Cold compress cover, essence and preparation process of essence

Abstract

The invention discloses a cold compress cover, essence and a production process thereof, the cold compress cover is prepared by the following steps: firstly weighing carbamide and high-molecular water-absorbent resin according to a formula proportion, sieving the carbamide with a sieve, putting the carbamide into a mixer, then adding the high-molecular water-absorbent resin, mixing and stirring to prepare a cold compress inner material, forming, spraying glue, punching, folding and bagging, and sealing to obtain the cold compress cover. The preparation method comprises the following steps: weighing wild chrysanthemum flower, red sage root and phellodendron according to a mass part ratio, carrying out decoction extraction filtration, vacuum reduced pressure concentration, tubular separation and refrigeration on the three directly collected traditional Chinese medicinal materials to obtain a traditional Chinese medicinal material extract, preparing an essence, and mixing the traditional Chinese medicinal material extract, an auxiliary material and a multi-element carrier penetration enhancer according to a mass ratio to prepare the essence. And finally, filling, sealing and irradiating the essence, and finally packaging the essence and a cold compress cover together. The prepared cold compress cover and essence combination can relieve eye fatigue and treat and slow down the myopia problem, safety is high, and no adverse reaction exists.

Description

Technical Field

[0001] The invention relates to the technical field of eye patches, in particular to a cold compress mask, essence and a preparation process thereof. Background Art

[0002] As various electronic products become a necessity in our lives, our eyes have less and less time to rest. Staring at electronic screens for long periods of time can easily cause dry eyes, eye fatigue, and a series of problems such as myopia. In addition to adjusting your daily routine, medication-assisted treatment is also a very important method to alleviate myopia.

[0003] Patent CN112472743A discloses a new medical material eye cold therapy dressing and its preparation method. First, angelica extract, coptis extract, phellodendron extract, salvia miltiorrhiza extract, wild chrysanthemum extract, and cassia seed extract are dissolved in purified water. Then, glycerol, propylene glycol, tea tree oil, menthol, borneol, and plant essential oils are added to the purified water to form a cold compress gel. Finally, the dressing is applied on non-woven fabric to make a cold therapy dressing. The cooling method of the dressing is refrigeration physical cooling, which is inconvenient to carry and has poor portability. At the same time, the added extracts are not strictly matched according to the compatibility theory of traditional Chinese medicine, but are added in small amounts at random. They cannot fully exert their efficacy in relieving eye fatigue, myopia and other problems, and the actual treatment effect is greatly reduced. Summary of the Invention

[0004] The purpose of the present invention is to overcome the shortcomings of the prior art and provide a cold compress mask, essence and preparation process thereof to solve the problem that the traditional Chinese medicine cold compresses in the prior art cannot effectively and reasonably treat problems such as eye fatigue and myopia.

[0005] The purpose of the present invention is achieved through the following technical solution: a cold compress mask, which comprises 600-650 parts by mass of carbonamide and 15-80 parts by mass of a high molecular water-absorbing resin.

[0006] A serum consists of the following components, calculated by weight: 10 parts of wild chrysanthemum, 6 parts of salvia miltiorrhiza, 8 parts of phellodendron amurense, 1 part of Xanthoceras serrata fruit extract, 3 parts of pearl powder, 1 part of stearyl dimethyl ammonium hydroxypropyl hydrolyzed silk protein, 1 part of xanthan gum, 0.2 parts of sodium hyaluronate, 1 part of glycerin, 3 parts of p-hydroxyacetophenone, 9 parts of propylene glycol, 2 parts of glyceryl caprylate, 0.05 parts of caprylhydroxamic acid, 20 parts of a penetration enhancer, and 1000 parts of water.

[0007] Preferably, the penetration enhancer is composed of d-borneol, menthol, 95% ethanol, cyclodextrin, and water, and the mass ratio of d-borneol, menthol, 95% ethanol, cyclodextrin, and water is 1:3-5:1.5-2:20-25:200-300.

