Method for reconstructing interdental papilla using hyaluronic acid

Abstract

The present invention relates to a method for reconstructing an interdental papilla using hyaluronic acid. Compared with existing diagnosis and treatment methods, the method for reconstructing the interdental papilla according to one aspect of the present invention can conveniently reconstruct a missing or retracted interdental papilla. In addition, the method for reconstructing the interdental papilla according to one aspect of the present invention can effectively reconstruct the interdental papilla without pain or side effects. In addition, the method for reconstructing the interdental papilla according to the present invention is very effective as a remedial diagnosis and treatment for quickly solving an unexpected problem such as gingival sagging or interdental papilla loss in dental diagnosis and treatment.

Description

TECHNICAL FIELD

[0001] The present application relates to a method for reconstruction of interdental papilla using hyaluronic acid. BACKGROUND

[0002] The interdental papilla is a part of the free gingiva, which occupies the space between two adjacent teeth, connecting the free gingival margin in a flower-like pattern at the dental arch.

[0003] The interdental papilla plays a role in firmly supporting the teeth to assist the stability of the teeth and prevent food residue or foreign matter from being caught between the teeth. In addition, the interdental papilla provides a natural balanced smile by filling the space between the teeth, thereby also having an aesthetic function.

[0004] The interdental papilla can be lost due to abnormal tooth morphology, inappropriate restoration, incorrect oral hygiene management method, periodontal disease, etc. When the interdental papilla is lost or retracted, a so-called black triangle (black triangle syndrome or retraction of the interdental papilla) occurs, leading to various functional and aesthetic problems listed above.

[0005] Therefore, in order to solve the problem of loss of the interdental papilla, a gum reconstruction procedure using transplanted gingival tissue, a resin filling procedure to fill the space between the teeth with resin, a restoration adjustment or orthodontic treatment using a crown, a bridge, etc. to narrow the gap between the teeth are currently being used. However, the reconstruction method of the interdental papilla known so far has a complex diagnosis and treatment process, induces pain, or requires a long time to reconstruct the interdental papilla, not only is the treatment cost high, but also shows the essential limitation that the effect of the reconstruction of the interdental papilla is minimal, which is not accepted by patients.

[0006]

PRIOR ART DOCUMENTS

PATENT DOCUMENTS

[0007] According to an aspect, the present application aims to reconstruct the lost or retracted interdental papilla.

[0008] According to an aspect, the present application aims to remove the black triangle.

[0009] According to an aspect, the present application aims to reconstruct the interdental papilla and remove the black triangle by a convenient method.

[0010] According to an aspect, an object of the present application is to provide a method for reconstructing interdental papilla without side effects.

[0011] According to an aspect, an object of the present application is to provide a composition for reconstructing interdental papilla, which improves pain caused by administration (injection).

[0012] According to an aspect, an object of the present application is to provide a method for reconstructing interdental papilla in a simple and economical manner compared to existing diagnosis and treatment methods.

[0013] According to an aspect, an object of the present application is to increase the soft tissue of interdental papilla (increase in amount and increase in volume).

[0014] According to an aspect, an object of the present application is to promote increase in the horizontal thickness and vertical height of interdental papilla.

[0015] According to an aspect, an object of the present application is to promote the phenomenon of creeping attachment.

[0016] The subject matter to be solved in the embodiments is not limited to the above, but includes objects or effects that can be understood from the means for solving the subject matter or the modes of implementation described below.

[0017] To achieve the above object, one aspect of the present application provides a method for reconstructing interdental papilla.

[0018] In addition, the present application according to the above aspect provides a method for reconstructing interdental papilla, wherein the method includes a composition administration step of administering a composition including hyaluronic acid or a pharmaceutically acceptable salt of the hyaluronic acid to a gingiva, the composition including a composition having a complex viscosity of 200 to 850 Pa.s.

[0019] In addition, the present application according to the above aspect provides a method for reconstructing interdental papilla, wherein the administration step includes administering 0.005 to 0.05 cc of the composition.

[0020] In addition, the present application according to the above aspect provides a method for reconstructing interdental papilla, wherein the administration step includes administering the composition 1 to 10 times at 0.001 to 0.01 cc each time.

[0021] In addition, the present application according to the above aspect provides a method for reconstructing interdental papilla, wherein the administration step includes administering the composition to a gingiva having an area of 0.1 to 4 mm 2 In addition, the present application according to the above aspect provides a method for reconstructing interdental papilla, wherein the administration step includes administering the composition to a gingiva having an area of 0.1 to 4 mm

[0022] In addition, the present application provides a method for reconstructing interdental papilla according to the above-described aspect, wherein the composition comprises a gel preparation.

