Device for treating osteoporosis by combining electromagnetic field and ultrasonic wave with desumab

Abstract

The invention discloses a device for treating osteoporosis by compounding electromagnetic field and ultrasonic wave with Disumab, which comprises a base plate, a support bed mattress plate is fixedly mounted on the upper surface of the base plate, a limiting groove is formed in the base plate, and a transmission assembly is movably arranged in the limiting groove. A medicine conveying module, an electromagnetic field generating module and an ultrasonic wave generating module are fixedly arranged on the surface of the transmission assembly, the medicine conveying module, the electromagnetic field generating module and the ultrasonic wave generating module are electrically connected with an external control module, and a display interaction module is arranged in the external control module; the electromagnetic field, ultrasonic waves and medicine assistance are combined, the synergistic effect of multiple treatment means is achieved, the treatment effect on osteoporosis is improved, and compared with a single treatment mode, the bone mineral density can be more rapidly and effectively increased, and the treatment period can be shortened.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a device for treating osteoporosis using a combination of electromagnetic field, ultrasound, and denosumab. Background Technology

[0002] Osteoporosis is a systemic skeletal disease characterized by decreased bone mass and destruction of bone microstructure, leading to increased bone fragility and susceptibility to fractures. With the increasing aging of the global population, the incidence of osteoporosis is rising annually, seriously affecting the quality of life and health of the elderly. Currently, denosumab, as a novel anti-osteoporosis drug, specifically binds to the receptor activator of nuclear factor κB (RANKL), inhibiting the generation, function, and survival of osteoclasts, thereby reducing bone resorption and increasing bone density, achieving good results in the treatment of osteoporosis. However, the use of denosumab alone has limitations such as limited drug absorption efficiency and imprecise targeting, resulting in a long treatment cycle and poor patient compliance.

[0003] Meanwhile, electromagnetic fields and ultrasound have been widely studied and applied in the medical field. Electromagnetic fields can regulate the physiological functions of cells, promote the proliferation and differentiation of osteoblasts, and improve bone metabolism. Ultrasound has mechanical, thermal, and cavitation effects, which can enhance the transdermal absorption of drugs, promote local blood circulation, and accelerate tissue repair. However, existing treatment devices often use electromagnetic fields, ultrasound, and drug therapy separately, which cannot fully utilize their synergistic effects, and the treatment effect needs to be further improved. Therefore, this invention provides a device that can combine electromagnetic fields, ultrasound, and denosumab to achieve efficient and precise treatment of osteoporosis. Summary of the Invention

[0004] The purpose of this invention is to provide a device for treating osteoporosis by combining electromagnetic field and ultrasound with denosumab. By combining electromagnetic field and ultrasound technology with denosumab drug therapy, the absorption efficiency and therapeutic effect of the drug are improved, thereby achieving precise and efficient treatment of osteoporosis.

[0005] To achieve the above objectives, the present invention provides the following technical solution:

[0006] A device for treating osteoporosis using a combination of electromagnetic field and ultrasound with denosumab includes a base plate, a support mattress plate fixedly mounted on the upper surface of the base plate, a limiting groove formed in the base plate, a transmission component movably disposed within the limiting groove, a drug delivery module, an electromagnetic field generating module, and an ultrasound generating module fixedly mounted on the surface of the transmission component, the drug delivery module, the electromagnetic field generating module, and the ultrasound generating module being electrically connected to an external control module, and the external control module having a built-in display and interaction module;

[0007] The external control module is used to receive treatment parameters and instructions input by the display and interaction module, control the drug delivery module, electromagnetic field generation module and ultrasound generation module to work together, and monitor the working status and treatment parameters of each module in real time.

[0008] The display interaction module includes a touch screen and operation buttons. The touch screen is used to display treatment parameters, treatment progress, and the working status of each module, and supports users to input treatment parameters and commands through touch operation. The operation buttons are used to provide quick operation methods.

