connected to the inner side of the outer sampling cylinder 8. The right side cross-section of the outer sampling cylinder 8 and the inner sampling needle 9 is an arc-shaped structure, and the right end of the outer sampling cylinder 8 and the inner sampling needle 9 is a needle-shaped spike structure. Hollow sampling ports are opened on the right arc-shaped parts of the outer sampling cylinder 8 and the inner sampling needle 9, and tumor tissue is sampled through the sampling ports.

[0068] The reversing drive assembly is located inside the sampler body 1. The reversing operation knob 10 drives the reversing seat 14 to rotate through the reversing drive assembly.

[0069] The sampler body 1 has two reversing operation knobs 10, which are symmetrically rotated on the front and rear ends of the sampler body 1. The two reversing operation knobs 10 are coaxially fixedly connected. In use, the sampler body 1 is held by the handle, the index finger operates the sampling operation block 2, and the thumb operates the reversing operation knob 10. With two symmetrical reversing operation knobs 10, the thumb can easily operate the reversing operation knob 10 whether the sampler is held with the left or right hand, making it convenient to use and more ergonomic.

[0070] The reversing drive assembly includes:

[0071] The drive pulley 1001 is coaxially and fixedly connected to the middle of the two reversing operation knobs 10;

[0072] The intermediate drive gear 11 is rotatably connected inside the sampler body 1.

[0073] Driven pulley 1101 is coaxially and fixedly connected to the rear end face of intermediate drive gear 11. Driven pulley 1101 and drive pulley 1001 are connected by synchronous transmission belt to form a synchronous transmission belt transmission structure. In use, when the reversing operation knob 10 is turned, the reversing operation knob 10 drives the intermediate drive gear 11 to rotate through the synchronous transmission belt transmission structure formed by driven pulley 1101 and drive pulley 1001.

[0074] The reversing drive assembly also includes:

[0075] The reversing worm gear 12 is rotatably connected inside the sampler body 1;

[0076] The intermediate driven gear 1201 is coaxially fixedly connected to the front end face of the reversing worm 12. The intermediate driven gear 1201 meshes with the intermediate driving gear 11 to form a gear transmission mechanism. In use, when the intermediate driving gear 11 rotates, the intermediate driving gear 11 drives the reversing worm 12 to rotate through the gear transmission mechanism formed by the meshing of the intermediate driven gear 1201 and the intermediate driving gear 11.

[0077] The reversing drive assembly also includes:

[0078] The reversing worm gear 13 is rotatably connected inside the sampler body 1. The reversing worm 12 and the reversing worm gear 13 mesh together to form a worm gear transmission structure. In use, when the reversing worm 12 rotates, the reversing worm 12 drives the reversing worm gear 13 to rotate through the worm gear transmission structure formed by the reversing worm 12 and the reversing worm gear 13. By utilizing the self-locking characteristic of the worm gear transmission mechanism, the rotation of the reversing seat 14 is effectively prevented during the sampling process, thus ensuring the accuracy of the sampling.

[0079] The reversing drive assembly also includes:

[0080] The reversing drive gear 1301 is coaxially and fixedly connected to the right end face of the reversing worm gear 13;

[0081] The reversing driven gear ring 1401 is coaxially fixedly connected to the outside of the reversing seat 14. The reversing driving gear 1301 and the reversing driven gear ring 1401 mesh together to form a gear transmission structure. In use, when the reversing worm gear 13 rotates, the reversing worm gear 13 drives the reversing seat 14 to rotate through the gear transmission structure formed by the reversing driving gear 1301 and the reversing driven gear ring 1401.

[0082] Example 2: Please refer to Figures 6 to 10 As shown:

[0083] The present invention provides a tumor live sampling device, including a sampling transmission assembly, which is disposed inside the sampler body 1. The sampling operation block 2 drives the outer sampling cylinder 8 and the inner sampling needle 9 to rotate in opposite directions simultaneously through the sampling transmission assembly.

[0084] The sampling transmission assembly includes:

[0085] Sampling drive rack 201 is fixedly connected to the upper part of sampling operation block 2;

[0086] Intermediate gear 3 is rotatably connected inside the sampler body 1;

[0087] Push block 4 is slidably connected inside the sampler body 1;

[0088] The sampling driven rack 401 is fixedly connected to the bottom of the push block 4. The upper and lower parts of the intermediate gear 3 mesh with the sampling driven rack 401 and the sampling drive rack 201 respectively to form a gear and rack transmission mechanism. In use, when the sampling operation block 2 is pressed to the left, the sampling operation block 2 drives the intermediate gear 3 to rotate through the gear and rack transmission mechanism. The intermediate gear 3 drives the push block 4 to slide left and right through the gear and rack transmission mechanism.

[0089] The sampling transmission assembly also includes:

[0090] The intermediate transmission slider 5 is slidably connected inside the reversing seat 14. The intermediate transmission slider 5 and the reversing seat 14 are elastically connected by a spring. The left side of the intermediate transmission slider 5 is aligned with the push block 4.

