Detection kit for tumor cells

Abstract

The invention discloses a tumor cell detection kit, and relates to the technical field of detection kits, the tumor cell detection kit comprises a detection uniformizing module, the detection uniformizing module comprises: a first gear rotatably arranged around a first axis of the first gear; the driving disc is in coaxial running fit with the first gear; the gear assembly further comprises at least one set of strip-shaped holes and arc-shaped holes which are matched with each other, the strip-shaped holes are formed in the radial direction of the first gear, the strip-shaped holes are in guide fit with movable assemblies, the movable assemblies comprise matching shafts matched with the arc-shaped side faces of the arc-shaped holes, and the strip-shaped holes and the arc-shaped holes are formed in the first gear and the driving disc respectively. According to the uniform detection module, through the matching mode of the driving disc and the first gear, the overall structural stability is high, the working requirement of low-speed centrifugation can be met, the working requirement of cell debris separation can be met, and the working efficiency is improved. The adaptability of the detection kit is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of detection kits, and in particular to a detection kit for tumor cells. Background Art

[0002] A tumor refers to a new growth formed by the proliferation of local tissue cells under the action of various tumorigenic factors. Because this new growth is mostly a space-occupying, block-like protrusion, it is also called a vegetation. Circulating tumor cells refer to tumor cells that spread and survive in the peripheral blood during the development of malignant tumors and are closely related to the metastasis and prognosis of the tumor.

[0003] Using a detection kit to detect tumor cells is a conventional detection method in this field. For example, Chinese invention patent application number 2024117324783 discloses a tumor cell detection kit and detection method thereof, which includes a reagent removal module, a reagent dripping module, and a detection uniformity module, thereby improving the ease and versatility of use of the detection kit and facilitating detection. The detection uniformity module can position the test tube and, by changing the test tube's posture, facilitate shaking the test tube when it is tilted and resuspending the sample when the test tube is in a vertical position. However, the above working method still has at least the following disadvantages: 1. When the state of the test tube is changed, it is based on the stepping motor set on the transmission gear to drive the screw rod to achieve the effect of adjusting the posture of the movable hinge seat. When the movable hinge seat is in a tilted state, the driving transmission gear rotates around the axis to shake the test tube fixed in the movable hinge seat. Since the amplitude of the test tube shaking is small and the shaking frequency is 6-20 times per minute, the shaking frequency is low. The above structure can meet the needs. However, in order to further improve the adaptability of the test kit, the requirements for the test kit are further improved, and it is required to have the function of separating cell fragments. However, when the test kit separates cell fragments, the cell fluid needs to be centrifuged at a speed of 800-900 rpm to remove fragments. Since the stepping motor and the driving screw rod are set on the transmission gear, the structural stability is not high. When the speed is too high, the vibration amount is large and cannot meet the low-speed centrifugation requirements. Summary of the Invention

[0004] The purpose of the present invention is to solve the above problems and provide a tumor cell detection kit.

[0005] To achieve the above-mentioned object, the technical solution of the present invention is: a tumor cell detection kit, comprising a uniform detection module, wherein the uniform detection module comprises: The first gear is rotatably arranged around its first axis; A driving plate, coaxially rotating with the first gear; It also includes at least one group of adaptive strip holes and arc holes, the strip holes are arranged along the radial direction of the first gear, the strip holes are guided and matched with a movable component, the movable component includes a matching shaft that matches the arc side surface of the arc hole, the strip holes and arc holes are respectively arranged on the first gear and the drive plate; the first gear and the drive plate are configured to rotate in the same direction with differential speed and at a constant speed around the first axis.

[0006] Furthermore, the strip-shaped holes and arc-shaped holes are provided with multiple groups evenly spaced around the first axis, one group is configured with a movable component, and the others are configured with a counterweight component, the counterweight component and the movable component have equal mass and move synchronously in the radial direction.

[0007] Furthermore, along the direction of the first axis, the movable component includes two positioning surfaces arranged at both ends of the strip hole.

[0008] Furthermore, the movable component includes a first sliding member and a second sliding member that are detachably connected, the second sliding member is provided with a first boss that slides with the strip hole guide, and the two positioning surfaces are end surfaces of the first sliding member and the second sliding member that are close to each other.

