Glycyrrhiza and typha angustifolia tooth-strengthening toothpaste and preparation method thereof

Abstract

The toothpaste is prepared from raw materials in percentage by weight as follows: 18%-26% of an abrasive, 0.5%-2% of a thickener, 35%-60% of a humectant, 1%-5% of a foaming agent, 3%-6% of a Chinese herbal medicine composition, 0.1%-0.2% of a preservative and the balance of deionized water. The preparation method comprises the following steps: S1, adding the humectant, the preservative and the deionized water into a reactor, and stirring until the humectant, the preservative and the deionized water are completely dissolved; then adding an abrasive, and performing high-shear dispersion; s2, adding a thickening agent into a system in S1, and stirring to form a uniform colloid; s3, cooling the reaction system in the S2, adding a foaming agent, and stirring until the foaming agent is dissolved; cooling, adding the Chinese herbal medicine extract, and stirring at low speed to obtain paste; s4, homogenizing treatment: transferring the paste into a high-pressure homogenizer, and homogenizing; and degassing to obtain the product. The antibacterial and anti-inflammatory effects of the toothpaste can be remarkably improved, natural extracts are adopted as core components, toxic and side effects are avoided, and oral health can be effectively protected.

Description

Technical Field

[0001] The invention belongs to the technical field of daily chemical products, and in particular relates to a Ganpu tooth-healthy toothpaste and a preparation method thereof. Background Art

[0002] Oral health problems in my country are serious and the prevalence rate is high, mainly manifested in caries, dental plaque, bleeding gums, bad breath, etc. Among them, bacteria and inflammation are the main pathogenic factors causing oral problems. Toothpaste, as a daily necessity, is widely used in oral self-care measures. It is the most basic and effective means to inhibit oral bacteria and inflammation.

[0003] In contemporary society, with the growing demand for safe, green, and healthy lifestyles, Traditional Chinese Medicine (TCM) is increasingly favored by consumers, and is therefore often used as an ingredient in modern cleaning and skincare products. TCM's proven efficacy and mild effects, combined with the absence of significant side effects associated with chemical drugs, have led to the growing popularity of toothpastes containing TCM.

[0004] However, the traditional Chinese medicine toothpaste in the prior art has insufficient antibacterial and anti-inflammatory properties for oral problems and has a poor effect on oral health care. Summary of the Invention

[0005] The object of the present invention is to provide a Ganpu toothpaste and a preparation method thereof, so as to solve the technical problems raised in the above background technology.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] A Ganpu tooth-healthy toothpaste is prepared from the following raw materials in percentage by weight: 18-26% of an abrasive, 0.5-2% of a thickener, 35-60% of a moisturizer, 1-5% of a foaming agent, 3-6% of a Chinese herbal medicine composition, 0.1-0.2% of a preservative, and the balance being deionized water.

[0008] Furthermore, the friction agent is one of calcium carbonate, silicon dioxide and calcium phosphate.

[0009] Furthermore, the thickener is one of sodium carboxymethyl cellulose, sodium hydroxyethyl cellulose, and sodium hydroxypropyl cellulose.

[0010] Furthermore, the moisturizing agent is glycerin or sorbitol.

[0011] Furthermore, the foaming agent is sodium lauryl sulfate or sodium lauryl sulfate.

[0012] Furthermore, the preservative is paraben or sodium benzoate.

[0013] Furthermore, the Chinese medicine composition is made from the following raw materials: sugarcane leaf extract, dandelion extract, murraya oleifera leaf extract, clove flower extract, camellia extract, white ampelopsis extract, and mint extract.

[0014] The extraction method of each extract is as follows: take the corresponding raw materials respectively, drain, grind and wrap with gauze, then put them into a container, extract twice with 8 times the volume of 70% ethanol, reflux at 60°C for 4 hours, filter, remove the filter residue, pour the filtrate into a distillation flask, distill out the ethanol and recover it, and filter the liquid to obtain the extract.

