Antistatic medical gauze and preparation method thereof

Abstract

The application discloses an antistatic medical gauze and a preparation method thereof, and relates to the technical field of medical gauze.The antistatic medical gauze comprises the following raw materials in parts by mass: cotton fiber 60-80 parts, an antistatic agent 1-5 parts, a water-soluble polymer 5-15 parts, and an antibacterial agent 0.5-1 part.Compared with the antistatic effect being short-term and being easily affected by environmental factors in the prior art, the application introduces a specific small-molecule antistatic agent (such as a compound shown in formula 1), combines the moisture absorption and conductivity mechanism, ionization and surface energy adjustment, and realizes long-term and stable charge neutralization capability.This trend is embodied in that static electricity is dissipated faster and the effect is long-lasting, safety hazards and dust adsorption problems caused by charge accumulation are effectively avoided, and the short-term antistatic effect of the prior art is overcome.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical gauze, and particularly relates to an antistatic medical gauze and a preparation method thereof. BACKGROUND

[0002] In the modern medical environment, medical gauze, as a common medical supply, is widely used in wound care, surgical dressing and various medical operations. However, there is a significant problem in the practical application of traditional medical gauze - static accumulation. Static electricity not only makes the gauze adsorb dust and microorganisms during use, reducing its cleaning effect, but also may cause discomfort to the human body, and even cause safety hazards in some specific cases.

[0003] This static phenomenon is particularly serious in dry environments, especially in places such as operating rooms and intensive care units of hospitals, which have very high requirements for the environment. Static electricity may interfere with the normal operation of medical equipment, and even pose a potential threat to patients and medical staff in extreme cases. In addition, traditional medical gauze also has deficiencies in antibacterial performance and comfort, which cannot meet the urgent demand for multifunctional materials in modern medicine.

[0004] At present, common methods to solve the problem of static electricity include adding antistatic agents or using surface treatment technology. However, these methods often have the disadvantages of short-term effect, complex processing conditions or high cost, which are difficult to be widely used in the field of medical gauze. Therefore, developing a new type of medical gauze with antistatic, antibacterial and comfortable properties is of great significance to improve medical quality and patient experience. SUMMARY

[0005] The present application aims to provide a multifunctional medical gauze with antistatic, antibacterial and comfortable properties, which significantly reduces the harm of static electricity, improves the antibacterial performance, and enhances the use experience by introducing small molecule antistatic agents and high efficiency antibacterial agents, and optimizing the length of cotton fibers and the weaving process.

[0006] To achieve the above-mentioned purpose, the technical solution adopted by the present application is: a small molecule antistatic agent, the antistatic agent is a compound represented by formula 1:

[0007] Formula 1: ;

[0008] R1 in formula 1 is selected from: cyano, alkyl with carbon atom number 1-5;

[0009] or R1 is selected from: alkyl with carbon atom number 1-5 substituted by cyano, hydroxyl.

[0010] Further, the alkyl with carbon atom number 1-5 is selected from: methyl, ethyl, propyl.

[0011] Further, the antistatic agent is any one of the compounds shown in the following structure:

[0012] ;

[0013] .

[0014] An antistatic medical gauze comprising an antistatic agent therein.

[0015] Further, the antistatic medical gauze comprises the following raw materials in mass parts: cotton fiber 60-80 parts, antistatic agent 1-5 parts, water-soluble polymer 5-15 parts, antibacterial agent 0.5-1 part;

[0016] The antistatic agent is a compound of Formula 1.

[0017] Further, the cotton fiber is combed cotton, and the fiber length is 25-35 mm.

[0018] Further, the water-soluble polymer is selected from polyvinyl alcohol or sodium carboxymethyl cellulose.

[0019] Further, the antibacterial agent is selected from cetyltrimethylammonium bromide or benzalkonium chloride.

[0020] A preparation method of an antistatic medical gauze, comprising the following steps:

[0021] (1) mixing the antistatic agent, water-soluble polymer and antibacterial agent in water to form solution A;

[0022] (2) immersing the cotton fiber in the solution A to ensure sufficient penetration to obtain soaked cotton fiber;

[0023] (3) drying the soaked cotton fiber at 40-65°C to obtain modified cotton fiber;

[0024] (4) weaving the modified cotton fiber to make medical gauze.

