Prothioconazole, flutolanil and clothianidin seed treatment suspending agent as well as preparation method and application thereof

Abstract

The invention provides a prothioconazole, flutolanil and clothianidin seed treatment suspending agent and a preparation method thereof. According to the seed treatment suspending agent, a compound thickening agent is used and is matched with a specific anti-freezing agent, and proper raw material adding sequence and preparation steps as well as process parameters such as shearing time and grinding temperature are determined, so that the conditions of huddling or caking, poor preparation stability, poor film-forming property and the like which are easy to occur in the preparation process of the seed treatment suspending agent are avoided; the method is suitable for large-scale industrial production. The seed treatment suspending agent disclosed by the invention is good in stability, can be used for preventing and treating wheat root rot and wheat aphids, and is remarkable in pesticide effect.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of pesticide preparation, and particularly relates to a prothioconazole·flutolanil·clothianidin seed treatment suspending agent as well as a preparation method and application thereof. BACKGROUND

[0002] Seed treatment suspending agent is the most widely used and largest amount of seed coating agent in the promotion of seed coating technology in China. It is a special functional pesticide water suspending agent prepared by ultrafine grinding solid pesticides and other auxiliary ingredients to a certain fineness range and adding a film forming agent. The auxiliary agents used in the seed treatment suspending agent are various, and the main auxiliary agents include dispersants, wetting agents, film forming agents, thickening agents, antifreeze agents, preservatives, etc. Stirring, grinding and other processes are needed in the preparation process, and the process parameters are relatively difficult to control. If the auxiliary agent is not properly selected or the process parameters are not reasonable, the active ingredient may be decomposed, and the flowability, stability and efficacy of the preparation may be affected.

[0003] Prothioconazole has the molecular formula C14H17Cl2N3O2S, the chemical name (RS)-2-(2-chlorophenyl)-1-(4-chlorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol, and is a colorless crystalline solid with a melting point of about 70℃ and a boiling point of about 350℃. The density is about 1.4 g / cm3. It has high solubility in organic solvents such as acetone, methanol and ethanol, and low solubility in water. Prothioconazole is a triazole thione fungicide that can effectively control higher fungal diseases, including some soil-borne diseases such as white thread disease and basal stem rot. The systemic control effect is more obvious than traditional triazole fungicides, and it is safe and has lower activity to inhibit plant growth than common triazole fungicides such as tebuconazole and propiconazole. It is mainly used to prevent and control many diseases of cereal crops such as wheat, barley, rapeseed, peanut, rice and legume crops. It has good control effect on almost all wheat diseases, such as powdery mildew, brown leaf spot, fusarium wilt, leaf spot, rust, root rot, sclerotinia, net blotch and cloud spot of wheat and barley. The common dosage forms at present include suspending agent, emulsion, etc.

[0004] Flutolanil, molecular formula C17H16F3NO2, chemical name: 3'-isopropoxy-2-(trifluoromethyl) benzamide, pure product is colorless and odorless crystalline solid, melting point 102-105℃, boiling point 339.13℃, density 1.247g / cm3(20℃). Poorly soluble in water, easily soluble in toluene, acetone, benzene and other organic solvents. Stable in acid and alkali, stable to light and heat. Flutolanil is a succinate dehydrogenase inhibitor, which is an internal-acting fungicide with protective and curative effects, mainly used for preventing and treating various damping-off, sheath blight, snow blight, white rot, rust and the like. Common dosage forms include seed treatment suspending agent, water dispersible granules and wettable powder and the like.

[0005] Clothianidin, molecular formula C6H8ClN5O2S, chemical name: (E)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine, the appearance of the original drug is crystalline solid powder, no smell, melting point 176.8-178.8℃, poor water solubility, certain solubility in acetone, methanol, ethyl acetate and other organic solvents. Clothianidin is a new neonicotinoid insecticide, which is widely used in rice, vegetables, fruit trees and other crops, and can prevent and control aphids, leafhoppers, thrips, planthoppers and other hemipterans, coleopterans, dipterans and some lepidopterans, and can also be used for preventing and controlling mole crickets, grubs, wireworms, and ground beetles. Common dosage forms include wettable powder, water dispersible granules, suspending agent and the like.