[0023] In addition, the present application provides a method for reconstructing interdental papilla according to the above-described aspect, wherein the interdental papilla reconstruction rate of the above-described method is 70% or more, as represented by the following mathematical formula 1, [mathematical formula 1] Interdental papilla reconstruction rate (%) = 100 x area of black triangle after application of composition / area of black triangle before application of composition.

[0024] In addition, the present application provides a method for reconstructing interdental papilla according to the above-described aspect, wherein the composition is applied using a needle having a gauge of 25 to 35.

[0025] In addition, the present application provides a method for reconstructing interdental papilla according to the above-described aspect, wherein the application step comprises applying the composition to a position 1 to 3 mm below the tip of the interdental papilla.

[0026] In addition, the present application provides a method for reconstructing interdental papilla according to the above-described aspect, wherein the above-described method further comprises a shaping step.

[0027] In addition, the present application provides a method for reconstructing interdental papilla according to the above-described aspect, wherein the above-described method is performed at intervals of 2 to 4 weeks.

[0028] In addition, the present application provides a kit for reconstructing interdental papilla, comprising: a composition comprising hyaluronic acid or a pharmaceutically acceptable salt thereof; and a medical instruction manual describing the above-described method for reconstructing interdental papilla.

[0029] The method for reconstructing interdental papilla according to an aspect of the present application can conveniently reconstruct missing or retracted interdental papilla, compared to conventional medical treatment methods. In addition, the method for reconstructing interdental papilla according to an aspect of the present application can effectively reconstruct interdental papilla in a manner without pain or side effects. In addition, the method for reconstructing interdental papilla of the present application is very effective as a remedial medical treatment for rapidly solving problems such as unexpected gum recession or missing interdental papilla, which occur in dental medical treatment.

[0030] The various advantageous effects and features of the present application are not limited to those described above and will become apparent to those skilled in the art from the following detailed description. BRIEF DESCRIPTION OF DRAWINGS

[0031] Figure 1 is a graph showing the complex viscosity of the hyaluronic acid gel contained in the composition and the interdental papilla reconstruction rate (%) over time.

[0032] Figure 2 is a graph showing the dose of the composition and the interdental papilla reconstruction rate (%) over time.

[0033] Figure 3 is a graph showing the administration position and the administration area of the composition (the black frame in which the black dot is shown indicates the administration position and (dot), the administration area). DETAILED DESCRIPTION

[0034] The present application can be modified in various ways, and can have various embodiments, and a specific embodiment will be specifically described. However, this is not intended to limit the present application to a specific embodiment, and it should be understood to include all modifications, equivalents, and alternatives included in the idea and technical scope of the present application.

[0035] In addition, the terms or words used in the specification and claims of the present application should not be interpreted as limited to generally or dictionary meanings, but should be interpreted as meanings and concepts in accordance with a principle that the inventor is able to appropriately define the concepts of the terms in order to most suitably explain the present application.

[0036] The terms including ordinal numbers such as second, first, etc. can be used to describe multiple constituent elements, but the above-described constituent elements are not limited to the above-described terms. The above-described terms are used only for the purpose of distinguishing one constituent element from another constituent element. For example, a second constituent element can be named a first constituent element without departing from the scope of the rights of the present application, and similarly, a first constituent element can be named a second constituent element. The term "and / or" includes a combination of multiple related recitations or any one of the multiple related recitations.

[0037] In addition, the terms used in the present application are only used to explain specific embodiments, and are not intended to limit the present application. The singular expression includes the plural expression, unless it is explicitly indicated otherwise in the context. In the present application, the terms "include" or "have" or the like should be understood to mean the existence of the features, numbers, steps, operations, constituent elements, components or combinations thereof described in the specification, not to preclude the existence or additional possibility of one or more other features, numbers, steps, operations, constituent elements, components or combinations thereof.

[0038] Unless otherwise defined, all terms including technical terms and scientific terms used in the present specification have the same meanings as those generally understood by those skilled in the art to which the present application pertains. The terms defined in a generally used dictionary should be interpreted as having meanings consistent with the meanings in the context of the relevant technology, and should not be interpreted as ideally or overly formally unless otherwise defined in the present specification.

[0039] Hereinafter, the present application will be described in detail.

