Anti-hair loss composition, application and anti-hair loss shampoo

Abstract

The invention relates to the technical field of daily chemicals, in particular to an anti-hair-loss composition, application and anti-hair-loss shampoo. The anti-hair loss composition is prepared from a cacumen biotae extract, cyclodextrin and maltodextrin. The anti-hair loss shampoo comprises a solvent, a surfactant, a hair conditioner, a humectant, a chelating agent and an anti-dandruff agent. A plurality of anti-hair-loss and hair-growing functional components such as the cacumen biotae extract and the ginseng root extract are jointly used in the formula and respectively act on different physiological links of hair follicles, such as improvement of microcirculation, activation of hair papilla cells, inhibition of 5alpha-reductase activity, delaying of hair follicle degeneration and the like; and a triple anti-hair loss path of nutrition supply, metabolic regulation and micro-inflammation relief is constructed, so that the synergistic promotion of hair loss prevention and hair growth is realized.

Description

Technical Field

[0001] The present invention relates to the technical field of daily chemicals, in particular to an anti-hair loss composition, application and anti-hair loss shampoo. Background Art

[0002] Currently, hair loss has become a widespread problem for human hair, with a clear trend of earlier onset and younger onset. Studies have shown that hair loss can be caused by a variety of factors, including but not limited to genetic factors, endocrine disorders, abnormal sebaceous gland secretion, chronic inflammation, mental stress, malnutrition, and improper hair care practices. Among them, androgenetic alopecia (AGA) and seborrheic alopecia are the most common, with an increasing incidence rate among men, seriously affecting quality of life and mental health.

[0003] There are many types of anti-hair loss shampoo products currently on the market, which are mainly designed through the following mechanisms:

[0004] 1. Oil-control cleansing type: By enhancing oil removal and improving the scalp environment, it reduces follicle blockage, thereby alleviating hair loss. Commonly used surfactants such as SLES, CAPB, and sodium lauroyl sarcosinate are combined with oil-control ingredients such as zinc pyrithione (ZPT), salicylic acid, and plant extracts;

[0005] 2. Nutritional conditioning type: Add a variety of plant active ingredients (such as ginseng, ginger root, arborvitae leaves, angelica, etc.) to stimulate hair growth by improving the nutrient supply of hair follicles;

[0006] 3. Active ingredients: such as niacinamide, caffeine, biotin, and raw thistle extract, which are used to activate hair follicle metabolism, improve microcirculation, and delay hair follicle atrophy;

[0007] 4. Mild and anti-allergic type: For sensitive scalps, it uses amino acid surfactant system, plant soothing ingredients, weak acid formula and other means to reduce the risk of aggravated hair loss caused by washing and care.

[0008] However, the existing anti-hair loss shampoo technology still has the following problems:

[0009] (1) Insufficient stability of active ingredients: For example, niacinamide is easily hydrolyzed into irritating niacin in an acidic environment, and plant extracts are prone to browning, precipitation, and degradation, resulting in decreased efficacy;

[0010] (2) Low absorption and utilization rate: Shampoo products are of the “short contact type” type, and the active ingredients are often difficult to stay and be absorbed due to the washing effect;

[0011] (3) Complex compatibility of active ingredients: adverse reactions may occur when caffeine and niacinamide coexist with certain preservatives and metal ions, affecting appearance and safety;

[0012] (4) It is difficult to strike a balance between cleansing and conditioning: Some oil-control or anti-dandruff shampoos sacrifice mildness in pursuit of cleansing power, which damages the scalp barrier and aggravates the trend of hair loss.

[0013] Therefore, there is an urgent need to develop an anti-hair loss shampoo product that is stable, absorbent, mild, and has multiple synergistic mechanisms. It can not only improve the scalp microenvironment, but also enhance the functional activity of hair follicles, achieve a scientific balance between cleaning, maintenance, and hair loss prevention, and improve actual use effects and consumer satisfaction. Summary of the Invention

[0014] In order to solve the above technical problems, the present invention provides an anti-hair loss composition, which comprises: Thuja orientalis (Thujaorientalis) leaf extract, cyclodextrin, and maltodextrin.

[0015] As an embodiment of the present invention, the cyclodextrin is a mixture of hydroxypropyl-β-cyclodextrin and methyl-β-cyclodextrin.

[0016] As an embodiment of the present invention, the anti-hair loss composition further comprises ethoxydiglycol and 1,2-hexanediol.

[0017] As an embodiment of the present invention, the anti-hair loss composition further comprises ginseng (PANAXGINSENG) root extract, ethoxydiglycol, 1,2-pentanediol, PEG-40 hydrogenated castor oil and 1,2-hexanediol.

[0018] As an embodiment of the present invention, the anti-hair loss composition is used in the field of daily chemicals.

[0019] The present invention provides an anti-hair loss shampoo comprising the anti-hair loss composition.

[0020] As an embodiment of the present invention, the raw materials for its preparation include: a solvent, a surfactant, a hair conditioner, a moisturizer, a chelating agent, an anti-dandruff agent, and the anti-hair loss composition.

[0021] As an embodiment of the present invention, the hair conditioner comprises sodium laureth sulfate, hydrolyzed corn starch, guar hydroxypropyltrimonium chloride, allantoin, creatine, ANGELICA ACUTILOBA root extract, sodium lauroyl oat amino acids and hydroxydecanoic acid.

[0022] As an embodiment of the present invention, the surfactant includes sodium lauroyl sarcosinate, sodium lauroyl glutamate, lauryl diethylenediaminoglycine, sodium laureth sulfate, and ammonium lauryl sulfate.

[0023] As an embodiment of the present invention, the pH value of the shampoo is 5.5 to 6.2.

[0024] By adopting the above technical solution, the present invention has the following beneficial effects:

[0025] 1. Multiple anti-hair loss mechanisms work together to improve efficacy

[0026] The present invention combines a variety of anti-hair loss and hair growth ingredients such as Platycladus orientalis leaf extract, ginseng root extract, etc. in the formula, which act on different physiological links of hair follicles, such as improving microcirculation, activating hair papilla cells, inhibiting 5α-reductase activity, delaying the hair follicle regression period, etc., constructing a triple anti-hair loss path of "nutritional supply-metabolic regulation-micro-inflammation relief", and achieving synergistic promotion of hair loss prevention and hair growth.

[0027] 2. Build a surfactant system that balances cleansing and mildness

[0028] The present invention uses sodium laureth sulfate (SLES) and cocamidopropyl betaine (CAPB) in a compound, and further introduces an amino acid surfactant, such as sodium lauroyl glutamate or sodium lauroyl sarcosinate, to form a composite cleaning system with low irritation, rich foam, and moderate cleaning power. While effectively removing excess sebum and dandruff, it can maintain the stability of the scalp barrier and avoid mechanical or chemical irritation caused by the washing process.

[0029] 3. Enhance the stability and release ability of active ingredients

[0030] The present invention uses cyclodextrin inclusion technology to microencapsulate plant active ingredients, which can significantly improve the water solubility and light and heat stability of flavonoids and volatile oil components; at the same time, the formula is equipped with a polyol solubility system (such as ethoxydiglycol, 1,2-hexanediol, etc.), which can synergistically promote the dispersion and gradual release of the inclusion complex, improve the contact efficiency between the effective ingredients and the scalp during the shampooing process, and thus enhance their penetration and absorption effect.

[0031] 4. Has good hair smoothness and skin feel

[0032] The present invention introduces cationic conditioning agents such as guar hydroxypropyltrimonium chloride, which can bind to the negatively charged keratin on the hair surface, significantly improving wet and dry combing after washing, reducing static adhesion, and enhancing hair smoothness. It can also replace part of the silicone oil to create a silicone-free, lightweight, and residue-free scalp care environment, which better meets the needs of modern consumers for healthy hair care products.

[0033] 5. Mild pH value, adapted to the physiological needs of the scalp

[0034] The present invention uses a reasonable pH adjustment system to stably control the pH value of the finished shampoo between 5.5 and 6.2, which is consistent with the weakly acidic ecological environment of a healthy scalp, helps maintain the balance of the sebum membrane, reduces water loss in the stratum corneum, and is beneficial to the stability and bioavailability of active ingredients such as niacinamide, thereby reducing potential irritation risks and improving safety and comfort of use.