[0006] Chinese patent application CN103238618A discloses a seed treatment composition containing clothianidin, which discloses the technical scheme of compounding clothianidin and prothioconazole, and also discloses that the composition can be made into a suspending seed coating agent, but the application focuses on the synergistic effect of active ingredient compounding on rice planthoppers, and does not focus on specific formulations, does not disclose the specific formula and related quality control indicators of the suspending seed coating agent, and does not disclose that the composition can be used for preventing and treating wheat pests. SUMMARY

[0007] Based on the prior art, in order to expand the prevention and treatment spectrum of the composition and develop a stable seed treatment composition, the present application provides a prothioconazole·flutolanil·clothianidin seed treatment suspending agent, characterized in that it contains, by mass percentage, 1.5-4% of prothioconazole, 1.5-4% of flutolanil, 25-35% of clothianidin, 3-8% of dispersing agent, 1-3% of wetting agent, 0.4-1% of film forming agent, 0.8-1.5% of thickening agent, 2-5% of antifreeze agent, 0.1-0.5% of defoaming agent, 0.1-0.5% of preservative, 5-10% of warning color, and deionized water to make up 100%. The thickening agent is compounded by xanthan gum and magnesium aluminum silicate, and the antifreezing agent is ethylene glycol, wherein the mass ratio of xanthan gum to magnesium aluminum silicate is 0.1-0.2:0.6-1.2, and the mass ratio of xanthan gum to ethylene glycol is 0.1-0.2:4.

[0008] Preferably, the dispersant can be selected from one or more of polycarboxylate, phosphate ester, polyether sulfate, lignin sulfonate, alkyl naphthalene formaldehyde condensate sulfonate, sodium lauryl polyoxyethylene ether sulfate, phenylethyl phenol phosphate ester, cresol-formaldehyde sodium salt concentrate, sodium dodecyl sulfate, ethoxyphenol ether sulfonate, modified polyacrylate copolymer, dodecyl polyoxyethylene ether phosphate, high molecular comb copolymer, and polyether sulfate polybasic complex.

[0009] Preferably, the wetting agent can be selected from one or more of EO-PO block copolymer, diisopropyl naphthalene sulfonate, fatty alcohol polyoxyethylene ether, dioctyl sulfonated sodium succinate, nonylphenol polyoxyethylene ether, alkyl polyoxyethylene ether, phenylethyl phenylpropyl phenol polyoxyethylene ether, pull-apart powder, and sodium dodecyl benzene sulfonate.

[0010] Preferably, the film-forming agent can be selected from one or more of polyvinyl alcohol, modified carboxypropyl cellulose, polyethylene glycol, rosin, benzene propyl emulsion, acrylic resin polymer, gelatin, sodium alginate, and the like.

[0011] Preferably, the defoaming agent can be selected from one or more of organosilicon, modified polyether, acetylenic diol, tributyl phosphate, butanol, C8-C10 fatty alcohol, and ester-ether type compound.

[0012] Preferably, the preservative can be selected from one or more of benzisothiazolinone, sodium benzoate, formaldehyde, polyformaldehyde, sodium citrate, sodium salicylate, potassium sorbate, and kasun.

[0013] Preferably, the warning color can be selected from one or more of acid scarlet, basic sky blue, basic tender yellow G, and curcumin.

