Traditional Chinese medicine preparation for treating varicella-zoster virus infection

Abstract

The invention discloses a traditional Chinese medicine preparation for treating varicella-herpes zoster virus infection. The traditional Chinese medicine preparation comprises the following components in parts by weight: 10-20 parts of ginseng, 9-15 parts of parasitic loranthus, 4-6 parts of schisandra chinensis, 6-9 parts of gastrodia elata, 6-9 parts of cassia twig, 6-9 parts of divaricate saposhnikovia root, 3-4.5 parts of prepared fructus evodiae, 10-20 parts of salvia miltiorrhiza, 8-12 parts of cortex moutan, 6-9 parts of radix paeoniae rubra, 6-9 parts of angelica sinensis, 6-9 parts of ligusticum wallichii, 1-5 parts of scorpion, 1-5 parts of centipede, 9-15 parts of pyrola, 6-9 parts of pericarpium citri reticulatae, 6-9 parts of rhizoma pinellinae praeparata and 6-9 parts of The traditional Chinese medicine preparation has the effects of strengthening the body resistance to eliminate pathogenic factors, dispelling cold to relieve convulsion, activating meridians to stop pain, detoxifying and resolving dampness, the curative effect of treating herpes zoster is satisfactory, and the incidence rate of postherpetic neuralgia is low.

Description

Technical Field

[0001] The invention relates to a traditional Chinese medicine preparation for treating varicella-zoster virus infection, belonging to the technical field of traditional Chinese medicines. Background Art

[0002] Herpes zoster (shingles) is a common dermatological disease caused by the varicella-zoster virus. The global incidence of herpes zoster is 3-5 per 1,000 people per year in the general population and 3-10 per 1,000 people per year in the Asia-Pacific region, with an annual increase of 2.5% to 5.0%. The typical symptom is the development of vesicles along sensory nerves in the corresponding innervated segments. Clinically, the rash is characterized by clusters of erythematous papules and blisters. Most patients experience severe pain during the acute phase and are prone to postherpetic neuralgia. Some patients even experience anxiety and depression, which can severely impact their daily lives. Current Western medical treatments primarily focus on antiviral, analgesic, and immune-boosting therapies. Antiviral drugs primarily include the commonly used open-ring nucleoside drugs (valacyclovir, acyclovir, famciclovir, etc.), interferons, and non-nucleoside drugs (sodium foscarnet, adenosine monophosphate, etc.). These drugs work by binding to the DNA polymerase of the varicella-zoster virus, reducing viral activity and exerting an antiviral effect. However, their clinical efficacy is less than satisfactory and they are associated with certain side effects. Traditional Chinese medicine (TCM) has some experience in treating herpes zoster. The current mainstream consensus in TCM circles is that the primary etiology of herpes zoster is damp-heat in the liver and gallbladder, spleen dysfunction, blocked collaterals, liver depression and qi stagnation, emotional disturbances, and dietary irregularities. However, a widely used and effective TCM preparation remains lacking in terms of therapeutic efficacy. Summary of the Invention

[0003] The present invention overcomes the drawbacks of the prior art and provides a traditional Chinese medicine preparation for treating varicella-zoster virus infection. The traditional Chinese medicine preparation has a high efficacy in treating herpes zoster, can quickly relieve the patient's pain, shorten the scab formation time, and significantly reduce the incidence of postherpetic neuralgia.

[0004] The technical solution adopted by the present invention to solve the above technical problems is: A traditional Chinese medicine preparation for treating varicella-zoster virus infection, comprising: 10-20 parts of ginseng, 9-15 parts of mistletoe, 4-6 parts of schisandra chinensis, 6-9 parts of gastrodia elata, 6-9 parts of cinnamon twig, 6-9 parts of siler, 3-4.5 parts of processed evodia rutaecarpa, 10-20 parts of salvia miltiorrhiza, 8-12 parts of moutan bark, 6-9 parts of red peony root, 1-5 parts of scorpion, 1-5 parts of centipede, 9-15 parts of leucanthemum, 6-9 parts of dried tangerine peel, 6-9 parts of pinellia, and 6-9 parts of roasted liquorice.

