Heart-tonifying, kidney-tonifying and nerve-soothing cream formula and preparation method thereof

Abstract

The invention discloses a heart-tonifying, kidney-tonifying and nerve-soothing cream formula and a preparation method thereof. On one hand, the invention discloses a heart-tonifying kidney-tonifying nerve-soothing cream formula. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 10 to 30 parts of radix angelicae sinensis, 10 to 30 parts of radix paeoniae alba, 15 to 30 parts of radix rehmanniae preparata, 10 to 20 parts of radix ginseng, 10 to 25 parts of rhizoma atractylodis macrocephalae, 5 to 10 parts of liquorice root, 15 to 30 parts of poria cocos, 15 to 30 parts of radix astragali seu hedysari, 3 to 10 parts of cortex cinnamomi, 5 to 15 parts of fructus schisandrae chinensis, 10 to 20 parts of radix polygalae, 10 to 30 parts of poria with hostwood, 10 to 30 parts of fried semen ziziphi spinosae, 5 to 15 parts of pericarpium citri reticulatae, 10 to 30 parts of radix salviae miltiorrhizae, 5 to 15 parts of human placenta, 10 to 30 parts of semen coicis, 3 to 10 parts of fructus amomi, 10 to 30 parts of and 10-20 parts of deer-horn glue. On the other hand, the invention further provides a preparation method of the heart-tonifying, kidney-tonifying and nerve-soothing cream formula. The traditional Chinese medicine composition has the advantages of treating heart, spleen and kidney at the same time so as to meet the comprehensive recuperating requirements of modern people with complicated chronic insomnia pathogenesis, sub-health and weak body for long-term recuperating.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparations, and more particularly to a prescription for nourishing the heart, replenishing the kidneys and calming the mind paste and a preparation method thereof. Background Art

[0002] Insomnia refers to a group of clinical syndromes that include difficulty falling asleep, maintaining sleep, waking up early or having poor sleep quality, leading to impaired daytime social function and excluding the effects of other sleep disorders, physical illnesses or medications. It is one of the most common neurological diseases in modern society. If the symptoms persist for more than three months, it is called chronic insomnia. According to statistics, insomnia is the most common sleep disorder in the world, with symptoms of sleep disturbance and difficulty falling asleep. Insomnia has become a common problem that seriously affects public health. Its harm not only leads to daytime fatigue, inattention and decreased cognitive function, significantly reducing work and study efficiency and quality of life, but is also an important risk factor for inducing or aggravating anxiety, depression, cardiovascular disease and other diseases.

[0003] Chronic insomnia is detrimental to physical and mental health, impacting quality of life. It is accompanied by changes in mood and cognition, and is a high risk factor for accidents and death. In Traditional Chinese Medicine, insomnia is known as "insomnia," and has been systematically documented in ancient texts such as the Yellow Emperor's Classic of Internal Medicine. TCM believes that insomnia is associated with imbalances in Qi, blood, Yin and Yang, and visceral dysfunction, particularly with the heart, spleen, and kidneys. It is more common in chronic insomnia sufferers with a long course, the elderly, those with comorbid cardiovascular and cerebrovascular diseases, or those with physical weakness.

[0004] Currently, the main intervention methods for insomnia are cognitive behavioral therapy and benzodiazepines. Drug interventions, such as those involving agonists, are often used. However, the former is limited by the need for face-to-face intervention, while the latter can lead to adverse reactions such as addiction, dependence, and withdrawal. In contrast, Traditional Chinese Medicine (TCM) offers unique advantages in treating insomnia. In particular, TCM's syndrome differentiation and health care approach, based on syndrome differentiation and focused on adjusting sub-health conditions, combined with TCM's specialized dosage forms—pastes—deliver a slow and sustained release of efficacy, gradually adjusting the body's constitution and repairing deficiencies. This approach is a preferred option for treating chronic insomnia.

[0005] The inventors have discovered through long-term clinical research that chronic insomnia sufferers commonly suffer from both deficiency of the heart, spleen, and blood, as well as kidney-essence deficiency. As insomnia progresses, kidney-essence deficiency worsens, further exacerbating the symptoms and condition, making insomnia more persistent and difficult to cure, creating a vicious cycle. Therefore, treating chronic insomnia requires prioritizing kidney-tonifying and replenishing essence in addition to tonifying the heart and spleen, in order to achieve a comprehensive treatment of both the symptoms and the root cause.

[0006] Paste prescriptions, also known as "paste nourishing medicines," are traditional Chinese medicines that offer both advanced nutritional and tonic properties, combined with preventive and therapeutic benefits. These are large-scale compound decoctions formulated based on comprehensive TCM syndrome differentiation, according to the patient's constitution, symptom presentation, disease progression, or changing constitution. They are concentrated and then decocted with nourishing excipients to create a thick, semi-fluid Chinese patent medicine. They boast high concentration, slow and long-lasting efficacy, both tonifying and curative properties, convenient oral administration, no need for decoction, and portability. They are suitable for people living in today's fast-paced lives, particularly those with physical weakness, sub-health conditions, chronic illnesses, children, women, the elderly, and other special populations. Their use in modern clinical practice is becoming increasingly widespread.

[0007] Although there are many Chinese patent medicines and pastes for insomnia intervention on the market, such as those for nourishing the heart and calming the mind, tonifying the kidney and calming the mind, etc., most of these products focus on the conditioning of a single internal organ (such as focusing on heart blood, liver depression or only tonifying the kidney), and fail to take into account the simultaneous treatment of the heart, spleen and kidney. There are obvious deficiencies in the intervention of complex chronic insomnia such as deficiency of qi, blood and yin essence, endogenous phlegm and dampness. At the same time, existing preparations lack systematicity in the synergy of multiple targets such as nourishing and removing dampness, calming the mind and strengthening the spleen, and are difficult to meet the long-term conditioning needs of modern chronic insomnia with complex pathogenesis, sub-health and physical weakness. Therefore, it is of great significance and application value to develop a Chinese medicine paste that can both tonify the heart and kidney, strengthen the spleen and eliminate dampness, calm the mind and stabilize the spirit, and is suitable for long-term conditioning. Summary of the Invention

[0008] The first object of the present invention is to provide a heart-tonifying, kidney-benefiting and mind-soothing ointment that can treat the heart, spleen and kidney simultaneously to meet the long-term conditioning needs of modern chronic insomnia patients with complex pathogenesis, sub-health and physical weakness.

[0009] The second object of the present invention is to provide a method for preparing the above-mentioned heart-tonifying, kidney-benefiting and mind-calming ointment.

[0010] To achieve the above object, the present invention adopts the following technical solutions:

[0011] On the one hand, a prescription for nourishing the heart, benefiting the kidneys and calming the mind is composed of the following components in parts by weight: 10-30 parts of angelica sinensis, 10-30 parts of white peony root, 15-30 parts of cooked rehmannia, 10-20 parts of ginseng, 10-25 parts of white atractylodes, 5-10 parts of licorice, 15-30 parts of poria, 15-30 parts of astragalus, 3-10 parts of cinnamon, 5-15 parts of schisandra chinensis, 10-20 parts of polygala tenuifolia, 10-30 parts of poria, 10-30 parts of stir-fried jujube seeds, 5-15 parts of tangerine peel, 10-30 parts of salvia miltiorrhiza, 5-15 parts of placenta, 10-30 parts of coix seed, 3-10 parts of amomum villosum, 10-30 parts of ginger, 100-200 parts of honey, and 10-20 parts of antler glue.

[0012] Preferably, a prescription for a nourishing heart, kidney and tranquilizing paste comprises 10 parts of angelica, 10 parts of white peony root, 15 parts of cooked rehmannia, 10 parts of ginseng, 10 parts of white atractylodes, 5 parts of licorice, 15 parts of poria, 15 parts of astragalus, 3 parts of cinnamon, 5 parts of schisandra, 10 parts of polygala, 10 parts of poria, 10 parts of stir-fried spinach seeds, 5 parts of tangerine peel, 10 parts of salvia miltiorrhiza, 5 parts of placenta, 10 parts of coix seed, 3 parts of amomum, 10 parts of ginger, 100 parts of honey and 10 parts of antler glue.

[0013] Preferably, a prescription for nourishing the heart, benefiting the kidneys and calming the mind paste is composed of the following components in parts by weight: 20 parts of angelica sinensis, 20 parts of white peony root, 22.5 parts of cooked rehmannia, 15 parts of ginseng, 17.5 parts of white atractylodes, 7.5 parts of licorice, 22.5 parts of poria, 22.5 parts of astragalus, 6.5 parts of cinnamon, 10 parts of schisandra chinensis, 15 parts of polygala tenuifolia, 20 parts of poria, 20 parts of stir-fried jujube seeds, 10 parts of tangerine peel, 20 parts of salvia miltiorrhiza, 10 parts of placenta, 20 parts of coix seed, 6.5 parts of amomum villosum, 20 parts of ginger, 150 parts of honey, and 15 parts of antler glue.

[0014] Preferably, a prescription for a nourishing heart, kidney and tranquilizing paste comprises 30 parts of angelica, 30 parts of white peony root, 30 parts of cooked rehmannia, 20 parts of ginseng, 25 parts of white atractylodes, 10 parts of licorice, 30 parts of poria, 30 parts of astragalus, 10 parts of cinnamon, 15 parts of schisandra, 20 parts of polygala, 30 parts of poria, 30 parts of stir-fried spiny jujube seeds, 15 parts of tangerine peel, 30 parts of salvia miltiorrhiza, 15 parts of placenta, 30 parts of coix seed, 10 parts of amomum, 30 parts of ginger, 200 parts of honey and 20 parts of antler glue.

[0015] On the other hand, a preparation method of the heart-tonifying, kidney-benefiting and mind-calming ointment is provided, the preparation method comprising the following steps:

[0016] S1. According to the predetermined ratio, weigh the predetermined amount of angelica, white peony root, prepared rehmannia, white atractylodes, liquorice, poria, astragalus, schisandra, polygala, poria, tangerine peel, salvia miltiorrhiza, coix seed, and amomum villosum respectively, put them into a clean cloth bag and soak them in purified water 6-8 times the weight of the medicinal materials in this step for 7-9 hours;

[0017] S2. Weigh predetermined amounts of ginseng and placenta, respectively, and place them in corresponding external containers. Add purified water 7-9 times the weight of the ginseng or placenta to the corresponding containers, respectively, and soak them at room temperature for 7-9 hours. Then, decoct the ginseng and placenta separately twice within a predetermined time using a slow fire to obtain ginseng and placenta medicinal solutions for later use.