[0014] The present application also provides a preparation method of the propiconazole·flutolanil·clothianidin seed treatment suspension agent, characterized in that the steps are as follows: (1) under shearing conditions, the wetting agent, the dispersant, and the defoaming agent are added to deionized water, shearing is continued, and propiconazole, flutolanil, and clothianidin are added, and shearing is continued; (2) First, xanthan gum is added into the anti-freezing agent ethylene glycol to be stirred and dispersed to form a dispersion liquid, and then the dispersion liquid is added into the mixture obtained in step (1) together with the preservative and another thickening agent magnesium aluminum silicate, and the shearing is continued to obtain a suspension slurry; (3) The suspension slurry obtained in step (2) is stirred uniformly under cooling conditions, and the temperature is controlled to carry out three-stage sand milling; (4) The product obtained in step (3) is transferred to a mixing kettle, the film-forming agent and the warning color are added, and shearing is uniformly carried out and is subjected to inspection, and if qualified, is packed; if not qualified, is further adjusted, and is subjected to inspection again until qualified and packed.

[0015] Preferably, the grinding process of step (3) needs to open the cooling device, and the temperature of the first-stage sand milling is controlled to be not more than 30℃, and the temperature of the second-stage and third-stage sand milling is controlled to be not more than 35℃.

[0016] The application also provides the use of the propiconazole · flutolanil · clothianidin seed treatment suspension concentrate in the prevention and treatment of agricultural diseases and insect pests, and the diseases and insect pests include wheat root rot and wheat aphids.

[0017] The qualified refers to the relevant quality control indexes in the Suspension Concentrate Product Standard Writing Specification (GB / T17768-1999) (for example, the quality control index detection data in the specific embodiment part of the present application).

[0018] Xanthan gum and magnesium aluminum silicate are both common thickening agents, and the physicochemical properties of the two are different. Xanthan gum can improve the viscosity of the suspension concentrate and inhibit the sedimentation of particles, but long-term storage may cause slight stratification due to gravity. Magnesium aluminum silicate swells to form a colloidal dispersion liquid when it comes into contact with water, and forms a weak gel structure when it is at rest, which can prevent the sedimentation of particles. The structure is destroyed and becomes thin under shearing force, and quickly recovers after the external force is removed. After the two are compounded in a certain proportion, xanthan gum provides basic viscosity, and magnesium aluminum silicate enhances thixotropy, which can balance the stability and processing performance of the preparation.

[0019] On the other hand, the present inventors have found in practice that if all components are added at the same time or the components are added in sequence without any order and stirred, the components tend to clump or agglomerate in the container, and it is difficult to shear to form a uniform suspension slurry. When the suspension slurry is transferred to the sand mill, a large amount of viscous material is left on the bottom and wall of the container, which is difficult to handle.

[0020] Without being bound by any theory, the present inventors believe that xanthan gum is easily soluble in water to form a high-viscosity solution, but is not soluble in organic solvents, while magnesium aluminum silicate swells to form a colloidal dispersion liquid when it comes into contact with water. The main reason for the clumping or agglomeration of the components is that both of them come into contact with water and organic solvents at the same time. Therefore, the present inventors have found that by optimizing the addition order and method of various components in the composition, the problem can be solved by dispersing xanthan gum in the anti-freezing agent ethylene glycol to form a dispersion liquid, and then adding the dispersion liquid together with magnesium aluminum silicate to the mixture of other components.

[0021] On the other hand, the present inventors have found in practice that the film-forming agent and the warning color should be added after grinding and uniformly dispersed by shearing, which can avoid the grinding from damaging the film-forming performance of the film-forming agent and the contamination of the sand mill by the color paste.

[0022] By adopting the technical scheme, the present application has the following beneficial effects: (1) The seed treatment suspension agent of the present application uses a compounded thickening agent, cooperates with a specific antifreezing agent, and through a large number of tests in the preparation process, determines the appropriate raw material adding sequence and preparation steps, as well as the process parameters such as shearing time and grinding temperature, which avoids the situations such as clumping or caking, poor formulation stability, and poor film-forming performance that are prone to occur in the preparation process of the seed treatment suspension agent, and is suitable for large-scale industrial production.