[0005] The above-mentioned traditional Chinese medicine preparation for treating varicella-zoster virus infection is characterized in that: the traditional Chinese medicine preparation further comprises the following components in parts by weight: 6-9 parts of angelica sinensis and 6-9 parts of ligusticum chuanxiong.

[0006] The above-mentioned traditional Chinese medicine preparation for treating varicella-zoster virus infection is calculated by weight as follows: 12-18 parts of ginseng, 10-14 parts of mistletoe, 4-6 parts of schisandra chinensis, 7-9 parts of gastrodia elata, 7-9 parts of cinnamon twig, 7-9 parts of siler, 3.5-4.5 parts of processed evodia rutaecarpa, 12-18 parts of salvia miltiorrhiza, 9-11 parts of moutan bark, 7-9 parts of red peony root, 7-9 parts of angelica, 7-9 parts of ligusticum, 7-9 parts of chuanxiong, 2-4 parts of scorpion, 2-4 parts of centipede, 10-14 parts of leucanthemum, 7-9 parts of dried tangerine peel, 7-9 parts of pinellia, and 7-9 parts of roasted liquorice.

[0007] The above-mentioned traditional Chinese medicine preparation for treating varicella-zoster virus infection is calculated by weight as follows: 15 parts of Radix Ginseng, 12 parts of Herba Mori Parasitici, 5 parts of Fructus Schisandrae Chinensis, 8 parts of Rhizoma Gastrodiae, 8 parts of Twig of Cinnamomum Cinnamomum, 8 parts of Radix Saposhnikoviae, 4 parts of Processed Fructus Evodiae, 15 parts of Radix Salviae Miltiorrhizae, 10 parts of Cortex Moutan, 8 parts of Radix Paeoniae Rubra, 8 parts of Radix Angelicae Sinensis, 8 parts of Rhizoma Chuanxiong, 3 parts of Scorpio, 3 parts of Scolopendra, 12 parts of Herba Deerebi, 8 parts of Pericarpium Citri Reticulatae, 8 parts of Rhizoma Pinelliae, and 8 parts of Radix Glycyrrhizae Preparata.

[0008] The common pharmacological effects of the Chinese medicinal raw materials selected in the present invention are as follows: Ginseng: Sweet, slightly bitter, and warm in nature. It enters the spleen and lung meridians. It significantly replenishes vital energy, benefits the lungs and spleen, promotes the production of body fluids and nourishes the blood, and calms the mind. It is used for conditions such as physical weakness, shortness of breath, spontaneous sweating, cold limbs, mental fatigue, and any deficiency of qi, blood, and body fluids. Ginseng has anti-shock and cardiotonic effects; it also fights fatigue, promotes protein, DNA, and RNA synthesis, and boosts the hematopoietic system; it can enhance the immune system. It also has anti-inflammatory and anti-allergic properties.

[0009] Mulberry parasite: Bitter and sweet in flavor, neutral in nature. Enters the liver and kidney meridians. It nourishes the liver and kidneys, strengthens the bones and tendons, dispels rheumatism, lowers blood pressure, and promotes lactation and pregnancy. It is used to treat rheumatic pain, soreness of the waist and knees, and weakness in the bones and tendons. It has a significant inhibitory effect on poliovirus and other enteroviruses, and inhibits the growth of Salmonella typhi and Staphylococcus aureus.

[0010] Schisandra chinensis: Sour and warm in nature. It enters the lung, kidney, and heart meridians. It has astringent and firming properties, replenishes Qi and promotes fluid production, and nourishes the kidneys and calms the mind. It promotes bile secretion, lowers serum transaminases, and protects liver cells. It also has antihypertensive, immune-enhancing, antioxidant, anti-aging, and antibacterial properties.

[0011] Gastrodia elata: Sweet in flavor, slightly warm in nature. It enters the Liver Meridian. It calms the liver, calms wind, relieves spasms, and relieves pain. Studies have shown that Gastrodia elata has analgesic and anti-inflammatory effects, and its polysaccharides have immunomodulatory properties.

[0012] Processed Evodia rutaecarpa: Pungent, bitter, and warm in nature. It enters the liver, spleen, and stomach meridians. It warms the middle and dispels cold, soothes the liver, and relieves pain. Processed Evodia rutaecarpa also has analgesic and antiemetic effects; it lowers blood pressure; and has antiplatelet and antithrombotic properties.