[0008] A production process for a cold compress mask and an essence liquid is prepared according to the following steps: S1: preparing a cold compress cover, weighing carbonamide and a high molecular weight water-absorbing resin according to a formula ratio, screening the carbonamide and adding it into a mixer, then adding the high molecular weight water-absorbing resin and mixing and stirring to form a cold compress inner material, and then forming, spraying glue, punching, folding, bagging, and sealing the cold compress cover; S2 preparation of Chinese herbal medicine extract, according to the mass ratio weighed wild chrysanthemum, salvia miltiorrhiza, phellodendron, the three direct-collecting Chinese herbal medicines by decoction extraction filtration, vacuum concentration, tubular separation, refrigeration to obtain Chinese herbal medicine extract; S3. Prepare the essence by mixing the herbal extract, excipients, and multi-carrier penetration enhancers in a mass ratio to form an essence; S4. The essence is filled, sealed, irradiated, and finally packaged together with the cold compress mask.

[0009] Preferably, in step S1, carbonamide is passed through a 40-45 mesh sieve, and carbonamide and the polymer water-absorbing resin are mixed and stirred for 30-40 minutes.

[0010] Preferably, in step S2, the boiling temperature is 100°C, the refrigeration temperature is -3°C to 4°C, and the refrigeration time is more than 24 hours.

[0011] Preferably, in step S2, a double-effect reduced pressure concentration process is used, the steam pressure of the effect I heater is controlled at ≤0.2 MPa, the heating temperature is controlled at 70°C to 80°C, the vacuum degree is controlled at -0.04 MPa to -0.06 MPa, and the temperature of the effect II concentrator is controlled at 60°C to 70°C, and the vacuum degree is controlled at -0.06 MPa to -0.07 MPa.

[0012] Preferably, in step S2, the three Chinese herbal extracts are mixed and decocted, with a density of 1.0-2.0, and the amount of paste collected is 65kg±10kg / time.

[0013] The present invention has the following advantages: 1. A production process for cold compress masks and serums is provided. The cold compress mask production process uses carbonamide and a high-molecular-weight water-absorbing resin as the cold compress inner material. Simply mixing the serum with the cold compress mask quickly achieves heat absorption and cooling. Compared to gel-based refrigeration cooling methods, this improves convenience during use. The highly absorbent resin's water-locking properties also extend the duration of the cooling effect. 2. Wild chrysanthemum has the effects of clearing the liver and improving eyesight and has anti-inflammatory and antioxidant effects. The flavonoids and phenolic acid components in wild chrysanthemum can block the release of inflammatory mediators, relieve the inflammatory congestion of ciliary muscles and periocular tissues, and the polyphenol components it contains can scavenge free radicals and reduce the damage of oxidative stress to retinal cells. In clinical applications, it is often used in combination with wolfberry and cassia seed to enhance the eye protection effect; Salvia miltiorrhiza has the function of promoting blood circulation and removing blood stasis and regulating the hypoxia mechanism. Its blood circulation effect is often coordinated with Angelica sinensis and Astragalus membranaceus in Yijing Mingmu Decoction to enhance the effect of qi and blood on the eyes; Phellodendron chinense has the effects of nourishing yin and reducing fire and antibacterial regulation. Phellodendron chinense can reduce the deficiency fire of liver meridian. When used with Anemarrhena asphodeloides and Rehmannia glutinosa, it can relieve the blurred vision caused by yin deficiency and fire. Wild chrysanthemum, Salvia miltiorrhiza and Phellodendron chinense are three Chinese medicinal materials used in traditional Chinese medicine. The commonly used medicines in the prescription are used in combination with other Chinese medicinal materials to achieve different therapeutic effects. In particular, in the Chinese medicine prescriptions related to the treatment and relief of myopia, they are often separated and combined with different Chinese medicinal materials to make decoctions or pastes for direct use. The present invention uses them as extracts through decoction method, strictly controls the extraction conditions, and only uses the three in coordination without the need for other Chinese medicinal components. The other components are optimized and formulated to work together to form an essence product. The essence product has been verified by three tests: the evaluation test for relieving visual fatigue, the test for intervening in form deprivation myopia model guinea pigs, and the test for relieving video terminal visual fatigue. It is proved that it has outstanding advantages and contributions in relieving eye fatigue and treating and slowing myopia. At the same time, the product is highly safe for human skin and has no adverse reactions.

