Plaster for treating bone fracture and joint diseases and preparation method thereof

Abstract

The invention relates to the field of plasters, in particular to a plaster for treating bone fractures and joint diseases and a preparation method thereof.The plaster for treating bone fractures and joint diseases is formed by sequentially overlapping spunlace non-woven fabric, an ointment layer and release paper from top to bottom; the ointment layer is prepared from the following raw materials: cinnamon, pine nodular branch, sappan wood, sambucus chinensis, teasel root, radix angelicae, rhizoma drynariae, notopterygium root, radix angelicae pubescentis, divaricate saposhnikovia root, angelica sinensis, ligusticum wallichii, pseudo-ginseng, dragon's blood, 40-60 parts of native copper, frankincense, myrrh, eucommia ulmoides, ephedra, radix achyranthis bidentatae, peach kernel, safflower, stiff silkworm, scorpion, centipede, radix clematidis, kochia scoparia, hedyotis diffusa, sambucus williamsii, pimpinella tuberosa, sarcodactylis, piper wallichii, vaccinium bracteatum, zaocys dhumnade and pressure-sensitive adhesive. The plaster for treating bone fracture and joint diseases has the advantages of being good in treatment effect, small in side effect, good in environmental protection property and free of residues.

Description

Technical Field

[0001] The present invention relates to the field of plasters, and in particular to a plaster for treating bone injuries and joint diseases and a preparation method thereof. Background Art

[0002] Bone injuries and joint diseases have a high incidence rate and are difficult to cure, making them a difficult problem that medical scientists from all over the world are currently focusing on. Many people have been living in endless pain all over their bodies for a long time, and have been troubled by the disease and even unable to work. Although most patients do not need hospitalization or surgical treatment, the pain it brings to humans is the most common and widespread, and is a difficult problem for bone injury rehabilitation clinicians. Compared with Western medicine treatment, plaster treatment has the characteristics of being easy to carry and use, and plasters can be directly administered through the skin, which can bypass the first-pass effect of the liver and reduce the burden of drugs on the liver. Plasters can also act directly on the lesion site, have a good effect on local pain, swelling or inflammation, and plasters can slowly release drugs, maintain the efficacy for a long time, and reduce the number of administrations. Therefore, research on plasters has received more and more attention.

[0003] Patent CN103877120B discloses a plaster, which is made of 8-10 parts of iodine tincture, 30-60 parts of white vaseline, 25-55 parts of borneol, and 5-7 parts of iodine tincture by weight. Its preparation method includes three steps: mixing, heating, and cooling stages. The plaster of this invention has good efficacy and significant therapeutic effect for chronic strain diseases such as traumatic injuries, low back pain, cervical spondylosis, and frozen shoulder; good medicinal properties, no gastrointestinal adverse reactions and side effects, easy for patients to accept, fast transdermal onset, and good patient compliance. However, the active ingredients of this plaster only contain iodine tincture, borneol, and iodine tincture, which play a role in sterilization and analgesia, and are less effective in treating joint diseases.

[0004] Patent CN106822272C provides a kind of external-use plaster for the diseases such as intervertebral disc herniation, bone hyperplasia, rheumatism and rheumatoid arthritis, its raw material comprises Herba Scutellariae Sinensis, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Radix Angelicae Pubescentis, Flos Carthami, Radix Notoginseng, Rhizoma Chuanxiong, Olibanum, Myrrha, Scorpio, Radix Aconiti Lateralis Preparata, Radix Notopterygii, Radix Achyranthis Bidentatae, Radix Clematidis, and plaster base, sesame oil are appropriate, medicinal material is soaked in sesame oil, fried and takes medicinal oil, oil refining, adds plaster base, leaves and removes fire poison, spreads and applies into plaster and obtains finished product. The plaster that this invention prepares takes effect rapidly, sticks on the same day and can be effective, and is remarkable in efficacy, can quickly soothe muscle, improve joint, relieve pain, without any toxic and side effects, safe and reliable. But the preparation technology of anesthetic plaster is comparatively complicated, needs accurate control, and technical requirements are high, and in the process of oil refining and lower dan, a large amount of oil smoke and irritating black smoke can be produced, pollutes the environment, and also threatens the health of operator simultaneously.