[0018] S3, weighing a predetermined amount of Poria cocos, and subjecting the Poria cocos to a vacuum freeze-drying treatment, wherein the Poria cocos is frozen and freeze-dried at a temperature of ≤-40° C. to obtain a freeze-dried Poria cocos product, wherein the moisture content of the freeze-dried Poria cocos product is less than 5 wt %;

[0019] S4. Weighing a predetermined amount of stir-fried Chinese jujube seeds, and extracting the effective components of the Chinese jujube seeds using a predetermined alcohol extraction-water extraction combined process to obtain a stir-fried Chinese jujube seed extract containing fat-soluble tranquilizing components and water-soluble components for later use;

[0020] S5. Weigh a predetermined amount of cinnamon and pack it in a separate bag for later use;

[0021] S6. After crushing the antler glue, place it in a water bath at 60-80°C and melt it until it dissolves into antler glue liquid;

[0022] S7, putting the soaked mixed medicinal materials of step S1 and the freeze-dried Poria cocos of step S3 into a copper pot together, and adding purified water 6-8 times the weight of the sum of the mixed medicinal materials in step S1 and the freeze-dried Poria cocos slices in step S3, decocting twice over a predetermined time with a slow fire, and adding the cinnamon of step S5 20 minutes before the end of the second decoction to avoid the cinnamon decoction time being too long and causing the active ingredient to volatilize and lose, and filtering with an 80-100 mesh sieve after each decoction to obtain a decoction liquid;

[0023] S8, combining the decoction of step S7 with the ginseng and placenta medicinal liquids of step S2 and the stir-fried jujube seed extract of step S4 to obtain a combined medicinal liquid, filtering the combined medicinal liquid 2-3 times with an 80-100 mesh sieve to obtain a medicinal liquid filtrate, then slowly adding the antler glue of step S6 to the filtrate and stirring to mix, then decocting the medicinal liquid filtrate over a low heat of 70-80° C., adding melted honey in predetermined times during the decoction and continuously stirring to condense the paste into a beaded or honeycomb-shaped paste;

[0024] S9. While the paste is still hot, divide it into pre-sterilized glass bottles, and then use high-pressure steam at 115℃-125℃ to sterilize the glass bottles containing the paste for 20-30 minutes. After cooling, seal and store them, and implement quality management according to preset standards to facilitate long-term storage and clinical application.

[0025] Preferably, in step S2, the preparation of the ginseng medicinal solution and the placenta medicinal solution comprises the following steps:

[0026] S2.1. Weigh a predetermined amount of ginseng and placenta, respectively, and place them in corresponding external containers. Add 8 times the weight of ginseng or placenta to the corresponding containers in purified water, soak them at room temperature for 8 hours, and then simmer the ginseng and placenta separately for 1 hour each to obtain the first ginseng decoction and the first placenta decoction, which are then taken out for later use.

[0027] S2.2, again to the corresponding container were added ginseng or placenta 8 times the weight of pure water, again using a slow fire for ginseng and placenta were decocted again, the decoction time was 1 hour each, to obtain the second ginseng decoction and the second placenta decoction and take out for later use;

[0028] S2.3. Combine the first ginseng decoction of step S2.1 and the second ginseng decoction of step S2.2 to obtain ginseng medicinal liquid; combine the first placenta decoction of step S2.1 and the second placenta decoction of step S2.2 to obtain placenta medicinal liquid, so as to facilitate subsequent combination with the total medicinal liquid.

[0029] Preferably, in step S4, the preparation of the stir-fried spinach kernel extract comprises the following steps:

[0030] S4.1. Weigh a predetermined amount of stir-fried Chinese jujube seeds and extract their components using a combined alcohol-water extraction process. Specifically, based on the solubility of the solvents, first extract the stir-fried Chinese jujube seeds by heating and refluxing at 70-80°C with an ethanol-water solution having a volume ratio of 70% water to ethanol, with the stir-fried Chinese jujube seeds and ethanol-water solution being in a weight ratio of 1:8-10. Reflux for 2 hours, repeating twice, and then concentrating under reduced pressure at 55-65°C to remove the alcohol to obtain the fat-soluble tranquilizing component of the stir-fried Chinese jujube seeds.

[0031] S4.2. After extracting the fat-soluble tranquilizing component, the stir-fried Ziziphus jujuba seed residue is filtered and washed thoroughly with purified water until no ethanol residue remains. The stir-fried Ziziphus jujuba seed residue is then boiled in purified water (6-8 times the weight of the Ziziphus jujuba seed residue) at normal pressure and 90±2°C for 1.5 hours to obtain the water-soluble component of the stir-fried Ziziphus jujuba seed residue.

[0032] S4.3. Combine the fat-soluble sedative component of step S4.1 and the water-soluble component of step S4.2 at a volume ratio of 1:3 to obtain a stir-fried jujube seed extract.

[0033] Preferably, in step S7, the preparation of the decoction comprises the following steps:

[0034] S7.1. Place the soaked mixed medicinal materials from step S1 and the freeze-dried Poria cocos from step S3 into a copper pot, add purified water 6-8 times the weight of the combined mixed medicinal materials from step S1 and the freeze-dried Poria cocos from step S3, and simmer once for 1.5 hours. After simmering, filter through an 80-100 mesh sieve to obtain a first decoction.

[0035] S7.2. Decoction the first decoction again over low heat for 1.5 hours.

[0036] In addition, the cinnamon bark in step S5 is added 20 minutes before the end of the decoction to prevent the cinnamon bark from being decocted for too long and causing the active ingredients to be volatilized and lost. After the decoction is completed, the decoction is filtered using an 80-mesh to 100-mesh sieve to obtain a decoction liquid.

[0037] Among them, in step S9, the preset standards for quality management of glass bottles with pastes are: the quality control standards are implemented in accordance with the predetermined paste prescription internal control standards: the relative density should be ≥1.40 (25°C), the total microbial limit colony count ≤100CFU / g, mold and yeast ≤10CFU / g, and no pathogenic bacteria shall be detected; the content of heavy metals and pesticide residues strictly complies with the requirements of the "Quality Management Standards for the Production of Chinese Medicinal Materials".

[0038] The heart-tonifying, kidney-benefiting and tranquilizing ointment of the present invention can be used to treat chronic insomnia and related syndromes caused by deficiency of the heart, spleen and kidney, among others. Chronic insomnia and related syndromes include: persistent insomnia, frequent awakenings, difficulty falling asleep, frequent awakenings at night, daytime fatigue, palpitations, shortness of breath, forgetfulness, frequent urination, poor appetite, dizziness and tinnitus caused by deficiency of the heart, spleen and kidney, deficiency of qi, blood, yin and essence, failure of water to contain wood, and internal disturbance of virtual fire.

[0039] Compared with the prior art, the present invention has the following beneficial effects:

[0040] 1. In the present invention, the Chinese medicine combination in the prescription can nourish the heart blood, benefit the kidney essence, strengthen the spleen qi, drain phlegm and dampness, and calm the mind. It can treat chronic insomnia caused by various heart, spleen and kidney deficiency. Compared with the single Chinese patent medicine sold on the market that can soothe the liver and clear away heat, strengthen the spleen and nourish the blood and nourish the heart, or connect the heart and kidney, this prescription focuses on solving the pathogenesis of nourishing the spleen and kidney and strengthening the spleen to promote qi and resolve phlegm and calm the mind. It uses ginseng, astragalus, and white atractylodes to strengthen the spleen and replenish vital energy, angelica and white peony to replenish blood and nourish yin, and cooked rehmannia and cinnamon bark to strengthen the spleen and replenish vital energy. , placenta nourishes the kidney, replenishes essence, warms and strengthens primordial yang, Poria, Coix seed, Tangerine peel, Amomum villosum, strengthens the spleen and promotes qi circulation and eliminates phlegm and dampness, reducing the interference of phlegm and dampness on the soul and making it difficult to fall asleep, and is supplemented by Ziziphus jujuba seed, Poria, Schisandra chinensis, and Polygala tenuifolia to calm the nerves and soothe the mind, and is assisted by Salvia miltiorrhiza to promote blood circulation and unblock the meridians. The whole prescription has the effects of nourishing blood and benefiting the kidney, strengthening the spleen and eliminating dampness, promoting blood circulation and soothing the mind. The prescription of the present invention has a unique efficacy, and the three internal organs of the heart, kidney and spleen are coordinated, nourishing the heart and spleen while benefiting the essence and producing marrow, and nourishing the deficiency and soothing the mind are its characteristics and advantages. Therefore, the present invention has the advantage of treating the three internal organs of the heart, spleen and kidney at the same time to meet the comprehensive conditioning needs of modern chronic insomnia with complex pathogenesis, sub-health and physical weakness.

[0041] 2. This Chinese herbal combination is used to treat chronic insomnia and related syndromes caused by heart, spleen, and kidney deficiency, including but not limited to persistent insomnia, frequent awakenings, difficulty falling asleep, frequent nighttime awakenings, daytime fatigue, palpitations, shortness of breath, forgetfulness, frequent urination, poor appetite, dizziness, and tinnitus, all caused by heart, spleen, and kidney deficiency, qi, blood, and yin essence deficiency, water failing to contain wood, and internal disturbance of virtual fire. This Chinese herbal combination can significantly improve these symptoms and enhance sleep quality, and has value in the long-term conditioning of patients with physical weakness, sub-health, and chronic cardiovascular and cerebrovascular diseases. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0043] Figure 1 This is a graph showing the results of a mouse end latency reversal experiment using a heart-tonifying, kidney-tonifying, and mind-calming ointment according to the present invention;

[0044] Figure 2 This is a schematic diagram of the experimental results of the sleep time correction of mice after the end of sleep using the heart-tonifying, kidney-tonifying and mind-calming ointment of the present invention;

[0045] Figure 3 Schematic diagram of the open field test analysis of the total distance traveled into the central area by mice after administration of the Bu Xin Yi Shen An Shen ointment of the present invention;

[0046] Figure 4 This is a schematic diagram of an open field test analysis of the number of times mice entered the central area after being administered the Bu Xin Yi Shen An Shen ointment of the present invention;

[0047] Figure 5 This is a schematic diagram of an open field test analysis of the time taken by mice to enter the central area after administration of the Bu Xin Yi Shen An Shen ointment of the present invention;

[0048] Figure 6 This is a graph showing the results of a novel object recognition experiment on mice using the heart-tonifying, kidney-benefiting and mind-calming ointment described in the present invention.