[0014] 3. The production process, cold compress mask, and essence products provided by the present invention optimize the process and ratio conditions. Compared with the publicly available cold compress patches made of Chinese herbal medicine extracts, their authenticity and reliability have been verified through multiple tests and are worthy of trust and use. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a preparation process flow chart of the present invention; Figure 2 This is a photograph of a guinea pig HE-stained section of the present invention; Figure 3 This is a comparative test diagram of alleviating visual fatigue of video terminals according to the present invention. DETAILED DESCRIPTION

[0016] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention.

[0017] A cold compress mask and essence are prepared according to the following process steps: S1: preparing a cold compress cover, weighing carbonamide and a high molecular weight water-absorbing resin according to a formula ratio, passing the carbonamide through a 40-45 mesh sieve and placing it into a mixer, then adding the high molecular weight water-absorbing resin and mixing and stirring for 30-40 minutes to form a cold compress inner material, and then forming the cold compress inner material. In the forming process, a spunlace non-woven fabric is used for the water-permeable layer and a common non-woven fabric is used for the waterproof layer. Then, the cold compress cover is sprayed with glue, punched, folded, bagged, and sealed to obtain the cold compress cover. S2. Preparation of Chinese herbal medicine extracts, weighing wild chrysanthemum, salvia miltiorrhiza, and phellodendron according to the mass ratio, and then the three kinds of Chinese herbal medicines were directly mined through 10 times the water temperature control 100 ℃, 5 hours of mixed decoction extraction filtration, using a double-effect vacuum concentration process, Ⅰ effect heater steam pressure was controlled at ≤0.2MPa, the heating temperature was controlled at 70 ℃ ~ 80 ℃, the vacuum degree was controlled at -0.04MPa ~ -0.06MPa, Ⅱ effect concentrator temperature was controlled at 60 ℃ ~ 70 ℃, the vacuum degree was controlled at -0.06MPa ~ -0.07MPa, mixed decoction to obtain a mixed extract with a density of 1.0-2.0, the amount of the paste was collected by 65kg ± 10kg / time, and then 2.5 ± 0.5kg / min tubular separation, refrigeration time was 24h to obtain Chinese herbal medicine extracts; S3. Prepare the essence by mixing the herbal extract, excipients, and multi-carrier penetration enhancers in a mass ratio to form an essence; S4. Fill the essence into bags, 15.0g ± 0.5g per bag, seal the bags, irradiate with 8KGy, and finally package them together with the cold compress.

[0018] Example 1 The eye cold compress and essence prepared according to the above method are composed of the following components, measured by mass in grams,: 630g of carbonamide, 40g of high molecular water-absorbing resin, 10g of wild chrysanthemum, 6g of salvia miltiorrhiza, 8g of phellodendron, 1g of Xanthoceras serrata fruit extract, 3g of pearl powder, 1g of stearyl dimethyl ammonium hydroxypropyl hydrolyzed silk protein, 1g of xanthan gum, 0.2g of sodium hyaluronate, 1g of glycerin, 3g of parahydroxyacetophenone, 9g of propylene glycol, 2g of glyceryl caprylate, 0.05g of caprylhydroxamic acid, 0.09g of dextrorotatory borneol, 0.35g of menthol, 0.15g of 95% ethanol, 2g of cyclodextrin, and 1017.41g of water.