[0005] Therefore, the market is in urgent need of a plaster for treating bone injuries and joint diseases with good therapeutic effect, good environmental protection and simple preparation process. Summary of the Invention

[0006] In view of the problems existing in the prior art, the purpose of the present invention is to obtain a plaster for treating bone injuries and joint diseases which has good therapeutic effect, good environmental protection, is not easy to leave residue on the skin and has a simple preparation process.

[0007] In order to achieve the above object, the technical solution adopted by the present invention is as follows:

[0008] On one hand, the present invention provides a plaster for treating bone injuries and joint diseases, which is formed by stacking a spunlace non-woven fabric, an ointment layer, and a release paper in sequence from top to bottom; the ointment layer is prepared by including the following raw materials, by weight: 20-40 parts of cinnamon bark, 40-60 parts of Chinese pine knot, 40-60 parts of sappan wood, 50-70 parts of comfrey, 40-60 parts of knotweed, 40-60 parts of angelica dahurica, 40-60 parts of drynaria, 20-40 parts of notopterygium root, 20-40 parts of angelica pubescens, 20-40 parts of siler, 20-40 parts of ligusticum wallichii, 40-60 parts of sanqi, 40-60 parts of dragon's blood, and 20-40 parts of angelica sinensis. 40-60 parts of copper phosphate, 40-60 parts of frankincense, 40-60 parts of myrrh, 20-40 parts of eucommia bark, 15-25 parts of ephedra, 15-25 parts of cyathula, 20-40 parts of peach kernel, 20-40 parts of safflower, 20-40 parts of bombyx batryticatus, 20-40 parts of scorpio, 30-40 parts of centipedes, 20-40 parts of clematis root, 20-40 parts of kochia bark, 40-60 parts of snow glomerate, 40-60 parts of elderberry, 40-60 parts of monkey tuckahoe, 40-60 parts of bone-changing tendon, 40-60 parts of eucommia bark, 40-60 parts of black rice tree, 40-60 parts of garcinia, and 350-450 parts of pressure-sensitive adhesive.

[0009] The present application prepares a medicinal powder by selecting various Chinese medicines with good compatibility, then blends the powder with a hot-melt pressure-sensitive adhesive to prepare an ointment, and then spreads the ointment on a spunlace non-woven fabric to form an ointment layer. After cooling to room temperature, the ointment layer is covered with release paper. The obtained ointment has the characteristics of good therapeutic effect, good environmental protection, not easy to leave residue on the skin, and simple preparation process.

[0010] In some embodiments, the preparation method of the pressure-sensitive adhesive comprises the following steps: 50-55 parts of natural rubber, by weight, are plasticized on an open mill at a plasticizing temperature of 40-50°C, a plasticizing time of 15-30 minutes, and a roller spacing of 0.5-1 mm; 8-12 parts of modified rosin resin, 1-2 parts of terpene resin, 0.3-0.6 parts of vulcanizing agent, and 5-10 parts of filler are added and mixed for 20-30 minutes to obtain the pressure-sensitive adhesive.

[0011] Preferably, the vulcanizing agent is sulfur.

[0012] In some embodiments, the preparation method of the modified rosin resin comprises the following steps: adding rosin resin to a reaction vessel, heating to 180-190° C. and stirring for 5-10 minutes, adding a catalyst, lignin and glycerol, heating to 250-260° C. and reacting for 5-7 hours, cooling to 170-180° C., adding azobisisobutyronitrile and N-vinylcaprolactam and reacting for 1-2 hours to obtain the modified rosin resin.

[0013] Preferably, the catalyst is a composition of zinc oxide and magnesium oxide, and the mass ratio of the two is 1:(0.5-1).

[0014] Preferably, the mass ratio of the rosin resin to glycerin is 1:(0.05-0.15).

[0015] Rosin resin is often used as a tackifier for natural rubber, but rosin resin has a high acid value and is easily oxidized, which limits its application and processing. In response to the above problems, the present application uses lignin containing hydroxyl, methoxy, and benzene ring structures as a modifier to undergo an esterification reaction with the rosin resin to reduce its acid value. The applicant has also found that adding modified rosin resin to a plaster system can prolong the use effect of the plaster. This may be because lignin contains a large amount of phenols that can capture free radicals, and a large amount of benzene rings and double bond structures can absorb ultraviolet rays. Therefore, the rosin resin introduced with lignin chain segments has good antioxidant properties and is thus conducive to improving the efficacy of the drug. The present application further reacts the rosin resin with N-vinylcaprolactam to form an azone structure on the rosin resin, which can improve the permeability of the drug on the skin and thus improve the therapeutic effect of the plaster.