[0009] Furthermore, a positioning step is provided on the inner circumference of the strip-shaped hole, and two positioning surfaces are limitedly matched with both ends of the positioning step.

[0010] Furthermore, it also includes a plurality of stabilizing components, which are evenly spaced around the first axis. The stabilizing components include a bevel gear that is transmission-matched with the first driven gear and a driven gear that is circumferentially connected to the drive disc.

[0011] Furthermore, the driving disc is arranged above the first gear, and the lower surface of the first gear is provided with a bevel gear ring transmission-connected to the bevel gear, and the conical surface of the bevel gear ring expands outward from bottom to top.

[0012] Furthermore, the stabilizing assembly further includes a transmission assembly disposed between the driven gear and the bevel gear, and the transmission assembly includes a linkage state and a separation state.

[0013] Furthermore, the transmission assembly includes a second shaft that cooperates with the bevel gear transmission and a first shaft that is connected to the first driven gear transmission. The first shaft and the second shaft are coaxially arranged, and the first shaft and the second shaft are respectively equipped with a first friction disc and a second friction disc. A driving device is provided between the first friction disc and the second friction disc, and the driving device can drive the first friction disc to move toward each other.

[0014] Furthermore, the second friction disc is axially guided with the second shaft, the driving device includes a permanent magnet arranged on the second friction disc, and the first friction disc is equipped with an electromagnet.

[0015] Compared with the prior art, the tumor cell detection kit has the following beneficial effects: the detection uniformity module of the application is in a matching mode of the driving disc and the first gear, has high overall structural stability, can adapt to the working requirements of low-speed centrifugation, can meet the working requirements of cell fragment separation, and improves the adaptability of the detection kit. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 The detection uniformity module in the tumor cell detection kit Figure 1 .

[0017] Figure 2 The detection uniformity module in the tumor cell detection kit Figure 2 .

[0018] Figure 3 The top view structural schematic diagram of the detection uniformity module in the tumor cell detection kit.

[0019] Figure 4 The bottom view structural schematic diagram of the detection uniformity module in the tumor cell detection kit.

[0020] Figure 5 The exploded view structural schematic diagram of the detection uniformity module in the tumor cell detection kit.

[0021] Figure 6 The top view structural schematic diagram of the detection uniformity module hidden stable assembly in the tumor cell detection kit.

[0022] Figure 7 The bottom view structural schematic diagram of the first gear in the tumor cell detection kit.

[0023] Figure 8 The structural schematic diagram of the stable assembly in the tumor cell detection kit.

[0024] Figure 9 The sectional view structural schematic diagram of the stable assembly in the tumor cell detection kit.

[0025] Figure 10 The bottom view structural schematic diagram of the stable assembly in the tumor cell detection kit.

[0026] Figure 11 The structural schematic diagram of the movable assembly in the tumor cell detection kit.

[0027] Figure 12 The structural schematic diagram of the first gear and the movable assembly in the tumor cell detection kit.

[0028] Figure 13 It is the bottom structure diagram of the activity assembly in the tumor cell detection kit of the application.

[0029] Figure 14 It is the exploded structure diagram of the activity assembly in the tumor cell detection kit of the application Figure 1 .

[0030] Figure 15 It is the exploded structure diagram of the activity assembly in the tumor cell detection kit of the application Figure 2 .

[0031] Figure 16 It is the section structure diagram of the first gear and the driving gear disc connection in the tumor cell detection kit of the application.

[0032] In the figure: 1, the first gear; 10, the first tooth; 12, the strip-shaped hole; 120, the positioning step; 13, the bevel gear; 15, the connecting sleeve; 2, the driving disc; 20, the second tooth; 21, the arc-shaped hole; 22, the counterweight assembly; 25, the connecting shaft; 3, the activity assembly; 30, the first sliding piece; 301, the positioning groove; 302, the counterbore; 31, the second sliding piece; 310, the first boss; 311, the second boss; 312, the matching shaft; 3120, the threaded hole; 32, the connecting piece; 320, the sleeve body; 321, the arm plate; 33, the ear plate; 330, the rotating shaft; 34, the pin shaft; 35, the screw; 4, the stabilizing assembly; 40, the first driven gear; 401, the first shaft; 402, the first friction disc; 41, the first transmission wheel; 410, the second shaft; 411, the second friction disc; 412, the permanent magnet; 42, the second transmission wheel; 43, the bevel gear; 430, the gear shaft; 44, the shell; 45, the inner cylinder; 46, the end cover; 47, the electromagnet; 48, the intermediate wheel; 5, the support seat; 51, the detection device; 53, the thrust bearing; 54, the first bearing. DETAILED DESCRIPTION

[0033] The application will now be described in further detail with reference to the drawings. The drawings are simplified schematic illustrations of the basic structure of the application and therefore only show the components relevant to the application.

