Scalp oil control composition for preventing alopecia seborrhoeica as well as preparation method and application of scalp oil control composition

Abstract

The invention relates to the technical field of daily chemicals, and particularly discloses a scalp oil control composition for preventing alopecia seborrhoeica as well as a preparation method and application of the scalp oil control composition. The scalp oil control composition is prepared from the following main components: nicotinamide, capryloyl glycine, piralinone ethanolamine salt, betaine salicylic acid, lemon peel extract, white willow bark extract and rice fermentation filtrate. All the components have a synergistic effect, and the effects of controlling oil, protecting hair and preventing alopecia seborrhoeica are achieved. The preparation method disclosed by the invention is simple and convenient, and the obtained product is high in bioavailability of active ingredients, good in hair care effect and low in irritation, has the effects of caring hair, strengthening hair roots, regulating scalp micro-ecology and preventing seborrheic alopecia, and can be widely applied to related washing and care products for preventing seborrheic alopecia.

Description

Technical Field

[0001] This invention belongs to the field of daily chemical products technology, specifically relating to a scalp oil-controlling composition for preventing seborrheic alopecia, its preparation method, and its application. Background Technology

[0002] Seborrheic alopecia is a common type of hair loss, characterized by excessive sebum secretion on the scalp. It is caused by a combination of factors, including androgen imbalance, increased sebaceous gland sensitivity, scalp microecological disturbance, and genetic factors. Excessive sebum clogs hair follicles, causing inflammation, ultimately leading to thinning and hair loss, severely impacting the patient's appearance and mental health. Currently available topical shampoos, hair growth sprays, and oral medications have significant limitations: topical shampoos have low retention rates, limited hair growth effects, significant individual differences, and require long-term maintenance; oral medications are not considered cosmetics and must be taken under a doctor's guidance, posing a risk of side effects, and most products only target a single aspect, failing to address the root cause of the problem.

[0003] CN202510503053.3 discloses a traditional Chinese medicine composition for scalp care and its preparation method and application, comprising the following raw materials: 8-15 parts ginseng, 20-30 parts arborvitae leaves, 12-20 parts prepared Polygonum multiflorum, 15-25 parts Salvia miltiorrhiza, 18-28 parts Eclipta prostrata, and 10-16 parts Ligusticum chuanxiong. This invention uses the above-mentioned raw materials to obtain a traditional Chinese medicine extract as the effective ingredient in the shampoo. Although it has a certain theoretical basis in terms of composition and has a certain oil-controlling and hair loss-preventing effect, its effective ingredients are all traditional Chinese medicine extracts, which are relatively greatly affected by the origin and season of the medicinal plants. Furthermore, the extraction process is complex, which has a certain impact on the extraction efficiency. While the focus is on the hair loss prevention effect, it fails to address the key breakthrough in solving the problem of hair loss that plagues modern society from the perspective of oil control mechanisms. Therefore, the effect is not long-lasting or the hair loss prevention effect is not ideal.

[0004] CN202111465869.X discloses a multi-functional scalp care composition, its preparation method, and its application. This composition mainly comprises polyols, Sophora flavescens extract, Lepidium apetalum root extract, keratin, sugar alcohols, hydroxyphenylpropionamide benzoic acid, creatine, panthenol, and nicotinamide. Although this scalp care composition contains multiple active ingredients, their main functions are moisturizing and conditioning the hair. However, it fails to comprehensively address the hair loss mechanism and lacks technological breakthroughs in promoting absorption, thus limiting the product's efficacy.

[0005] CN201710843581.9 discloses a nourishing shampoo with the following components by weight ratio: edible white vinegar: 10-20 parts; tea oil: 15-30 parts; beeswax: 16-20 parts; water: 40-60 parts; soybean saponin: 5-9 parts; salicylic acid: 10-20 parts; benzyl alcohol: 10-20 parts; processed Polygonum multiflorum extract: 10-12 parts. This formula contains a high amount of salicylic acid, while the permitted level of salicylic acid in cosmetics is 3.0%. Furthermore, the dissolution or dispersion of the 16-20 parts of beeswax in this component ratio presents some technical challenges. Moreover, the 15-30 parts of tea oil do not effectively address hair cleaning and scalp oil control during shampooing. Additionally, the large amount of salicylic acid in this composition poses a high risk of product stability and irritation.