[0013] Cinnamon twig: Pungent and sweet in flavor, warm in nature. It enters the Heart, Lung, and Bladder meridians. It promotes diaphoresis, warms the meridians and dredges the collaterals, and promotes yang and transforms qi. It is used to treat the symptoms of colds caused by wind and cold, cold pain in the abdomen and stomach, amenorrhea due to blood cold, soreness and pain in the shoulders, back, and joints, chest pain due to phlegm and fluid retention, edema, and palpitations. Its decoction and cinnamaldehyde have cooling and antipyretic effects. The decoction and ethanol extract have antibacterial and antiviral properties. Cinnamaldehyde also has analgesic, sedative, and anticonvulsant properties.

[0014] Saposhnikovia root: Sweet, pungent, and warm in nature. It enters the bladder, liver, and spleen meridians. It has the functions of dispelling wind, removing dampness, and dispelling wind. It is used for colds, headaches, fever, analgesia, and rheumatic pain. It has antipyretic, anti-inflammatory, analgesic, sedative, anticonvulsant, anti-allergic, and anti-pathogenic effects, and can enhance the phagocytic function of macrophages.

[0015] Salvia miltiorrhiza: Bitter in flavor and cold in nature. It enters the Heart, Pericardium, and Liver meridians. It promotes blood circulation, dissipates stasis, reduces swelling and relieves pain, nourishes blood, and calms the mind. It is used for chest, abdominal, or limb pain caused by blood stasis, carbuncles, sores, restlessness, and insomnia. It improves microcirculation and blood flow; it also has sedative, analgesic, anti-inflammatory, antibacterial, and anti-allergic properties.

[0016] Angelica sinensis: Sweet and pungent in flavor, warm in nature. It enters the liver, heart, and spleen meridians. It nourishes and invigorates blood circulation, regulates menstruation and relieves pain, and moistens the intestines and promotes bowel movements. It is used for sallow complexion caused by blood deficiency, dizziness and palpitations, abdominal pain due to cold deficiency, constipation caused by dry intestines, rheumatic pain, and carbuncles and ulcers.

[0017] Chuanxiong: Spicy, slightly bitter, and warm in nature. It enters the Liver, Gallbladder, and Pericardium meridians. It promotes blood circulation and qi, dispels wind, and relieves pain. It is used to treat headaches, chest and flank pain, sores, swelling, and rheumatic pain. It has sedative, antibacterial, and antihistamine properties.

[0018] Red Peony Root: Bitter in flavor, slightly cold in nature. It enters the Liver Meridian. It promotes blood circulation, dissipates blood stasis, clears heat, and cools the blood. It is used to treat chest and flank pain, abdominal pain, and carbuncles. It improves blood rheology and microcirculation, and inhibits platelet aggregation. It also has analgesic and anticonvulsant properties.

[0019] Moutan Bark: Bitter and pungent in flavor, slightly cold in nature. It enters the Heart, Liver, and Kidney meridians. It clears heat and cools blood, promotes blood circulation and dissipates blood stasis, and relieves pain. It is used for fever-induced rashes, stagnant Qi and blood, and carbuncles, sores, and ulcers. It has anti-inflammatory properties, analgesic, sedative, anticonvulsant, and antipyretic effects, as well as free radical scavenging and immune-modulating properties.

[0020] Scorpion: Pungent in flavor, neutral in nature. Enters the Liver Meridian. Effective for calming wind and relieving spasms, detoxifying and dispersing stagnation, unblocking meridians and relieving pain. Used for rheumatic arthritis, migraines, sores, and scrofula. This product has significant anticonvulsant, anticoagulant, and analgesic effects.

[0021] Centipede: Salty, pungent, and warm in flavor. It enters the Liver Meridian. It calms wind and spasms, detoxifies and resolves stagnation, and relieves pain. It is used for rheumatism, sores, and scrofula.

[0022] Deerbill Herb: Sweet and bitter in flavor, warm in nature. It enters the liver, kidney, and lung meridians. It dispels rheumatism, strengthens bones and tendons, and stops bleeding. It is used for rheumatic pain and weakness in the waist and knees. It has anti-inflammatory properties, increases blood flow, and enhances immune function; it also has inhibitory effects on various bacteria. Clinically, selected prescriptions are used for rheumatic arthritis.