[0035] 6. Good compatibility, excellent product appearance and storage stability

[0036] The present invention optimizes system compatibility and controls the compatibility ratio, thereby ensuring good stability among multiple components such as plant extracts, alcohol cosolvents, surfactant systems, and cationic conditioning agents, without obvious precipitation, stratification, discoloration, and other problems. The finished product is a transparent to microemulsion liquid with a natural odor, remains clear after storage for more than 12 months at room temperature, and has qualified physical and chemical indicators, thus having good adaptability to industrial production. DETAILED DESCRIPTION

[0037] The anti-hair loss composition comprises: Thuja orientalis leaf extract, cyclodextrin and maltodextrin.

[0038] The cyclodextrin is a mixture of hydroxypropyl-β-cyclodextrin and methyl-β-cyclodextrin. The anti-hair loss composition further comprises ethoxydiglycol and 1,2-hexanediol.

[0039] The anti-hair loss composition further comprises ginseng root extract, ethoxydiglycol, 1,2-pentanediol, PEG-40 hydrogenated castor oil and 1,2-hexanediol.

[0040] As an embodiment of the present invention, the anti-hair loss composition is used in the field of daily chemicals.

[0041] The invention provides an anti-hair loss shampoo. The raw materials for preparing the shampoo comprise: a solvent, a surfactant, a hair conditioner, a moisturizer, a chelating agent, an anti-dandruff agent and the anti-hair loss composition.

[0042] More preferably, the preparation raw materials include:

[0043] Component 1: Water to 100 parts. Component 2: Sodium Laureth Sulfate 9.0 parts, Water 4.0 parts. Component 3: Water 5.24 parts, Cocamidopropyl Betaine 2.36 parts, Sodium Chloride 0.36 parts, Sodium Benzoate 0.04 parts. Component 4: Water 2.1 parts, Sodium Lauroyl Sarcosinate 0.894 parts, Sodium Lauroyl Glutamate 0.003 parts, Lauryl Diethylenediaminoglycine 0.003 parts. Component 5: Water 1.67 parts, Ethoxydiglycol 0.2 parts, Pentylene Glycol 0.05 parts, PEG-40 Hydrogenated Castor Oil 0.04 parts, 1,2-Hexanediol 0.02 parts, Panax Ginseng Root Extract 0.09 parts. Component 6: Dimethicone 0.83 parts, Water 0.2472 parts, Sodium Laureth Sulfate 0.1018 parts, Sodium Chloride 0.012 parts. Component 7: Cocamide MEA 0.92 parts, Methyl Cocoate 0.05 parts. Component 8: Thuja orientalis (Thuja orientalis) Leaf Extract 1.0 parts, Cyclodextrin 0.15 parts, Maltodextrin 0.15 parts, Ethoxydiglycol 0.02 parts, 1,2-Hexanediol 0.01 parts. Component 9: Water 0.5832 parts, Ammonium Lauryl Sulfate 0.08 parts, Hydrogenated Castor Oil 0.064 parts, Cocamide MEA 0.064 parts, Phenoxyethanol 0.0072 parts, Disodium EDTA 0.0008 parts, Sodium Benzoate 0.0008 parts. Component 10: Hydrolyzed Corn Starch 0.75 parts, Water 0.04 parts, Phenoxyethanol 0.006 parts. Component 11: Sodium Chloride 0.8 parts. Component 12: Fragrance (Daily Use) 0.5 parts. Component 13: Phenoxyethanol 0.4 parts. Component 14: Phenoxyethanol 0.162%, Dichlorobenzyl Alcohol 0.09%, Sodium Isostearyl Lactylate 0.03%, Ethylhexylglycerin 0.018%. Component 15: Sodium Benzoate 0.3%. Component 16: Guar Hydroxypropyltrimonium Chloride 0.255%, Water 0.03%, Sodium Chloride 0.015%. Component 17: Adenosine 0.25%. Component 18: Niacinamide 0.2%. Component 19: Allantoin 0.1275%, Creatine 0.0225%. Component 20: Panthenol 0.15%. Component 21: Taurine 0.13%. Component 22: Citric Acid 0.12%. Component 23: Angelica Cautilloba Root Extract 0.00376%, Butylene Glycol 0.04812%, Water 0.04812. Component 24: Sodium Lauroyl Oat Amino Acids 0.03%, Water 0.0685%, Phenoxyethanol 0.0009%, Ethylhexylglycerin 0.0001%, Tetrasodium EDTA 0.0005%. Component 25: Piroctone Olanthamine 0.1%. Component 26: Disodium EDTA 0.1%. Component 27: Hydroxydecanoic Acid 0.05%. Component 28: Ginsenosides 0.009%.

[0044] The anti-shedding composition comprises component 8 and component 5; and the preparation method of the anti-shedding composition is as follows:

[0045] 1. Mix cyclodextrin and maltodextrin with water respectively and heat to 40℃ to fully dissolve; obtain hydroxypropyl-β-cyclodextrin aqueous solution, methyl-β-cyclodextrin aqueous solution and maltodextrin aqueous solution respectively.

[0046] 2. Mix the Platycladus orientalis leaf extract, ethoxydiglycol and 1,2-hexanediol in component 8; then add the methyl-β-cyclodextrin aqueous solution and stir evenly; then add the hydroxypropyl-β-cyclodextrin aqueous solution in turn and stir to react for 1 to 2 hours, let it stand and filter; add the maltodextrin aqueous solution and it is done.

[0047] The mass ratio of hydroxypropyl-β-cyclodextrin to methyl-β-cyclodextrin in the present invention is 3:1.

[0048] As an embodiment of the present invention, the preparation method of the Platycladus orientalis leaf extract is as follows:

[0049] (1) Crushing treatment: Take the dried Platycladus orientalis leaves and grind them into 30-60 mesh coarse powder;

[0050] (2) Preparation of pretreatment solution: 30% ethanol + 0.1% cellulase + 0.1% pectinase + pH 5.5 buffer

[0051] (3) The material-liquid ratio is 1:10. After adding the crude powder of Platycladus orientalis leaves, the mixture is heated at 45°C, stirred for 60 minutes, and then heated to 85°C for 10-15 minutes to inactivate the enzyme.

[0052] (4) Based on step (3), an equal volume of 60% ethanol (v / v) and 5% 1,2-pentanediol (w / v) were added, and the mixture was extracted in a 40°C water bath with magnetic stirring for 30 minutes;

[0053] (5) Then add 0.05% tocopherol acetate, 0.05% sodium ascorbate, and 0.05% EDTA-2Na, stir evenly, and place in a refrigerator at 4°C for 12 hours (to remove precipitates or floating matter); then use a rotary evaporator to reduce pressure and concentrate to about 1 / 3 of the volume at 45°C and 300 mbar.

[0054] Platycladus orientalis leaf extract often contains a variety of active ingredients such as flavonoids (such as quercetin), volatile oils, tannins, and many other active ingredients, many of which are hydrophobic or unstable. In order to improve their stability, solubility and odor control, cyclodextrin is usually used for inclusion treatment. Cyclodextrin inclusion may lead to slow or incomplete release of active ingredients, especially in short-contact products such as shampoo, affecting the actual efficacy. Therefore, the present invention has made some improvements to the extraction method of Platycladus orientalis leaf extract, and adjusted the inclusion method of Platycladus orientalis leaf extract and cyclodextrin,

[0055] The combination of hydroxypropyl-β-cyclodextrin (HP-β-CD) and methyl-β-cyclodextrin (M-β-CD) not only offers high water solubility and moderate inclusion strength, allowing for easy release in shampoo, but is also suitable for volatile ingredients. Furthermore, the addition of a cosolvent during inclusion can adjust inclusion stability and promote release. Furthermore, during the preparation of Platycladus orientalis leaf extract, the enzymatic hydrolysis-assisted step primarily releases flavonoids (such as quercetin derivatives) and volatile terpenoids (such as thujone). These small, hydrophobic molecules are well-suited for entrapment within the hydrophobic cavity of cyclodextrin. The addition of 1,2-pentanediol acts as a "molecular bridge," distributing the hydrophobic components in the aqueous phase as micelles or micromolecules, greatly increasing the chances of encounter between the extract and cyclodextrin and promoting inclusion formation. Flavonoids are prone to oxidation and polymerization into larger molecules in unstable environments, preventing them from entering the CD cavity. The triple protection provided by sodium ascorbate, tocopherol, and EDTA preserves the activity of the flavonoid monomers and maintains the integrity of the inclusion active.