[0034] Example 1 Please refer to Figure 1-5 , the application provides a tumor cell detection kit, as a specific embodiment, which comprises a detection uniform module, the detection uniform module comprises: The first gear 1 is rotationally arranged around its first axis; The driving disc 2 is coaxially rotationally matched with the first gear 1; It also includes at least one group of adaptive strip holes 12 and arc holes 21, the strip holes 12 are arranged along the radial direction of the first gear 1, the strip holes 12 are guided and matched with a movable component 3, the movable component 3 includes a matching shaft 312 that matches the arc side surface of the arc hole 21, the strip holes 12 and the arc holes 21 are respectively provided on the first gear 1 and the drive disk 2; the first gear 1 and the drive disk 2 are configured to rotate in the same direction with differential speed and at a constant speed around the first axis.

[0035] Specifically, it should be noted that the structure of the tumor detection kit in the patent document "A tumor cell detection kit and its detection method" in this application is basically the same as that in the patent document described in the reference document. The improvement of the detection kit in this application over the background technology is that Figure 1-Figure 5 It includes a first gear 1, and a support base 5 is provided under the first gear 1. The first gear 1 rotates with the support base 5 and supports the first gear 1 through the support base 5. It should be noted that the first gear 1 is hydraulically connected to a drive motor, and the drive motor drives the first gear 1 to rotate around the axis. The drive motor is consistent with the setting method of the drive motor in the detection kit recorded in the background technology that is matched with the transmission gear. The specific structure of the drive motor is no longer shown in this application, nor is it described one by one.

[0036] refer to Figure 16 As a specific embodiment, the first gear 1 is coaxially provided with a connecting sleeve 15, and the outer sleeve of the connecting sleeve 15 is provided with a first bearing 401, which rotates with the support seat 5. The drive disc 2 is coaxially provided with a connecting shaft 25, and a thrust bearing 53 is provided between the outer circumference of the connecting shaft 25 and the connecting sleeve 15, so that the drive disc 2 and the first gear 1 are coaxially rotated. As a specific embodiment, refer to Figures 1-6 , an arc-shaped hole 21 is provided on the driving disk 2, and a strip-shaped hole 12 is provided on the first gear 1, wherein the strip-shaped hole 12 is provided along a radial direction away from the first axis 401, and the arc-shaped hole 21 and the strip-shaped hole 12 are provided correspondingly, and a movable component 3 is provided in the guide sliding fit in the strip-shaped hole 12, and the movable component 3 includes a matching shaft 312 that can pass through the arc-shaped hole 21, and the driving disk 2 and the first gear 1 are configured to be able to rotate in the same direction of circumferential differential speed and constant speed. Through the above-mentioned setting method, reference Figure 11 , an ear plate 33 can be set on the top of the matching shaft 312, and a pin 34 is passed through the ear plate 33, which is hinged with the connecting rod below the mounting plate through the pin 34. When working, refer to Figure 3 、 Figure 6In the initial state, the movable assembly 3 is at one end of the strip hole 12 close to the first axis. At this time, the matching shaft 312 abuts against the end of the arc hole 21. At this time, the axis of the movable ball seat is in a vertical state. At this time, the test tube fixed inside the movable ball seat is in a vertical state. When the test tube in the movable ball seat needs to be shaken, the first gear 1 is driven to rotate. At the same time, the drive disk 2 and the first gear 1 are controlled to rotate in the same direction at a differential speed, from the reference Figure 3 , rotate in the direction of rotation shown in the figure, at this time, the speed of the driving disk 2 is controlled to be less than the first gear 1, then the arc hole 21 and the strip hole 12 will rotate relative to each other, and the side of the arc hole 21 will drive the matching shaft 312, thereby driving the movable component 3 to move outward, thereby pulling the movable ball seat to tilt, so as to achieve the purpose of adjustment. After adjusting to the appropriate angle, the driving disk 2 and the first gear 1 are controlled to rotate at the same speed, thereby meeting the demand for shaking the test tube. When returning to the initial state, the driving disk 2 and the first gear 1 are controlled to rotate differentially, and the speed of the driving disk 2 is made greater than the speed of the first gear 1, thereby driving the matching shaft 312 back to the initial state. Through the cooperation between the driving disk 2 and the first gear 1, the overall structure has high stability, can adapt to the low-speed rotation demand of 500-800 rpm, can meet the working requirements of cell fragment separation, and improve the adaptability of the detection kit.

