Acne-removing, oil-controlling and itching-relieving composition and preparation method thereof

Abstract

The invention relates to an acne-removing, oil-controlling and itching-relieving composition and a preparation method thereof.The acne-removing, oil-controlling and itching-relieving composition is prepared from water, butanediol, a tuber melanosporum extract, a black willow bark extract and a black mulberry extract.The preparation method includes the steps that the water and the butanediol are added into a reaction kettle, stirred to be uniform and heated to 65 DEG C, and the butanediol is completely dissolved in the water; sequentially adding a tuber melanosporum extract, a black willow bark extract, a black mulberry fruit extract, a lactobacillus / rye fine powder fermentation product, a rye seed extract and a ganoderma atrum extract into the water phase obtained in the step 1, uniformly stirring, keeping the temperature at 60 DEG C, and stirring for 40 minutes, so that the extracts are fully dissolved and dispersed. The acne-removing oil-controlling itching-relieving lotion has the effects of removing acnes, controlling oil and relieving itching, can comprehensively solve common skin problems, provides a one-stop skin care solution for consumers, is mainly prepared from natural plant extracts and fermentation products, is small in skin irritation, and is suitable for various skin types, especially sensitive skin.

Description

Technical Field

[0001] This invention relates to the field of daily chemical technology, specifically to an acne-removing, oil-controlling, and itch-relieving composition and its preparation method. Background Technology

[0002] With the ever-accelerating pace of modern life, people face pressure from work, life, and other aspects. At the same time, diets are becoming increasingly diversified, often favoring high-sugar, high-fat, and spicy foods. These factors combined have led to a rise in skin problems, with acne, excessive sebum production, and itchy skin troubling many people.

[0003] Products on the market for treating itchy skin mainly include anti-itch creams and lotions. For example, Chinese Patent 202411083286.4 discloses an oil-controlling and anti-itch composition containing natural active ingredients, its preparation method, and its application. It uses ethanol and water for temperature-controlled extraction to effectively extract the volatile or water-insoluble active ingredients of traditional Chinese medicine raw materials, thereby synergistically enhancing the effects of the active ingredients.

[0004] However, these products often relieve itching symptoms through anti-inflammatory, anti-allergic, or local anesthetic effects. However, some anti-itch products are not very effective and may contain hormones or other ingredients, which can lead to dependence and other side effects with long-term use.

[0005] Therefore, developing a safe, effective composition that can simultaneously address acne treatment, oil control, and itch relief has broad market prospects and significant social implications. Summary of the Invention

[0006] To address the shortcomings of existing technologies, this invention provides an acne-removing, oil-controlling, and itch-relieving composition and its preparation method. This composition can effectively remove acne, control oil, and relieve itching. It is also made of natural ingredients and has low skin irritation, thus meeting consumers' skin care needs.

[0007] To achieve the above objectives, the present invention provides the following technical solution: a composition for acne treatment, oil control, and itch relief, characterized in that it comprises the following components by weight percentage:

[0008] Water: 80-90%;

[0009] Butylene glycol: 8-12%;

[0010] TUBER MELANOSPORUM extract: 0.005-0.015%;

[0011] Black willow (SALIXNIGRA) bark extract: 0.03-0.07%;

[0012] Black mulberry (MORUSNIGRA) fruit extract: 1.5-2.5%;

[0013] Lactobacillus / rye flour fermentation products: 0.3-0.7%;

[0014] Rye (SECALE CEREALE) seed extract: 0.1-0.3%;

[0015] Black Ganoderma Atraum Extract: 0.3-0.7%;

[0016] o-Cymenocyanate-5-ol: 0.05-0.15%;

[0017] 1,2-Hexanediol: 0.3-0.7%;

[0018] p-Hydroxyacetophenone: 0.3-0.7%.

[0019] Preferably, the *Tuber nigricans* extract is used to exert antioxidant and anti-inflammatory effects to reduce inflammation caused by acne; the *Salix matsudana* bark extract utilizes its natural tannins and flavonoids to have astringent and antibacterial effects, reducing sebum secretion and inhibiting the growth of bacteria that cause acne, such as *Propionibacterium acnes*.