[0023] Tangerine peel: Bitter, pungent, and warm in nature. It enters the spleen and lung meridians. It regulates qi, strengthens the spleen, eliminates dampness, and resolves phlegm. It is used to treat chest and abdominal distension, belching, vomiting, loss of appetite, and cough with sputum. It has a certain inhibitory effect on bacteria such as Staphylococcus aureus and Proteus.

[0024] Pinellia ternata (French Pinellia): Pungent in flavor and warm in nature. It enters the spleen, stomach, and lung meridians. It has the functions of drying dampness and resolving phlegm, relieving nausea and vomiting, and dissolving lumps and knots. It is used for cough and wheezing caused by phlegm and fluid, cough and shortness of breath, chest and abdominal distension, nausea and vomiting, dizziness, and carbuncles.

[0025] Roasted Licorice: Sweet and neutral in nature. It enters the Heart, Lung, Spleen, and Stomach meridians. It tonifies the spleen and replenishes Qi, relieves coughs, resolves phlegm, clears away heat and detoxifies, relieves urgency and pain, and harmonizes the properties of drugs. It is used for spleen and stomach deficiency, insufficient Qi, cough and shortness of breath, carbuncles, acute abdominal cramps, hysteria, and to mitigate the effects of potent drugs and detoxify. It relieves smooth muscle spasms and provides analgesia; it also has antibacterial, antiviral, anti-inflammatory, and anti-allergic properties; and it has anti-diuretic, lipid-lowering, hepatoprotective, and detoxifying properties. Beneficial effects

[0026] The Chinese medicine preparation of the present invention uses ginseng, mistletoe, schisandra chinensis, and gastrodia elata as main medicines to strengthen the body constitution, nourish the spleen and lungs, and strengthen the body's resistance and eliminate pathogenic factors; auxiliary medicines include cassia twig, siler, and processed evodia rutaecarpa to nourish the liver and kidney yang, warm the meridians and dispel cold and relieve pain; auxiliary medicines include ligusticum chuanxiong, salvia miltiorrhiza, angelica, moutan bark, red peony root, scorpion, and centipede to promote blood circulation and qi circulation, dispel blood stasis, detoxify and resolve stagnation, dredge the meridians and stop spasms, and achieve smooth meridians and relieve pain; additionally, tangerine peel, pinellia tuber, and herba scutellariae are used as auxiliary medicines to regulate qi and regulate the middle qi, dispel dampness and resolve phlegm, with pinellia tuber being the main medicine for treating phlegm and dampness; and roasted liquorice root to invigorate qi and strengthen the spleen and harmonize the other medicines. The combination of the various medicines has a synergistic effect, and has the effects of strengthening the body's resistance and eliminating pathogenic factors, dispelling cold and relieving spasms, dredge the meridians and stop pain, and detoxify and resolve dampness. The prescription of the present invention has a high efficacy in treating herpes zoster, can quickly relieve the patient's pain, shortening the pain relief time to about 4 days, shortening the scab formation time to about 7 days, and significantly reducing the incidence of postherpetic neuralgia. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 This is a comparison chart of case 1 in the observation group before and after 7 days of treatment; Figure 2 This is a comparison chart of case 2 in the observation group before and after 7 days of treatment; Figure 3 This is a comparison chart of case 3 in the observation group before and after 7 days of treatment; Figure 4 This is a comparison chart of case 4 in the observation group before and after 7 days of treatment; Figure 5 This is a comparison chart of case 5 in the observation group before and after 7 days of treatment; Figure 6 This is a comparison chart of case 6 in the observation group before and after 7 days of treatment; The left picture is before treatment; the right picture is after treatment. DETAILED DESCRIPTION