[0016] In some embodiments, the mass ratio of the rosin resin to the lignin is 1:(0.05-0.1).

[0017] Lignin has a low softening point and may lower the softening point of rosin resin after reacting with rosin resin, thereby affecting the bonding strength of the pressure-sensitive adhesive. This application limits the ratio of rosin resin to lignin, which can improve the therapeutic effect of the plaster while improving the viscosity of the pressure-sensitive adhesive, making the ointment easy to tear off with the non-woven fabric and not easy to remain on the skin.

[0018] In some embodiments, the mass ratio of the rosin resin to N-vinyl caprolactam is 1:(0.02-0.05).

[0019] In some embodiments, the filler is modified zinc oxide.

[0020] In some embodiments, the method for preparing the modified zinc oxide comprises the following steps: adding zinc oxide and KH570 silane coupling agent to 85-95 wt% ethanol aqueous solution, reacting at 50-60° C. for 5-6 hours, filtering, and drying to obtain modified zinc oxide.

[0021] In some embodiments, the mass ratio of zinc oxide to silane coupling agent is 1:(0.02-0.06).

[0022] The present application improves the compatibility of zinc oxide with natural rubber by modifying zinc oxide with KH570 silane coupling agent, and introduces double bond groups on zinc oxide so that multiple double bonds on the modified zinc oxide can participate in the reaction during the rubber vulcanization process, so that the zinc oxide can be evenly distributed in the ointment, thereby achieving good bactericidal and antioxidant effects, which is beneficial to improving the therapeutic effect of the ointment. In addition, zinc oxide can serve as a vulcanization accelerator for natural rubber to promote the vulcanization of rubber, which is beneficial to improving the viscosity of the pressure-sensitive adhesive and making it less likely for the ointment to remain on the skin.

[0023] Another aspect of the present invention provides a method for preparing a plaster for treating bone injuries and joint diseases, comprising the following steps:

[0024] S1. Cinnamon bark, Chinese pine knot, sappan wood, comfrey, dipsaccharum officinale, angelica dahurica, drynaria root, notopterygium root, angelica pubescens, saposhnikovia root, angelica sinensis, ligusticum chuanxiong, Panax notoginseng, dragon's blood, natural copper, frankincense, myrrh, eucommia bark, ephedra, cyathula, peach kernel, safflower, bombyx batryticatus, scorpion, centipede, clematis root, kochia bark, snow red, elderberry, monkey tau root, bone-changing tendon, heather vine, blueberry tree, and snakehead snake are crushed and sieved, mixed and stirred at room temperature for 20-30 minutes to obtain a powder;

[0025] S2, heating the pressure-sensitive adhesive to 150-160° C. to obtain an adhesive solution;

[0026] S3, adding the powder obtained in step S1 to the glue obtained in step S2, stirring at 140-150° C. for 1-2 hours, and keeping warm to obtain an ointment;

[0027] S4. Spread the ointment obtained in step S3 on the spunlace non-woven fabric to form an ointment layer, cool it to room temperature, cover the ointment layer with release paper, roll it up, and slice it to obtain a plaster.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] (1) The present invention prepares a medicinal powder by selecting various Chinese medicines with good compatibility, and then blends it with a hot-melt pressure-sensitive adhesive to prepare an ointment. The ointment is then spread on a spunlace non-woven fabric to form an ointment layer. The ointment layer is cooled to room temperature and covered with a release paper. The obtained ointment has the characteristics of good therapeutic effect, good environmental protection, not easy to remain on the skin, and a simple preparation process.

[0030] (2) The present invention uses lignin containing hydroxyl, methoxy, and benzene ring structures as a modifier to undergo an esterification reaction with rosin resin to reduce its acid value. Furthermore, the present invention can improve the antioxidant properties of rosin resin by introducing lignin chain segments into rosin resin, thereby prolonging the use effect of the plaster. Furthermore, the present invention further reacts rosin resin with N-vinylcaprolactam to form an azone structure on the rosin resin, thereby improving the permeability of the drug on the skin and thereby enhancing the therapeutic effect of the plaster.

