Nerve-calming and sleep-aiding composition containing theanine as well as preparation method and application of nerve-calming and sleep-aiding composition

Abstract

The invention belongs to the technical field, and particularly discloses a tranquilizing and sleep-aiding composition containing theanine as well as a preparation method and application of the tranquilizing and sleep-aiding composition. The nerve soothing and sleep aiding composition comprises the following raw material components in parts by weight: 8-10 parts of theanine, 2-5 parts of a lucid ganoderma extract, 2-4 parts of a lophatherum gracile extract, 1-3 parts of a piper laetispicum extract and 1-2 parts of sophora flowers. All the raw materials of the composition have a synergistic effect, the sleep quality can be effectively improved, all the raw materials are from medicinal and edible materials, and compared with common sedative drugs, the composition is good in safety, free of dependency and tolerance and free of adverse reaction.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of nutritional products, in particular to a composition containing theanine for soothing the nerves and helping sleep, and a preparation method and application thereof. BACKGROUND

[0002] Sleep disorders refer to various functional disorders in the sleep-wake process, including insomnia, excessive sleepiness, sleep breathing disorders and sleep behavior abnormalities caused by various reasons. The main clinical manifestations are abnormal sleep quantity (excessive increase or deficiency) and abnormal episodes in sleep (sleepwalking, sleep talking, nightmares, night terrors, tooth grinding, involuntary jumping of muscles or limbs). Sleep disorders are usually caused by long-term mental conflicts or excessive mental burden, improper long-term handling of mental and physical labor, and post-illness weakness.

[0003] Insomnia can cause fatigue, restlessness, general discomfort, lack of energy, slow reaction, headache, inability to concentrate, and in severe cases, can lead to schizophrenia and depression, anxiety, autonomic nervous dysfunction and other functional diseases, as well as various systemic diseases (such as cardiovascular system, digestive system, etc.).

[0004] Currently, Western medicine mainly uses drug therapy, which can be divided into six categories: ① benzodiazepines ② antidepressants ③ antihistamines ④ barbiturates and non-barbiturates ⑤ antipsychotic drugs and other sedatives ⑥ melatonin. Among them, benzodiazepine drugs are the main ones, and their main pharmacological effects are anti-anxiety, sedation, hypnotic, anticonvulsant and skeletal muscle relaxation. The main action pathway is to promote the release of inhibitory neurotransmitters such as gamma-aminobutyric acid (GABA) and glycine in the brain, and inhibit the production and release of 5-HT, thereby producing anxiolytic effects. However, long-term and large-scale use of commonly used benzodiazepines and non-benzodiazepine sedative hypnotics can produce serious adverse reactions, making patients prone to tolerance and dependence.

[0005] Therefore, it is necessary to develop a natural, safe and mild food that can effectively improve sleep and prevent or treat sleep disorders to alleviate and solve the suffering of patients. SUMMARY

[0006] In view of the above, it is necessary to provide a composition containing theanine for soothing the nerves and helping sleep, and a preparation method and application thereof. The various raw materials of the composition of the present application synergistically act to effectively improve sleep quality, and all raw materials are derived from medicinal and edible materials. Compared with common sedative drugs, it has good safety, no dependence and tolerance, and no adverse reactions.

[0007] To achieve the above purpose, the technical scheme adopted by the present application is:

[0008] The theanine-containing composition for soothing nerves and helping sleep comprises the following raw material components in parts by weight: theanine 8-10 parts, Ganoderma lucidum extract 2-5 parts, Ginkgo biloba extract 2-4 parts, Piper methysticum extract 1-3 parts and Sophora japonica 1-2 parts.

[0009] Further, the theanine-containing composition for soothing nerves and helping sleep comprises the following raw material components in parts by weight: theanine 9 parts, Ganoderma lucidum extract 4 parts, Ginkgo biloba extract 3 parts, Piper methysticum extract 2 parts and Sophora japonica 1.8 parts.