[0056] As an embodiment of the present invention, the preparation steps of the shampoo are as follows:

[0057] S01 classifies the components of shampoo:

[0058] Phase A: 1 / 3 component 1, component 2, component 19, component 16, component 26, component 22, component 15

[0059] Phase B: component 3, component 4, component 7, component 17, component 18, component 21, component 27, 1 / 2 component 28

[0060] Phase C: component 5, component 6, component 9, component 10, component 14, component 20, component 23, component 24

[0061] Phase D: 1 / 3 component 1, component 8, remaining component 28

[0062] Phase E: Component 12, Component 13, Component 25

[0063] Phase F: Remaining component 1, component 11

[0064] S02: Add the materials of phase A into the main pot in sequence, heat and stir until the materials are completely dissolved. Control the temperature at 80-95℃, then add the materials of phase B into the pot in sequence, stir until completely dissolved, keep warm (75-80℃) and stir for 20 minutes;

[0065] S03 After the materials in the pot are completely dissolved, start stirring and cool to 45℃, add the C phase materials in sequence and stir evenly. Continue to cool to 40℃, disperse and dissolve the D phase evenly, add it to the pot and stir evenly, then add the E phase materials in sequence and stir evenly;

[0066] Add the evenly dispersed and dissolved F phase into S04 at 35℃ and stir evenly. Adjust to suitable viscosity and conduct sampling inspection. If qualified, the material can be discharged and stored.

[0067] The present invention will be further explained below with reference to specific embodiments.

[0068] Example 1

[0069] On one hand, this embodiment provides an anti-hair loss composition comprising: Thuja orientalis leaf extract, ginseng root extract, ethoxydiglycol, 1,2-pentanediol, PEG-40 hydrogenated castor oil and 1,2-hexanediol.

[0070] On the other hand, an anti-hair loss shampoo is provided, the raw materials for its preparation comprising:

[0071] Component 1: Water to 100 parts. Component 2: Sodium Laureth Sulfate 9.0 parts, Water 4.0 parts. Component 3: Water 5.24 parts, Cocamidopropyl Betaine 2.36 parts, Sodium Chloride 0.36 parts, Sodium Benzoate 0.04 parts. Component 4: Water 2.1 parts, Sodium Lauroyl Sarcosinate 0.89 parts, Sodium Lauroyl Glutamate 0.003 parts, Lauryl Diethylenediaminoglycine 0.003 parts. Component 5: Water 1.67 parts, Ethoxydiglycol 0.2 parts, Pentylene Glycol 0.05 parts, PEG-40 Hydrogenated Castor Oil 0.04 parts, 1,2-Hexanediol 0.02 parts, Panax Ginseng Root Extract 0.09 parts. Component 6: Dimethicone 0.83 parts, Water 0.2472 parts, Sodium Laureth Sulfate 0.1018 parts, Sodium Chloride 0.012 parts. Component 7: Cocamide MEA 0.92 parts, Methyl Cocoate 0.05 parts. Component 8: Thuja orientalis (Thuja orientalis) Leaf Extract 1.0 parts, Ethoxydiglycol 0.02 parts, 1,2-Hexanediol 0.01 parts. Component 9: Water 0.5832 parts, Ammonium Lauryl Sulfate 0.08 parts, Hydrogenated Castor Oil 0.064 parts, Cocamide MEA 0.064 parts, Phenoxyethanol 0.0072 parts, Disodium EDTA 0.0008 parts, Sodium Benzoate 0.0008 parts. Component 10: Hydrolyzed Corn Starch 0.75 parts, Water 0.04 parts, Phenoxyethanol 0.006 parts. Component 11: Sodium Chloride 0.8 parts. Component 12: Fragrance (Daily Use) 0.5 parts. Component 13: Phenoxyethanol 0.4 parts. Component 14: Phenoxyethanol 0.162%, Dichlorobenzyl Alcohol 0.09%, Sodium Isostearyl Lactylate 0.03%, Ethylhexylglycerin 0.018%. Component 15: Sodium Benzoate 0.3%. Component 16: Guar Hydroxypropyltrimonium Chloride 0.255%, Water 0.03%, Sodium Chloride 0.015%. Component 17: Adenosine 0.25%. Component 18: Niacinamide 0.2%. Component 19: Allantoin 0.1275%, Creatine 0.0225%. Component 20: Panthenol 0.15%. Component 21: Taurine 0.13%. Component 22: Citric Acid 0.12%. Component 23: Angelica Cautilloba Root Extract 0.00376%, Butylene Glycol 0.04812%, Water 0.04812. Component 24: Sodium Lauroyl Oat Amino Acids 0.03%, Water 0.0685%, Phenoxyethanol 0.0009%, Ethylhexylglycerin 0.0001%, Tetrasodium EDTA 0.0005%. Component 25: Piroctone Olanthamine 0.1%. Component 26: Disodium EDTA 0.1%. Component 27: Hydroxydecanoic Acid 0.05%. Component 28: Ginsenosides 0.009%.

[0072] The preparation method of the Platycladus orientalis leaf extract is as follows:

[0073] (1) Crushing treatment: Take the dried Platycladus orientalis leaves and grind them into 30-60 mesh coarse powder;

[0074] (2) Prepare a pretreatment solution: 30 vol% ethanol, 0.1 wt% cellulase, 0.1 wt% pectinase, pH 5.5 0.05 M citric acid-phosphate buffer;

[0075] (3) The material-liquid ratio is 1:10. After adding the crude powder of Platycladus orientalis leaves, the mixture is heated at 45°C, stirred for 60 minutes, and then heated to 85°C for 10-15 minutes to inactivate the enzyme.

[0076] (4) Based on step (3), an equal volume of 60% ethanol and 5% 1,2-pentanediol (w / v) were added, and the mixture was extracted in a 40°C water bath with magnetic stirring for 30 minutes;

[0077] (5) Then add 0.05% tocopherol acetate, 0.05% sodium ascorbate, and 0.05% EDTA-2Na, stir evenly, and place in a refrigerator at 4°C for 12 hours (to remove precipitates or floating matter); then use a rotary evaporator to reduce pressure and concentrate to about 1 / 3 of the volume at 45°C and 300 mbar.

[0078] The preparation steps of the shampoo are as follows:

[0079] S01 classifies the components of shampoo:

[0080] Phase A: 1 / 3 component 1, component 2, component 19, component 16, component 26, component 22, component 15

[0081] Phase B: component 3, component 4, component 7, component 17, component 18, component 21, component 27, 1 / 2 component 28

[0082] Phase C: component 5, component 6, component 9, component 10, component 14, component 20, component 23, component 24

[0083] Phase D: 1 / 3 component 1, component 8, remaining component 28

[0084] Phase E: Component 12, Component 13, Component 25

[0085] Phase F: Remaining component 1, component 11

[0086] S02: Add the materials of phase A into the main pot in sequence, heat and stir until the materials are completely dissolved. Control the temperature at 80-95℃, then add the materials of phase B into the pot in sequence, stir until completely dissolved, keep warm (75-80℃) and stir for 20 minutes;

[0087] S03 After the materials in the pot are completely dissolved, start stirring and cool to 45℃, add the C phase materials in sequence and stir evenly. Continue to cool to 40℃, disperse and dissolve the D phase evenly, add it to the pot and stir evenly, then add the E phase materials in sequence and stir evenly;

[0088] Add the evenly dispersed and dissolved F phase into S04 at 35℃ and stir evenly. Adjust to suitable viscosity and conduct sampling inspection. If qualified, the material can be discharged and stored.

[0089] Example 2

[0090] On one hand, this embodiment provides an anti-hair loss composition comprising: Thuja orientalis leaf extract, ginseng root extract, ethoxydiglycol, 1,2-pentanediol, PEG-40 hydrogenated castor oil and 1,2-hexanediol.

