Traditional Chinese medicine composition for improving symptoms of liver stagnation transforming into fire disturbing heart and preparation method and application thereof

Abstract

This invention belongs to the field of traditional Chinese medicine, specifically relating to a traditional Chinese medicine composition for clearing heat and relieving irritability, its preparation method, and its application. The traditional Chinese medicine composition of this invention, by weight, comprises the following raw materials: 5-30 parts Asparagus root, 2-15 parts Chrysanthemum, 5-10 parts Imperata root, 2-5 parts Rose, 3-10 parts Lophatherum leaf, and 3-6 parts Tangerine peel. This traditional Chinese medicine composition for clearing heat and relieving irritability has the effects of clearing and moistening heart fire, relieving depression and irritability, calming the mind and aiding sleep. Clinical studies have shown that this traditional Chinese medicine composition for clearing heat and relieving irritability can effectively improve symptoms such as insomnia, excessive dreaming, palpitations, irritability, dry mouth, bitter taste, oral ulcers, and hypochondriac distension caused by liver qi stagnation and its transformation into fire disturbing the heart.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine, specifically relating to a traditional Chinese medicine composition for improving symptoms of liver stagnation and fire disturbing the heart, its preparation method, and its application. Background Technology

[0002] With changes in lifestyle and pace of life in today's society, the incidence of various mental illnesses has increased by 30% to 50% compared to 20 years ago. Currently, a series of problems affecting physical and mental health, such as irritability, palpitations, sleep disorders, dry mouth, bitter taste, oral ulcers, and hypochondriac distension, which are secondary to mood disorders, are receiving increasing attention. For these symptoms, traditional Chinese medicine mainly focuses on calming the mind and promoting sleep, while Western medicine primarily uses sleep aids. However, traditional calming and sleep aids are mostly cold in nature, easily depleting the spleen and stomach's yang energy, leading to adverse reactions such as fatigue, loss of appetite, etc., and symptoms tend to recur after discontinuation. Currently, the effects of commercially available traditional Chinese medicine combinations for these symptoms are unsatisfactory, with symptoms not significantly improved after use. Therefore, it is necessary to develop a traditional Chinese medicine combination that can effectively improve these symptoms. Summary of the Invention

[0003] The first objective of this invention is to provide a traditional Chinese medicine composition for improving symptoms of liver stagnation and fire disturbing the heart. The second objective of this invention is to provide a method for preparing the traditional Chinese medicine composition. The third objective of this invention is to provide the application of the traditional Chinese medicine composition.

[0004] According to a first aspect of the present invention, a traditional Chinese medicine composition for improving symptoms of liver stagnation and fire disturbing the heart is provided, wherein the raw materials comprising, by weight, are: 5-30 parts of Asparagus cochinchinensis, 2-15 parts of Chrysanthemum morifolium, 5-10 parts of Imperata cylindrica root, 2-5 parts of Rose mori, 3-10 parts of Lophatherum gracile, and 3-6 parts of Citrus reticulata peel.

[0005] This invention posits that emotional distress caused by work or study pressure can lead to stagnation of liver qi. This stagnation, when it transforms into fire, easily disturbs the mind, causing symptoms such as irritability, palpitations, sleep disturbances, dry mouth, bitter taste, oral ulcers, and distension in the hypochondrium. Clearing and moistening heart fire, relieving stagnation and alleviating irritability are the main methods for treating these symptoms. This invention uses clearing and moistening heart fire and soothing the liver to relieve stagnation as its treatment principles.

[0006] In this formula, Asparagus cochinchinensis and Chrysanthemum morifolium are the principal herbs. Asparagus cochinchinensis nourishes Yin and moistens dryness, and enters the lung and kidney meridians. Chrysanthemum morifolium calms the liver and clears heat, and also enters the lung and liver meridians. The *Bielu* records that it can "remove chest heat and irritability." Together, they nourish kidney Yin to reduce heart fire and clear liver heat to calm liver fire, achieving the combined effects of nourishing Yin, reducing fire, purging heat, and relieving irritability. Imperata cylindrica root and Lophatherum gracile are the assistant herbs. Imperata cylindrica root clears heat and promotes urination, while Lophatherum gracile enters the heart meridian. The *Compendium of Materia Medica* states that it can "remove irritability and heat, promote urination, and clear the heart," thus having the effects of clearing heat, purging fire, and promoting urination. When used together, these herbs guide the heart fire downwards, enhancing their effect of clearing heat and purging fire. Rose is the guiding herb; according to *Ben Cao Zai Xin*, it can "soothe the stagnation of liver and gallbladder qi, strengthen the spleen and reduce fire," thus both regulating qi and relieving stagnation to soothe liver qi, and guiding the medicine to the liver to clear liver fire. Tangerine peel is the adjuvant herb; according to *Ben Cao Fen Jing*, "Guangdong tangerine peel is pungent, bitter, and warm... it benefits qi, regulates the middle jiao, eliminates phlegm, relieves chest congestion, promotes the flow of qi in the five internal organs, and treats all diseases," thus strengthening the spleen and regulating qi. While regulating qi and relieving stagnation, it also prevents the above herbs from being too cold and damaging the spleen and stomach yang qi. The entire formula works together to clear and moisten heart fire, regulate qi and relieve stagnation, effectively improving symptoms such as insomnia, excessive dreaming, palpitations, irritability, dry mouth, bitter taste, oral ulcers, and distension in the hypochondrium caused by liver qi stagnation and its transformation into fire disturbing the heart.