[0049] Explanation of the accompanying symbols: * represents P<0.1, ** represents P<0.01, *** represents P<0.001, and **** represents P<0.0001. DETAILED DESCRIPTION

[0050] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of them. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0051] Reference Figures 1 to 6 As shown, the present invention provides a prescription for nourishing the heart, replenishing the kidney and calming the mind paste, which is composed of the following components in parts by weight: 10-30 parts of angelica sinensis, 10-30 parts of white peony root, 15-30 parts of cooked rehmannia, 10-20 parts of ginseng, 10-25 parts of white atractylodes, 5-10 parts of liquorice, 15-30 parts of poria, 15-30 parts of astragalus, 3-10 parts of cinnamon, 5-15 parts of schisandra chinensis, 10-20 parts of polygala tenuifolia, 10-30 parts of poria, 10-30 parts of stir-fried spinach seeds, 5-15 parts of tangerine peel, 10-30 parts of salvia miltiorrhiza, 5-15 parts of placenta, 10-30 parts of coix seed, 3-10 parts of amomum villosum, 10-30 parts of ginger, 100-200 parts of honey, and 10-20 parts of antler glue.

[0052] The present invention also provides a preparation method of the heart-tonifying, kidney-benefiting and mind-calming ointment, which comprises the following steps:

[0053] S1. According to a predetermined ratio, weigh a predetermined amount of angelica sinensis, white peony root, prepared rehmannia root, white atractylodes macrocephala, liquorice, poria, astragalus, schisandra chinensis, polygala root, poria, tangerine peel, salvia miltiorrhiza, coix seed, and amomum villosum, and put them into a clean cloth bag and soak them in 6-8 times the weight of the medicinal materials in this step with purified water for 7-9 hours, for example, adding 6 times the weight, 7 times the weight, or 8 times the weight of purified water, for example, soaking for 7 hours, 8 hours, or 9 hours;

[0054] S2. Weigh predetermined amounts of ginseng and placenta, respectively, and place them in corresponding external containers. Add 7-9 times the weight of purified water of ginseng or placenta to the corresponding containers, respectively. That is, add 7-9 times the weight of purified water of ginseng, for example, 7 times the weight, 8 times the weight, or 9 times the weight of purified water, to the container containing ginseng. Add 7-9 times the weight of purified water of placenta, for example, 7 times the weight, 8 times the weight, or 9 times the weight of purified water to the container containing placenta. Soak the ginseng and placenta separately twice within a predetermined time under low heat to obtain ginseng and placenta medicinal solutions for later use.

[0055] S3, weighing a predetermined amount of Poria cocos, performing a vacuum freeze-drying process on the Poria cocos, performing a vacuum freeze-drying process on the Poria cocos, wherein the Poria cocos is frozen and freeze-dried at a temperature of ≤-40° C. to obtain a freeze-dried Poria cocos product, wherein the moisture content of the freeze-dried Poria cocos product is less than 5 wt %, so as to improve the stability and efficacy of the paste prescription.

[0056] S4. Weighing a predetermined amount of stir-fried Chinese jujube seeds, and extracting the effective components of the Chinese jujube seeds using a predetermined alcohol extraction-water extraction combined process to obtain a stir-fried Chinese jujube seed extract containing fat-soluble tranquilizing components and water-soluble components for later use;

[0057] S5. Weigh a predetermined amount of cinnamon and pack it in a separate bag for later use;

[0058] S6. After crushing the antler glue, place it in a water bath at 60-80°C and melt it until it dissolves into antler glue liquid;

[0059] S7, putting the soaked mixed medicinal materials of step S1 and the freeze-dried Poria cocos of step S3 into a copper pot together, and adding purified water 6-8 times the weight of the sum of the mixed medicinal materials in step S1 and the freeze-dried Poria cocos slices in step S3, decocting twice with a slow fire within a predetermined time, and adding the cinnamon of step S5 20 minutes before the end of the second decoction to avoid the cinnamon decoction time being too long and causing the active ingredient to volatilize and lose, and filtering with an 80-100 mesh sieve after each decoction, such as 80 mesh, 90 mesh or 100 mesh, to obtain a decoction liquid;

[0060] S8, combining the decoction of step S7 with the ginseng and placenta medicinal liquids of step S2 and the stir-fried jujube seed extract of step S4 to obtain a combined medicinal liquid, filtering the combined medicinal liquid 2-3 times with an 80-100 mesh sieve to obtain a medicinal liquid filtrate, such as an 80-mesh, 90-mesh, or 100-mesh sieve, then slowly adding the antler glue of step S6 to the filtrate and stirring to mix, then decocting the medicinal liquid filtrate over a low heat of 70-80° C., adding melted honey in predetermined times during the decocting period and continuously stirring to condense the paste into a beaded or honeycomb-shaped paste;

[0061] S9. While the paste is still hot, divide it into pre-sterilized glass bottles, and then use high-pressure steam at 115℃-125℃ to sterilize the glass bottles with the paste for 20-30 minutes, for example: 115℃ or 121℃ or 125℃. After cooling, seal and store them, and implement quality management according to preset standards for long-term storage and clinical application.

[0062] In the present invention, the preparation of the ginseng medicinal solution and the placenta medicinal solution comprises the following steps:

[0063] S2.1. Weigh a predetermined amount of ginseng and placenta, respectively, and place them in corresponding external containers. Add 8 times the weight of ginseng or placenta to the corresponding containers in purified water, soak them at room temperature for 8 hours, and then simmer the ginseng and placenta separately for 1 hour each to obtain the first ginseng decoction and the first placenta decoction, which are then taken out for later use.

[0064] S2.2, again to the corresponding container were added ginseng or placenta 8 times the weight of pure water, again using a slow fire for ginseng and placenta were decocted again, the decoction time was 1 hour each, to obtain the second ginseng decoction and the second placenta decoction and take out for later use;

[0065] S2.3. Combine the first ginseng decoction of step S2.1 and the second ginseng decoction of step S2.2 to obtain ginseng medicinal liquid; combine the first placenta decoction of step S2.1 and the second placenta decoction of step S2.2 to obtain placenta medicinal liquid, so as to facilitate subsequent combination with the total medicinal liquid.

[0066] In the present invention, in step S4, the preparation of the stir-fried spinach seed extract comprises the following steps:

[0067] S4.1. Weigh a predetermined amount of stir-fried Chinese date seeds and extract the components using a combined alcohol-water extraction process.

[0068] The method comprises the following steps: firstly extracting the stir-fried spinach seeds by heating under reflux at a weight ratio of 1:8-10, such as 1:8, 1:9 or 1:10, at a volume ratio of 70% by volume of an ethanol-water solution based on the solubility of the solvent, and then refluxing for 2 hours, repeating the process twice, and then performing a decompression concentration at 55-65°C to remove the alcohol, so as to obtain the fat-soluble tranquilizing component of the stir-fried spinach seeds;

[0069] S4.2. After extracting the fat-soluble tranquilizing component, the stir-fried Ziziphus jujuba seed residue is filtered and washed thoroughly with purified water until no ethanol residue remains. The stir-fried Ziziphus jujuba seed residue is then boiled in purified water (6-8 times the weight of the Ziziphus jujuba seed residue) at normal pressure and 90±2°C for 1.5 hours to obtain the water-soluble component of the stir-fried Ziziphus jujuba seed residue.

[0070] S4.3. Combine the fat-soluble sedative component of step S4.1 and the water-soluble component of step S4.2 at a volume ratio of 1:3 to obtain a stir-fried jujube seed extract.

[0071] In the present invention, in step S7, the preparation of the decoction comprises the following steps:

[0072] S7.1. Place the soaked mixed medicinal materials from step S1 and the freeze-dried Poria cocos from step S3 into a copper pot, add purified water 6-8 times the weight of the combined mixed medicinal materials from step S1 and the freeze-dried Poria cocos from step S3, and simmer once for 1.5 hours. After simmering, filter through an 80-100 mesh sieve to obtain a first decoction.

[0073] S7.2. The first decoction is decocted again over low heat for 1.5 hours. The cinnamon bark from step S5 is added 20 minutes before the end of the second decoction to prevent the cinnamon bark from volatilizing and losing its active ingredients due to prolonged decoction. After the decoction is completed, the decoction is filtered through an 80-100 mesh sieve to obtain the decoction.

[0074] The ginseng used in the present invention is all five-year-old forest ginseng from Jilin, which has pure medicinal effect and can ensure the clinical efficacy of the paste prescription.

[0075] In the present invention, in step S9, the preset standards for quality management of glass bottles with pastes are: the quality control standards are implemented in accordance with the predetermined paste prescription internal control standards: the relative density should be ≥1.40 (25°C), the total microbial limit colony count should be ≤100CFU / g, the mold and yeast should be ≤10CFU / g, and pathogenic bacteria should not be detected; the content of heavy metals and pesticide residues strictly complies with the requirements of the "Quality Management Standards for the Production of Chinese Medicinal Materials".

[0076] The heart-tonifying, kidney-benefiting and tranquilizing ointment of the present invention can be used to treat chronic insomnia and related syndromes caused by deficiency of the heart, spleen and kidney, among others. Chronic insomnia and related syndromes include: persistent insomnia, frequent awakenings, difficulty falling asleep, frequent awakenings at night, daytime fatigue, palpitations, shortness of breath, forgetfulness, frequent urination, poor appetite, dizziness and tinnitus caused by deficiency of the heart, spleen and kidney, deficiency of qi, blood, yin and essence, failure of water to contain wood, and internal disturbance of virtual fire.