[0091] On the other hand, an anti-hair loss shampoo is provided, the raw materials for its preparation comprising:

[0092] Component 1: Water to 100 parts. Component 2: Sodium Laureth Sulfate 9.0 parts, Water 4.0 parts. Component 3: Water 5.24 parts, Cocamidopropyl Betaine 2.36 parts, Sodium Chloride 0.36 parts, Sodium Benzoate 0.04 parts. Component 4: Water 2.1 parts, Sodium Lauroyl Sarcosinate 0.89 parts, Sodium Lauroyl Glutamate 0.003 parts, Lauryl Diethylenediaminoglycine 0.003 parts. Component 5: Water 1.67 parts, Ethoxydiglycol 0.2 parts, Pentylene Glycol 0.05 parts, PEG-40 Hydrogenated Castor Oil 0.04 parts, 1,2-Hexanediol 0.02 parts, Panax Ginseng Root Extract 0.09 parts. Component 6: Dimethicone 0.83 parts, Water 0.2472 parts, Sodium Laureth Sulfate 0.1018 parts, Sodium Chloride 0.012 parts. Component 7: Cocamide MEA 0.92 parts, Methyl Cocoate 0.05 parts. Component 8: Thuja orientalis (Thuja orientalis) Leaf Extract 1.0 parts, Cyclodextrin 0.15 parts, Maltodextrin 0.15 parts, Ethoxydiglycol 0.02 parts, 1,2-Hexanediol 0.01 parts. Component 9: Water 0.5832 parts, Ammonium Lauryl Sulfate 0.08 parts, Hydrogenated Castor Oil 0.064 parts, Cocamide MEA 0.064 parts, Phenoxyethanol 0.0072 parts, Disodium EDTA 0.0008 parts, Sodium Benzoate 0.0008 parts. Component 10: Hydrolyzed Corn Starch 0.75 parts, Water 0.04 parts, Phenoxyethanol 0.006 parts. Component 11: Sodium Chloride 0.8 parts. Component 12: Fragrance (Daily Use) 0.5 parts. Component 13: Phenoxyethanol 0.4 parts. Component 14: Phenoxyethanol 0.162%, Dichlorobenzyl Alcohol 0.09%, Sodium Isostearyl Lactylate 0.03%, Ethylhexylglycerin 0.018%. Component 15: Sodium Benzoate 0.3%. Component 16: Guar Hydroxypropyltrimonium Chloride 0.255%, Water 0.03%, Sodium Chloride 0.015%. Component 17: Adenosine 0.25%. Component 18: Niacinamide 0.2%. Component 19: Allantoin 0.1275%, Creatine 0.0225%. Component 20: Panthenol 0.15%. Component 21: Taurine 0.13%. Component 22: Citric Acid 0.12%. Component 23: Angelica Cautilloba Root Extract 0.00376%, Butylene Glycol 0.04812%, Water 0.04812. Component 24: Sodium Lauroyl Oat Amino Acids 0.03%, Water 0.0685%, Phenoxyethanol 0.0009%, Ethylhexylglycerin 0.0001%, Tetrasodium EDTA 0.0005%. Component 25: Piroctone Olanthamine 0.1%. Component 26: Disodium EDTA 0.1%. Component 27: Hydroxydecanoic Acid 0.05%. Component 28: Ginsenosides 0.009%.

[0093] The anti-shedding composition comprises component 8 and component 5; and the preparation method of the anti-shedding composition is as follows:

[0094] 1. Mix cyclodextrin and maltodextrin with water respectively, and heat to 40°C to fully dissolve; obtain 10 wt% aqueous solution of hydroxypropyl-β-cyclodextrin and 5 wt% aqueous solution of maltodextrin respectively.

[0095] 2. Mix the Platycladus orientalis leaf extract, ethoxydiglycol and 1,2-hexanediol in component 8; then add the methyl-β-cyclodextrin aqueous solution and stir evenly; then add the hydroxypropyl-β-cyclodextrin aqueous solution in turn and stir to react for 1 to 2 hours, let it stand and filter; add the maltodextrin aqueous solution and it is done.

[0096] The preparation method of the Platycladus orientalis leaf extract is as follows:

[0097] (1) Crushing treatment: Take the dried Platycladus orientalis leaves and grind them into 30-60 mesh coarse powder;

[0098] (2) Preparation of pretreatment solution: 30% ethanol + 0.1% cellulase + 0.1% pectinase + pH 5.5 buffer

[0099] (3) The material-liquid ratio is 1:10. After adding the crude powder of Platycladus orientalis leaves, the mixture is heated at 45°C, stirred for 60 minutes, and then heated to 85°C for 10-15 minutes to inactivate the enzyme.

[0100] (4) Based on step (3), an equal volume of 60% ethanol (v / v) and 5% 1,2-pentanediol (w / v) were added, and the mixture was extracted in a 40°C water bath with magnetic stirring for 30 minutes;

[0101] (5) Then add 0.05% tocopherol acetate, 0.05% sodium ascorbate, and 0.05% EDTA-2Na, stir evenly, and place in a refrigerator at 4°C for 12 hours (to remove precipitates or floating matter); then use a rotary evaporator to reduce pressure and concentrate to about 1 / 3 of the volume at 45°C and 300 mbar.

[0102] The preparation steps of the shampoo are as follows:

[0103] S01 classifies the components of shampoo:

[0104] Phase A: 1 / 3 component 1, component 2, component 19, component 16, component 26, component 22, component 15

[0105] Phase B: component 3, component 4, component 7, component 17, component 18, component 21, component 27, 1 / 2 component 28

[0106] Phase C: component 5, component 6, component 9, component 10, component 14, component 20, component 23, component 24

[0107] Phase D: 1 / 3 component 1, component 8, remaining component 28

[0108] Phase E: Component 12, Component 13, Component 25

[0109] Phase F: Remaining component 1, component 11

[0110] S02: Add the materials of phase A into the main pot in sequence, heat and stir until the materials are completely dissolved. Control the temperature at 80-95℃, then add the materials of phase B into the pot in sequence, stir until completely dissolved, keep warm (75-80℃) and stir for 20 minutes;

[0111] S03 After the materials in the pot are completely dissolved, start stirring and cool to 45℃, add the C phase materials in sequence and stir evenly. Continue to cool to 40℃, disperse and dissolve the D phase evenly, add it to the pot and stir evenly, then add the E phase materials in sequence and stir evenly;

[0112] Add the evenly dispersed and dissolved F phase into S04 at 35℃ and stir evenly. Adjust to suitable viscosity and conduct sampling inspection. If qualified, the material can be discharged and stored.

[0113] Example 3

[0114] On one hand, this embodiment provides an anti-hair loss composition comprising: Thuja orientalis leaf extract, ginseng root extract, ethoxydiglycol, 1,2-pentanediol, PEG-40 hydrogenated castor oil and 1,2-hexanediol.

[0115] On the other hand, an anti-hair loss shampoo is provided, the raw materials for its preparation comprising:

[0116] Component 1: Water to 100 parts. Component 2: Sodium Laureth Sulfate 9.0 parts, Water 4.0 parts. Component 3: Water 5.24 parts, Cocamidopropyl Betaine 2.36 parts, Sodium Chloride 0.36 parts, Sodium Benzoate 0.04 parts. Component 4: Water 2.1 parts, Sodium Lauroyl Sarcosinate 0.89 parts, Sodium Lauroyl Glutamate 0.003 parts, Lauryl Diethylenediaminoglycine 0.003 parts. Component 5: Water 1.67 parts, Ethoxydiglycol 0.2 parts, Pentylene Glycol 0.05 parts, PEG-40 Hydrogenated Castor Oil 0.04 parts, 1,2-Hexanediol 0.02 parts, Panax Ginseng Root Extract 0.09 parts. Component 6: Dimethicone 0.83 parts, Water 0.2472 parts, Sodium Laureth Sulfate 0.1018 parts, Sodium Chloride 0.012 parts. Component 7: Cocamide MEA 0.92 parts, Methyl Cocoate 0.05 parts. Component 8: Thuja orientalis (Thuja orientalis) Leaf Extract 1.0 parts, Cyclodextrin 0.15 parts, Maltodextrin 0.15 parts, Ethoxydiglycol 0.02 parts, 1,2-Hexanediol 0.01 parts. Component 9: Water 0.5832 parts, Ammonium Lauryl Sulfate 0.08 parts, Hydrogenated Castor Oil 0.064 parts, Cocamide MEA 0.064 parts, Phenoxyethanol 0.0072 parts, Disodium EDTA 0.0008 parts, Sodium Benzoate 0.0008 parts. Component 10: Hydrolyzed Corn Starch 0.75 parts, Water 0.04 parts, Phenoxyethanol 0.006 parts. Component 11: Sodium Chloride 0.8 parts. Component 12: Fragrance (Daily Use) 0.5 parts. Component 13: Phenoxyethanol 0.4 parts. Component 14: Phenoxyethanol 0.162%, Dichlorobenzyl Alcohol 0.09%, Sodium Isostearyl Lactylate 0.03%, Ethylhexylglycerin 0.018%. Component 15: Sodium Benzoate 0.3%. Component 16: Guar Hydroxypropyltrimonium Chloride 0.255%, Water 0.03%, Sodium Chloride 0.015%. Component 17: Adenosine 0.25%. Component 18: Niacinamide 0.2%. Component 19: Allantoin 0.1275%, Creatine 0.0225%. Component 20: Panthenol 0.15%. Component 21: Taurine 0.13%. Component 22: Citric Acid 0.12%. Component 23: Angelica Cautilloba Root Extract 0.00376%, Butylene Glycol 0.04812%, Water 0.04812. Component 24: Sodium Lauroyl Oat Amino Acids 0.03%, Water 0.0685%, Phenoxyethanol 0.0009%, Ethylhexylglycerin 0.0001%, Tetrasodium EDTA 0.0005%. Component 25: Piroctone Olanthamine 0.1%. Component 26: Disodium EDTA 0.1%. Component 27: Hydroxydecanoic Acid 0.05%. Component 28: Ginsenosides 0.009%.