[0037] Furthermore, it should be noted that the control methods for the equal speed and differential speed co-directional rotation of the driving disc 2 and the first gear 1 are described below.

[0038] Specifically, as a preferred embodiment, the mating shaft 312 is a columnar member with a vertical axis, and the radial dimension and the difference R1 between the outer diameter R and the inner diameter r of the arc-shaped hole 21 are clearance-matched, and the fitting tolerance is 0.05mm-0.15mm. Through the above-mentioned setting method, the fitting accuracy of the mating shaft 312 and the arc-shaped hole 21 can be guaranteed, and the linearity and smoothness of the radial drive of the mating shaft 312 by the arc-shaped hole 21 can be guaranteed.

[0039] Further, as a preferred embodiment, refer to Figures 1-6 The strip holes 12 and arc holes 21 are provided with multiple groups evenly spaced around the first axis, one group is configured with a movable component 3, and the others are configured with a counterweight component 22. The counterweight component 22 has the same mass as the movable component 3 and moves synchronously in the radial direction.

[0040] Specifically, it can be understood that, since the movable component 3 is also in an eccentric state when the movable ball seat is driven to tilt, vibration will be generated due to the eccentricity during high-speed rotation. In order to reduce the vibration caused by the eccentricity of the movable component 3 and improve the stability of the entire structure, as a preferred embodiment, four groups of strip holes 12 and arc holes 21 are provided, one group of strip holes 12 and arc holes 21 is equipped with the movable component 3, and the other three groups are equipped with counterweight components 22. It should be noted that the specific structure of the counterweight component 22 is consistent with the movable component 3 and the weight is equal. When the drive disk 2 and the first gear 1 move differentially, the counterweight component 22 can move synchronously with the movable component 3 in the direction away from the axis or in the direction close to the axis, so that the counterweight component 22 can counterweight with the movable component 3, which can reduce vibration and improve stability when the first gear 1 and the drive disk 2 rotate.

[0041] Furthermore, it should be noted that the specific structure of the active component 3 is described below.

[0042] Further, specifically, as a specific embodiment, along the direction of the first axis, the movable component 3 includes two positioning surfaces provided at both ends of the strip hole 12. Specifically, refer to Figure 11-Figure 15 The strip hole 12 is set on the first gear 1, and the movable component 3 includes a first sliding member 30 and a second sliding member 31. The first sliding member 30 and the second sliding member 31 are detachably fixedly connected and are set on both sides of the first gear 1. The matching shaft 312 and the second sliding member 31 are integrally arranged. The two limiting surfaces, namely the surfaces where the first sliding member 30 and the second sliding member 31 are close to each other, are limited by the limiting surfaces at both ends of the strip hole 12, so that the axial movement of the movable component 3 can be reduced. When the movable ball seat is driven to deflect, the axial movement is small, which can improve the driving accuracy.

[0043] Furthermore, the sliding member includes a first sliding member 30 and a second sliding member 31 that are detachably connected. The second sliding member 31 is provided with a first boss 310 that is in sliding engagement with the strip-shaped hole 12. The first positioning surface is the end surface of the first sliding member 30 and the second sliding member 31 that are close to each other. Specifically, by providing the first boss 310, when the first sliding member 30 and the second sliding member 31 are connected, the height of the first boss 310 is used to determine the spacing between the first sliding member 30 and the second sliding member 31, so that the spacing is adapted to the axial dimension of the strip-shaped hole 12, thereby ensuring that the distance between the two limiting surfaces is adapted to the axial dimension of the strip-shaped hole 12.