[0040] According to an aspect of the present application, there is provided a method for reconstruction of interdental papilla.

[0041] According to an aspect of the present application, there is provided a method for reconstruction of interdental papilla, the method including a composition application step of applying a composition containing hyaluronic acid or a pharmaceutically acceptable salt thereof to a gingiva, the composition containing a composition having a complex viscosity of 200 to 850 Pa.s.

[0042] The hyaluronic acid is a non-sulfur polymer belonging to the glycosaminoglycan family, is widely present in mammalian tissues, has a non-branched structure, and is composed of an ordered repetition of a disaccharide composed of glucuronic acid and N-acetylglucosamine.

[0043] The hyaluronic acid has a very wide size, which can exceed 1000 kDa, and even reach 3000 to 9000 kDa in some tissues.

[0044] In the present application, the hyaluronic acid can be used as it is, or can be used by being salted in various ways using sodium or the like.

[0045] In the present specification, the term "pharmaceutically acceptable salt" can include all salts of a compound that are physiologically tolerable by a subject or target individual. The pharmaceutically acceptable salt is preferably a compound preparation that does not cause a serious irritation to an organism to which the compound is administered, and does not impair the biological activity and physical properties of the compound. The pharmaceutically acceptable salt can include: acid addition salts formed with non-toxic acids containing pharmaceutically acceptable anions, such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, hydrobromic acid, hydroiodic acid, and the like; acid addition salts formed with organic carbonic acids such as tartaric acid, formic acid, citric acid, acetic acid, trichloroacetic acid, trifluoroacetic acid, gluconic acid, benzoic acid, lactic acid, fumaric acid, maleic acid, salicylic acid, and the like; acid addition salts formed with sulfonic acids such as methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, and the like.

[0046] If the molecular weight of the hyaluronic acid or the pharmaceutically acceptable salt thereof is less than 500 kDa, it can cause inflammation of the skin, and if the molecular weight of the hyaluronic acid or the sodium salt thereof exceeds 3000 kDa, it is difficult to effectively apply it to the gingival junction tissue layer due to the excessively large molecular weight, and thus can not be preferred.

[0047] According to an aspect, the molecular weight of the hyaluronic acid or the pharmaceutically acceptable salt thereof can be 1000 to 3000 kDa. Alternatively, the molecular weight of the hyaluronic acid or the pharmaceutically acceptable salt thereof can be 1300 to 2500 kDa, or 1300 to 2300 kDa or 1500 to 2000 kDa.

[0048] According to an aspect, the above composition can include a composition having a complex viscosity of 200 to 850 Pa.s. Specifically, the above composition can have a complex viscosity of 200 Pa.s or more, or 250 Pa.s or more, or 300 Pa.s or more, or 350 Pa.s or more, or 400 Pa.s or more, or 450 Pa.s or more, or 500 Pa.s or more, or 550 Pa.s or more, or 600 Pa.s or more, or 610 Pa.s or more, or 630 Pa.s or more, or 650 Pa.s or more, or 670 Pa.s or more, or 690 Pa.s or more, or 700 Pa.s or more, or 710 Pa.s or more, or 720 Pa.s or more, or 730 Pa.s or more, or 740 Pa.s or more, or 750 Pa.s or more, or 760 Pa.s or more, or 770 Pa.s or more, or 780 Pa.s or more, or 790 Pa.s or more, or 800 Pa.s or more, or 850 Pa.s or less, or 840 Pa.s or less, or 830 Pa.s or less, or 820 Pa.s or less, or 810 Pa.s or less, or 800 Pa.s or less, or 790 Pa.s or less, or 780 Pa.s or less, or 770 Pa.s or less, or 760 Pa.s or less, or 750 Pa.s or less, or 740 Pa.s or less, or 730 Pa.s or less, or 720 Pa.s or less, or 710 Pa.s or less, or 700 Pa.s or less, or 690 Pa.s or less, or 670 Pa.s or less, or 650 Pa.s or less, or 630 Pa.s or less, or 610 Pa.s or less, or 600 Pa.s or less, or 550 Pa.s or less, 500 Pa.s or less, 450 Pa.s or less, 400 Pa.s or less, 350 Pa.s or less, 300 Pa.s or less, 250 Pa.s or less.

[0049] In the above aspect, the above composition can have a complex viscosity of 200 to 850 Pa.s, or 300 to 850 Pa.s, or 400 to 850 Pa.s, or 500 to 850 Pa.s, or 500 to 800 Pa.s, or 500 to 750 Pa.s, or 550 to 750 Pa.s, or 570 to 750 Pa.s, or 570 to 730 Pa.s, or 590 to 730 Pa.s, or 600 to 710 Pa.s, or 601 to 700 Pa.s.