[0020] Preferably, the black mulberry extract, with its rich vitamins, minerals and anthocyanins, achieves antioxidant, anti-inflammatory and sebum-regulating functions, while the lactobacillus / rye flour fermentation product is used to regulate the skin's microbial flora balance and enhance the skin's barrier function.

[0021] Preferably, the rye seed extract, through its rich dietary fiber and bioactive components, regulates skin metabolism and improves skin health; the black Ganoderma lucidum extract exerts anti-inflammatory, antioxidant, and immunomodulatory effects, relieves skin itching, and promotes skin repair.

[0022] Preferably, the o-cymene-5-ol is used for antibacterial and anti-inflammatory purposes to inhibit acne formation; 1,2-hexanediol and p-hydroxyacetophenone are used as preservatives to ensure the stability and safety of the composition and extend its shelf life.

[0023] Preferably, the composition can be prepared into various dosage forms, including but not limited to lotions, creams, gels, toners, and facial mask essences.

[0024] A method for preparing an acne-removing, oil-controlling, and itch-relieving composition, characterized by comprising the following steps:

[0025] Step 1: Aqueous phase preparation. Add water and butanediol to the reaction vessel, stir evenly, and heat to 60-70℃ to completely dissolve the butanediol in the water.

[0026] Step 2: Adding extracts. Add the following extracts in sequence to the aqueous phase obtained in Step 1: Black Truffle extract, Black Willow bark extract, Black Mulberry fruit extract, Lactobacillus / Rye flour fermentation product, Rye seed extract, and Black Ganoderma extract. Stir well and maintain the temperature at 55-65℃ for 30-45 minutes to ensure the extracts are fully dissolved and dispersed.

[0027] Step 3: Add active ingredients. Add o-cymene-5-ol to the mixture obtained in Step 2 and continue stirring for 15-20 minutes to ensure uniform distribution of the active ingredients.

[0028] Step 4: Add preservatives. When the mixture obtained in Step 3 has cooled to 40-45℃, add 1,2-hexanediol and p-hydroxyacetophenone, and stir until homogeneous.

[0029] Step 5: Filtration and filling. The composition obtained in Step 4 is filtered through a 0.22 μm microporous membrane to remove impurities and insoluble particles, and then filled into a suitable container.

[0030] Furthermore, the heating temperature in step one can be adjusted within the range of 55-75℃, the temperature in step two can be adjusted within the range of 50-70℃, and the stirring time can be adjusted within the range of 25-50 minutes.

[0031] Furthermore, the stirring time in step three can be adjusted within the range of 10-25 minutes, and the cooling temperature in step four can be adjusted within the range of 35-50℃. Even within these parameter adjustment ranges, a composition with acne-removing, oil-controlling, and itch-relieving effects can still be prepared.

[0032] Compared with the existing technology, the technical solution of this application has the following beneficial effects:

[0033] 1. Multiple benefits in one: This combination has the effects of acne removal, oil control and itch relief, which can comprehensively solve common skin problems and provide consumers with a one-stop skin care solution.

[0034] 2. Natural and safe ingredients: The main ingredients are derived from natural plant extracts and fermentation products, which are less irritating to the skin and suitable for all skin types, especially sensitive skin.

[0035] 3. Synergistic Effect: The components work together to exert a stronger effect than a single component. For example, the antibacterial effect of black willow bark extract combined with the antibacterial and anti-inflammatory effect of o-cymene-5-ol can more effectively inhibit the formation of acne; the antioxidant and sebum-regulating effects of black mulberry fruit extract combined with the anti-inflammatory and immunomodulatory effects of black Ganoderma lucidum extract help improve the overall health of the skin. Attached Figure Description

[0036] Figure 1 This is a flowchart illustrating the preparation method of the acne-removing, oil-controlling, and itch-relieving composition of the present invention.