[0015] Furthermore, in the traditional Chinese medicine composition, sugarcane leaf extract, dandelion extract, Murraya osmanthus leaf extract, clove flower extract, camellia extract, white ampelopsis extract, and peppermint extract are mixed in a mass ratio of 3-8:3-8:2-5:1-2:4-6:1-3:1-2.

[0016] Furthermore, in the traditional Chinese medicine composition, sugarcane leaf extract, dandelion extract, Murraya osmanthus leaf extract, clove flower extract, camellia extract, white ampelopsis extract, and peppermint extract are mixed in a mass ratio of 6:6:3:1:5:3:1.

[0017] A method for preparing Ganpu toothpaste comprises the following steps:

[0018] S1: Add moisturizer, preservative and deionized water to the reactor and stir at 600-800 rpm for 10-30 min until completely dissolved; then slowly add the abrasive in 3 portions, with an interval of 2-10 min between each addition, and switch to high shear dispersion at 1200-1500 rpm for 20-60 min, maintaining the system temperature at 50-60°C;

[0019] S2: Add thickener to the system of S1, stir at 600-1000 rpm for 20-40 min, control the temperature at 50-55°C, and form a uniform colloid;

[0020] S3: Cool the reaction system of S2 to 45-50°C, add a foaming agent, and stir at 400-600 rpm for 10-30 minutes until dissolved; cool to 40-45°C, add the Chinese herbal extract, switch to a low speed of 200-400 rpm and stir for 10-30 minutes to obtain a paste;

[0021] S4: Transfer the paste into a high-pressure homogenizer and circulate homogenization at 30-50°C and a pressure of 15-20 MPa for 2-3 times; then degas at a vacuum degree of -0.09 to -0.1 MPa for 10-20 minutes to obtain the paste.

[0022] The raw materials used in the herbal composition of the present invention are:

[0023] Sugarcane leaf extract: Contains natural polyphenols and polysaccharides, which have antioxidant and antibacterial properties and help inhibit the growth of oral bacteria.

[0024] Dandelion Extract: Contains taraxasterols, taraxacin, chlorogenic acid, inulin, and other ingredients. It has broad-spectrum antibacterial properties and inhibits the release of inflammatory factors, alleviating gingival redness, swelling, bleeding, and other inflammatory symptoms. It also enhances the phagocytic function of immune cells and accelerates the resolution of inflammation.

[0025] Murraya Oleracea Leaf Extract: Used in Traditional Chinese Medicine for promoting qi circulation, relieving pain, and detoxifying and reducing swelling, Murraya Oleracea Leaf Extract contains murrayacol, flavonoids, and essential oils, which can inhibit periodontal pathogens. The active ingredients can disrupt the bacterial lipid bilayer structure, synergizing with the core ingredients to enhance antibacterial effects and alleviate pain caused by oral inflammation.

[0026] Lilac flower extract: contains ingredients such as eugenol and clove oil, which can help reduce the amount of preservatives used while enhancing the stability of the formula.

[0027] Camellia extract: Contains tea polyphenols, tea saponins, vitamin E, and other ingredients. It can inhibit bacterial oxidative stress by scavenging free radicals, while also inhibiting bacterial adhesion to tooth surfaces and reducing plaque formation. It also promotes the repair of oral mucosal damage and reduces the likelihood of bacterial infection, thereby providing an anti-inflammatory and restorative effect.

[0028] Bletilla striata extract: contains ingredients such as ampelin and flavonoids, which can reduce gingival bleeding and exudation, and create a microenvironment that is not conducive to bacterial growth; flavonoids have a mild inhibitory effect on some oral pathogens, assisting the core ingredients to enhance the antibacterial effect.

[0029] Mint extract: Contains menthol, menthone, rosmarinic acid and other ingredients, providing a cooling sensation and improving the user experience.

[0030] The beneficial effects of the present invention compared to the prior art are:

[0031] 1. The present invention can significantly improve the antibacterial and anti-inflammatory effects of toothpaste by adding a Chinese herbal medicine composition to the toothpaste. It uses natural extracts as core ingredients, has no toxic side effects, and can effectively protect oral health.