[0117] The anti-shedding composition comprises component 8 and component 5; and the preparation method of the anti-shedding composition is as follows:

[0118] 1. Mix cyclodextrin and maltodextrin with water respectively and heat to 40°C to fully dissolve; obtain 10 wt% aqueous solution of hydroxypropyl-β-cyclodextrin, 10 wt% aqueous solution of methyl-β-cyclodextrin and 5 wt% aqueous solution of maltodextrin respectively.

[0119] 2. Mix the Platycladus orientalis leaf extract, ethoxydiglycol and 1,2-hexanediol in component 8; then add the methyl-β-cyclodextrin aqueous solution and stir evenly; then add the hydroxypropyl-β-cyclodextrin aqueous solution in turn and stir to react for 1 to 2 hours, let it stand and filter; add the maltodextrin aqueous solution and it is done.

[0120] The mass ratio of hydroxypropyl-β-cyclodextrin to methyl-β-cyclodextrin in the present invention is 1:3.

[0121] The preparation method of the Platycladus orientalis leaf extract is as follows:

[0122] (1) Crushing treatment: Take the dried Platycladus orientalis leaves and grind them into 30-60 mesh coarse powder;

[0123] (2) Preparation of pretreatment solution: 30% ethanol + 0.1% cellulase + 0.1% pectinase + pH 5.5 buffer

[0124] (3) The material-liquid ratio is 1:10. After adding the crude powder of Platycladus orientalis leaves, the mixture is heated at 45°C, stirred for 60 minutes, and then heated to 85°C for 10-15 minutes to inactivate the enzyme.

[0125] (4) Based on step (3), an equal volume of 60% ethanol (v / v) and 5% 1,2-pentanediol (w / v) were added, and the mixture was extracted in a 40°C water bath with magnetic stirring for 30 minutes;

[0126] (5) Then add 0.05% tocopherol acetate, 0.05% sodium ascorbate, and 0.05% EDTA-2Na, stir evenly, and place in a refrigerator at 4°C for 12 hours (to remove precipitates or floating matter); then use a rotary evaporator to reduce pressure and concentrate to about 1 / 3 of the volume at 45°C and 300 mbar.

[0127] The preparation steps of the shampoo are as follows:

[0128] S01 classifies the components of shampoo:

[0129] Phase A: 1 / 3 component 1, component 2, component 19, component 16, component 26, component 22, component 15

[0130] Phase B: component 3, component 4, component 7, component 17, component 18, component 21, component 27, 1 / 2 component 28

[0131] Phase C: component 5, component 6, component 9, component 10, component 14, component 20, component 23, component 24

[0132] Phase D: 1 / 3 component 1, component 8, remaining component 28

[0133] Phase E: Component 12, Component 13, Component 25

[0134] Phase F: Remaining component 1, component 11

[0135] S02: Add the materials of phase A into the main pot in sequence, heat and stir until the materials are completely dissolved. Control the temperature at 80-95℃, then add the materials of phase B into the pot in sequence, stir until completely dissolved, keep warm (75-80℃) and stir for 20 minutes;

[0136] S03 After the materials in the pot are completely dissolved, start stirring and cool to 45℃, add the C phase materials in sequence and stir evenly. Continue to cool to 40℃, disperse and dissolve the D phase evenly, add it to the pot and stir evenly, then add the E phase materials in sequence and stir evenly;

[0137] Add the evenly dispersed and dissolved F phase into S04 at 35℃ and stir evenly. Adjust to suitable viscosity and conduct sampling inspection. If qualified, the material can be discharged and stored.

[0138] Example 4

[0139] On one hand, this embodiment provides an anti-hair loss composition comprising: Thuja orientalis leaf extract, ginseng root extract, ethoxydiglycol, 1,2-pentanediol, PEG-40 hydrogenated castor oil and 1,2-hexanediol.

[0140] On the other hand, an anti-hair loss shampoo is provided, the raw materials for its preparation comprising:

[0141] Component 1: Water to 100 parts. Component 2: Sodium Laureth Sulfate 9.0 parts, Water 4.0 parts. Component 3: Water 5.24 parts, Cocamidopropyl Betaine 2.36 parts, Sodium Chloride 0.36 parts, Sodium Benzoate 0.04 parts. Component 4: Water 2.1 parts, Sodium Lauroyl Sarcosinate 0.89 parts, Sodium Lauroyl Glutamate 0.003 parts, Lauryl Diethylenediaminoglycine 0.003 parts. Component 5: Water 1.67 parts, Ethoxydiglycol 0.2 parts, Pentylene Glycol 0.05 parts, PEG-40 Hydrogenated Castor Oil 0.04 parts, 1,2-Hexanediol 0.02 parts, Panax Ginseng Root Extract 0.09 parts. Component 6: Dimethicone 0.83 parts, Water 0.2472 parts, Sodium Laureth Sulfate 0.1018 parts, Sodium Chloride 0.012 parts. Component 7: Cocamide MEA 0.92 parts, Methyl Cocoate 0.05 parts. Component 8: Thuja orientalis (Oriental Platycladus Orientalis) Leaf Extract 1.0 parts, Cyclodextrin 0.15 parts, Maltodextrin 0.15 parts. Component 9: Water 0.5832 parts, Ammonium Lauryl Sulfate 0.08 parts, Hydrogenated Castor Oil 0.064 parts, Cocamide MEA 0.064 parts, Phenoxyethanol 0.0072 parts, Disodium EDTA 0.0008 parts, Sodium Benzoate 0.0008 parts. Component 10: Hydrolyzed Corn Starch 0.75 parts, Water 0.04 parts, Phenoxyethanol 0.006 parts. Component 11: Sodium Chloride 0.8 parts. Component 12: Fragrance (Daily Use) 0.5 parts. Component 13: Phenoxyethanol 0.4 parts. Component 14: Phenoxyethanol 0.162%, Dichlorobenzyl Alcohol 0.09%, Sodium Isostearyl Lactylate 0.03%, Ethylhexylglycerin 0.018%. Component 15: Sodium Benzoate 0.3%. Component 16: Guar Hydroxypropyltrimonium Chloride 0.255%, Water 0.03%, Sodium Chloride 0.015%. Component 17: Adenosine 0.25%. Component 18: Niacinamide 0.2%. Component 19: Allantoin 0.1275%, Creatine 0.0225%. Component 20: Panthenol 0.15%. Component 21: Taurine 0.13%. Component 22: Citric Acid 0.12%. Component 23: Angelica Cautilloba Root Extract 0.00376%, Butylene Glycol 0.04812%, Water 0.04812. Component 24: Sodium Lauroyl Oat Amino Acids 0.03%, Water 0.0685%, Phenoxyethanol 0.0009%, Ethylhexylglycerin 0.0001%, Tetrasodium EDTA 0.0005%. Component 25: Piroctone Olanthamine 0.1%. Component 26: Disodium EDTA 0.1%. Component 27: Hydroxydecanoic Acid 0.05%. Component 28: Ginsenosides 0.009%.

[0142] The anti-shedding composition comprises component 8 and component 5; and the preparation method of the anti-shedding composition is as follows:

[0143] 1. Mix cyclodextrin and maltodextrin with water respectively and heat to 40°C to fully dissolve; obtain 10 wt% aqueous solution of hydroxypropyl-β-cyclodextrin, 10 wt% aqueous solution of methyl-β-cyclodextrin and 5 wt% aqueous solution of maltodextrin respectively.

[0144] 2. Mix the Platycladus orientalis leaf extract and methyl-β-cyclodextrin aqueous solution in component 8 evenly, then add hydroxypropyl-β-cyclodextrin aqueous solution in sequence, stir and react for 1 to 2 hours, let stand and filter; add maltodextrin aqueous solution, and the mixture is ready.

[0145] The mass ratio of hydroxypropyl-β-cyclodextrin to methyl-β-cyclodextrin in the present invention is 3:1.