[0023] (2) The seed treatment suspension agent of the present application has good stability and can be used for preventing and treating wheat root rot and wheat aphids, and has remarkable efficacy. BRIEF DESCRIPTION OF DRAWINGS

[0024] In order to more clearly illustrate the specific embodiments of the present application or the technical solutions in the prior art, the drawings needed to be used in the specific embodiments or prior art description will be briefly introduced below. Obviously, the drawings in the following description are some embodiments of the present application, and other drawings can also be obtained by those skilled in the art without creative labor.

[0025] Figure 1 The process flow chart for producing the suspension paste of the formulation example 1 is shown in the figure. Figure 2 The process flow chart for grinding the production of the formulation example 1 is shown in the figure. DETAILED DESCRIPTION

[0026] The present application will be further explained and described below in combination with specific embodiments.

[0027] I. Formulation Example Example 1: 37% propiconazole · flutolanil · clothianidin seed treatment suspension agent Formulation composition:

[0028] The preparation method is as follows: (1) Under shearing conditions, add the phenylethyl phenol phosphate ester salt dispersant Soprophor SC, the high molecular comb copolymer dispersant Geropon DA1349, the dioctyl sulfonated sodium succinate wetting dispersant Geropon CYA / X, and the silicone defoaming agent into deionized water, continue to shear for 5 min, add propiconazole, flutolanil, and indoxacarb, continue to shear for 5 min to obtain a mixture; (2) Add thickening agent xanthan gum into anti-freezing agent ethylene glycol to disperse by stirring to form a dispersion, then add preservative BIT and thickening agent magnesium aluminum silicate into the mixture obtained in step (1) together with the dispersion, and continue to shear for 15 min to obtain a suspension slurry; (3) Start the cooling device, stir the suspension slurry obtained in step (2) uniformly, and control the temperature to carry out three-stage sanding, wherein the temperature of the first-stage sanding is not more than 30°C, and the temperatures of the second-stage and third-stage sanding are not more than 35°C; (4) Transfer the product obtained in step (3) to a mixing kettle, add film-forming agent SEMFIN METHOCEL E6 and warning color red paste big red N6503, and shear for 20 min before inspection. If qualified, pack; if not, further adjust, re-inspect until qualified and pack.

[0029] The preparation process flow chart is specifically shown in the following Figure 1 and 2 .

[0030] Example 2: 30% prothioconazole · flutolanil · clothianidin seed treatment suspension concentrate Formulation composition:

[0031] The preparation method is as follows: (1) Under shearing conditions, add sodium lauryl polyoxyethylene ether sulfate dispersant, nonylphenol polyoxyethylene ether wetting agent, and silicone defoaming agent into deionized water, continue to shear for 5 min, add prothioconazole, flutolanil, and clothianidin, and continue to shear for 5 min to obtain a mixture; (2) Add thickening agent xanthan gum into anti-freezing agent ethylene glycol to disperse by stirring to form a dispersion, then add preservative BIT and thickening agent magnesium aluminum silicate into the mixture obtained in step (1) together with the dispersion, and continue to shear for 15 min to obtain a suspension slurry; (3) Start the cooling device, stir the suspension slurry obtained in step (2) uniformly, and control the temperature to carry out three-stage sanding, wherein the temperature of the first-stage sanding is not more than 30°C, and the temperatures of the second-stage and third-stage sanding are not more than 35°C; (4) Transfer the product obtained in step (3) to a mixing kettle, add film-forming agent and warning color, shear uniformly and inspect, and if qualified, pack; if not, further adjust, re-inspect until qualified and pack.

