Yang warming, blood control and hemostasis formula 1 and application thereof in digestive tract hemorrhage

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a Yang warming, blood control and hemostasis formula I and application thereof in gastrointestinal hemorrhage, and is particularly suitable for critical patients with hemorrhagic shock. The prescription is composed of 30-60 g of red halloysite, 25 g of prepared rehmannia root, 10-15 g of prepared radix aconiti lateralis preparata (decocted for 30 min), 10 g of dried ginger, 15-30 g of roasted rhizoma atractylodis macrocephalae, 10 g of colla corii asini (melted by heat), 10 g of radix scutellariae, 15 g of cacumen biotae, 10 g of cuttlebone, 30 g of polished round-grained rice, 10 g of charred folium artemisiae argyi and 5-10 g of honey-fried licorice root. The preparation method comprises the following steps: decocting the prepared black radix aconiti lateralis preparata for 30 minutes; the red halloysite is divided into two parts (30-60 g of the red halloysite is taken after being mixed with the decoction and 10 g of the powder), the decoction process is optimized, and the hemostasis time is Melting colla corii asini by heat to control the dissolution rate; the red halloysite micro powder (the particle size is less than or equal to 150 microns) is used for cooperating with the decoction to quickly form a hemostatic barrier. According to the prescription, through a three-way synergistic mechanism of warming yang and relieving desertion (prepared radix aconiti lateralis praeparata slices and dried ginger), controlling blood and stopping bleeding (red halloysite and folium artemisiae argyi charcoal) and enriching blood and nourishing yin (prepared rhizome of rehmannia and donkey-hide gelatin), the hemostasis efficiency is remarkably improved, rebleeding is prevented, and the survival rate of critical patients is increased.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine compositions, in particular to a Yang-warming and blood-collecting and hemostatic No. 1 prescription and its application in digestive tract hemorrhage. BACKGROUND

[0002] Digestive tract hemorrhage is a common clinical emergency, among which the incidence and mortality of acute upper digestive tract hemorrhage are high, seriously threatening the life and health of patients. Modern medicine has made some progress in diagnosis and early treatment through new drugs (such as somatostatin, proton pump inhibitors), endoscopic techniques (such as metal titanium clips, microwave therapy), etc., but for critically ill patients with aggravated condition after initial treatment and transferred to intensive care unit, the mortality is still difficult to effectively reduce, which becomes a bottleneck for western medicine treatment.

[0003] From the perspective of traditional Chinese medicine, digestive tract hemorrhage belongs to the category of "hematemesis" and "melena", and those accompanied by hemorrhagic shock are classified as "hemorrhagic syndrome". The earliest record of its etiology is related to "yang qi inverting" and "qi inverting and running wildly" in the Canon of Internal Medicine, such as "Taiyang inverting, stiff and blood vomiting" in the Treatise on Inversions. In the Golden Chamber, Zhang Zhongjing of the Eastern Han Dynasty further classified "blood loss" into "near blood" and "far blood", and proposed classic prescriptions such as Xie Xin Tang, Huangtu Tang, and Baiye Tang. The four methods of "stopping blood, removing stasis, calming blood, and tonifying blood" summarized by Wang Qingren in the Qing Dynasty laid the foundation for later treatment. However, traditional prescriptions have the following limitations in the treatment of critically ill patients: It is difficult to balance warming yang and hemostasis: Most schemes only focus on hemostasis or tonifying deficiency, and cannot correct the coexistence of yang qi deficiency (such as cold limbs, sudden blood pressure drop) and yin blood loss (such as persistent hematemesis / black stool). For example, Baiye Tang can warm yang and stop bleeding, but it lacks targeted intervention for coagulation mechanism disorder in shock state; Huangtu Tang can tonify blood and stop bleeding, but it is difficult to reverse yang qi collapse.

[0004] Defects in decoction process affect efficacy: Toxic drugs such as Zhizhu in traditional decoction have not been strictly standardized for detoxification process (such as insufficient decoction time leading to risk of aconitine residue), and hemostatic components such as red shilajit have low dissolution efficiency (dissolution rate less than 30%) due to whole grain decoction, and improper melting method of Ejiao can easily lead to loss of effective components.

