Liquid medicine processing stirring reaction equipment for western medicine production and processing

By modifying the structure of the stirring blades and the lifting components, the problem of uneven mixing of high-viscosity syrup was solved, achieving uniform mixing of the medicinal liquid components and ensuring the stability of the medicinal liquid quality.

CN120919949APending Publication Date: 2025-11-11STADA PHARM (BEIJING) LTD
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Patent Information

Application Number
CN202511408077.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-09-29
Publication Date
2025-11-11

AI Technical Summary

Technical Problem

Existing pharmaceutical production and processing equipment suffers from high stirring resistance when handling highly viscous syrups, leading to uneven drug composition, affecting efficacy, or posing dosage risks.

Method used

A pharmaceutical liquid stirring and reaction device for the production and processing of Western medicine was designed. By modifying the stirring blade structure, adding inclined convex plates and multiple sets of stirring blade arrays, and combining lifting components and gear transmission, the device can effectively stir and uniformly mix high-viscosity syrups.

Benefits of technology

This process achieves thorough mixing of the highly viscous syrup, rapid fusion of the powder and syrup, ensures uniformity of the drug solution composition, prevents powder accumulation, and improves the stability of the drug solution quality.

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Abstract

The invention relates to the technical field of liquid medicine processing, in particular to liquid medicine processing, stirring and reacting equipment for western medicine production and processing, which comprises a frame assembly comprising a support frame, a power mechanism arranged on the outer wall of the support frame and a transmission mechanism arranged on the outer wall of the power mechanism; the stirring assembly comprises a transmission shaft arranged on the outer wall of the transmission mechanism, a stirring shaft arranged at the end part of the transmission shaft, a circular ring arranged on the outer wall of the stirring shaft, and a connecting rod arranged on the outer wall of the circular ring. According to the syrup stirring device, the stirring blades are arranged, so that the stirring blades can be opened during contact according to the characteristics of syrup, the stirring blades can conveniently exert the optimal stirring range, stirring is more sufficient, meanwhile, medicine powder and syrup stirring medicine powder can be firstly stacked at the top, the upper half part of the syrup is firstly stirred through the stirring blades, and the medicine powder and the syrup can be rapidly fused.
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Description

Technical Field

[0001] This invention relates to the field of pharmaceutical liquid processing technology, and in particular to a pharmaceutical liquid processing stirring and reaction device for the production and processing of Western medicine. Background Technology

[0002] This equipment is a processing and stirring reaction device for pharmaceutical solutions used in the production and processing of Western medicines. It is a core piece of equipment specifically designed for the physical mixing, dissolution, dispersion, and chemical reaction requirements of syrup-type pharmaceutical solutions. Equipped with a stirring device adapted to high-viscosity fluids, it can achieve uniform mixing of various components in the pharmaceutical solution and full dissolution and stable dispersion of the active pharmaceutical ingredients by precisely controlling the stirring speed, temperature, stirring time, and reaction pressure. This ensures that the syrup-type pharmaceutical solutions meet the quality standards of Western medicines during the production process and provide qualified intermediate products for subsequent processes such as filtration and filling.

[0003] During the use of processing and stirring reaction equipment, high-viscosity syrups will significantly increase stirring resistance. If the design of the stirring paddle is not suitable, the syrup may adhere to the stirring shaft and cannot be effectively rolled into the stirring process. This will result in incomplete dissolution of solid raw materials and uneven dispersion of active pharmaceutical ingredients, ultimately causing deviations in drug concentration, affecting efficacy or causing dosage risks.

[0004] Based on this, the present invention designs a pharmaceutical liquid processing stirring reaction device for the production and processing of Western medicine to solve the above problems. Summary of the Invention

[0005] In view of the problems existing in the above or prior art, the present invention is proposed.

[0006] Therefore, the purpose of this invention is to provide a stirring and reaction apparatus for processing pharmaceutical solutions in the production and processing of Western medicines.

[0007] As a pharmaceutical liquid processing and stirring reaction device for the production and processing of Western medicine according to the present invention, it includes,

[0008] A frame assembly includes a support frame, a power mechanism disposed on the outer wall of the support frame, and a transmission mechanism disposed on the outer wall of the power mechanism; and,

[0009] The stirring assembly includes a drive shaft disposed on the outer wall of the transmission mechanism, a stirring shaft disposed at the end of the drive shaft, a ring disposed on the outer wall of the stirring shaft, a connecting rod disposed on the outer wall of the ring, a first stirring blade disposed at the end of the connecting rod, and a protrusion disposed on the outer wall of the first stirring blade; and,

[0010] The lifting assembly includes a threaded rod disposed inside the stirring shaft, a gear disposed inside the stirring shaft, a threaded tube disposed on the outer wall of the gear, and a circular rack disposed inside the stirring shaft.