[0050] In the present specification, the term "administration" refers to introduction of each component of a therapy for treating or ameliorating a condition by any appropriate method, and the administration route can be oral or non-oral, and various routes can be used as long as the target site (tissue, blood vessel, muscle, organ, body cavity, etc.) can be reached. The above term "administration" encompasses all methods capable of delivering each component of a therapy for treating or ameliorating a condition, composition, etc. to the target tissue, such as injection, injection, administration, infusion, ingestion, application, or the like.

[0051] According to an aspect, the administration can be performed once for the composition used in one medical treatment, or can be performed in multiple times. According to an aspect, the above composition can include a composition for injection, but is not limited thereto. For example, the above composition can be formulated as an injection, a suspension, or an external agent, etc.

[0052] According to an aspect, when the above composition is administered by injection, the administration method can be determined in consideration of the state of the administration subject, the area of the administration site, etc. The administration method can use linear injection, point injection, retrograde injection, cross grid injection, fan injection, micro-blunt needle injection, etc., linear injection is a method in which the composition is injected in a linear manner while slowly withdrawing the needle after inserting the injection needle, point injection is a method in which the composition is administered by being divided into a plurality of small points, retrograde injection is a method in which the needle is inserted deep, and the composition is injected while withdrawing the needle, cross grid injection is a method in which the composition is injected in a grid shape while linear injection is performed in a vertical and horizontal cross, fan injection is a method in which the composition is injected in a fan shape while moving in a plurality of directions after inserting the needle once, and micro-blunt needle injection is a method in which a blunt needle having a circular end is used instead of a needle to administer the composition, but the administration method is not limited thereto.

[0053] The above composition can have any one formulation selected from an injection (sterile aqueous solution), a suspension, and an external agent, and can be various formulations for non-oral administration.

[0054] When the above composition is formulated, a diluent or an excipient such as a filler, a thickening agent, a binder, a wetting agent, a disintegrant, a surfactant, etc. used in the art can be included. For example, when the above composition is formulated as an injection, an aqueous solvent such as physiological saline, a non-aqueous solvent such as a vegetable oil, a higher fatty acid ester, ethanol, benzyl alcohol, glycerol, etc. alcohol, etc. can be used. In addition, the above composition can further include a stabilizer such as ascorbic acid, EDTA, etc. for preventing deterioration of the formulation, an emulsifier, a cross-linking agent such as BDDE (1,4-butanediol diglycidyl ether), a buffer for adjusting pH, a preservative such as methylphenol, benzyl alcohol, etc. for controlling the growth of microorganisms (e.g., phenylmercuric nitrate, thiomersal, benzalkonium chloride, phenol, cresol, benzyl alcohol, etc.), and the like.

[0055] According to an aspect, the above injection can include hyaluronic acid or a pharmaceutically acceptable salt thereof, NaOH, BDDE, etc. As for the dose of the ingredients contained in the above injection except for the hyaluronic acid or the pharmaceutically acceptable salt thereof, the injection including the hyaluronic acid or the pharmaceutically acceptable salt thereof can be adjusted as appropriate according to the scheme known in the art.

[0056] According to an aspect, the concentration of the above hyaluronic acid or the pharmaceutically acceptable salt thereof can be 0.1 ~ 10% (1 mg / ml ~ 100 mg / ml), or 1 ~ 5% (10 mg / ml ~ 50 mg / ml), or 1 ~ 3% (10 mg / ml ~ 30 mg / ml), or 1.5 ~ 2.5% (15 mg / ml ~ 25 mg / ml).

[0057] According to an aspect, when the composition is formulated as a suspension, a vegetable oil such as propylene glycol, polyethylene glycol, an injectable ester such as ethyl oleate, etc. can be used.

[0058] In addition, according to an aspect, when the above composition is formulated as an external agent, it can be made in a solid, semi-solid, or liquid form by adding an inorganic or organic carrier, an excipient, and a diluent. For example, the above external agent can include a skin external agent having a transdermal administration preparation such as an ointment, a lotion, a gel, a cream, a patch, a spray, a suspension, and an emulsion, etc.