[0005] Lack of standardized treatment scheme for critically ill patients: Existing integrated traditional Chinese and western medicine schemes focus on mild patients, and lack of clear compatibility specifications and process standards for synergistic treatment of severe cases (with hemorrhagic shock), making it difficult to achieve the dual goals of rapid hemostasis (need to control active bleeding within 24 hours) and anti-shock.

[0006] In recent years, clinical research has shown that the key role of red shilajit in hemostasis (such as adsorbing gastric acid, protecting gastric mucosal barrier) and the mechanism of aconite detoxification and efficiency enhancement have gradually been valued, but how to effectively integrate these characteristics into the prescription while meeting the high efficiency and safety needs of critically ill patients remains a problem to be solved.

[0007] Therefore, it is of great significance to develop a traditional Chinese medicine prescription which can quickly stop bleeding, warm yang and astringe, and improve the efficacy through process optimization, to improve the success rate of treatment and reduce the mortality rate of severe patients. The application improves the efficacy of the prescription in the treatment of critical gastrointestinal bleeding by improving the application mode of red ocher, the pre-decoction process of black aconite and the dissolution control of donkey-hide gelatin, and fills the gap in the prior art. SUMMARY

[0008] In view of the deficiencies in the treatment of gastrointestinal bleeding with hemorrhagic shock in the prior art, the application provides a warm yang blood-stopping No. 1 prescription, which can quickly control bleeding and improve shock state through the synergistic effect of warming yang and astringe, and shorten the onset time and improve safety through process innovation, thereby improving the efficacy of critical patients.

[0009] The technical solution adopted by the application to solve the technical problems is that the warm yang blood-stopping No. 1 prescription is composed of the following traditional Chinese medicines in parts by weight: red ocher 30-60g, prepared rehmannia 25g, black aconite 10-15g, dried ginger 10g, fried atractylodes 15-30g, donkey-hide gelatin 10g, radix scutellariae 10g, cypress leaf 15g, sea squirt 10g, polished rice 30g, mugwort leaf charcoal 10g, and fried licorice 5-10g; wherein: The black aconite needs to be decocted separately for 30 minutes to reduce toxicity; The donkey-hide gelatin is added to the decoction after being melted with a small amount of hot water; The red ocher is divided into two parts: 30-60g is decocted with other medicinal materials, and the other 10g is ground into a powder with a particle size of ≤150μm, which is taken after the decoction is prepared.

[0010] Specifically, the amount of red ocher is 30g, and the particle size of the powder is ≤120μm.

[0011] Specifically, the amount of red ocher is 60g, and the particle size of the powder is ≤100μm.

[0012] Specifically, the amount of black aconite is 10g.

[0013] Specifically, the amount of black aconite is 15g.

[0014] Specifically, the amount of fried atractylodes is 15g.

[0015] Specifically, the amount of fried atractylodes is 30g.

[0016] Specifically, the amount of fried licorice is 5g.

[0017] Specifically, the amount of fried licorice is 10g.

[0018] The application provides application of Yang-warming blood-collecting hemostasis No.1 prescription in preparation of a medicine for treating digestive tract hemorrhage with hemorrhagic shock, and the medicine significantly improves hemostasis efficiency, prevents rebleeding, and improves survival rate of severe patients through a three-way synergistic mechanism of Yang-warming, blood-collecting hemostasis, and blood-enriching and Yin-nourishing.

[0019] The application has the following beneficial effects: Accurate syndrome differentiation and efficient synergy: aiming at the core pathogenesis of "hemorrhagic collapse" (asthenia of Yang-qi and unconsolidation of Yin-blood), the Yang-warming, hemostasis, and blood-enriching three elements are innovatively integrated in layers, and the curative effect is improved compared with traditional single-ingredient prescriptions.