[0044] Furthermore, as a preferred embodiment, a positioning step 120 is provided on the inner circumferential surface of the strip-shaped hole 12 , and two positioning surfaces are limitedly matched with both ends of the positioning step 120 .

[0045] Specifically, refer to Figure 12-15, bar-shaped blind holes are provided on both plate surfaces of the first gear 1 corresponding to the bar-shaped holes 12, thereby forming a positioning step 120, the first sliding member 30 is a plate-shaped member, and the second sliding member 31 is also a plate-shaped member, and the thickness of the first sliding member 30 and the second sliding member 31 is not greater than the depth of the bar-shaped blind hole, the first boss 310 is cylindrical, and the size is clearance-matched with the width of the bar hole 12, and a second boss 311 is provided at the end of the first boss 310, and a positioning groove 301 corresponding to the second boss 311 is provided on the plate surface of the first sliding member 30, and a countersunk hole 302 is provided at the bottom of the positioning groove 301, which can be threadedly connected to the threaded hole 3120 at the end of the second step through a locking member.

[0046] Further, refer to Figure 1 、 Figure 15 The structure of the inertia member is roughly the same as that of the movable component 3, and also includes a first sliding member 30, a second sliding member 31 and a matching shaft 312. The end of the matching shaft 312 of the movable component 3 is provided with a threaded hole 3120, and the upper end of the matching shaft 312 is detachably fixedly connected to a connecting member 32. The connecting member 32 includes a sleeve body 320 that is fitted with the upper end of the matching shaft 312, a screw 35 that passes through the sleeve body 320 and is threadedly connected to the threaded hole 3120, an arm plate 321 connected to the sleeve body 320, and a rotating shaft 330 rotatably set at the end of the arm plate 321, an ear plate 33 is provided at the upper end of the rotating shaft 330, and the ear plate 33 is connected to the movable ball seat. When in use, the connecting member 32, the rotating shaft 330, and the ear plate 33 are all made of lightweight materials such as aluminum alloy or engineering plastics.

[0047] It should be noted that, in this embodiment, the movable ball seat, the connecting rod and the mounting plate are all consistent with the corresponding components in the detection kit in the background art.

[0048] Example 2 Furthermore, the present application provides a tumor cell detection kit, which, as a further improvement, aims to further improve the stability of the detection uniformity module during low-speed centrifugation, improve the adaptability of the uniformity module, and improve the function of the detection kit. The present application also includes multiple stabilizing components 4, reference Figure 7-10 , multiple stabilizing components 4 are evenly spaced around the first axis, and the stabilizing components 4 include a bevel gear 43 that is in transmission cooperation with the first driven gear 40 and a driven gear that is circumferentially connected to the drive disk 2. By setting up multiple stabilizing components 4, the stabilizing components 4 can provide support and stability by axially driving contact with the first driven gear 40 and the drive disk 2.

[0049] Specifically, refer to Figures 1-6The stabilizing assembly 4 includes 3 groups. The outer peripheral surface of the driving disk 2 is provided with a second tooth 20. The first gear 1 includes a first tooth 10. The stabilizing assembly 4 includes a shell 44. The shell 44 is used to connect to the bottom of the detection reagent kit to provide support and installation space. The first driven gear 40 is driven and connected to the first shaft 401. The bevel gear 43 is driven and connected to the gear shaft 430. The gear shaft 430 and the first shaft 401 are arranged in parallel and spaced apart. The first driven gear 40 is driven and connected to the second tooth 20 of the driving disk 2, and the bevel gear 43 is driven and connected to the first gear 1. During operation, when the first gear 1 and the driving disk 2 rotate, the first driven gear 40 and the bevel gear 43 are driven to rotate. The vibration of the first gear 1 and the driven disk can be reduced by the transmission torque between the gears, and the radial support can be provided by the first driven gear 40 and the bevel gear 43 to improve the stability of the entire structure.

[0050] Further, as a preferred embodiment, refer to Figure 7 The driving disk 2 is arranged above the first gear 1. The lower surface of the first gear 1 is provided with a bevel gear ring 13 that is transmission-connected to the bevel gear 43. The conical surface of the bevel gear ring 13 expands outward from bottom to top.