[0019] Example 2 The eye cold compress and essence prepared according to the above method are composed of the following components, measured by mass in grams,: 600g of carbonamide, 15g of high molecular water-absorbing resin, 10g of wild chrysanthemum, 6g of salvia miltiorrhiza, 8g of phellodendron, 1g of Xanthoceras serrata fruit extract, 3g of pearl powder, 1g of stearyl dimethyl ammonium hydroxypropyl hydrolyzed silk protein, 1g of xanthan gum, 0.2g of sodium hyaluronate, 1g of glycerin, 3g of parahydroxyacetophenone, 9g of propylene glycol, 2g of glyceryl caprylate, 0.05g of caprylhydroxamic acid, 0.09g of dextrorotatory borneol, 0.27g of menthol, 0.20g of 95% ethanol, 2.5g of cyclodextrin, and 1016.94g of water.

[0020] Example 3 The eye cold compress and essence prepared according to the above method are composed of the following components, measured by mass in grams,: 650g of carbonamide, 80g of high molecular water-absorbing resin, 10g of wild chrysanthemum, 6g of salvia miltiorrhiza, 8g of phellodendron, 1g of Xanthoceras serrata fruit extract, 3g of pearl powder, 1g of stearyl dimethyl ammonium hydroxypropyl hydrolyzed silk protein, 1g of xanthan gum, 0.2g of sodium hyaluronate, 1g of glycerin, 3g of parahydroxyacetophenone, 9g of propylene glycol, 2g of glyceryl caprylate, 0.05g of caprylhydroxamic acid, 0.09g of dextrorotatory borneol, 0.45g of menthol, 0.20g of 95% ethanol, 2.5g of cyclodextrin, and 1016.76g of water.

[0021] The product obtained by using the ratio data of Example 1 was used to conduct an evaluation test on alleviating visual fatigue. The test was conducted by a third-party testing laboratory, Specimen Testing, with a total of 13 subjects, including 12 males and 18 females, aged 22 to 59 years old, with an average age of 31.70±9.89 years old. They met the voluntary inclusion criteria. The test design used before-and-after controls within the subjects themselves, and a randomized, double-blind approach was used to reduce or control bias. A questionnaire survey was used to collect feedback on product usage from the subjects.

[0022] The following are the evaluations of the test products after 14 days of use by the subjects: Evaluation indicators D14 1. Evaluation of relief of dry eye symptoms after using the product for a period of time 100.00% 2. Evaluation of relief of itchy eyes after using the product for a period of time 76.67% 3. Evaluation of the relief of photophobia symptoms after using the product for a period of time 80.00% 4. Evaluation of relief of tearing symptoms after using the product for a period of time 80.00% 5. Evaluation of relief of eye soreness and swelling symptoms after using the product for a period of time 100.00% 6. Evaluation of relief of eye stinging symptoms after using the product for a period of time 93.33% 7. Evaluation of the relief of blurred vision symptoms after using the product for a period of time 83.33% 8. Evaluation of the relief of blinking symptoms after using the product for a period of time 90.00% 9. Evaluation of the relief of eye rubbing symptoms after using the product for a period of time 96.67% 10. Evaluation of the relief of vision loss symptoms after using the product for a period of time 70.00% 11. Overall satisfaction evaluation after using the product for a period of time 100.00% "Evaluation indicators: 1 is 'very dissatisfied', 2 is 'unsatisfied', 3 is 'average', 4 is 'satisfied', and 5 is 'very satisfied'. Count the percentage of people with a score of N ≥ 4. 'N' represents the number of people using the product = 30." Results: This product can relieve symptoms of visual fatigue such as dry eyes, itching, photophobia, tearing, soreness, stinging, blurred vision, blinking, and rubbing eyes.

[0023] The safety of the samples on human skin was observed through human trial experiments. The results are shown in the following table Skin reactions Grading Day 0 Day 14 No response 0 30 cases 30 cases Faint erythema 1 0 cases 0 cases Erythema, infiltration, papules 2 0 cases 0 cases Erythema, edema, papules, blisters 3 0 cases 0 cases Erythema, edema, bullae 4 0 cases 0 cases Results: No adverse events occurred during this test.