[0059] According to an aspect, when the viscosity of the above composition is as described above, the optimal diffusion force of the composition in the interdental papilla and the reconstruction effect of the interdental papilla can be shown. For example, when the viscosity of the composition exceeds the above range, it can be difficult to be applied in the interdental papilla due to the excessively high viscosity, and can show the limitation that it does not diffuse in the interdental papilla even after the application.

[0060] According to an aspect, the above composition application step can include a step of applying the composition in 0.005 ~ 0.05 cc.

[0061] According to an aspect, the amount of the composition applied in the composition application step described above can be 0.005 cc or more, or 0.006 cc or more, or 0.007 cc or more, or 0.008 cc or more, or 0.009 cc or more, or 0.01 cc or more, or 0.011 cc or more, or 0.013 cc or more, or 0.015 cc or more, or 0.017 cc or more, or 0.019 cc or more, or 0.02 cc or more, or 0.021 cc or more, or 0.022 cc or more, or 0.023 cc or more, or 0.024 cc or more, or 0.025 cc or more, or 0.026 cc or more, or 0.027 cc or more, or 0.028 cc or more, or 0.029 cc or more, or 0.03 cc or more, or 0.035 cc or more, or 0.040 cc or more, or 0.045 cc or more, or can be 0.05 cc or less, or 0.049 cc or less, or 0.047 cc or less, or 0.045 cc or less, or 0.043 cc or less, or 0.041 cc or less, or 0.040 cc or less, or 0.039 cc or less, or 0.037 cc or less, or 0.035 cc or less, or 0.033 cc or less, or 0.031 cc or less, or 0.030 cc or less, or 0.029 cc or less, or 0.028 cc or less, or 0.027 cc or less, or 0.026 cc or less, or 0.025 cc or less, or 0.024 cc or less, or 0.023 cc or less, or 0.022 cc or less, or 0.021 cc or less, or 0.020 cc or less, or 0.019 cc or less, or 0.017 cc or less, or 0.015 cc or less, or 0.013 cc or less, or 0.011 cc or less, or 0.010 cc or less, or 0.009 cc or less, or 0.008 cc or less, or 0.007 cc or less, or 0.006 cc or less.

[0062] According to an aspect, when the amount of the composition described above is less than the dosage described above, it is difficult to expect the papilla interdentalis reconstruction effect, and when the amount is excessive, side effects such as the generation of pain, the generation of a foreign body sensation due to the excessive increase in the volume of the papilla interdentalis portion, and the external outflow of the composition can occur.

[0063] According to an aspect, the composition application step described above can include a step of applying 1 to 10 times at 0.001 to 0.01 cc each time.

[0064] According to an aspect, the amount of the composition administered at one time (hereinafter, referred to as one dose) can be 0.001 to 0.01 cc, and according to an aspect, the amount of the composition administered at one time can be 0.001 cc or more, or 0.0015 cc or more, or 0.002 cc or more, or 0.0025 cc or more, or 0.003 cc or more, or 0.0035 cc or more, or 0.004 cc or more, or 0.0041 cc or more, or 0.0042 cc or more, or 0.0043 cc or more, or 0.0044 cc or more, or 0.0045 cc or more, or 0.0046 cc or more, or 0.0047 cc or more, or 0.0048 cc or more, or 0.0049 cc or more, or 0.005 cc or more, or 0.0055 cc or more, or 0.006 cc or more, or 0.0065 cc or more, or 0.007 cc or more, or 0.0075 cc or more, or 0.008 cc or more, or 0.0085 cc or more, or 0.009 cc or more, or 0.0095 cc or more, or can be 0.01 cc or less, or 0.009 cc or less, or 0.0085 cc or less, or 0.0080 cc or less, or 0.0075 cc or less, or 0.0070 cc or less, or 0.0065 cc or less, or 0.0060 cc or less, or 0.0059 cc or less, or 0.0058 cc or less, or 0.0057 cc or less, or 0.0056 cc or less, or 0.0055 cc or less, or 0.0054 cc or less, or 0.0053 cc or less, or 0.0052 cc or less, or 0.0051 cc or less, or 0.005 cc or less, or 0.0045 cc or less, or 0.0040 cc or less, or 0.0035 cc or less, or 0.0030 cc or less, or 0.0025 cc or less.

[0065] According to an aspect, the composition administration step described above can include a step of administering the composition 1 to 10 times when the composition is administered in the above one dose.

[0066] According to an aspect, the composition administration step described above can include a step of administering the composition 1 to 10 times when the composition is administered in the above one dose.