[0010] The application further provides a preparation method of the theanine-containing composition for soothing nerves and helping sleep, which comprises the following steps: crushing Sophora japonica, mixing the crushed Sophora japonica with theanine, Ganoderma lucidum extract, Ginkgo biloba extract and Piper methysticum extract, and sieving again to obtain the composition for soothing nerves and helping sleep.

[0011] The application further provides a use of the composition in the preparation of a nutritional product for improving sleep quality.

[0012] Further, the nutritional product is in the form of powder, granules, tablets or solution.

[0013] Further, the nutritional product further comprises auxiliary materials.

[0014] The application has the following beneficial effects:

[0015] Theanine and Ganoderma lucidum in the application can better inhibit nerve excitation, enhance the regulation of the neurotransmitter system and protect nerve cells, thereby improving sleep quality and sleep persistence; the combination of Ginkgo biloba, Piper methysticum and Sophora japonica can effectively enhance the regulation of the expression of monoamine neurotransmitters or receptors, thereby having better calming and hypnotic effects and further shortening sleep latency. More importantly, the combination of the above five components has multiple action targets and multiple effects, and can comprehensively improve sleep health. DETAILED DESCRIPTION

[0016] To make the technical problems, technical solutions and advantages of the application clearer, specific embodiments will be described in detail below.

[0017] All features disclosed in this specification, or all steps of any methods or processes disclosed, can be combined in any manner, except where features or steps are mutually exclusive.

[0018] Any feature disclosed in this specification, unless stated otherwise, is one example only of the many equivalent or similar features.

[0019] First, the embodiment provides a theanine-containing composition for soothing nerves and helping sleep.

[0020] Specifically, the theanine-containing composition for soothing nerves and sleeping in the embodiment includes the following raw material components in parts by weight: theanine 8-10 parts, Ganoderma lucidum extract 2-5 parts, Ginkgo biloba extract 2-4 parts, Piper methysticum extract 1-3 parts, and Sophora japonica 1-2 parts.

[0021] The theanine-containing composition for soothing nerves and sleeping in the embodiment is obtained by further compounding Ganoderma lucidum extract, Ginkgo biloba extract, Piper methysticum extract, and Sophora japonica on the basis of theanine. The different components of the theanine-containing composition for soothing nerves and sleeping in the embodiment have multiple action targets, and the effect of soothing nerves and sleeping is improved mainly by improving sleep quality and shortening sleep time.

[0022] For example, in the embodiment, the content of each component is as follows in parts by weight:

[0023] The content of theanine includes but is not limited to: 8 parts, 8.3 parts, 8.5 parts, 8.8 parts, 9 parts, 9.5 parts, 9.7 parts, and 10 parts.

[0024] The content of Ganoderma lucidum extract includes but is not limited to: 2 parts, 2.2 parts, 2.5 parts, 2.7 parts, 3.0 parts, 3.3 parts, 3.5 parts, 3.8 parts, 4.0 parts, 4.1 parts, 4.5 parts, 4.9 parts, and 5.0 parts.

[0025] The content of Ginkgo biloba extract includes but is not limited to: 2 parts, 2.4 parts, 2.5 parts, 2.8 parts, 3.0 parts, 3.2 parts, 3.5 parts, 3.7 parts, and 4.0 parts.

[0026] The content of Piper methysticum extract includes but is not limited to: 1 part, 1.2 parts, 1.5 parts, 1.9 parts, 2.0 parts, 2.2 parts, 2.5 parts, 2.8 parts, and 3.0 parts.

[0027] The content of Sophora japonica extract includes but is not limited to: 1 part, 1.2 parts, 1.5 parts, 1.7 parts, 1.8 parts, and 2.0 parts.

[0028] Preferably, in the embodiment, the theanine-containing composition for soothing nerves and sleeping includes the following raw material components in parts by weight: theanine 9 parts, Ganoderma lucidum extract 4 parts, Ginkgo biloba extract 3 parts, Piper methysticum extract 2 parts, and Sophora japonica 1.8 parts.