[0006] Existing technologies suffer from several drawbacks: unsatisfactory oil control and hair loss prevention effects, low utilization rate of active ingredients, and the use of salicylic acid in some formulations to synergistically soften keratin and promote the absorption of active substances, which carries the risk of irritation. Furthermore, they fail to address the prevention or treatment of seborrheic alopecia, a prevalent condition in modern society. This invention proposes a novel scalp oil-control composition for preventing seborrheic alopecia. Summary of the Invention

[0007] Therefore, the purpose of this invention is to overcome the shortcomings of the prior art and provide a scalp oil-control composition for preventing seborrheic alopecia, its preparation method, and its application. The aim is to solve key technical problems existing in scalp care compositions, such as unsatisfactory oil control and anti-hair loss effects, low utilization rate of active ingredients, and the risk of irritation from salicylic acid.

[0008] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0009] In a first aspect, the present invention provides a scalp oil-control composition for preventing seborrheic alopecia, characterized in that, by weight, it comprises the following components: 3.0-10.0 parts of nicotinamide, 0.5-5.0 parts of capryloyl glycine, 0.3-1.0 parts of piroctone olamine salt, 0.5-3.0 parts of betaine salicylic acid, 1.0-8.0 parts of lemon peel extract, 1.0-5.0 parts of white willow bark extract, and 5.0-50.0 parts of rice fermentation filtrate.

[0010] Preferably, the scalp oil-controlling composition comprises, by weight, the following components: 5.0-10.0 parts nicotinamide, 3.0-5.0 parts capryloyl glycine, 0.5-1.0 parts piroctone olamine salt, 1.5-3.0 parts betaine salicylic acid, 4.0-8.0 parts lemon peel extract, 3.0-5.0 parts white willow bark extract, and 25.0-50.0 parts rice fermentation filtrate. Preferably, the scalp oil-controlling composition further comprises appropriate amounts of excipients, including one or more of moisturizers, penetration enhancers, thickeners, preservatives, and pH adjusters.

[0011] Preferably, the moisturizing agent is at least one selected from betaine, low-molecular-weight sodium hyaluronate, and ceramide. Betaine has a synergistic effect on the dissolution and absorption of betaine salicylate; the low-molecular-weight sodium hyaluronate was purchased from Nano, a product of Bloomage Biotechnology Co., Ltd. Enzymatically cleaved oligomeric sodium hyaluronate, with a molecular weight of less than 10 kDa, exhibits high safety and bioactivity. It can be absorbed transdermally to the epidermis and dermis, providing deep hydration, repairing damaged cells, scavenging free radicals, improving skin elasticity, reducing wrinkles, and exerting anti-aging effects. Ceramides protect the scalp barrier. The thickener is at least one selected from carbomer, xanthan gum, guar gum, or polyquaternium-10.

[0012] Preferably, the penetration enhancer is at least one of menthol, PEG-60 hydrogenated castor oil, or lauryl azone. The penetration enhancer in the formulation improves the transdermal absorption efficiency of the active ingredient by altering the structure or physicochemical environment of the stratum corneum. Menthol increases lipid fluidity and relaxes the connections between keratinocytes, forming more open penetration channels. PEG-60 hydrogenated castor oil, as a nonionic surfactant, enhances the dissolution and diffusion of the active ingredient in the stratum corneum by solubilizing oil components, reducing interfacial tension, and forming a microemulsion system. Lauryl azone reduces the diffusion resistance of the active ingredient by interfering with the lipid arrangement of the stratum corneum, lowering the lipid phase transition temperature, and increasing fluidity.

[0013] Preferably, the preservative is at least one of phenoxyethanol, caprylyl glycol, sodium benzoate, and ethylhexylglycerin, or a commonly used cosmetic preservative.