[0037] Figure 2 This is a line graph showing the changes in the acne-removing effects of different groups of the present invention over time.

[0038] Figure 3 This is a line graph showing the change in oil control effect of different groups of the present invention over time;

[0039] Figure 4 This is a line graph showing the change in the antipruritic effect of different groups of the present invention over time. Detailed Implementation

[0040] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0041] Example 1: A standard-formulation composition for acne treatment, oil control, and itch relief.

[0042] Please refer to Figure 1 A composition for treating acne, controlling oil, and relieving itching, and its preparation method, are implemented as follows:

[0043] 1. Ingredient preparation

[0044] Prepare each ingredient according to the following weight percentages:

[0045] Water: 85.64kg

[0046] Butylene glycol: 10kg

[0047] TUBER MELANOSPORUM extract: 0.01kg

[0048] Black willow (SALIXNIGRA) bark extract: 0.05kg

[0049] Black mulberry (MORUSNIGRA) fruit extract: 2kg (added in two batches of 1kg each time)

[0050] Lactobacillus / rye flour fermentation product: 0.5kg

[0051] Rye (Seclare Cereus) Seed Extract: 0.2kg

[0052] Black Ganoderma Atraum Extract: 0.5kg

[0053] o-Cymenyl-5-ol: 0.1 kg

[0054] 1,2-Hexanediol: 0.5 kg

[0055] p-Hydroxyacetophenone: 0.5 kg

[0056] 2. Preparation process

[0057] Aqueous phase preparation: In a suitable-sized reactor, add 85.64 kg of water and 10 kg of butanediol. Turn on the stirrer to ensure the water and butanediol are thoroughly mixed. Then, slowly heat to 65°C and continue stirring until the butanediol is completely dissolved in the water.

[0058] Extract addition: 0.01 kg of *Ichthyophthirius multifiliis* extract, 0.05 kg of *Ichthyophthirius multifiliis* bark extract, 2 kg of *Ichthyophthirius multifiliis* fruit extract, 0.5 kg of *Lactobacillus* / rye flour fermentation product, 0.2 kg of rye seed extract, and 0.5 kg of *Ganoderma lucidum* extract were added sequentially to the aqueous phase above. The temperature was maintained at 60°C, and the mixture was stirred continuously for 40 minutes to ensure that all extracts were fully dissolved and uniformly dispersed in the aqueous phase.

[0059] Addition of active ingredients: Add 0.1 kg of o-cymene-5-ol to the mixture and continue stirring for 18 minutes to ensure that the active ingredients are evenly distributed throughout the system.

[0060] Preservative addition: When the mixture has cooled naturally to 42°C, add 0.5 kg of 1,2-hexanediol and 0.5 kg of p-hydroxyacetophenone, stir well to ensure that the preservative is fully dissolved and can play its role.

[0061] Filtration and Filling: The obtained composition was filtered using a 0.22μm microporous membrane to remove any impurities and insoluble particles. The filtered composition was then filled into pre-sterilized suitable containers to obtain the standard-formulated acne-reducing, oil-controlling, and itch-relieving composition.

[0062] Example 2: Acne-reducing, oil-controlling, and anti-itch composition with adjusted ingredient ratios

[0063] 1. Ingredient preparation

[0064] Adjust the weight percentage of each component as follows:

[0065] Water: 88kg

[0066] Butylene glycol: 9kg

[0067] TUBER MELANOSPORUM extract: 0.012 kg

[0068] Black willow (SALIXNIGRA) bark extract: 0.06kg

[0069] Black mulberry (MORUSNIGRA) fruit extract: 2.2kg (added in two doses of 1.1kg each time)

[0070] Lactobacillus / rye flour fermentation product: 0.6 kg

[0071] Rye (Seclare Cereus) Seed Extract: 0.25kg

[0072] Black Ganoderma Atraum Extract: 0.6kg

[0073] o-Cymenocyanate-5-ol: 0.12 kg

[0074] 1,2-Hexanediol: 0.6 kg

[0075] p-Hydroxyacetophenone: 0.6 kg

[0076] 2. Preparation process

[0077] Aqueous phase preparation: Add 88 kg of water and 9 kg of butanediol to the reactor, stir well, and heat to 68°C until the butanediol is completely dissolved.