[0011] As a preferred embodiment of the pharmaceutical liquid processing and stirring reaction equipment for the production and processing of Western medicine according to the present invention, wherein: a stirring tank is provided outside the supporting frame, and the stirring shaft is provided inside the stirring tank.

[0012] As a preferred embodiment of the pharmaceutical liquid processing stirring reaction equipment for the production and processing of Western medicine according to the present invention, the outer wall of the stirring shaft is provided with a sliding groove, and the inside of the sliding groove is provided with a sliding rod.

[0013] As a preferred embodiment of the pharmaceutical liquid processing stirring reaction equipment for the production and processing of Western medicine according to the present invention, wherein: the outer wall of the slide bar is provided with a second stirring blade, and the second stirring blade is disposed on the first stirring blade.

[0014] As a preferred embodiment of the pharmaceutical liquid processing stirring reaction equipment for the production and processing of Western medicine according to the present invention, the chute is configured in multiple groups and arranged in a ring array, and the first stirring blade is configured in multiple groups and arranged in a ring array.

[0015] As a preferred embodiment of the pharmaceutical liquid processing stirring reaction equipment for the production and processing of Western medicine according to the present invention, wherein: a rotating rod is provided inside the stirring shaft, and the gear is provided at the end of the rotating rod.

[0016] As a preferred embodiment of the pharmaceutical liquid processing and stirring reaction equipment for the production and processing of Western medicine according to the present invention, the gear is meshed with a ring rack, and the threaded rod is meshed with a threaded pipe.

[0017] As a preferred embodiment of the pharmaceutical liquid processing and stirring reaction equipment for the production and processing of Western medicine according to the present invention, the outer wall of the threaded rod is provided with a cross plate, the bottom of the stirring shaft is provided with a cross groove, and the cross plate is disposed in the cross groove of the stirring shaft.

[0018] As a preferred embodiment of the pharmaceutical liquid processing and stirring reaction equipment for the production and processing of Western medicine according to the present invention, wherein: a spring is provided on the outer wall of the threaded rod, and the spring is disposed inside the stirring shaft.

[0019] In a preferred embodiment of the pharmaceutical liquid processing and stirring reaction equipment of the present invention, the circular ring is disposed at the end of the cross plate.

[0020] The beneficial effects of the pharmaceutical liquid processing and stirring reaction equipment of the present invention are as follows: Due to the extremely high viscosity of the syrup, the stirring blades are modified by adding an inclined convex plate, which can expand upon contact with the syrup, allowing the stirring blades to achieve the optimal stirring range and resulting in more thorough mixing. Simultaneously, the powder initially accumulates at the top of the syrup, and the stirring blades first stir the upper part of the syrup, allowing the powder and syrup to quickly blend. As the stirring blades descend, all the syrup is stirred, preventing excessive accumulation of powder and ensuring a more uniform medicinal effect. Attached Figure Description

[0021] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the following description of the embodiments will be briefly introduced. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0022] Figure 1 This is a schematic diagram of the overall structure of a pharmaceutical liquid processing stirring reaction device for the production and processing of Western medicine according to the present invention;

[0023] Figure 2 This is a schematic diagram of the main structure of a pharmaceutical liquid processing stirring reaction device for the production and processing of Western medicine according to the present invention;

[0024] Figure 3 This is a schematic diagram of the stirring assembly structure of a pharmaceutical liquid processing and stirring reaction device for the production and processing of Western medicine according to the present invention;

[0025] Figure 4 This is a schematic diagram of the main structure of the stirring assembly of a pharmaceutical liquid processing and reaction device for the production and processing of Western medicine according to the present invention;

[0026] Figure 5 This is a schematic diagram showing the disassembled structure of the stirring assembly of a pharmaceutical liquid processing and reaction device for the production and processing of Western medicine according to the present invention;

[0027] Figure 6 This is a schematic diagram of the internal structure of the lifting assembly of a pharmaceutical liquid processing and stirring reaction device for the production and processing of Western medicine according to the present invention;

[0028] Figure 7 This is a schematic diagram of the disassembled lifting assembly of a pharmaceutical liquid processing and stirring reaction device for the production and processing of Western medicine according to the present invention.

