Method for promoting healthy growth of hair and application thereof

Abstract

The invention discloses a method for promoting healthy growth of hair, which is characterized in that by activating hair follicles, inducing hair growth factors, enhancing the anchoring effect of hair follicle cells on the hair, activating the resting period of the hair follicles and prolonging the growing period of the hair follicles, the hair follicles can stably provide nutrient substances for the hair for a long time, and the healthy and continuous growth of the hair is promoted. By adopting the synergistic effect of the hydroxyferriheme and the carboxymethyl modified deacetylated chitin, the health state of hair can be improved, the thickness and diameter of the hair are increased, and the whole hair is in a water-light health state. And the mass ratio of the hydroxyferriheme to the carboxymethyl modified deacetylated chitin is (2-3): (9-10), so that synthesis of globin can be stimulated, the water content of scalp cuticle is increased, trancutaneous dehydration and film formation on the surface of hair are inhibited, and the influence of ultraviolet rays and adverse environments is avoided. Meanwhile, the hydrolyzed yeast protein and the hydrolyzed corn protein have a synergistic effect, so that cells are promoted to differentiate into hair follicles and proliferate, and hair regeneration and strong anchoring of hair roots are facilitated.

Description

Technical Field

[0001] This invention relates to a method for promoting healthy hair growth and its application, specifically to the field of medical or cosmetic products. Background Technology

[0002] With the development of technology and the improvement of people's living standards, competition for work and survival is becoming increasingly fierce. Increased life pressure leads to changes in hormone levels in the body, resulting in deteriorating skin conditions and hair loss. After hair loss begins, people gradually experience anxiety and tension, which further exacerbates hair loss, eventually leading to total baldness or "male pattern baldness" (or "Mediterranean" hair loss). Currently available hair regrowth products are slow to show results and require long-term use to see any effect. During use, users may experience a state of urgent anxiety, and this emotional imbalance may further aggravate hair loss. In addition, some hair regrowth products are irritating and have a pungent smell, limiting their application. Therefore, how to take measures to inhibit and treat hair loss in its early stages and restore healthy hair is an important issue that needs to be addressed.

[0003] Chinese invention patent CN202010788299.7 discloses a hair loss prevention and hair growth liquid and its preparation method. It utilizes pyrrolidine diaminopyrimidine oxide with extracts of traditional Chinese medicines such as ginseng, ginger, arborvitae leaves, and angelica to achieve a significant effect in promoting hair growth. It is less likely to cause scalp sensitivity and inflammation, and exhibits no excessive hair loss, sediment, or suspended matter. However, the introduction of these extracts gives the product a slightly pungent odor, limiting its application. Chinese invention patent CN202011454283.9 discloses a nanocomposition with hair loss prevention, hair growth, hair strengthening, and hair darkening functions, along with its preparation method and application. This nanocomposition is formed by combining pyrrolidine diaminopyrimidine oxide, hair growth peptides, hair strengthening peptides, hair darkening peptides, and a cell permeabilizer. It exhibits good transdermal properties, allowing deep penetration into hair follicles and improving bioavailability, enabling even low concentrations of anti-hair loss active ingredients to exert excellent anti-hair loss effects. However, the preparation process for this nanocomposition is complex, and its stability is low. Prolonged storage can lead to precipitation and separation, affecting the product's effectiveness. Summary of the Invention

[0004] In order to improve the hair growth efficiency of hair growth products and reduce the irritation caused by using the products, the first aspect of the present invention provides a method for promoting healthy hair growth, which activates hair follicles, induces hair growth factors, strengthens the anchoring effect of hair follicle cells on hair, activates the resting phase of hair follicles, prolongs the growth phase of hair follicles, and enables hair follicles to provide nutrients to hair in a long-term and stable manner, thereby promoting healthy and continuous hair growth.

[0005] A second aspect of the present invention provides a method for promoting healthy hair growth, comprising the following steps: (1) Add deionized water, solubilizer, cooling agent and antioxidant to a mixing container and stir until well mixed; (2) Add the active ingredients and stir well to obtain a reagent that promotes healthy hair growth; (3) Apply the hair growth promoting agent obtained in step 2 to the hair roots and spread it evenly with your fingertips until absorbed. (4) Apply 2-3 times a day. The effect will appear after 2-3 months of use.

[0006] In a preferred embodiment, the active ingredients in step 2 include, by weight percentage, 0.1-5% pyrimidine oxide, 1-2% hydrolyzed protein, 1.6-2.4% amino acids, 0.05-0.1% fermentation product, and 0.1-2% biotin.

[0007] In a preferred embodiment, the pyrimidine oxide comprises pyrrolidinyl diaminopyrimidine oxide and diaminopyrimidine oxide, wherein the weight ratio of the pyrrolidinyl diaminopyrimidine oxide to the diaminopyrimidine oxide is (0.1-5):(0.2-1.5).

[0008] In a preferred embodiment, the active ingredients in step 2 further include hydroxyheme and modified natural polysaccharide, wherein the weight ratio of hydroxyheme to modified natural polysaccharide is (0.05-5):(1-15).

