A composition capable of removing prickly heat, soothing and relieving itching and its preparation method

Abstract

The present invention relates to the technical field of antipruritic compositions, and discloses a composition with the functions of dispelling prickly heat, soothing and relieving itching, and a preparation method thereof. The preparation method comprises four steps: synergistic enhancement treatment of plant extracts, co-crystallization stabilization protection treatment, multi-carrier differentiated embedding treatment, and final preparation of a composite preparation. By establishing a synergistic enhancement treatment method of plant extracts such as calendula, Poria cocos, Portulaca oleracea, and aloe vera, and using co-crystal technology to improve the stability of active ingredients, and adopting a differentiated embedding strategy to eliminate competitive embedding interference, the technical effects of significantly improving the efficacy of dispelling prickly heat, soothing and relieving itching, greatly improving the stability of active ingredients, and optimizing the consistency of efficacy release are achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of preparation of antipruritic compositions, and more particularly to a composition capable of dispelling prickly heat, soothing and relieving itching, and a preparation method thereof. Background Art

[0002] Topical preparations for relieving prickly heat and soothing itching are widely used in summer skin care. Compound formulations containing multiple plant extracts, in particular, hold significant market value. Prior art preparations for these products typically utilize simple physical mixing processes, directly blending the plant extracts and other active ingredients with a matrix material.

[0003] However, there are three key technical problems with existing preparation technologies: first, there is a lack of effective synergistic enhancement processing technology between plant extracts, and each component acts independently, resulting in the overall anti-prickly heat, soothing and anti-itching effects failing to achieve optimal results; second, plant active ingredients have poor stability during the preparation and storage process and are prone to degradation and inactivation, affecting the sustainability of the product's efficacy; third, multiple plant components exhibit competitive binding when encapsulated and protected using carrier materials, resulting in uneven encapsulation efficiency and large differences in the release rates of different components, affecting the synergy of efficacy. Summary of the Invention

[0004] In order to solve the above technical problems, the present invention provides a composition having the functions of dispelling prickly heat, soothing and relieving itching, and a preparation method thereof.

[0005] Among them, a method for preparing a composition capable of removing prickly heat, soothing and relieving itching comprises the following steps:

[0006] Step 1: Take calendula extract, Poria extract, Portulaca oleracea extract, and Aloe vera extract, and divide them into two groups, A and B, for treatment. Group A contains calendula extract and Poria extract, and the mass ratio is controlled at 9.5:1. Group B contains Portulaca oleracea extract and Aloe vera extract, and the mass ratio is controlled at 2:5. Group A is mixed and reacted at 40-45°C for 15 minutes to form a calendula-Poria oleracea synergistic enhancer. Group B is mixed and reacted under the same conditions for 15 minutes to form a Portulaca oleracea-Aloe vera synergistic enhancer.

[0007] Step 2: The Calendula-Poria Cocos synergist of Group A was mixed with glycerol and butylene glycol in a mass ratio of 1:24:30, heated to 60-65°C for dissolution, and then cooled to 25°C at a cooling rate of 2°C / min to obtain a Calendula-Poria Cocos eutectic complex; the Portulaca Oleracea-Aloe Vera synergist of Group B was similarly mixed with glycerol and butylene glycol in a mass ratio of 1:24:30, and the Portulaca Oleracea-Aloe Vera eutectic complex was obtained using the same process;

[0008] Step 3: The Calendula-Poria cocos eutectic complex is spray-dried and embedded using maltodextrin as a carrier, and the Portulaca oleracea-Aloe eutectic complex is fluidized-bed coated using hydrogenated lecithin as a carrier to obtain differentially embedded plant active ingredient particles;

[0009] Step 4: Emulsify and homogenize the differentially encapsulated plant active ingredient particles with water, menthol, p-hydroxyacetophenone, PEG-40 hydrogenated castor oil, ammonium acryloyldimethyltaurate / VP copolymer, 1,2-hexanediol, jojoba seed oil, essence, disodium EDTA, potassium sorbate, and sorbic acid to obtain a prickly heat, soothing, and antipruritic composition.

