Rapid lymphatic vein communication device for continuous drainage

Abstract

The rapid lymphatic vein communication device comprises an elastic tube body, notches which are symmetrical left and right are formed in the front end of the tube body, the notches are in the shape with the large front portion and the small rear portion, the tube thickness of the notch areas is sequentially decreased from back to front, the section of the tube body is in an oval shape, and the section of the tube body is in an oval shape. The upper end and the lower end of the tube body are provided with sheet-shaped protrusions on the right side of the notch, and lymphatic vessel generation promoting factors are embedded or coated on the tube wall of the tube body. According to the invention, lymphatic tissues and veins can be communicated efficiently and quickly; blood reflux and thrombosis are avoided; sewing operation is not needed or reduced; blood vessel blocking is not needed; specific growth factors contained in the kit can promote the generation of normal lymph lumen, form autologous biological lumen in the later period, and maintain long-term smoothness.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of lymphatic drainage devices, in particular to a rapid lymphatic vein communication device for continuous drainage. BACKGROUND

[0002] Lymphedema is often seen in secondary lymphatic circulation disorders caused by breast cancer, cervical cancer surgery or filariasis, etc., which is manifested as limb swelling, fibrosis and increased risk of infection. Traditional conservative treatment (such as compression therapy, physiotherapy) can only temporarily relieve symptoms and cannot solve the problem of lymphatic vessel structure damage.

[0003] In recent years, research has found that Alzheimer's disease and some brain functional diseases may be related to lymphatic backflow disorders. Lymphatic vein anastomosis (LVA) can improve brain lymphatic drainage, reduce beta-amyloid deposition, and delay the progression of Alzheimer's disease, becoming a new direction for its treatment.

[0004] With the progress of microsurgery, the maturation of ultramicro technology (operating lymphatic vessels / veins with a diameter of 0.2-0.6mm) makes precise anastomosis possible. At the same time, the innovation of imaging technology also provides support for this technology, indocyanine green (ICG) fluorescence imaging and magnetic resonance lymphangiography (MRL) achieve preoperative lymphatic vessel positioning, which significantly improves the success rate of surgery.

[0005] However, the communication between lymphatic tissue and venous system can promote the backflow and excretion of lymphatic fluid, but the fluid composition in the above two tissues is different, and blood backflow is easy to form thrombosis and blockage, with low success rate. Traditional operation requires incision of the vein for microsuture, which is very high in technical requirements, time-consuming and bleeding. At the same time, it needs to block the original vein to cause blood stasis in the corresponding part. SUMMARY

[0006] The purpose of the present application is to provide a rapid lymphatic vein communication device for continuous drainage to solve the above technical problems.

[0007] The above technical purpose of the present application is realized by the following technical scheme: A rapid lymphatic vein communication device for continuous drainage, comprising an elastic tube body, a left-right symmetrical notch is formed at the front end of the tube body, the notch is large in front and small in back, the tube thickness of the notch area decreases from back to front, the cross section of the tube body is oval, a sheet-shaped protrusion is arranged at the right side of the notch at the upper and lower ends of the tube body, and a lymphangiogenic factor is embedded or coated on the tube wall of the tube body.

[0008] By adopting the technical scheme, the one end of the pipe body with the notch can be inserted into the vein, and the pipe body is in an open state when the external pressure is negative pressure, and the two sheet-shaped structures are mutually closed when the external pressure is positive pressure, thereby forming a one-way anti-reflux state of negative pressure open and positive pressure closed, so that blood reflux and thrombosis are avoided.

[0009] Further provided by the application is that the length of the notch is 4-6 times of the pipe diameter of the pipe body.

[0010] Further provided by the application is that the outer diameter of the pipe body is 1-10 mm, and the wall thickness of the pipe body is 0.2-1 mm.

[0011] Further provided by the application is that the lymphangiogenesis factor is vascular endothelial growth factor-C.

[0012] By adopting the technical scheme, the normal lymphatic vessel cavity can be promoted to be generated, and the self biological cavity is formed in the later period, so that long-term patency is maintained.

[0013] Further provided by the application is that the cross section of the pipe body is an ellipse with an eccentricity of 0.1-0.3.

[0014] Further provided by the application is that the material of the pipe body is any one or a plurality of materials such as silicone rubber, PVC or cellulose fiber weaving.