[0031] (3) The present invention can improve the compatibility of zinc oxide with natural rubber by using KH570 silane coupling agent to modify zinc oxide, and introduce double bond groups on zinc oxide so that multiple double bonds on the modified zinc oxide can participate in the reaction during the rubber vulcanization process, so that zinc oxide can be evenly distributed in the ointment, playing a good bactericidal effect and antioxidant effect, which is beneficial to improving the therapeutic effect of the ointment, and zinc oxide can be used as a vulcanization accelerator of natural rubber to promote the vulcanization of rubber, which is beneficial to improving the viscosity between the pressure-sensitive adhesive and the powder so that the ointment is not easy to remain on the skin. DETAILED DESCRIPTION

[0032] The present invention will be described below in conjunction with specific embodiments. It should be noted that the following examples are illustrative of the present invention and are intended only to illustrate the present invention and are not intended to limit the present invention. Other combinations and various modifications within the scope of the present invention may be made without departing from the spirit or scope of the present invention.

[0033] In the following examples and comparative examples, except for modified zinc oxide and modified rosin resin, the other compounds and related reagents used can be purchased from the market. Among them, natural rubber was purchased from Jining Tangyi Chemical Co., Ltd.; rosin resin was purchased from Jinan Yongyue Chemical Co., Ltd.; terpene resin model T100 was purchased from Shandong Xinghai Chemical Co., Ltd.; zinc oxide with an average particle size of 50 nm was purchased from Fujian Ruisen New Materials Co., Ltd.

[0034] Preparation Example 1

[0035] The preparation method of modified rosin resin-1 comprises the following steps: adding 10 g of rosin resin into a reaction vessel, heating to 185° C. and stirring for 7 minutes, adding 1 g of zinc oxide, 0.7 g of magnesium oxide, 0.7 g of lignin, and 1 g of glycerol, heating to 255° C. and reacting for 6 hours, cooling to 175° C., adding 0.01 g of azobisisobutyronitrile and 0.35 g of N-vinylcaprolactam, and reacting for 1.5 hours to obtain modified rosin resin-1.

[0036] Preparation Example 2

[0037] The preparation method of modified rosin resin-2 is the same as that of Preparation Example 1, except that the amount of lignin added is 1.2 g.

[0038] Preparation Example 3

[0039] The preparation method of modified rosin resin-3 is the same as that of Preparation Example 1, except that the added amount of N-vinylcaprolactam is 0.1 g.

[0040] Preparation Example 4

[0041] The preparation method of modified zinc oxide-1 comprises the following steps: adding 10g zinc oxide and 0.4g KH570 silane coupling agent to 50g 90wt% ethanol aqueous solution, reacting at 55°C for 5h, filtering and drying to obtain modified zinc oxide-1.

[0042] Preparation Example 5

[0043] The preparation method of modified zinc oxide-2 is the same as that of Preparation Example 4, except that the added amount of KH570 silane coupling agent is 0.1 g.

[0044] Preparation Example 6

[0045] The preparation method of pressure-sensitive adhesive-1 comprises the following steps: 52 parts of natural rubber, by weight, are plasticized on an open mill at a plasticizing temperature of 45°C, a plasticizing time of 20 minutes, and a roller distance of 0.7 mm; 10 parts of modified rosin resin-1, 1.5 parts of terpene resin, 0.45 parts of sulfur, and 7.5 parts of modified zinc oxide are added and mixed for 25 minutes to obtain the pressure-sensitive adhesive.

[0046] Preparation Example 7

[0047] The preparation method of pressure-sensitive adhesive-2 is the same as that of Preparation Example 6, except that an equal amount of modified rosin resin-1 is replaced by modified rosin resin-2.

[0048] Preparation Example 8

[0049] The preparation method of pressure-sensitive adhesive-3 is the same as that of Preparation Example 6, except that an equal amount of modified rosin resin-1 is replaced by modified rosin resin-3.

[0050] Preparation Example 9

[0051] The preparation method of pressure-sensitive adhesive-4 is the same as that of Preparation Example 6, except that an equal amount of modified zinc oxide-1 is replaced by modified zinc oxide-2.

[0052] Preparation Example 10

[0053] The preparation method of pressure-sensitive adhesive-5 is the same as that of Preparation Example 6, except that an equal amount of modified zinc oxide-1 is replaced by zinc oxide.