[0009] Preferably, the electromagnetic field generating module includes multiple electromagnetic field generators and magnetic conductive sheets. The multiple electromagnetic field generators are evenly distributed inside its main body shell to generate electromagnetic fields of different frequencies and intensities.

[0010] Preferably, the ultrasonic generating module includes an ultrasonic transducer array, which consists of multiple ultrasonic transducers distributed inside its main body shell, for generating ultrasonic waves of different frequencies and intensities.

[0011] Preferably, the electromagnetic field generator can adjust the frequency, intensity, and waveform of the generated electromagnetic field; the magnetic conductive sheet is made of ferrite material with a thickness of 2 mm; and the ultrasonic transducer array can adjust the frequency, intensity, and emission direction of the generated ultrasonic waves.

[0012] Preferably, the transmission assembly includes a drive cylinder, which is fixedly installed on the inner wall of the limiting groove, and the output shaft of the drive cylinder is fixedly connected to the slider. The slider slides in the limiting groove, and an L-shaped adjustment plate is fixedly installed on the upper surface of the slider.

[0013] A motor A is fixedly installed above the L-shaped adjustment plate. A groove is opened on the surface of the L-shaped adjustment plate, and a threaded rod is rotatably installed in the groove. The upper end of the threaded rod rotatably passes through the L-shaped adjustment plate and is fixedly connected to the output shaft of the motor A. The threaded rod is threadedly sleeved with the rear protrusion of the transmission plate, and the back protrusion of the transmission plate slides and splices in the groove.

[0014] Preferably, the drug delivery module includes an arc-shaped outer frame, a sliding groove is provided inside the arc-shaped outer frame, an arc-shaped sliding plate is slidably disposed in the sliding groove, and a fixing rod is fixedly installed on the inner wall of the sliding groove;

[0015] A transmission rack is fixedly installed on the surface of the arc-shaped sliding plate, an atomizing nozzle mechanism is fixedly installed on the back of the arc-shaped sliding plate, and a drive assembly is fixedly installed on the surface of the arc-shaped outer frame. The drive assembly drives the arc-shaped sliding plate to slide in the sliding groove.

[0016] Preferably, the drive assembly includes two sets of mounting seats, which are respectively fixedly installed at both ends of the arc-shaped outer frame, and a rotating rod is fixedly installed between the mounting seats. A transmission gear B is fixedly installed on the surface of the rotating rod.

[0017] The outer shell is fixedly mounted on the surface of the arc-shaped outer shell, and the motor B is fixedly mounted on the surface of the outer shell. The output shaft of the motor B is fixedly connected to the transmission gear A. The transmission gear A rotates through the outer shell and meshes with the transmission gear B.

[0018] Preferably, a medicine storage tank is provided on one inner wall of the outer shell, and a water pump is fixedly installed on the surface of the outer shell. The input end of the water pump is connected to the medicine storage tank, and the output end of the water pump is connected to the atomizing nozzle mechanism through a conduit.

[0019] The technical effects and advantages provided by the present invention in the above technical solution are as follows:

[0020] This invention achieves a synergistic effect of multiple treatment methods by combining electromagnetic fields, ultrasound, and drug-assisted therapy. Electromagnetic fields can regulate the physiological functions of bone cells, promote their proliferation and differentiation, and improve bone metabolism. Ultrasound utilizes mechanical, thermal, and cavitation effects to enhance the transdermal absorption of the drug solution, promote local blood circulation, and accelerate the distribution and action of the drug in bone tissue. The drug solution binds to the receptor-activated protein ligand (RANKL) of nuclear factor κB, inhibiting the generation, function, and survival of osteoclasts and reducing bone resorption. The synergistic effect of these three methods improves the treatment efficacy of osteoporosis, increasing bone density more quickly and effectively and shortening the treatment cycle compared to single treatment methods.

