Traditional Chinese medicine composition for treating toothache and preparation method thereof

Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating toothache and a preparation method thereof. The traditional Chinese medicine composition for treating toothache is prepared from the following raw materials in parts by weight: 3 to 4 parts of radix angelicae sinensis, 3 to 4 parts of radix rehmanniae recen, 5 to 7 parts of rhizoma cimicifugae, 2 to 4 parts of cortex moutan, 2 to 4 parts of gypsum and 4 to 5 parts of rhizoma coptidis from Sichuan of China. The traditional Chinese medicine composition for treating toothache is scientific and reasonable in compatibility, can perform targeted pain relieving treatment on different parts of teeth, can stabilize the teeth and promote secondary growth of the teeth, and solves the problems of non-fine treatment and single effect in the prior art. The preparation method of the traditional Chinese medicine composition for treating toothache is simple and easy to control, and large-scale production is facilitated.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine, specifically relating to a traditional Chinese medicine composition for treating toothache and its preparation method. Background Technology

[0002] Toothache is a common ailment. Symptoms include red and swollen gums, pain upon exposure to hot or cold stimuli, and swelling of the cheek. Toothache is mostly caused by gingivitis and periodontitis, dental caries (cavities), or cracked teeth leading to infection of the dental pulp (dental nerve). Traditional Chinese medicine believes that toothache is caused by external wind-evil, excessive stomach fire, kidney deficiency with excessive fire, and tooth decay due to worms.

[0003] Patent publication number CN101274024A discloses a pharmaceutical composition for treating toothache, which is prepared from the following raw material components in the following weight ratio: ephedra 1-2: rhubarb 1-3: angelica 1-4. This formulation has a limited number of raw material components, resulting in a overly singular efficacy; furthermore, this formulation lacks detailed research on the appropriate treatment methods for toothache in different locations.

[0004] Therefore, based on this, the technical solution of the present invention is proposed. Summary of the Invention

[0005] To address the problems existing in the prior art, the present invention provides a traditional Chinese medicine composition for treating toothache, comprising the following raw materials in parts by weight: 3-4 parts Angelica sinensis, 3-4 parts Rehmannia glutinosa, 5-7 parts Cimicifuga foetida, 2-4 parts Paeonia suffruticosa, 2-4 parts Gypsum fibrosum, and 4-5 parts Coptis chinensis. More preferably, the composition comprises 5 parts Angelica sinensis, 4 parts Rehmannia glutinosa, 6 parts Cimicifuga foetida, 3 parts Paeonia suffruticosa, 3 parts Gypsum fibrosum, and 4.5 parts Coptis chinensis.

[0006] Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: Angelica sinensis 3-4 parts, Rehmannia glutinosa 3-4 parts, Cimicifuga foetida 5-7 parts, Paeonia suffruticosa 2-4 parts, Gypsum fibrosum 2-4 parts, Coptis chinensis 4-5 parts, Anemarrhena asphodeloides 3-4 parts, Phellodendron chinense 4-5 parts (used to treat pain in the four upper incisors). A more preferred formulation: Angelica sinensis 5 parts, Rehmannia glutinosa 4 parts, Cimicifuga foetida 6 parts, Paeonia suffruticosa 3 parts, Gypsum fibrosum 3 parts, Coptis chinensis 4.5 parts, Anemarrhena asphodeloides 3.5 parts, Phellodendron chinense 4.4 parts.

[0007] Alternatively, use 3-4 parts Angelica sinensis, 3-4 parts Rehmannia glutinosa, 5-7 parts Cimicifuga foetida, 2-4 parts Paeonia suffruticosa, 2-4 parts Gypsum fibrosum, 4-5 parts Coptis chinensis, and 3-5 parts Ophiopogon japonicus (for treating lower incisor pain). A more preferred combination is 5 parts Angelica sinensis, 4 parts Rehmannia glutinosa, 6 parts Cimicifuga foetida, 3 parts Paeonia suffruticosa, 3 parts Gypsum fibrosum, 4.5 parts Coptis chinensis, and 4 parts Ophiopogon japonicus.

[0008] Alternatively, use 3-4 parts Angelica sinensis, 3-4 parts Rehmannia glutinosa, 5-7 parts Cimicifuga foetida, 2-4 parts Paeonia suffruticosa, 2-4 parts Gypsum fibrosum, 4-5 parts Coptis chinensis, 4-5 parts Gardenia jasminoides, and 4-6 parts Bupleurum chinense (for treating pain in the upper left molar). A more preferred combination is 5 parts Angelica sinensis, 4 parts Rehmannia glutinosa, 6 parts Cimicifuga foetida, 3 parts Paeonia suffruticosa, 3 parts Gypsum fibrosum, 4.5 parts Coptis chinensis, 4.5 parts Gardenia jasminoides, and 5 parts Bupleurum chinense.

[0009] Alternatively, use 3-4 parts Angelica sinensis, 3-4 parts Rehmannia glutinosa, 5-7 parts Cimicifuga foetida, 2-4 parts Paeonia suffruticosa, 2-4 parts Gypsum fibrosum, 4-5 parts Coptis chinensis, and 5-7 parts Glycyrrhiza uralensis (for treating pain in the lower left molar). A more preferred combination is 5 parts Angelica sinensis, 4 parts Rehmannia glutinosa, 6 parts Cimicifuga foetida, 3 parts Paeonia suffruticosa, 3 parts Gypsum fibrosum, 4.5 parts Coptis chinensis, and 6 parts Glycyrrhiza uralensis.