[0014] Niacinamide can promote scalp blood circulation, replenish the scalp with energy, and deliver sufficient nutrients to hair follicles. Simultaneously, it can regulate sebum secretion and maintain normal hair follicle function, thereby reducing hair loss caused by malnutrition. Furthermore, niacinamide can improve scalp microcirculation, enhance the vitality and repair ability of scalp cells, and indirectly reduce the irritation of salicylic acid on the scalp.

[0015] Caprylyl glycine has a significant oil-controlling effect, which can regulate the function of scalp sebaceous glands, reduce sebum secretion, reduce dandruff production, and keep the scalp clean.

[0016] When used in combination with other ingredients, piroctone olamine salt can synergistically enhance oil control, further inhibit scalp sebum secretion, and improve dandruff removal ability, keeping the scalp fresh for a long time.

[0017] Betaine and salicylic acid soften the stratum corneum, helping to remove excess dead skin cells from the scalp, facilitating the penetration and absorption of other active ingredients and improving their utilization rate. They also deeply cleanse dirt and oil from hair follicles and have anti-inflammatory and antibacterial effects, achieving a synergistic effect of dandruff removal, stratum corneum softening, moisturizing, and promoting the penetration and absorption of active substances. Betaine and salicylic acid combine the gentle, moisturizing properties of betaine with the oil-controlling, skin-softening, antibacterial, and anti-inflammatory effects of salicylic acid, while helping to maintain the skin barrier. Furthermore, it overcomes the drawbacks of salicylic acid, such as strong exfoliation, high irritation, and poor solubility.

[0018] Lemon peel extract contains flavonoids, vitamins, and other active ingredients that can regulate sebaceous gland secretion, inhibit bacterial and fungal growth, and reduce inflammation. Its antioxidant properties also protect scalp cells from free radical damage, thus reducing dandruff. Simultaneously, its excellent soothing and anti-inflammatory effects can reduce scalp irritation caused by the betaine and salicylic acid in the formula, exhibiting a synergistic effect.

[0019] White willow bark extract works through multiple mechanisms. Its components, such as salicin, have anti-inflammatory, analgesic, and soothing effects. When used in combination with betaine and salicylic acid, it can provide the exfoliating effect of salicylic acid, promote scalp metabolism, and enhance the absorption of active ingredients. At the same time, it can also help regulate scalp sebum secretion, reduce inflammation, help remove dead skin cells, soothe and moisturize the scalp, and improve scalp discomfort.

[0020] Rice fermentation filtrate contains trace components of natural rice grains and can synergistically enhance the effects of other ingredients through various mechanisms. It helps regulate sebum secretion, deeply cleanses the scalp, replenishes the scalp with nutrients and moisture, strengthens the scalp barrier function, and also possesses antibacterial and anti-inflammatory properties, thus effectively promoting scalp health and further improving overall oil control, hair loss prevention, and hair care effects. The amino acids and polysaccharides in rice fermentation filtrate replenish the scalp with moisture and nutrients, enhance the scalp barrier function, improve the scalp's resistance, and reduce external environmental irritation. Furthermore, the bifida ferment filtrate and its fermentation active components in the natural fermentation filtrate also play a role in regulating the scalp's microecology.

[0021] Secondly, the present invention provides a method for preparing a scalp oil-controlling composition for preventing seborrheic alopecia, comprising the following steps:

[0022] (1) Weigh out nicotinamide, capryloyl glycine, piroctone ethanolamine salt, betaine salicylic acid, lemon peel extract, white willow bark extract, rice fermentation filtrate and excipients in proportion;

[0023] (2) Mix the deionized water required by the formula and the thickener, heat, stir and dissolve completely to obtain mixture A;

[0024] (3) Add nicotinamide, capryloyl glycine, and piroctone ethanolamine salt to mixture A and stir until completely dissolved to obtain mixture B;

[0025] (4) Add appropriate amounts of moisturizer, penetration enhancer, and betaine salicylic acid to mixture B, stir until completely dissolved, and obtain solution C;

[0026] (5) Add lemon peel extract, white willow bark extract and rice fermentation filtrate to mixture C, stir until well mixed, and obtain solution D;

[0027] (6) Add preservatives and pH adjusters, and stir until the mixture is uniform to obtain the scalp oil control composition.