[0051] Specifically, the lower surface of the first gear 1 is provided with a bevel gear ring 13, and the bevel gear ring 13 is provided integrally with the first gear 1. Figure 1 The housing 44 is disposed below the first bevel gear, and the bevel gear 43 can provide upward and radially inward support forces while meshing with the bevel gear ring 13, thereby improving the stability effect.

[0052] Further, as a specific implementation method, refer to Figure 4 、 Figure 9 The stabilizing assembly 4 further includes a transmission assembly disposed between the driven gear and the bevel gear 43, and the transmission assembly includes a linkage state and a separation state.

[0053] Specifically, it should be noted that, as a preferred embodiment, the driving stabilization component 4 includes three groups, and transmission components are arranged between the bevel gears 43 and the driven gears of the three groups of stabilization components 4, and the transmission ratios of the transmission components of the three groups of stabilization components 4 are different. The transmission component of the first group of transmission components is synchronously set, the transmission component of the second group of stabilization components 4 is deceleration set, and the transmission component of the third group of stabilization components is speed-increasing set; that is, when the transmission component of the first group of stabilization components 4 is in a linkage state, the first gear 1 is driven to rotate, and the bevel gear 43 is driven to rotate through the bevel gear ring 13, and the bevel gear 43 drives the first driven gear 40 to rotate through the transmission component, and then drives the drive disk 2 to rotate through the first driven gear 40. At this time, the speed at which the drive disk 2 is driven to rotate is equal to the speed of the first gear 1, which is a synchronous setting.

[0054] The transmission assembly of the second group of stabilizing components 4 is a deceleration setting, that is, the first gear 1 is driven to rotate, and the bevel gear 43 is driven to rotate through the bevel gear ring 13. The bevel gear 43 drives the first driven gear 40 to rotate through the transmission assembly, and then drives the driving plate 2 to rotate through the first driven gear 40. At this time, the driving plate 2 is driven to rotate at a speed lower than the speed of the first gear 1. At this time, there is a speed difference between the first gear 1 and the driving plate 2. Figure 3 , then the arc-shaped hole 21 can drive the movable component 3 to move radially outward, which is a deceleration setting.

[0055] The transmission assembly of the third group of stabilizing components 4 is a speed-increasing setting, that is, the first gear 1 is driven to rotate, and the bevel gear 43 is driven to rotate through the bevel gear ring 13. The bevel gear 43 drives the first driven gear 40 to rotate through the transmission assembly, and then drives the driving plate 2 to rotate through the first driven gear 40. At this time, the driving plate 2 is driven to rotate at a speed greater than the speed of the first gear 1. At this time, there is a speed difference between the first gear 1 and the driving plate 2. Figure 3 , then the arc-shaped hole 21 can drive the movable component 3 to move radially toward the axis, which is a speed-increasing setting.

[0056] It should be noted that when the transmission assembly is in the disengaged state, the bevel gear 43 and the first driven gear 40 are separated and no transmission occurs.

[0057] The present application controls the coordinated operation of the transmission components in the three groups of stabilizing components 4, thereby achieving synchronous rotation and differential rotation in the same direction of the driving disk 2 and the first gear 1, and driving the movable component 3. While providing stable support for the first gear 1 and the driving disk 2, it can also take into account the driving of the movable component 3. The overall structure is simple and reasonable, the layout is compact, and it can adapt to the use in small spaces.

[0058] Furthermore, through the above-mentioned setting method, in actual use, when the uniform module shakes the test tube, the transmission components of the second stabilizing component 4 and the third stabilizing component 4 can be alternately switched in state, and the movable component 3 can be driven back and forth, so that the test tube can rotate circumferentially and move radially at the same time, which can better simulate the manual shaking situation and achieve a better effect of uniform cell fluid.