[0029] For example, in the embodiment, the content of each component is as follows in parts by weight:

[0030] The preparation method of the Ganoderma lucidum extract is as follows: after slicing and cleaning Ganoderma lucidum and drying, the Ganoderma lucidum is extracted twice under the conditions of a liquid-to-material ratio of 28:1 (mL / g), ultrasonic time of 55 min, and ultrasonic power of 800 W, and the extract is combined; after the extract is concentrated, purified, and freeze-dried, the Ganoderma lucidum extract is obtained.

[0031] The preparation method of the extract of Gastrodia elata Blume is as follows: Gastrodia elata Blume is crushed and sieved to obtain Gastrodia elata Blume powder; the Gastrodia elata Blume powder is extracted once under the conditions of a liquid-to-material ratio of 10:1 (mL / g), an ultrasonic time of 35 min, and an ultrasonic power of 600 W, and then the obtained extract is concentrated, purified, and freeze-dried to obtain the extract of Gastrodia elata Blume.

[0032] The preparation method of the extract of Gymnophyton chevalieri is as follows: the aboveground part of Gymnophyton chevalieri is coarsely crushed, put into an extraction tank, 15 times the weight of 80% ethanol is added, and reflux extraction is performed for 2 hours; filtration is performed, and the two times of filtrates are combined; the filtrate is concentrated into a decoction at 65°C under reduced pressure; the decoction is dissolved with ethanol and then added into a chromatographic column with macroporous adsorption resin for elution; the eluate is collected and concentrated to dryness to obtain the extract of Gymnophyton chevalieri.

[0033] The composition for soothing the nerves and helping sleep of the present embodiment can be prepared by using a conventional method known in the art.

[0034] Exemplarily, the preparation method comprises the following steps:

[0035] The components are weighed according to the proportion;

[0036] The components are mixed uniformly to obtain the composition for soothing the nerves and helping sleep.

[0037] The preparation method will be further described below.

[0038] The Flos Sophorae is crushed and sieved through an 80-mesh sieve, mixed uniformly with theanine, Ganoderma lucidum extract, extract of Gastrodia elata Blume, and extract of Gymnophyton chevalieri, sieved again through an 80-mesh sieve, and then dried in an oven at 45°C for 15 min to obtain the composition for soothing the nerves and helping sleep.

[0039] The use method of the composition for soothing the nerves and helping sleep will be described in detail below.

[0040] The composition for soothing the nerves and helping sleep of the present embodiment can be used by being added into drinking water for brewing / soaking and then being drunk.

[0041] Exemplarily, the solid-liquid ratio of the composition for soothing the nerves and helping sleep and drinking water is 1:70-90 g / mL, and specifically can be 1:70 g / mL, 1:75 g / mL, 1:80 g / mL, 1:85 g / mL, or 1:90 g / mL.

[0042] Generally, the temperature of the added drinking water is 85-100°C, and preferably 90°C; the brewing / soaking time is generally 3-5 min, and preferably 5 min.

[0043] For the convenience of use, the composition for soothing the nerves and helping sleep can also be made into a tea bag form with a corn fiber bag, for example, with a weight of 5-10 g / bag.

[0044] Next, the use of the above-mentioned composition for soothing the nerves and assisting sleep will be further described.

[0045] In view of the composition for soothing the nerves and assisting sleep of the present embodiment can improve insomnia and improve sleep quality. Therefore, the composition for soothing the nerves and assisting sleep provided in the present embodiment can be used for the preparation of a nutritional product for preventing, alleviating or treating insomnia symptoms.

[0046] That is, the composition for soothing the nerves and assisting sleep of the present embodiment can be used as the basis for adding food / medically acceptable adjuvants to prepare a medicine for preventing, alleviating or treating insomnia symptoms.

[0047] Illustratively, the insomnia symptoms include, but are not limited to, difficulty falling asleep, decreased sleep quality, short sleep time, etc.

[0048] Illustratively, the dosage form of the nutritional product is powder, granules, tablets or solution.

