Traditional Chinese medicine formula for treating cerebral infarction

Abstract

The invention discloses a traditional Chinese medicine formula for treating cerebral infarction, which comprises the following components: 10-25g of ligusticum wallichii, 10-20g of peach kernel, 10-25g of safflower, 10-25g of radix paeoniae rubra, 35-80g of salvia miltiorrhiza, 10-20g of pseudo-ginseng, 3-10g of leech, 10-25g of angelica sinensis, 15-35g of rehmannia, 6-15g of arisaema cum bile, 5-10g of platycodon grandiflorum, 6-25g of earthworm, 6-15g of poria cocos, 35-100g of astragalus membranaceus, 5-15g of radix bupleuri and 10-35g of gynostemma pentaphylla. The invention relates to the technical field of traditional Chinese medicines for treating cerebral infarction. All medicines in the traditional Chinese medicine formula have the following functions: (1) the traditional Chinese medicine has the effects of resisting hypercoagulation, high viscosity, high viscosity and high aggregation; (2) the composition has the effects of activating the activity of fibrinolytic enzyme and promoting dissolution of fibrin, so that thrombosis can be resisted, and thrombus and plaques can be dissolved; and (3) the traditional Chinese medicine composition has the effects of expanding blood vessels, resisting vasospasm and improving brain microcirculation.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines for treating cerebral infarction, and specifically to a traditional Chinese medicine formula for treating cerebral infarction. Background Art

[0002] Stroke (including cerebral infarction, cerebral hemorrhage, etc.) is one of the most common diseases in the global human population. Since 2010, it has been the number one killer of human diseases causing death and disability. Among them, ischemic stroke (including cerebral infarction, etc.) accounts for more than 70%. According to the latest international statistical data, according to the survey data of the international authoritative medical journal "The Lancet" on March 22, 2021, the number of newly added cases of cerebral infarction worldwide each year is 13.7 million, and in China it is 5.51 million. The number of deaths each year is 1.68 million, and the number of disabled reaches more than 2 million, and it is still on the rise year by year. Therefore, seeking a treatment method that is both safe and very effective has always been the goal and direction for medical workers to continuously explore and research.

[0003] There are three existing methods for treating cerebral infarction:

[0004] 1. Traditional conservative treatment

[0005] That is, systematically applying anticoagulation, volume expansion, vasodilation, anti-cerebral edema, neurotrophic, symptomatic and other treatments. The effective rate is about 70%, and the cure rate is about 40%.

[0006] 2. Thrombolytic therapy

[0007] Generally, a thrombolytic drug (Yt-PA), a recombinant tissue-type plasminogen activator, is intravenously injected within ≤ 4.5 hours after the onset of the disease.

[0008] Efficacy: The success rate is about 30%, and the mortality rate is about 6%.

[0009] 1. Cerebral hemorrhage, accounting for about 10%

[0010] 2. Cerebral hyperperfusion syndrome after thrombolytic vascular recanalization

[0011] 3. Allergy, 0.1 - 1%

[0012] 4. Vascular re-occlusion

[0013] 5. Cerebral edema

[0014] Overall, about 11.8% of patients experience deterioration of their condition.

[0015] 3. Embolectomy therapy

[0016] Surgical treatment is generally carried out within < 4.5 - 6 hours after the onset of the disease.

[0017] Efficacy: The recanalization rate is 66.7%.

[0018] Major Complications:

[0019] 1. Cerebral hemorrhage

[0020] 2. Recurrent cerebral infarction

[0021] 3. Arterial dissection

[0022] 4. Post-recanalization cerebral hyperperfusion syndrome

[0023] 5. Brain edema Summary of the Invention

[0024] The present invention provides a traditional Chinese medicine formula for treating cerebral infarction, which is mainly used for the treatment of cerebral infarction diseases and solves the problem that the existing treatment methods are difficult to cure cerebral infarction.

