A multimode liquid chromatography packing material modified with interpenetrating network hydrogel and aminated silica gel, its preparation method and application

By preparing interpenetrating network hydrogels on the surface of silica gel to modify amino silica gel, the problems of mechanical stability and non-specific adsorption of traditional hydrogels are solved, and efficient separation and analysis of compounds of different polarities is achieved by multi-mode liquid chromatography packing material.

CN120695803BActive Publication Date: 2026-07-03LANZHOU INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
LANZHOU INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES
Filing Date
2025-06-27
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

Existing multimode chromatography has not been widely applied in practical analysis processes. Traditional hydrogels have limitations in terms of mechanical stability and non-specific adsorption, making it difficult to achieve efficient separation of compounds with different polarities.

Method used

Aminated silica gel was modified with interpenetrating network hydrogel, and multi-mode liquid chromatography packing material was prepared on the silica gel surface by chemical polymerization technology. Combining hydrophilicity, hydrophobicity and ion exchange, the synergistic effect of multiple separation modes was achieved.

Benefits of technology

It achieves efficient separation and analysis of compounds with different polarities, such as nucleosides/bases, sulfonamides, polycyclic aromatic hydrocarbons, aniline compounds, and anions, with good separation selectivity and stability.

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Abstract

This invention discloses a multimode liquid chromatography packing material for aminated silica gel modified with an interpenetrating network hydrogel, its preparation method, and its applications, relating to the field of high-performance liquid chromatography (HPLC) separation and analysis technology. The packing material is obtained by modifying the surface of aminated silica gel with an interpenetrating network hydrogel formed from carboxymethyl chitosan and poly(N-isopropylacrylamide) using chemical polymerization. The packing material provided by this invention can be used for the separation and analysis of compounds of different polarities. The interpenetrating network structure formed by the two monomers gives the hydrogel-modified layer higher mechanical strength, and the different interaction sites enable multimode (hydrophilic chromatography mode, hydrophobic chromatography mode, and ion chromatography mode) separation and analysis of compounds with different polarities. The preparation method provided by this invention is simple, and the prepared packing material has significant application potential in the field of chromatographic separation and analysis.
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