[0021] This invention, through the design of a base plate, a supporting mattress plate, and a transmission component, allows for the adjustment of the position and angle of the drug delivery module, electromagnetic field generation module, and ultrasonic wave generation module according to the different treatment sites of the patient. This is achieved by using components such as a drive cylinder and motor A, ensuring precise alignment with the anatomical structures of different skeletal locations such as the lumbar spine and hip joint. Simultaneously, an external control module can precisely control the generation of electromagnetic fields and ultrasonic waves of different frequencies and intensities, as well as the delivery dosage of denosumab solution, based on personalized treatment parameters input from the display and interaction module. This enables precise and personalized treatment for different patients and conditions, improving the accuracy and effectiveness of the treatment.

[0022] In this invention, the design of the arc-shaped outer frame, arc-shaped sliding plate, and drive assembly in the drug delivery module allows the atomizing nozzle mechanism to move flexibly within a certain range, expanding the spray coverage area of ​​the liquid medicine and ensuring that the liquid medicine can act evenly on the treatment site. In addition, the slider, L-shaped adjusting plate, threaded rod, and other structures in the transmission assembly, together with the drive cylinder and motor A, can adjust the position of the treatment device, which not only adapts to the physical characteristics of different patients, but also allows for flexible adjustment according to actual needs during the treatment process, further improving the targeting and effectiveness of the treatment. Attached Figure Description

[0023] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this invention. For those skilled in the art, other drawings can be obtained based on these drawings.

[0024] Figure 1 This is a schematic diagram of the structure of a device for treating osteoporosis using a combination of electromagnetic field, ultrasound, and denosumab, as proposed in this invention.

[0025] Figure 2 for Figure 1 A schematic diagram of the structure inside circle A;

[0026] Figure 3 for Figure 1 A schematic diagram of the drug delivery module structure;

[0027] Figure 4 for Figure 3 A schematic diagram of the disassembled structure;

[0028] Figure 5 for Figure 4 System flowchart of a device for treating osteoporosis using electromagnetic fields, ultrasound, and denosumab.

[0029] Explanation of reference numerals in the attached figures:

[0030] 1. Base plate; 2. Support mattress plate; 3. Transmission assembly; 4. Ultrasonic generating module; 5. Electromagnetic field generating module; 6. Drug delivery module; 101. Limiting groove; 301. Drive cylinder; 302. L-shaped adjusting plate; 303. Slider; 304. Motor A; 305. Threaded rod; 306. Transmission plate; 601. Arc-shaped outer frame; 602. Fixing rod; 603. Sliding groove; 604. Arc-shaped sliding plate; 605. Transmission rack; 606. Outer shell; 607. Water pump; 608. Motor B; 609. Transmission gear A; 610. Mounting base; 611. Rotating rod; 612. Transmission gear B. Detailed Implementation

[0031] To enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings.

[0032] This invention discloses a device for treating osteoporosis using electromagnetic field, ultrasound, and denosumab combined with other methods.

[0033] Reference Figure 1-5 A device for treating osteoporosis using a combination of electromagnetic field and ultrasound with desulamb, comprising a base plate 1, a support mattress plate 2 fixedly mounted on the upper surface of the base plate 1, a limiting groove 101 formed in the base plate 1, a transmission component 3 movably disposed in the limiting groove 101, a drug delivery module 6, an electromagnetic field generating module 5, and an ultrasound generating module 4 fixedly mounted on the surface of the transmission component 3, the drug delivery module 6, the electromagnetic field generating module 5, and the ultrasound generating module 4 being electrically connected to an external control module, and the external control module having a display and interaction module.

[0034] The external control module is used to receive treatment parameters and instructions input by the display and interaction module, control the coordinated operation of the drug delivery module 6, the electromagnetic field generation module 5 and the ultrasound generation module 4, and monitor the working status and treatment parameters of each module in real time.

[0035] The display and interaction module includes a touch screen and operation buttons. The touch screen is used to display treatment parameters, treatment progress, and the working status of each module, and supports users to input treatment parameters and commands through touch operation. The operation buttons are used to provide quick operation methods.