[0077] The present invention has 5 preferred formulations, which are as follows:

[0078] Preferred formula 1, a prescription for nourishing the heart, benefiting the kidneys and calming the mind, is composed of the following components in parts by weight: 10 parts of angelica sinensis, 10 parts of white peony root, 15 parts of cooked rehmannia, 10 parts of ginseng, 10 parts of white atractylodes, 5 parts of licorice, 15 parts of poria, 15 parts of astragalus, 3 parts of cinnamon, 5 parts of schisandra chinensis, 10 parts of polygala tenuifolia, 10 parts of poria, 10 parts of stir-fried jujube seeds, 5 parts of tangerine peel, 10 parts of salvia miltiorrhiza, 5 parts of placenta, 10 parts of coix seed, 3 parts of amomum villosum, 10 parts of ginger, 100 parts of honey, and 10 parts of antler glue.

[0079] Example 1

[0080] The preparation of the Buxin Yishen Anshen ointment prescription of the present embodiment specifically comprises the following steps:

[0081] 1) According to the predetermined ratio, weigh 10 parts of Chinese Angelica sinensis, 10 parts of white peony root, 15 parts of Rehmannia glutinosa, 10 parts of ginseng, 10 parts of Atractylodes macrocephala, 5 parts of liquorice, 15 parts of Poria cocos, 15 parts of Astragalus membranaceus, 3 parts of cinnamon bark, 5 parts of Schisandra chinensis, 10 parts of Polygala tenuifolia, 10 parts of Poria cocos, 10 parts of stir-fried Ziziphus jujuba seeds, 5 parts of dried tangerine peel, 10 parts of Salvia miltiorrhiza, 5 parts of placenta, 10 parts of Coix seed, 3 parts of Amomum villosum, 10 parts of ginger, 100 parts of honey, and 10 parts of antler glue;

[0082] 2) Place the remaining herbs, except ginseng, placenta, poria, stir-fried jujube seeds, cinnamon, and honey, into a clean cloth bag. Add purified water (6-8 times the weight of the herbs) to the bag and soak at room temperature for 8 hours to obtain a mixed herbal mixture.

[0083] 3) placing ginseng and placenta in corresponding external containers, adding purified water 8 times the weight of ginseng or placenta to the corresponding containers, soaking them at room temperature for 8 hours, and then decocting the ginseng and placenta separately once with a slow fire for 1 hour each, to obtain a first ginseng decoction and a first placenta decoction, which are then taken out for later use; adding purified water 8 times the weight of ginseng or placenta to the corresponding containers again, and decocting the ginseng and placenta separately once with a slow fire for 1 hour each, to obtain a second ginseng decoction and a second placenta decoction, which are then taken out for later use; combining the first ginseng decoction and the second ginseng decoction to obtain a ginseng medicinal liquid; combining the first placenta decoction and the second placenta decoction to obtain a placenta medicinal liquid, so as to facilitate subsequent combination with the total medicinal liquid;

[0084] 4) subjecting the Poria cocos to a vacuum freeze-drying treatment, wherein the Poria cocos is frozen and freeze-dried at a temperature of ≤-40° C. to obtain a freeze-dried Poria cocos product having a moisture content of less than 5 wt %, so as to improve the stability and efficacy of the paste prescription and prepare the freeze-dried Poria cocos product for later use;

[0085] 5) Based on the different solubilities of the solvents, the stir-fried spinach seeds are first subjected to heating reflux extraction using an ethanol-water solution having a volume ratio of water to ethanol of 70% by volume at 70-80° C., the reflux is repeated twice, and the stir-fried spinach seeds are subjected to reduced pressure concentration at 60° C. to remove the alcohol to obtain the fat-soluble tranquilizing component of the stir-fried spinach seeds; the stir-fried spinach seeds residue after the fat-soluble tranquilizing component is extracted is filtered and separated, and the stir-fried spinach seeds residue is thoroughly washed with purified water until no ethanol residue is left, and then the stir-fried spinach seeds residue is decocted with purified water 6-8 times the weight of the spinach seeds residue at normal pressure of 90±2° C. for 1.5 hours to obtain the water-soluble component of the stir-fried spinach seeds residue; the fat-soluble tranquilizing component and the water-soluble component are combined in a volume ratio of 1:3 to obtain a stir-fried spinach seeds extract for later use;

[0086] 6) Bag the cinnamon separately for later use;

[0087] 7) Crush the antler glue and place it in a 60-80°C water bath to dissolve into antler glue liquid. Then slowly add the antler glue liquid to the aforementioned mixed solution and stir thoroughly to mix.

[0088] 8) placing the mixed medicinal materials and the freeze-dried Poria cocos into a copper pot, adding purified water 6-8 times the weight of the combined weight of the mixed medicinal materials and the freeze-dried Poria cocos, and decocting once over low heat for 1.5 hours. After the decoction is completed, filtering through an 80-100 mesh sieve to obtain a first decoction; decocting the first decoction again over low heat for 1.5 hours, adding cinnamon 20 minutes before the end of the second decoction to prevent the cinnamon from volatilizing and losing its active ingredients due to prolonged decoction. After the decoction is completed, filtering through an 80-100 mesh sieve to obtain a decoction liquid;

[0089] 9) combining the decoction with the ginseng and placenta extracts and the stir-fried jujube seed extract to obtain a combined solution, filtering the combined solution 2-3 times through an 80-100 mesh sieve to obtain a filtrate, then slowly adding the antler glue solution to the filtrate and stirring to mix thoroughly, and then decocting the filtrate over a low heat at 70-80° C. During the decoction, adding melted honey in predetermined portions and stirring continuously to concentrate the paste into a bead-like or honeycomb-shaped paste, and finally collecting the paste when the paste is formed into beads or a flag-like consistency;

[0090] 10) While the paste is still hot, divide it into pre-sterilized glass bottles, sterilize the glass bottles with paste using high-pressure steam at 121°C for 20-30 minutes, seal and store after cooling, and implement quality management according to preset standards for long-term storage and clinical application.

[0091] Preferred formula 2, a heart-tonifying, kidney-benefiting and mind-soothing paste prescription, is composed of the following components in parts by weight: 20 parts of angelica sinensis, 20 parts of white peony root, 22.5 parts of cooked rehmannia, 15 parts of ginseng, 17.5 parts of white atractylodes, 7.5 parts of licorice, 22.5 parts of poria, 22.5 parts of astragalus, 6.5 parts of cinnamon, 10 parts of schisandra chinensis, 15 parts of polygala tenuifolia, 20 parts of poria, 20 parts of stir-fried jujube seeds, 10 parts of tangerine peel, 20 parts of salvia miltiorrhiza, 10 parts of placenta, 20 parts of coix seed, 6.5 parts of amomum villosum, 20 parts of ginger, 150 parts of honey, and 15 parts of antler glue.

[0092] Example 2

[0093] The preparation of the Buxin Yishen Anshen ointment prescription of the present embodiment specifically comprises the following steps:

[0094] 1) According to the predetermined proportions, weigh 20 parts of Chinese Angelica sinensis, 20 parts of white peony root, 22.5 parts of Rehmannia glutinosa, 15 parts of ginseng, 17.5 parts of Atractylodes macrocephala, 7.5 parts of liquorice, 22.5 parts of Poria cocos, 22.5 parts of Astragalus membranaceus, 6.5 parts of cinnamon bark, 10 parts of Schisandra chinensis, 15 parts of Polygala tenuifolia, 20 parts of Poria cocos, 20 parts of stir-fried Ziziphus jujuba seeds, 10 parts of dried tangerine peel, 20 parts of Salvia miltiorrhiza, 10 parts of placenta, 20 parts of coix seed, 6.5 parts of Amomum villosum, 20 parts of ginger, 150 parts of honey, and 15 parts of antler glue;

[0095] 2) Place the remaining herbs, except ginseng, placenta, poria, stir-fried jujube seeds, cinnamon, and honey, into a clean cloth bag. Add purified water (6-8 times the weight of the herbs) to the bag and soak at room temperature for 8 hours to obtain a mixed herbal mixture.

[0096] 3) placing ginseng and placenta in corresponding external containers, adding purified water 8 times the weight of ginseng or placenta to the corresponding containers, soaking them at room temperature for 8 hours, and then decocting the ginseng and placenta separately once with a slow fire for 1 hour each, to obtain a first ginseng decoction and a first placenta decoction, which are then taken out for later use; adding purified water 8 times the weight of ginseng or placenta to the corresponding containers again, and decocting the ginseng and placenta separately once with a slow fire for 1 hour each, to obtain a second ginseng decoction and a second placenta decoction, which are then taken out for later use; combining the first ginseng decoction and the second ginseng decoction to obtain a ginseng medicinal liquid; combining the first placenta decoction and the second placenta decoction to obtain a placenta medicinal liquid, so as to facilitate subsequent combination with the total medicinal liquid;

[0097] 4) subjecting the Poria cocos to a vacuum freeze-drying treatment, wherein the Poria cocos is frozen and freeze-dried at a temperature of ≤-40° C. to obtain a freeze-dried Poria cocos product having a moisture content of less than 5 wt %, so as to improve the stability and efficacy of the paste prescription and prepare the freeze-dried Poria cocos product for later use;

[0098] 5) Based on the different solubilities of the solvents, the stir-fried spinach seeds are first subjected to heating reflux extraction using an ethanol-water solution having a volume ratio of water to ethanol of 70% by volume at 70-80° C., the reflux is repeated twice, and the stir-fried spinach seeds are subjected to reduced pressure concentration at 60° C. to remove the alcohol to obtain the fat-soluble tranquilizing component of the stir-fried spinach seeds; the stir-fried spinach seeds residue after the fat-soluble tranquilizing component is extracted is filtered and separated, and the stir-fried spinach seeds residue is thoroughly washed with purified water until no ethanol residue is left, and then the stir-fried spinach seeds residue is decocted with purified water 6-8 times the weight of the spinach seeds residue at normal pressure of 90±2° C. for 1.5 hours to obtain the water-soluble component of the stir-fried spinach seeds residue; the fat-soluble tranquilizing component and the water-soluble component are combined in a volume ratio of 1:3 to obtain a stir-fried spinach seeds extract for later use;

[0099] 6) Bag the cinnamon separately for later use;

[0100] 7) Crush the antler glue and place it in a 60-80°C water bath to dissolve into antler glue liquid. Then slowly add the antler glue liquid to the aforementioned mixed solution and stir thoroughly to mix.