[0059] Furthermore, the method for using the tumor cell detection kit provided in this application comprises the following steps: Step 1: In the initial state, the movable component 3 is in the initial position close to the first axis, and the transmission components of the second group of stabilizing components 4 are controlled to switch to the linkage state, and the transmission components of the first and third groups of stabilizing components 4 are both in the separated state; Step two, drive the first gear 1 rotation, through the second group of stable components 4 to drive the drive plate 2, make the drive plate 2 and the first gear 1 same direction rotation, the rotation speed is less than the first gear 1, then the arc hole 21 drive the counterweight assembly 22 and the movable assembly 3 along the radial outward movement, pull the movable ball seat tilt, until the movable ball seat tilt to the appropriate angle, control the second group of stable components 4 transmission assembly switch to the separation state; Step three, control the first group of stable components 4 transmission assembly switch to the linkage state, the second group and the third group of transmission assembly is in the separation state, at this time drive the first gear 1 and the drive plate 2 synchronous rotation, then can carry on to the movable ball seat inside test tube shake operation or low speed separation operation; Step four, after completing the shake operation or low speed separation operation, control the third stable components 4 transmission assembly switch to the linkage state, the other two groups of drive assembly switch to the separation state, continue to drive the first gear 1 rotation, then the drive plate 2 rotation speed is greater than the first gear 1 drive rotation speed, drive the movable assembly 3 and the counterweight assembly 22 back to the initial state, the movable ball seat to the vertical state.

[0060] Further, between step three and step four, also includes: S31, in the shake operation, the first group of stable components 4 and the third group of stable components 4 transmission assembly switch to the linkage state alternately, and only one group of transmission assembly in the three groups of stable components 4 remains in the linkage state, through the above setting mode, can better simulate the effect of manual shaking.

[0061] Further, as a specific embodiment, reference Figure 2 , Figure 4 , Figure 10 , the transmission assembly includes the second shaft 410 and the first shaft 401 which are in transmission cooperation with the bevel gear 43 and transmission connection with the first driven gear 40, the first shaft 401 and the second shaft 410 are coaxially arranged, the first shaft 401 and the second shaft 410 are respectively configured with the first friction disc 402 and the second friction disc 411, the driving device is arranged between the first friction disc 402 and the second friction disc 411, the driving device can drive the first friction disc 402 opposite movement.

[0062] Specifically, the first driven gear 40 is transmission-connected to the first shaft 401, the bevel gear 43 is transmission-connected to the gear shaft 430, the lower end of the gear shaft 430 is provided with a second transmission wheel 42, and below the first shaft 401, a second shaft 410 is coaxially arranged at intervals, and the lower end of the second shaft 410 is provided with a first transmission wheel 41, and an intermediate wheel 48 is provided between the first transmission wheel 41 and the first transmission wheel 41. The intermediate wheel 48 can rotate with the bottom surface of the detection reagent kit below, and the second shaft 410 and the first shaft 401 are respectively provided with a first friction plate and a second friction plate. By setting a driving device, the first friction plate and the second friction plate can be driven to contact and separate. When in contact, the transmission component is in a linkage state, and when separated, the transmission component is in a separation state.

[0063] It should be noted that the three sets of transmission components can adjust the transmission ratio of the first transmission wheel 41 and the second transmission wheel 42, thereby realizing three driving modes.

[0064] Further, as a specific embodiment, refer to Figure 9 The second friction disc 411 is axially guided with the second shaft 410. The driving device includes a permanent magnet 412 disposed on the second friction disc 411, and the first friction disc 402 is equipped with an electromagnet 47. Specifically, an inner cylinder 45 coaxial with the first shaft 401 is disposed within the housing 44. The lower end of the inner cylinder 45 is threadedly connected to the end cover 46. The second rotating member is disposed on the end cover 46. The second friction disc 411 is slidably sleeved with the second shaft 410 via a spline sleeve. The first friction plate is fixedly disposed at the lower end of the first shaft 401. A permanent magnet 412 is disposed on the lower surface of the second friction plate. The end cover 46 is equipped with an electromagnet 47. When energized, the electromagnet 47 can provide a magnetic force that repels the permanent magnet 412, driving the second friction plate upward to contact the first friction plate. When demagnetized, the second friction plate falls under the action of gravity and switches to a separated state.

[0065] Further, as a specific embodiment, refer to Figure 16 The lower end of the connecting sleeve 15 is detachably fixed with a support member, and a detection sensor device is provided on the support member. The detection sensor yellow paper is used to detect the deflection angle between the connecting sleeve 15 and the connecting shaft 25. The detection device 51 can use an angle sensor in the prior art. When the first gear 1 and the driving disk 2 are in the initial state, the matching shaft 312 of the movable component 3 is at the end of the arc hole 21. At this time, the detection value of the angle sensor is the initial value. During operation, the relative deflection angle of the first gear 1 and the driving disk 2 can be obtained by obtaining the detection value of the angle sensor, thereby obtaining the position of the matching shaft 312. The first stable component, the second stable component and the third stable component are controlled according to the detection value of the angle sensor to meet working requirements.