[0010] Preferably, the content of calendula officinalis extract is 0.19%, the content of Poria cocos extract is 0.02%, the content of Portulaca oleracea extract is 0.02%, and the content of aloe vera extract is 0.05%.

[0011] Preferably, the total glycerol content used for the eutectic treatment of group A and group B is 4.52%, and the total butanediol content is 5.60%, wherein the glycerol content used for each group treatment is 2.26%, and the butanediol content is 2.80%.

[0012] Preferably, the inlet air temperature of the spray drying and embedding is 180°C, and the outlet air temperature is 80°C, forming microcapsules with a particle size of 5-15 microns.

[0013] Preferably, the temperature of the fluidized bed coating is 60° C., forming embedded particles with a coating thickness of 2-5 μm.

[0014] Preferably, the content of maltodextrin is 0.05%, and the content of hydrogenated lecithin is 0.05%.

[0015] Preferably, the speed of emulsification and homogenization is 3000-5000 rpm, and the homogenization time is 10-15 minutes.

[0016] Preferably, the water content is 85.69% and the menthol content is 0.50%.

[0017] Preferably, the content of p-hydroxyacetophenone is 0.50%.

[0018] A composition with the effects of removing prickly heat, soothing and relieving itching is prepared by the above method.

[0019] The beneficial effects of the present invention are:

[0020] Significantly improved synergistic effect: The plant extract synergistic effect processing technology establishes a deep synergistic relationship between plant ingredients such as calendula, Poria cocos, Portulaca oleracea, and aloe vera, enabling various plant active ingredients to promote each other and coordinate their effects. The overall prickly heat, soothing and antipruritic effect is significantly improved compared to the traditional simple mixing process, achieving a synergistic effect of 1+1+1+1>4.

[0021] The stability of active ingredients is greatly improved: The co-crystallization stabilization protection treatment technology changes the crystal structure of plant active ingredients and embeds the active molecules in the glycerol-butylene glycol lattice, effectively protecting the active ingredients from external factors such as light, oxidation, and temperature. The thermal stability and chemical stability of the active ingredients are 3-5 times higher than those of the original plant extracts, and the product storage stability is significantly improved.

[0022] Optimization of efficacy release consistency: Multi-carrier differentiated encapsulation processing technology eliminates competitive encapsulation interference among plant ingredients. By matching carrier materials and encapsulation conditions for different plant ingredients, it ensures that various active ingredients can obtain sufficient and uniform encapsulation protection. The release rates of various plant ingredients tend to be consistent, and the synergy and sustainability of efficacy are significantly improved.

[0023] Innovative breakthrough in preparation process: The triple technology fusion process realizes full-process technological innovation from plant synergistic enhancement, stability protection to controlled-release optimization, providing a new technical path for the preparation of external skin care preparations, breaking through the technical limitations of traditional simple mixing processes.

[0024] Stable and controllable product quality: Through precise control of step-by-step processing and differentiated encapsulation, the consistency and reproducibility of product quality between batches are significantly improved, providing reliable technical support for industrial production, and fundamentally improving the stability and controllability of product quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a stability comparison diagram in the present invention.

[0026] Figure 2 It is a comparison diagram of release consistency in the present invention.

[0027] Figure 3 It is the comprehensive performance radar chart of the present invention. DETAILED DESCRIPTION

[0028] The subject matter described herein will now be discussed with reference to example embodiments. It should be understood that these embodiments are discussed solely to enable those skilled in the art to better understand and implement the subject matter described herein, and that the functions and arrangements of the elements discussed may be varied without departing from the scope of this specification. Various examples may omit, substitute, or add various processes or components as needed. Furthermore, features described in some examples may be combined in other examples.

[0029] At least one embodiment of the present invention discloses a method for preparing a composition capable of dispelling prickly heat, soothing and relieving itching, comprising the following steps:

[0030] Step 1: Take calendula extract, Poria extract, Portulaca oleracea extract, and Aloe vera extract, and divide them into two groups, A and B, for treatment. Group A contains calendula extract and Poria extract, and the mass ratio is controlled at 9.5:1. Group B contains Portulaca oleracea extract and Aloe vera extract, and the mass ratio is controlled at 2:5. Group A is mixed and reacted at 40-45°C for 15 minutes to form a calendula-Poria oleracea synergistic enhancer. Group B is mixed and reacted under the same conditions for 15 minutes to form a Portulaca oleracea-Aloe vera synergistic enhancer.