[0101] 8) placing the mixed medicinal materials and the freeze-dried Poria cocos into a copper pot, adding purified water 6-8 times the weight of the combined weight of the mixed medicinal materials and the freeze-dried Poria cocos, and decocting once over low heat for 1.5 hours. After the decoction is completed, filtering through an 80-100 mesh sieve to obtain a first decoction; decocting the first decoction again over low heat for 1.5 hours, adding cinnamon 20 minutes before the end of the second decoction to prevent the cinnamon from volatilizing and losing its active ingredients due to prolonged decoction. After the decoction is completed, filtering through an 80-100 mesh sieve to obtain a decoction liquid;

[0102] 9) combining the decoction with the ginseng and placenta extracts and the stir-fried jujube seed extract to obtain a combined solution, filtering the combined solution 2-3 times through an 80-100 mesh sieve to obtain a filtrate, then slowly adding the antler glue solution to the filtrate and stirring to mix thoroughly, and then decocting the filtrate over a low heat at 70-80° C. During the decoction, adding melted honey in predetermined portions and stirring continuously to concentrate the paste into a bead-like or honeycomb-shaped paste, and finally collecting the paste when the paste is formed into beads or a flag-like consistency;

[0103] 10) While the paste is still hot, divide it into pre-sterilized glass bottles, sterilize the glass bottles with paste using high-pressure steam at 121°C for 20-30 minutes, seal and store after cooling, and implement quality management according to preset standards for long-term storage and clinical application.

[0104] Preferred formula 3, a heart-tonifying, kidney-benefiting and mind-soothing paste prescription, is composed of the following components in parts by weight: 15 parts of angelica sinensis, 15 parts of white peony root, 17 parts of cooked rehmannia, 11.5 parts of ginseng, 13 parts of white atractylodes, 6 parts of licorice, 17 parts of poria, 17 parts of astragalus, 5 parts of cinnamon, 7.5 parts of schisandra chinensis, 11 parts of polygala tenuifolia, 15 parts of poria, 15 parts of stir-fried jujube seeds, 7.5 parts of tangerine peel, 15 parts of salvia miltiorrhiza, 7.5 parts of placenta, 15 parts of coix seed, 5 parts of amomum villosum, 17 parts of ginger, and 115 parts of honey.

[0105] Example 3

[0106] The preparation of the Buxin Yishen Anshen ointment prescription of the present embodiment specifically comprises the following steps:

[0107] 1) According to the predetermined proportions, weigh 15 parts of Chinese Angelica sinensis, 15 parts of white peony root, 17 parts of Rehmannia glutinosa, 11.5 parts of ginseng, 13 parts of Atractylodes macrocephala, 6 parts of liquorice, 17 parts of Poria cocos, 17 parts of Astragalus membranaceus, 5 parts of cinnamon bark, 7.5 parts of Schisandra chinensis, 11 parts of Polygala tenuifolia, 15 parts of Poria cocos, 15 parts of stir-fried Ziziphus jujuba seeds, 7.5 parts of dried tangerine peel, 15 parts of Salvia miltiorrhiza, 7.5 parts of placenta, 15 parts of Coix seed, 5 parts of Amomum villosum, 17 parts of ginger, and 115 parts of honey;

[0108] 2) Place the remaining herbs, except ginseng, placenta, poria, stir-fried jujube seeds, cinnamon, and honey, into a clean cloth bag. Add purified water (6-8 times the weight of the herbs) to the bag and soak at room temperature for 8 hours to obtain a mixed herbal mixture.

[0109] 3) placing ginseng and placenta in corresponding external containers, adding purified water 8 times the weight of ginseng or placenta to the corresponding containers, soaking them at room temperature for 8 hours, and then decocting the ginseng and placenta separately once with a slow fire for 1 hour each, to obtain a first ginseng decoction and a first placenta decoction, which are then taken out for later use; adding purified water 8 times the weight of ginseng or placenta to the corresponding containers again, and decocting the ginseng and placenta separately once with a slow fire for 1 hour each, to obtain a second ginseng decoction and a second placenta decoction, which are then taken out for later use; combining the first ginseng decoction and the second ginseng decoction to obtain a ginseng medicinal liquid; combining the first placenta decoction and the second placenta decoction to obtain a placenta medicinal liquid, so as to facilitate subsequent combination with the total medicinal liquid;

[0110] 4) subjecting the Poria cocos to a vacuum freeze-drying treatment, wherein the Poria cocos is frozen and freeze-dried at a temperature of ≤-40° C. to obtain a freeze-dried Poria cocos product having a moisture content of less than 5 wt %, so as to improve the stability and efficacy of the paste prescription and prepare the freeze-dried Poria cocos product for later use;

[0111] 5) Based on the different solubilities of the solvents, the stir-fried spinach seeds are first subjected to heating reflux extraction using an ethanol-water solution having a volume ratio of water to ethanol of 70% by volume at 70-80° C., the reflux is repeated twice, and the stir-fried spinach seeds are subjected to reduced pressure concentration at 60° C. to remove the alcohol to obtain the fat-soluble tranquilizing component of the stir-fried spinach seeds; the stir-fried spinach seeds residue after the fat-soluble tranquilizing component is extracted is filtered and separated, and the stir-fried spinach seeds residue is thoroughly washed with purified water until no ethanol residue is left, and then the stir-fried spinach seeds residue is decocted with purified water 6-8 times the weight of the spinach seeds residue at normal pressure of 90±2° C. for 1.5 hours to obtain the water-soluble component of the stir-fried spinach seeds residue; the fat-soluble tranquilizing component and the water-soluble component are combined in a volume ratio of 1:3 to obtain a stir-fried spinach seeds extract for later use;

[0112] 6) Bag the cinnamon separately for later use;

[0113] 7) Crush the antler glue and place it in a 60-80°C water bath to dissolve into antler glue liquid. Then slowly add the antler glue liquid to the aforementioned mixed solution and stir thoroughly to mix.

[0114] 8) placing the mixed medicinal materials and the freeze-dried Poria cocos into a copper pot, adding purified water 6-8 times the weight of the combined weight of the mixed medicinal materials and the freeze-dried Poria cocos, and decocting once over low heat for 1.5 hours. After the decoction is completed, filtering through an 80-100 mesh sieve to obtain a first decoction; decocting the first decoction again over low heat for 1.5 hours, adding cinnamon 20 minutes before the end of the second decoction to prevent the cinnamon from volatilizing and losing its active ingredients due to prolonged decoction. After the decoction is completed, filtering through an 80-100 mesh sieve to obtain a decoction liquid;

[0115] 9) combining the decoction with the ginseng and placenta extracts and the stir-fried jujube seed extract to obtain a combined solution, filtering the combined solution 2-3 times through an 80-100 mesh sieve to obtain a filtrate, then slowly adding the antler glue solution to the filtrate and stirring to mix thoroughly, and then decocting the filtrate over a low heat at 70-80° C. During the decoction, adding melted honey in predetermined portions and stirring continuously to concentrate the paste into a bead-like or honeycomb-shaped paste, and finally collecting the paste when the paste is formed into beads or a flag-like consistency;

[0116] 10) While the paste is still hot, divide it into pre-sterilized glass bottles, sterilize the glass bottles with paste using high-pressure steam at 121°C for 20-30 minutes, seal and store after cooling, and implement quality management according to preset standards for long-term storage and clinical application.

[0117] Preferred formula 4, a heart-tonifying, kidney-benefiting and mind-soothing paste prescription, is composed of the following components in parts by weight: 25 parts of angelica sinensis, 25 parts of white peony root, 28 parts of cooked rehmannia, 19 parts of ginseng, 22 parts of white atractylodes, 9.5 parts of licorice, 28 parts of poria, 28 parts of astragalus, 8 parts of cinnamon, 12.5 parts of schisandra chinensis, 19 parts of polygala tenuifolia, 25 parts of poria, 25 parts of stir-fried jujube seeds, 12.5 parts of tangerine peel, 25 parts of salvia miltiorrhiza, 12.5 parts of placenta, 25 parts of coix seed, 8.1 parts of amomum villosum, 28 parts of ginger, and 180 parts of honey.

[0118] Example 4

[0119] The preparation of the Buxin Yishen Anshen ointment prescription of the present embodiment specifically comprises the following steps:

[0120] 1) According to the predetermined proportions, weigh 25 parts of Chinese Angelica sinensis, 25 parts of white peony root, 28 parts of Rehmannia glutinosa, 19 parts of ginseng, 22 parts of Atractylodes macrocephala, 9.5 parts of liquorice, 28 parts of Poria cocos, 28 parts of Astragalus membranaceus, 8 parts of cinnamon bark, 12.5 parts of Schisandra chinensis, 19 parts of Polygala tenuifolia, 25 parts of Poria cocos, 25 parts of stir-fried Ziziphus jujuba seeds, 12.5 parts of dried tangerine peel, 25 parts of Salvia miltiorrhiza, 12.5 parts of placenta, 25 parts of Coix seeds, 8.1 parts of Amomum villosum, 28 parts of ginger, and 180 parts of honey;

[0121] 2) Place the remaining herbs, except ginseng, placenta, poria, stir-fried jujube seeds, cinnamon, and honey, into a clean cloth bag. Add purified water (6-8 times the weight of the herbs) to the bag and soak at room temperature for 8 hours to obtain a mixed herbal mixture.