[0066] Obviously, the above embodiments are merely examples for clarity of explanation and are not intended to limit the implementation methods. Those skilled in the art will readily appreciate that other variations or modifications based on the above descriptions are possible. It is not necessary and impossible to enumerate all implementation methods here. Obvious variations or modifications arising therefrom remain within the scope of protection of the present invention.

Claims

1. A tumor cell detection kit, comprising a uniform detection module, characterized in that: The detection uniformity module includes: A first gear (1) is arranged to rotate around its first axis; A driving disc (2) is coaxially rotated with the first gear (1); The invention also includes at least one group of adapted strip holes (12) and arc holes (21), wherein the strip holes (12) are arranged along the radial direction of the first gear (1), and the strip holes (12) are guided by a movable component (3), wherein the movable component (3) includes a matching shaft (312) that matches the arc side surface of the arc hole (21), and the strip holes (12) and the arc holes (21) are respectively provided on the first gear (1) and the driving disk (2); the first gear (1) and the driving disk (2) are configured to rotate in the same direction with differential speed and at a constant speed around the first axis.

2. A tumor cell detection kit according to claim 1, characterized in that: The strip-shaped holes (12) and the arc-shaped holes (21) are provided with a plurality of groups evenly spaced around the first axis, one group being provided with a movable component (3), and the other being provided with a counterweight component (22), wherein the counterweight component (22) and the movable component (3) have equal mass and move synchronously in the radial direction.

3. A tumor cell detection kit according to claim 1, characterized in that: Along the direction of the first axis, the movable component (3) comprises two positioning surfaces arranged at both ends of the strip-shaped hole (12).

4. A tumor cell detection kit according to claim 3, characterized in that: The movable assembly (3) comprises a first sliding member (30) and a second sliding member (31) which are detachably connected. The second sliding member (31) is provided with a first boss (310) which is in sliding engagement with the strip hole (12). The two positioning surfaces are end surfaces of the first sliding member (30) and the second sliding member (31) which are close to each other.

5. A tumor cell detection kit according to claim 4, characterized in that: The inner circumferential surface of the strip-shaped hole (12) is provided with a positioning step (120), and the two positioning surfaces are limitedly matched with the two ends of the positioning step (120).

6. The tumor cell detection kit according to claim 1, characterized in that: It also includes a plurality of stabilizing assemblies (4), the plurality of stabilizing assemblies (4) being evenly spaced around the first axis, the stabilizing assemblies (4) including a bevel gear (43) in transmission engagement with the first driven gear (40) and a driven gear circumferentially connected to the drive disc (2).

7. A tumor cell detection kit according to claim 6, characterized in that: The driving disc (2) is arranged above the first gear (1), and a bevel gear ring (13) is provided on the lower surface of the first gear (1) and is transmission-connected to the bevel gear (43). The conical surface of the bevel gear ring (13) expands outward from bottom to top.

8. A tumor cell detection kit according to claim 7, characterized in that: The stabilizing assembly (4) further comprises a transmission assembly arranged between the driven gear and the bevel gear (43), wherein the transmission assembly comprises a linkage state and a separation state.

9. A tumor cell detection kit according to claim 8, characterized in that: The transmission assembly comprises a second shaft (410) that is in transmission engagement with the bevel gear (43) and a first shaft (401) that is in transmission connection with the first driven gear (40). The first shaft (401) and the second shaft (410) are coaxially arranged. The first shaft (401) and the second shaft (410) are respectively provided with a first friction disc (402) and a second friction disc (411). A driving device is provided between the first friction disc (402) and the second friction disc (411). The driving device is capable of driving the first friction disc (402) to move toward each other.

10. The tumor cell detection kit according to claim 9, characterized in that: The second friction disc (411) is axially guided with the second shaft (410), the driving device comprises a permanent magnet (412) arranged on the second friction disc (411), and the first friction disc (402) is provided with an electromagnet (47).

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