[0010] Alternatively, use 3-4 parts Angelica sinensis, 3-4 parts Rehmannia glutinosa, 5-7 parts Cimicifuga foetida, 2-4 parts Paeonia suffruticosa, 2-4 parts Gypsum fibrosum, 4-5 parts Coptis chinensis, 5-6 parts Scutellaria baicalensis, and 4-5 parts Platycodon grandiflorus (for treating pain in the upper right molar). A more preferred combination is 5 parts Angelica sinensis, 4 parts Rehmannia glutinosa, 6 parts Cimicifuga foetida, 3 parts Paeonia suffruticosa, 3 parts Gypsum fibrosum, 4.5 parts Coptis chinensis, 5.3 parts Scutellaria baicalensis, and 4.6 parts Platycodon grandiflorus.

[0011] Alternatively, use 3-4 parts Angelica sinensis, 3-4 parts Rehmannia glutinosa, 5-7 parts Cimicifuga foetida, 2-4 parts Paeonia suffruticosa, 2-4 parts Gypsum fibrosum, 4-5 parts Coptis chinensis, and 5-6 parts Rheum palmatum and Citrus aurantium (used to treat pain in the lower right molar). A more preferred combination is 5 parts Angelica sinensis, 4 parts Rehmannia glutinosa, 6 parts Cimicifuga foetida, 3 parts Paeonia suffruticosa, 3 parts Gypsum fibrosum, 4.5 parts Coptis chinensis, and 5.2 parts Rheum palmatum and Citrus aurantium.

[0012] Alternatively, use 3-4 parts Angelica sinensis, 3-4 parts Rehmannia glutinosa, 5-7 parts Cimicifuga foetida, 2-4 parts Paeonia suffruticosa, 2-4 parts Gypsum fibrosum, 4-5 parts Coptis chinensis, 4-5 parts Atractylodes macrocephala, and 3-4 parts Paeonia lactiflora (for treating pain in the upper left and right teeth, not molars). A more preferred formula is: 5 parts Angelica sinensis, 4 parts Rehmannia glutinosa, 6 parts Cimicifuga foetida, 3 parts Paeonia suffruticosa, 3 parts Gypsum fibrosum, 4.5 parts Coptis chinensis, 4.2 parts Atractylodes macrocephala, and 3.8 parts Paeonia lactiflora.

[0013] Alternatively, use 3-4 parts Angelica sinensis, 3-4 parts Rehmannia glutinosa, 5-7 parts Cimicifuga foetida, 2-4 parts Paeonia suffruticosa, 2-4 parts Gypsum, 4-5 parts Coptis chinensis, 4-5 parts Atractylodes macrocephala, and 4-5 parts Ligusticum chuanxiong (for treating lower left and right tooth pain, not molar pain). A more preferred combination is 5 parts Angelica sinensis, 4 parts Rehmannia glutinosa, 6 parts Cimicifuga foetida, 3 parts Paeonia suffruticosa, 3 parts Gypsum, 4.5 parts Coptis chinensis, 4.7 parts Atractylodes macrocephala, and 4.9 parts Ligusticum chuanxiong.

[0014] To facilitate a deeper understanding of this invention, the following explanations are provided regarding nerve conduction in toothache, pain regionalization, and the mechanism of action of the traditional Chinese medicine composition: (a) Nerve conduction of toothache: The nerve supply to teeth primarily comes from the trigeminal nerve, which acts as a sophisticated information network responsible for transmitting sensations throughout the face and mouth. When dental problems cause pain, the specific transmission pathway is as follows: Nerve endings in the dental pulp act as initial pain receptors. Once stimulated by harmful stimuli such as inflammation, physical damage, or chemical irritation, these nerve endings are activated, generating nerve impulses. These impulses are transmitted along the nerve fibers within the dental pulp, most of which are branches of the trigeminal nerve. Nerve impulses from maxillary teeth are transmitted to the central nervous system by branches of the maxillary nerve, while those from mandibular teeth are transmitted by branches of the mandibular nerve. For example, when tooth decay leads to pulpitis, inflammatory mediators such as prostaglandins and bradykinin stimulate the nerve endings in the dental pulp, increasing their sensitivity and generating more nerve impulses. These impulses are then transmitted upwards through branches of the trigeminal nerve.

[0015] From the perspective of Traditional Chinese Medicine (TCM), the upper and lower teeth belong to completely different meridians. The upper teeth are mainly connected to the Stomach Meridian of Foot Yangming, while the lower teeth belong to the Large Intestine Meridian of Hand Yangming. This difference stems from the pathways of the meridians: the Stomach Meridian starts beside the nose, descends around the lips, and then distributes to the upper gums; the Large Intestine Meridian starts from the tip of the index finger, ascends along the arm to the face, and then distributes to the lower gums. This meridian connection establishes a correspondence between the upper and lower teeth and different internal organs.

[0016] Pain in the upper left molar corresponds to the Gallbladder Meridian; pain in the lower left molar corresponds to the Liver Meridian; pain in the upper right molar corresponds to the Hand Yang Meridian; pain in the lower right molar corresponds to the Lung Meridian; pain in the upper left and right sides of the teeth corresponds to the Kidney Meridian; pain in the lower right and left sides of the teeth corresponds to the Spleen Meridian; pain in the four upper incisors corresponds to the Heart Meridian; and pain in the four lower incisors (with open teeth) corresponds to the Stomach Meridian. Different types of toothache correspond to different meridians. This treatment utilizes various combinations of herbs, including Angelica sinensis, Rehmannia glutinosa, Cimicifuga foetida, Paeonia suffruticosa, Gypsum fibrosum, Coptis chinensis, Anemarrhena asphodeloides, Phellodendron chinense, Ophiopogon japonicus, Gardenia jasminoides, Bupleurum chinense, Glycyrrhiza uralensis, Scutellaria baicalensis, Platycodon grandiflorus, Rheum palmatum, Citrus aurantium, Atractylodes macrocephala, Paeonia lactiflora, and Ligusticum chuanxiong, to treat toothache in different locations. Its targeted therapy principle is to regulate and treat different meridians to achieve the desired effect.