[0122] 3) placing ginseng and placenta in corresponding external containers, adding purified water 8 times the weight of ginseng or placenta to the corresponding containers, soaking them at room temperature for 8 hours, and then decocting the ginseng and placenta separately once with a slow fire for 1 hour each, to obtain a first ginseng decoction and a first placenta decoction, which are then taken out for later use; adding purified water 8 times the weight of ginseng or placenta to the corresponding containers again, and decocting the ginseng and placenta separately once with a slow fire for 1 hour each, to obtain a second ginseng decoction and a second placenta decoction, which are then taken out for later use; combining the first ginseng decoction and the second ginseng decoction to obtain a ginseng medicinal liquid; combining the first placenta decoction and the second placenta decoction to obtain a placenta medicinal liquid, so as to facilitate subsequent combination with the total medicinal liquid;

[0123] 4) subjecting the Poria cocos to a vacuum freeze-drying treatment, wherein the Poria cocos is frozen and freeze-dried at a temperature of ≤-40° C. to obtain a freeze-dried Poria cocos product having a moisture content of less than 5 wt %, so as to improve the stability and efficacy of the paste prescription and prepare the freeze-dried Poria cocos product for later use;

[0124] 5) Based on the different solubilities of the solvents, the stir-fried spinach seeds are first subjected to heating reflux extraction using an ethanol-water solution having a volume ratio of water to ethanol of 70% by volume at 70-80° C., the reflux is repeated twice, and the stir-fried spinach seeds are subjected to reduced pressure concentration at 60° C. to remove the alcohol to obtain the fat-soluble tranquilizing component of the stir-fried spinach seeds; the stir-fried spinach seeds residue after the fat-soluble tranquilizing component is extracted is filtered and separated, and the stir-fried spinach seeds residue is thoroughly washed with purified water until no ethanol residue is left, and then the stir-fried spinach seeds residue is decocted with purified water 6-8 times the weight of the spinach seeds residue at normal pressure of 90±2° C. for 1.5 hours to obtain the water-soluble component of the stir-fried spinach seeds residue; the fat-soluble tranquilizing component and the water-soluble component are combined in a volume ratio of 1:3 to obtain a stir-fried spinach seeds extract for later use;

[0125] 6) Bag the cinnamon separately for later use;

[0126] 7) Crush the antler glue and place it in a 60-80°C water bath to dissolve into antler glue liquid. Then slowly add the antler glue liquid to the aforementioned mixed solution and stir thoroughly to mix.

[0127] 8) placing the mixed medicinal materials and the freeze-dried Poria cocos into a copper pot, adding purified water 6-8 times the weight of the combined weight of the mixed medicinal materials and the freeze-dried Poria cocos, and decocting once over low heat for 1.5 hours. After the decoction is completed, filtering through an 80-100 mesh sieve to obtain a first decoction; decocting the first decoction again over low heat for 1.5 hours, adding cinnamon 20 minutes before the end of the second decoction to prevent the cinnamon from volatilizing and losing its active ingredients due to prolonged decoction. After the decoction is completed, filtering through an 80-100 mesh sieve to obtain a decoction liquid;

[0128] 9) combining the decoction with the ginseng and placenta extracts and the stir-fried jujube seed extract to obtain a combined solution, filtering the combined solution 2-3 times through an 80-100 mesh sieve to obtain a filtrate, then slowly adding the antler glue solution to the filtrate and stirring to mix thoroughly, and then decocting the filtrate over a low heat at 70-80° C. During the decoction, adding melted honey in predetermined portions and stirring continuously to concentrate the paste into a bead-like or honeycomb-shaped paste, and finally collecting the paste when the paste is formed into beads or a flag-like consistency;

[0129] 10) While the paste is still hot, divide it into pre-sterilized glass bottles, sterilize the glass bottles with paste using high-pressure steam at 121°C for 20-30 minutes, seal and store after cooling, and implement quality management according to preset standards for long-term storage and clinical application.

[0130] Preferred formula 5, a prescription for nourishing the heart, benefiting the kidneys and calming the mind, is composed of the following components in parts by weight: 30 parts of angelica sinensis, 30 parts of white peony root, 30 parts of cooked rehmannia, 20 parts of ginseng, 25 parts of white atractylodes, 10 parts of licorice, 30 parts of poria, 30 parts of astragalus, 10 parts of cinnamon, 15 parts of schisandra chinensis, 20 parts of polygala tenuifolia, 30 parts of poria, 30 parts of stir-fried jujube seeds, 15 parts of tangerine peel, 30 parts of salvia miltiorrhiza, 15 parts of placenta, 30 parts of coix seed, 10 parts of amomum villosum, 30 parts of ginger, 200 parts of honey, and 20 parts of antler glue.

[0131] Example 5

[0132] The preparation of the Buxin Yishen Anshen ointment prescription of the present embodiment specifically comprises the following steps:

[0133] 1) According to the predetermined ratio, weigh 30 parts of Chinese Angelica sinensis, 30 parts of white peony root, 30 parts of prepared rehmannia root, 20 parts of ginseng, 25 parts of white atractylodes, 10 parts of liquorice, 30 parts of poria, 30 parts of astragalus, 10 parts of cinnamon, 15 parts of schisandra chinensis, 20 parts of polygala tenuifolia, 30 parts of poria, 30 parts of stir-fried spinach seeds, 15 parts of dried tangerine peel, 30 parts of salvia miltiorrhiza, 15 parts of placenta, 30 parts of coix seed, 10 parts of amomum villosum, 30 parts of ginger, 200 parts of honey, and 20 parts of antler glue;

[0134] 2) Place the remaining herbs, except ginseng, placenta, poria, stir-fried jujube seeds, cinnamon, and honey, into a clean cloth bag. Add purified water (6-8 times the weight of the herbs) to the bag and soak at room temperature for 8 hours to obtain a mixed herbal mixture.

[0135] 3) placing ginseng and placenta in corresponding external containers, adding purified water 8 times the weight of ginseng or placenta to the corresponding containers, soaking them at room temperature for 8 hours, and then decocting the ginseng and placenta separately once with a slow fire for 1 hour each, to obtain a first ginseng decoction and a first placenta decoction, which are then taken out for later use; adding purified water 8 times the weight of ginseng or placenta to the corresponding containers again, and decocting the ginseng and placenta separately once with a slow fire for 1 hour each, to obtain a second ginseng decoction and a second placenta decoction, which are then taken out for later use; combining the first ginseng decoction and the second ginseng decoction to obtain a ginseng medicinal liquid; combining the first placenta decoction and the second placenta decoction to obtain a placenta medicinal liquid, so as to facilitate subsequent combination with the total medicinal liquid;

[0136] 4) subjecting the Poria cocos to a vacuum freeze-drying treatment, wherein the Poria cocos is frozen and freeze-dried at a temperature of ≤-40° C. to obtain a freeze-dried Poria cocos product having a moisture content of less than 5 wt %, so as to improve the stability and efficacy of the paste prescription and prepare the freeze-dried Poria cocos product for later use;

[0137] 5) Based on the different solubilities of the solvents, the stir-fried spinach seeds are first subjected to heating reflux extraction using an ethanol-water solution having a volume ratio of water to ethanol of 70% by volume at 70-80° C., the reflux is repeated twice, and the stir-fried spinach seeds are subjected to reduced pressure concentration at 60° C. to remove the alcohol to obtain the fat-soluble tranquilizing component of the stir-fried spinach seeds; the stir-fried spinach seeds residue after the fat-soluble tranquilizing component is extracted is filtered and separated, and the stir-fried spinach seeds residue is thoroughly washed with purified water until no ethanol residue is left, and then the stir-fried spinach seeds residue is decocted with purified water 6-8 times the weight of the spinach seeds residue at normal pressure of 90±2° C. for 1.5 hours to obtain the water-soluble component of the stir-fried spinach seeds residue; the fat-soluble tranquilizing component and the water-soluble component are combined in a volume ratio of 1:3 to obtain a stir-fried spinach seeds extract for later use;

[0138] 6) Bag the cinnamon separately for later use;

[0139] 7) Crush the antler glue and place it in a 60-80°C water bath to dissolve into antler glue liquid. Then slowly add the antler glue liquid to the aforementioned mixed solution and stir thoroughly to mix.

[0140] 8) placing the mixed medicinal materials and the freeze-dried Poria cocos into a copper pot, adding purified water 6-8 times the weight of the combined weight of the mixed medicinal materials and the freeze-dried Poria cocos, and decocting once over low heat for 1.5 hours. After the decoction is completed, filtering through an 80-100 mesh sieve to obtain a first decoction; decocting the first decoction again over low heat for 1.5 hours, adding cinnamon 20 minutes before the end of the second decoction to prevent the cinnamon from volatilizing and losing its active ingredients due to prolonged decoction. After the decoction is completed, filtering through an 80-100 mesh sieve to obtain a decoction liquid;

[0141] 9) combining the decoction with the ginseng and placenta extracts and the stir-fried jujube seed extract to obtain a combined solution, filtering the combined solution 2-3 times through an 80-100 mesh sieve to obtain a filtrate, then slowly adding the antler glue solution to the filtrate and stirring to mix thoroughly, and then decocting the filtrate over a low heat at 70-80° C. During the decoction, adding melted honey in predetermined portions and stirring continuously to concentrate the paste into a bead-like or honeycomb-shaped paste, and finally collecting the paste when the paste is formed into beads or a flag-like consistency;

[0142] 10) While the paste is still hot, divide it into pre-sterilized glass bottles, sterilize the glass bottles with paste using high-pressure steam at 121°C for 20-30 minutes, seal and store after cooling, and implement quality management according to preset standards for long-term storage and clinical application.

[0143] Typical Case 1

[0144] Intervention and effect of Buxin Yishen Anshen paste on insomnia model mice

[0145] 1 Materials and Methods

[0146] 1.1 Experimental Animals

[0147] Sixty healthy, SPF-grade, male C57BL / 6J mice (18 ± 2 g), aged 4-6 weeks, were housed at 24 ± 2°C and 50%-65% relative humidity. They were housed in cages with free access to food and water throughout the study, and maintained on a 12-hour light / dark cycle. The animals were acclimated for 7 days before the experiment. This study was approved by the Shenzhen Zhongxun Precision Medicine Research Institute.

[0148] 1.2 Investigational Drugs

[0149] The heart-tonifying, kidney-benefiting and mind-calming ointment of the present invention is prepared according to the method described in Example 2. Purified water is used to prepare a solution for administration.

