A method for continuously preparing folic acid by tube reactor opposing flow

Abstract

The application relates to the technical field of organic synthesis, and discloses a method for continuously preparing folic acid through pipe reactor collision. High pressure of a pipe reactor is used to make sodium pyrosulfite and N-(4-aminobenzoyl)-L-glutamic acid and 2,4,5-triamino-6-hydroxypyrimidine sulfate homogeneously disperse, raw materials are fully dispersed under the condition of less aqueous solvent, high-speed flow generated by high pressure is used to make N-(4-aminobenzoyl)-L-glutamic acid, 2,4,5-triamino-6-hydroxypyrimidine sulfate and trichloroacetone collide to occur a cyclization reaction, and the problem that material reaction is insufficient due to folic acid deposition and wrapping is avoided; sodium carbonate solution is sprayed to the continuous collision liquid flow, loss of raw materials caused by local alkali hydrolysis of trichloroacetone is avoided, the purity and yield of folic acid crude product are significantly improved, and the amount of waste water is reduced. The whole preparation process is a closed pipeline and a closed container, odor volatilization is avoided to affect the operation space, automatic control is easy, and the method is suitable for industrial production.

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