[0049] It should be understood that the adjuvants acceptable for the nutritional product used in the present embodiment refer to non-toxic carriers, adjuvants or vehicles that do not destroy the pharmacological activity of the composition for soothing the nerves and assisting sleep prepared together.

[0050] The adjuvants, adjuvants or vehicles acceptable for the nutritional product that can be used in the composition of the present embodiment include, but are not limited to, wetting agents, binders, disintegrants, taste modifiers. The types and amounts of the above-mentioned wetting agents, binders, disintegrants or taste modifiers should comply with the relevant provisions of the Chinese Pharmacopoeia.

[0051] For example, the disintegrant is selected from one or more of sodium carboxymethyl cellulose CMC, CMC-Na, HPM.

[0052] It should be understood that the above-mentioned adjuvants can be selected in combination with the specific dosage form of the nutritional product.

[0053] The nutritional product provided in the present embodiment can be administered by many ways, including but not limited to oral, inhalation, parenteral inhalation or other ways. For example, the nutritional product used herein is administered orally.

[0054] The present application will be further described below in conjunction with the examples. It should be understood that these examples are only used to illustrate the present application and not to limit the scope of the present application.

[0055] Examples 1-3

[0056] Examples 1-3 respectively provide the composition for soothing the nerves and assisting sleep as shown in Table 1, wherein each component in the composition for soothing the nerves and assisting sleep is by weight fraction.

[0057] Table 1: Composition of the composition for soothing the nerves and assisting sleep of Examples 1-3 (weight fraction)

[0058] Components Example 1 Example 2 Example 3 Theanine 8 9 10 Ganoderma extract 2 4 5 Gastrodia extract 2 3 4 Piper methysticum extract 1 2 3 Sophora flower 1 1.8 2

[0059] Comparative Examples 1-5

[0060] Comparative Examples 1-5 respectively provide a tranquilizing sleep-aiding composition of components as shown in Table 2, wherein each component in the tranquilizing sleep-aiding composition is in parts by weight.

[0061] Table 2: Composition of tranquilizing sleep-aiding compositions of Comparative Examples 1-5 (parts by weight)

[0062] Components Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Theanine -- 8 9 9 10 Ganoderma extract 2 -- 4 4 5 Gastrodia extract 2 2 -- 3 4 Piper methysticum extract 1 1 2 -- 3 Sophora flower 1 1 1.8 1.8 --

[0063] The method for preparing the tranquilizing sleep-aiding compositions of Examples 1-3 and Comparative Examples 1-5 comprises the following steps:

[0064] Weighing each component by proportion;

[0065] Mixing each component uniformly to obtain the tranquilizing sleep-aiding composition.

[0066] If there is Sophora japonica, first crush Sophora japonica to pass through an 80-mesh sieve, then mix it uniformly with the remaining components; pass through an 80-mesh sieve again, and then dry in an oven at 45°C for 15 min to obtain the tranquilizing sleep-aiding composition.

[0067] Effect verification

[0068] The tranquilizing sleep-aiding compositions prepared above are subjected to relevant tests. Among them, the test contents include two aspects of tranquilization and improvement of sleep quality.

[0069] Test method

[0070] Select 54 mice, male, body weight 25±2g; after 3 days of adaptability in the animal room, divide the 54 mice into 9 groups, 6 mice in each group, respectively blank control group (use normal saline), Example 1-3 groups (corresponding to use the tranquilizing sleep-aiding compositions of Examples 1-7), Comparative Example 1-5 groups (corresponding to use the tranquilizing sleep-aiding compositions of Comparative Examples 1-5).