[0025] Further, the weaving in step (4) uses a circular knitting machine or a flat knitting machine to weave the medical gauze into a plain weave structure or a mesh structure, wherein the mesh density is 10-20 meshes per square centimeter.

[0026] The antistatic mechanism of the antistatic agent described in the present application mainly includes: moisture absorption and conductivity mechanism, ionization and surface energy adjustment. The triazine group in the molecular structure as the molecular core is an electron-rich heterocyclic structure with strong polarity and hydrogen bond formation ability. It can effectively adsorb moisture in the environment and form a thin water film. This layer of water film as a conductor can quickly dissipate static charge (the main cause of static accumulation is the retention of electric charge caused by the insulation of the material). At the same time, the triazine group provides stability through its ring structure, ensuring long-lasting antistatic effect, overcoming the shortcoming of traditional antistatic agents "short-term effect". The hydroxyl (-OH) and carboxylic acid group (-COOH) are strong hydrophilic groups that can ionize in aqueous solution. The hydroxyl group enhances water adsorption through hydrogen bonding, while the carboxylic acid group ionizes to form carboxylate ions and protons, forming ion channels. These ions migrate on the surface or inside the material, significantly improving the electrical conductivity (reducing electrical resistance), thereby neutralizing static charge. The alkane chain in the structure gives the antistatic agent a certain hydrophobicity, allowing it to uniformly disperse on the surface of the cotton fibers. At the same time, the alkane chain is compatible with the natural hydrophobic region of the cotton fibers, reducing the interfacial energy and promoting uniform coating of the antistatic agent on the fibers. This coating film forms a "conductive network structure", not only neutralizing static electricity, but also enhancing the mechanical strength and wear resistance of the gauze.

[0027] The small molecule antistatic agent as the core component, the antistatic agent is responsible for directly solving the problem of static accumulation, its structure (as shown in formula 1) through the mechanism of moisture absorption and conductivity, ionization and surface energy adjustment, long-acting neutralization of static charge, avoiding charge retention. Cotton fibers as the main body of gauze, provide the basis for comfort and breathability. Combed cotton fiber length is moderate (25-35mm), ensuring softness, breathability of gauze, reducing patient discomfort. In the preparation process, the cotton fibers are immersed in the antistatic agent solution, and the natural hydrophobic region of the fiber surface is compatible with the alkane chain of the antistatic agent, promoting uniform coating. This enhances the formation of a conductive network structure, while not compromising the natural comfort of the fibers. The physical structure of the cotton fibers (such as fiber length) provides a stable carrier for the antistatic agent and the antibacterial agent, ensuring the synergistic effect of the components. The water-soluble polymer mainly serves as a carrier and adhesive. The water-soluble polymer is mixed with the antistatic agent and the antibacterial agent in water to form solution A, and its water-soluble nature helps the antistatic agent and the antibacterial agent disperse uniformly, avoiding agglomeration, ensuring that each component penetrates uniformly on the surface of the fibers. The polymer forms a thin film during the drying process, firmly attaching the antistatic agent and the antibacterial agent to the cotton fibers, preventing the components from falling off, which not only stabilizes the antistatic effect, but also indirectly supports the sustained release of the antibacterial agent. By optimizing the solution viscosity, the water-soluble polymer ensures sufficient penetration during the immersion process, maximizing the contact area of each component and improving overall performance. The antibacterial agent can effectively kill or inhibit microorganisms, preventing wound infection. The antistatic agent reduces static adsorption of dust and microorganisms, indirectly reducing the risk of pollution; at the same time, the antibacterial agent is more likely to release active ions in an ionized environment, enhancing the antibacterial efficiency.

[0028] Compared with the prior art, the beneficial effects of the present application are:

[0029] 1. Long-lasting antistatic performance is significantly improved: Compared with the short-term and easily affected by environmental factors in traditional technology, the present application realizes long-term stable charge neutralization ability by introducing specific small molecule antistatic agent (such as compound shown in formula 1), combined with hygroscopic conductive mechanism, ionization and surface energy adjustment. This trend reflects that the static electricity is dissipated faster and the effect is lasting, effectively avoiding the safety hazards and dust adsorption problems caused by charge accumulation, overcoming the shortcomings of the existing technology that the antistatic agent effect is not lasting.