[0015] Further provided by the application is that the puncture sheath is further provided, the puncture sheath is in a tubular shape with a pointed end, and the diameter of the puncture sheath can allow the pipe body and the sheet-shaped protrusion to be inserted.

[0016] By adopting the technical scheme, the left end of the pipe body can be smoothly inserted into the vein.

[0017] In summary, the application has the following beneficial effects: Firstly, the application can efficiently and quickly connect the lymphatic tissue and the vein, avoid blood reflux and thrombosis, reduce or eliminate the suturing operation, and does not need to block the blood vessel.

[0018] Secondly, the application has higher drainage efficiency, and the neck vein is in a positive and negative pressure fluctuation state with the respiratory movement, the negative pressure period promotes the reflux, the positive pressure period weakens the reflux or even causes the reflux. BRIEF DESCRIPTION OF DRAWINGS

[0019] Fig. 1 is the schematic diagram of the whole structure of the present application; Fig. 2 is the sectional view (closed state) in the present application; Fig. 3 is the sectional view of the tube body in the present application.

[0020] In the figure: 1, tube body; 2, notch; 3, sheet-shaped protrusion; 4, puncture sheath. DETAILED DESCRIPTION

[0021] The present application will be further described in detail below with reference to the accompanying drawings.

[0022] In the description of the present application, it should be understood that the terms "upper", "lower", "left", "right", "front", "back", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and therefore cannot be understood as indicating or implying that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application.

[0023] In addition, the terms "horizontal", "vertical" and the like do not mean that the components must be absolutely horizontal or vertical, but can be slightly inclined. For example, "horizontal" only means that its direction is more horizontal relative to "vertical", and does not mean that the structure must be completely horizontal, but can be slightly inclined.

[0024] In the description of the present application, it should be noted that unless otherwise explicitly specified and limited, the terms "provided", "connected", "connected" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, it can be directly connected, or indirectly connected through an intermediate medium, it can be the communication between the two elements inside. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0025] Embodiment, a quick lymphatic vein communication device for continuous drainage, as shown in Figs. 1 to 3As shown, it comprises a tube body 1 with elasticity, a left end of the tube body 1 is provided with a left-right symmetrical notch 2, the notch 2 is large in front and small in back, and the tube thickness of the notch 2 area decreases from back to front. Due to its own elasticity, the left end of the tube body 1 is in an open state when the external pressure is negative, and the two sheet structures are mutually closed when the external pressure is positive, forming a one-way anti-reflux state of negative pressure opening and positive pressure closing. The length of the notch 2 is 4-6 times the diameter of the tube body 1, of course, in this embodiment, it is 5 times, of course, it can also be 4 times or 6 times. The cross section of the tube body 1 is an ellipse with an eccentricity of 0.1-0.3, in this embodiment, the eccentricity is 0.2, of course, it can also be 0.1 or 0.3, which does not affect the protection scope of the present application. When the tube body 1 is inserted into the vein with negative pressure at one end, the internal liquid is discharged, and at the same time, due to its own elastic tube cavity, the tube cavity will be reduced, and the eccentricity will increase; when the tube body 1 is inserted into the vein with positive pressure at one end, the tube cavity is still under negative pressure, and with the recovery of the tube cavity shape, the attraction to the rear end is sustained, and the tube cavity in this area functions as a liquid storage bag. To the next breathing cycle, the head end is opened after the venous pressure decreases, and enters the next cycle. The outer diameter of the tube body 1 is 1-10 mm, and the wall thickness of the tube body 1 is 0.2-1 mm. In this embodiment, the outer diameter of the tube body 1 is 7 mm, of course, it can also be 1 mm, 10 mm or any value between 1-10 mm, the wall thickness of the tube body 1 is 0.7 mm, it can also be 0.2 mm, 1 mm or any value between 0.2-1 mm, of course, the specific specifications can be set according to the specific situation of the patient. The upper and lower ends of the tube body 1 are provided with sheet-shaped protrusions 3 on the right side of the notch 2, the sheet-shaped protrusions 3 can be penetrated by a suture needle and have a certain toughness, which is convenient for suture fixation with veins, lymph and other tissues. The tube wall of the tube body 1 is embedded or coated with a lymphangiogenesis factor, the lymphangiogenesis factor is vascular endothelial growth factor-C (VEGF-C), which can promote the generation of normal lymphatic cavities, and form autologous biological cavities in the later stage, maintaining long-term patency.