[0067] According to an aspect, in the composition administration step described above, when the one dose is 0.001 to 0.01 cc, the number of administrations can be 1 to 10 times, or 2 to 8 times, or 3 to 7 times, or 4 to 6 times.

[0068] Additionally, according to an aspect, in the composition applying step, the 1 dose can be 0.003 to 0.007 cc, in which case, the number of applications can be 3 to 7 times, or 4 to 6 times, or 5 times.

[0069] According to an aspect, the composition applying step can include the step of applying the composition to the gum of an area of 0.1 to 4 mm 2 in diameter.

[0070] According to an aspect, in the composition applying step, the area of the gum to which the composition is applied can be 0.01 mm 2 or more, or 0.05 mm 2 or more, or 0.1 mm 2 or more, or 0.15 mm 2 or more, or 0.20 mm 2 or more, or 0.25 mm 2 or more, or 0.30 mm 2 or more, or 0.35 mm 2 or more, or 0.40 mm 2 or more, or 0.45 mm 2 or more, or 0.50 mm 2 or more, or 0.55 mm 2 or more, or 0.60 mm 2 or more, or 0.65 mm 2 or more, or 0.70 mm 2 or more, or 0.75 mm 2 or more, or 0.80 mm 2 or more, or 0.81 mm 2 or more, or 0.83 mm 2 or more, or 0.85 mm 2 or more, or 0.87 mm 2 or more, or 0.89 mm 2 or more, or 0.90 mm 2 or more, or 0.91 mm 2 or more, or 0.92 mm 2 or more, or 0.93 mm 2 or more, or 0.94 mm 2 or more, or 0.95 mm 2 or more, or 0.96 mm 2 or more, or 0.97 mm 2 or more, or 0.98 mm 2 or more, or 0.99 mm 2 or more, or 1.0 mm 2 or more, or 1.5 mm 2 or more, or 2.0 mm2 Above, or 2.5mm 2 or above, or 3.0mm 2 or above, or 3.5mm 2 The above, or possibly 4.0mm 2 Below, or 3.5mm 2 Below or 3.0mm 2 Below, or 2.5mm 2 Below, or 2.0mm 2 Below, or 1.9mm 2 Below, or 1.8mm 2 Below, or 1.7mm 2 Below, or 1.6mm 2 Below, or 1.5mm 2 Below, or 1.47mm 2 Below, or 1.45mm 2 Below, or 1.43mm 2 Below, or 1.41mm 2 Below, or 1.4mm 2 Below, or 1.37mm 2 Below, or 1.35mm 2 Below, or 1.33mm 2 Below, or 1.31mm 2 Below, or 1.3mm 2 Below, or 1.27mm 2 Below, or 1.25mm 2 Below, or 1.23mm 2 Below, or 1.21mm 2 Below, or 1.2mm 2 Below, or 1.19mm 2 Below, or 1.17mm 2 Below, or 1.15mm 2 Below, or 1.13mm 2 Below, or 1.1mm 2 Below or 1.0mm 2 Below or 0.9mm 2 Below, or 0.8mm 2 Below, or 0.7mm 2 Below, or 0.6mm 2 Below, or 0.5mm 2 Below, or 0.4mm 2 Below, or 0.3mm 2 Below, or 0.2mm 2 Below, or 0.1mm 2 Below, or 0.09mm 2below, or 0.07 mm 2 below, or 0.05 mm 2 below, or 0.03 mm 2 below, or 0.02 mm 2 below.

[0071] According to an aspect, the area of the gingiva to which the above composition is applied can be 0.5 to 3.0 mm 2 , or 0.5 to 2.5 mm 2 , or 0.5 to 2.0 mm 2 , or 0.5 to 1.5 mm 2 , or 0.7 to 1.3 mm 2 , or 0.8 to 1.2 mm 2 .

[0072] According to an aspect, when the area of the gingiva to which the above composition is applied is within the above range, an excellent papilla reconstruction rate can be obtained.

[0073] According to an aspect, the above composition can include a gel formulation.

[0074] In addition, according to an aspect, in the above method, the papilla reconstruction rate, which is represented by the following mathematical formula 1, can be 70% or more.

[0075] [Mathematical Formula 1] Papilla reconstruction rate (%) = 100 x black triangle area after composition application / black triangle area before composition application.

[0076] (black triangle: a space in the shape of a black triangle between teeth due to loss or shedding of interdental papilla) According to an aspect, in the method of reconstructing the interdental papilla according to the present application, the papilla reconstruction rate can be 70% or more, or 71% or more, or 72% or more, or 73% or more, or 74% or more, or 75% or more, or 76% or more, or 77% or more, or 78% or more, or 79% or more, or 80% or more, or 85% or more, or 90% or more, or 95% or more.