[0029] The labels in the diagram represent: 100, frame assembly; 101, support frame; 102, power mechanism; 103, transmission mechanism; 104, mixing tank; 200, mixing assembly; 201, drive shaft; 202, mixing shaft; 203, ring; 204, connecting rod; 205, first mixing blade; 206, convex plate; 207, chute; 208, slide rod; 209, second mixing blade; 300, lifting assembly; 301, cross plate; 302, spring; 303, threaded rod; 304, rotating rod; 305, gear; 306, ring rack; 307, threaded pipe. Detailed Implementation

[0030] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0031] Many specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention may also be practiced in other ways different from those described herein, and those skilled in the art can make similar extensions without departing from the spirit of the invention. Therefore, the invention is not limited to the specific embodiments disclosed below.

[0032] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in different places in this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that is mutually exclusive with other embodiments.

[0033] Example 1, referring to Figures 1 to 7 This is the first embodiment of the present invention. This embodiment provides a pharmaceutical liquid processing stirring reaction device for the production and processing of Western medicine, including a frame assembly 100, which includes a support frame 101, a power mechanism 102 disposed on the outer wall of the support frame 101, and a transmission mechanism 103 disposed on the outer wall of the power mechanism 102. The power mechanism 102 is fixedly installed in the middle of the support frame 101 and is used to provide power to the stirring device. The transmission mechanism 103 is fixedly installed at the output end of the servo motor of the power mechanism 102 and is used to transmit the output power.

[0034] Furthermore, the stirring assembly 200 includes a drive shaft 201 disposed on the outer wall of the transmission mechanism 103, the drive shaft 201 being fixedly installed at the end of the transmission mechanism 103 for transmission, a stirring shaft 202 disposed on the end of the drive shaft 201, the stirring shaft 202 being fixedly installed at the end of the drive shaft 201, a ring 203 disposed on the outer wall of the stirring shaft 202, the ring 203 moving up and down at the bottom of the stirring shaft 202, and a connecting rod 204 disposed on the outer wall of the ring 203. 204 is rotatably installed in the middle of the ring 203. The connecting rod 204 rotates on the ring 203. The first stirring blade 205 and the convex plate 206 are provided on the outer wall of the first stirring blade 205. The first stirring blade 20 is fixedly installed at the end of the connecting rod 20, and the convex plate 206 is fixedly installed at the end of the first stirring blade 205. The convex plate 206 is installed at a certain angle to the first stirring blade 205, so that the first stirring blade 205 can be more easily supported when it comes into contact with the liquid medicine.

[0035] Furthermore, the lifting assembly 300 includes a threaded rod 303 disposed inside the stirring shaft 202, the threaded rod 303 moving up and down inside the stirring shaft 202, a gear 305 disposed inside the stirring shaft 202, the gear 305 rotating inside the stirring shaft 202, a threaded tube 307 disposed on the outer wall of the gear 305, and a ring rack 306 disposed inside the stirring shaft 202. The threaded tube 307 is fixedly installed at the bottom of the gear 305, and the ring rack 306 is fixedly installed inside the stirring shaft 202.

[0036] In use, the stirring shaft 202 is placed inside the stirring tank 104 filled with syrup. When the first stirring blade 205 comes into contact with the syrup, due to the extremely high viscosity of the syrup, the tilt of the convex plate 206 can open the first stirring blade 205. As the stirring shaft 202 continues to enter, the angle at which the first stirring blade 205 is opened by the syrup gradually increases, and at the same time, the second stirring blade 209 is also opened. After the stirring shaft 202 is fully inside, the medicated powder is added to prepare for stirring. At this time, the powder is at the top of the syrup. After stirring is started, the first stirring blade 205, which has been opened, will... 5. The centrifugal force causes the mixture to change to a horizontal state, which in turn helps the second stirring blade 209 to stir the powder and syrup. At this time, the ring rack 306 inside the stirring shaft 202 rotates. Through the meshing transmission of the ring rack 306 and the gear 305, the gear 305 drives the threaded tube 307 to rotate. The rotating threaded tube 307 causes the threaded rod 303 to move downward through meshing transmission. The threaded rod 303 drives the ring 203 to move downward. As the threaded rod 303 continues to move downward, the stirring position of the first stirring blade 205 and the second stirring blade 209 moves downward.