[0028] The traditional Chinese medicine syndrome differentiation of herpes zoster mainly includes liver-gallbladder damp-heat type, spleen dysfunction type, qi stagnation and blood stasis type, and the treatment strategy focuses on clearing away heat and toxic substances, invigorating the spleen and removing dampness, promoting blood circulation and removing blood stasis, promoting qi circulation and removing stagnation, and relieving pain. The present invention considers that herpes zoster is common in middle-aged and elderly people and people with physical weakness. Such patients are liver-kidney insufficiency, old and weak, and lack of vital energy, which leads to the internal release of latent pathogens, poor circulation of qi and blood, and internal generation of blood stasis, which blocks the meridians and affects the normal distribution and movement of body fluids, causing body fluids to accumulate, thereby generating phlegm-dampness, further blood stasis and phlegm-dampness blocking the meridians, and the obstruction of the meridians, so the disease occurs. In view of this cause of disease, the present invention uses ginseng, mistletoe, schisandra chinensis, and gastrodia elata as the main medicines to strengthen the body constitution, nourish the spleen and benefit the lungs, and strengthen the body and eliminate evil. Among them, ginseng can greatly replenish vital energy and has the effect of replenishing qi and strengthening deficiency. The classics record that gastrodia elata can "be taken for a long time to improve qi and strength, grow yin, be fat and healthy, lighten the body, and increase longevity". Schisandra chinensis nourishes the lungs and kidneys, while mistletoe nourishes the liver and kidneys and strengthens the tendons and bones. The auxiliary herbs cinnamon twig, saposhnikovia divaricata, and processed Evodia rutaecarpa nourish the liver and kidney yang, warm the meridians, dispel cold, and relieve pain. The adjuvant herbs Chuanxiong, Salvia miltiorrhiza, Angelica sinensis, Cortex moutan, Paeonia lactiflora, Scorpio, and Scolopendra subspinipes promote blood circulation, dissipate stasis, resolve toxins, and resolve stagnation, unblocking the meridians and relieving spasms. This unclogs the meridians and relieves pain. Tangerine peel, Pinellia ternata, and Herba scutellariae are also added to regulate qi and balance the middle qi, dissipate dampness, and resolve phlegm. Pinellia ternata is particularly important for treating phlegm-dampness. Roasted Licorice root tonifies qi and strengthens the spleen, harmonizing the other herbs. Together, these herbs strengthen the body's vital energy, dispel pathogenic factors, dispel cold and relieve spasms, unblock the meridians and relieve pain, and detoxify and resolve dampness.

[0029] The Chinese herbal preparations of the present invention are often taken as decoctions. They can also be prepared into any pharmaceutically acceptable preparation by adding conventional pharmaceutical excipients. For example, the raw materials described above can be ground into powders for oral administration, or manufactured into tablets or capsules for oral administration, or prepared into injectable preparations. The Chinese herbal preparations of the present invention can be prepared into any commonly used oral or injectable preparations using conventional methods using various conventional pharmaceutical excipients required for preparing different dosage forms, such as disintegrants, lubricants, and binders, and can also include optional coating materials.

[0030] The present invention will be further described below with reference to the embodiments.

[0031] Example 1 Weigh 10g of ginseng, 9g of herba mosilli, 4g of schisandra chinensis, 6g of gastrodia elata, 4g of processed evodia rutaecarpa, 7g each of cassia twig and siler, 20g of salvia miltiorrhiza, 9g each of angelica sinensis, ligusticum chuanxiong, and red peony root, 12g of moutan bark, 4g each of scorpio and centipede, 15g of leucopsis pilosula, 9g each of tangerine peel, pinellia tuber, and 9g each of prepared liquorice. Add water to the Chinese medicinal materials of the formula amount so that they are not covered by 2-3 cm of the Chinese medicinal materials, soak for 30 minutes, boil over high heat, then simmer for 20 minutes with slow fire, pour out the filtrate, add water and simmer for 20 minutes, and concentrate to 200ml after mixing the filtrates twice to obtain Chinese medicine decoction 1 of the present invention. Example 2

[0032] Respectively weigh 20g of Radix Ginseng, 15g of Herba Mori Parasitici, 6g of Fructus Schisandrae Chinensis, 9g of Rhizoma Gastrodiae, 3g of Fructus Evodiae (Processed), 6g each of Ramulus Cinnamomi, Radix Saposhnikoviae, 10g of Radix Salviae Miltiorrhizae, 6g each of Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Paeoniae Rubra, 8g of Cortex Moutan, 3g each of Scorpio, Scolopendra, 9g of Herba Deere, 6g each of Pericarpium Citri Reticulatae, Rhizoma Pinelliae, and 6g each of Radix Glycyrrhizae Preparata. The Chinese medicinal materials of the formula amount are added with water so as to cover 2-3 centimeters of the Chinese medicinal materials, soaked for 30 minutes, boiled over high heat, then decocted over low heat for 20 minutes, poured out the filtrate, then decocted in water for 20 minutes, and the filtrates were concentrated to 200ml after mixing twice to obtain Chinese medicine decoction 2 of the present invention. Example 3