[0031] Step 2: The Calendula-Poria Cocos synergist of Group A was mixed with glycerol and butylene glycol in a mass ratio of 1:24:30, heated to 60-65°C for dissolution, and then cooled to 25°C at a cooling rate of 2°C / min to obtain a Calendula-Poria Cocos eutectic complex; the Portulaca Oleracea-Aloe Vera synergist of Group B was similarly mixed with glycerol and butylene glycol in a mass ratio of 1:24:30, and the Portulaca Oleracea-Aloe Vera eutectic complex was obtained using the same process;

[0032] Step 3: The Calendula-Poria cocos eutectic complex is spray-dried and embedded using maltodextrin as a carrier, and the Portulaca oleracea-Aloe eutectic complex is fluidized-bed coated using hydrogenated lecithin as a carrier to obtain differentially embedded plant active ingredient particles;

[0033] Step 4: Emulsify and homogenize the differentially encapsulated plant active ingredient particles with water, menthol, p-hydroxyacetophenone, PEG-40 hydrogenated castor oil, ammonium acryloyldimethyltaurate / VP copolymer, 1,2-hexanediol, jojoba seed oil, essence, disodium EDTA, potassium sorbate, and sorbic acid to obtain a prickly heat, soothing, and antipruritic composition.

[0034] in:

[0035] The content of calendula extract is 0.19%, the content of Poria cocos extract is 0.02%, the content of Portulaca oleracea extract is 0.02%, and the content of aloe vera extract is 0.05%.

[0036] The total glycerol content used for the co-crystallization treatment of Group A and Group B was 4.52%, and the total butanediol content was 5.60%, of which the glycerol content used for each group treatment was 2.26% and the butanediol content was 2.80%.

[0037] The inlet air temperature of the spray drying encapsulation is 180°C and the outlet air temperature is 80°C, forming microcapsules with a particle size of 5-15 microns.

[0038] The temperature of the fluidized bed coating was 60°C, forming embedded particles with a coating thickness of 2-5 μm.

[0039] The content of maltodextrin is 0.05% and the content of hydrogenated lecithin is 0.05%.

[0040] The speed of emulsification and homogenization is 3000-5000 rpm, and the homogenization time is 10-15 minutes.

[0041] The water content is 85.69% and the menthol content is 0.50%.

[0042] The content of p-hydroxyacetophenone is 0.50%.

[0043] At least one embodiment of the present invention discloses a composition capable of removing prickly heat, soothing and relieving itching, which is prepared by the above method.

[0044] At least one embodiment of the present invention discloses a method for preparing a composition capable of dispelling prickly heat, soothing and relieving itching, comprising the following steps:

[0045] Step 1: Synergistic treatment of plant extracts;

[0046] Take calendula extract 0.19%, Poria extract 0.02%, Portulaca oleracea extract 0.02%, Aloe vera extract 0.05%;

[0047] First, the four plant extracts were divided into two groups for treatment based on the characteristics of the active ingredients and the interaction patterns of each plant extract:

[0048] Group A: Calendula officinalis extract and Poria cocos extract, the mass ratio was controlled at 9.5:1;

[0049] Group B: Portulaca oleracea extract and Aloe vera extract, the mass ratio was controlled at 2:5.

[0050] This grouping is based on the chemical affinity and complementary mechanism of action between plant active ingredients.

[0051] The two groups of plant extracts were treated with synergistic enhancement:

[0052] For group A: Calendula officinalis extract and Poria cocos extract were mixed and reacted at 40-45°C for 15 minutes to form a synergistic enhancer of Calendula officinalis and Poria cocos;

[0053] For group B: the purslane extract and the aloe vera extract were mixed and reacted at 40-45° C. for 15 minutes to form a purslane-aloe vera synergistic enhancer.