[0024] Study on the effect of this product on the form deprivation myopia model guinea pigs The study, commissioned by the School of Pharmacy at Henan University of Traditional Chinese Medicine, involved 84 guinea pigs randomly divided into seven groups, each consisting of 12 animals, half male and half female. Except for the normal control (NC) group, the other six groups were induced into a form deprivation myopia (FDM) model. These six groups included the model group, the positive control steam eye patch group, the preventive cold compress eye patch groups with high and low doses, and the therapeutic cold compress eye patch groups with high and low doses. The NC group received no intervention. In all modeling groups, the right eye served as the deprived eye. A special headgear with a size 6 milky white balloon support was placed on the guinea pigs' heads, leaving the nose, mouth, left eye, and ear exposed. The headgear was checked daily to ensure complete coverage of the right eye. The headgear was covered 24 hours a day for 30 consecutive days.

[0025] In the positive control group, the steam eye patch group, applied the eye patch externally on the first day of modeling. The moisturizing patch and the moisturizing patch were applied to the right eye of the mouse, once a day for 15 minutes, and continued for 4 weeks. In the cold compress eye patch prevention high- and low-dose groups, the eye patch was applied externally on the first day of modeling. The liquid in the cold compress eye patch was poured onto the cold compress mask, which was cooled, and then the eye patch was applied to the right eye of the guinea pig. The high-dose group applied the eye patch twice a day for 15 minutes, and the low-dose group applied the eye patch once a day for 15 minutes, and continued for 4 weeks. In the cold compress eye patch treatment group, the high- and low-dose groups applied the eye patch externally 4 weeks after modeling. The liquid in the cold compress eye patch was poured onto the eye mask, which was cooled, and then the eye patch was applied to the right eye of the guinea pig. The high-dose group applied the eye patch twice a day for 15 minutes, and continued for 4 weeks.

[0026] Pathological observation by HE staining Guinea pigs were anesthetized with an intraperitoneal injection of sodium pentobarbital (0.2 mg / ml) and then rapidly sacrificed. The right eyeball was quickly removed and fixed in fixative for 24 hours. The cornea, lens, and other anterior segments of the eye were then removed. The vitreous humor was gently removed, and the sclera and optic nerve were removed within a 6-mm diameter area centered on the optic nerve. The ocular tissue was then excised using conventional gradient dehydration, embedded in wax, and stained with hematoxylin and eosin for pathological observation.

[0027] Slice photos such as Figure 2 The results are shown in the following table Group - + ++ +++ P Normal control (NC group) 12 0 0 0 * Model Group 0 0 2 10 - Positive control steam eye patch group 1 7 3 1 ** Cold compress eye patch prevents high-dose group 1 6 3 2 ** Cold compress eye patch for prevention of low-dose group 0 5 5 2 * Cold compress eye patch treatment of high-dose group 0 3 6 3 Cold compress eye patch treatment low dose group 0 2 5 5 Note: In the figure, A is the normal control (NC) group; B is the model group; C is the positive control steam eye patch group; D is the high-dose cold compress eye patch prevention group; E is the low-dose cold compress eye patch prevention group; F is the high-dose cold compress eye patch treatment group; G is the low-dose cold compress eye patch treatment group. Compared with the model group, *P<0.05, **P<0.01. "-" indicates normal, tightly packed and orderly arrangement of ciliary muscle fibers; "+" indicates partially disordered ciliary muscle fiber arrangement with signs of looseness; "++" indicates loose, irregularly arranged ciliary muscle fibers with moderate looseness; "+++" indicates disordered ciliary muscle fiber arrangement with loose fibers and dissolution and rupture.

[0028] Results: In the normal control (NC) group, the ciliary muscle fibers of guinea pigs were arranged evenly, tightly and orderly, without atrophy or breakage; in the model group, the ciliary muscle fibers of guinea pigs were arranged loosely and chaotically, with atrophy, dissolution and breakage; in the high-dose cold compress eye patch prevention group and the positive control steam eye patch group, the ciliary muscle fibers of guinea pigs were arranged in an obvious orderly manner and relatively intact, without obvious dissolution, breakage and fiber atrophy; in the low-dose cold compress eye patch prevention group, there were slight dissolution, breakage and fiber atrophy; in the cold compress eye patch treatment group, there were slight fiber disorder and atrophy, but there was an overall improvement trend.