[0028] Preferably, in step (2), the deionized water should be sterile production water, and its addition amount is 10-20 times that of the thickener. The stirring temperature is 30-60℃ and the stirring rate is 35-60r / min.

[0029] Preferably, in step (4), the amount of penetration promoter added is 0.5-2.0 parts, and the stirring temperature is 55-60℃.

[0030] Preferably, the stirring temperature in step (5) is 45-48℃, and the stirring rate is 35-60 r / min. Thirdly, the scalp oil-controlling composition of the present invention can be used to prepare hair care products for preventing seborrheic alopecia, such as shampoos, conditioners, and scalp nutrient solutions.

[0031] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0032] (1) The synergistic effect of ingredients such as nicotinamide, capryloyl glycine, and piroctone ethanolamine salt works by regulating sebum secretion, antibacterial and anti-inflammatory effects, and improving the nutritional supply to hair follicles. It can quickly reduce the accumulation of scalp oil and create a healthy growth environment for hair follicles, achieving the dual effects of oil control and hair loss prevention, and the effect is long-lasting and stable.

[0033] (2) By modifying salicylic acid to betaine salicylic acid, compared to the direct use of salicylic acid in existing technologies, the risks of poor solubility and easy precipitation of salicylic acid and the irritation risk of pure salicylic acid are reduced from the source. Betaine salicylic acid can soften the stratum corneum of the scalp and promote the penetration and absorption of active ingredients such as nicotinamide and capryloyl glycine; at the same time, moisturizers, penetration enhancers and betaine salicylic acid form a synergistic system, further improving the solubility of betaine salicylic acid or the bioavailability of each active ingredient, ensuring that the effective ingredients can play a full role.

[0034] (3) By utilizing the soothing and anti-inflammatory effects of lemon peel extract and white willow bark extract, as well as the strengthening and repairing effects of rice fermentation filtrate and nicotinamide on the scalp barrier, a multi-irritant protection mechanism is formed, which significantly reduces the risk of product irritation to the scalp, making it suitable even for sensitive skin.

[0035] (4) This composition has comprehensive effects and can be widely used in various hair care products such as shampoos, conditioners, and scalp nourishing solutions for preventing seborrheic alopecia. Its preparation method is simple, requires no special equipment, is easy to industrialize, and has good industrialization prospects. Detailed Implementation

[0036] To more clearly illustrate the purpose, technical solution, and beneficial effects of this invention, the technical solution of this invention will be fully described below in conjunction with specific embodiments. It should be noted that the embodiments described herein are only some embodiments of this invention, not all embodiments. Based on these embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this invention. Furthermore, unless otherwise specified, the experimental methods used in the specific embodiments are conventional experimental methods; and unless otherwise specified, the materials and reagents used can be obtained commercially.

[0037] Example 1

[0038] A scalp oil-control composition for preventing seborrheic alopecia, comprising, by weight, the following components: 3.0 parts nicotinamide, 0.5 parts capryloyl glycine, 0.3 parts piroctone olamine salt, 0.5 parts betaine salicylic acid, 1.0 part lemon peel extract, 1.0 part white willow bark extract, 5.0 parts rice fermentation filtrate, 1.0 part betaine (moisturizer), 0.5 parts carbomer (thickener), 0.5 parts menthol (penetration enhancer), 0.8 parts phenoxyethanol (preservative), 0.2 parts pH adjuster, and 10.0 parts deionized water.

[0039] Preparation method:

[0040] (1) Weigh each component according to the above-mentioned weight proportions;

[0041] (2) Mix deionized water and carbomer, heat, stir and dissolve completely to obtain mixture A;

[0042] (3) Add nicotinamide, capryloyl glycine, and piroctone ethanolamine salt to mixed solution A and stir until completely dissolved to obtain mixed solution B;

[0043] (4) Add the moisturizing agent betaine, the penetration enhancer menthol and betaine salicylic acid to the mixture B, stir until completely dissolved, and obtain solution C;

[0044] (5) Add lemon peel extract, white willow bark extract and rice fermentation filtrate to mixture C, stir until well mixed, and obtain solution D;

[0045] (6) Add phenoxyethanol and pH adjuster, and stir until the mixture is uniform to obtain the scalp oil control composition.