[0036] The electromagnetic field generating module 5 includes multiple electromagnetic field generators and magnetic conductive sheets. The multiple electromagnetic field generators are evenly distributed inside its main body shell to generate electromagnetic fields of different frequencies and intensities.

[0037] The ultrasonic generating module 4 includes an ultrasonic transducer array, which consists of multiple ultrasonic transducers distributed inside its main body shell, and is used to generate ultrasonic waves of different frequencies and intensities.

[0038] The electromagnetic field generator can adjust the frequency, intensity, and waveform of the generated electromagnetic field; the magnetic conductive sheet is made of ferrite material with a thickness of 2mm; the ultrasonic transducer array can adjust the frequency, intensity, and emission direction of the generated ultrasonic waves.

[0039] The transmission assembly 3 includes a drive cylinder 301, which is fixedly installed on the inner wall of the limiting groove 101. The output shaft of the drive cylinder 301 is fixedly connected to the slider 303. The slider 303 slides in the limiting groove 101. An L-shaped adjusting plate 302 is fixedly installed on the upper surface of the slider 303.

[0040] A motor A304 is fixedly installed on the top of the L-shaped adjusting plate 302. A groove is opened on the surface of the L-shaped adjusting plate 302, and a threaded rod 305 is rotatably installed in the groove. The upper end of the threaded rod 305 rotatably passes through the L-shaped adjusting plate 302 and is fixedly connected to the output shaft of the motor A304. The threaded rod 305 is threadedly sleeved with the rear protrusion of the transmission plate 306, and the back protrusion of the transmission plate 306 slides and splices in the groove.

[0041] The drug delivery module 6 includes an arc-shaped outer frame 601, a sliding groove 603 is provided inside the arc-shaped outer frame 601, an arc-shaped sliding plate 604 is slidably disposed inside the sliding groove 603, and a fixing rod 602 is fixedly installed on the inner wall of the sliding groove 603.

[0042] A transmission rack 605 is fixedly installed on the surface of the arc-shaped sliding plate 604, and an atomizing nozzle mechanism is fixedly installed on the back of the arc-shaped sliding plate 604. A drive assembly is fixedly installed on the surface of the arc-shaped outer frame 601, and the drive assembly drives the arc-shaped sliding plate 604 to slide in the sliding groove 603.

[0043] The drive assembly includes two sets of mounting bases 610, which are fixedly installed at both ends of the arc-shaped outer frame 601. A rotating rod 611 is fixedly installed between the mounting bases 610, and a transmission gear B612 is fixedly installed on the surface of the rotating rod 611.

[0044] A housing 606 is fixedly mounted on the surface of an arc-shaped housing. A motor B608 is fixedly mounted on the surface of the housing 606. The output shaft of the motor B608 is fixedly connected to a transmission gear A609. The transmission gear A609 rotates through the housing 606 and meshes with the transmission gear B612.

[0045] A medicine storage tank is provided on one inner wall of the outer shell 606. A water pump 607 is fixedly installed on the surface of the outer shell 606. The input end of the water pump 607 is connected to the medicine storage tank, and the output end of the water pump 607 is connected to the atomizing nozzle mechanism through a conduit.

[0046] It is worth noting that denosumab is administered once every six months, and the external control module can be set to remind you of the next injection time.

[0047] In this invention, when used, it is for the treatment of lumbar osteoporosis:

[0048] The patient lies on the support mattress board 2, adjusts his / her position so that the lumbar spine is directly facing the drug delivery module 6, the electromagnetic field generation module 5 and the ultrasound generation module 4;

[0049] Treatment parameters are set via the touchscreen display of the interactive module: drug delivery dose is 2ml, electromagnetic field frequency is 50Hz, intensity is 5mT, and ultrasound frequency is 1MHz with intensity of 1.5W / cm². 2 The treatment time is set to 30 minutes;

[0050] After receiving the treatment parameters, the external control module starts the drive cylinder 301. The output shaft of the drive cylinder 301 pushes the slider 303 to slide in the limit groove 101, which drives the L-shaped adjustment plate 302, the transmission plate 306 and the modules installed on the transmission plate 306 to move, so that each module is accurately positioned to the patient's lumbar spine treatment site. Then, the motor A304 starts and drives the transmission plate 306 up and down through the threaded rod 305 to further adjust to the appropriate position.