[0054] Through this grouping process, a synergistic combination of the two plant extracts was obtained, providing the base material for subsequent co-crystallization. The key significance of this grouping process is to respect the interaction between the different plant components, avoiding the interference and antagonism that may occur when all the components are mixed; and providing the base material for subsequent co-crystallization.

[0055] Step 2: Eutectic stabilization protection treatment;

[0056] The purpose of this step is to improve the stability of plant active ingredients through co-crystallization technology. The two plant extract synergists obtained in step 1 are co-crystallized with glycerol and butylene glycol respectively:

[0057] For Group A Calendula-Poria Cocos synergistic enhancer:

[0058] Using a controlled crystallization method, the synergist was mixed with 2.26% glycerol and 2.80% butylene glycol in a mass ratio of 1:24:30. The mixture was heated and dissolved at 60-65°C to form a uniform mixed solution. The solution was then slowly cooled to 25°C at a rate of 2°C / minute. During the cooling process, hydrogen bonds and van der Waals forces formed between the plant active ingredients and the glycerol and butylene glycol molecules, spontaneously assembling to form an ordered eutectic structure, resulting in a Calendula-Poria cocos eutectic complex.

[0059] For Group B Purslane-Aloe Vera Synergist:

[0060] Using the same controlled crystallization method, the synergistic enhancer was mixed with 2.26% glycerol and 2.80% butanediol in a mass ratio of 1:24:30. The mixture was heated to dissolve at 60-65°C and then cooled to 25°C at a cooling rate of 2°C / min to obtain a purslane-aloe eutectic complex.

[0061] During the co-crystallization process, different groups of plant active ingredients are embedded in the glycerol-butylene glycol lattice, which changes the original molecular arrangement and significantly improves the thermal and chemical stability of the active ingredients. Both co-crystal complexes have a regular crystal structure, and the stability of the active ingredients is 3-5 times higher than that of the original plant extracts.

[0062] To ensure the purity and stability of the eutectic complex, the two eutectic complexes were handled separately throughout the preparation process to avoid mutual interference between different components.

[0063] Step 3: Differentiated embedding treatment of multiple carriers;

[0064] The purpose of this step is to achieve the best embedding protection effect based on the differences in the physical and chemical properties of different eutectic complexes. Based on the physical and chemical properties of the two different eutectic complexes obtained in step 2, a differentiated embedding strategy is adopted:

[0065] For the Calendula-Poria cocos eutectic complex, maltodextrin (0.05%) was used as a carrier material due to its strong hydrophilicity and excellent high-temperature stability. A spray-drying encapsulation method was used, with an inlet air temperature of 180°C and an outlet air temperature of 80°C, to form microcapsules with a particle size of 5-15 microns. This encapsulation method fully protects the active ingredients in the Calendula-Poria cocos eutectic complex and ensures excellent release kinetics from the skin surface.

[0066] For the Portulaca oleracea-Aloe Vera co-crystal complex, due to its high content of fat-soluble active ingredients and its high heat sensitivity, 0.05% hydrogenated lecithin was used as a carrier material. Fluidized bed coating was used at 60°C to form encapsulated particles with a coating thickness of 2-5 microns. This encapsulation method provides enhanced lipid affinity protection for the active ingredients in the Portulaca oleracea-Aloe Vera co-crystal complex, ensuring their ability to penetrate deep into the skin and exert their effects.

[0067] Through differentiated selection of carrier materials and precise control of the encapsulation process, competition between different botanical ingredients for the same carrier is avoided, ensuring that each botanical ingredient is fully encapsulated and protected. This differentiated encapsulation process achieves an encapsulation efficiency of over 95% for each active ingredient, significantly improving the consistency of release rates.

[0068] The essence of this multi-carrier differentiated encapsulation treatment technology is to "tailor" the physical and chemical properties of different plant eutectic complexes, selecting the most suitable carrier material and encapsulation conditions for each complex, so as to achieve the optimal protection effect and release characteristics.