[0032] 2. In the traditional Chinese medicine composition of the present invention, by using sugarcane leaf extract, dandelion extract, Murraya osmanthus leaf extract, clove extract, camellia extract, white peony extract, and mint extract as raw materials, and using sugarcane leaf extract and dandelion extract as core ingredients, the raw materials can interact with each other, synergistically enhance the effect, and jointly improve the antibacterial and anti-inflammatory effects, while having good stability. DETAILED DESCRIPTION

[0033] To make the objectives, technical solutions, and advantages of the present invention more clearly understood, the present invention is further described below with reference to preferred embodiments. However, it should be noted that many of the details listed in this specification are merely intended to help the reader gain a thorough understanding of one or more aspects of the present invention, and these aspects of the present invention can be practiced even without these specific details.

[0034] A Ganpu tooth-healthy toothpaste is prepared from the following raw materials in percentage by weight: 18-26% of an abrasive, 0.5-2% of a thickener, 35-60% of a moisturizer, 1-5% of a foaming agent, 3-6% of a Chinese herbal medicine composition, 0.1-0.2% of a preservative, and the balance being deionized water.

[0035] The friction agent is one of calcium carbonate, silicon dioxide and calcium phosphate.

[0036] The thickener is one of sodium carboxymethyl cellulose, sodium hydroxyethyl cellulose and sodium hydroxypropyl cellulose.

[0037] The moisturizing agent is glycerin or sorbitol.

[0038] The foaming agent is sodium lauryl sulfate or sodium lauryl sulfate.

[0039] The preservative is paraben or sodium benzoate.

[0040] In the traditional Chinese medicine composition, sugarcane leaf extract, dandelion extract, Murraya osmanthus leaf extract, clove flower extract, camellia extract, white ampelopsis extract and mint extract are mixed in a mass ratio of 3-8:3-8:2-5:1-2:4-6:1-3:1-2.

[0041] A method for preparing Ganpu toothpaste comprises the following steps:

[0042] S1: Add moisturizer, preservative and deionized water to the reactor and stir at 600-800 rpm for 10-30 min until completely dissolved; then slowly add the abrasive in 3 portions, with an interval of 2-10 min between each addition, and switch to high shear dispersion at 1200-1500 rpm for 20-60 min, maintaining the system temperature at 50-60°C;

[0043] S2: Add thickener to the system of S1, stir at 600-1000 rpm for 20-40 min, control the temperature at 50-55°C, and form a uniform colloid;

[0044] S3: Cool the reaction system of S2 to 45-50°C, add a foaming agent, and stir at 400-600 rpm for 10-30 minutes until dissolved; cool to 40-45°C, add the Chinese herbal extract, switch to a low speed of 200-400 rpm and stir for 10-30 minutes to obtain a paste;

[0045] S4: Transfer the paste into a high-pressure homogenizer and circulate homogenization at 30-50°C and a pressure of 15-20 MPa for 2-3 times; then degas at a vacuum degree of -0.09 to -0.1 MPa for 10-20 minutes to obtain the paste.

[0046] The following is a more specific example of the invention.

[0047] Example 1

[0048] The invention discloses a Ganpu toothpaste for strengthening teeth, which is prepared from the following raw materials in percentage by weight: 22% calcium carbonate, 0.8% sodium carboxymethyl cellulose, 50% glycerol, 2% sodium lauryl sulfate, 3% Chinese herbal medicine composition, 0.1% paraben, and the balance being deionized water.

[0049] The traditional Chinese medicine composition is prepared by mixing sugarcane leaf extract, dandelion extract, Murraya osmanthus leaf extract, clove flower extract, camellia extract, white ampelopsis extract and mint extract in a mass ratio of 6:6:3:1:5:3:1.