[0051] It is worth noting that the transmission component 3 is not limited to the above structure. It can be designed with a structure with directional wheels, which facilitates flexible movement and allows the drug delivery module 6, electromagnetic field generation module 5, and ultrasonic wave generation module 4 to be removed and used separately, making it convenient for home use.

[0052] The external control module starts motor B608, which drives transmission gear A609 to rotate. Transmission gear A609 meshes with transmission gear B612, causing rotating rod 611 to rotate, which in turn drives transmission gear B612 to rotate. Transmission gear B612 meshes with transmission rack 605, pushing arc-shaped sliding plate 604 to slide in sliding groove 603, causing the atomizing nozzle mechanism to move within a certain range. At the same time, water pump 607 is started, delivering denosumab solution from the drug storage tank to the atomizing nozzle mechanism through a conduit. The atomizing nozzle mechanism sprays the solution evenly onto the patient's lumbar spine skin surface.

[0053] The external control module activates the electromagnetic field generating module 5, which generates an electromagnetic field with a frequency of 50Hz and an intensity of 5mT. Guided by a magnetic sheet, the electromagnetic field acts on the patient's lumbar vertebral bone tissue to regulate the physiological function of bone cells.

[0054] The control module activates the ultrasonic generator module 4, and the ultrasonic transducer array generates an ultrasonic wave with a frequency of 1MHz and an intensity of 1.5W / cm². 2 The ultrasound waves utilize the mechanical, thermal, and cavitation effects of ultrasound to enhance the transdermal absorption of denosumab solution and promote local blood circulation.

[0055] During treatment, the control module monitors the working status and treatment parameters of each module in real time, such as the remaining amount of medicine, electromagnetic field strength, and ultrasonic frequency. If any abnormality is detected, such as blockage of medicine delivery or electromagnetic field or ultrasonic parameters exceeding the safe range, the control module will immediately make automatic adjustments or issue an alarm.

[0056] After the treatment time is over, the external control module stops all modules from working, and the interactive module displays a message indicating that the treatment is complete.

[0057] It should be understood that the embodiments of this application are not limited to the precise structures described above and shown in the accompanying drawings, and various modifications and changes can be made without departing from their scope. The scope of the embodiments of this application is limited only by the appended claims.

[0058] The above-described embodiments are merely illustrative of several implementation methods of the embodiments of this application, and their descriptions are relatively specific and detailed, but they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make several modifications and improvements without departing from the concept of the embodiments of this application, and these all fall within the protection scope of the embodiments of this application.

Claims

1. A device for treating osteoporosis using electromagnetic field, ultrasound, and denosumab, comprising a base plate (1), wherein a supporting mattress plate (2) is fixedly mounted on the upper surface of the base plate (1), characterized in that, A limiting groove (101) is provided in the base plate (1), and a transmission component (3) is movably arranged in the limiting groove (101). A drug delivery module (6), an electromagnetic field generating module (5), and an ultrasonic wave generating module (4) are fixed on the surface of the transmission component (3). The drug delivery module (6), the electromagnetic field generating module (5), and the ultrasonic wave generating module (4) are electrically connected to an external control module, and the external control module is equipped with a display interaction module. The external control module is used to receive treatment parameters and instructions input by the display interaction module, control the drug delivery module (6), electromagnetic field generation module (5) and ultrasound generation module (4) to work together, and monitor the working status and treatment parameters of each module in real time. The display interaction module includes a touch screen and operation buttons. The touch screen is used to display treatment parameters, treatment progress, and the working status of each module, and supports users to input treatment parameters and commands through touch operation. The operation buttons are used to provide quick operation methods.