[0032] Example 3: 43% prothioconazole · flutolanil · clothianidin seed treatment suspension concentrate Formulation composition:

[0033] The preparation method is as follows: (1) Under shearing condition, add alkyl naphthalene formaldehyde condensate sodium sulfonate dispersant, fatty alcohol polyoxyethylene ether wetting agent, silicone antifoaming agent into deionized water, continue shearing for 5 min, add prothioconazole, flutolanil and nitenpyram, continue shearing for 5 min to obtain a mixture; (2) Add thickening agent xanthan gum into anti-freezing agent ethylene glycol, stir and disperse to form a dispersion, then add the dispersion into the mixture obtained in step (1) together with preservative BIT and thickening agent magnesium aluminum silicate, continue shearing for 15 min to obtain a suspension slurry; (3) Start the cooling device, stir the suspension slurry obtained in step (2) uniformly, and control the temperature to perform three-stage sand milling to obtain the finished product, wherein the temperature of the first-stage sand milling is not more than 30℃, and the temperature of the second-stage and third-stage sand milling is not more than 35℃; (4) Transfer the product obtained in step (3) into a mixing kettle, add film forming agent and warning color, shear uniformly and send for inspection, and if qualified, package; if not qualified, further adjust, send for inspection again until qualified and package.

[0034] Comparative Example 1: Prepare the product of Comparative Example 1 according to the formula of Example 1, and the preparation method is different, i.e. under shearing condition, add all components into a stirring container, and stir and shear. Then, transfer the prepared suspension slurry into a sand mill, and continue to perform steps (3) and (4) of the preparation method. As mentioned above, there are more blocky materials remaining at the bottom of the stirring container.

[0035] Comparative Example 2: Prepare the product of Comparative Example 1 according to the formula of Example 1, and the preparation method is different, i.e. in step (2), after adding preservative BIT and thickening agent magnesium aluminum silicate, continue to add film forming agent and warning color, shear to obtain a suspension slurry. Then, continue to perform steps (3) and (4), wherein step (4) does not add film forming agent and warning color.

[0036] II. Quality control index detection Prepare multiple batches of samples of Example and Comparative Example, and detect the content of active ingredient, suspension rate, pH value and other common indexes of pesticide suspending agent.

[0037] The index data of samples of Example 1-3 are shown in the following table:

[0038] From the above data, it can be seen that the sample of the embodiment of the present application meets the general requirements of the pesticide suspension agent. The best embodiment of the present application is Example 1, in which the selection and ratio of the active ingredient, dispersant and thickening agent in the formula are reasonable, so that the suspension rate of the active ingredient is all above 95%; Examples 2 and 3 use other dispersants, and the overall effect of the preparation formula is not as good as that of Example 1, and the suspension rate of the active ingredient is slightly lower, but also exceeds 90%, meeting the general requirements of the pesticide suspension agent.

[0039] Through detection, the content of the active ingredient in the sample of Comparative Example 1 is significantly reduced, propiconazole is 1.4±0.3%, fluazamide is 1.5±0.2%, and clothianidin is 21±3.3%. Without being bound by any theory, the inventors believe that the reason is that the two thickening agents fail to disperse sufficiently, resulting in the components clumping in the container, which is difficult to shear to form a uniform suspension slurry. When transferred to the sand mill, a large amount of material is left on the bottom and wall of the container.

[0040] III. Detection of coating performance of the preparation Wheat seeds are treated with the samples of Example 1 and Comparative Example 2, and the dosage of the pesticide is 200 mL / 100 kg of seeds, which is diluted 50 times during coating. According to the product standard writing specification of the suspension seed coating agent (GB / T17768-1999), visual and optical microscopic observation is performed to observe the uniformity of coating, and the film formation time and film formation stability are measured.

[0041] The film formation time is measured as follows: 1 kg of seeds is selected, and after coating, it is immediately laid flat for observation, and the timing is started until all the seed surfaces are uniformly solidified.