[0009] In a preferred embodiment, the weight ratio of the hydroxyheme to the modified natural polysaccharide is (0.1-5):(5-10).

[0010] In a preferred embodiment, the weight ratio of the hydroxyheme to the modified natural polysaccharide is 2.5:7.

[0011] In a preferred embodiment, the modified natural polysaccharide is selected from one or a combination of modified chitin, modified deacetylated chitin, and modified cellulose.

[0012] In a preferred embodiment, the modified natural polysaccharide is modified deacetylated chitosan; more preferably, the modified natural polysaccharide is carboxymethyl modified deacetylated chitosan.

[0013] The synergistic effect of hydroxyheme and carboxymethyl-modified deacetylated chitosan can improve hair health, increase hair thickness and diameter, and give hair an overall healthy, glossy appearance. This may be because hydroxyheme contains a large amount of hemoglobin, which can promote NMF biosynthesis and inhibit porphyrin synthesis. Its synergistic effect with carboxymethyl-modified deacetylated chitosan can effectively reduce the infiltration of inflammatory cells, control the growth of bacteria and fungi, and thus exert anti-inflammatory and anti-itch effects, promoting effective infection prevention, increasing scalp collagen deposition, and providing sufficient healthy nutrition for hair. The applicant further discovered that a mass ratio of (2-3):(9-10) of hydroxyheme to carboxymethyl-modified deacetylated chitosan can maintain long-term hair health, improve hair immunity, and reduce environmental damage to hair. The possible reason is that, at a mass ratio of (2-3):(9-10), hydroxyheme and carboxymethyl modified deacetylated chitosan can stimulate the synthesis of globin, increase the water content of the scalp stratum corneum, inhibit transepidermal water loss, and continuously replenish water and nutrients for the hair. Furthermore, it can form a film on the hair surface, protecting it from ultraviolet rays and adverse environmental effects, thus maintaining the long-term health of the hair. Simultaneously, it promotes autophagy, breaking down aging cells into smaller molecules, further providing nutrients for hair growth.

[0014] In a preferred embodiment, the fermentation product is selected from one or a combination of several of the following: yeast fermentation products, Lactobacillus plantarum fermentation extract, Bifidobacterium longum lysate, and schistosome.

[0015] In a preferred embodiment, the fermentation product is schistosome.

[0016] In a preferred embodiment, the amino acid is selected from one or a combination of several of leucine, isoleucine, alanine, valine, and arginine.

[0017] In a preferred embodiment, the amino acid is L-arginine.

[0018] In a preferred embodiment, the hydrolyzed protein comprises a combination of hydrolyzed yeast protein and hydrolyzed corn protein, wherein the weight ratio of the hydrolyzed yeast protein to the hydrolyzed corn protein is (0.5-1.5):(0.5-1.5).

[0019] In a preferred embodiment, the weight ratio of the hydrolyzed yeast protein to the hydrolyzed corn protein is (0.5-1):(0.5-1).

[0020] In a preferred embodiment, the weight ratio of the hydrolyzed yeast protein to the hydrolyzed corn protein is 1:1.

[0021] In a preferred embodiment, the hydrolyzed corn protein is a hydrolyzed corn protein oligopeptide.

[0022] In a preferred embodiment, the biotin is a group B vitamin, selected from high molecular weight, medium molecular weight, and low molecular weight, preferably vitamin B7.

[0023] In a preferred embodiment, the cosolvent is glycerol, the cooling agent is menthol, and the antioxidant is γ-carotene.

[0024] In a preferred embodiment, the glycerol is 1-5% by weight, the menthol is 0.1-0.5% by weight, the γ-carotene is 1-5% by weight, and the balance is made up with deionized water.

[0025] A second aspect of the invention provides an application of a method for promoting healthy hair growth, applied to the repair of hair follicles.

[0026] Compared with the prior art, the present invention has the following beneficial effects: (1) The method for promoting healthy hair growth described in this invention uses the synergistic effect of hydroxyheme and carboxymethyl modified deacetylated chitosan to improve the health of hair, increase hair thickness and diameter, and make the hair present a healthy and glossy appearance.

[0027] (2) The method for promoting healthy hair growth described in this invention uses a mass ratio of (2-3): (9-10) of hydroxyheme and carboxymethyl modified deacetylated chitin to stimulate the synthesis of globin, increase the water content of the scalp stratum corneum, inhibit transepidermal water loss, form a film on the hair surface to protect it from the effects of ultraviolet rays and adverse environments, and at the same time promote cell autophagy to supplement nutrients for healthy hair growth.

[0028] (3) The method for promoting healthy hair growth described in this invention uses hydrolyzed yeast protein and hydrolyzed corn protein in a weight ratio of (0.5-1.5):(0.5-1.5), which can upregulate the adhesion between cells and cell matrix, promote cell differentiation into hair follicles, and promote proliferation, which helps hair regeneration and strong anchoring of hair roots. Detailed Implementation

[0029] Example 1 A method to promote healthy hair growth includes the following steps: (1) Add deionized water, solubilizer, cooling agent and antioxidant to a mixing container and stir until well mixed; (2) Add the active ingredients and stir well to obtain a reagent that promotes healthy hair growth; (3) Apply the hair growth promoting agent obtained in step 2 to the hair roots and spread it evenly with your fingertips until absorbed. (4) Apply twice a day. The effects will appear after 2 months of use.