[0046] Example 2

[0047] A scalp oil-control composition for preventing seborrheic alopecia, comprising, by weight, the following components: 5.0 parts nicotinamide, 3.0 parts capryloyl glycine, 0.5 parts piroctone olamine salt, 1.5 parts betaine salicylic acid, 4.0 parts lemon peel extract, 3.0 parts white willow bark extract, 25.0 parts rice fermentation filtrate, 2.0 parts sodium hyaluronate (a humectant), 1.0 part xanthan gum (a thickener), 1.0 part PEG-60 hydrogenated castor oil (a penetration enhancer), 0.6 parts phenoxyethanol (a preservative), 0.3 parts sodium benzoate, 0.3 parts pH adjuster, and 15.0 parts deionized water.

[0048] Preparation method:

[0049] (1) Weigh each component according to the above-mentioned weight proportions;

[0050] (2) Mix deionized water and xanthan gum, heat, stir and dissolve completely to obtain mixture A;

[0051] (3) Add nicotinamide, capryloyl glycine, and piroctone ethanolamine salt to mixed solution A and stir until completely dissolved to obtain mixed solution B;

[0052] (4) Add the moisturizing agent sodium hyaluronate, the penetration enhancer PEG-60 hydrogenated castor oil and betaine salicylic acid to the mixture B, stir until completely dissolved, and obtain solution C;

[0053] (5) Add lemon peel extract, white willow bark extract and rice fermentation filtrate to mixture C, stir until well mixed, and obtain solution D;

[0054] (6) Add phenoxyethanol, sodium benzoate and pH adjuster, and stir until evenly mixed to obtain the scalp oil control composition.

[0055] Example 3

[0056] A scalp oil-control composition for preventing seborrheic alopecia, comprising, by weight, the following components: 10.0 parts nicotinamide, 5.0 parts capryloyl glycine, 1.0 part piroctone olamine salt, 3.0 parts betaine salicylic acid, 8.0 parts lemon peel extract, 5.0 parts white willow bark extract, 50.0 parts rice fermentation filtrate, 3.0 parts ceramide (moisturizer), 1.8 parts guar gum (thickener), 2.0 parts laurocapram (penetration enhancer), 0.7 parts ethylhexylglycerin (preservative), 0.4 parts pH adjuster, and 18.0 parts deionized water.

[0057] Preparation method:

[0058] (1) Weigh each component according to the above-mentioned weight proportions;

[0059] (2) Mix deionized water and guar gum, heat, stir and dissolve completely to obtain mixture A;

[0060] (3) Add nicotinamide, capryloyl glycine, and piroctone ethanolamine salt to mixed solution A and stir until completely dissolved to obtain mixed solution B;

[0061] (4) Add the moisturizing agent ceramide, the penetration enhancer lauryl azone and the betaine salicylic acid to the mixture B, stir until completely dissolved, and obtain solution C;

[0062] (5) Add lemon peel extract, white willow bark extract and rice fermentation filtrate to mixture C, stir until well mixed, and obtain solution D;

[0063] (6) Add ethylhexylglycerin and pH adjuster, and stir until the mixture is uniform to obtain the scalp oil control composition.

[0064] Comparative Example 1

[0065] A composition, compared to Example 2, lacks nicotinamide and is replaced with an equal amount of deionized water.

[0066] Comparative Example 2

[0067] A composition, compared to Example 2, lacks capryloylglycine and is replaced with an equal amount of deionized water.

[0068] Comparative Example 3

[0069] A composition, compared to Example 2, lacks piroctone ethanolamine salt and is replaced with an equal amount of deionized water.

[0070] Comparative Example 4

[0071] A composition, compared to Example 2, lacks betaine salicylic acid and is replaced with an equal amount of deionized water.

[0072] Comparative Example 5

[0073] A composition, compared to Example 2, lacks lemon peel extract and is replaced with an equal amount of deionized water.