[0069] Step 4: Final preparation of the compound preparation;

[0070] The differentiated embedded plant active ingredient particles obtained in step 3 were compounded with other formula ingredients: 85.69% water, 1.00% PEG-40 hydrogenated castor oil, 1.00% ammonium acryloyldimethyltaurate / VP copolymer, 0.54% 1,2-hexanediol, 0.50% p-hydroxyacetophenone, 0.50% menthol, 0.18% jojoba seed oil, 0.05% flavor, 0.03% disodium EDTA, 0.008% potassium sorbate, and 0.002% sorbic acid were added according to the formula ratio.

[0071] An emulsification and homogenization process is adopted, and homogenization is performed at a rotation speed of 3000-5000 rpm for 10-15 minutes to obtain a prickly heat, soothing and antipruritic composition with a uniform texture.

[0072] In order to verify the effectiveness of the technical solution of the present invention, the following five experiments were designed to demonstrate the technical effect:

[0073] 1. Synergistic enhancement verification experiment: verify the effect of plant extract synergistic enhancement treatment technology.

[0074] 2. Stability test experiment: verify the effect of eutectic stabilization protection treatment technology.

[0075] 3. Release consistency test: Verify the effectiveness of the multi-carrier differentiated embedding processing technology.

[0076] 4. Process innovation comparison experiment: verify the innovative breakthrough of the preparation process.

[0077] 5. Product quality stability test: verify the stability and controllability of product quality.

[0078] Experiment 1: Synergistic Efficiency Verification Experiment

[0079] Experimental purpose: To verify the efficacy improvement effect of plant extract grouping synergistic enhancement technology compared with the traditional simple mixing process.

[0080] Experimental steps:

[0081] 1. Prepare the control group: Use the traditional simple mixing process to directly mix the calendula extract, Poria extract, Portulaca oleracea extract, and Aloe extract in the same proportion.

[0082] 2. Preparation of experimental groups: Using the group synergistic treatment technology of the present invention, the plant extracts were divided into group A (Calendula officinalis extract and Poria cocos extract, mass ratio 9.5:1) and group B (Purslane extract and Aloe vera extract, mass ratio 2:5) and treated separately.

[0083] 3. Efficacy test: In vitro anti-inflammatory activity test and antioxidant activity test were used to evaluate the efficacy of the two groups of samples.

[0084] 4. Anti-inflammatory activity test: Using the TNF-α-induced HaCaT cell inflammation model, the release of IL-6 and IL-8 inflammatory factors was measured.

[0085] 5. Antioxidant activity test: DPPH free radical scavenging rate assay and ABTS free radical scavenging rate assay were used.

[0086] Experimental results:

[0087]

[0088] Experiment 2: Stability test experiment

[0089] Experimental purpose: To verify the effect of eutectic stabilization protection treatment technology on improving the stability of plant active ingredients.

[0090] Experimental steps:

[0091] 1. Preparation of control group: The composition was directly prepared using the original plant extract.

[0092] 2. Preparation of experimental groups: Two groups of synergistic enhancers were treated separately using grouped eutectic stabilization and protection technology to prepare Calendula-Poria cocos eutectic complex and Portulaca oleracea-Aloe eutectic complex.

[0093] 3. Stability test conditions: Store under accelerated stability test conditions at 40°C ± 2°C and relative humidity 75% ± 5%.

[0094] 4. Testing time points: 0 days, 30 days, 60 days, 90 days, 180 days, 360 days.

[0095] 5. Testing indicators: active ingredient content retention rate, appearance change, pH value change.

[0096] 6. Analytical method: High performance liquid chromatography (HPLC) was used to determine the content of the main active ingredient.

[0097] Experimental results:

[0098]

[0099] Comparison of appearance and pH stability:

[0100]

[0101] Experiment 3: Release consistency test

[0102] Experimental purpose: To verify the effect of multi-carrier differentiated encapsulation technology on improving the release consistency of plant ingredients.

[0103] Experimental steps:

[0104] 1. Prepare the control group: All plant components were embedded in a uniform carrier material (maltodextrin).

[0105] 2. Preparation of experimental group: Using multi-carrier differentiated encapsulation technology, the Calendula-Poria cocos eutectic complex was encapsulated with maltodextrin, and the Portulaca oleracea-Aloe eutectic complex was encapsulated with hydrogenated lecithin.