[0029] ELISA detection: protein expression of MMP-3, TIMP-3 and Col3α1 in ciliary muscle of guinea pigs in each group After the guinea pigs were killed, the ciliary muscle tissue of the model eye was separated and RIPA buffer containing phenylmethylsulfonyl fluoride (PMSF) was added according to the mass volume ratio (10 mg:100 μL). The tissue was fully ground by electric homogenization and then lysed at 5000 r·min -1 Centrifuge for 5 minutes, take the supernatant and perform ultrasonic crushing at 5000 r·min -1 After centrifugation for 5 minutes, the supernatant was collected and the total protein concentration in the ciliary muscle tissue solution of each group of guinea pigs was determined using a BCA protein concentration assay kit (enhanced). The relative expression levels of MMP-3, TIMP-3 and Col3α1 proteins were detected using ELISA kits.

[0030] The results are as follows Group MMP-3 (ng / ml) TIMP-3 (pg / ml) Col3al (ng / ml) Normal control (NC group) 10.69±0.63** 1260.47±71.22** 37.32±3.99** Model Group 8.55±1.52 1108.94±49.23 29.72±1.69 Positive control steam eye patch group 12.55±0.75** 1487.22±213.09** 42.24±6.9** Cold compress eye patch prevents high-dose group 11.15±1.24** 1393.73±105.69** 41.85±4.86** Cold compress eye patch for prevention of low-dose group 41.85±4.86** 1252.95±78.38* 39.21±7.81** Cold compress eye patch treatment of high-dose group 8.65±0.64 1219.63±118.17 32.32±2.77* Cold compress eye patch treatment low dose group 8.30±0.4 1171.27±94.89 31.39±2.71 Note: Compared with the model group, *P<0.05, **P<0.01 Results: As can be seen from the table above, compared with the normal control (NC) group, the expression levels of MMP-3, TIMP-3 and Col3α1 proteins in the ciliary muscle of guinea pigs in the model group were significantly decreased (P<0.01); compared with the model group, the cold compress eye patch high-dose group and the positive control steam eye patch group could significantly increase the expression levels of MMP-3, TIMP-3 and Col3α1 proteins in the ciliary muscle of guinea pigs (P<0.01); the cold compress eye patch low-dose group could significantly increase The expression of TIMP-3 protein in the ciliary muscle of guinea pigs was increased, and the expression of Col3α1 protein was significantly increased (P<0.01), with a trend of increasing the expression of MMP-3 protein (P>0.05); the high-dose group treated with cold compress eye patch could significantly increase the expression of Col3al protein in the ciliary muscle of guinea pigs ((P<0.05)); the high-dose and low-dose groups treated with cold compress eye patch had a trend of increasing the expression of MMP-3 and TIMP-3 proteins in the ciliary muscle of guinea pigs (P>0.05).

[0031] Conclusion: In the early stages of myopia development, this product can intervene and affect the expression of MMP-3, TIMP-3 and Col3α1 in the ciliary muscle, and significantly delay the occurrence and development of myopia.

[0032] Experiment on Relieving Visual Fatigue of Video Terminals This trial employed a single-center, randomized, double-blind, placebo-controlled clinical trial design. A total of 94 participants (including dropouts) were enrolled in a 1:1 experimental group:control group ratio. Participants experiencing visual fatigue induced by viewing a video terminal underwent visual acuity and optometry tests, as well as relative accommodation, accommodation sensitivity, accommodation response, TBUT, and conjunctival hyperemia. Afterwards, participants viewed their mobile phone in a dark room for one hour. Finally, visual acuity and optometry tests, as well as relative accommodation, accommodation sensitivity, accommodation response, TBUT, and conjunctival hyperemia tests, were performed. The experimental group used a cold compress eye patch, while the control group used a control eye patch.