[0007] The raw materials for this formula come from the following sources:

[0008] Asparagus: The dried tuberous root of Asparagus cochinchinensis (Lour.) Merr., a plant of the Liliaceae family.

[0009] Chrysanthemum: The dried capitulum of Chrysanthemum morifolium Ramat., a plant in the genus Chrysanthemum of the family Asteraceae.

[0010] Imperata cylindrica root: The rhizome of Imperata cylindrica Beauv. var. major (Nees) CE Hubb., a plant belonging to the genus Imperata of the Poaceae family.

[0011] Rose: The dried flower bud of Rosa rugosa Thunb., a plant belonging to the genus Rosa in the family Rosaceae.

[0012] Lophatherum gracile Brongn.: The dried stems and leaves of Lophatherum gracile Brongn., a plant belonging to the genus Lophatherum in the family Poaceae.

[0013] Dried tangerine peel: The dried, mature peel of Citrus reticulata Blanco and its cultivated varieties, belonging to the Rutaceae family and the Citrus genus.

[0014] In some embodiments, the dosage form of the traditional Chinese medicine composition for improving symptoms of liver stagnation and fire disturbing the heart is an oral solution, powder, or granule.

[0015] In some implementations, pharmaceutically acceptable excipients may also be added.

[0016] In some embodiments, the excipient is at least one of the following: excipient, filler, binder, wetting agent, disintegrant, absorption promoter, adsorbent carrier, surfactant, and lubricant.

[0017] According to a second aspect of the present invention, a method for preparing the above-mentioned traditional Chinese medicine composition for improving symptoms of liver stagnation and fire disturbing the heart is provided. When the dosage form of the traditional Chinese medicine composition for improving symptoms of liver stagnation and fire disturbing the heart is an oral solution, the preparation method includes the following steps:

[0018] Soak the raw materials in 8-12 times their weight of water for 20-40 minutes, then heat to boiling and maintain a gentle boil for 1-2 hours. Filter, and repeat the decoction process 1-2 times on the residue. Combine the filtrates to obtain the final product. The oral solution is further packaged after cooling, making it easy to carry and distribute.

[0019] According to a third aspect of the present invention, a method for preparing the above-mentioned traditional Chinese medicine composition for improving symptoms of liver stagnation transforming into fire disturbing the heart is provided. When the dosage form of the traditional Chinese medicine composition for improving symptoms of liver stagnation transforming into fire disturbing the heart is a powder, the preparation method includes the following steps:

[0020] Crush or chop each raw material separately, then pass the crushed or chopped raw materials through 10-mesh and 50-mesh sieves respectively. Continue to crush or chop the coarse particles that cannot pass through the 10-mesh sieve, and take the powder that is between the 10-mesh and 50-mesh sieves. Then mix the powders of each raw material according to the formula, put them into a packaging bag, and seal it.

[0021] According to a fourth aspect of the present invention, the use of the above-described traditional Chinese medicine composition for improving symptoms of liver stagnation and fire disturbing the heart is provided in the preparation of a medicament for improving symptoms of liver stagnation and fire disturbing the heart. Specifically, symptoms of liver stagnation and fire disturbing the heart include at least one of insomnia, excessive dreaming, palpitations, irritability, dry mouth, bitter taste in the mouth, oral ulcers, and distending discomfort in the hypochondrium.