[0074] Comparative Example 6

[0075] A composition, compared to Example 2, lacks the white willow bark extract and is replaced with an equal amount of deionized water.

[0076] Comparative Example 7

[0077] A composition, compared to Example 2, lacks lemon peel extract and white willow bark extract, and replaces them with an equal amount of deionized water.

[0078] Comparative Example 8

[0079] A composition, compared to Example 2, lacks rice fermentation filtrate and is replaced with an equal amount of deionized water.

[0080] Oil control effect test

[0081] The test was conducted using a skin oil analyzer. Volunteers with a tendency towards seborrheic alopecia and excessive scalp oil secretion were randomly divided into 11 groups of 10 people each. Each group used the scalp oil-controlling compositions (used in shampoo form) prepared in Examples 1-3 and Comparative Examples 1-8 of this invention. The oil content of each group's scalp was measured before use and after 2 and 4 weeks of use. The average value was taken, and the results are shown in Table 1.

[0082] Anti-hair loss effect test

[0083] The hair loss counting method was used. Volunteers with a tendency for seborrheic alopecia were randomly divided into 11 groups of 10 each. Each group used the scalp oil-controlling compositions (used as shampoo) prepared in Examples 1-3 and Comparative Examples 1-8 of this invention. For the first 3 days of product use, and after 2 and 4 weeks of use, shed hair was collected in a fixed container each time the volunteers shampooed. After drying, broken hairs shorter than 5cm were removed, and the number of remaining long hairs was counted. The number of hairs lost in each group was measured, and the average value was taken. The results are shown in Table 2.

[0084] Active ingredient utilization efficiency test

[0085] The Franz diffusion cell method was employed. Pig ear skin was used as a permeation barrier, fixed between the supply and receiving chambers of the Franz diffusion cell. Phosphate buffer was added to the receiving chamber as the receiving medium. Appropriate amounts of the compositions from Examples 1-3 and Comparative Examples 1-8 were added to the supply chamber, and experiments were conducted at 32°C and a stirring rate of 300 rpm. Samples were taken from the receiving chamber at 2 h, 4 h, and 6 h, and the contents of nicotinamide and capryloyl glycine in the samples were detected by high-performance liquid chromatography (HPLC). Each sample was tested three times, and the average value was taken. The cumulative permeation was calculated; a higher cumulative permeation indicated a higher utilization rate of the active ingredient. The results are shown in Table 3.

[0086] Stimulation effect test

[0087] Human skin patch testing was conducted, referring to the relevant methods in the "Cosmetic Safety Technical Specifications" (2015 edition). Eligible volunteers were randomly divided into 11 groups of 10 each, using the scalp oil-control compositions prepared in Examples 1-3 and Comparative Examples 1-8 of this invention. The composition (in the form of a 10% aqueous solution) was added dropwise to the drug chamber of the patch applicator at a volume of 0.020-0.025 mL. The patch applicator was then applied to the flexor surface of the volunteer's forearm for 24 hours. After removing the patch applicator, skin reactions were observed at 30 min, 24 h, and 48 h, and scored according to the skin reaction grading standard (0-4 points). Each volunteer was scored once at each time point; the average reaction score for each group was recorded. In addition, the transepidermal water loss of the scalp was measured after 4 weeks of product use in each group, and the average value was taken. Lower transepidermal water loss indicated better scalp barrier function and less irritation. The results are shown in Table 4.

[0088] Hair care effect test

[0089] The validation was conducted through hair tensile strength and hair shine tests. Volunteers with a tendency towards seborrheic alopecia were randomly divided into 11 groups of 10 each, and used the scalp oil-controlling compositions (used in shampoo form) prepared in Examples 1-3 and Comparative Examples 1-8 of this invention, respectively. The hair tensile strength test was performed using a hair strength tester to measure the breaking strength of the hair; the hair shine test was performed using a shine meter to measure the gloss of the hair surface. Tests were conducted on each group of volunteers before use and after 4 weeks of use, and the average values ​​were taken. The results are shown in Figure 5.