[0033] Respectively weigh 15g of Radix Ginseng, 12g of Herba Mori Parasitici, 5g of Fructus Schisandrae Chinensis, 8g of Rhizoma Gastrodiae, 3g of Fructus Evodiae (Processed), 6g each of Cinnamon Twig and Radix Saposhnikoviae, 20g of Radix Salviae Miltiorrhizae, 9g each of Radix Angelicae Sinensis, Rhizoma Chuanxiong, and Radix Paeoniae Rubra, 12g of Cortex Moutan, 4g each of Scorpio and Scolopendra, 12g of Herba Deere, 8g each of Pericarpium Citri Reticulatae, Rhizoma Pinelliae Rhizoma, and Radix Glycyrrhizae Preparata. The Chinese medicinal materials of the formula amount are added with water so as to cover 2-3 centimeters of the Chinese medicinal materials, soaked for 30 minutes, boiled over high heat, then decocted over low heat for 20 minutes, the filtrate is poured out, and then decocted with water for 20 minutes. After the filtrates are mixed twice, they are concentrated to 200ml to obtain Chinese medicine decoction 3 of the present invention.

[0034] Example 4 Weigh respectively 10g of Radix Ginseng, 9g of Herba Mori Parasitici, 4g of Fructus Schisandrae Chinensis, 6g of Rhizoma Gastrodiae, 4.5g of Fructus Evodiae (Processed), 9g each of Ramulus Cinnamomi, Radix Saposhnikoviae, 20g of Radix Salviae Miltiorrhizae, 9g each of Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Paeoniae Rubra, 12g of Cortex Moutan, 4g each of Scorpio, Scolopendra, 9g of Herba Deere, 9g of Herba Citri Reticulatae, Rhizoma Pinelliae, and 6g each of Radix Glycyrrhizae Preparata. Add water to the Chinese medicinal materials of the formula quantity so that 2-3 centimeters of Chinese medicinal materials are not covered, soak for 30 minutes, boil over high heat, then decoct for 20 minutes with slow fire, pour out the filtrate, then add water and decoct for 20 minutes, and concentrate to 200ml after mixing the filtrates twice to obtain Chinese medicine decoction 4 of the present invention.

[0035] Example 5 Weigh respectively 15g of Radix Ginseng, 12g of Herba Mori Parasitici, 5g of Fructus Schisandrae Chinensis, 8g of Rhizoma Gastrodiae, 4g of Fructus Evodiae (Processed), 8g each of Ramulus Cinnamomi, Radix Saposhnikoviae, 15g of Radix Salviae Miltiorrhizae, 8g each of Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Paeoniae Rubra, 10g of Cortex Moutan, 3g each of Scorpio, Scolopendra, 12g of Herba Deere, 8g each of Pericarpium Citri Reticulatae, Rhizoma Pinelliae Rhizoma, and Radix Glycyrrhizae Preparata. Add water to the Chinese medicinal materials of the formula quantity so as not to exceed 2-3 centimeters of the Chinese medicinal materials, soak for 30 minutes, boil over high heat, then simmer for 20 minutes with slow fire, pour out the filtrate, add water and simmer for 20 minutes, and concentrate to 200ml after the filtrates are mixed twice to obtain Chinese medicine decoction 5 of the present invention.

[0036] Clinical study of the present invention in treating patients with varicella-zoster 1. Patients and Clinical Practice (1) Patient grouping: 80 patients with herpes zoster admitted to our hospital from January 2020 to January 2025 were randomly divided into a control group and an observation group, with 40 cases in each group. The two groups were compared in terms of age and onset time, and there was no statistically significant difference (P>0.05), indicating that they were comparable. See Table 1.

[0037] Table 1 Comparison of age and onset time before treatment between the two groups

[0038]

[0039] Note: Compared with the control group, △P>0.05.