[0025] To achieve the above objectives, the present invention is realized through the following technical solutions: A traditional Chinese medicine formula for treating cerebral infarction, and the composition components of the traditional Chinese medicine formula include:

[0026] 10 - 25 grams of Chuanxiong Rhizoma, 10 - 20 grams of Persica Kernel, 10 - 25 grams of Carthamus Tinctorius, 10 - 25 grams of Red Peony Root, 35 - 80 grams of Salvia Miltiorrhiza, 10 - 20 grams of Notoginseng Root, 3 - 10 grams of Hirudo, 10 - 25 grams of Angelica Sinensis, 15 - 35 grams of Rehmannia Root, 6 - 15 grams of Arisaema Cum Bile, 5 - 10 grams of Platycodon Root, 6 - 25 grams of Pheretima, 6 - 15 grams of Poria, 35 - 100 grams of Astragalus Root, 5 - 15 grams of Bupleurum Root, 10 - 35 grams of Gynostemma Pentaphyllum.

[0027] Chuanxiong Rhizoma can improve cerebral microcirculation and restore the function of neuron cells. It can make the degenerated nerve dendrite cells return to normal, relieve cerebral vasospasm, significantly reduce brain edema, and lower intracranial pressure.

[0028] Red Peony Root can dissolve thrombus, eliminate plaque, and dilate blood vessels.

[0029] Carthamus Tinctorius can significantly reduce the degree of ischemic brain damage, make the activity of tissue chemical enzyme systems return to normal, reduce brain edema, and lower intracranial pressure.

[0030] Salvia Miltiorrhiza can dilate cerebral microvessels and has the effect of improving cerebral microcirculation. It has significant anticoagulant and fibrinolytic enhancing effects, and has a very obvious effect on improving hematocrit, whole blood viscosity, and plasma viscosity.

[0031] Notoginseng Root reduces blood viscosity, dilates microvessels, has an anti-inflammatory reaction, and reduces the formation of arterial thrombus and plaque. When the blood vessel wall is intact, it can counteract the platelet aggregation activation effect of ADP (adenosine diphosphate), reduce blood viscosity, increase blood flow rate, and achieve the effect of promoting blood circulation. When the blood vessel wall is damaged and blood overflows, ADP immediately activates platelet aggregation to play a hemostatic role. When bleeding stops, it can immediately counteract the ADP activity to end platelet aggregation and restore the blood circulation function.

[0032] Peach kernel has the effects of anticoagulation, dilating cerebral microvessels and improving cerebral microcirculation.

[0033] Leeches have a strong anticoagulant effect, reduce blood adhesion, and have a strong fibrinolytic effect.

[0034] Angelica sinensis has the effects of lowering blood lipids, dilating blood vessels, anti-coagulation, and improving cerebral microcirculation.

[0035] Rehmannia root has anti-inflammatory and thrombosis-inhibiting effects.

[0036] Astragalus has the effects of dilating blood vessels, improving cerebral microcirculation, and increasing the tolerance of brain neurons and glial cells to ischemic cerebral infarction.

[0037] Platycodon grandiflorum has the effect of significantly reducing cerebral edema and alleviating intracranial pressure.

[0038] Bupleurum has the effects of lowering blood lipids, anti-inflammatory, sedative and inhibiting thrombosis.

[0039] Earthworms have sedative, anticonvulsant, and anti-epileptic effects, and can enhance fibrinolysis.

[0040] Arisaema has anticonvulsant, anti-epileptic, anti-tremor and anti-inflammatory effects.

[0041] Gynostemma pentaphyllum has the effects of anti-hyperlipidemia, anti-atherosclerosis, protecting vascular endothelial cells, anti-thrombosis, and anti-neuronal cell apoptosis.

[0042] Poria cocos has anti-inflammatory, free radical scavenging, diuretic, relieving cerebral edema and reducing intracranial pressure effects.

[0043] Beneficial Effects

[0044] The present invention provides a Chinese medicine formula for treating cerebral infarction, which has the following beneficial effects:

[0045] The Chinese medicine formula is mainly used to treat ischemic cerebrovascular disease, including cerebral ischemia and cerebral infarction.