[0017] (II) Division of Pain Areas: In conventional understanding in this field, the nerve control areas of teeth are usually roughly distinguished by the maxillary and mandibular nerves. However, this invention further subdivides the pain areas of teeth into the upper incisors, lower incisors, upper left molar, lower left molar, upper right molar, lower right molar, upper left and right lateral teeth, and lower left and right lateral teeth. This is the core of this invention.

[0018] From a microscopic perspective of nerve distribution, although the maxillary and mandibular nerves respectively control sensation in the maxilla and mandible teeth, even within the maxilla or mandible, the density of nerve endings, the direction of nerve fibers, and the connections with branches of the trigeminal nerve vary between teeth in different locations. For example, the nerve endings in the upper incisor region are relatively dense, and the nerve fibers there have a closer connection with specific subbranches within the maxillary branch of the trigeminal nerve during upward transmission; while the nerve conduction pathway in the lower incisors differs from that in the upper incisors in certain subtle structures. These subtle differences in nerve distribution result in variations in the characteristics and intensity of signal transmission when teeth in different locations experience pain.

[0019] (III) Mechanism of Action of Traditional Chinese Medicine Combinations: This invention involves replacing individual raw material components to form a traditional Chinese medicine composition for treating toothache in different areas (see examples below). Its core lies in utilizing the unique pharmacological properties of various medicinal materials in traditional Chinese medicine to achieve targeted treatment of toothache in specific areas. Each replacement drug is carefully selected to match the physiological and pathological characteristics and nerve conduction features of the teeth in that specific area, thereby achieving the best therapeutic effect.

[0020] Based on the same technical concept, the present invention further provides a method for preparing a traditional Chinese medicine composition for treating toothache, the preparation method comprising the following steps: (1) After washing and drying all raw materials, clean raw materials are obtained; (2) The clean raw material is mixed with water and boiled. After the boiling is completed, it is filtered to obtain the first filtrate and the filter residue. (3) The filter residue is mixed with water again and boiled. After the process is completed, it is filtered to obtain the second filtrate. (4) Combine the first filtrate and the second filtrate to obtain the decoction; (5) Concentrate the decoction to obtain concentrated decoction, thus completing the preparation.

[0021] Preferably, in step (2), the weight ratio of the clean raw material to water is 1:3~4; and the decocting time is 30~40 minutes.

[0022] Preferably, in step (3), the weight ratio of the filter residue to water is 1:4~5; and the decocting time is 40~50 min.

[0023] Preferably, in step (5), the volume of the concentrated decoction is reduced to 1 / 2 to 2 / 3 of the original volume.

[0024] Based on the same technical concept, the present invention provides a method for preparing a traditional Chinese medicine composition for treating toothache, the preparation method comprising the following steps: (i) After crushing all raw materials, dry them to obtain raw material powder; (ii) Heat the honey to remove moisture, stirring constantly to prevent burning, to obtain refined honey; (iii) The raw material powder is mixed with the refined honey and stirred. The mixture is first made into strips and then into pills to obtain honey pills, thus completing the preparation.

[0025] Preferably, in step (i), the raw material powder is passed through an 80-100 mesh sieve.

[0026] Preferably, in step (iii), the weight ratio of the raw material powder to the refined honey is 1:1 to 1.5.

[0027] The beneficial effects of this invention are as follows: 1. The traditional Chinese medicine composition for treating toothache described in this invention is scientifically and rationally formulated, and can provide targeted pain relief for different parts of the tooth. It can stabilize the tooth, promote the secondary growth of the tooth, and solve the problems of imprecise treatment and single effect in the prior art.

[0028] 2. The preparation method of the traditional Chinese medicine composition for treating toothache described in this invention is simple and easy to control, which is conducive to large-scale production. Detailed Implementation

[0029] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be described in detail below. Obviously, the described embodiments are merely some embodiments of this invention, and not all embodiments. Based on the embodiments of this invention, all other implementation methods obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0030] Example 1 This embodiment provides a method for preparing a traditional Chinese medicine composition for treating pain in the four upper incisors (related to the Heart Meridian), the preparation method comprising the following steps: (1) Wash and dry 5g of Angelica sinensis, 4g of Rehmannia glutinosa, 6g of Cimicifuga foetida, 3g of Paeonia suffruticosa, 3g of Gypsum fibrosum, 4.5g of Coptis chinensis, 3.5g of Anemarrhena asphodeloides, and 4.4g of Phellodendron chinense to obtain the clean raw materials; (2) The clean raw material is mixed with water at a ratio of 1:3 and boiled for 30 minutes. After the mixture is boiled, it is filtered to obtain the first filtrate and the filter residue. (3) The filter residue is mixed with water at a ratio of 1:4 and boiled for 40 minutes. After the mixture is boiled, it is filtered to obtain the second filtrate. (4) Combine the first filtrate and the second filtrate to obtain the decoction; (5) Concentrate the decoction to 1 / 2 of its original volume to obtain concentrated decoction, thus completing the preparation.