[0091] The intermediate transmission rack 501 and the intermediate transmission slider 5 have two intermediate transmission racks 501 fixedly connected to the right side of the intermediate transmission rack 5. The intermediate transmission racks 501 are arranged symmetrically at the center.

[0092] Sampling driven gear 6, there are two of them, and the two sampling driven gears 6 are rotatably connected inside the reversing seat 14. The sampling driven gear 6 meshes with the intermediate transmission rack 501 on the same side to form a gear and rack transmission mechanism. In use, when the push block 4 slides to the right, the push block 4 pushes the intermediate transmission slider 5 to slide to the right. The intermediate transmission slider 5 drives the two sampling driven gears 6 to rotate synchronously in opposite directions through the gear and rack transmission mechanism.

[0093] The sampling transmission assembly also includes:

[0094] Two active bevel gears 7 are provided, and the two active bevel gears 7 are coaxially fixedly connected inside the two sampling driven gears 6 respectively;

[0095] The driven bevel gear 801 of the outer cylinder is coaxially and fixedly connected to the left end face of the sampling outer cylinder 8;

[0096] The inner needle driven bevel gear 901 is coaxially fixedly connected to the left end face of the inner sampling needle 9. The inner needle driven bevel gear 901 is arranged opposite to the outer cylinder driven bevel gear 801. The two driving bevel gears 7 mesh with the outer cylinder driven bevel gear 801 and the inner needle driven bevel gear 901 on both sides to form a bevel gear transmission structure. In use, when the sampling driven gear 6 rotates, the sampling driven gear 6 drives the driving bevel gear 7 to rotate. The driving bevel gear 7 drives the outer cylinder driven bevel gear 801 and the inner needle driven bevel gear 901 to slide synchronously in opposite directions through the bevel gear transmission mechanism, realizing the synchronous reverse rotation of the sampling outer cylinder 8 and the inner sampling needle 9.

[0097] The outer sampling cylinder 8 has an inwardly opening outer cylinder cutting edge 802 at the sampling port edge, and the inner sampling needle 9 has an inwardly opening inner needle cutting edge 902 at the sampling port edge. In the initial state, the sampling ports of the outer sampling cylinder 8 and the inner sampling needle 9 are overlapping. When the outer sampling cylinder 8 and the inner sampling needle 9 rotate synchronously in opposite directions, the sampling port closes. The tumor tissue is sheared by the outer cylinder cutting edge 802 and the inner needle cutting edge 902 to achieve the sampling action. At the same time, the sampling ports of the outer sampling cylinder 8 and the inner sampling needle 9 together form a closed cavity structure.

[0098] The specific usage and function of this embodiment: When using this invention, hold the handle of the sampler body 1, operate the sampling operation block 2 with the index finger, and operate the reversing operation knob 10 with the thumb. During sampling, the sampling tissue is pierced by the spikes at the right end of the outer sampling cylinder 8 and the inner sampling needle 9. When it is necessary to adjust the orientation of the sampling port, the thumb moves the reversing operation knob 10. The reversing operation knob 10 drives the intermediate driving gear 1 through the synchronous transmission belt transmission structure composed of the driven pulley 1101 and the driving pulley 1001. 1. Rotation: The intermediate driving gear 11, through a gear transmission mechanism consisting of the intermediate driven gear 1201 meshing with the intermediate driving gear 11, drives the reversing worm 12 to rotate. The reversing worm 12, through a worm gear transmission structure consisting of the reversing worm 12 and the reversing worm wheel 13, drives the reversing worm wheel 13 to rotate. The reversing worm wheel 13, through a gear transmission structure consisting of the reversing driving gear 1301 and the reversing driven gear ring 1401, drives the reversing seat 14 to rotate. The reversing seat 14 drives the sampling outer cylinder 8 and the inner sampling needle to rotate. 9. Simultaneously rotate to change the opening direction of the sampling port; when the tissue to be sampled is selected, press the sampling operation block 2. The sampling operation block 2 drives the intermediate gear 3 to rotate through the gear and rack transmission mechanism. The intermediate gear 3 drives the push block 4 to slide to the right through the gear and rack transmission mechanism. The push block 4 pushes the intermediate transmission slider 5 to slide to the right. The intermediate transmission slider 5 drives the two sampling driven gears 6 to rotate synchronously in opposite directions through the gear and rack transmission mechanism. The sampling driven gears 6 drive the driving bevel gear 7 to rotate. Wheel 7 drives the outer cylinder driven bevel gear 801 and the inner needle driven bevel gear 901 to slide synchronously in opposite directions through the bevel gear transmission mechanism, realizing the synchronous reverse rotation of the sampling outer cylinder 8 and the inner sampling needle 9. The sampling port is closed, and the tumor tissue is cut by the outer cylinder cutting edge 802 and the inner needle cutting edge 902 to realize the sampling action. The cut sample is stored in the sampling port. When the sampling operation block 2 is released, the sampling outer cylinder 8 and the inner sampling needle 9 return to their positions under the action of the spring, and the sampling port opens, so that the sample in the sampling port can be extracted.