[0050] A method for preparing Ganpu toothpaste comprises the following steps:

[0051] S1: Add the moisturizer, preservative, and deionized water to the reactor and stir at 600 rpm for 10 min until completely dissolved. Then, slowly add the abrasive in three portions, with an interval of 2 min between each addition. Switch to high shear dispersion at 1500 rpm for 60 min, maintaining the system temperature at 55°C.

[0052] S2: Add thickener to the system of S1, stir at 800 rpm for 40 min, and control the temperature at 50°C to form a uniform colloid;

[0053] S3: Cool the reaction system of S2 to 45°C, add the foaming agent, and stir at 500 rpm for 10 minutes until dissolved; cool to 40°C, add the Chinese herbal medicine extract, switch to low-speed stirring at 500 rpm for 15 minutes to obtain a paste;

[0054] S4: Transfer the paste into a high-pressure homogenizer and homogenize it three times at 40°C and a pressure of 10 MPa; then degas at a vacuum of -0.09 MPa for 20 minutes to obtain the paste.

[0055] Example 2

[0056] A Ganpu tooth-healthy toothpaste is prepared from the following raw materials in percentage by weight: 26% calcium phosphate, 0.5% sodium hydroxyethyl cellulose, 55% glycerol, 3% sodium lauryl sulfate, 4% Chinese herbal medicine composition, 0.15% paraben, and the balance is deionized water.

[0057] The traditional Chinese medicine composition is prepared by mixing sugarcane leaf extract, dandelion extract, Murraya osmanthus leaf extract, clove flower extract, camellia extract, white ampelopsis extract and mint extract in a mass ratio of 8:6:5:2:6:3:1.

[0058] A method for preparing Ganpu toothpaste comprises the following steps:

[0059] S1: Add the moisturizer, preservative, and deionized water to the reactor and stir at 700 rpm for 20 min until completely dissolved. Then, slowly add the abrasive in three portions, with an interval of 5 min between each addition. Switch to high shear dispersion at 1300 rpm for 40 min, maintaining the system temperature at 50°C.

[0060] S2: Add thickener to the system of S1, stir at 1000 rpm for 30 min, and control the temperature at 52°C to form a uniform colloid;

[0061] S3: Cool the reaction system of S2 to 48°C, add the foaming agent, and stir at 400 rpm for 20 minutes until dissolved; cool to 43°C, add the Chinese herbal medicine extract, switch to low-speed stirring at 300 rpm for 10 minutes to obtain a paste;

[0062] S4: Transfer the paste into a high-pressure homogenizer and homogenize it three times at 35°C and a pressure of 15 MPa; then degas at a vacuum of -0.1 MPa for 20 minutes to obtain the paste.

[0063] Example 3

[0064] The invention discloses a Ganpu tooth-healthy toothpaste, which is prepared from the following raw materials in percentage by weight: 18% silicon dioxide, 1.5% sodium hydroxyethyl cellulose, 42% glycerol, 1% sodium lauryl sulfate, 3% Chinese herbal medicine composition, 0.2% sodium benzoate, and the balance being deionized water.

[0065] The traditional Chinese medicine composition is prepared by mixing sugarcane leaf extract, dandelion extract, Murraya osmanthus leaf extract, clove flower extract, camellia extract, white ampelopsis extract and mint extract in a mass ratio of 6:8:4:1:3:1:2.

[0066] A method for preparing Ganpu toothpaste comprises the following steps:

[0067] S1: Add the moisturizer, preservative, and deionized water to the reactor and stir at 600 rpm for 30 min until completely dissolved. Then, slowly add the abrasive in three portions, with an interval of 4 min between each addition. Switch to high shear dispersion at 1200 rpm for 30 min, maintaining the system temperature at 58°C.

[0068] S2: Add thickener to the system of S1, stir at 600 rpm for 35 min, and control the temperature at 54°C to form a uniform colloid;

[0069] S3: Cool the reaction system of S2 to 50°C, add the foaming agent, and stir at 400 rpm for 15 minutes until dissolved; cool to 45°C, add the Chinese herbal medicine extract, switch to low-speed stirring at 400 rpm for 25 minutes to obtain a paste;

[0070] S4: Transfer the paste into a high-pressure homogenizer and homogenize it three times at 30°C and a pressure of 18 MPa; then degas at a vacuum of -0.09 MPa for 10 minutes to obtain the paste.