[0106] 3. Release test: Franz diffusion cell method was used to simulate skin penetration using artificial skin membrane.

[0107] 4. Test conditions: Temperature 37°C ± 0.5°C, receiving solution phosphate buffer (pH 7.4).

[0108] 5. Sampling time points: 0.5h, 1h, 2h, 4h, 6h, 8h, 12h, 24h. 6. Detection method: The cumulative release of each plant active ingredient was determined by ultraviolet spectrophotometry.

[0109] Experimental results:

[0110]

[0111]

[0112] Comparison of embedding efficiency:

[0113]

[0114] Experiment 4: Process Innovation Comparative Experiment

[0115] Experimental purpose: To verify the comprehensive technical advantages of the triple technology fusion process compared with the traditional preparation process.

[0116] Experimental steps:

[0117] 1. Preparation of traditional process composition: Prepared by simple physical mixing process.

[0118] 2. Preparation of innovative process compositions: Prepared using the triple technology fusion process of the present invention (group synergistic enhancement treatment, group eutectic stabilization protection treatment, and multi-carrier differentiated embedding treatment).

[0119] 3. Comprehensive performance testing: including efficacy testing, stability testing, and quality consistency testing.

[0120] 4. Production efficiency assessment: record indicators such as preparation time, energy consumption, and yield rate.

[0121] 5. Cost-benefit analysis: Calculate raw material utilization, waste generation, and overall costs.

[0122] Experimental results:

[0123]

[0124] See Figure 1 Stability comparison chart.

[0125] See Figure 2 Release consistency comparison chart.

[0126] See Figure 3 Comprehensive performance radar chart.

[0127] Experiment 5: Product quality stability test

[0128] Experimental purpose: To verify the improvement effect of the preparation process of the present invention on the stability and controllability of product quality.

[0129] Experimental steps:

[0130] 1. Batch preparation: 10 batches of products were prepared using both traditional and innovative processes (using group synergistic enhancement treatment, group eutectic stabilization protection treatment, and multi-carrier differentiated embedding treatment).

[0131] 2. Quality testing: Each batch is fully tested for quality, including content determination, physical and chemical indicators, and microbiological indicators.

[0132] 3. Statistical analysis: Calculate the mean, standard deviation, and relative standard deviation (RSD) of each indicator.

[0133] 4. Consistency evaluation: The coefficient of variation was used to evaluate the consistency between batches.

[0134] 5. Long-term stability tracking: Conduct 12-month stability tracking tests on the product.

[0135] Experimental results:

[0136] Comparison of consistency between batches:

[0137]

[0138] Comparison of production qualification rate:

[0139]

[0140] Long-term stability tracking results:

[0141]

[0142] Experimental Conclusion

[0143] Through the above five systematic experiments, it is verified that the technical solution of the present invention has achieved remarkable technical effects:

[0144] Significant improvement in synergistic effect: The synergistic effect enhancement technology of plant extracts increases the comprehensive efficacy index by 48.0%, and the anti-inflammatory and antioxidant activities are both increased by more than 45%.

[0145] The stability of active ingredients has been greatly improved: the eutectic stabilization protection treatment technology has increased the 12-month retention rate of active ingredients from 52.7% to 82.1%, and the stability has been increased by 1.6 times.

[0146] Optimization of efficacy release consistency: Multi-carrier differentiated encapsulation processing technology reduces the coefficient of variation of plant ingredient release rate from 22.8% to 1.4%, and the encapsulation efficiency is increased by an average of 21.8%.

[0147] Innovative breakthrough in preparation technology: The triple technology fusion process has achieved more than 30% improvement in key indicators such as prickly heat relief effect, antipruritic effect, and stability.

[0148] Product quality is stable and controllable: the consistency between batches has improved by an average of 78.1%, and the production qualification rate has increased from 87.6% to 99.3%, providing reliable guarantees for industrial production.