[0078] Adding extracts: Add the appropriate amounts of each extract in sequence, keep the temperature at 62℃, and stir for 42 minutes.

[0079] Addition of active ingredients: Add 0.12 kg of o-cymene-5-ol and stir for 20 minutes.

[0080] Preservative addition: When cooled to 43°C, add 0.6 kg of 1,2-hexanediol and 0.6 kg of p-hydroxyacetophenone, and stir until homogeneous.

[0081] Filtration and filling: After filtration through a 0.22μm microporous membrane, the mixture is filled to obtain an acne-removing, oil-controlling, and itch-relieving composition with adjusted ingredient ratios.

[0082] Example 3: Acne-reducing, oil-controlling, and anti-itch compositions in different dosage forms

[0083] 1. Emulsion formulation

[0084] Based on the preparation in Example 1, after the preservative addition step and thorough stirring, a suitable amount of emulsifier (such as glyceryl stearate, polysorbate-80, etc.) is slowly added, and stirring continues until the system is completely emulsified. Depending on the required emulsion consistency, a thickener (such as carbomer) can be added as needed to adjust the consistency, ultimately yielding an acne-reducing, oil-controlling, and itch-relieving emulsion.

[0085] 2. Face cream formulation

[0086] Based on the preparation process of Example 1, after adding the preservative and stirring evenly, more oil components (such as petrolatum, lanolin, etc.) are added to increase the proportion of the oil phase in the system. The oil is fully melted and evenly mixed with the aqueous phase by heating and stirring, and then slowly cooled while stirring continuously. After cooling to room temperature, a paste-like texture is formed, thus obtaining the acne-reducing, oil-controlling, and anti-itch face cream.

[0087] 3. Gel formulation

[0088] After the aqueous phase preparation is complete, an appropriate amount of gel matrix (such as hydroxypropyl methylcellulose, xanthan gum, etc.) is added and stirred to allow it to swell fully. Subsequently, the extract, active ingredient, and preservative are added sequentially according to the steps in Example 1. Finally, the pH value of the system is adjusted to a suitable range to obtain an acne-reducing, oil-controlling, and anti-itch gel.

[0089] Example 4: Acne-reducing, oil-controlling, and anti-itch composition prepared by adjusting method parameters

[0090] 1. Ingredient preparation

[0091] Same component weights as in Example 1.

[0092] 2. Preparation process

[0093] Aqueous phase preparation: Add water and butanediol to the reaction vessel, stir evenly, and heat to 72℃ (within the range of 55-75℃) to dissolve the butanediol.

[0094] Adding extracts: Add various extracts, maintain the temperature at 68℃ (within the range of 50-70℃), and stir for 35 minutes (within the range of 25-50 minutes).

[0095] Add active ingredient: Add o-cymene-5-ol and stir for 13 minutes (adjust within the range of 10-25 minutes).

[0096] Preservative addition: When cooled to 48℃ (within the range of 35-50℃), add 1,2-hexanediol and p-hydroxyacetophenone, and stir until homogeneous.

[0097] Filtration and filling: The mixture is filtered and filled to obtain the acne-removing, oil-controlling, and itch-relieving composition after the preparation method parameters have been adjusted.

[0098] Clinical trial example

[0099] I. Experimental Objective

[0100] The efficacy, safety, and tolerability of the acne-removing, oil-controlling, and itch-relieving composition of the present invention in practical applications were evaluated.

[0101] II. Experimental Subjects

[0102] Three hundred volunteers aged 18-45 years with varying degrees of acne, excessive sebum secretion, or itchy skin were selected. The volunteers were randomly divided into three groups: an experimental group (using the acne-reducing, oil-controlling, and itch-relieving composition of this invention), a positive control group (using a well-known brand of acne-reducing, oil-controlling, and itch-relieving product on the market), and a negative control group (using a base product without active ingredients), with 100 participants in each group.