[0150] Heart-tonifying, kidney-benefiting and tranquilizing paste: 20 parts of Chinese angelica, 20 parts of white peony root, 22.5 parts of cooked rehmannia, 15 parts of ginseng, 17.5 parts of white atractylodes, 7.5 parts of liquorice, 22.5 parts of poria, 22.5 parts of astragalus, 6.5 parts of cinnamon, 10 parts of schisandra, 15 parts of polygala, 20 parts of poria, 20 parts of stir-fried spiny jujube seeds, 10 parts of dried tangerine peel, 20 parts of salvia miltiorrhiza, 10 parts of placenta, 20 parts of coix seed, 6.5 parts of amomum, 20 parts of ginger, 150 parts of honey, 15 parts of antler glue.

[0151] Weigh the remaining herbs, except for ginseng, placenta, stir-fried jujube seeds, poria, cinnamon, and honey, in appropriate proportions. Place them in a clean cloth bag and soak for 8 hours in purified water, 6-8 times the weight of the herbs in this step. Extract the stir-fried jujube seeds separately with 70% alcohol and then with water. After soaking, decoct the herbs twice. Add cinnamon 20 minutes before the end of the second decoction. Soak the ginseng and placenta separately and decoct them twice. Combine all the liquids and filter through an 80- to 100-mesh sieve three times. Concentrate to a clear, honeycomb-like paste. Reduce heat and add the melted honey to dissolve the paste. Prepare the solution with purified water for administration.

[0152] 1.3 Grouping and modeling

[0153] Ten mice were randomly selected as the normal group, and the rest were model groups. The mice were randomly divided into the following five groups, with 10 mice in each group: model group, diazepam group, low-dose Buxin Yishen Anshen Paste group, medium-dose Buxin Yishen Anshen Paste group, and high-dose Buxin Yishen Anshen Paste group.

[0154] This study used a modified chlorophenylalanine combined with chronic unpredictable mild stress model to establish an insomnia mouse model. Adaptive feeding was performed for 7 days. After the adaptation period, starting on the 8th day, all model group mice were exposed to chronic unpredictable mild stress stimulation for 6 weeks. One of the following stimulation methods was performed daily, including forced swimming, wet bedding, food and water deprivation, strong light stroboscopic stimulation, and light-dark reversal cycle. Starting from the 49th day, except for the normal group, all groups of mice were intraperitoneally injected with PCPA (350 mg / kg) every morning for 3 consecutive days. The normal group of mice was placed in the home cage and raised normally to ensure adequate sleep conditions. During the modeling period, all rats had free access to basic feed and distilled water. When the model mice showed typical characteristics such as curling up, lack of security, listlessness, withered fur, reduced food and water intake, and obvious stress response when grasping, it indicated that the model was successful.

[0155] 1.4 Administration

[0156] On the 52nd day, the mice in the low-dose Buxin Yishen Anshen Paste group, the medium-dose Buxin Yishen Anshen Paste group, the high-dose Buxin Yishen Anshen Paste group, and the diazepam group were given medication according to the designated doses for 7 days, and the control group and the model group received an equal amount of normal saline by gavage.

[0157] 1.5 Behavioral testing

[0158] (1) Righting experiment

[0159] After modeling, mice in each group were intraperitoneally injected with 30 mg / kg sodium pentobarbital. Mice were placed on a flat surface with their abdomen facing upward and their bodies held vertically. The time from the time of intraperitoneal injection to the loss of the righting reflex was considered sleep latency. If the mouse turned over more than twice within 60 seconds, the righting reflex was considered recovered. The time from the loss of the righting reflex to the recovery of the righting reflex was considered sleep duration.

[0160] (2 Open field experiment

[0161] Place the mouse in the center square of an open box (the size of the open box is 100 cm long x 100 cm wide x 40 cm high), use a counter to manually count the number of squares each mouse crosses horizontally within 5 minutes, record the time and number of times the mouse enters the central area, and calculate the total distance the mouse travels.

[0162] (3) New object recognition experiment

[0163] Two objects, A and B, of different shapes and colors, were placed in a chamber, 25 cm apart. On the first day, mice were allowed to acclimate to the chamber for 20 minutes. The two objects were identical (both objects were A). One hour later, object A on the left side was replaced with object B, and the time the mice spent in contact with A and B within a 5-minute period was recorded. After 24 hours, object A on the right side was replaced with object B, and the time the mice spent in contact with A and B within a 5-minute period was recorded.

[0164] 1.6 Statistical methods

[0165] SPSS 23.0 statistical software was used for data processing, and one-way analysis of variance was used to compare data among the groups. P < 0.05 was considered statistically significant.

[0166] 2 Results

[0167] 2.1 Results of the Reversal Experiment

[0168] like Figure 1 The results of the reversal experiment showed that compared with the control group, the sleep latency of the mice in the model group was prolonged and the sleep time was shortened, and the differences were statistically significant (P < 0.05). After taking the medicine, the latency of the mice in the low-dose Buxin Yishen Anshen Paste group, the medium-dose Buxin Yishen Anshen Paste group, the high-dose Buxin Yishen Anshen Paste group, and the diazepam group was significantly shortened, and the differences were statistically significant (P < 0.05); the latency of the mice in the low-dose Buxin Yishen Anshen Paste group, the medium-dose Buxin Yishen Anshen Paste group, the high-dose Buxin Yishen Anshen Paste group, and the diazepam group was significantly prolonged, and the differences were statistically significant (P < 0.05). This shows that Buxin Yishen Anshen Paste has a significant effect on improving sleep disorders in mice.

[0169] 2.2 Open field test results

[0170] like Figures 2 to 5 Results of movement trajectories showed that the total distance traveled, the number of entries into the central area, and the duration of stay in the model group were significantly reduced compared with the control group (P < 0.05). The total distance traveled by mice in the medium-dose, high-dose, and diazepam groups increased significantly (P < 0.05). The number of entries into the central area increased significantly in the low-dose, medium-dose, and high-dose groups compared with the model group (P < 0.05). The duration of stay in the central area increased significantly in the low-dose, medium-dose, and high-dose groups compared with the model group (P < 0.05). This suggests that the medium-dose, high-dose, and high-dose groups of Buxin Yishen Anshen Paste can alleviate anxiety-like behaviors and improve the exploratory ability and emotional stability of mice, with the medium- and high-dose interventions being particularly effective.

[0171] 2.3 Experimental results of new object recognition

[0172] like Figure 6 The results of the novel object recognition experiment showed that the novel object recognition index of the model group mice was significantly lower than that of the control group (P < 0.05), while the novel object recognition index of the low-dose Buxin Yishen Anshen Paste group, the medium-dose Buxin Yishen Anshen Paste group, the high-dose Buxin Yishen Anshen Paste group, and the diazepam group increased with statistical significance (P < 0.05). This suggests that Buxin Yishen Anshen Paste has the potential to improve cognitive function and enhance learning and memory abilities, possibly by regulating central nervous system function.

[0173] In summary, the present invention provides a heart-tonifying, kidney-benefiting and mind-calming ointment prescription, which has the following effects and advantages:

[0174] 1. The paste formula is unique in its effectiveness: Ginseng, Astragalus, and Atractylodes macrocephala are used as the main herbs to strengthen the spleen and replenish vital energy. The auxiliary herbs are carefully formulated, including Angelica sinensis and White Peony Root to replenish blood, Rehmannia glutinosa and Placenta to replenish the kidney and essence, and Cinnamon bark to warm and strengthen the primordial Yang and guide the fire back to the source, nourishing the heart blood and benefiting the kidney essence, subduing the deficiency fire and calming the mind. Poria cocos, Coix seed, Amomum villosum, and Tangerine peel regulate Qi and eliminate dampness, preventing essence and blood supplements from overly hindering the spleen and stagnate it, nourishing without stagnation. Salvia miltiorrhiza is used to activate blood circulation and unblock the heart meridians, Ziziphus jujuba seeds to nourish the heart and calm the mind, Polygala tenuifolia and Poria cocos to calm the heart and palpitations, and Schisandra chinensis to suppress yang and calm the mind. Roasted licorice harmonizes the herbs, while honey moisturizes, corrects the flavor, helps the paste form, and harmonizes the medicinal properties. The whole formula works synergistically through multiple targets, including replenishing vital energy, nourishing blood and tonifying the kidneys, calming the mind, and strengthening the spleen and eliminating dampness. It targets the pathogenesis of insomnia caused by deficiency of the heart, spleen, and kidneys, and malnutrition of the mind, and can effectively improve symptoms such as difficulty falling asleep, shallow sleep and easy awakening, frequent dreams, palpitations, shortness of breath, tinnitus, and forgetfulness.

[0175] 2. Animal experiments show that the heart-tonifying, kidney-benefiting and tranquilizing ointment of the present invention has the effects of significantly shortening the time to fall asleep, prolonging sleep duration, improving cognitive function, improving anxiety symptoms, and relieving fatigue in insomnia mice, and the effect is remarkable. It is precisely because the present invention treats the heart, spleen, and kidneys simultaneously to meet the long-term conditioning needs of modern chronic insomnia with complex pathogenesis, sub-health and physical weakness people, that the heart-tonifying, kidney-benefiting and tranquilizing ointment of the present invention has the effects of significantly shortening the time to fall asleep, prolonging sleep duration, improving cognitive function, improving anxiety symptoms, and relieving fatigue in insomnia mice.

[0176] 3. The paste formula of the present invention is highly safe, has no toxic side effects, is easy to take, does not require decocting, is easy to store and carry, is suitable for long-term use, and has the effect of conditioning the body.

[0177] In summary, the present invention adopts the above formula, which has the advantage of treating the heart, spleen and kidney simultaneously to meet the comprehensive conditioning needs of modern chronic insomnia with complex pathogenesis, sub-health and weak people.

[0178] The above describes the preferred embodiments of the present invention. It should be understood that the present invention is not limited to the above-mentioned specific embodiments, and the devices and structures that are not described in detail should be understood to be implemented in a common manner in the art; any technician familiar with the art can use the above-mentioned disclosed methods and technical contents to make many possible changes and modifications to the technical solutions of the present invention without departing from the scope of the technical solutions of the present invention, or modify them into equivalent embodiments of equivalent changes, which does not affect the essential content of the present invention. Therefore, any simple modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention that do not depart from the content of the technical solutions of the present invention are still within the scope of protection of the technical solutions of the present invention.