[0020] Process optimization improves efficacy: the red lead ore granule size is controlled (≤150 μm) to accelerate the aggregation of blood coagulation factors, the red lead ore in the decoction is released slowly and protected by a film, and the hemostasis time is shortened compared with traditional decoctions; the strict pre-decoction detoxification process of prepared aconite root tablets ensures the safety of long-term medication (no adverse reactions such as arrhythmia are found in clinical practice).

[0021] Reducing recurrence and improving prognosis: the blood-enriching compatibility of prepared aconite root tablets, rehmannia, and donkey-hide gelatin corrects anemic state (the hemoglobin is increased by more than 15 g / L), and the fried atractylodes and fried licorice regulate the function of the spleen and stomach, which significantly reduces the risk of rebleeding within 30 days.

[0022] Safety verification: the prepared aconite root tablets after processing and the decoction time are controlled, and the aconitine residual amount detected by HPLC is far below the safety threshold value (<0.05 mg / L), which is suitable for long-term use by critical patients. DETAILED DESCRIPTION

[0023] In order to make the technical means, creative features, purposes and effects achieved by the application easy to understand, the application is further described below in combination with specific embodiments.

[0024] The Yang-warming blood-collecting hemostasis No.1 prescription of the application is composed of the following Chinese medicines (by weight): red lead ore 30-60 g, prepared aconite root tablets 10-15 g, dried ginger 10 g, fried atractylodes 15-30 g, donkey-hide gelatin 10 g, radix scrophulariae 10 g, cypress leaf 15 g, cuttlefish bone 10 g, glutinous rice 30 g, mugwort leaf charcoal 10 g, and fried licorice 5-10 g.

[0025] Prepared aconite root tablets pre-decoction process: The prepared aconite root tablets are separately decocted in water for 30 minutes (water covers 3 cm of the medicinal materials), the aconitine is hydrolyzed to reduce toxicity (aconitine residual amount <0.05 mg / L), and the effective components (such as norlaudanosine) are promoted to dissolve.

[0026] Technical significance: the traditional decoction does not sufficiently reduce the toxicity of the aconite root tablets, which may cause side effects such as arrhythmia, and the process ensures the safety while ensuring the timely effect of the Yang-restoring and resuscitation medicine.

[0027] Layered use of red lead ore: Red ochre is divided into two parts: 30-60g is decocted together with other medicinal materials, and the other 10g is ground into a powder with a particle size ≤150μm (preferably 100-120μm).

[0028] Synergistic mechanism of decoction: The red ochre in the decoction releases hydroxyaluminosilicate colloids through long-term decoction, forming a protective film on the surface of the gastric mucosa; the powder particles taken by dissolving in water quickly adsorb fibrinogen in the blood, accelerating the formation of blood clots in situ at the bleeding point, thus achieving the dual effect of "long-lasting protective film of decoction + targeted hemostasis of powder".

[0029] Technical advantages: Compared with traditional whole-grain decoction (hemostasis time > 48 hours), this process shortens the hemostasis time to 12-24 hours, significantly improving the success rate of rescuing critically ill patients.

[0030] Precise control of donkey-hide gelatin dissolving process: After melting the donkey-hide gelatin with a small amount of hot water (60-80℃), add the cooled decoction (temperature controlled at 40-50℃) to avoid high temperature damaging the collagen and amino acid components.

[0031] Technical effects: Ensures that blood-replenishing components (such as glycine and arginine) are fully preserved, and works synergistically with Rehmannia glutinosa and japonica rice to nourish yin and stomach, improving the state of yin and blood depletion caused by shock.

[0032] Overall compatibility and synergy mechanism: Warming Yang and Strengthening the Body Layer: Prepared black aconite root (decocted first) and dried ginger are extremely pungent and hot, restoring Yang and rescuing from collapse, rapidly raising blood pressure and improving cold extremities; Hemostatic layer: Red ochre (dual-form application) adsorbs gastric acid and protects the ulcer surface, Artemisia argyi charcoal astringes and stops bleeding, and Platycladus orientalis leaves cool the blood and stop bleeding. The three drugs work together to form a physical-chemical composite hemostatic barrier. Blood-nourishing and health-protecting layer: Rehmannia glutinosa and donkey-hide gelatin nourish yin and blood, stir-fried Atractylodes macrocephala and prepared licorice root invigorate the spleen and replenish qi, and japonica rice harmonizes the medicinal properties, addressing both the symptoms and the root cause to reduce the risk of rebleeding.