[0031] In this embodiment, the basic formula functions as follows: Angelica sinensis is sweet and pungent in taste and warm in nature, and enters the liver, heart, and spleen meridians. It can nourish and invigorate blood, improve blood circulation in the area along the heart meridian (the four upper incisors), and relieve pain caused by blood heat and stagnation. Rehmannia glutinosa is cold in nature and enters the heart, liver, and kidney meridians. It can clear heat and cool the blood, and is effective for pulpitis and gingival swelling caused by excessive heat in the heart meridian. Cimicifuga foetida is slightly cold in nature and enters the lung, spleen, and stomach meridians. It can clear heat and detoxify, and guide the other herbs to the oral cavity, targeting the upper incisors. Paeonia suffruticosa is slightly cold in nature and enters the heart, liver, and kidney meridians. It cools the blood and invigorates blood, assisting Rehmannia glutinosa in clearing heat stagnation in the heart meridian and reducing inflammatory reactions. Gypsum is cold in nature and enters the lung and stomach meridians. It can clear stomach fire (which easily disturbs the heart meridian) and prevent the transmission of heat evil. Coptis chinensis is cold in nature and enters the heart, liver, and stomach meridians. It directly clears excess fire in the heart meridian and relieves symptoms such as burning pain in the teeth caused by heart fire and aggravation by heat stimulation.

[0032] The newly added formula has the following effects: Anemarrhena asphodeloides is cold in nature and enters the lung, stomach and kidney meridians. It can clear heat and purge fire, nourish yin and moisten dryness, assist Coptis chinensis in clearing fire evil in the heart meridian, and at the same time prevent bitter and cold drugs from damaging the yin fluid of the heart meridian; Phellodendron chinense is cold in nature and enters the kidney and bladder meridians. It can guide the residual heat of the heart meridian downward and excrete it through the metabolism of the kidney meridian, so as to avoid the heat evil from lingering in the upper incisor area along the heart meridian.

[0033] The synergistic mechanism is as follows: The whole formula takes "clearing the heart and cooling the blood, and guiding the heat downward" as its core. The basic formula clears the excess fire in the heart meridian and improves the local qi and blood. Anemarrhena asphodeloides and Phellodendron chinense assist in clearing heat and nourishing yin, and guiding the heat outward. It precisely targets the four upper incisors along the heart meridian, relieving pain and swelling caused by the upward flaring of heart fire, while repairing thermal damage to the dental pulp and gums.

[0034] Example 2 This embodiment provides a method for preparing a traditional Chinese medicine composition for treating lower incisor pain (related to the Stomach Meridian), the preparation method comprising the following steps: (1) Wash and dry 5g of Angelica sinensis, 4g of Rehmannia glutinosa, 6g of Cimicifuga foetida, 3g of Paeonia suffruticosa, 3g of Gypsum fibrosum, 4.5g of Coptis chinensis and 4g of Ophiopogon japonicus to obtain the clean raw materials; (2) The clean raw material is mixed with water at a ratio of 1:4 and boiled for 40 minutes. After the mixture is boiled, it is filtered to obtain the first filtrate and the filter residue. (3) Mix the filter residue with water at a ratio of 1:5 and boil for 50 minutes. After completion, filter to obtain the second filtrate. (4) Combine the first filtrate and the second filtrate to obtain the decoction; (5) Concentrate the decoction to 2 / 3 of its original volume to obtain concentrated decoction, thus completing the preparation.

[0035] In this embodiment, the basic formula functions as follows: Angelica sinensis nourishes and invigorates blood, improving blood stasis in the lower incisor area along the stomach meridian and promoting gum tissue repair; Rehmannia glutinosa cools blood and nourishes yin, addressing gum dryness and toothache caused by excessive heat in the stomach meridian damaging yin; Cimicifuga foetida guides the medicine upward to the oral cavity, while clearing away heat stagnation in the stomach meridian; Paeonia suffruticosa cools blood and invigorates blood, reducing gum redness and swelling caused by stomach heat stagnation; Gypsum is cold in nature and enters the stomach meridian, directly clearing away excess heat in the stomach meridian and relieving severe pain in the lower incisors and pain upon exposure to heat caused by excessive stomach fire; Coptis chinensis clears stomach heat and assists Gypsum in enhancing its heat-clearing and pain-relieving effects.

[0036] The new formula has the following effects: Ophiopogon japonicus is sweet and slightly bitter, and slightly cold in nature. It enters the heart and stomach meridians. It can nourish yin and generate fluids, replenish the fluids consumed by excessive heat in the stomach meridian, and relieve dryness and pain in the lower front teeth. It can also assist Rehmannia glutinosa in nourishing yin and prevent stomach heat from damaging yin, which can lead to recurrent pain.

[0037] The synergistic mechanism is as follows: the whole formula revolves around "clearing stomach heat and nourishing yin, relieving pain and protecting gums". The basic formula clears away excess heat in the stomach meridian and improves local circulation. Ophiopogon japonicus replenishes stomach yin. It is effective for lower incisor pain caused by excessive heat in the stomach meridian that damages yin (such as pulp infection caused by tooth decay and pain caused by gingival recession), achieving the effect of "clearing heat without damaging yin, relieving pain and protecting gums".

[0038] Example 3 This embodiment provides a method for preparing a traditional Chinese medicine composition for treating upper left molar pain (related to the gallbladder meridian), the preparation method comprising the following steps: (i) 5g of Angelica sinensis, 4g of Rehmannia glutinosa, 6g of Cimicifuga foetida, 3g of Paeonia suffruticosa, 3g of Gypsum fibrosum, 4.5g of Coptis chinensis, 4.5g of Gardenia jasminoides, and 5g of Bupleurum chinense were pulverized, dried, and passed through an 80-mesh sieve to obtain raw material powder. (ii) Heat the honey to remove moisture, stirring constantly to prevent burning, to obtain refined honey; (iii) The raw material powder and the refined honey are mixed at a weight ratio of 1:1 and stirred. The mixture is first made into strips and then into pills to obtain honey pills, thus completing the preparation.