[0146] The preparation method of the Platycladus orientalis leaf extract is as follows:

[0147] (1) Crushing treatment: Take the dried Platycladus orientalis leaves and grind them into 30-60 mesh coarse powder;

[0148] (2) Preparation of pretreatment solution: 30% ethanol + 0.1% cellulase + 0.1% pectinase + pH 5.5 buffer

[0149] (3) The material-liquid ratio is 1:10. After adding the crude powder of Platycladus orientalis leaves, the mixture is heated at 45°C, stirred for 60 minutes, and then heated to 85°C for 10-15 minutes to inactivate the enzyme.

[0150] (4) Based on step (3), an equal volume of 60% ethanol (v / v) and 5% 1,2-pentanediol (w / v) were added, and the mixture was extracted in a 40°C water bath with magnetic stirring for 30 minutes;

[0151] (5) Then add 0.05% tocopherol acetate, 0.05% sodium ascorbate, and 0.05% EDTA-2Na, stir evenly, and place in a refrigerator at 4°C for 12 hours (to remove precipitates or floating matter); then use a rotary evaporator to reduce pressure and concentrate to about 1 / 3 of the volume at 45°C and 300 mbar.

[0152] The preparation steps of the shampoo are as follows:

[0153] S01 classifies the components of shampoo:

[0154] Phase A: 1 / 3 component 1, component 2, component 19, component 16, component 26, component 22, component 15

[0155] Phase B: component 3, component 4, component 7, component 17, component 18, component 21, component 27, 1 / 2 component 28

[0156] Phase C: component 5, component 6, component 9, component 10, component 14, component 20, component 23, component 24

[0157] Phase D: 1 / 3 component 1, component 8, remaining component 28

[0158] Phase E: Component 12, Component 13, Component 25

[0159] Phase F: Remaining component 1, component 11

[0160] S02: Add the materials of phase A into the main pot in sequence, heat and stir until the materials are completely dissolved. Control the temperature at 80-95℃, then add the materials of phase B into the pot in sequence, stir until completely dissolved, keep warm (75-80℃) and stir for 20 minutes;

[0161] S03 After the materials in the pot are completely dissolved, start stirring and cool to 45℃, add the C phase materials in sequence and stir evenly. Continue to cool to 40℃, disperse and dissolve the D phase evenly, add it to the pot and stir evenly, then add the E phase materials in sequence and stir evenly;

[0162] Add the evenly dispersed and dissolved F phase into S04 at 35℃ and stir evenly. Adjust to suitable viscosity and conduct sampling inspection. If qualified, the material can be discharged and stored.

[0163] Example 5

[0164] On one hand, this embodiment provides an anti-hair loss composition comprising: Thuja orientalis leaf extract, ginseng root extract, ethoxydiglycol, 1,2-pentanediol, PEG-40 hydrogenated castor oil and 1,2-hexanediol.

[0165] On the other hand, an anti-hair loss shampoo is provided, the raw materials for its preparation comprising:

[0166] Component 1: Water to 100 parts. Component 2: Sodium Laureth Sulfate 9.0 parts, Water 4.0 parts. Component 3: Water 5.24 parts, Cocamidopropyl Betaine 2.36 parts, Sodium Chloride 0.36 parts, Sodium Benzoate 0.04 parts. Component 4: Water 2.1 parts, Sodium Lauroyl Sarcosinate 0.89 parts, Sodium Lauroyl Glutamate 0.003 parts, Lauryl Diethylenediaminoglycine 0.003 parts. Component 5: Water 1.67 parts, Ethoxydiglycol 0.2 parts, Pentylene Glycol 0.05 parts, PEG-40 Hydrogenated Castor Oil 0.04 parts, 1,2-Hexanediol 0.02 parts, Panax Ginseng Root Extract 0.09 parts. Component 6: Dimethicone 0.84 parts, Water 0.2472 parts, Sodium Laureth Sulfate 0.1008 parts, Sodium Chloride 0.012 parts. Component 7: Cocamide MEA 0.95 parts, Methyl Cocoate 0.05 parts. Component 8: Thuja orientalis (Thuja orientalis) Leaf Extract 1.0 parts, Cyclodextrin 0.15 parts, Maltodextrin 0.15 parts, Ethoxydiglycol 0.02 parts, 1,2-Hexanediol 0.01 parts. Component 9: Water 0.5832 parts, Ammonium Lauryl Sulfate 0.08 parts, Hydrogenated Castor Oil 0.064 parts, Cocamide MEA 0.064 parts, Phenoxyethanol 0.0072 parts, Disodium EDTA 0.0008 parts, Sodium Benzoate 0.0008 parts. Component 10: Hydrolyzed Corn Starch 0.75 parts, Water 0.04 parts, Phenoxyethanol 0.006 parts. Component 11: Sodium Chloride 0.8 parts. Component 12: Fragrance (Daily Use) 0.5 parts. Component 13: Phenoxyethanol 0.4 parts. Component 14: Phenoxyethanol 0.162%, Dichlorobenzyl Alcohol 0.09%, Sodium Isostearyl Lactylate 0.03%, Ethylhexylglycerin 0.018%. Component 15: Sodium Benzoate 0.3%. Component 16: Guar Hydroxypropyltrimonium Chloride 0.255%, Water 0.03%, Sodium Chloride 0.015%. Component 17: Adenosine 0.25%. Component 18: Niacinamide 0.2%. Component 19: Allantoin 0.1275%, Creatine 0.0225%. Component 20: Panthenol 0.15%. Component 21: Taurine 0.13%. Component 22: Citric Acid 0.12%. Component 23: Angelica Cautilloba Root Extract 0.00376%, Butylene Glycol 0.04812%, Water 0.04812. Component 24: Sodium Lauroyl Oat Amino Acids 0.03%, Water 0.0685%, Phenoxyethanol 0.0009%, Ethylhexylglycerin 0.0001%, Tetrasodium EDTA 0.0005%. Component 25: Piroctone Olanthamine 0.1%. Component 26: Disodium EDTA 0.1%. Component 27: Hydroxydecanoic Acid 0.05%. Component 28: Ginsenosides 0.009%.

[0167] The anti-shedding composition comprises component 8 and component 5; and the preparation method of the anti-shedding composition is as follows:

[0168] 1. Mix cyclodextrin and maltodextrin with water respectively and heat to 40°C to fully dissolve; obtain hydroxypropyl-β-cyclodextrin aqueous solution (10 wt%), methyl-β-cyclodextrin aqueous solution (5 wt%) and maltodextrin aqueous solution (5 wt%) respectively.

[0169] 2. Mix the Platycladus orientalis leaf extract, ethoxydiglycol and 1,2-hexanediol in component 8; then add the methyl-β-cyclodextrin aqueous solution and stir evenly; then add the hydroxypropyl-β-cyclodextrin aqueous solution in turn and stir to react for 1 to 2 hours, let it stand and filter; add the maltodextrin aqueous solution and it is done.

[0170] The mass ratio of the hydroxypropyl-β-cyclodextrin to the methyl-β-cyclodextrin is 1:3.

[0171] The preparation method of the Platycladus orientalis leaf extract is as follows:

[0172] (1) Crushing treatment: Take the dried Platycladus orientalis leaves and grind them into 30-60 mesh coarse powder;

[0173] (2) Preparation of pretreatment solution: 30% ethanol + 0.1% cellulase + 0.1% pectinase + pH 5.5 buffer

[0174] (3) The material-liquid ratio is 1:10. After adding the crude powder of Platycladus orientalis leaves, the mixture is heated at 45°C, stirred for 60 minutes, and then heated to 85°C for 10-15 minutes to inactivate the enzyme.

[0175] (4) Based on step (3), an equal volume of 60% ethanol (v / v) and 5% 1,2-pentanediol (w / v) were added, and the mixture was extracted in a 40°C water bath with magnetic stirring for 30 minutes;

[0176] (5) Then add 0.05% tocopherol acetate, 0.05% sodium ascorbate, and 0.05% EDTA-2Na, stir evenly, and place in a refrigerator at 4°C for 12 hours (to remove precipitates or floating matter); then use a rotary evaporator to reduce pressure and concentrate to about 1 / 3 of the volume at 45°C and 300 mbar.