[0022] The beneficial effects of this invention include:

[0023] (1) In the traditional Chinese medicine composition of the present invention for improving the symptoms of liver stagnation and fire disturbing the heart, Asparagus can nourish kidney yin and reduce heart fire; the heart is located in the upper jiao, and Chrysanthemum is light and clear, which can clear the heat of the upper jiao. Chrysanthemum enters the liver meridian and can clear the fire of the heart and liver at the same time. The combination of Imperata cylindrica root and Lophatherum gracile has the effect of clearing the heart and promoting diuresis, so that the fire is removed through urination. The combination of Citrus reticulata peel and Rose has the effect of regulating qi and relieving depression, avoiding qi stagnation and fire. At the same time, Citrus reticulata peel has the effect of warming the middle and drying dampness, avoiding cold drugs from damaging the spleen and stomach.

[0024] (2) The traditional Chinese medicine composition of the present invention for improving the symptoms of liver qi stagnation and fire disturbing the heart has the effects of clearing and moistening heart fire, relieving depression and irritability, calming the mind and aiding sleep. Clinical studies have shown that the traditional Chinese medicine composition of the present invention for improving the symptoms of liver qi stagnation and fire disturbing the heart can effectively improve symptoms such as insomnia, excessive dreaming, palpitations, irritability, dry mouth, bitter taste, oral ulcers, and hypochondriac distension caused by liver qi stagnation and fire disturbing the heart. Detailed Implementation

[0025] The present invention will be further described in detail below with reference to specific embodiments. It is worth noting that the following embodiments are only for better explaining the content of the present invention and do not limit the scope of protection of the present invention. Process steps not disclosed in the embodiments are prior art. Unless otherwise specified, all raw materials are commercially available.

[0026] Example 1

[0027] The oral solution of traditional Chinese medicine in this embodiment for improving symptoms of liver stagnation and fire disturbing the heart consists of the following ingredients: 5g of Asparagus cochinchinensis, 2g of Chrysanthemum morifolium, 5g of Imperata cylindrica root, 2g of Rose morifolium, 3g of Lophatherum gracile, and 3g of Citrus reticulata peel.

[0028] Its preparation method includes the following steps:

[0029] (1) Soak the raw materials in 10 times their weight of water for 30 minutes, then heat to boiling and keep simmering for 1 hour. After separation, the first decoction and the dregs are obtained. Take the dregs obtained after the first decoction, add water equivalent to 8 times the total mass of the raw materials, heat to boiling and keep simmering for 1 hour. After separation, the second decoction and the dregs are obtained. Combine the first decoction and the second decoction to obtain an oral solution.

[0030] (2) Cool the obtained oral solution and dispense it into individual containers. This ratio is for one dose, which is approximately 150 mL.

[0031] Example 2

[0032] The traditional Chinese medicine powder in this embodiment for improving symptoms of liver stagnation and fire disturbing the heart consists of the following ingredients: 5 grams of Asparagus root, 2 grams of Chrysanthemum, 5 grams of Imperata root, 2 grams of Rose, 3 grams of Lophatherum gracile, and 3 grams of Tangerine peel.

[0033] Its preparation method includes the following steps:

[0034] (1) Take asparagus and crush it. At the same time, pass it through a 10-mesh sieve and a 50-mesh sieve. Continue to crush the coarse particles that cannot pass through the 10-mesh sieve. Take the powder that is between the 10-mesh sieve and the 50-mesh sieve.

[0035] (2) Following the method in step (1), chrysanthemum, Imperata cylindrica root, rose, Lophatherum gracile and dried tangerine peel are pulverized into powder respectively;

[0036] (3) Mix all the raw material powders evenly, pack them into a sealed bag, and seal it. When taking it, mix it with about 150mL of warm water.

[0037] Example 3

[0038] The oral solution of traditional Chinese medicine in this embodiment for improving symptoms of liver stagnation and fire disturbing the heart consists of the following ingredients: 20g of Asparagus cochinchinensis, 9g of Chrysanthemum morifolium, 7g of Imperata cylindrica root, 3g of Rose morifolium, 7g of Lophatherum gracile, and 5g of Citrus reticulata peel.

[0039] Its preparation method is the same as that of Example 1.

[0040] Example 4

[0041] The traditional Chinese medicine powder in this embodiment for improving symptoms of liver stagnation and fire disturbing the heart consists of the following ingredients: 30g of Asparagus root, 15g of Chrysanthemum, 10g of Imperata root, 5g of Rose, 10g of Lophatherum gracile, and 6g of Tangerine peel.

[0042] Its preparation method is the same as that in Example 2.