[0030] 2. The antibacterial stability is greatly enhanced: the existing medical gauze often faces the problem of decay of antibacterial performance over time, the present application integrates antistatic agent and high-efficiency antibacterial agent (such as cetyl trimethyl ammonium bromide) in gauze, forming a synergistic mechanism to ensure the long-term stability of antibacterial effect. The trend is that the bacteriostatic rate only decreases slightly over time, maintaining a high bacteriostatic state, significantly reducing the risk of bacterial growth and infection, and improving the health and safety in the medical environment.

[0031] 3. The overall performance and comfort are optimized: compared with the pain points of poor comfort and complex processing of gauze in the prior art, the present application realizes the synergistic improvement of mechanical strength, wear resistance and air permeability of gauze by optimizing the length of cotton fiber, adding water-soluble polymer and weaving process (such as round knitting machine control mesh density). This trend reflects the improvement of overall use experience of gauze, including reducing patient discomfort, enhancing durability, and simplifying the preparation process, so as to meet the higher demand of modern medicine for multifunctional materials. BRIEF DESCRIPTION OF DRAWINGS

[0032] Figure 1 NMR chart of antistatic agent 1 described in the present application. DETAILED DESCRIPTION

[0033] The technical solutions of the present application will be described clearly and completely in combination with the drawings in the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor belong to the scope of protection of the present application.

[0034] Preparation example 1

[0035] Preparation of antistatic agent 1:

[0036] ;

[0037] First step: under nitrogen protection, 20 g of raw material 1 and 20.11 g of raw material 2 were dissolved in 250 ml of toluene solution, 20.31 g of sodium tert-butoxide, 2.90 g of tris (dibenzylideneacetone) dipalladium, 1.07 g of tri-tert-butyl phosphine were added, stirred uniformly, heated to 120℃, and refluxed for 12 h; after the reaction was completed, the temperature was slightly lowered, diatomite was used for filtration to remove salt and catalyst, the filtrate was cooled to room temperature, washed with water three times, the organic phase was retained, then the water phase was extracted with ethyl acetate; after the organic phases were combined, the organic phase was spin-dried, column chromatography (silica gel column chromatography, using a mixed solution of petroleum ether and ethyl acetate as eluent) was performed, spin-dried, and 14.70 g of intermediate 1 was obtained.

[0038] ;

[0039] Second step: under nitrogen protection, 14.70 g of intermediate 1 and 15.24 g of raw material 3 were dissolved in 200 ml of toluene solution, 9.07 g of sodium tert-butoxide, 1.30 g of tris (dibenzylideneacetone) dipalladium, 0.5 g of tri-tert-butyl phosphine were added, stirred uniformly, heated to 120℃, and refluxed for 12 h; after the reaction was completed, the temperature was slightly lowered, diatomite was used for filtration to remove salt and catalyst, the filtrate was cooled to room temperature, washed with water three times, the organic phase was retained, then the water phase was extracted with ethyl acetate; after the organic phases were combined, the organic phase was spin-dried, column chromatography (silica gel column chromatography, using a mixed solution of petroleum ether and ethyl acetate as eluent) was performed, spin-dried, and 18.67 g of antistatic agent 1 was obtained.

[0040] Product structure identification:

[0041] Mass spectrum M / Z MS+1 of intermediate 1: 312;

[0042] Mass spectrum M / Z MS+1 of antistatic agent 1: 500;

[0043] Antistatic agent 1 1 H NMR (Chloroform-d), Figure 1 : δ 5.04 (s, 1H), 4.16-3.97 (m, 3H), 3.91-3.75 (m, 3H), 3.61-3.51 (m, 4H), 3.38 (s, 3H), 3.12 (d, 2H), 2.71 (t, 2H), 2.34 (s, 3H), 2.07-1.94 (m, 1H), 1.87-1.73 (m, 1H), 1.71-1.51 (m, 5H), 1.49-1.37 (m, 5H), 1.37-1.25 (m, 6H), 0.96-0.87 (m, 6H).

[0044] Preparation Example 2-Preparation Example 6

[0045] Preparation Example 2-Preparation Example 6, the antistatic agents 2-5 were synthesized in sequence, referring to the preparation method of Preparation Example 1, replacing the raw material 2 therein, and the rest being the same as Preparation Example 1. See Table 1 for details.

[0046] Table 1.