[0149] The above describes an embodiment of the present invention, but this embodiment is not limited to the above-mentioned specific implementation methods. The above-mentioned specific implementation methods are merely illustrative and not restrictive. Ordinary technicians in this field can also make more forms of equivalent embodiments based on the inspiration of this embodiment, all of which are protected by this embodiment.

Claims

1. A method for preparing a composition having the functions of removing prickly heat, soothing and relieving itching, characterized in that: The following steps are involved: Step 1: Take calendula extract, Poria extract, Portulaca oleracea extract and aloe extract, and divide them into two groups A and B for treatment. Group A contains calendula extract and Poria extract, and the mass ratio is controlled at 9.5:

1. Group B contains Portulaca oleracea extract and aloe extract, and the mass ratio is controlled at 2:

5. Group A is mixed and reacted at 40-45°C for 15 minutes to form a calendula-Poria oleracea synergistic enhancer. Group B is mixed and reacted under the same conditions for 15 minutes to form a Portulaca oleracea-aloe synergistic enhancer. Step 2: The Calendula-Poria Cocos synergist of Group A was mixed with glycerol and butylene glycol in a mass ratio of 1:24:30, heated to 60-65°C for dissolution, and then cooled to 25°C at a cooling rate of 2°C / min to obtain a Calendula-Poria Cocos eutectic complex; the Portulaca Oleracea-Aloe Vera synergist of Group B was similarly mixed with glycerol and butylene glycol in a mass ratio of 1:24:30, and the Portulaca Oleracea-Aloe Vera eutectic complex was obtained using the same process; Step 3: The Calendula-Poria cocos eutectic complex is spray-dried and embedded using maltodextrin as a carrier, and the Portulaca oleracea-Aloe eutectic complex is fluidized-bed coated using hydrogenated lecithin as a carrier to obtain differentially embedded plant active ingredient particles; Step 4: Emulsify and homogenize the differentiated encapsulated plant active ingredient particles with water, menthol, p-hydroxyacetophenone, PEG-40 hydrogenated castor oil, ammonium acryloyldimethyltaurate / VP copolymer, 1,2-hexanediol, jojoba seed oil, essence, disodium EDTA, potassium sorbate and sorbic acid to obtain a prickly heat, soothing and antipruritic composition.

2. The method for preparing a composition for removing prickly heat, soothing and relieving itching according to claim 1, wherein: The content of the calendula extract is 0.19%, the content of the Poria cocos extract is 0.02%, the content of the purslane extract is 0.02%, and the content of the aloe vera extract is 0.05%.

3. The method for preparing a composition for removing prickly heat, soothing and relieving itching according to claim 1, wherein: The total glycerol content used for the co-crystallization treatment of Group A and Group B was 4.52%, and the total butanediol content was 5.60%, of which the glycerol content used for each group treatment was 2.26% and the butanediol content was 2.80%.

4. The method for preparing a composition having the functions of removing prickly heat, soothing and relieving itching according to claim 1, wherein: The inlet air temperature of the spray drying and embedding is 180° C., and the outlet air temperature is 80° C., forming microcapsules with a particle size of 5-15 microns.

5. The method for preparing a composition having the functions of removing prickly heat, soothing and relieving itching according to claim 1, wherein: The fluidized bed coating temperature is 60° C., forming embedded particles with a coating thickness of 2-5 μm.

6. The method for preparing a composition for removing prickly heat, soothing and relieving itching according to claim 1, wherein: The content of the maltodextrin is 0.05%, and the content of the hydrogenated lecithin is 0.05%.

7. The method for preparing a composition for removing prickly heat, soothing and relieving itching according to claim 1, characterized in that: The rotation speed of the emulsification homogenization is 3000-5000 rpm, and the homogenization time is 10-15 minutes.

8. The method for preparing a composition for removing prickly heat, soothing and relieving itching according to claim 1, wherein: The water content is 85.69%, and the menthol content is 0.50%.

9. The method for preparing a composition for removing prickly heat, soothing and relieving itching according to claim 1, wherein: The content of the p-hydroxyacetophenone is 0.50%.

10. A composition for removing prickly heat, soothing and relieving itching, characterized in that: Prepared by the method according to any one of claims 1 to 9.

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