[0039] In this embodiment, the basic formula functions as follows: Angelica sinensis nourishes and invigorates blood circulation, improving blood and qi circulation in the upper left molar area along the gallbladder meridian, and relieving pain caused by heat stagnation in the gallbladder meridian; Rehmannia glutinosa cools and clears heat, targeting pulpitis and facial swelling caused by excessive heat in the gallbladder meridian; Cimicifuga foetida guides the medicine upwards to the left side of the oral cavity, targeting the upper left molar; Paeonia suffruticosa cools and invigorates blood circulation, assisting in clearing heat stagnation in the gallbladder meridian; Gypsum clears and drains stomach fire (gallbladder fire easily attacks the stomach), preventing stomach fire and gallbladder fire from overlapping and aggravating the pain; Coptis chinensis clears and drains gallbladder fire (Coptis chinensis enters the liver meridian, and the liver and gallbladder are internally and externally related), relieving radiating pain in the upper left molar caused by gallbladder fire.

[0040] The new formula works as follows: Gardenia is cold in nature and enters the Triple Burner Meridian. It can clear away excess heat in the Gallbladder Meridian and expel heat evil through metabolism in the Triple Burner Meridian, thus relieving burning pain in the upper left molar. Bupleurum is slightly cold in nature and enters the Liver and Gallbladder Meridians. It can soothe the liver and relieve depression (stagnation in the Gallbladder Meridian easily generates heat), and guide the medicine into the Gallbladder Meridian, enhancing the overall targeting of the formula to the Gallbladder Meridian area, while relieving referred pain in the temporal region caused by gallbladder fire.

[0041] The synergistic mechanism is as follows: The whole formula takes "clearing heat and purging fire, unblocking the meridians and relieving pain" as its core. The basic formula clears heat and purges evil in the gallbladder meridian and improves local qi and blood. Gardenia and Bupleurum enhance the effect of clearing heat and unblocking the meridians. For pain in the upper left molar caused by excessive heat in the gallbladder meridian (such as pain caused by periodontitis or pericoronitis of wisdom teeth), it achieves the effect of "clearing heat and unblocking the meridians, relieving pain and relieving radiating pain".

[0042] Example 4 This embodiment provides a method for preparing a traditional Chinese medicine composition for treating lower left molar pain (related to the liver meridian), the preparation method comprising the following steps: (i) 5g of Angelica sinensis, 4g of Rehmannia glutinosa, 6g of Cimicifuga foetida, 3g of Paeonia suffruticosa, 3g of Gypsum fibrosum, 4.5g of Coptis chinensis and 6g of Glycyrrhiza uralensis were pulverized, dried, and passed through a 100-mesh sieve to obtain raw material powder; (ii) Heat the honey to remove moisture, stirring constantly to prevent burning, to obtain refined honey; (iii) The raw material powder and the refined honey are mixed at a weight ratio of 1:1.5 and stirred. The mixture is first made into strips and then into pills to obtain honey pills, thus completing the preparation.

[0043] In this embodiment, the basic formula functions as follows: Angelica sinensis nourishes blood to replenish the deficiency of Yin and blood in the liver meridian, and also invigorates blood circulation and unblocks collaterals, improving the stagnation of Qi and blood in the lower left molar area along the liver meridian, relieving tooth pain caused by liver meridian heat stagnation or blood deficiency; Rehmannia glutinosa clears heat from the liver meridian, targeting pulpitis, gingival redness and burning caused by excessive heat in the liver meridian, while nourishing Yin and generating fluids to prevent heat from consuming the Yin fluids of the liver meridian; Cimicifuga foetida's "guiding the medicine upward" property directs the efficacy of the entire formula directly to the lower left side of the oral cavity, precisely acting on the lower left molar, while also possessing... It has the effects of clearing heat and detoxifying, and helps to clear the stagnation of heat in the liver meridian; Moutan bark can cool the blood and promote blood circulation, and clear liver fire, which can not only relieve the gum swelling caused by blood heat in the liver meridian, but also dredge the qi and blood of the liver meridian and reduce the pain caused by stagnation; Gypsum can clear stomach fire (in traditional Chinese medicine theory, "liver wood easily overcomes spleen earth", and excessive liver fire often leads to stomach fire rising), and avoid the stomach fire and liver fire overlapping, which can aggravate the pain of the lower left molar; Coptis can directly purge the excess fire in the liver meridian, and quickly suppress the rampant fire evil for symptoms such as severe pain in the lower left molar caused by excessive liver fire and pain aggravated by heat stimulation.

[0044] The new formula has the following effects: Licorice is sweet and neutral in nature, and enters the spleen and stomach meridians. It can strengthen the spleen and replenish qi (spleen qi deficiency easily generates dampness), enhance the spleen meridian's function of transportation and transformation, reduce the generation of damp heat from the root, relieve pain and directly alleviate the spasmodic pain of the lower left molar, and at the same time harmonize the bitter and cold drugs in the formula to avoid damaging the spleen yang.

[0045] The synergistic mechanism is as follows: the whole formula revolves around "clearing the spleen and removing dampness, replenishing qi and relieving pain". The basic formula clears damp heat in the spleen meridian and improves local circulation. Licorice strengthens the spleen and replenishes qi, relieves pain and relieves spasms. It is aimed at lower left molar pain caused by damp heat in the spleen meridian (such as pain caused by gingivitis and periodontitis), and achieves the effect of "clearing heat and removing dampness without damaging the spleen, relieving pain and strengthening the spleen".