[0071] Example 4

[0072] The invention discloses a Ganpu tooth-healthy toothpaste, which is prepared from the following raw materials in percentage by weight: 20% calcium carbonate, 1% sodium carboxymethyl cellulose, 35% sorbitol, 5% sodium lauryl sulfate, 5% Chinese herbal medicine composition, 0.18% sodium benzoate, and the balance being deionized water.

[0073] The traditional Chinese medicine composition is prepared by mixing sugarcane leaf extract, dandelion extract, Murraya osmanthus leaf extract, clove flower extract, camellia extract, white ampelopsis extract and mint extract in a mass ratio of 7:8:4:2:4:5:1.

[0074] A method for preparing Ganpu toothpaste comprises the following steps:

[0075] S1: Add the moisturizer, preservative, and deionized water to the reactor and stir at 800 rpm for 15 min until completely dissolved. Then, slowly add the abrasive in three portions, with an interval of 10 min between each addition. Switch to high shear dispersion at 1400 rpm for 20 min, maintaining the system temperature at 60°C.

[0076] S2: Add thickener to the system of S1, stir at 700 rpm for 25 min, and control the temperature at 55°C to form a uniform colloid;

[0077] S3: Cool the reaction system of S2 to 46°C, add the foaming agent, and stir at 600 rpm for 30 minutes until dissolved; cool to 42°C, add the Chinese herbal medicine extract, switch to low-speed stirring at 200 rpm for 20 minutes to obtain a paste;

[0078] S4: Transfer the paste into a high-pressure homogenizer and homogenize it three times at 50°C and a pressure of 20 MPa; then degas for 15 minutes at a vacuum of -0.1 MPa to obtain the paste.

[0079] Example 5

[0080] The invention discloses a Ganpu tooth-healthy toothpaste, which is prepared from the following raw materials in percentage by weight: 25% calcium phosphate, 2% sodium carboxymethyl cellulose, 60% glycerol, 4% sodium lauryl sulfate, 6% Chinese herbal medicine composition, 0.16% paraben, and the balance being deionized water.

[0081] In the traditional Chinese medicine composition, sugarcane leaf extract, dandelion extract, Murraya osmanthus leaf extract, clove flower extract, camellia extract, white ampelopsis extract, and mint extract are mixed in a mass ratio of 6:7:1:1:2:3:2.

[0082] A method for preparing Ganpu toothpaste comprises the following steps:

[0083] S1: Add the moisturizer, preservative, and deionized water to the reactor and stir at 800 rpm for 25 min until completely dissolved. Then, slowly add the abrasive in three portions, with an interval of 8 min between each addition. Switch to high shear dispersion at 1500 rpm for 50 min, maintaining the system temperature at 52°C.

[0084] S2: Add thickener to the system of S1, stir at 900 rpm for 20 min, control the temperature at 50°C, and form a uniform colloid;

[0085] S3: Cool the reaction system of S2 to 48°C, add a foaming agent, and stir at 550 rpm for 25 minutes until dissolved; cool to 45°C, add the Chinese herbal extract, and switch to a low-speed stirring of 300 rpm for 30 minutes to obtain a paste;

[0086] S4: Transfer the paste into a high-pressure homogenizer and homogenize it three times at 45°C and a pressure of 12 MPa; then degas for 18 minutes at a vacuum of -0.1 MPa to obtain the paste.

[0087] Comparative Example 1

[0088] The method is basically the same as Example 1, except that no Chinese herbal medicine composition is added to the toothpaste.

[0089] Comparative Example 2

[0090] The method is basically the same as Example 1, except that the sugarcane leaf extract and dandelion extract are not added to the traditional Chinese medicine composition.

[0091] Comparative Example 3

[0092] The method is basically the same as Example 1, except that no sugarcane leaf extract is added to the traditional Chinese medicine composition.