[0177] The preparation steps of the shampoo are as follows:

[0178] S01 classifies the components of shampoo:

[0179] Phase A: 1 / 3 component 1, component 2, component 19, component 16, component 26, component 22, component 15

[0180] Phase B: component 3, component 4, component 7, component 17, component 18, component 21, component 27, 1 / 2 component 28

[0181] Phase C: component 5, component 6, component 9, component 10, component 14, component 20, component 23, component 24

[0182] Phase D: 1 / 3 component 1, component 8, remaining component 28

[0183] Phase E: Component 12, Component 13, Component 25

[0184] Phase F: Remaining component 1, component 11

[0185] S02: Add the materials of phase A into the main pot in sequence, heat and stir until the materials are completely dissolved. Control the temperature at 80-95℃, then add the materials of phase B into the pot in sequence, stir until completely dissolved, keep warm (75-80℃) and stir for 20 minutes;

[0186] S03 After the materials in the pot are completely dissolved, start stirring and cool to 45℃, add the C phase materials in sequence and stir evenly. Continue to cool to 40℃, disperse and dissolve the D phase evenly, add it to the pot and stir evenly, then add the E phase materials in sequence and stir evenly;

[0187] Add the evenly dispersed and dissolved F phase into S04 at 35℃ and stir evenly. Adjust to suitable viscosity and conduct sampling inspection. If qualified, the material can be discharged and stored.

[0188] Example 6

[0189] On one hand, this embodiment provides an anti-hair loss composition comprising: Thuja orientalis leaf extract, ginseng root extract, ethoxydiglycol, 1,2-pentanediol, PEG-40 hydrogenated castor oil and 1,2-hexanediol.

[0190] On the other hand, an anti-hair loss shampoo is provided, the raw materials for its preparation comprising:

[0191] Component 1: Water to 100 parts. Component 2: Sodium lauryl sulfate 9.0 parts, water 4.0 parts. Component 3: Water 5.24 parts, lauramide DEA 2.36 parts, sodium chloride 0.36 parts, sodium benzoate 0.04 parts. Component 4: Water 2.1 parts, sodium myristate / soap surfactant 0.89 parts, AESA 0.003 parts, LAS 0.003 parts. Component 5: Water 1.67 parts, ethoxydiglycol 0.2 parts, 1,2-pentanediol 0.05 parts, PEG-40 hydrogenated castor oil 0.04 parts, 1,2-hexanediol 0.02 parts, Panax ginseng root extract 0.09 parts. Component 6: Dimethicone 0.84 parts, water 0.2472 parts, sodium laureth sulfate 0.1008 parts, sodium chloride 0.012 parts. Component 7: Cocamide MEA 0.95 parts, Methyl Cocoate 0.05 parts. Component 8: Thuja orientalis (Thuja orientalis) Leaf Extract 1.0 parts, Cyclodextrin 0.15 parts, Maltodextrin 0.15 parts, Ethoxydiglycol 0.02 parts, 1,2-Hexanediol 0.01 parts. Component 9: Water 0.5832 parts, Ammonium Lauryl Sulfate 0.08 parts, Hydrogenated Castor Oil 0.064 parts, Cocamide MEA 0.064 parts, Phenoxyethanol 0.0072 parts, Disodium EDTA 0.0008 parts, Sodium Benzoate 0.0008 parts. Component 10: Hydrolyzed Corn Starch 0.75 parts, Water 0.04 parts, Phenoxyethanol 0.006 parts. Component 11: Sodium Chloride 0.8 parts. Component 12: Fragrance (Daily Use) 0.5 parts. Component 13: Phenoxyethanol 0.4 parts. Component 14: Phenoxyethanol 0.162%, Dichlorobenzyl Alcohol 0.09%, Sodium Isostearyl Lactylate 0.03%, Ethylhexylglycerin 0.018%. Component 15: Sodium Benzoate 0.3%. Component 16: Guar Hydroxypropyltrimonium Chloride 0.255%, Water 0.03%, Sodium Chloride 0.015%. Component 17: Adenosine 0.25%. Component 18: Niacinamide 0.2%. Component 19: Allantoin 0.1275%, Creatine 0.0225%. Component 20: Panthenol 0.15%. Component 21: Taurine 0.13%. Component 22: Citric Acid 0.12%. Component 23: Angelica Cautilloba Root Extract 0.00376%, Butylene Glycol 0.04812%, Water 0.04812. Component 24: Sodium Lauroyl Oat Amino Acids 0.03%, Water 0.0685%, Phenoxyethanol 0.0009%, Ethylhexylglycerin 0.0001%, Tetrasodium EDTA 0.0005%. Component 25: Piroctone Olanthamine 0.1%. Component 26: Disodium EDTA 0.1%. Component 27: Hydroxydecanoic Acid 0.05%. Component 28: Ginsenosides 0.009%.

[0192] The anti-shedding composition comprises component 8 and component 5; and the preparation method of the anti-shedding composition is as follows:

[0193] 1. Mix cyclodextrin and maltodextrin with water respectively and heat to 40°C to fully dissolve; obtain hydroxypropyl-β-cyclodextrin aqueous solution (10 wt%), methyl-β-cyclodextrin aqueous solution (5 wt%) and maltodextrin aqueous solution (5 wt%) respectively.

[0194] 2. Mix the Platycladus orientalis leaf extract, ethoxydiglycol and 1,2-hexanediol in component 8; then add the methyl-β-cyclodextrin aqueous solution and stir evenly; then add the hydroxypropyl-β-cyclodextrin aqueous solution in turn and stir to react for 1 to 2 hours, let it stand and filter; add the maltodextrin aqueous solution and it is done.

[0195] The mass ratio of hydroxypropyl-β-cyclodextrin to methyl-β-cyclodextrin in the present invention is 1:3.

[0196] The preparation method of the Platycladus orientalis leaf extract is as follows:

[0197] (1) Crushing treatment: Take the dried Platycladus orientalis leaves and grind them into 30-60 mesh coarse powder;

[0198] (2) Preparation of pretreatment solution: 30% ethanol + 0.1% cellulase + 0.1% pectinase + pH 5.5 buffer

[0199] (3) The material-liquid ratio is 1:10. After adding the crude powder of Platycladus orientalis leaves, the mixture is heated at 45°C, stirred for 60 minutes, and then heated to 85°C for 10-15 minutes to inactivate the enzyme.

[0200] (4) Based on step (3), an equal volume of 60% ethanol (v / v) and 5% 1,2-pentanediol (w / v) were added, and the mixture was extracted in a 40°C water bath with magnetic stirring for 30 minutes;

[0201] (5) Then add 0.05% tocopherol acetate, 0.05% sodium ascorbate, and 0.05% EDTA-2Na, stir evenly, and place in a refrigerator at 4°C for 12 hours (to remove precipitates or floating matter); then use a rotary evaporator to reduce pressure and concentrate to about 1 / 3 of the volume at 45°C and 300 mbar.

[0202] The preparation steps of the shampoo are as follows:

[0203] S01 classifies the components of shampoo:

[0204] Phase A: 1 / 3 component 1, component 2, component 19, component 16, component 26, component 22, component 15

[0205] Phase B: component 3, component 4, component 7, component 17, component 18, component 21, component 27, 1 / 2 component 28

[0206] Phase C: component 5, component 6, component 9, component 10, component 14, component 20, component 23, component 24

[0207] Phase D: 1 / 3 component 1, component 8, remaining component 28

[0208] Phase E: Component 12, Component 13, Component 25

[0209] Phase F: Remaining component 1, component 11

[0210] S02: Add the materials of phase A into the main pot in sequence, heat and stir until the materials are completely dissolved. Control the temperature at 80-95℃, then add the materials of phase B into the pot in sequence, stir until completely dissolved, keep warm (75-80℃) and stir for 20 minutes;

[0211] S03 After the materials in the pot are completely dissolved, start stirring and cool to 45℃, add the C phase materials in sequence and stir evenly. Continue to cool to 40℃, disperse and dissolve the D phase evenly, add it to the pot and stir evenly, then add the E phase materials in sequence and stir evenly;

[0212] Add the evenly dispersed and dissolved F phase into S04 at 35℃ and stir evenly. Adjust to suitable viscosity and conduct sampling inspection. If qualified, the material can be discharged and stored.

[0213] Performance Testing

[0214] Test 1: Encapsulation efficiency test

[0215] Test steps:

[0216] Step "1. Mix cyclodextrin and maltodextrin with water respectively, and heat to 40°C to fully dissolve; obtain hydroxypropyl-β-cyclodextrin aqueous solution, methyl-β-cyclodextrin aqueous solution and maltodextrin aqueous solution respectively.

[0217] 2. Mix the Platycladus orientalis leaf extract, ethoxydiglycol, and 1,2-hexanediol in component 8; then add the methyl-β-cyclodextrin aqueous solution and stir evenly. Then, add the hydroxypropyl-β-cyclodextrin aqueous solution and stir for 1-2 hours. After standing and filtering, add the maltodextrin aqueous solution. The resulting product is designated as a complex, and the encapsulation efficiency of the complex is determined by testing Examples 2-5.