[0054] Preparation Example 11

[0055] The preparation method of pressure-sensitive adhesive-6 is the same as that of Preparation Example 6, except that an equal amount of modified rosin resin-1 is replaced by rosin resin.

[0056] Example 1

[0057] A plaster for treating bone injuries and joint diseases, which is formed by laminating a spunlace non-woven fabric, an ointment layer, and a release paper in order from top to bottom; the ointment layer is prepared by the following raw materials, in parts by weight: 30 parts of cinnamon bark, 50 parts of Chinese pine knot, 50 parts of sappan wood, 60 parts of comfrey, 50 parts of knotweed, 50 parts of angelica dahurica, 50 parts of drynaria, 30 parts of notopterygium wilfordii, 30 parts of angelica pubescens, 30 parts of siler, 30 parts of radix scutellariae, 30 parts of angelica sinensis, 30 parts of ligusticum chuanxiong, 50 parts of sanqi, 30 parts of blood 50 parts of dried herbs, 50 parts of natural copper, 50 parts of frankincense, 50 parts of myrrh, 30 parts of Eucommia ulmoides, 20 parts of ephedra, 20 parts of Achyranthes bidentata, 30 parts of peach kernel, 30 parts of safflower, 30 parts of bombyx batryticatus, 30 parts of scorpio, 35 parts of centipedes, 30 parts of clematis root, 30 parts of Kochia scoparia, 50 parts of snow red, 50 parts of elder, 50 parts of monkey tau root, 50 parts of bone-changing tendon, 50 parts of succulent vine, 50 parts of blueberry tree, 50 parts of garcinia cerasifera, 50 parts of jasmine flower, and 1400 parts of pressure-sensitive adhesive.

[0058] The preparation method of the plaster for treating bone injuries and joint diseases in this embodiment comprises the following steps:

[0059] S1. Cinnamon bark, pine knot, sappan wood, comfrey, dipsaccharum officinale, angelica dahurica, drynaria root, notopterygium wilfordii, angelica pubescens, ligusticum salsa, siler, angelica sinensis, ligusticum chuanxiong, Panax notoginseng, dragon's blood, natural copper, frankincense, myrrh, eucommia bark, ephedra, cyathula, peach kernel, safflower, bombyx batryticatus, scorpion, centipede, clematis root, kochia scoparia, snow red, elderberry, monkey tau vine, bone-changing tendon, heather vine, blueberry tree, and snakehead snake were crushed and passed through an 80-mesh sieve, mixed and stirred at room temperature for 25 minutes to obtain a powder;

[0060] S2, heating the pressure-sensitive adhesive-1 to 155° C. to obtain an adhesive solution;

[0061] S3, adding the powder obtained in step S1 to the glue obtained in step S2, stirring at 145° C. for 1.5 h, and keeping warm to obtain an ointment;

[0062] S4. Spread the ointment obtained in step S3 on the spunlace non-woven fabric to form an ointment layer with a thickness of 0.2 mm. Cool it to room temperature, cover the ointment layer with release paper, roll it up, and slice it to obtain a plaster.

[0063] Example 2

[0064] A plaster for treating bone injuries and joint diseases, which is formed by stacking a spunlace non-woven fabric, an ointment layer, and a release paper in order from top to bottom; the ointment layer comprises the following raw materials, by weight: 20 parts of cinnamon bark, 40 parts of Chinese pine knot, 40 parts of sappan wood, 50 parts of comfrey, 40 parts of dipsaccharin, 40 parts of angelica dahurica, 40 parts of drynaria, 20 parts of notopterygium wilfordii, 20 parts of angelica pubescens, 20 parts of siler, 20 parts of radix siler, 20 parts of angelica sinensis, 20 parts of ligusticum chuanxiong, and 40 parts of notoginseng , 40 parts of dragon's blood, 40 parts of natural copper, 40 parts of frankincense, 40 parts of myrrh, 20 parts of eucommia, 15 parts of ephedra, 15 parts of achyranthes, 20 parts of peach kernel, 20 parts of safflower, 20 parts of bombyx batryticatus, 20 parts of scorpion, 30 parts of centipede, 20 parts of clematis, 20 parts of kochia bark, 40 parts of snow red, 40 parts of elder, 40 parts of monkey tau, 40 parts of bone-changing tendon, 40 parts of heather vine, 40 parts of blueberry tree, 40 parts of garcinia, 40 parts of jasmine, pressure-sensitive adhesive -1 350 parts.