[0093] Comparative Example 4

[0094] The method is basically the same as Example 1, except that no dandelion extract is added to the traditional Chinese medicine composition.

[0095] 1. Antibacterial effect experiment

[0096] 1.1 Antibacterial function experiment

[0097] Referring to 7.5 "Test Method for Antibacterial Effect of Antibacterial Daily Chemical Products (Inhibition Ring Method)" in QB / T 2738-2012, "Evaluation Method for Antibacterial and Antimicrobial Effect of Daily Chemical Products," the toothpastes obtained in Examples 1-5 and Comparative Examples 1-4 were subjected to an inhibition ring test. The experimental bacteria were Staphylococcus aureus, Streptococcus mutans, Porphyromonas gingivalis, and Candida albicans. After the test, the diameter of the inhibition ring was measured. According to the QB / T 2738-2012 standard, if the inhibition ring diameter is greater than 7 mm, the product has an antibacterial effect; if the inhibition ring diameter is less than 7 mm, the product has no antibacterial effect. Meanwhile, an inhibition ring greater than 10 mm and less than 15 mm is considered moderately antibacterial, and an inhibition ring greater than 15 mm is considered highly antibacterial. The data are recorded as shown in Table 1, where - indicates that no inhibition ring was detected.

[0098] 1.2 Antibacterial rate experiment

[0099] With reference to the method in 7.3 of QB / T 2738-2012 "Evaluation Method for Antibacterial and Antimicrobial Effects of Daily Chemical Products", the antibacterial rate test was carried out on the toothpastes obtained in Examples 1-5 and Comparative Examples 1-4, respectively. The action time was 3 minutes, and the antibacterial rate was calculated and recorded as shown in Table 2.

[0100] 1.3 Antibacterial stability test

[0101] With reference to the natural sample retention method in 8.1 of QB / T 2738-2012 "Evaluation Method for Antibacterial and Antimicrobial Effects of Daily Chemical Products", the antibacterial rate of the toothpaste obtained in Example 1 was retested according to the method in 1.2 at 30, 60, and 90 days of sample retention, and the data were recorded as shown in Table 3.

[0102] Table 1 Antibacterial function of different embodiments and comparative examples

[0103]

[0104] Table 2 Antibacterial rates of different embodiments and comparative examples

[0105]

[0106] As can be seen from Table 1, the antibacterial rings of Examples 1-5 for Staphylococcus aureus all reached more than 20.3 mm, the antibacterial rings for Streptococcus mutans reached more than 15.8 mm, the antibacterial rings for Porphyromonas gingivalis reached more than 18.3 mm, and the antibacterial rings for Candida albicans reached more than 14.5 mm, indicating that the Ganpu toothpaste of the present application has an antibacterial effect on various bacterial species, and the antibacterial rings basically reach more than 15 mm, with significant antibacterial effects.

[0107] Among the comparative examples, comparative example 2, which did not add the sugarcane leaf extract and dandelion extract in the herbal composition of the present application, only had a certain antibacterial effect on Streptococcus mutans and Candida albicans; comparative example 3, which did not add the sugarcane leaf extract, and comparative example 4, which did not add the dandelion extract, although had antibacterial effects on various bacterial species, the diameters of the antibacterial rings were not as good as those of Examples 1-5 of the present application.

[0108] As can be seen from Table 2, the antibacterial rates of Examples 1-5 against Staphylococcus aureus all reached more than 99.2%, the antibacterial rates against Streptococcus mutans reached more than 99.1%, the antibacterial rates against Porphyromonas gingivalis reached more than 99.1%, and the antibacterial ring against Candida albicans reached more than 99.3%. Among them, the antibacterial rates of Example 1 against various strains reached 99.8%, 99.9%, 99.6%, and 99.8%, respectively.