[0037] In summary, by modifying the stirring blades due to the extremely high viscosity of the syrup, and adding an inclined installation of the convex plate 206, the blades can be expanded upon contact with the syrup, allowing the stirring blades to achieve the optimal stirring range and resulting in more thorough mixing. Simultaneously, the powder initially accumulates at the top of the syrup, and the stirring blades first stir the upper part of the syrup, enabling the powder and syrup to quickly blend. As the stirring blades descend, all the syrup is then stirred, preventing excessive accumulation of powder and ensuring a more uniform medicinal effect.

[0038] Example 2, refer to Figures 1-5 This is the second embodiment of the present invention. Unlike the previous embodiment, this embodiment solves the problem of how to spread the stirring blade. It includes a stirring tank 104 disposed outside the support frame 101, a syrup-like liquid disposed inside the stirring tank 104, and a stirring shaft 202 disposed inside the stirring tank 104.

[0039] Furthermore, a groove 207 is provided on the outer wall of the stirring shaft 202. The groove 207 is fixedly installed on the outer wall of the stirring shaft 202. A slide rod 208 is provided inside the groove 207. The slide rod 208 is slidably installed inside the groove 207.

[0040] Furthermore, a second stirring blade 209 is provided on the outer wall of the slide rod 208. The second stirring blade 209 is rotatably mounted on the slide rod 208 and is disposed on the first stirring blade 205. The second stirring blade 209 and the first stirring blade 205 are mounted by a rotating shaft.

[0041] Furthermore, the chute 207 is configured in multiple groups and arranged in a ring array, and the first stirring blade 205 is configured in multiple groups and arranged in a ring array. The chute 207 and the first stirring blade 205 are four groups and distributed around the stirring shaft 202.

[0042] During use, as the first stirring blade 205 enters the syrup and is gradually expanded, the first stirring blade 205 will cause the second stirring blade 209 to move upward through the rotating shaft. The top of the second stirring blade 209 is inside the chute 207. Therefore, a triangle is gradually formed between the first stirring blade 205, the second stirring blade 209 and the stirring shaft 202. Then, as the stirring starts, the first stirring blade 205 is in a horizontal state due to the influence of centrifugal force. Finally, a near-right-angled triangle is formed between the first stirring blade 205, the second stirring blade 209 and the stirring shaft 202.

[0043] In summary, by changing the angle between the first stirring blade 205, the second stirring blade 209, and the stirring shaft 202, the stirring area at the top is small during stirring, thus preventing excessive shaking at the top and splashing of the medicine. At the same time, after stirring, a large amount of syrup will remain on the stirring blades. At this time, the first stirring blade 205 will move downwards, and the second stirring blade 209 will begin to retract into the groove 207. The syrup will be squeezed out of the second stirring blade 209 by the groove 207, thus preventing the stirring blades from carrying out a large amount of medicine after stirring and facilitating the cleaning of the stirring blades.

[0044] Example 3, referring to Figures 6-7 This is the third embodiment of the present invention. Unlike the previous embodiment, this embodiment solves the problem of how to raise and lower the stirring rod during the stirring process. It includes a rotating rod 304 disposed inside the stirring shaft 202. The rotating rod 304 is rotatably installed at the top end inside the stirring shaft 202. A gear 305 is disposed at the end of the rotating rod 304. The bottom of the rotating rod 304 is fixedly connected to the gear 305.

[0045] Furthermore, gear 305 is meshed with ring rack 306, and ring rack 306 meshes with gear 305 for transmission. Threaded rod 303 is meshed with threaded tube 307, and threaded tube 307 meshes with threaded rod 303 for transmission.

[0046] Furthermore, a cross plate 301 is provided on the outer wall of the threaded rod 303. The cross plate 301 is fixedly installed at the bottom of the threaded rod 303. A cross groove is provided at the bottom of the stirring shaft 202. The cross groove is opened in the middle of the bottom end of the stirring shaft 202. The cross plate 301 is set in the cross groove of the stirring shaft 202 and is slidably installed in the cross groove of the stirring shaft 202.

[0047] Furthermore, a spring 302 is provided on the outer wall of the threaded rod 303, and a spring 302 is fixedly installed at the bottom of the threaded rod 303. The spring 302 is located inside the stirring shaft 202 and is fixedly installed at the bottom of the stirring shaft 202.

[0048] Furthermore, the ring 203 is disposed at the end of the cross plate 301, and the ring 203 is fixedly installed at the bottom end of the cross plate 301.