[0046] Example 5 This embodiment provides a method for preparing a traditional Chinese medicine composition for treating upper right molar pain (belonging to the Hand Yang Meridian), the preparation method comprising the following steps: (i) 5g of Angelica sinensis, 4g of Rehmannia glutinosa, 6g of Cimicifuga foetida, 3g of Paeonia suffruticosa, 3g of Gypsum fibrosum, 4.5g of Coptis chinensis, 5.3g of Scutellaria baicalensis, and 4.6g of Platycodon grandiflorus were pulverized, dried, and passed through a 90-mesh sieve to obtain raw material powder; (ii) Heat the honey to remove moisture, stirring constantly to prevent burning, to obtain refined honey; (iii) The raw material powder and the refined honey are mixed at a weight ratio of 1:1.5 and stirred. The mixture is first made into strips and then into pills to obtain honey pills, thus completing the preparation.

[0047] In this embodiment, the basic formula functions as follows: Angelica sinensis nourishes and invigorates blood circulation, improving blood and qi circulation in the upper right molar area along the hand yang meridians (such as the hand shaoyang sanjiao meridian and the hand yangming large intestine meridian), relieving pain caused by meridian stagnation; Rehmannia glutinosa cools blood and clears heat, targeting pulpitis and gingival redness and swelling caused by excessive heat in the hand yang meridians; Cimicifuga foetida guides the medicine upward to the upper right side of the oral cavity, targeting the upper right molar; Paeonia suffruticosa cools blood and invigorates blood circulation, assisting in clearing heat stagnation in the hand yang meridians; Gypsum fibrosum clears stomach fire (the hand yang meridian and the stomach meridian are connected), preventing the transmission of heat evil; Coptis chinensis clears excess fire in the hand yang meridians, relieving severe pain in the upper right molar caused by excessive heat in the hand yang meridians, which worsens with heat stimulation.

[0048] The newly added formula works as follows: Scutellaria baicalensis is cold in nature and enters the lung and gallbladder meridians. It can clear away heat evil in the hand yang meridian (the hand shaoyang meridian is connected to the lung) and relieve the burning pain of the upper right molar. Platycodon grandiflorus is neutral in nature and enters the lung meridian. It can not only promote lung function and eliminate phlegm (excessive heat in the hand yang meridian easily produces phlegm), but also carry the medicine upward to the upper right molar area where the hand yang meridian runs, enhancing the targeting of the whole formula, and at the same time relieving gum swelling and pain caused by phlegm and heat obstruction.

[0049] The synergistic mechanism is as follows: The whole formula takes "clearing heat in the hand yang meridian, resolving phlegm, unblocking the meridian and relieving pain" as its core. The basic formula clears heat in the hand yang meridian and improves local circulation. Scutellaria baicalensis and Platycodon grandiflorus enhance the effects of clearing heat and resolving phlegm and carrying drugs to target the target. It is used for pain in the upper right molar caused by excessive heat in the hand yang meridian (such as pain caused by tooth decay or pulpitis) to achieve the effect of "clearing heat and resolving phlegm, unblocking the meridian and relieving pain".

[0050] Example 6 This embodiment provides a method for preparing a traditional Chinese medicine composition for treating lower right molar pain (related to the lung meridian), the preparation method comprising the following steps: (i) 5g of Angelica sinensis, 4g of Rehmannia glutinosa, 6g of Cimicifuga foetida, 3g of Paeonia suffruticosa, 3g of Gypsum fibrosum, 4.5g of Coptis chinensis, and 5.2g of Rheum palmatum and Citrus aurantium are pulverized, dried, and passed through an 80-mesh sieve to obtain raw material powder; (ii) Heat the honey to remove moisture, stirring constantly to prevent burning, to obtain refined honey; (iii) The raw material powder and the refined honey are mixed at a weight ratio of 1:1.2 and stirred. The mixture is first made into strips and then into pills to obtain honey pills, thus completing the preparation.

[0051] In this embodiment, the basic formula functions as follows: Angelica sinensis nourishes and invigorates blood, improving blood stasis in the lower right molar area along the lung meridian and promoting gum tissue repair; Rehmannia glutinosa cools blood and nourishes yin, addressing gum dryness and pain caused by excessive heat in the lung meridian damaging yin; Cimicifuga foetida guides the medicine upwards to the lower right side of the mouth, while clearing away stagnant heat in the lung meridian; Paeonia suffruticosa cools blood and invigorates blood, reducing gum redness and swelling caused by heat stasis in the lung meridian; Gypsum clears away stomach fire (the lung and stomach are internally and externally related, and stomach fire easily attacks the lung), preventing the accumulation of heat evil; Coptis chinensis clears away excess fire in the lung meridian, relieving pain in the lower right molar and throat discomfort caused by lung fire rising upwards.

[0052] The new formula works as follows: Rhubarb and Citrus aurantium are in the form of rhubarb, which is cold in nature and enters the large intestine meridian. It can purge and relieve constipation, and guide the residual heat of the lung meridian out of the large intestine, so as to avoid the heat evil from lingering in the lower right molar area where the lung meridian runs. Citrus aurantium is slightly cold in nature and enters the spleen and lung meridians. It can regulate qi and relieve chest tightness, improve the stagnation of qi in the lung meridian, assist rhubarb in enhancing the effect of guiding stagnation and purging heat, and at the same time relieve the swelling and pain of the lower right molar caused by qi stagnation.

[0053] The synergistic mechanism is as follows: the whole formula revolves around "clearing lung heat and relieving pain by promoting circulation". The basic formula clears lung heat and improves local circulation, while rhubarb and immature bitter orange promote circulation, clear heat and relieve pain by promoting circulation. It is effective for lower right molar pain caused by excessive heat in the lung meridian (such as pain caused by periodontitis or gingival abscess). It achieves the effect of "clearing heat, promoting circulation, relieving pain and swelling".