Claims

1. A tumor in vivo sampling device, characterized in that, include: The sampler body (1) is a pistol-shaped structure; Sampling operation block (2), the sampling operation block (2) is slidably connected to the upper right side of the handle of the sampler body (1), the sampling operation block (2) and the sampler body (1) are elastically connected by a spring, and a limit stop is provided on the inner side of the sampler body (1). A reversing operation knob (10) is rotatably connected to the upper left side of the handle of the sampler body (1); A reversing seat (14) is rotatably connected inside the sampler body (1); The sampling outer cylinder (8) is coaxially rotatably connected to the inner side of the reversing seat (14); The inner sampling needle (9) is coaxially rotatably connected to the inner side of the reversing seat (14) and rotatably connected to the inner side of the sampling outer cylinder (8). The right side cross section of the sampling outer cylinder (8) and the inner sampling needle (9) is an arc-shaped structure. The right end of the sampling outer cylinder (8) and the inner sampling needle (9) is a needle-shaped spike structure. Hollow sampling ports are opened on the right arc-shaped part of the sampling outer cylinder (8) and the inner sampling needle (9). A reversing transmission assembly is installed inside the sampler body (1). The reversing operation knob (10) drives the reversing seat (14) to rotate through the reversing transmission assembly. The sampling transmission assembly is located inside the sampler body (1). The sampling operation block (2) drives the outer sampling cylinder (8) and the inner sampling needle (9) to rotate in opposite directions simultaneously through the sampling transmission assembly. The sampling transmission assembly includes: A sampling drive rack (201) is fixedly connected to the upper part of the sampling operation block (2); Intermediate gear (3), which is rotatably connected inside the sampler body (1); Push block (4), which is slidably connected inside the sampler body (1); The sampling driven rack (401) is fixedly connected to the bottom of the push block (4). The upper and lower parts of the intermediate gear (3) mesh with the sampling driven rack (401) and the sampling drive rack (201) respectively to form a gear and rack transmission mechanism. The intermediate transmission slider (5) is slidably connected inside the reversing seat (14). The intermediate transmission slider (5) and the reversing seat (14) are elastically connected by a spring. The left side of the intermediate transmission slider (5) is aligned with the push block (4). Intermediate transmission rack (501), two intermediate transmission racks (501) are fixedly connected to the right side of the intermediate transmission slider (5), and the intermediate transmission racks (501) are arranged symmetrically at the center. Sampling driven gear (6), there are two sampling driven gears (6), the two sampling driven gears (6) are rotatably connected inside the reversing seat (14), and the sampling driven gear (6) meshes with the intermediate transmission rack (501) on the same side to form a gear and rack transmission mechanism. Two active bevel gears (7) are provided, and the two active bevel gears (7) are coaxially fixedly connected inside the two sampling driven gears (6); The outer cylinder driven bevel gear (801) is coaxially fixedly connected to the left end face of the sampling outer cylinder (8); The inner needle driven bevel gear (901) is coaxially fixedly connected to the left end face of the inner sampling needle (9). The inner needle driven bevel gear (901) and the outer cylinder driven bevel gear (801) are arranged opposite to each other. The two driving bevel gears (7) mesh with the outer cylinder driven bevel gear (801) and the inner needle driven bevel gear (901) on both sides to form a bevel gear transmission structure.

2. The tumor live sampling device as described in claim 1, characterized in that: There are two reversing operation knobs (10). The two reversing operation knobs (10) rotate symmetrically on the front and rear end faces of the sampler body (1). The two reversing operation knobs (10) are coaxially fixedly connected.

3. The tumor biopsy device of claim 1, wherein: The reversing drive assembly includes: The drive pulley (1001) is coaxially fixedly connected to the middle of the two reversing operation knobs (10); The intermediate drive gear (11) is rotatably connected inside the sampler body (1); Driven pulley (1101) is coaxially fixedly connected to the rear end face of intermediate drive gear (11). Driven pulley (1101) and drive pulley (1001) are connected by synchronous drive belt to form a synchronous drive belt drive structure.

4. The tumor biopsy device of claim 3, wherein: The reversing drive assembly also includes: A reversing worm gear (12) is rotatably connected inside the sampler body (1); The intermediate driven gear (1201) is coaxially fixedly connected to the front end face of the reversing worm (12). The intermediate driven gear (1201) meshes with the intermediate driving gear (11) to form a gear transmission mechanism.

5. The tumor biopsy device of claim 4, wherein: The reversing drive assembly also includes: A reversing worm gear (13) is rotatably connected inside the sampler body (1). The reversing worm (12) meshes with the reversing worm gear (13) to form a worm gear transmission structure.

6. The tumor biopsy device of claim 5, wherein: The reversing drive assembly also includes: A reversing drive gear (1301) is coaxially fixedly connected to the right end face of the reversing worm gear (13); The reversing driven gear ring (1401) is coaxially fixedly connected to the outside of the reversing seat (14). The reversing driving gear (1301) meshes with the reversing driven gear ring (1401) to form a gear transmission structure.

7. The tumor biopsy device of claim 1, wherein: The outer sampling cylinder (8) has an inner cylinder cutting edge (802) opening inward at the sampling port edge, and the inner sampling needle (9) has an inner needle cutting edge (902) opening inward at the sampling port edge.

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