[0046] Chuanxiong, Carthamus tinctorius, Paeonia lactiflora, Salvia miltiorrhiza, and Panax notoginseng promote blood circulation, dissipate blood stasis, and dredge the meridians. Peach kernel and Hirudovirus, the blood-clearing and stasis-dissolving herbs, are used as the main herbs to enhance their stasis-dissipating function. Angelica sinensis and Rehmannia glutinosa nourish and harmonize the blood, dispelling stasis without damaging it. Arisaema consanguineum and Poria cocos dry dampness, resolve phlegm, and dissipate turbidity. Earthworm expels wind, calms wind, and dredges the meridians. Astragalus membranaceus and Gynostemma pentaphyllum, combined with the blood-stimulating herb Chuanxiong, replenish qi and tonify qi, serve as assistant herbs. Bupleurum chinense and Platycodon grandiflorum soothe the liver and regulate qi, guiding the herbs upward to the brain meridians. The entire formula achieves the functions of expelling wind and extinguishing wind, drying dampness and resolving phlegm, replenishing qi and tonifying qi, promoting blood circulation and dissipating blood stasis, and dredging the brain meridians.

[0047] The medicine of this Chinese medicine formula has the following functions to treat symptoms of cerebral blood supply insufficiency and cerebral infarction:

[0048] (1) It has the effects of anti - hypercoagulation, anti - high viscosity, anti - high thickness, and anti - high aggregation.

[0049] (2) It has the activity of activating fibrinolysin and promoting the dissolution of fibrin, thus can resist thrombosis, dissolve thrombus and plaque.

[0050] (3) It has the effects of dilating blood vessels, anti - vasospasm, and improving cerebral microcirculation.

[0051] (4) It can reduce the chemical inflammatory reaction of cerebral microvessels, brain neuron cells and brain glial cells caused by ischemia, which is crucial for protecting the recovery of brain neuron cells.

[0052] (5) It can improve the permeability of cerebral blood vessels, especially cerebral microvessels. It can improve the balance of crystal and colloid osmotic pressure inside and outside cells, thus has the obvious effects of reducing cerebral edema and intracranial pressure.

[0053] (6) It can improve the metabolic functions of brain neuron cells and brain glial cells. Due to cerebral damage caused by ischemia, the lipid peroxide (IPO) in the brain increases significantly. It can cause changes in the cell membranes of brain neurons and brain glial cells, and damage the RNA and DNA structures, thus leading to apoptosis and necrosis of brain neuron cells and brain glial cell membranes. The effective factors against and clearing LPO are the content and activity of superoxide dismutase (SOD) in the body. This traditional Chinese medicine formula has this effect. Gynostemma pentaphyllum plays a particularly prominent role in this regard. Gypenoside Ⅲ can significantly increase the SOD content and activity in the brain and liver, which is crucial for protecting and reducing the damage of brain neuron cells and brain glial cell membranes, promoting the recovery of their functions, and reducing and alleviating the sequelae of cerebral infarction. Description of the Drawings

[0054] Figure 1 This is the SPT classification table of the present invention.

[0055] Figure 2 This is the efficacy statistical table of this traditional Chinese medicine formula of the present invention.

[0056] Figure 3 This is the comparison diagram of cerebral CTA angiography before and after the patient of the present invention takes the traditional Chinese medicine formula.