[0054] Example 7 This embodiment provides a method for preparing a traditional Chinese medicine composition for treating upper left and right toothache (not molar, but related to the kidney meridian), the preparation method comprising the following steps: (i) 5g of Angelica sinensis, 4g of Rehmannia glutinosa, 6g of Cimicifuga foetida, 3g of Paeonia suffruticosa, 3g of Gypsum fibrosum, 4.5g of Coptis chinensis, 4.2g of Atractylodes macrocephala, and 3.8g of Paeonia lactiflora are pulverized, dried, and passed through an 80-mesh sieve to obtain raw material powder; (ii) Heat the honey to remove moisture, stirring constantly to prevent burning, to obtain refined honey; (iii) The raw material powder and the refined honey are mixed at a weight ratio of 1:1.3 and stirred. The mixture is first made into strips and then into pills to obtain honey pills, thus completing the preparation.

[0055] In this embodiment, the basic formula functions as follows: Angelica sinensis nourishes and invigorates blood circulation, improving blood and qi circulation in the upper left and right teeth areas along the kidney meridian, and relieving pain caused by kidney meridian stagnation and heat; Rehmannia glutinosa cools blood and nourishes yin, targeting gingival swelling and toothache caused by kidney meridian yin deficiency and fire excess; Cimicifuga foetida guides the medicine upward to the upper side of the mouth, targeting the upper left and right teeth; Paeonia suffruticosa cools blood and invigorates blood circulation, assisting in clearing kidney meridian stagnation and heat; Gypsum clears stomach fire (the kidney and stomach are connected, and stomach fire easily attacks the kidney), preventing the accumulation of heat evil; Coptis chinensis clears kidney meridian deficiency fire (Coptis chinensis enters the heart meridian, and the heart and kidneys interact, which can indirectly clear kidney fire), relieving pain in the upper left and right teeth caused by kidney fire rising upward.

[0056] The new formula has the following effects: Atractylodes macrocephala is warm in nature and enters the spleen and stomach meridians. It can strengthen the spleen and replenish qi (the spleen is the foundation of acquired constitution and can nourish the kidneys), enhance the generation of yin fluid in the kidney meridian, and relieve kidney yin deficiency from the root. Paeonia lactiflora is slightly cold in nature and enters the liver and spleen meridians. It can nourish blood and soften the liver (the liver and kidneys are of the same origin), assist Rehmannia glutinosa in enhancing the yin-nourishing effect, and at the same time relieve spasmodic pain, directly relieving the spasmodic pain of the upper left and right teeth.

[0057] The synergistic mechanism is as follows: The whole formula takes "nourishing yin and tonifying the kidney, clearing heat and relieving pain" as its core. The basic formula clears away the deficiency fire of the kidney meridian and improves local circulation. Atractylodes macrocephala and Paeonia lactiflora strengthen the spleen and nourish blood, nourish yin and relieve spasms. It is aimed at the pain of the upper left and right teeth caused by yin deficiency and fire in the kidney meridian (such as pain caused by gum recession and exposed tooth roots), and achieves the effect of "nourishing yin and clearing heat, relieving pain and protecting the kidney".

[0058] Example 8 This embodiment provides a method for preparing a traditional Chinese medicine composition for treating lower left and right toothache (not molars, but related to the spleen meridian), the preparation method comprising the following steps: (i) 5g of Angelica sinensis, 4g of Rehmannia glutinosa, 6g of Cimicifuga foetida, 3g of Paeonia suffruticosa, 3g of Gypsum fibrosum, 4.5g of Coptis chinensis, 4.7g of Atractylodes macrocephala, and 4.9g of Ligusticum chuanxiong are pulverized, dried, and passed through an 80-mesh sieve to obtain raw material powder; (ii) Heat the honey to remove moisture, stirring constantly to prevent burning, to obtain refined honey; (iii) The raw material powder and the refined honey are mixed at a weight ratio of 1:1.5 and stirred. The mixture is first made into strips and then into pills to obtain honey pills, thus completing the preparation.

[0059] In this embodiment, the basic formula functions as follows: Angelica sinensis nourishes and invigorates blood, improving blood stasis in the lower left and right tooth areas along the spleen meridian and promoting gum repair; Rehmannia glutinosa cools blood and nourishes yin, addressing gum redness, swelling, and pain caused by damp-heat damaging yin in the spleen meridian; Cimicifuga foetida guides the medicine upwards to the lower side of the mouth, while clearing heat stagnation in the spleen meridian; Paeonia suffruticosa cools blood and invigorates blood, reducing inflammation caused by damp-heat stagnation in the spleen meridian; Gypsum fibrosum clears stomach fire (the spleen and stomach are internally and externally related, and stomach fire easily attacks the spleen), preventing the accumulation of damp-heat; Coptis chinensis clears damp-heat in the spleen meridian, relieving swelling and pain in the lower left and right teeth caused by damp-heat in the spleen meridian.

[0060] The new formula has the following effects: Atractylodes macrocephala is warm in nature and enters the spleen and stomach meridians. It can strengthen the spleen and replenish qi, dry dampness and promote diuresis, enhance the spleen meridian's function of transportation and transformation, reduce the generation of damp heat from the root, and repair the damage to the gum tissue caused by spleen meridian weakness; Ligusticum chuanxiong is warm in nature and enters the liver and spleen meridians. It can invigorate blood and promote qi circulation, dispel wind and relieve pain, enhance the blood-activating effect of Angelica sinensis and Paeonia suffruticosa, improve the blood circulation of the lower left and right teeth areas, and relieve pain caused by qi stagnation and blood stasis.