[0109] Among the comparative examples, comparative example 2, which did not add the sugarcane leaf extract and dandelion extract in the herbal composition of the present application, comparative example 3, which did not add the sugarcane leaf extract, and comparative example 4, which did not add the dandelion extract, all had lower antibacterial rates against various bacterial species than Examples 1-5 of the present application.

[0110] It is shown that by adding the traditional Chinese medicine composition of the present application, especially the sugarcane leaf extract and the dandelion extract, the antibacterial performance of the toothpaste can be significantly improved, dental diseases caused by bacteria can be reduced, and oral health can be maintained.

[0111] This is because sugarcane leaf extract mainly contains polyphenols, polysaccharides and other substances. Polyphenols can damage bacterial cell membranes through antioxidant effects, causing leakage of intracellular substances and inhibiting bacterial reproduction, while polysaccharide components can bind to bacterial surface receptors, blocking their nutrient absorption or signal transduction, and interfering with bacterial metabolism; dandelion extract mainly contains taraxasterols, taraxacin, chlorogenic acid and other substances. Chlorogenic acid and taraxacin have broad-spectrum inhibitory effects, which can interfere with the activity of bacterial metabolic enzymes, and at the same time can inhibit the formation of oral pathogenic bacteria biofilms and reduce bacterial colonization ability.

[0112] The active ingredients of sugarcane leaf extract and dandelion extract complement each other, which can achieve a broader spectrum of inhibitory effects, thus having good antibacterial properties against a variety of bacterial species. At the same time, polyphenols produce free radicals through oxidation, attacking bacterial cell membranes and causing membrane damage, enabling the active ingredients of dandelion extract to kill bacteria more effectively. The two work together to synergistically improve the antibacterial effect.

[0113] Table 3 Antibacterial stability of Example 1

[0114] strains 30d 60d 90d Golden Gluconobacter (%) 99.6 99.2 98.8 Streptococcus mutans (%) 99.8 99.5 99.1 Porphyromonas gingivalis (%) 98.5 99.3 99 Candida albicans (%) 99.5 99.3 98.2

[0115] As can be seen from Table 3, Example 1 of the present application can still maintain high antibacterial ability after 90 days, has excellent antibacterial stability, and can meet the needs of daily life.

[0116] 2. Anti-inflammatory Experiment

[0117] Sixty male KM mice, weighing 14-16 g, were divided into five experimental groups according to Example 1 and Comparative Examples 1-4, along with a control group of 10 mice per group. The experiment began 3-5 days after the mice were quarantined. The left ear of each group remained untreated, while the right ear was coated with 40 μL of xylene on both sides. After 0.5 hours of inflammation, 0.1 g of the corresponding toothpaste sample was applied to each ear. The control group remained untreated after the right ear was inflamed. One hour later, the mice were sacrificed by cervical dislocation. The samples were cleaned, their ears were cut, and their ears were punched, weighed, and recorded. The swelling value and swelling inhibition rate were calculated and reported as shown in Table 4.

[0118] Swelling value = right ear weight of each mouse - left ear weight;

[0119] Swelling inhibition rate = (swelling value of control group - swelling value of experimental group) / swelling value of control group × 100%.

[0120] Table 4 Toothpaste anti-inflammatory test

[0121] Experimental group Swelling value (mg) Swelling inhibition rate (%) Example 1 7.4 71.2 control group 25.7 / Comparative Example 1 24.2 5.8 Comparative Example 2 18.7 27.2 Comparative Example 3 15.6 39.3 Comparative Example 4 13.4 47.9

[0122] As can be seen from Table 4, the swelling value of mice in Example 1 of the present application was only 7.4 mg, and the swelling inhibition rate reached 71.2%, while the swelling values of Comparative Examples 1-4 were all much greater than that of Example 1. In Comparative Examples 2-4, the swelling values were 18.7 mg, 15.6 mg, and 13.4 mg, respectively, and the swelling inhibition rates were 27.2%, 39.3%, and 47.9%, respectively, all inferior to that of Example 1 of the present application. This shows that the Chinese herbal composition of the present application has excellent anti-inflammatory properties, thereby reducing the inflammatory response of teeth and protecting oral health.