[0057] Figure 4 This is the comparison diagram of cerebral CTA middle cerebral artery angiography before and after the patient of the present invention takes the traditional Chinese medicine formula. Detailed Implementation Modes

[0058] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0059] The present invention provides a technical solution: a traditional Chinese medicine formula for treating cerebral infarction, the components of the traditional Chinese medicine formula comprising:

[0060] Chuanxiong 10-25g, peach kernel 10-20g, safflower 10-25g, red peony root 10-25g, salvia miltiorrhiza 35-80g, Panax notoginseng 10-20g, leech 3-10g, angelica 10-25g, rehmannia glutinosa 15-35g, arisaema strychnifolia 6-15g, platycodon 5-10g, earthworm 6-25g, poria 6-15g, astragalus 35-100g, bupleurum 5-15g, gynostemma pentaphyllum 10-35g;

[0061] According to Traditional Chinese Medicine (TCM), the essence of cerebral infarction is blood stasis, and wind, dampness, phlegm, and qi deficiency all contribute to the formation of blood stasis in the brain. Therefore, the main focus is on promoting blood circulation, removing blood stasis, and unblocking the meridians, supplemented by dispelling wind, eliminating dampness, resolving phlegm, and invigorating qi to promote blood circulation, thereby resolving wind, phlegm, dampness, qi deficiency, and blood stasis, thereby unblocking the brain meridians.

[0062] In order to facilitate treatment and prognosis judgment, patients with cerebral infarction are divided into five types. This classification method is initially named "SPT (Sun Pi Tong) classification method for cerebral infarction".

[0063] 580 cases were cured, with a cure rate of 96.6% and an effective rate of 99.6%.

[0064] “Complete cure” means no sequelae.

[0065] The shorter the time from onset of cerebral infarction to treatment, the faster, higher and more complete the therapeutic effect.

[0066] In general:

[0067] ⑴ Seek medical attention within 6 hours of onset and the medication will take effect within 1 day.

[0068] ⑵ Seek medical attention within 24 hours of onset, and the medication will be effective within 1-3 days.

[0069] ⑶ Seek medical attention within 1 week of onset, and the medication will be effective within 1-7 days.

[0070] As the time from onset to consultation increases, the speed and extent of therapeutic effect gradually weaken.

[0071] Those skilled in the art shall process the Chinese medicinal materials in this case. For the specific processing and operation sequence, reference should be made to the following working principle. The detailed connection means are well-known techniques in the art. The following mainly introduces the working principle and process.

[0072] Example 1:

[0073] Patient: Male, 60 years old.

[0074] Chief complaint: Sudden numbness on the left side of the face and left limb accompanied by weakness of the left limb for one week.

[0075] Medical history: On May 4, 2022, without any inducement, suddenly felt numbness on the left side of the face and left limb, and then found weakness of the left limb and inability to walk. Went to the local hospital for a head CT scan, which showed a cerebral infarction in the right internal capsule area. After one week of treatment, there was no effect, and he visited on May 11, 2022.

[0076] Physical examination: Conscious and cooperative, weakness of the left limb, unable to stand and walk. The muscle strength of the upper left side was grade IV, the muscle strength of the left lower limb was grade III, left Babinski sign (+), and the rest of the nervous system and vital signs were normal.

[0077] Head CTA examination showed 95% stenosis of the M1 and M2 segments of the right middle cerebral artery. The tongue was dark red, the tongue coating was white, the sublingual collaterals were cyanotic, and the pulse was stringy.

[0078] Western medicine diagnosis: Cerebral infarction.

[0079] Traditional Chinese medicine diagnosis: Wind-phlegm stasis blocking the brain collaterals syndrome.

[0080] Treatment method: Extinguish wind and resolve phlegm, promote blood circulation to remove stasis, and dredge the brain collaterals.

[0081] Traditional Chinese medicine formula: 10 grams of Ligusticum chuanxiong, 10 grams of Prunus persica, 10 grams of Carthamus tinctorius, 10 grams of Paeonia lactiflora, 35 grams of Salvia miltiorrhiza, 10 grams of Panax notoginseng, 3 grams of Hirudo, 10 grams of Angelica sinensis, 15 grams of Rehmannia glutinosa, 6 grams of Arisaema cum Bile, 5 grams of Platycodon grandiflorum, 6 grams of Pheretima, 6 grams of Poria cocos, 35 grams of Astragalus membranaceus, 5 grams of Bupleurum chinense, 35 grams of Gynostemma pentaphyllum. Decoct into decoction, take one dose daily, take the medicine for one week, and the numbness on the left side of the face and left limb improved significantly, and could stand and walk 1000 meters. After taking the medicine for three months, except for slight numbness on the left temple and the outer side of the left calf, the others returned to normal. Rechecked the head CTA after 3 months, and the plaques at the M1 and M2 of the right middle cerebral artery disappeared, and the local stenosis returned to normal.