[0049] When in use, the threaded rod 303 moves by sliding in the bottom cross groove through the cross plate 301, which at the same time creates a limiting effect to ensure that it can achieve dynamic adjustment in the vertical direction. When the threaded rod 303 descends to the bottom, the threaded tube 307 will rotate in the unthreaded area at the top of the threaded rod 303 to ensure that it will not be affected by meshing at the bottom. After the stirring is finished, the spring 302 will push the threaded area of ​​the threaded rod 303 back to the threaded tube, and then the threaded rod 303 will rise by rotating in the opposite direction.

[0050] In summary, the stirring blade initially acts on the upper part of the syrup. This design utilizes the vortex effect generated by stirring to quickly break up the initial stratification of the powder and syrup, promoting the rapid diffusion and initial fusion of solid powder particles in the liquid syrup, significantly shortening the initial mixing time. As the stirring blade gradually moves downwards, its stirring range also expands to the middle and lower parts of the syrup. This top-down progressive stirring method effectively avoids the problem of excessive accumulation of powder at the bottom of the container due to gravity, forming clumps. Once the stirring blade completely covers the entire syrup system, continuous three-dimensional stirring allows the powder particles to be more evenly dispersed in every part of the syrup, ensuring a high degree of consistency in the syrup's component distribution, thereby guaranteeing the stability and uniformity of the final product's medicinal properties.

[0051] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A pharmaceutical liquid processing and stirring reaction device for the production and processing of Western medicine, characterized in that: include, The frame assembly (100) includes a support frame (101), a power mechanism (102) disposed on the outer wall of the support frame (101), and a transmission mechanism (103) disposed on the outer wall of the power mechanism (102); and, The stirring assembly (200) includes a drive shaft (201) disposed on the outer wall of the transmission mechanism (103), a stirring shaft (202) disposed at the end of the drive shaft (201), a ring (203) disposed on the outer wall of the stirring shaft (202), a connecting rod (204) disposed on the outer wall of the ring (203), a first stirring blade (205) disposed at the end of the connecting rod (204), and a protruding plate (206) disposed on the outer wall of the first stirring blade (205); and, The lifting assembly (300) includes a threaded rod (303) disposed inside the stirring shaft (202), a gear (305) disposed inside the stirring shaft (202), a threaded tube (307) disposed on the outer wall of the gear (305), and a ring rack (306) disposed inside the stirring shaft (202).

2. The pharmaceutical liquid processing and stirring reaction equipment for the production and processing of Western medicine according to claim 1, characterized in that, The support frame (101) is provided with a stirring tank (104) on the outside, and the stirring shaft (202) is provided inside the stirring tank (104).

3. The pharmaceutical liquid processing and stirring reaction equipment for the production and processing of Western medicine according to claim 2, characterized in that, The outer wall of the stirring shaft (202) is provided with a groove (207), and a slide rod (208) is provided inside the groove (207).

4. The pharmaceutical liquid processing and stirring reaction equipment for the production and processing of Western medicine according to claim 3, characterized in that, The outer wall of the slide bar (208) is provided with a second stirring blade (209), which is disposed on the first stirring blade (205).

5. The pharmaceutical liquid processing and stirring reaction equipment for the production and processing of Western medicine according to claim 4, characterized in that, The chute (207) is configured in multiple groups and arranged in a ring array, and the first stirring blade (205) is configured in multiple groups and arranged in a ring array.

6. The pharmaceutical liquid processing and stirring reaction equipment for the production and processing of Western medicine according to claim 5, characterized in that, The stirring shaft (202) is equipped with a rotating rod (304), and the gear (305) is located at the end of the rotating rod (304).

7. The pharmaceutical liquid processing and stirring reaction equipment for the production and processing of Western medicine according to claim 6, characterized in that, The gear (305) is meshed with the ring rack (306), and the threaded rod (303) is meshed with the threaded tube (307).

8. The pharmaceutical liquid processing and stirring reaction equipment for the production and processing of Western medicine according to claim 7, characterized in that, The outer wall of the threaded rod (303) is provided with a cross plate (301), and the bottom of the stirring shaft (202) is provided with a cross groove. The cross plate (301) is located in the cross groove of the stirring shaft (202).

9. The pharmaceutical liquid processing and stirring reaction equipment for the production and processing of Western medicine according to claim 8, characterized in that, A spring (302) is provided on the outer wall of the threaded rod (303), and the spring (302) is located inside the stirring shaft (202).

10. The pharmaceutical liquid processing and stirring reaction equipment for the production and processing of Western medicine according to claim 9, characterized in that, The ring (203) is disposed at the end of the cross plate (301).