[0033] The present invention is further illustrated below with clinical cases. The cases are all patients with gastrointestinal bleeding and hemorrhagic shock admitted to Yuncheng Central Hospital of Shanxi Province from January 2024 to December 2024. They meet the diagnostic criteria of Western medicine (hematemesis / melena, hemoglobin decrease ≥30g / L, systolic blood pressure <90mmHg) and the diagnostic criteria of traditional Chinese medicine "bleeding collapse syndrome" (deficiency of yang qi and instability of yin blood). Patients who died before treatment, refused Chinese medicine, or had gastrointestinal perforation were excluded.

[0034] Example 1: Gastric ulcer bleeding with shock (Red ochre 30g / processed black aconite root 10g / fried atractylodes macrocephala 15g / processed licorice root 5g) Prescription composition: Cinnabar 30g (of which 10g of powder, particle size ≤120μm), Rehmannia 25g, prepared black aconite tablet 10g (first decoct for 30 minutes), dried ginger 10g, fried atractylodes 15g, donkey-hide gelatin 10g (melted), Scutellaria 10g, Biota leaf 15g, cuttlefish bone 10g, polished rice 30g, mugwort leaf charcoal 10g, prepared licorice 5g.

[0035] Case: A 56-year-old male patient was admitted to hospital due to "hematemesis for 3 hours, and confusion for 1 hour". He had a history of gastric ulcer for 5 years. Upon admission, he had about 800mL of hematemesis and 2 episodes of melena, with about 500g of stool. Physical examination showed body temperature 36.1℃, pulse 128 times / min, respiration 24 times / min, blood pressure 75 / 45mmHg, pale face, cold limbs, pale tongue, white fur, and weak pulse. Western medicine diagnosis: acute upper gastrointestinal bleeding (gastric ulcer) with hemorrhagic shock; TCM diagnosis: bleeding and blood loss (yang qi deficiency, yin blood instability).

[0036] Treatment process: Western medicine basic treatment: somatostatin 0.25mg / h continuous infusion, esomeprazole 80mg intravenous infusion, 8mg / h pump in, and 400mL of blood transfusion.

[0037] TCM combined regimen: prepared black aconite tablet was first decocted for 30 minutes, then the remaining medicinal materials (cinnabar 30g) were added and water was added to cover 3cm. After boiling with large fire, it was decocted with small fire for 30 minutes. The medicinal dregs were decocted for another 20 minutes, and the medicinal liquid was combined. Donkey-hide gelatin was melted and added to the warm medicinal liquid. Each time 300mL of medicinal liquid was taken, and 10g of cinnabar powder (particle size ≤120μm) was added for oral administration, 3 times a day.

[0038] Observation of curative effect: 12 hours after treatment: hematemesis stopped, blood pressure rose to 85 / 55mmHg (systolic pressure rose by >10mmHg), pulse decreased to 110 times / min, and limbs turned warm; 24 hours after treatment: no more bleeding, hemoglobin increased from 62g / L to 75g / L (increased by 13g / L), and fecal occult blood test was weakly positive; 72 hours after treatment: fecal occult blood test turned negative, blood pressure stabilized at 100 / 60mmHg, pulse was 90 times / min, and shock was corrected; 7 days after admission: transferred out of ICU, hemoglobin recovered to 95g / L, and all vital signs were normal; 1 month follow-up: no recurrence of hematemesis / melena, good healing of ulcer by gastroscopy, and 28-day survival rate was 100%.

[0039] Curative effect determination: recovery (bleeding stopped, symptoms and signs disappeared, and ulcer healed).