[0030] The active ingredients in step 2, by weight percentage, include 4% pyrimidine oxide, 1.5% hydrolyzed protein, 2.1% amino acids, 0.075% fermentation product, 1.2% biotin, 2.5% hydroxyheme, and 7% modified natural polysaccharide.

[0031] The substances in step 1, by weight percentage, include 2.5% cosolvent, 0.3% cooling agent, 2% antioxidant, and deionized water to make up the balance.

[0032] The pyrimidine oxides include pyrrolidinyl diaminopyrimidine oxide and diaminopyrimidine oxide in a weight ratio of 3:1.

[0033] The modified natural polysaccharide is carboxymethyl modified deacetylated chitosan.

[0034] The fermentation product is schistosome.

[0035] The amino acid in question is L-arginine.

[0036] The hydrolyzed protein comprises a combination of hydrolyzed yeast protein and hydrolyzed corn protein in a weight ratio of 1:1. The hydrolyzed corn protein is a hydrolyzed corn protein oligopeptide.

[0037] The biotin is vitamin B7.

[0038] The solubilizer is glycerin, the cooling agent is menthol, and the antioxidant is γ-carotene.

[0039] Example 2 A method for promoting healthy hair growth, with the same steps as in Example 1, except that the modified natural polysaccharide is carboxymethyl cellulose.

[0040] Example 3 A method for promoting healthy hair growth, with the same steps as in Example 1, except that the cosolvent is ethanol.

[0041] Example 4 A method for promoting healthy hair growth, with the same steps as in Example 1, except that the active ingredients in step 2 are 1% hydroxyheme and 3% modified natural polysaccharides by weight percentage.

[0042] Performance testing Stability test: After storing the hair growth promoting reagents prepared in Examples 1-4 at 25°C for 7 days, centrifuge at 5000 rpm for 5 minutes and observe whether there is precipitation; after placing the hair growth promoting reagents prepared in Examples 1-4 at 45°C for 7 days, centrifuge at 5000 rpm for 5 minutes and observe whether there is precipitation; after placing the hair growth promoting reagents prepared in Examples 1-4 at 0°C for 7 days, centrifuge at 5000 rpm for 5 minutes and observe whether there is precipitation.

[0043] The test results are shown in Table 1.

[0044] Table 1

Claims

1. A method for promoting healthy hair growth, characterized in that, By activating hair follicles, inducing hair growth factors, strengthening the anchoring effect of hair follicle cells on hair, activating the resting phase of hair follicles, prolonging the growth phase of hair follicles, and enabling hair follicles to provide nutrients to hair in a long-term and stable manner, thus promoting healthy and continuous hair growth.

2. The method for promoting healthy hair growth according to claim 1, characterized in that, Includes the following steps: (1) Add deionized water, solubilizer, cooling agent and antioxidant to a mixing container and stir until well mixed; (2) Add the active ingredients and stir well to obtain a reagent that promotes healthy hair growth; (3) Apply the hair growth promoting agent obtained in step 2 to the hair roots and spread it evenly with your fingertips until absorbed. (4) Apply 2-3 times a day. The effect will appear after 2-3 months of use.

3. The method for promoting healthy hair growth according to claim 2, characterized in that, The active ingredients in step 2, by weight percentage, include 0.1-5% pyrimidine oxide, 1-2% hydrolyzed protein, 1.6-2.4% amino acids, 0.05-0.1% fermentation product, and 0.1-2% biotin.

4. The method for promoting healthy hair growth according to claim 2, characterized in that, The active ingredients in step 2 also include hydroxyheme and modified natural polysaccharides, wherein the weight ratio of hydroxyheme to modified natural polysaccharides is (0.05-5):(1-15).

5. The method for promoting healthy hair growth according to claim 4, characterized in that, The modified natural polysaccharide is selected from one or a combination of modified chitin, modified deacetylated chitin, and modified cellulose.

6. The method for promoting healthy hair growth according to claim 3, characterized in that, The fermentation product is selected from one or a combination of several of the following: yeast fermentation product, Lactobacillus plantarum fermentation extract, Bifidobacterium longum lysate, and schistosome.

7. The method for promoting healthy hair growth according to claim 3, characterized in that, The amino acid is selected from one or a combination of several of leucine, isoleucine, alanine, valine, and arginine.

8. The method for promoting healthy hair growth according to claim 3, characterized in that, The hydrolyzed protein comprises a combination of hydrolyzed yeast protein and hydrolyzed corn protein, wherein the weight ratio of hydrolyzed yeast protein to hydrolyzed corn protein is (0.5-1.5):(0.5-1.5).

9. The method for promoting healthy hair growth according to claim 8, characterized in that, The hydrolyzed corn protein is a hydrolyzed corn protein oligopeptide.

10. The application of a method for promoting healthy hair growth according to any one of claims 1-9, characterized in that, It is used in the repair of hair follicles.

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