[0042] The film formation stability includes the coating shedding rate and the coating water resistance, etc., wherein the coating shedding rate is that the coated seeds are placed in a friction tester, the friction frequency and pressure are set, the shedding of the film layer after friction is observed, and the shedding rate is calculated, the shedding rate=(the amount of drug shed after friction / the initial amount of coated drug)×100%. The coating water resistance is measured as follows: 1 kg of coated seeds is selected, and immersed in deionized water (25℃), the morphological changes of the film layer after 14 days of immersion are observed by optical microscope, the film layer damage rate is measured, and the film layer damage rate=(damaged area / total surface area)×100%.

[0043] The test results are as follows:

[0044] Without being bound by any theory, the inventors believe that in the preparation process of the sample of Comparative Example 2, the film former is added before grinding, and the violent friction during grinding destroys the chemical structure of the film former, resulting in the reduction of the viscosity of the seed treatment suspension agent, the extension of the film formation time, and the easy adhesion of the coated seeds during the process of standing and drying. In addition, the dense structure of the film layer is destroyed, the mechanical strength is reduced, the wear resistance is reduced, the coating shedding rate is increased, and the water resistance is reduced.

[0045] IV. Drug Efficacy Test 1. Seed germination test Referencing the Crop Seed Inspection Procedure: Germination Test (GB / T 3543.4-1995), the germination rate, germination potential, and average germination time of coated wheat seeds were determined, with water-treated seeds used as a blank control.

[0046] Wheat variety: Zhengmai 1860. Wheat seeds were treated with the sample from Example 1. The dosage of the agent was 200 mL / 100 kg of seeds, diluted 50 times during coating.

[0047] Experimental replication: 3 replicates, 100 seeds each time.

[0048] Culture conditions: 25℃ constant temperature incubator, 12h light exposure / 12h darkness, filter paper for moisture retention.

[0049] The test results are as follows:

[0050] The experimental results showed that after treatment with the seed treatment suspension in Example 1, wheat seeds showed no significant difference in germination rate, germination potential, and germination time compared with the water control, and no phytotoxicity was caused.

[0051] 2. Field trials Experiment time and location: October 2023 - June 2024, Suiping County, Zhumadian City, Henan Province.

[0052] Wheat variety: Zhengmai 1860.

[0053] Test agents: Seed treatment suspensions of Examples 1-3, commercially available 25% prothioconazole suspension, 20% fluopyram wettable powder, and 48% thiamethoxam suspension, with a dosage of 200 mL (g) / 100 kg of seeds, diluted 50 times during treatment.

[0054] Experimental design: randomized block design, 3 replicates, plot area 20 m², row length 5 m, row spacing 25 cm, seeding rate 15 kg / mu.

[0055] Experimental conditions: Soil type: sandy black soil; pH: 6.8; Organic matter content: 1.2%; Pest and disease situation was investigated 60 days after sowing: natural incidence of root rot was 25.6%; Aphid population was 82 per 100 plants. Experimental results:

[0056] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A seed treatment suspension of prothioconazole·flufenamide·thiamethoxam, characterized in that, By weight percentage, it contains 1.5-4% prothioconazole, 1.5-4% fluopyram, 25-35% thiamethoxam, 3-8% dispersant, 1-3% wetting agent, 0.4-1% film-forming agent, 0.8-1.5% thickener, 2-5% antifreeze, 0.1-0.5% defoamer, 0.1-0.5% preservative, 5-10% warning color, and deionized water to make up to 100%. The thickener is a compound of xanthan gum and magnesium aluminum silicate, and the antifreeze is ethylene glycol. The mass ratio of xanthan gum to magnesium aluminum silicate is 0.1-0.2:0.6-1.2, and the mass ratio of xanthan gum to ethylene glycol is 0.1-0.2:

4.