[0061] The synergistic mechanism is as follows: the whole formula revolves around "strengthening the spleen and removing dampness, promoting blood circulation and relieving pain". The basic formula clears damp heat in the spleen meridian and improves local circulation. Atractylodes macrocephala and Ligusticum chuanxiong strengthen the spleen, dry dampness, promote blood circulation and regulate qi. It is aimed at the lower left and right tooth pain caused by damp heat stagnation in the spleen meridian (such as pain caused by gingivitis and periodontitis), and achieves the effect of "removing dampness, promoting blood circulation, relieving pain and strengthening the spleen".

[0062] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention should be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A traditional Chinese medicine composition for treating toothache, characterized in that, The ingredients include the following parts by weight: Angelica sinensis 3-4 parts, Rehmannia glutinosa 3-4 parts, Cimicifuga foetida 5-7 parts, Paeonia suffruticosa 2-4 parts, Gypsum 2-4 parts, and Coptis chinensis 4-5 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The ingredients include the following parts by weight: Angelica sinensis 3-4 parts, Rehmannia glutinosa 3-4 parts, Cimicifuga foetida 5-7 parts, Paeonia suffruticosa 2-4 parts, Gypsum 2-4 parts, Coptis chinensis 4-5 parts, Anemarrhena asphodeloides 3-4 parts, Phellodendron chinense 4-5 parts; Alternatively, use 3-4 parts Angelica sinensis, 3-4 parts Rehmannia glutinosa, 5-7 parts Cimicifuga foetida, 2-4 parts Paeonia suffruticosa, 2-4 parts Gypsum fibrosum, 4-5 parts Coptis chinensis, and 3-5 parts Ophiopogon japonicus. Alternatively, use 3-4 parts Angelica sinensis, 3-4 parts Rehmannia glutinosa, 5-7 parts Cimicifuga foetida, 2-4 parts Paeonia suffruticosa, 2-4 parts Gypsum fibrosum, 4-5 parts Coptis chinensis, 4-5 parts Gardenia jasminoides, and 4-6 parts Bupleurum chinense; Alternatively, use 3-4 parts Angelica sinensis, 3-4 parts Rehmannia glutinosa, 5-7 parts Cimicifuga foetida, 2-4 parts Paeonia suffruticosa, 2-4 parts Gypsum fibrosum, 4-5 parts Coptis chinensis, and 5-7 parts Glycyrrhiza uralensis. Alternatively, use 3-4 parts Angelica sinensis, 3-4 parts Rehmannia glutinosa, 5-7 parts Cimicifuga foetida, 2-4 parts Paeonia suffruticosa, 2-4 parts Gypsum fibrosum, 4-5 parts Coptis chinensis, 5-6 parts Scutellaria baicalensis, and 4-5 parts Platycodon grandiflorus. Alternatively, use 3-4 parts Angelica sinensis, 3-4 parts Rehmannia glutinosa, 5-7 parts Cimicifuga foetida, 2-4 parts Paeonia suffruticosa, 2-4 parts Gypsum fibrosum, 4-5 parts Coptis chinensis, and 5-6 parts Rheum palmatum and Citrus aurantium. Alternatively, use 3-4 parts Angelica sinensis, 3-4 parts Rehmannia glutinosa, 5-7 parts Cimicifuga foetida, 2-4 parts Paeonia suffruticosa, 2-4 parts Gypsum fibrosum, 4-5 parts Coptis chinensis, 4-5 parts Atractylodes macrocephala, and 3-4 parts Paeonia lactiflora. Alternatively, use 3-4 parts Angelica sinensis, 3-4 parts Rehmannia glutinosa, 5-7 parts Cimicifuga foetida, 2-4 parts Paeonia suffruticosa, 2-4 parts Gypsum fibrosum, 4-5 parts Coptis chinensis, 4-5 parts Atractylodes macrocephala, and 4-5 parts Ligusticum chuanxiong.

3. The method for preparing the traditional Chinese medicine composition for treating toothache according to claim 1 or 2, characterized in that, The preparation method includes the following steps: (1) After washing and drying all raw materials, clean raw materials are obtained; (2) The clean raw material is mixed with water and boiled. After the boiling is completed, it is filtered to obtain the first filtrate and the filter residue. (3) The filter residue is mixed with water again and boiled. After the process is completed, it is filtered to obtain the second filtrate. (4) Combine the first filtrate and the second filtrate to obtain the decoction; (5) Concentrate the decoction to obtain concentrated decoction, thus completing the preparation.

4. The method for preparing the traditional Chinese medicine composition for treating toothache according to claim 3, characterized in that, In step (2), the weight ratio of the clean raw material to water is 1:3~4; the decocting time is 30~40 minutes.

5. The method for preparing the traditional Chinese medicine composition for treating toothache according to claim 3, characterized in that, In step (3), the weight ratio of the filter residue to water is 1:4~5; the decocting time is 40~50min.

6. The method for preparing the traditional Chinese medicine composition for treating toothache according to claim 3, characterized in that, In step (5), the volume of the decoction is concentrated to 1 / 2 to 2 / 3 of the original volume.

7. A method for preparing the traditional Chinese medicine composition for treating toothache according to claim 1 or 2, characterized in that, The preparation method includes the following steps: (i) After crushing all raw materials, dry them to obtain raw material powder; (ii) Heat the honey to remove moisture, stirring constantly to prevent burning, to obtain refined honey; (iii) The raw material powder is mixed with the refined honey and stirred. The mixture is first made into strips and then into pills to obtain honey pills, thus completing the preparation.

8. The method for preparing the traditional Chinese medicine composition for treating toothache according to claim 7, characterized in that, In step (i), the raw material powder is passed through an 80-100 mesh sieve.

9. The method for preparing the traditional Chinese medicine composition for treating toothache according to claim 7, characterized in that, In step (iii), the weight ratio of the raw material powder to the refined honey is 1:1 to 1.5.