[0047] Structure of raw material 2 Structure of antistatic agents 2-5 Product structure identification Mass Spec M / Z MS+1 Preparation Example 2 514 Preparation Example 3 528 Preparation Example 4 511 Preparation Example 5 525 Preparation Example 6 530

[0048] Example 1

[0049] Preparation of an antistatic medical gauze:

[0050] 1. Raw material composition:

[0051] Cotton fiber: 70 parts (selecting combed cotton, fiber length 30 mm, purchased from Zhejiang Xinmian Textile Co., Ltd.); Antistatic agent: 3 parts (using the antistatic agent 1 obtained in Preparation Example 1);

[0052] Soluble polymer: 10 parts (selecting polyvinyl alcohol, purchased from Shanghai Aladdin Biochem Technology Co., Ltd.);

[0053] Antibacterial agent: 0.8 parts (selecting cetyltrimethylammonium bromide, purchased from Shanghai Aladdin Biochem Technology Co., Ltd.);

[0054] Water: as a solvent, the amount is 200 parts (deionized water).

[0055] 2. Preparation method:

[0056] (1) Mix 3 parts of antistatic agent 1, 10 parts of polyvinyl alcohol, and 0.8 parts of cetyltrimethylammonium bromide in 200 parts of water. Stir at 200 rpm for 30 minutes at room temperature (25°C) until a uniform transparent solution A is formed;

[0057] (2) Dip 70 parts of combed cotton fiber in solution A. The dipping process is carried out at 40°C for 60 minutes, with intermittent stirring (stirring every 10 minutes, 5 minutes each time), after which the soaked cotton fiber is taken out and the excess solution is drained, obtaining uniformly modified soaked cotton fiber;

[0058] (3) Place the soaked cotton fiber in a drying oven and dry at 50°C for 120 minutes. After drying, the moisture content of the fiber is less than 5%, obtaining dried modified cotton fiber;

[0059] (4) Use a circular knitting machine to knit the modified cotton fiber into a medical gauze with a plain structure, and set the knitting parameters as follows: mesh density 15 meshes per square centimeter. After knitting, the gauze is cut and the edges are treated to obtain the finished antistatic medical gauze.

[0060] Examples 2-6

[0061] A preparation of an antistatic medical gauze, according to the preparation method of Example 1, the antistatic agent therein is replaced by antistatic agent 2-antistatic agent 6 in turn, and the rest is the same as Example 1.

[0062] Comparative Example 1

[0063] A preparation of an antistatic medical gauze, according to the preparation method of Example 1, the antistatic agent therein is replaced by antistatic agent SN (CAS: 86443-82-5, ), and the rest is the same as Example 1.

[0064] Comparative Example 2

[0065] A preparation of an antistatic medical gauze, according to the preparation method of Example 1, the antistatic agent therein is replaced by antistatic agent TM (purchased from Changzhou Deren Yuan New Material Technology Co., Ltd.), and the rest is the same as Example 1.

[0066] Comparative Example 3

[0067] A preparation of an antistatic medical gauze, according to the preparation method of Example 1, the antistatic agent therein is not added, and the rest is the same as Example 1.

[0068] Comparative Example 4

[0069] A preparation of an antistatic medical gauze, according to the preparation method of Example 1, the antibacterial agent therein is not added, and the rest is the same as Example 1.

[0070] Performance test:

[0071] (1) Antimicrobial property and antimicrobial stability: according to GB / T 20944.3-2008 Evaluation of antibacterial property of textiles Part 3: shake flask method, after 28 days and 56 days, the antimicrobial property is tested again according to the above method, the test strain is Staphylococcus aureus, and the data is shown in Table 2.

[0072] Antistatic property evaluation: according to the national standard GB / T 12703.1-2008 Evaluation of static property of textiles Part 1: static voltage and half-life, the antistatic medical gauze prepared in the examples is tested, the test condition is temperature 20℃, relative humidity 35%. After the gauze is placed for 56 days, it is measured again, and the evaluation is carried out by half-life (s) of static voltage, short half-life indicates good antistatic property (because static charge dissipates quickly), and the data is shown in Table 2.

[0073] Table 2.