[0065] The preparation method of the plaster for treating bone injuries and joint diseases in this embodiment comprises the following steps:

[0066] S1. Cinnamon bark, pine knot, sappan wood, comfrey, dipsaccharum officinale, angelica dahurica, drynaria root, notopterygium wilfordii, angelica pubescens, ligusticum salsa, siler, angelica sinensis, ligusticum chuanxiong, Panax notoginseng, dragon's blood, natural copper, frankincense, myrrh, eucommia bark, ephedra, cyathula, peach kernel, safflower, bombyx batryticatus, scorpion, centipede, clematis root, kochia scoparia, snow red, elderberry, monkey tau vine, bone-changing tendon, heather vine, blueberry tree, and snakehead snake were crushed and passed through an 80-mesh sieve, mixed and stirred at room temperature for 20 minutes to obtain a powder;

[0067] S2, heating the pressure-sensitive adhesive-1 to 150° C. to obtain an adhesive solution;

[0068] S3, adding the powder obtained in step S1 to the glue obtained in step S2, stirring at 140° C. for 2 h, and keeping warm to obtain an ointment;

[0069] S4. Spread the ointment obtained in step S3 on the spunlace non-woven fabric to form an ointment layer with a thickness of 0.1 mm. Cool it to room temperature, cover the ointment layer with release paper, roll it up, and slice it to obtain a plaster.

[0070] Example 3

[0071] A plaster for treating bone injuries and joint diseases, which is formed by stacking a spunlace non-woven fabric, an ointment layer, and a release paper in order from top to bottom; the ointment layer includes the following raw materials, by weight: 40 parts of cinnamon bark, 60 parts of Chinese pine knots, 60 parts of sappan wood, 70 parts of comfrey, 60 parts of knotweed, 60 parts of angelica dahurica, 60 parts of drynaria, 40 parts of notopterygium wilfordii, 40 parts of angelica pubescens, 40 parts of siler, 40 parts of radix siler, 40 parts of angelica sinensis, 40 parts of ligusticum chuanxiong, and 60 parts of sanchi. , 60 parts of dragon's blood, 60 parts of natural copper, 60 parts of frankincense, 60 parts of myrrh, 40 parts of eucommia, 25 parts of ephedra, 25 parts of cyathula, 40 parts of peach kernel, 40 parts of safflower, 40 parts of bombyx batryticatus, 40 parts of scorpion, 40 parts of centipede, 40 parts of clematis, 40 parts of kochia bark, 60 parts of snow red, 60 parts of elder, 60 parts of monkey tau, 60 parts of bone-changing tendon, 60 parts of cyathula, 60 parts of black rice tree, 60 parts of garcinia, and 450 parts of pressure-sensitive adhesive -1.

[0072] The preparation method of the plaster for treating bone injuries and joint diseases in this embodiment comprises the following steps:

[0073] S1. Cinnamon bark, pine knot, sappan wood, comfrey, dipsaccharum officinale, angelica dahurica, drynaria root, notopterygium root, angelica pubescens, siler, radix scutellariae, angelica sinensis, ligusticum chuanxiong, sanqi, dragon's blood, natural copper, frankincense, myrrh, eucommia bark, ephedra, cyathula, peach kernel, safflower, bombyx batryticatus, scorpion, centipede, clematis root, kochia bark, snow red, elderberry, monkey tau root, bone-changing tendon, heather vine, blueberry tree, and snakehead snake were crushed and passed through an 80-mesh sieve, mixed and stirred at room temperature for 30 minutes to obtain a powder;

[0074] S2, heating the pressure-sensitive adhesive-1 to 150° C. to obtain an adhesive solution;

[0075] S3, adding the powder obtained in step S1 to the glue obtained in step S2, stirring at 150° C. for 2 h, and keeping warm to obtain an ointment;

[0076] S4. Spread the ointment obtained in step S3 on the spunlace non-woven fabric to form an ointment layer with a thickness of 0.3 mm. Cool it to room temperature, cover the ointment layer with release paper, roll it up, and slice it to obtain a plaster.

[0077] Example 4

[0078] A plaster for treating bone injuries and joint diseases and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that an equal amount of pressure-sensitive adhesive-1 is replaced by pressure-sensitive adhesive-2.