[0218] Sample preparation: Take a certain amount of complex (approximately 100 mg) and add 20 mL of ice-cold deionized water. After gentle vortexing, collect the supernatant. Control preparation: Completely dissolve the same amount of unencapsulated Platycladus orientalis leaf extract as the reference solution. The supernatant contains the free, unencapsulated components. Determine the active ingredient content by HPLC. EE (%) = (1 - free active ingredient / total added active ingredient) * 100%.

[0219] Table 1 Test results of test 1

[0220] Example Encapsulation efficiency Example 2 71.4％ Example 3 75.3％ Example 4 76.1％ Example 5 82.5％

[0221] Test 2: Stability test

[0222] The shampoos obtained in Examples 1 to 6 were subjected to a thermal stability test to check the product shape.

[0223] The products were placed at 0°C, 25°C and 40°C for 90 days, and their properties and color were checked. The test results are shown in Table 2.

[0224] Hot and cold cycle test: Place the shampoo prepared in Examples 1-6 into a sealed container, ensuring it is completely sealed to prevent interference from external humidity or gas. Place the sample in a thermostat set at 45°C for 12 hours. After removing the sample, quickly transfer it to a low-temperature box at -5°C and hold it for 12 hours. After completing one high and low temperature cycle, repeat six times; after each cycle, inspect the sample's appearance, color, odor, viscosity, stratification, and other physical properties.

[0225] Table 2 Test results of test 2

[0226] Example 0℃ 25℃ 40℃ Hot and cold cycle test Example 1 No change No change Color Change Color Change Example 2 No change No change Color Change Color Change Example 3 No change No change Slight delamination Slight delamination Example 4 No change No change No change No change Example 5 No change No change No change No change Example 6 No change No change Slight delamination Slight delamination

[0227] Test 3: Test method for the efficacy of cosmetics in preventing hair loss

[0228] 1. Test products: Examples 1 to 6

[0229] 2. Control product: A product formulated with the corresponding test product matrix but without the anti-hair loss ingredients, tested in parallel with the test product.

[0230] 3. Wash-out products: Same as the control products. Both the experimental group and the control group use the control products during the wash-out period.

[0231] 4. Subjects: A total of 66 valid subjects completed the test. The planned number of subjects in the experimental group was 33, and the actual number of valid subjects was 33. The planned number of subjects in the control group was 33, and the actual number of valid subjects was 33. There were 61 males and 5 females, aged 19 to 55 years old, who met the voluntary selection criteria for subjects.

[0232] 5. Test equipment: Professional digital camera: Pixels must be no less than 15 million. Parameters such as aperture, ISO, and focal length must remain consistent throughout the test. Image capture stand: Capable of fixing the subject's head position so that the top of the head is perpendicular to the camera lens. Used in conjunction with a professional digital camera to capture images of the entire hair centered on the top of the head. Dermatoscope: LED light source, wavelength 450-750nm, color temperature 6500-8000K, illumination no less than 540lx, magnification >20x, detection diameter no less than 1.0cm or area no less than 0.8cm. Comb: Moderate tooth density (tooth spacing 0.9-1.1mm), tooth length 2.0-3.0cm, and comb length no less than 10cm (excluding the comb handle). Combs of the same specifications and material must be used throughout the test. Disinfection must be performed after each use in accordance with the relevant requirements of the "Technical Specifications for Disinfection of Medical Institutions" (WS-T367-2012).

[0233] 6. Test method: The test was conducted in accordance with the specific requirements of the "Technical Specifications for Safety of Cosmetics" (2015 edition). Volunteer subjects were recruited according to the inclusion and exclusion criteria, and the hair loss was counted using the 60-combing method and recorded. Qualified subjects underwent a 2-week washout period, and after the washout period, they were again subjected to the 60-combing method. Only those with a hair loss count of more than 10 hairs could enter the formal trial. The subjects were divided into the test product group and the control product group according to the stratified random method. The subjects' hair baseline values before the test product were assessed, including hair loss counts, hair density assessments, and image capture, and the results were recorded. The product was used continuously for 12 weeks according to the product instructions, and the same evaluation and testing were performed again 12 weeks after the product was used.

[0234] Table 3 Significance analysis before and after product use

[0235]

[0236] Note: "NS" means P ≥ 0.05, no significant difference; "S" means P < 0.05, there is a significant difference.

[0237] Test 4: Results of acute eye irritation test of the test substance to domestic animals

[0238] 1. Test substance: Example 5, directly used as the test substance.

[0239] 2. Experimental animals and breeding environment:

[0240] Experimental animals: 3 New Zealand rabbits (ordinary grade, male, body weight 2.0 - 2.5 kg), animal certificate number: NO.44411600015890. Animal source: Purchased from Guangdong Medical Experimental Animal Center (Sanshui Base), experimental animal production license number: SCXK(Yue)2023 - 0035. Feeding environment: Ordinary environment, temperature 21.8 - 23.6 °C, relative humidity 62.3 - 65.6 RH%, experimental animal environment use license number: SYXK(Yue)2023 - 0216.

[0241] Feed: Provided by Jiangquan Feed Factory of Linyi Shengquan Oil & Chemical Co., Ltd., license number: Lu Sizheng(2024)16062, quality certificate number: NO.2024071600177.

[0242] Within 24 hours before the test, the two eyes of the above animals were examined (including using sodium fluorescein), and no eye irritation symptoms were found.

[0243] 3. Test method: Take 3 of the above animals, gently pull down the lower eyelid of the right eye of the rabbit, and drop 100 mg of the test substance into the conjunctival sac, making the upper and lower eyelids close passively for 1 s. At the 30th second, rinse with water at a sufficient flow rate that does not cause eye injury to the animal for 30 s. The left eye is not treated as a self-control. At the 1st hour, 24th hour, 48th hour, 72nd hour, 4th day, and 7th day after dropping the test substance, the eyes of the animals were examined using a magnifying glass and a pupil pen light. At the same time, after the 24-hour observation and recording, during each examination, the eyes of all animals were examined with sodium fluorescein. The eye irritation reaction was scored according to Table 1 in Part 5 of Chapter 6 of the "Technical Specifications for Cosmetics Safety" (2015 Edition). If no irritation reaction is found within 72 hours, the test can be terminated. If corneal involvement or other eye irritation effects are found and do not recover within 7 days, the observation time needs to be extended to 21 days, and observation reports for 7 days, 14 days, and 21 days should be provided.

[0244] Table 4 Results of Acute Eye Irritation Test of the Test Substance on Rabbits

[0245]

[0246] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements for some or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. An anti-shedding composition, characterized in that The anti-hair loss composition comprises: Platycladus orientalis leaf extract, cyclodextrin and maltodextrin.

2. The anti-shedding composition according to claim 1, wherein The cyclodextrin is a mixture of hydroxypropyl-β-cyclodextrin and methyl-β-cyclodextrin.

3. The anti-shedding composition according to claim 1, wherein The anti-shedding composition further comprises ethoxydiglycol and 1,2-hexanediol.

4. The anti-shedding composition according to claim 1, wherein The anti-hair loss composition further comprises ginseng root extract, ethoxydiglycol, 1,2-pentanediol, PEG-40 hydrogenated castor oil and 1,2-hexanediol.

5. The anti-shedding composition according to any one of claims 1 to 4, characterized in that The anti-hair loss composition is applied in the field of daily chemicals.

6. An anti-hair loss shampoo, characterized in that: The invention comprises the anti-shedding composition according to any one of claims 1 to 4.

7. The anti-hair loss shampoo according to claim 6, characterized in that: The raw materials for preparing the hair care product include: a solvent, a surfactant, a hair conditioner, a moisturizer, a chelating agent, an anti-dandruff agent, and the anti-hair loss composition according to any one of claims 1 to 4.

8. The anti-hair loss shampoo according to claim 7, characterized in that: The hair conditioning agent includes sodium laureth sulfate, hydrolyzed corn starch, guar hydroxypropyltrimonium chloride, allantoin, creatine, angelica root extract, sodium lauroyl oat amino acids, and hydroxydecanoic acid.

9. The anti-hair loss shampoo according to claim 7, characterized in that: The surfactant comprises sodium lauroyl sarcosinate, sodium lauroyl glutamate, lauryl diethylenediaminoglycine, sodium laureth sulfate, and ammonium lauryl sulfate.

10. The anti-hair loss shampoo according to claim 7, characterized in that: The pH value of the shampoo is 5.5 to 6.2.

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