[0090] Test Results

[0091] Table 1. Oil control effect test results

[0092]

[0093]

[0094] The core of this invention lies in its four-dimensional oil-control system, formed by regulating sebum secretion with nicotinamide, inhibiting sebum production with capryloyl glycine, enhancing oil control with piroctone ethanolamine salt, and promoting penetration and absorption with betaine and salicylic acid. This results in the oil-control effects of Examples 1-3 being significantly superior to the comparative examples. Comparative Example 1, due to the reduction in nicotinamide, showed relatively poor performance in promoting circulation and nutrient supply, with an oil content of 40.3 μg / cm² after 4 weeks. Comparative Example 2, due to the reduction in capryloyl glycine, had relatively insufficient sebum secretion inhibition, with an oil content of 42.5 μg / cm² after 4 weeks. 2 In Comparative Example 4, due to the lack of betaine and salicylic acid, the penetration of the active ingredients was also reduced, resulting in a slightly weaker oil-controlling effect. After 4 weeks, the oil content reached 43.8 μg / cm³. 2 Comparative samples 5-7 lacked lemon peel extract and / or white willow bark extract, resulting in a deficiency in the oil-controlling effect of the selected plant ingredients and a decrease in oil-controlling efficacy.

[0095] Table 2 Results of Anti-Hair Loss Effect Test

[0096]

[0097] The anti-hair loss effect is directly related to the anti-inflammatory and nutritional supply functions of the ingredients. Niacinamide, a core component of hair follicle nutrition, resulted in 31.7 hairs lost in 4 weeks in Comparative Example 1 due to its absence, twice that of Example 2. Capryloyl glycine not only controls oil but also reduces hair follicle damage caused by sebum blockage; its absence in Comparative Example 2 resulted in 30.5 hairs lost in 4 weeks. Notably, Comparative Example 7, lacking lemon peel extract and white willow bark extract, lost its plant-assisted anti-inflammatory and soothing effects, and the hair follicle inflammation could not be effectively controlled, resulting in 30.3 hairs lost in 4 weeks. This further demonstrates the important role of the plant-based lemon peel extract and white willow bark extract in the anti-hair loss system.

[0098] Table 3 Results of Active Ingredient Utilization Rate Test (Cumulative Penetration / (μg / cm³)) 2 ))

[0099]

[0100] Comparative Example 4, lacking betaine and salicylic acid, showed a cumulative nicotinamide permeation of only 13.9 μg / cm³ over 6 hours. 2 Example 2 (28.3 μg / cm) 2The penetration of nicotinamide and capryloyl glycine decreased by 49.1%, demonstrating the key role of betaine salicylic acid in opening the stratum corneum barrier. In Examples 1-3, the penetration of nicotinamide and capryloyl glycine was higher than that of Comparative Examples 1-8, fully verifying the penetration-enhancing effect and synergistic effect of betaine salicylic acid. Appropriate amounts of betaine salicylic acid can fully open the stratum corneum channels, and combined with the soothing effects of lemon peel extract and white willow bark extract, achieve a balanced effect of "penetration enhancement and low irritation".

[0101] Table 4 Results of the Stimulant Effect Test

[0102]

[0103] Examples 1-3 showed low average response scores and minimal transepidermal water loss after 4 weeks of use, indicating good scalp barrier function and low irritation. Comparative Example 4, lacking betaine and salicylic acid, exhibited lower irritation; however, the results showed that the penetration of nicotinamide and capryloyl glycine was correspondingly lower due to the absence of betaine and salicylic acid's penetration-enhancing effect. Comparative Example 5, lacking lemon peel extract, and Comparative Example 6, lacking white willow bark extract, showed higher average response scores and greater transepidermal water loss, demonstrating that the present invention effectively reduces the risk of product irritation through the combination of various active ingredients and reasonable ingredient ratio adjustments. Comparative Example 7, lacking both lemon peel extract and white willow bark extract, lost its dual soothing and anti-inflammatory effects, resulting in a significantly higher 24-hour average response score compared to Example 2, further validating the crucial role of the two plant extracts in reducing irritation.