[0079] Example 5

[0080] A plaster for treating bone injuries and joint diseases and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that an equal amount of pressure-sensitive adhesive-1 is replaced by pressure-sensitive adhesive-3.

[0081] Example 6

[0082] A plaster for treating bone injuries and joint diseases and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that an equal amount of pressure-sensitive adhesive-1 is replaced by pressure-sensitive adhesive-4.

[0083] Example 7

[0084] A plaster for treating bone injuries and joint diseases and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that an equal amount of pressure-sensitive adhesive-1 is replaced by pressure-sensitive adhesive-5.

[0085] Example 8

[0086] A plaster for treating bone injuries and joint diseases and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that an equal amount of pressure-sensitive adhesive-1 is replaced by pressure-sensitive adhesive-6.

[0087] Performance Testing

[0088] The performance tests of the plasters for treating bone injuries and joint diseases obtained in the above embodiments were carried out:

[0089] In this clinical trial, 80 patients with lumbar disc herniation, bone hyperplasia, rheumatism and similar diseases were selected and agreed to use the plasters prepared in the above examples for clinical research treatment. Each group had 10 volunteers. The above plaster was applied to the test patients for clinical treatment and observation, with one application per day. After 5 applications, the treatment effect was recorded and the presence of plaster residue on the patient's skin was observed: clinical symptoms disappeared and normal work was resumed, which was considered cured; clinical symptoms basically disappeared, normal activities were not significantly restricted, and normal work could be resumed, which was considered markedly effective; clinical symptoms were significantly improved, symptoms may appear after excessive activity, but they were alleviated compared to before, and the patient could participate in lighter work, which was considered effective; none of the above conditions were considered ineffective.

[0090] The test results are shown in Table 1:

[0091] Table 1

[0092] Group get well Significantly effective efficient invalid Is there any plaster residue? Example 1 7 2 1 0 none Example 2 6 3 1 0 none Example 3 6 2 2 0 none Example 4 6 2 2 0 have Example 5 5 2 2 1 none Example 6 5 2 3 0 none Example 7 5 1 4 0 none Example 8 4 3 2 1 none

[0093] As can be seen from the data in Table 1, the plasters for treating bone injuries and joint diseases in Examples 1-3 of the present invention have good therapeutic effects. From the comparison of Example 4 and Example 1, it can be seen that changing the ratio of rosin resin and lignin can lower the softening point of rosin resin and affect the bonding strength of the pressure-sensitive adhesive, thereby causing residual glue in the plaster; from the comparison of Example 5 and Example 1, it can be seen that changing the ratio of rosin resin and N-vinyl caprolactam can make it difficult to form an azone structure with a penetration-promoting effect on the rosin resin, thereby worsening the therapeutic effect of the plaster; from the comparison of Example 6 and Example 1, it can be seen that changing the ratio of zinc oxide and silane coupling agent plaster can make zinc oxide difficult to disperse, thereby worsening the therapeutic effect of the plaster; from the comparison of Example 7 and Example 1, it can be seen that the therapeutic effect of the plaster directly adding zinc oxide decreases; from the comparison of Example 8 and Example 1, it can be seen that the therapeutic effect of the plaster is poor when rosin resin is directly added.

[0094] The above embodiments are only for illustrating the technical concept and features of the present invention. Its purpose is to enable people familiar with this technology to understand the content of the present invention and implement it. It cannot be used to limit the scope of protection of the present invention. Any equivalent changes or modifications made according to the spirit of the present invention should be included in the scope of protection of the present invention.