[0040] Example 2: Liver cirrhosis esophageal and gastric fundus varices rupture and bleeding (cinnabar 45g / prepared black aconite tablet 12g / fried atractylodes 20g / prepared licorice 7g) Prescription composition: Cinnabar 45g (powder 10g, particle size ≤ 150μm), Rehmannia 25g, prepared black appendage 12g (first decoct for 30 minutes), dried ginger 10g, fried atractylodes 20g, donkey-hide gelatin 10g (melted), Scutellaria 10g, Biota leaf 15g, sea squirt 10g, polished rice 30g, mugwort leaf charcoal 10g, prepared licorice 7g.

[0041] Case: Female patient, 68 years old, admitted to hospital for "black stool for 5 days, syncope once". Past history of cirrhosis for 10 years, on admission, 6 times of asphalt-like stool, about 1200g, syncope once; physical examination: body temperature 35.8℃, pulse 135 times / min, respiration 26 times / min, blood pressure 65 / 40mmHg, skin mottling, tongue purple, thin white fur, pulse is thin. Western medicine diagnosis: esophageal and gastric varices rupture bleeding with hemorrhagic shock; TCM diagnosis: bleeding syndrome (yang qi collapse, yin blood instability).

[0042] Treatment process: Western medicine treatment: same as example 1 (transfusion 800mL); Traditional Chinese medicine regimen: prepared black appendage is first decocted for 30 minutes, cinnabar 45g and other medicinal materials are added, and after boiling with large fire, it is decocted with small fire for 30 minutes; After combining the medicinal liquid, add donkey-hide gelatin melted liquid; Cinnabar powder 10g is added for each time, and it is taken with water, 3 times a day.

[0043] Observation of curative effect: 24 hours after treatment: the number of black stool is reduced to 1 time (about 50g), blood pressure rises to 75 / 50mmHg (increases by 10mmHg), pulse drops to 120 times / min, skin mottling subsides; 48 hours after treatment: no more defecation, hemoglobin increases from 58g / L to 70g / L (increases by 12g / L), platelet count is stable; 72 hours after treatment: fecal occult blood is weakly positive, blood pressure is 90 / 55mmHg, pulse is 100 times / min, liver and kidney function is improved; 10 days after admission: transferred out of ICU, gastroscopy shows thrombosis of bleeding point, no adverse reactions such as nausea and vomiting; Follow-up for 1 month: no recurrence of bleeding, ascites decreased, 28-day survival rate 100%.

[0044] Curative effect: marked effect (active bleeding stopped, varicose inflammation reduced).

[0045] Example 3: acute erosive hemorrhagic gastritis with shock (cinnabar 60g / prepared black appendage 15g / fried atractylodes 30g / prepared licorice 10g) Prescription composition: red ocher 60g (10g of powder, particle size ≤100 μm), rehmannia 25g, prepared black appendage 15g (first decoct 30 minutes), dried ginger 10g, fried atractylodes 30g, donkey-hide gelatin 10g (melted), scutellaria 10g, cypress leaves 15g, cuttlefish bone 10g, polished rice 30g, mugwort leaf charcoal 10g, prepared licorice 10g.

[0046] Case: male patient, 45 years old, admitted to hospital for "vomiting blood after drinking for 2 hours, restlessness". No history of disease, about 1000 mL of vomit containing blood clots when admitted to hospital; physical examination: body temperature 36.0℃, pulse 140 times / min, respiration 28 times / min, blood pressure 60 / 35mmHg, restlessness, limbs cold, tongue pale and greasy fur, pulse fine and rapid. Western medicine diagnosis: acute erosive hemorrhagic gastritis with hemorrhagic shock; TCM diagnosis: bleeding syndrome (yang qi collapse, yin blood instability).

[0047] Treatment process: Western medicine treatment: same as example 1 (transfusion of 600 mL); Traditional Chinese medicine regimen: prepared black appendage is first decocted for 30 minutes (aconitine residual amount <0.05 mg / L detection standard), red ocher 60g is decocted with other medicinal materials for 30 minutes; red ocher micro powder (particle size ≤100 μm) is taken orally 3 times a day.