[0033] The test results are as follows Figure 3 shown.

[0034] Results: Statistical indicators for the control and experimental groups before and after viewing the VDT and after using the eye patch are labeled with letters; $ indicates a significant difference between the control and experimental groups at that time point (P < 0.05). The eye patch in the experimental group increased PRA, improved monocular and binocular accommodation sensitivity, prolonged TBUT, and improved conjunctival congestion. However, the experimental group was significantly superior to the control group only in terms of prolonged TBUT (P < 0.05).

[0035] Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A cold compress mask, characterized in that: Calculated by weight, the invention comprises 600-650 parts of carbonamide and 15-80 parts of high molecular water-absorbing resin.

2. An essence, characterized in that: The invention is composed of the following components in parts by mass: 10 parts of wild chrysanthemum, 6 parts of salvia miltiorrhiza, 8 parts of phellodendron amurense, 1 part of Xanthoceras serrata fruit extract, 3 parts of pearl powder, 1 part of stearyl dimethyl ammonium hydroxypropyl hydrolyzed silk protein, 1 part of xanthan gum, 0.2 parts of sodium hyaluronate, 1 part of glycerin, 3 parts of p-hydroxyacetophenone, 9 parts of propylene glycol, 2 parts of glyceryl caprylate, 0.05 parts of caprylhydroxamic acid, 20 parts of penetration enhancer, and 1000 parts of water.

3. The essence according to claim 4, characterized in that: Calculated by weight, the penetration enhancer consists of d-borneol, menthol, 95% ethanol, cyclodextrin and water, and the mass ratio of d-borneol, menthol, 95% ethanol, cyclodextrin and water is 1:3-5:1.5-2:20-25:200-300.

4. A production process for a cold compress mask and an essence, characterized by: Prepare according to the following steps, S1: preparing a cold compress cover, weighing carbonamide and a high molecular weight water-absorbing resin according to a formula ratio, screening the carbonamide and adding it into a mixer, then adding the high molecular weight water-absorbing resin and mixing and stirring to form a cold compress inner material, and then forming, spraying glue, punching, folding, bagging, and sealing the cold compress cover; S2 preparation of Chinese herbal medicine extract, according to the mass ratio weighed wild chrysanthemum, salvia miltiorrhiza, phellodendron, the three direct-collecting Chinese herbal medicines by decoction extraction filtration, vacuum concentration, tubular separation, refrigeration to obtain Chinese herbal medicine extract; S3. Prepare the essence by mixing the herbal extract, excipients, and multi-carrier penetration enhancers in a mass ratio to form an essence; S4. The essence is filled, sealed, irradiated, and finally packaged together with the cold compress mask.

5. The production process of a cold compress mask and essence according to claim 4, characterized in that: In step S1, carbonamide is passed through a 40-45 mesh screen, and carbonamide and a high molecular water-absorbing resin are mixed and stirred for 30-40 minutes.

6. The production process of a cold compress mask and essence according to claim 4, characterized in that: In step S2, the boiling temperature is 100°C, the refrigeration temperature is -3°C to 4°C, and the refrigeration time is more than 24 hours.

7. The production process of a cold compress mask and essence according to claim 4, characterized in that: In step S2, a double-effect vacuum concentration process is used, the steam pressure of the effect I heater is controlled at ≤0.2MPa, the heating temperature is controlled at 70℃~80℃, the vacuum degree is controlled at -0.04MPa~-0.06MPa, and the temperature of the effect II concentrator is controlled at 60℃~70℃, and the vacuum degree is controlled at -0.06MPa~-0.07MPa.

8. The production process of a cold compress mask and essence according to claim 4, characterized in that: In step S2, the three Chinese herbal extracts are mixed and decocted, with a density of 1.0-2.0, and the amount of paste collected is 65kg±10kg / time.

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