[0077] In addition, according to an aspect, a step of applying the above composition using a needle of 25 to 35G can be included. According to an aspect, the above composition can be applied using a needle of 30G.

[0078] When the thickness of the needle of the syringe is as described above, the composition having the above viscosity can be easily applied while minimizing pain of the patient.

[0079] According to an aspect, the application of the above composition can be performed using a syringe equipped with an automatic syringe.

[0080] In addition, according to an aspect, the composition application step can include a step of applying the composition to a site 1 to 3 mm below the apex of the interdental papilla.

[0081] According to an aspect, the composition can be applied to a site 2 to 3 mm below the apex of the interdental papilla.

[0082] According to an aspect, the method can further include a shaping step.

[0083] According to an aspect, the shaping can refer to molding or adjusting the portion to which the composition is applied using a hand or an instrument, etc.

[0084] According to an aspect, the shaping step can be performed after the application step.

[0085] According to an aspect, the shaping can be adjusted so that the composition applied is appropriately positioned at the target application site. For example, the shaping can correct the composition applied to be lumped or protruded in the application site, or can be uniformly distributed in the application site and form a natural gum line.

[0086] According to an aspect, an embodiment of the shaping can be represented by massage. The massage can refer to massage performed by gently applying pressure, etc. using a hand, etc. in order to naturally position the composition injected into the application site in the application site. According to an aspect, the composition can be flattened or stretched in the application site by the massage.

[0087] In addition, according to an aspect, the method of reconstructing the interdental papilla can be performed at intervals of 2 to 4 weeks.

[0088] In addition, the method of reconstructing the interdental papilla can further include behaviors for reconstructing the interdental papilla or dental treatment that are generally known to those skilled in the art. For example, oral disinfection, anesthesia, hot compress, massage, etc. can be included.

[0089] In addition, the present application is a kit for reconstructing an interdental papilla, including a composition containing hyaluronic acid or a pharmaceutically acceptable salt thereof, and a medical treatment manual describing a method of reconstructing an interdental papilla.

[0090] In the above description, contents regarding the plural viscosity of the composition containing hyaluronic acid or a pharmaceutically acceptable salt thereof, the application unit area, the one-time dose, the number of applications, other matters, etc. can be described.

[0091] According to an aspect, the composition containing hyaluronic acid or a pharmaceutically acceptable salt thereof in the above-described kit can be filled in a container or a vessel. According to an aspect, the above-described hyaluronic acid or a pharmaceutically acceptable salt thereof can be filled in a solid form (e.g., a lyophilized powder) or a liquid form, but is not limited thereto.

[0092] According to an aspect, the above-described composition can be filled in a vessel according to the ingredients contained in the composition. In the above-described kit, in addition to the composition, an anesthetic, an anti-inflammatory agent, a pH adjusting agent, etc. can be contained. These can be separately filled in a vessel different from the vessel filled with the composition.

[0093] In addition, based on the above-described content, the above-described composition can be used as a medicament in the reconstruction of the interdental papilla.

[0094] In addition, the above-described kit can include an administration device for delivering the composition to an administration site. According to an aspect, the above-described administration device can be an injection solution, but is not limited thereto.

[0095] Hereinafter, the present application will be specifically described through examples. These examples are only for exemplifying the present application, and the scope of the present application is not limited to these examples.

[0096] [Experimental Example 1] Confirmation of interdental papilla reconstruction rate according to complex viscosity of hyaluronic acid gel After the hyaluronic acid gel described in Table 1 was administered to a 2-3 mm site of the interdental papilla tip of the subject in an amount of 0.005 cc per time using a 30G needle equipped with an automatic syringe (syringe) 5 times (0.025 cc in total), the interdental papilla reconstruction rate over time was confirmed.

[0097] Table 1

[0098] As a result, in test Nos. 1 to 6, the interdental papilla reconstruction rate was proportionally increased with the time elapsed after administration. In addition, it was confirmed that in test Nos. 1 to 6, the interdental papilla reconstruction rate was proportionally increased with the complex viscosity (see Figure 1 ).

[0099] On the other hand, when the complex viscosity exceeds 700 as in test No. 7, it is difficult to administer into the interdental papilla due to the excessively high complex viscosity, and is not suitable for interdental papilla reconstruction.