2. The seed treatment suspension concentrate of prothioconazole·flufenamide·thiamethoxam according to claim 1, characterized in that, The dispersant may be selected from one or more of the following: polycarboxylates, phosphates, polyether sulfates, lignin sulfonates, alkylnaphthalene formaldehyde condensate sulfonates, sodium lauryl polyoxyethylene ether sulfate, phenethylphenol phosphate salts, cresol-formaldehyde sodium salt concentrates, sodium dodecyl sulfate, ethoxyphenol ether sulfonates, modified polyacrylate copolymers, dodecyl polyoxyethylene ether phosphates, high molecular weight comb copolymers, and sulfate polyether multi-component complexes.

3. The seed treatment suspension agent of prothioconazole·flufenamide·thiamethoxam according to claim 2, characterized in that, The dispersant is a mixture of phenylethylphenol phosphate salt and a high molecular weight comb copolymer in a mass ratio of 2:

3.

4. The seed treatment suspension concentrate of prothioconazole·flufenamide·thiamethoxam according to claim 1, characterized in that, The wetting agent may be selected from one or more of the following: EO-PO block copolymer, diisopropylnaphthalene sulfonate, fatty alcohol polyoxyethylene ether, sodium dioctyl sulfonate, nonylphenol polyoxyethylene ether, alkyl polyoxyethylene ether, phenylethyl phenylpropylphenol polyoxyethylene ether, pull-apart powder, and sodium dodecylbenzene sulfonate.

5. The seed treatment suspension concentrate of prothioconazole·flufenamide·thiamethoxam according to claim 4, characterized in that, The wetting agent is sodium dioctyl sulfonate.

6. The seed treatment suspension concentrate of prothioconazole·flufenamide·thiamethoxam according to claim 1, characterized in that, The defoamer may be selected from one or more of the following: organosilicon compounds, modified polyethers, acetylacetonate, tributyl phosphate, butanol, C8-C10 fatty alcohols, and ester-ether compounds; the preservative may be selected from one or more of the following: benzisothiazolinone, sodium benzoate, formaldehyde, polyoxymethylene, sodium citrate, sodium salicylate, potassium sorbate, and Kathon; the film-forming agent may be selected from one or more of the following: polyvinyl alcohol, modified carboxypropyl cellulose, polyethylene glycol, rosin, styrene-acrylic emulsion, acrylic resin polymer, gelatin, and sodium alginate; the warning color may be selected from one or more of the following: Acid Red, Basic Blue, Basic Yellow G, and curcumin.

7. A method for preparing a seed treatment suspension of prothioconazole·flufenamide·thiamethoxam according to any one of claims 1-6, characterized in that, The steps are as follows: (1) Under shearing conditions, wetting agent, dispersant and defoamer are added to deionized water, shearing is continued, and prothioconazole, fluamide and thiamethoxam are added, and shearing is continued; (2) First, add xanthan gum to antifreeze ethylene glycol and stir to disperse it to form a dispersion. Then, add it together with preservative and another thickener, magnesium aluminum silicate, to the mixture obtained in step (1) and continue to shear to obtain a suspension slurry. (3) Under cooling conditions, the suspension slurry obtained in step (2) is stirred evenly and the temperature is controlled for three-stage sand milling; (4) Transfer the product obtained in step (3) to a mixing tank, add film-forming agent and warning color, cut evenly and send for inspection. If it passes inspection, it will be packaged. If it fails inspection, further adjustments will be made and it will be sent for inspection again until it passes inspection and is packaged.

8. The method for preparing a seed treatment suspension of prothioconazole·flufenamide·thiamethoxam according to claim 7, characterized in that, The grinding process in step (3) requires the cooling device to be turned on, and the temperature of the first-stage grinding should not exceed 30°C, and the temperature of the second and third-stage grinding should not exceed 35°C.

9. The application of a seed treatment suspension of prothioconazole·flufenamide·thiamethoxam according to any one of claims 1-6 or a seed treatment suspension of prothioconazole·flufenamide·thiamethoxam prepared by the preparation method according to any one of claims 7-8 in the control of agricultural pests and diseases, characterized in that, The pests and diseases mentioned include wheat root rot and wheat aphids.

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