[0048] Observation of curative effect: 18 hours after treatment: vomiting of blood stopped, blood pressure rose to 80 / 50mmHg (rose by 20mmHg), restlessness relieved; 36 hours after treatment: hemoglobin increased from 55g / L to 68g / L (increased by 13g / L), gastric mucosa erosion began to scab; 72 hours after treatment: fecal occult blood turned negative, blood pressure 95 / 60mmHg, pulse 95 times / min, shock corrected; 8 days in hospital: recovered well, no abdominal pain / nausea, rechecked gastroscopy for erosion healing; Follow-up for 1 month: no recurrence of bleeding, 28-day survival rate 100%.

[0049] Curative effect determination: recovery.

[0050] Example 4: Gastric cancer related gastrointestinal hemorrhage (red ocher 40g / prepared black appendage 13g / fried atractylodes 25g / prepared licorice 8g) Prescription composition: red ocher 40g (10g of powder, particle size ≤150 μm), rehmannia 25g, prepared black appendage 13g (first decoct 30 minutes), dried ginger 10g, fried atractylodes 25g, donkey-hide gelatin 10g (melted), scutellaria 10g, cypress leaves 15g, cuttlefish bone 10g, polished rice 30g, mugwort leaf charcoal 10g, prepared licorice 8g.

[0051] Case: A 72-year-old female patient was admitted to hospital due to "hematemesis and melena for 1 day, and unconsciousness". The patient had a history of hypertension and coronary heart disease. Upon admission, the patient had about 600 mL of hematemesis and 3 episodes of melena, with about 400 g of stool. Physical examination showed a body temperature of 35.5℃, a pulse of 110 beats per minute, a respiration of 22 times per minute, a blood pressure of 70 / 45 mmHg, lethargy, and moist rales in both lungs (decompensated heart failure). Western medical diagnosis: acute upper gastrointestinal bleeding (possible gastric cancer) with hemorrhagic shock; TCM diagnosis: bleeding and blood loss (yang qi deficiency and yin blood instability).

[0052] Treatment process: Western medicine treatment: same as Example 1 (400 mL of blood transfusion, diuretics to control heart failure symptoms); TCM regimen: decoct Shuihepian for 30 minutes, then co-decoct with Hongshilipi 40g and other medicinal materials; take Hongshilipi powder 3 times a day.

[0053] Observation of curative effect: After 36 hours of treatment: no more hematemesis, 1 episode of melena (small amount), blood pressure increased to 80 / 50 mmHg (consciousness improved); After 72 hours of treatment: weakly positive for fecal occult blood, hemoglobin increased from 60 g / L to 72 g / L (an increase of 12 g / L), and heart failure symptoms were stable; After 12 days of hospitalization: bleeding was controlled (no active hematemesis / melena), and the patient was transferred to a general ward due to underlying diseases, with no drug-related adverse reactions; Follow-up for 1 month: no recurrence of hematemesis / melena, gastroscopy showed that the tumor edge bleeding stopped (biopsy showed no fresh bleeding focus), and the 28-day survival rate was 100%.

[0054] Curative effect: effective (bleeding reduction ≥80%, symptoms improved).

[0055] Example 5: Duodenal ulcer bleeding with shock (Hongshilipi 50g / Shuihepian 14g / Fried Baizhu 22g / Fried Gancao 9g) Prescription composition: Hongshilipi 50g (powder 10g, particle size ≤150μm), Shudi 25g, Shuihepian 14g (decoct for 30 minutes), Dry Ginger 10g, Fried Baizhu 22g, Aglaia 10g (melted), Huangqi 10g, Cai Baizhi 15g, Haipiaoxi 10g, Jingmi 30g, Aiyecarbon 10g, Fried Gancao 9g.

[0056] Case: A 50-year-old male patient was admitted to hospital due to "repeated melena for 1 week, aggravated with palpitation for 2 hours". The patient had a history of duodenal ulcer. At admission, the patient had melena for 5 times, with a volume of about 800g, and palpitation and sweating. Physical examination showed body temperature 36.2℃, pulse 130 times / min, respiration 25 times / min, blood pressure 75 / 50 mmHg, pale face, thin white tongue fur, and weak pulse. Western medical diagnosis: duodenal ulcer hemorrhage with hemorrhagic shock; TCM diagnosis: blood loss syndrome (yang qi collapse, yin blood instability).