[0040] (2) Inclusion criteria ① Meet the clinical diagnostic criteria for herpes zoster in the "Chinese Expert Consensus on Herpes Zoster"; ② First onset, with a course of disease less than or equal to 7 days; ③ Age 18-76 years; ④ Voluntarily participate in this study and sign the informed consent. Exclusion criteria: ① Patients with severe organ dysfunction such as heart, brain, liver, and kidney, or severe immune system diseases; ② Patients with other serious skin diseases; ③ Patients with a history of severe allergies to traditional Chinese medicine or Western medicine; (3) Treatment plan The control group received valacyclovir hydrochloride tablets (manufacturer: ** Group ** Pharmaceutical Factory; approval number: National Medicine Standard H10960079), 0.3g orally twice daily. The observation group received a traditional Chinese medicine preparation of the present invention, specifically: 15g of ginseng, 12g of parasitic loranthus, 5g of schisandra chinensis, 8g of gastrodia elata, 4g of processed evodia rutaecarpa, 8g each of cinnamon twig and saposhnikovia divaricata, 15g of salvia miltiorrhiza, 8g each of angelica sinensis, ligusticum chuanxiong, and red peony root, 10g of moutan bark, 3g each of scorpion and centipede, 8g each of tangerine peel and pinellia tuber, 12g of gypsophila scabra, and 8g of prepared liquorice root. One dose of decoction was taken daily, divided into two doses after meals. The efficacy was observed after 10 days, and the patients were followed up for 3 months.

[0041] (4) Observation indicators and efficacy judgment criteria: Comparison of clinical efficacy, clinical symptoms such as pain relief and complete scab formation time, VAS (visual analogue scale) scores of the two groups, and the incidence of PHN (postherpetic neuralgia) of the two groups.

[0042] ① Criteria for determining efficacy Cured: After treatment, the rash subsides, pain disappears, and scabs form completely, with no PHN. Markedly effective: After treatment, the number of rashes decreases significantly, pain is significantly alleviated, and most rashes scab over, but mild PHN symptoms may occur occasionally. Effective: After treatment, the number of rashes decreases, pain improves somewhat, and rashes partially scab over, although some patients may develop PHN. Ineffective: The rash does not decrease or may even increase, pain persists, the rash does not scab over, and new rashes may appear repeatedly. Some patients may develop PHN. The total effective rate = cure rate + marked effective rate + effective rate.

[0043] ②Evaluate indicators such as pain relief and complete scab formation time ③Comparison of pain levels between the two groups ④Comparison of the incidence of PHN between the two groups (5) Statistical methods Data were collated and statistically analyzed using R (version 4.5.0). Continuous data were first subjected to the Shapiro-Wilk normality test; if normal distribution was satisfied, the t-test was used; if not, the Wilcoxon rank-sum test was used. For incidence ratios, the Fisher test was used to determine the association between variables in a 2×2 contingency table. For enumeration data, the chi-square test was used based on theoretical frequency and sample size, and two-sided or one-sided tests were used based on the study objectives. P < 0.05 was considered statistically significant.

[0044] 2. Treatment Results (1) Comparison of clinical efficacy between the two groups of patients Comparison of clinical efficacy between the two groups showed that the total effective rate of the observation group was 97.50% (39 / 40), which was significantly higher than that of the control group (80.00% (32 / 40). The difference was statistically significant ( P <0.05). See Table 2 for details.

[0045] Table 2 Comparison of clinical treatment effects between the two groups of patients [cases (%)]

[0046] Note: Compared with the control group, △P<0.05. (2) Comparison of pain relief time and scab formation time between the two groups of patients after treatment The average time of pain relief and complete scab formation in the observation group was shorter than that in the control group, and the difference was statistically significant ( P<0.05), see Table 3 for details.

[0047] Table 3 Comparison of pain relief time and total scab formation time between the two groups

[0048]

[0049] Note: Compared with the control group, △P<0.05.

[0050] (3) Comparison of pain levels between the two groups There was no statistically significant difference in VAS scores between the two groups before treatment ( P >0.05), after treatment, the VAS scores of the two groups of patients decreased compared with those before treatment, and the VAS score of the observation group decreased significantly. After treatment, the VAS score of the observation group was significantly lower than that of the control group ( P <0.05), the difference was statistically significant. See Table 4 for details. Table 4 Comparison of VAS scores between the two groups (x±s, points)

[0051] Note: Compared with the control group after treatment, △ P <0.05; compared with the group before treatment, * P <0.05.