[0082] Example 2:

[0083] Patient: Male, 42 years old.

[0084] Chief complaint: Weakness of the right limb accompanied by right-sided facial distortion for 1 year and 9 months.

[0085] Medical history: In May 2021, the patient suddenly developed paralysis of the right limbs and right mouth and eye deviation without any cause. He went to the hospital for a head CT and CTA examination, which confirmed multiple cerebral infarctions and distal occlusion of the left middle cerebral artery M1. After treatment, there was some improvement, but the recovery was not ideal. He came to the hospital for treatment on February 10, 2023.

[0086] Physical examination: alert and cooperative, irritable, depressed, with mild right facial paresis and right limb weakness, unable to stand or walk. Muscle strength in the right upper limb was grade III, right lower limb strength was grade III, left-Babinz syndrome (positive), blood pressure 200 / 130 mmHg, pulse 82 beats / min, rest (-), dark red tongue, cyanotic sublingual veins, greasy white tongue coating, and a wiry pulse.

[0087] Western medicine diagnosis: multiple cerebral infarctions and hypertension.

[0088] TCM diagnosis: Liver wind disturbing the upper part, phlegm, dampness and blood stasis blocking the brain vessels.

[0089] Treatment method: calm the liver and extinguish wind, dry dampness and resolve phlegm, activate blood circulation, remove blood stasis and unclog brain meridians.

[0090] Traditional Chinese medicine formula: 15 grams of Chuanxiong, 10 grams of peach kernel, 15 grams of safflower, 15 grams of red peony root, 35 grams of salvia miltiorrhiza, 10 grams of Panax notoginseng, 3 grams of leech, 10 grams of angelica, 35 grams of Rehmannia glutinosa, 6 grams of Arisaema consanguineum, 5 grams of Platycodon grandiflorum, 25 grams of earthworm, 6 grams of Poria cocos, 35 grams of Astragalus membranaceus, 15 grams of Bupleurum chinense, 35 grams of Gynostemma pentaphyllum. Boil them into a decoction and take it once a day. After one week of medication, the symptoms improved and the blood pressure dropped to 130 / 80 mmHg. After taking the medicine for 3 months, the patient was in good mental state, the right hemiplegia disappeared, the right limb muscle strength was grade V, and the right-left Babinski's disease (-) returned to normal. A follow-up head CTA showed that the middle cerebral artery was completely open.

[0091] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "include," "comprise," or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article, or device that includes a series of elements includes not only those elements, but also other elements not explicitly listed, or elements inherent to such process, method, article, or device. In the absence of further limitations. The phrase "includes an element defined by..." does not exclude the presence of other identical elements in the process, method, article, or device that includes the element.

[0093] Although embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine formula for treating cerebral infarction, characterized in that, The components of the traditional Chinese medicine formula include: 10 - 25 grams of Ligusticum wallichii, 10 - 20 grams of Prunus persica, 10 - 25 grams of Carthamus tinctorius, 10 - 25 grams of Paeonia lactiflora, 35 - 80 grams of Salvia miltiorrhiza, 10 - 20 grams of Panax notoginseng, 3 - 10 grams of Hirudo, 10 - 25 grams of Angelica sinensis, 15 - 35 grams of Rehmannia glutinosa, 6 - 15 grams of Arisaema cum Bile, 5 - 10 grams of Platycodon grandiflorus, 6 - 25 grams of Pheretima, 6 - 15 grams of Poria cocos, 35 - 100 grams of Astragalus membranaceus, 5 - 15 grams of Bupleurum chinense, 10 - 35 grams of Gynostemma pentaphyllum.

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