Claims

1. A prescription for nourishing the heart, replenishing the kidneys and calming the mind, characterized by: The invention is composed of the following components in parts by weight: 10-30 parts of angelica sinensis, 10-30 parts of white peony root, 15-30 parts of cooked rehmannia root, 10-20 parts of ginseng, 10-25 parts of white atractylodes, 5-10 parts of liquorice, 15-30 parts of poria, 15-30 parts of astragalus, 3-10 parts of cinnamon, 5-15 parts of schisandra chinensis, 10-20 parts of polygala tenuifolia, 10-30 parts of poria, 10-30 parts of stir-fried spinach seeds, 5-15 parts of tangerine peel, 10-30 parts of salvia miltiorrhiza, 5-15 parts of placenta, 10-30 parts of coix seed, 3-10 parts of amomum villosum, 10-30 parts of ginger, 100-200 parts of honey and 10-20 parts of antler glue.

2. The heart-tonifying, kidney-benefiting and mind-calming ointment prescription according to claim 1, characterized in that: 10 parts of Chinese Angelica sinensis, 10 parts of white peony root, 15 parts of Rehmannia glutinosa, 10 parts of ginseng, 10 parts of Atractylodes macrocephala, 5 parts of liquorice, 15 parts of Poria cocos, 15 parts of Astragalus membranaceus, 3 parts of cinnamon bark, 5 parts of Schisandra chinensis, 10 parts of Polygala tenuifolia, 10 parts of Poria, 10 parts of stir-fried Ziziphus jujuba seeds, 5 parts of dried tangerine peel, 10 parts of Salvia miltiorrhiza, 5 parts of Placenta centifolia, 10 parts of Coix seed, 3 parts of Amomum villosum, 10 parts of ginger, 100 parts of honey, and 10 parts of antler glue.

3. The heart-tonifying, kidney-benefiting and mind-calming ointment prescription according to claim 1, characterized in that: The invention is composed of the following components in parts by weight: 20 parts of angelica sinensis, 20 parts of white peony root, 22.5 parts of cooked rehmannia root, 15 parts of ginseng, 17.5 parts of atractylodes macrocephala, 7.5 parts of liquorice, 22.5 parts of poria, 22.5 parts of astragalus, 6.5 parts of cinnamon bark, 10 parts of schisandra chinensis, 15 parts of polygala tenuifolia, 20 parts of poria, 20 parts of stir-fried spinach seeds, 10 parts of dried tangerine peel, 20 parts of salvia miltiorrhiza, 10 parts of placenta, 20 parts of coix seed, 6.5 parts of amomum villosum, 20 parts of ginger, 150 parts of honey and 15 parts of antler glue.

4. The heart-tonifying, kidney-benefiting and mind-calming ointment prescription according to claim 1, characterized in that: 30 parts of Chinese Angelica sinensis, 30 parts of white peony root, 30 parts of Rehmannia glutinosa, 20 parts of ginseng, 25 parts of Atractylodes macrocephala, 10 parts of liquorice, 30 parts of Poria cocos, 30 parts of Astragalus membranaceus, 10 parts of cinnamon bark, 15 parts of Schisandra chinensis, 20 parts of Polygala tenuifolia, 30 parts of Poria, 30 parts of stir-fried Ziziphus jujuba seeds, 15 parts of dried tangerine peel, 30 parts of Salvia miltiorrhiza, 15 parts of placenta, 30 parts of Coix seeds, 10 parts of Amomum villosum, 30 parts of ginger, 200 parts of honey, and 20 parts of antler glue.

5. A method for preparing the heart-tonifying, kidney-benefiting and mind-calming ointment according to any one of claims 1 to 4, characterized in that: The preparation method comprises the following steps: S1. According to the predetermined ratio, weigh the predetermined amount of angelica, white peony root, prepared rehmannia, white atractylodes, liquorice, poria, astragalus, schisandra, polygala, poria, tangerine peel, salvia miltiorrhiza, coix seed, and amomum villosum respectively, put them into a clean cloth bag and soak them in purified water 6-8 times the weight of the medicinal materials in this step for 7-9 hours; S2. Weigh predetermined amounts of ginseng and placenta, respectively, and place them in corresponding external containers. Add purified water 7-9 times the weight of the ginseng or placenta to the corresponding containers, respectively, and soak them at room temperature for 7-9 hours. Then, decoct the ginseng and placenta separately twice within a predetermined time using a slow fire to obtain ginseng and placenta medicinal solutions for later use. S3, weighing a predetermined amount of Poria cocos, and subjecting the Poria cocos to a vacuum freeze-drying treatment, wherein the Poria cocos is frozen and freeze-dried at a temperature of ≤-40° C. to obtain a freeze-dried Poria cocos product, wherein the moisture content of the freeze-dried Poria cocos product is less than 5 wt %; S4. Weighing a predetermined amount of stir-fried Chinese jujube seeds, and extracting the effective components of the Chinese jujube seeds using a predetermined alcohol extraction-water extraction combined process to obtain a stir-fried Chinese jujube seed extract containing fat-soluble tranquilizing components and water-soluble components for later use; S5. Weigh a predetermined amount of cinnamon and pack it in a separate bag for later use; S6. After crushing the antler glue, place it in a water bath at 60-80°C and melt it until it dissolves into antler glue liquid; S7, putting the soaked mixed medicinal materials of step S1 and the freeze-dried Poria cocos of step S3 into a copper pot together, and adding purified water 6-8 times the weight of the sum of the mixed medicinal materials in step S1 and the freeze-dried Poria cocos slices in step S3, decocting twice over a predetermined time with a slow fire, and adding the cinnamon of step S5 20 minutes before the end of the second decoction to avoid the cinnamon decoction time being too long and causing the active ingredient to volatilize and lose, and filtering with an 80-100 mesh sieve after each decoction to obtain a decoction liquid; S8, combining the decoction of step S7 with the ginseng and placenta medicinal liquids of step S2 and the stir-fried jujube seed extract of step S4 to obtain a combined medicinal liquid, filtering the combined medicinal liquid 2-3 times with an 80-100 mesh sieve to obtain a medicinal liquid filtrate, then slowly adding the antler glue of step S6 to the filtrate and stirring to mix, then decocting the medicinal liquid filtrate over a low heat of 70-80° C., adding melted honey in predetermined times during the decoction and continuously stirring to condense the paste into a beaded or honeycomb-shaped paste; S9. While the paste is still hot, divide it into pre-sterilized glass bottles, and then use high-pressure steam at 115℃-125℃ to sterilize the glass bottles containing the paste for 20-30 minutes. After cooling, seal and store them, and implement quality management according to preset standards to facilitate long-term storage and clinical application.

6. The preparation method according to claim 5, characterized in that: In step S2, the preparation of the ginseng medicinal solution and the placenta medicinal solution includes the following steps: S2.

1. Weigh a predetermined amount of ginseng and placenta, respectively, and place them in corresponding external containers. Add 8 times the weight of ginseng or placenta to the corresponding containers in purified water, soak them at room temperature for 8 hours, and then simmer the ginseng and placenta separately for 1 hour each to obtain the first ginseng decoction and the first placenta decoction, which are then taken out for later use. S2.2, again to the corresponding container were added ginseng or placenta 8 times the weight of pure water, again using a slow fire for ginseng and placenta were decocted again, the decoction time was 1 hour each, to obtain the second ginseng decoction and the second placenta decoction and take out for later use; S2.

3. Combine the first ginseng decoction of step S2.1 and the second ginseng decoction of step S2.2 to obtain ginseng medicinal liquid; combine the first placenta decoction of step S2.1 and the second placenta decoction of step S2.2 to obtain placenta medicinal liquid, so as to facilitate subsequent combination with the total medicinal liquid.

7. The preparation method according to claim 5, characterized in that: In step S4, the preparation of the stir-fried spinach seed extract comprises the following steps: S4.

1. Weigh a predetermined amount of stir-fried Chinese jujube seeds and extract their components using a combined alcohol-water extraction process. Specifically, based on the solubility of the solvents, first extract the stir-fried Chinese jujube seeds by heating and refluxing at 70-80°C with an ethanol-water solution having a volume ratio of 70% water to ethanol, with the stir-fried Chinese jujube seeds and ethanol-water solution being in a weight ratio of 1:8-10. Reflux for 2 hours, repeating twice, and then concentrating under reduced pressure at 55-65°C to remove the alcohol to obtain the fat-soluble tranquilizing component of the stir-fried Chinese jujube seeds. S4.

2. After extracting the fat-soluble tranquilizing component, the stir-fried Ziziphus jujuba seed residue is filtered and washed thoroughly with purified water until no ethanol residue remains. The stir-fried Ziziphus jujuba seed residue is then boiled in purified water (6-8 times the weight of the Ziziphus jujuba seed residue) at normal pressure and 90±2°C for 1.5 hours to obtain the water-soluble component of the stir-fried Ziziphus jujuba seed residue. S4.

3. Combine the fat-soluble sedative component of step S4.1 and the water-soluble component of step S4.2 at a volume ratio of 1:3 to obtain a stir-fried jujube seed extract.

8. The preparation method according to claim 5, characterized in that: In step S7, the preparation of the decoction comprises the following steps: S7.

1. Place the soaked mixed medicinal materials from step S1 and the freeze-dried Poria cocos from step S3 into a copper pot, add purified water 6-8 times the weight of the combined mixed medicinal materials from step S1 and the freeze-dried Poria cocos from step S3, and simmer once for 1.5 hours. After simmering, filter through an 80-100 mesh sieve to obtain a first decoction. S7.

2. The first decoction is decocted again over low heat for 1.5 hours. The cinnamon bark from step S5 is added 20 minutes before the end of the second decoction to prevent the cinnamon bark from volatilizing and losing its active ingredients due to prolonged decoction. After the decoction is completed, the decoction is filtered through an 80-100 mesh sieve to obtain the decoction.

Images