[0074] Bacteriostatic rate (%) at 0 days Bacteriostatic rate (%) at 28 days Bacteriostatic rate (%) at 56 days Half-life (s) Half-life (s) after 56 days Example 1 99.9 99.8 99.6 0.3 0.3 Example 2 99.9 99.9 99.7 0.2 0.2 Example 3 99.9 99.9 99.7 0.2 0.3 Example 4 99.9 99.9 99.6 0.4 0.4 Example 5 99.9 99.7 99.4 0.3 0.4 Example 6 99.9 99.9 99.7 0.1 0.2 Comparative Example 1 93.6 93.0 92.6 1.1 1.4 Comparative Example 2 94.1 93.8 93.0 1.5 2.2 Comparative Example 3 90.8 90.0 89.2 4.6 5.9 Comparative Example 4 50.3 45.6 41.8 1.5 1.6

[0075] All example groups (using the antistatic agent of the application) exhibit highly stable bacteriostatic effects in terms of antibacterial performance, with only slight decline in bacteriostatic rate over time, maintaining near-perfect levels, while the comparative groups have lower initial bacteriostatic rates and continue to decay over time, showing obvious performance degradation. In terms of antistatic performance, the half-life is a key indicator (short half-life indicates fast dissipation of static charge, strong antistatic properties), and the example groups generally have very short half-lives, reflecting excellent antistatic properties; in contrast, the half-lives of the comparative groups are significantly prolonged, indicating poor antistatic effects. This is directly related to the effectiveness of the antistatic agent: the antistatic agent in the example groups effectively neutralizes the charge through the hygroscopic conductive mechanism and ionization, thereby shortening the half-life; while the comparative groups are due to improper or missing selection of the antistatic agent, leading to the accumulation of charge, prolonging the half-life, further affecting the overall safety and practicality of the gauze. Overall, the antistatic agent design of the application significantly improves the stability of the antistatic performance while maintaining long-acting antibacterial properties.

[0076] Although embodiments of the application have been shown and described, it is to be understood that the application is not limited to the details of the above-described embodiments, and that various changes, modifications, substitutions and alterations can be made thereto without departing from the spirit and scope of the application as defined in the appended claims and their equivalents.

Claims

1. A small molecule antistatic agent, characterized in that, The antistatic agent is a compound shown in formula 1: Formula 1: ; R1 in formula 1 is selected from: cyano, alkyl with carbon number 1-5; or R1 is selected from: alkyl with carbon number 1-5 substituted by cyano, hydroxyl.

2. The small molecule antistatic agent according to claim 1, characterized in that, The alkyl with carbon number 1-5 is selected from: methyl, ethyl, propyl.

3. The small molecule antistatic agent according to claim 1, wherein The antistatic agent is any one of the compounds shown in the following structures: ； 。 4. An antistatic medical gauze, characterized by, The antistatic medical gauze comprises the antistatic agent according to any one of claims 1-3.

5. The anti-static medical gauze according to claim 4, characterized in that, The antistatic medical gauze comprises the following raw materials by mass: cotton fiber 60-80 parts, antistatic agent 1-5 parts, water-soluble polymer 5-15 parts, antibacterial agent 0.5-1 part.

6. The anti-static medical gauze according to claim 5, characterized in that, The cotton fiber is combed cotton with fiber length of 25-35 mm.

7. The anti-static medical gauze according to claim 5, characterized in that, The water-soluble polymer is selected from polyvinyl alcohol or sodium carboxymethyl cellulose.

8. The anti-static medical gauze according to claim 5, characterized in that, The antibacterial agent is selected from cetyltrimethylammonium bromide or benzalkonium chloride.

9. A method of producing an antistatic medical gauze according to any one of claims 4 to 8, characterized by, The method comprises the following steps: (1) mixing the antistatic agent, water-soluble polymer and antibacterial agent in water to form solution A; (2) immersing the cotton fiber in the solution A to ensure sufficient penetration to obtain soaked cotton fiber; (3) drying the soaked cotton fiber at 40-65 ℃ to prepare modified cotton fiber; (4) weaving the modified cotton fiber to prepare medical gauze.

10. The method of claim 9, wherein the antistatic medical gauze is prepared by adding 0.1 to 0.5 parts by weight of the antistatic agent to 100 parts by weight of the cellulose fiber. The weaving in step (4) uses a circular weaving machine or a flat weaving machine to weave the medical gauze into a plain weave structure or a mesh structure, wherein the mesh density is 10-20 meshes per square centimeter.

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