[0104] Table 5. Results of hair care effect test

[0105]

[0106]

[0107] After 4 weeks of use, the hair breakage strength and shine of Examples 1-3 were superior to those of the comparative examples, indicating that the hair care effect of Examples 1-3 was better than that of the comparative examples 1-9. The comparative examples, due to the lack of certain active ingredients or mismatched ingredient ratios, could not synergistically exert their nourishing and hair-care effects, resulting in poor hair care effects. In the scalp oil-control composition for preventing seborrheic alopecia of the present invention, the active ingredients exhibit a synergistic effect. Examples 1-3 all demonstrate good oil control and anti-hair loss effects, with high utilization rate of active ingredients, low irritation, and good hair care effects.

[0108] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A scalp oil-controlling composition for preventing seborrheic alopecia, characterized in that, The product comprises, by weight, the following components: nicotinamide 3.0-10.0 parts, capryloyl glycine 0.5-5.0 parts, piroctone olamine salt 0.3-1.0 parts, betaine salicylic acid 0.5-3.0 parts, lemon peel extract 1.0-8.0 parts, white willow bark extract 1.0-5.0 parts, and rice fermentation filtrate 5.0-50.0 parts.

2. The scalp oil-controlling composition for preventing seborrheic alopecia according to claim 1, characterized in that, It also includes appropriate excipients, which include one or more of the following: humectants, penetration enhancers, thickeners, preservatives, and pH adjusters.

3. The scalp oil-controlling composition for preventing seborrheic alopecia according to claim 2, characterized in that, The moisturizer is at least one of betaine, sodium hyaluronate with small molecules, and ceramide; the thickener is at least one of carbomer, xanthan gum, guar gum, and polyquaternium-10; the penetration enhancer is at least one of menthol, PEG-60 hydrogenated castor oil, or lauryl acetone; and the preservative is at least one of phenoxyethanol, caprylyl glycol, sodium benzoate, and ethylhexylglycerin, or a commonly used cosmetic preservative.

4. The scalp oil-controlling composition for preventing seborrheic alopecia according to claim 1, characterized in that, The product comprises, by weight, the following components: nicotinamide 5.0-10.0 parts, capryloyl glycine 3.0-5.0 parts, piroctone olamine salt 0.5-1.0 parts, betaine salicylic acid 1.5-3.0 parts, lemon peel extract 4.0-8.0 parts, white willow bark extract 3.0-5.0 parts, and rice fermentation filtrate 25.0-50.0 parts.

5. The method for preparing the scalp oil-controlling composition according to any one of claims 1-4, characterized in that, Includes the following steps: (1) Weigh out nicotinamide, capryloyl glycine, piroctone ethanolamine salt, betaine salicylic acid, lemon peel extract, white willow bark extract, rice fermentation filtrate and excipients in proportion; (2) Mix the deionized water required by the formula and the thickener, heat, stir and dissolve completely to obtain mixture A; (3) Add nicotinamide, capryloyl glycine, and piroctone ethanolamine salt to mixture A and stir until completely dissolved to obtain mixture B; (4) Add appropriate amounts of moisturizer, penetration enhancer, and betaine salicylic acid to mixture B, stir until completely dissolved, and obtain solution C; (5) Add lemon peel extract, white willow bark extract and rice fermentation filtrate to mixture C, stir until well mixed, and obtain solution D; (6) Add preservatives and pH adjusters, and stir until the mixture is uniform to obtain the scalp oil control composition.

6. The preparation method according to claim 5, characterized in that, In step (2), the deionized water should be sterile production water, and its addition amount should be 10-20 times that of the thickener. The stirring temperature should be 30-60℃ and the stirring rate should be 35-60r / min.

7. The preparation method according to claim 5, characterized in that, In step (4), the amount of penetration enhancer added is 0.5-2.0 parts, and the stirring temperature is 55-60℃.

8. The preparation method according to claim 5, characterized in that, In step (5), the stirring temperature is 45-48℃ and the stirring rate is 35-60r / min.

9. The use of the scalp oil-control composition according to any one of claims 1-4 in the preparation of a shampoo and conditioner for preventing seborrheic alopecia.

10. The application according to claim 9, characterized in that, The hair care products mentioned are any one of shampoo, conditioner, and scalp nourishing solution.

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