[0100] [Experimental Example 2] Confirmation of interdental papilla reconstruction rate according to dose of hyaluronic acid gel Test No. 6 showing the most excellent interdental papilla reconstruction rate in Experimental Example 1 was injected into the interdental papilla tip using a syringe equipped with a 30G needle.

[0101] To confirm the interdental papilla reconstruction rate according to the dose of the hyaluronic acid gel, the total dose was set to 0.005 cc, 0.01 cc, 0.025 cc, 0.05 cc, 0.1 cc, 0.2 cc, and was administered in 5 times, respectively (for example, in the case of the total dose of 0.005 cc, 0.001 cc was administered in 5 times, respectively).

[0102] As a result, it was confirmed that the interdental papilla reconstruction rate increased in proportion to the total dose. In addition, when the total dose exceeded 0.025 cc, the increase in the interdental papilla reconstruction rate was not significant, and there was a risk of increasing side effects (see Figure 2 ).

[0103] As a result, it was confirmed that the interdental papilla reconstruction rate increased in proportion to the total dose. In addition, when the total dose exceeded 0.025 cc, the increase in the interdental papilla reconstruction rate was not significant, and there was a risk of increasing side effects (see

[0104] [Experimental Example 3] Confirmation of the interdental papilla reconstruction rate (%) according to 1 dose per unit area of administration The administration area of the hyaluronic acid gel was set to 0.25 mm 2 , 1.0 mm 2 , 4.0 mm 2 , 9.0 mm 2 , and the dose of each area was set to 0.001 cc, 0.002 cc, 0.005 cc, and was administered 5 times using a syringe equipped with a 30G needle of an automatic syringe. Figure 3 The injection point (the point of administration) can be confirmed in the center.

[0105] As a result, as shown in Table 2 below, when 1 dose per unit area of administration was 0.005 cc, the most excellent interdental papilla reconstruction rate could be confirmed. In addition, when the administration area was 1 mm 2 , it was confirmed that the interdental papilla reconstruction rate was most improved.

[0106] Table 2

[0107] The above has been described centering on the embodiment, but this is only an example, and the present application is not limited thereto, and a person having ordinary skill in the art to which the present application pertains should be able to make various modifications and applications not exemplified above within the scope of the essence of the present embodiment. For example, each of the constituent elements specifically shown in the embodiment can be modified. Also, the differences related to such modifications and applications should be interpreted as being within the scope of the present application defined in the appended claims.

Claims

1. A method for reconstruction of interdental papilla, wherein, the method comprises an administration step of administering to the gingiva a composition comprising hyaluronic acid or a pharmaceutically acceptable salt of the hyaluronic acid, the composition comprises a composition having a complex viscosity of 200 to 850 Pa.s.

2. The method for reconstruction of interdental papilla according to claim 1, wherein, the administration step comprises administration of 0.005 to 0.05 cc of the composition.

3. The method for reconstruction of interdental papilla according to claim 1, wherein, the administration step comprises administration of the composition 1 to 10 times at 0.001 to 0.01 cc each time.

4. The method for reconstruction of interdental papilla according to claim 1, wherein, The administering step comprises administering the composition to the gingiva in an area of 0.1 to 4 mm 2 area.

5. The method for reconstruction of interdental papilla according to claim 1, wherein, the composition comprises a gel preparation.

6. The method for reconstruction of interdental papilla according to claim 1, wherein, the rate of reconstruction of the interdental papilla of the method is 70% or more as represented by the following mathematical formula 1, [mathematical formula 1] Rate of reconstruction of interdental papilla (%) = 100 x area of black triangle after administration of the composition / area of black triangle before administration of the composition.

7. The method for reconstruction of interdental papilla according to claim 1, wherein, the administration of the composition comprises administration using a needle of 25 to 35 G.

8. The method for reconstruction of interdental papilla according to claim 1, wherein, the administration step comprises administration of the composition to a position 1 to 3 mm below the tip of the interdental papilla.

9. The method for reconstruction of interdental papilla according to claim 1, wherein, the method further comprises a shaping step.

10. The method for reconstruction of interdental papilla according to claim 1, wherein, the method comprises performance at intervals of 2 to 4 weeks.

11. A kit for reconstruction of interdental papilla, comprising: a composition comprising hyaluronic acid or a pharmaceutically acceptable salt of the hyaluronic acid; and a medical treatment manual describing the method for reconstruction of interdental papilla according to any one of claims 1 to 10.

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