[0057] Treatment process: Western medicine treatment: same as Example 1 (transfusion of 200 mL); Traditional Chinese medicine regimen: black appendage pieces were decocted for 30 minutes (to ensure safety), and 50g of cinnabar was added into the decoction; the scattered agent was taken 3 times a day.

[0058] Efficacy observation: 24 hours after treatment: melena stopped, blood pressure rose to 85 / 55 mmHg (rose by 10 mmHg), pulse decreased to 115 times / min, and palpitation relieved; 48 hours after treatment: hemoglobin increased from 65g / L to 78g / L (increased by 13g / L), and the duodenal ulcer surface began to scab; 72 hours after treatment: fecal occult blood turned negative, blood pressure was 100 / 65 mmHg, and pulse was stable; 6 days after admission: recovered and discharged from hospital without abdominal discomfort; 1 month of follow-up: no recurrence of hemorrhage, gastroscopy showed ulcer healing, and 28-day survival rate was 100%.

[0059] Efficacy determination: cured.

[0060] The above shows and describes the basic principles, main features and advantages of the present application. It should be understood by those skilled in the art that the present application is not limited by the above examples, and the above examples and descriptions in the specification are only to illustrate the principles of the present application. Without departing from the spirit and scope of the present application, various changes and improvements can be made to the present application, and these changes and improvements all fall within the scope of the present application. The scope of protection of the present application is defined by the appended claims and their equivalents.

Claims

1. Wen Yang She Xie Zhi Xie 1 Hao Fang and, characterized in that, It is composed of the following weight parts of traditional Chinese medicines: red shilajit 30-60g, prepared rehmannia 25g, prepared black aconite tablet 10-15g, dried ginger 10g, fried atractylodes 15-30g, donkey-hide gelatin 10g, scutellaria 10g, biota leaf 15g, sea squirt 10g, polished rice 30g, mugwort leaf charcoal 10g, and fried licorice 5-10g; wherein: The prepared black aconite tablet needs to be decocted with water for 30 minutes to reduce toxicity; The donkey-hide gelatin is added after being melted with a small amount of hot water; The red shilajit is divided into two parts: 30-60g is decocted with other medicinal materials, and 10g is ground into a powder with a particle size of ≤150μm, which is taken after the decoction is prepared.

2. The Wen Yang Shexue Zhi Xue No. 1 prescription of claim 1, characterized in that: The amount of the red shilajit is 30g, and the particle size of the powder is ≤120μm. 3.The Wen Yang Shexue Zhi Xue No.1 prescription of claim 1, characterized in that: The amount of the red shilajit is 60g, and the particle size of the powder is ≤100μm.

4. The Wen Yang Shexue Zhi Xue No. 1 prescription of claim 1, characterized in that: The amount of the prepared black aconite tablet is 10g.

5. The Wen Yang Shexue Zhi Xue No. 1 prescription of claim 1, characterized in that: The amount of the prepared black aconite tablet is 15g.

6. The Wen Yang Shexue Zhi Xue No. 1 prescription of claim 1, characterized in that: The amount of the fried atractylodes is 15g.

7. The Wen Yang Shexue Zhi Xue No. 1 prescription of claim 1, characterized in that: The amount of the fried atractylodes is 30g.

8. The Wen Yang Shexue Zhi Xue No. 1 prescription of claim 1, characterized in that: The amount of the fried licorice is 5g. 9.The Wen Yang Shexue Zhi Xue No.1 prescription of claim 1, characterized in that: The amount of the fried licorice is 10g.

10. The application of the Yang-warming blood-collecting and bleeding-stopping No.1 prescription in any of claims 1-9 in the preparation of a medicine for treating digestive tract hemorrhage with hemorrhagic shock.