[0071] Give the Example 1-3 groups and Comparative Example 1-5 groups the tranquilizing sleep-aiding compositions prepared by the corresponding groups (gavage administration); specifically, soak the tranquilizing sleep-aiding compositions prepared by each group and purified water (95°C) according to a solid-liquid ratio of 1:65g / mL, filter the residue after soaking for 5 min, and cool the liquid to room temperature, then gavage administration according to a dosage of 50mg / kg; give the blank control group the same dose of normal saline. Each group is given the drug once a day, and the mice in each group freely drink water and eat food; after 14 days of continuous gavage, 30 minutes after the last administration, each group is intraperitoneally injected with a dose of 40mg / kg of sodium pentobarbital, and the sleep latency (min) and sleep time (min) of the mice are observed and recorded.

[0072] Sleep latency is the time from administration to the disappearance of the righting reflex.

[0073] Sleep is measured by the disappearance of the righting reflex. When the mice are placed in a dorsal recumbent position, they can immediately turn over to a prone position. If they cannot turn over for more than 1 minute, it is considered that the righting reflex has disappeared, and the mice have entered sleep. The recovery of the righting reflex indicates that the animals are awake, and the time from the disappearance of the righting reflex to the recovery of the righting reflex is the sleep time of the animals. The test results are shown in Table 3.

[0074] Table 3: Test results of sleep latency and sleep time

[0075] Group Sleep latency (min) Sleep time (min) Blank control group 7.5±1.6 11.2±1.1 Example 1 3.3±0.6 31.5±1.6 Example 2 2.8±1.2 34.8±0.8 Example 3 3.0±0.7 33.2±1.3 Comparative Example 1 5.6±1.1 21.8±0.7 Comparative Example 2 5.1±0.8 20.6±1.1 Comparative Example 3 6.2±1.2 25.5±1.2 Comparative Example 4 6.1±1.3 26.3±1.4 Comparative Example 5 5.8±1.4 28±1.5

[0076] As shown in Table 3, the mice taking the compositions of Examples 1 to 3 significantly shortened the sleep latency and significantly prolonged the sleep duration. The compositions prepared in Examples 1 to 3 have the effect of treating insomnia. In comparison with Example 1, Comparative Examples 1 to 2 have a longer sleep latency and a shorter sleep duration, and the sleep duration is shortened more obviously, which indicates that the combination of theanine and ganoderma extract in the present application can better inhibit the nerve excitement, and at the same time, can enhance the regulation of the neurotransmitter system and protect the nerve cells, so as to improve the sleep quality and the sleep persistence. In comparison with Examples 2 and 3, Comparative Examples 3 to 5 have a longer sleep latency and a shorter sleep duration, and the sleep latency is relatively obviously longer, which indicates that the combination of the extract of ginkgo leaves, the extract of gnetum gnemon and the extract of sophora flower in the present application has a better calming and hypnotic effect, and thus can shorten the sleep latency.

Claims

1. A tranquilizing and sleep-inducing composition containing theanine, characterized in that: The invention comprises the following raw material components in parts by weight: 8-10 parts of theanine, 2-5 parts of ganoderma lucidum extract, 2-4 parts of bamboo leaf extract, 1-3 parts of macrophylla extract and 1-2 parts of sophora japonica flower.

2. A theanine-containing tranquilizing and sleep-inducing composition according to claim 1, characterized in that: The invention comprises the following raw material components in parts by weight: 9 parts of theanine, 4 parts of ganoderma lucidum extract, 3 parts of bamboo leaf extract, 2 parts of macrophylla extract and 1.8 parts of sophora japonica flower.

3. The method for preparing a theanine-containing tranquilizing and sleep-inducing composition according to claim 1 or 2, characterized in that: The preparation method comprises the following steps: crushing and sieving Sophora japonica flower, uniformly mixing the mixture with theanine, Ganoderma lucidum extract, Bambusa chinensis leaf extract and Acanthus macrophylla extract, and sieving the mixture again to obtain the tranquilizing and sleep-inducing composition.

4. Use of the composition according to claim 1 or 2 in preparing a nutritional product for improving sleep quality.

5. The use according to claim 4, characterized in that The nutritional product is in the form of powder, granules, tablets or solutions.

6. The use according to claim 4, characterized in that The nutritional product also includes auxiliary materials.