[0026] Vascular endothelial growth factor-C (VEGF-C) is a dimeric secreted protein, its main function is to promote the formation of lymphatic vessels. It mainly acts on lymphatic endothelial cells through its receptor VEGFR-3, promotes the survival, growth and migration of lymphatic endothelial cells, and is a specific growth factor for lymphatic vessels in various models. At the same time, VEGF-C can also induce physiological and intratumoral neovascularization and vascular sprouting by interacting with VEGFR2. Materials such as polycaprolactone (PCL), chitosan, etc. can be combined with VEGF-C protein to prepare special slow-release coatings through ion precipitation-coagulation method, electrospinning method, etc. Combined with the material of the device through coating or embedding. Slowly release VEGF-C after the device is implanted in the body and connected with lymph and veins, promote the growth of venous and lymphatic endothelium, and finally form a natural lymphatic venous pipeline bridge in the device. The self-grown structure can ensure the long-term patency of the pathway and avoid the adverse effects of the implant on the body.

[0027] The length of the tube body 1 is not limited and can be set longer. During use, it can be trimmed according to actual needs.

[0028] The material of the tube body 1 is any one or a combination of multiple materials such as silicone rubber, PVC or cellulose fiber weaving.

[0029] The device also includes a puncture sheath 4, which is a tubular structure with a sharp end. The diameter of the puncture sheath allows the tube body 1 and the sheet-shaped protrusion 3 to be inserted.

[0030] During use, an incision is made near the lymphatic vessels and veins in the neck, and the veins and lymphatic vessels are separated under a microscope. First, the puncture sheath 4 is inserted into the vein with the sharp end facing the heart direction. Then, the tube body 1 is inserted into the puncture sheath 4 and introduced into the vein. After completion, the puncture sheath 4 is withdrawn and finally not left in the body. Adjust the length of the tube body 1 entering the vein and the length required for the tube body 1 to connect with the lymphatic tissue. Then, the lymphatic tissue is connected with the tube body 1 (sleeved or anastomosed), and finally the vein and lymphatic tissue (tube, node or valve) are sutured and fixed to the corresponding position of the sheet-shaped protrusion 3 or the tube body 1. Only 1-3 stitches are required at each end, which is less than the number of stitches required by traditional anastomosis methods and has lower difficulty. This process does not require blood vessel blockage and has very little bleeding.

[0031] The specific embodiments are only an explanation of the present application, which is not a limitation of the present application. Those skilled in the art can make modifications to the embodiments without creative contribution after reading the specification, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. A quick lymphatic-venous shunt for continuous drainage, characterized by: The application relates to a lymphatic vessel promoting tube, which comprises a tube body (1) with elasticity, wherein the front end of the tube body (1) is provided with left-right symmetrical notches (2), the notches (2) are in a shape of being large in front and small in back, the tube thickness of the notch (2) area is sequentially reduced from back to front, the cross section of the tube body (1) is in an oval shape, the upper and lower ends of the tube body (1) are provided with sheet-shaped protrusions (3) on the right side of the notch (2), and a lymphatic vessel promoting factor is embedded or coated on the tube wall of the tube body (1).

2. The quick lymphatic-venous shunt device for sustained drainage according to claim 1, characterized in that: The length of the notch (2) is 4-6 times of the tube diameter of the tube body (1).

3. A quick lymphatic venous connection device for sustained drainage according to claim 2, characterized in that: The outer diameter of the tube body (1) is 1-10 mm, and the wall thickness of the tube body (1) is 0.2-1 mm.

4. A quick lymphatic venous connection device for persistent drainage according to claim 3, characterized in that: The lymphatic vessel promoting factor is a vascular endothelial growth factor-C.

5. A quick lymphatic venous connection device for persistent drainage according to claim 4, characterized in that: The cross section of the tube body (1) is in an oval shape with an eccentricity of 0.1-0.

3.

6. A quick lymphatic venous connection device for persistent drainage according to claim 5, characterized in that: The material of the tube body (1) is any one or a plurality of composite materials of silicon rubber, PVC or cellulose fiber weaving.

7. A quick lymphatic venous connection device for persistent drainage according to claim 6, characterized in that: The application further relates to a puncture sheath (4), which is in a tubular shape with a pointed end at one end, and the diameter of the puncture sheath (4) can allow the tube body (1) and the sheet-shaped protrusions (3) to be inserted.

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