[0103] Inclusion criteria: Acne on the face or body with at least 5 pimples, excessive sebum secretion, noticeable oiliness in the T-zone or other areas, itchy skin symptoms occurring at least 3 times a week, willingness to participate in the experiment, and signing of an informed consent form.

[0104] Exclusion criteria: Individuals allergic to any of the ingredients in the experimental product, those currently using other medications or skincare products that may affect the experimental results, and those suffering from severe systemic diseases or skin conditions.

[0105] III. Experimental Products

[0106] Experimental group: The acne-removing, oil-controlling, and itch-relieving composition prepared in Example 1 was used for daily skin care according to the product instructions.

[0107] Positive control group: Used a well-known brand of acne-removing, oil-controlling, and anti-itch product on the market, according to its instructions.

[0108] Negative control group: A matrix product without active ingredients was used, which had a similar appearance and texture to the experimental group product and was used in the same manner as the experimental group.

[0109] IV. Experimental Methods

[0110] Before the experiment began, all volunteers had their skin condition assessed by professionals, including the number, size, and degree of inflammation of pimples, the amount of sebum secreted by the skin (measured using a sebum analyzer), and the frequency and severity of itching symptoms (using a visual analog scale, with 0 points for no itching and 10 points for extreme itching).

[0111] Volunteers cleansed their skin every morning and evening and then applied the corresponding experimental products for eight weeks.

[0112] During the experiment, volunteers need to maintain normal daily routines and eating habits, avoid eating spicy, greasy or other irritating foods, and record situations that may affect the experimental results, such as using other skin care products or taking medication when sick.

[0113] The volunteers' skin condition was assessed and data were recorded in weeks 2, 4, 6 and 8.

[0114] 5. Experimental Results

[0115] (I) Acne Treatment Effect

[0116]

[0117] The experimental group showed a significantly higher average reduction in the number of pimples at week 8 compared to the positive and negative control groups, indicating that the composition of the present invention has a better acne-removing effect.

[0118] (II) Oil control effect

[0119]

[0120]

[0121] The average reduction in sebum secretion in the experimental group was significantly higher than that in the positive and negative control groups, indicating that the oil-controlling effect of the composition of the present invention is more significant.

[0122] (III) Antipruritic effect

[0123]

[0124]

[0125] The itch relief rate in the experimental group was much higher than that in the positive and negative control groups, indicating that the composition of the present invention has a significant antipruritic effect.

[0126] (iv) Safety and tolerability

[0127] During the experiment, three volunteers in the experimental group experienced mild skin redness, but this did not affect their continued use and the symptoms subsided spontaneously within 1-2 days, with an adverse reaction rate of 3%. In the positive control group, eight volunteers experienced adverse reactions such as dry skin and peeling, with an incidence rate of 8%. No adverse reactions were observed in the negative control group. This indicates that the composition of the present invention has good safety and tolerability.

[0128] VI. Experimental Conclusions

[0129] Clinical trials have fully demonstrated that the acne-removing, oil-controlling, and itch-relieving composition of this invention has significant effects in acne removal, oil control, and itch relief, and is superior to similar products on the market. Furthermore, this composition is highly safe, well-tolerated, and suitable for a wide range of people with related skin problems, possessing broad market application prospects.

[0130] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply the existence of any such actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article, or device comprising a series of elements includes not only those elements, but also other elements not explicitly listed, or elements inherent to such process, method, article, or device. In the absence of further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of other identical elements in the process, method, article, or device comprising the element.

[0131] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A composition for treating acne, controlling oil production, and relieving itching, characterized in that, By weight percentage, it contains the following ingredients: Water: 80-90%; Butylene glycol: 8-12%; TUBER MELANOSPORUM extract: 0.005-0.015%; Black willow (SALIXNIGRA) bark extract: 0.03-0.07%; Black mulberry (MORUSNIGRA) fruit extract: 1.5-2.5%; Lactobacillus / rye flour fermentation products: 0.3-0.7%; Rye (SECALE CEREALE) seed extract: 0.1-0.3%; Black Ganoderma Atraum Extract: 0.3-0.7%; o-Cymenocyanate-5-ol: 0.05-0.15%; 1,2-Hexanediol: 0.3-0.7%; p-Hydroxyacetophenone: 0.3-0.7%.