Claims

1. A plaster for treating bone injuries and joint diseases, characterized in that: The ointment layer is prepared by stacking a spunlace non-woven fabric, an ointment layer, and a release paper in sequence from top to bottom; the ointment layer comprises the following raw materials, by weight: 20-40 parts of cinnamon bark, 40-60 parts of Chinese pine knot, 40-60 parts of sappan wood, 50-70 parts of comfrey, 40-60 parts of knotweed, 40-60 parts of angelica dahurica, 40-60 parts of drynaria, 20-40 parts of notopterygium root, 20-40 parts of angelica root, 20-40 parts of siler, 20-40 parts of ligusticum, 20-40 parts of chuanxiong, 40-60 parts of sanqi, 40-60 parts of dragon's blood, 40-60 parts of natural copper, 40-60 parts of frankincense. 0-60 parts, myrrh 40-60 parts, eucommia ulmoides 20-40 parts, ephedra 15-25 parts, achyranthes bidentata 15-25 parts, peach kernel 20-40 parts, safflower 20-40 parts, bombyx batryticatus 20-40 parts, scorpio 20-40 parts, centipede 30-40 parts, clematis root 20-40 parts, kochia bark 20-40 parts, snow red 40-60 parts, elder 40-60 parts, monkey tau vine 40-60 parts, bone-changing tendon 40-60 parts, cyperus ternata 40-60 parts, black rice tree 40-60 parts, garter snake 40-60 parts, pressure-sensitive adhesive 350-450 parts.

2. The plaster for treating bone injuries and joint diseases according to claim 1, characterized in that The preparation method of the pressure-sensitive adhesive comprises the following steps: plasticizing 50-55 parts of natural rubber by weight on an open mill at a plasticizing temperature of 40-50° C., a plasticizing time of 15-30 minutes, and a roller distance of 0.5-1 mm; adding 8-12 parts of modified rosin resin, 1-2 parts of terpene resin, 0.3-0.6 parts of vulcanizing agent, and 5-10 parts of filler, and mixing for 20-30 minutes to obtain the pressure-sensitive adhesive.

3. The plaster for treating bone injuries and joint diseases according to claim 1, characterized in that The preparation method of the modified rosin resin comprises the following steps: adding rosin resin into a reaction vessel, heating to 180-190° C. and stirring for 5-10 minutes, adding a catalyst, lignin and glycerin, heating to 250-260° C. and reacting for 5-7 hours, cooling to 170-180° C., adding azobisisobutyronitrile and N-vinylcaprolactam and reacting for 1-2 hours to obtain the modified rosin resin.

4. The plaster for treating bone injuries and joint diseases according to claim 3, characterized in that The mass ratio of the rosin resin to the lignin is 1:(0.05-0.1).

5. The plaster for treating bone injuries and joint diseases according to claim 3, characterized in that: The mass ratio of the rosin resin to N-vinyl caprolactam is 1:(0.02-0.05).

6. The plaster for treating bone injuries and joint diseases according to claim 1, characterized in that: The filler is modified zinc oxide.

7. The method for preparing the plaster for treating bone injuries and joint diseases according to claim 6, characterized in that: The preparation method of the modified zinc oxide comprises the following steps: adding zinc oxide and KH570 silane coupling agent into 85-95 wt% ethanol aqueous solution, reacting at 50-60° C. for 5-6 hours, filtering, and drying to obtain the modified zinc oxide.

8. The plaster for treating bone injuries and joint diseases according to claim 7, characterized in that: The mass ratio of the zinc oxide to the KH570 silane coupling agent is 1:(0.02-0.06).

9. A method for preparing the plaster for treating bone injuries and joint diseases according to any one of claims 1 to 8, characterized in that: The following steps are involved: S1. Cinnamon bark, Chinese pine knot, sappan wood, comfrey, dipsaccharum officinale, angelica dahurica, drynaria root, notopterygium root, angelica pubescens, saposhnikovia root, angelica sinensis, ligusticum chuanxiong, Panax notoginseng, dragon's blood, natural copper, frankincense, myrrh, eucommia bark, ephedra, cyathula, peach kernel, safflower, bombyx batryticatus, scorpion, centipede, clematis root, kochia bark, snow red, elderberry, monkey tau root, bone-changing tendon, heather vine, blueberry tree, and snakehead snake are crushed and sieved, mixed and stirred at room temperature for 20-30 minutes to obtain a powder; S2, heating the pressure-sensitive adhesive to 150-160° C. to obtain an adhesive solution; S3, adding the powder obtained in step S1 to the glue obtained in step S2, stirring at 140-150° C. for 1-2 hours, and keeping warm to obtain an ointment; S4. Spread the ointment obtained in step S3 on the spunlace non-woven fabric to form an ointment layer, cool it to room temperature, cover the ointment layer with release paper, roll it up, and slice it to obtain a plaster.

10. The method for preparing the plaster for treating bone injuries and joint diseases according to claim 9, characterized in that: The thickness of the ointment layer is 0.1-0.3 mm.