[0052] (4) Comparison of PHN incidence between the two groups After treatment, the incidence of PHN in the observation group was significantly lower than that in the control group ( P <0.05), the difference was statistically significant. See Table 5 for details. Table 5 Comparison of PHN incidence between the two groups

[0053] Note: Compared with the control group after treatment, △ P <0.05.

[0054] The above treatment data show that the Chinese medicine preparation of the present invention has an advanced formula and satisfactory efficacy, can quickly relieve the patient's pain and other symptoms, significantly shorten the patient's treatment course, and can significantly reduce the incidence of postherpetic neuralgia. Figures 1 to 6 These are 6 cases randomly selected from the observation group. After the patients took the medicament of the present invention for 7 days, their rashes were obviously scabbed.

Claims

1. A Chinese medicine preparation for treating varicella-zoster virus infection, characterized in that: The Chinese medicine preparation is calculated in parts by weight: 10-20 parts of ginseng, 9-15 parts of mistletoe, 4-6 parts of schisandra chinensis, 6-9 parts of gastrodia elata, 6-9 parts of cinnamon twig, 6-9 parts of siler, 3-4.5 parts of processed evodia rutaecarpa, 10-20 parts of salvia miltiorrhiza, 8-12 parts of moutan bark, 6-9 parts of red peony root, 1-5 parts of scorpion, 1-5 parts of centipede, 9-15 parts of leucanthemum, 6-9 parts of dried tangerine peel, 6-9 parts of pinellia, and 6-9 parts of roasted liquorice.

2. The Chinese medicine preparation for treating varicella-zoster virus infection according to claim 1, characterized in that: The traditional Chinese medicine preparation further comprises the following components in parts by weight: 6 to 9 parts of angelica sinensis and 6 to 9 parts of ligusticum chuanxiong.

3. The Chinese medicine preparation for treating varicella-zoster virus infection according to claim 2, characterized in that: The Chinese medicine preparation is calculated in parts by weight: 12-18 parts of ginseng, 10-14 parts of mistletoe, 4-6 parts of schisandra chinensis, 7-9 parts of gastrodia elata, 7-9 parts of cinnamon twig, 7-9 parts of siler, 3.5-4.5 parts of processed evodia rutaecarpa, 12-18 parts of salvia miltiorrhiza, 9-11 parts of moutan bark, 7-9 parts of red peony root, 7-9 parts of angelica, 7-9 parts of ligusticum, 7-9 parts of chuanxiong, 2-4 parts of scorpion, 2-4 parts of centipede, 10-14 parts of leucanthemum, 7-9 parts of dried tangerine peel, 7-9 parts of pinellia, and 7-9 parts of roasted liquorice.

4. The Chinese medicine preparation for treating varicella-zoster virus infection according to claim 2, characterized in that: The Chinese medicine preparation is calculated in parts by weight: 15 parts of Radix Ginseng, 12 parts of Herba Mori Parasitici, 5 parts of Fructus Schisandrae Chinensis, 8 parts of Rhizoma Gastrodiae, 8 parts of Twig of Cinnamomum Cinnamomum, 8 parts of Radix Saposhnikoviae, 4 parts of Processed Fructus Evodiae, 15 parts of Radix Salviae Miltiorrhizae, 10 parts of Cortex Moutan, 8 parts of Radix Paeoniae Rubra, 8 parts of Radix Angelicae Sinensis, 8 parts of Rhizoma Chuanxiong, 3 parts of Scorpio, 3 parts of Scolopendra, 12 parts of Herba Deerebi, 8 parts of Pericarpium Citri Reticulatae, 8 parts of Rhizoma Pinelliae, and 8 parts of Radix Glycyrrhizae Preparata.

5. A decoction of a traditional Chinese medicine preparation for treating varicella-zoster virus infection according to any one of claims 1 to 4, characterized in that: Add water to the formulated amount of Chinese medicinal materials to cover them by 2-3 cm, soak for 30 minutes, boil over high heat, then simmer over low heat for 20 minutes, pour out the filtrate, add water and simmer for another 20 minutes, mix the two filtrates and concentrate to 200 mL to obtain a decoction of the Chinese medicinal preparation.

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