[0123] This is because the polyphenols in sugarcane leaf extract have antioxidant and anti-inflammatory properties, which can reduce the release of inflammatory factors by inhibiting pathways. Dandelion polysaccharides, chlorogenic acid, and sterols can reduce inflammation by regulating inflammatory pathways and inhibiting enzyme activity. Sugarcane inhibits inflammatory signaling pathways, while dandelion inhibits enzyme activity, and both work together to reduce the production of inflammatory mediators. Furthermore, the antioxidants in sugarcane protect the active ingredients in dandelion from oxidative degradation, prolonging their duration of action. Working together, these two ingredients can synergistically reduce the inflammatory response.

[0124] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Ganpu tooth-healthy toothpaste, characterized in that: The invention is prepared from the following raw materials in percentage by weight: 18-26% of abrasive, 0.5-2% of thickener, 35-60% of moisturizer, 1-5% of foaming agent, 3-6% of Chinese herbal medicine composition, 0.1-0.2% of preservative, and the balance is deionized water.

2. The Ganpu toothpaste according to claim 1, characterized in that: The friction agent is one of calcium carbonate, silicon dioxide and calcium phosphate.

3. The Ganpu tooth-healthy toothpaste according to claim 1, characterized in that: The thickener is one of sodium carboxymethyl cellulose, sodium hydroxyethyl cellulose and sodium hydroxypropyl cellulose.

4. The Ganpu toothpaste according to claim 1, characterized in that: The moisturizing agent is glycerin or sorbitol.

5. The Ganpu tooth-healthy toothpaste according to claim 1, characterized in that: The foaming agent is sodium lauryl sulfate or sodium lauryl sulfate.

6. The Ganpu tooth-healthy toothpaste according to claim 1, characterized in that: The preservative is paraben or sodium benzoate.

7. The Ganpu tooth-healthy toothpaste according to claim 1, characterized in that: The traditional Chinese medicine composition is prepared from the following raw materials: sugarcane leaf extract, dandelion extract, murraya oleifera leaf extract, clove flower extract, camellia extract, white ampelopsis extract and mint extract.

8. The Ganpu tooth-healthy toothpaste according to claim 6, characterized in that: In the traditional Chinese medicine composition, sugarcane leaf extract, dandelion extract, Murraya osmanthus leaf extract, clove flower extract, camellia extract, white ampelopsis extract and mint extract are mixed in a mass ratio of 3-8:3-8:2-5:1-2:4-6:1-3:1-2.

9. The Ganpu tooth-healthy toothpaste according to claim 7, characterized in that: In the traditional Chinese medicine composition, sugarcane leaf extract, dandelion extract, Murraya osmanthus leaf extract, clove flower extract, camellia extract, white ampelopsis extract, and mint extract are mixed in a mass ratio of 6:6:3:1:5:3:

1.

10. The method for preparing Ganpu toothpaste according to any one of claims 1 to 9, characterized in that: The following steps are involved: S1: Add moisturizer, preservative and deionized water to the reactor and stir at 600-800 rpm for 10-30 min until completely dissolved; then slowly add the abrasive in 3 portions, with an interval of 2-10 min between each addition, and switch to high shear dispersion at 1200-1500 rpm for 20-60 min, maintaining the system temperature at 50-60°C; S2: Add thickener to the system of S1, stir at 600-1000 rpm for 20-40 min, control the temperature at 50-55°C, and form a uniform colloid; S3: Cool the reaction system of S2 to 45-50°C, add a foaming agent, and stir at 400-600 rpm for 10-30 minutes until dissolved; cool to 40-45°C, add the Chinese herbal extract, switch to a low speed of 200-400 rpm and stir for 10-30 minutes to obtain a paste; S4: Transfer the paste into a high-pressure homogenizer and homogenize it 2-3 times at 30-50°C and a pressure of 15-20 MPa; Then degas for 10-20 minutes at a vacuum degree of -0.09 to -0.1 MPa to obtain the product.

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