2. The device for treating osteoporosis using electromagnetic field, ultrasound, and denosumab combined according to claim 1, characterized in that, The electromagnetic field generating module (5) includes multiple electromagnetic field generators and magnetic conductive sheets. The multiple electromagnetic field generators are evenly distributed inside its main body shell to generate electromagnetic fields of different frequencies and intensities.

3. The device for treating osteoporosis using electromagnetic field, ultrasound, and denosumab combined according to claim 1, characterized in that, The ultrasonic generating module (4) includes an ultrasonic transducer array, which consists of multiple ultrasonic transducers distributed inside its main body shell, for generating ultrasonic waves of different frequencies and intensities.

4. The device for treating osteoporosis using electromagnetic field, ultrasound, and denosumab combined according to claim 1, characterized in that, The electromagnetic field generator can adjust the frequency, intensity, and waveform of the generated electromagnetic field; the magnetic conductive sheet is made of ferrite material with a thickness of 2mm; the ultrasonic transducer array can adjust the frequency, intensity, and emission direction of the generated ultrasonic waves.

5. The device for treating osteoporosis using electromagnetic field, ultrasound, and denosumab combined according to claim 1, characterized in that, The transmission assembly (3) includes a drive cylinder (301), which is fixedly installed on the inner wall of the limiting groove (101), and the output shaft of the drive cylinder (301) is fixedly connected to the slider (303). The slider (303) slides in the limiting groove (101), and an L-shaped adjusting plate (302) is fixedly installed on the upper surface of the slider (303). A motor A (304) is fixedly installed above the L-shaped adjusting plate (302). A groove is opened on the surface of the L-shaped adjusting plate (302), and a threaded rod (305) is rotatably installed in the groove. The upper end of the threaded rod (305) rotatably passes through the L-shaped adjusting plate (302) and is fixedly connected to the output shaft of the motor A (304). The threaded rod (305) is threadedly sleeved with the rear protrusion of the transmission plate (306), and the back protrusion of the transmission plate (306) slides and splices in the groove.

6. The device for treating osteoporosis using electromagnetic field, ultrasound, and denosumab combined according to claim 1, characterized in that, The drug delivery module (6) includes an arc-shaped outer frame (601), a sliding groove (603) is provided in the arc-shaped outer frame (601), an arc-shaped sliding plate (604) is slidably arranged in the sliding groove (603), and a fixing rod (602) is fixedly installed on the inner wall of the sliding groove (603). A transmission rack (605) is fixedly installed on the surface of the arc-shaped sliding plate (604), and an atomizing nozzle mechanism is fixedly installed on the back of the arc-shaped sliding plate (604). A driving component is fixedly installed on the surface of the arc-shaped outer frame (1), and the driving component drives the arc-shaped sliding plate (604) to slide in the sliding groove (603).

7. The device for treating osteoporosis using electromagnetic field, ultrasound combined with denosumab according to claim 6, characterized in that, The drive assembly includes two sets of mounting bases (610), which are fixedly installed at both ends of the arc-shaped outer frame (1). A rotating rod (611) is fixedly installed between the mounting bases (610), and a transmission gear B (612) is fixedly installed on the surface of the rotating rod (611). The arc-shaped outer shell (601) is fixedly mounted with an outer shell body (606), and a motor B (608) is fixedly mounted on the outer shell body (606). The output shaft of the motor B (608) is fixedly connected to the transmission gear A (609). The transmission gear A (609) rotates through the outer shell body (606) and meshes with the transmission gear B (612).

8. The device for treating osteoporosis using electromagnetic field, ultrasound, and denosumab combined according to claim 7, characterized in that, A medicine storage tank is provided on one inner wall of the outer shell (606), and a water pump (607) is fixedly installed on the surface of the outer shell (606). The input end of the water pump (607) is connected to the medicine storage tank, and the output end of the water pump (607) is connected to the atomizing nozzle mechanism through a conduit.

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