2. The acne-removing, oil-controlling, and itch-relieving composition according to claim 1, characterized in that, The *Tuber spores* extract is used to exert antioxidant and anti-inflammatory effects to reduce inflammation caused by acne; the black willow bark extract utilizes its natural tannins and flavonoids to have astringent and antibacterial effects, reducing sebum secretion and inhibiting the growth of bacteria that cause acne, such as *Propionibacterium acnes*.

3. The acne-removing, oil-controlling, and itch-relieving composition according to claim 1, characterized in that, The black mulberry extract, rich in vitamins, minerals, and anthocyanins, has antioxidant, anti-inflammatory, and sebum-regulating functions. The lactobacillus / rye flour fermentation product is used to regulate the skin's microbiome balance and enhance the skin's barrier function.

4. The acne-removing, oil-controlling, and anti-itch composition and its preparation method according to claim 1, characterized in that, The rye seed extract, through its rich dietary fiber and bioactive components, regulates skin metabolism and improves skin health; the black Ganoderma lucidum extract exerts anti-inflammatory, antioxidant, and immunomodulatory effects, relieves skin itching, and promotes skin repair.

5. The acne-removing, oil-controlling, and itch-relieving composition according to claim 1, characterized in that, The o-cymene-5-ol is used for antibacterial and anti-inflammatory purposes, inhibiting acne formation; 1,2-hexanediol and p-hydroxyacetophenone are used as preservatives to ensure the stability and safety of the composition and extend its shelf life.

6. The acne-removing, oil-controlling, and itch-relieving composition according to claim 1, characterized in that, The composition can be prepared into various dosage forms, including but not limited to lotions, creams, gels, toners, and facial mask essences.

7. A method for preparing the acne-removing, oil-controlling, and itch-relieving composition according to any one of claims 1-6, characterized in that, Includes the following steps: Step 1: Aqueous phase preparation. Add water and butanediol to the reaction vessel, stir evenly, and heat to 60-70℃ to completely dissolve the butanediol in the water. Step 2: Adding extracts. Add the following extracts in sequence to the aqueous phase obtained in Step 1: Black Truffle extract, Black Willow bark extract, Black Mulberry fruit extract, Lactobacillus / Rye flour fermentation product, Rye seed extract, and Black Ganoderma extract. Stir well and maintain the temperature at 55-65℃ for 30-45 minutes to ensure the extracts are fully dissolved and dispersed. Step 3: Add active ingredients. Add o-cymene-5-ol to the mixture obtained in Step 2 and continue stirring for 15-20 minutes to ensure uniform distribution of the active ingredients. Step 4: Add preservatives. When the mixture obtained in Step 3 has cooled to 40-45℃, add 1,2-hexanediol and p-hydroxyacetophenone, and stir until homogeneous. Step 5: Filtration and filling. The composition obtained in Step 4 is filtered through a 0.22 μm microporous membrane to remove impurities and insoluble particles, and then filled into a suitable container.

8. The preparation method of the acne-removing, oil-controlling, and itch-relieving composition according to claim 1, characterized in that, In step one, the heating temperature can be adjusted within the range of 55-75℃, in step two the temperature can be adjusted within the range of 50-70℃, and the stirring time can be adjusted within the range of 25-50 minutes.

9. The preparation method of the acne-removing, oil-controlling, and itch-relieving composition according to claim 1, characterized in that, The stirring time in step three can be adjusted within the range of 10-25 minutes, and the cooling temperature in step four can be adjusted within the range of 35-50℃. Within these parameter adjustment ranges, a composition with acne-removing, oil-controlling, and itch-relieving effects can still be prepared.

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