[0043] Example of effect

[0044] The oral solution of traditional Chinese medicine prepared in Example 1 for improving symptoms of liver stagnation transforming into fire disturbing the heart was administered to individuals with this condition. The administration method was as follows: one dose per day, approximately 150 mL, taken twice daily (morning and evening), for 5 consecutive days. Information on gender, age, initial symptoms, and follow-up symptoms of 54 individuals with liver stagnation transforming into fire disturbing the heart was collected from April 11, 2025 to April 28, 2025, and their main symptoms were scored.

[0045] The 54 patients with liver qi stagnation transforming into fire and disturbing the heart were aged 23-77 years, with an average age of 52 years. Among them, 19 were male and 35 were female. Before medication, their main symptoms included insomnia, excessive dreaming, palpitations, irritability, dry mouth, bitter taste, oral ulcers, and distending pain in the hypochondrium. These symptoms were classified into four levels based on severity, with scores ranging from 1 to 4. The patients' symptoms before and after taking the oral solution of traditional Chinese medicine (TCM) described in Example 1 for improving liver qi stagnation transforming into fire and disturbing the heart were compared. The results are shown in Tables 1 and 2.

[0046] Table 1. Statistical analysis of the effects of oral Chinese medicine solutions for improving symptoms of liver stagnation and fire disturbing the heart on symptoms in individuals with liver stagnation and fire disturbing the heart ( ±s)

[0047]

[0048] Table 2. Statistical analysis of the effects of oral Chinese medicine solutions for improving symptoms of liver stagnation and fire disturbing the heart on symptoms in individuals with liver stagnation and fire disturbing the heart ( ±s)

[0049]

[0050] As can be seen from Tables 1 and 2, after taking the oral solution of the traditional Chinese medicine for improving symptoms of liver stagnation and fire disturbing the heart, the average scores of insomnia, excessive dreaming, palpitations, irritability, dry mouth, bitter taste, oral ulcers, and hypochondriac distension were significantly lower than before taking the medicine (P<0.05). This indicates that taking the traditional Chinese medicine composition of the present invention for improving symptoms of liver stagnation and fire disturbing the heart is significantly effective in improving symptoms such as insomnia, excessive dreaming, palpitations, irritability, dry mouth, bitter taste, oral ulcers, and hypochondriac distension in people with liver stagnation and fire disturbing the heart.

[0051] The above descriptions are merely some specific embodiments of the present invention. For those skilled in the art, various modifications and improvements can be made without departing from the inventive concept of the present invention, and all such modifications and improvements fall within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for improving symptoms of liver stagnation transforming into fire disturbing the heart, characterized in that, The raw material composition by weight is as follows: 5-30 parts asparagus, 2-15 parts chrysanthemum, 5-10 parts Imperata cylindrica root, 2-5 parts rose, 3-10 parts Lophatherum gracile, and 3-6 parts dried tangerine peel.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The dosage form of the traditional Chinese medicine composition is an oral solution, powder, or granule.

3. The traditional Chinese medicine composition according to claim 1 or 2, characterized in that, Pharmaceutically acceptable excipients can also be added.

4. The method for preparing the traditional Chinese medicine composition for improving symptoms of liver stagnation and fire disturbing the heart according to any one of claims 1-3, characterized in that, When the dosage form of the traditional Chinese medicine composition is an oral solution, its preparation method includes the following steps: Soak the raw materials in 8-12 times their weight of water for 20-40 minutes, then heat to boiling and maintain a gentle boil for 1-2 hours. Filter the mixture and boil the residue 1-2 times. Combine the filtrates to obtain the final product.

5. The method for preparing the traditional Chinese medicine composition for improving symptoms of liver stagnation and fire disturbing the heart according to any one of claims 1-3, characterized in that, When the dosage form of the traditional Chinese medicine composition is a powder, its preparation method includes the following steps: Crush or chop each raw material separately, then pass the crushed or chopped raw materials through 10-mesh and 50-mesh sieves respectively. Continue to crush or chop the coarse particles that cannot pass through the 10-mesh sieve, and take the powder that is between the 10-mesh and 50-mesh sieves. Then mix the powders of each raw material according to the formula, put them into a packaging bag, and seal it.

6. The use of the traditional Chinese medicine composition according to any one of claims 1-3 for improving symptoms of liver stagnation and fire disturbing the heart in the preparation of a medicament for improving symptoms of liver stagnation and fire disturbing the heart.

7. The application according to claim 6, characterized in that, The symptoms of liver stagnation transforming into fire and disturbing the heart include at least one of the following: insomnia, excessive dreaming, palpitations, irritability, dry mouth, bitter taste in the mouth, oral ulcers, and distending discomfort in the hypochondrium.

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