Low surface friction organic pullulan hollow capsule and method for preparing the same

Abstract

The application discloses a kind of low surface friction organic pullulan hollow capsules and preparation method thereof, it is related to the technical field of medicinal materials and capsule manufacturing. By dispersing organic pullulan, potassium chloride, organic glycerol into purified water;Then, gelling agent, composite lubricant are sequentially added, stirring dispersion;Finally, process into hollow capsule finished product. Among them, gelling agent is obtained by mixing and preparing organic gelling material, purified water with mass ratio (0.5~5):(50~100);Composite lubricant is obtained by mixing and preparing organic starch, lubricating aid, purified water with mass ratio (0.4~3.2):(0.1~0.8):(2~16);Composite lubricant also includes organic lecithin, the amount is 4~8wt% of the amount of organic starch added. The application comprehensively prepares a kind of organic pullulan hollow capsules with low surface friction, antistatic, high on-machine qualified rate.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical excipients and capsule manufacturing technology, specifically to a low-surface-friction organic pullulan polysaccharide empty capsule and its preparation method. Background Technology

[0002] Organic pullulan is a water-soluble polysaccharide produced by fermentation of budding short stem enzymes. It has good film-forming properties, edibility, and transparency, and is widely used in the production of plant-based capsules.

[0003] With the development of the organic market, organic pullulan empty capsules are gradually replacing traditional chemically additive-based capsules. However, due to NOP standards, these capsules are prohibited from using synthetic lubricants and surfactants such as SLS (sodium lauryl sulfate), Tween 80, and PEG. This results in a surface friction of up to 4.5N on the capsule, which easily leads to static electricity buildup and particulate dust adsorption, causing problems such as sluggish operation of automatic filling machines, capsule jamming, denting, and splitting, ultimately affecting the final pass rate.

[0004] Therefore, there is an urgent need to develop an organic pullulan polysaccharide empty capsule that meets NOP standards and has low surface friction and antistatic properties, in order to improve the smoothness of capsule filling and thus increase the pass rate of capsules on the machine. This is of great significance for enhancing the application value of organic pullulan polysaccharide empty capsules. Summary of the Invention

[0005] The purpose of this invention is to provide a low-surface-friction organic pullulan polysaccharide empty capsule and its preparation method, so as to solve the problems mentioned in the background art.

[0006] To solve the above-mentioned technical problems, the present invention provides the following technical solution:

[0007] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules includes the following steps:

[0008] S1: Add organic pullulan polysaccharide, potassium chloride, and organic glycerol to purified water, stir and disperse at 1000~2000 rpm for 2~10 minutes, then preheat to 45~60℃ for later use;

[0009] S2: Mix organic gelling materials and purified water to prepare a gelling agent; then add the gelling agent to S1 and stir and disperse at a stirring speed of 300~500 rpm for 5~15 minutes.

[0010] S3: Mix organic starch, lubricant, and purified water to prepare a composite lubricant; then add the composite lubricant to S2 and stir and disperse at a stirring speed of 300~500 rpm for 5~15 minutes to obtain a mixed adhesive solution.

[0011] S4: After the mixed glue solution is degassed, it is filtered through a 200-300 mesh sieve. Then, it is processed and shaped by dipping or molding. After drying, cutting and fitting, the empty capsule product is obtained, namely, low surface friction organic pullulan polysaccharide empty capsule.

[0012] Furthermore, the preparation of the low-surface-friction organic pullulan polysaccharide empty capsules comprises the following raw material components in parts by weight: 100 parts organic pullulan polysaccharide, 0.1-1 parts potassium chloride, 0.05-1 parts organic glycerin, 0.5-5 parts organic gelling material, 0.4-3.2 parts organic starch, 0.1-0.8 parts lubricant, and 252-616 parts purified water.

[0013] Furthermore, the gelling agent is prepared by mixing organic gelling materials and purified water at a mass ratio of (0.5~5):(50~100); the preparation method is as follows:

[0014] (1) Add different organic gelling materials separately to purified water at 45~60℃ and stir and disperse at a stirring speed of 50~150rpm for 10~20min to completely dissolve the organic gelling materials;

[0015] (2) Mix the solutions of different organic gelling materials and stir and disperse them at a stirring speed of 100~300rpm for 10~20min to obtain gelling agent, and keep it warm for later use.

[0016] Furthermore, the composite lubricant is prepared by mixing organic starch, lubricating aid, and purified water in a mass ratio of (0.4~3.2):(0.1~0.8):(2~16); the preparation method is as follows:

[0017] (1) Add organic starch to purified water and stir at 300-500 rpm for 5-15 min to obtain organic starch suspension;

[0018] (2) Stir the organic starch suspension at a stirring speed of 500-800 rpm and heat it to 70-80°C, then continue to keep it warm and stir for 30-60 minutes;

[0019] (3) Add the lubricating agent to purified water at 70~80℃ and stir and disperse at a stirring speed of 300~500rpm for 5~15min to obtain a lubricating agent suspension;

[0020] (4) Add lubricant suspension to (2), stir and disperse at a stirring speed of 300~500rpm for 5~15min, then cool down to 45~60℃ to obtain composite lubricant, keep warm for later use.

[0021] Furthermore, the organic gelling material includes, but is not limited to, one or more combinations of organic guar gum, organic gum arabic, and organic locust bean gum.

[0022] Furthermore, the organic cementitious material is obtained by mixing and compounding organic guar gum and organic gum arabic in a mass ratio of (6~9):(1~4).

[0023] Furthermore, the organic cementitious material is obtained by mixing and compounding organic guar gum and organic gum arabic in a mass ratio of (7~8):(2~3).

[0024] Furthermore, the organic starch includes, but is not limited to, one or more combinations of organic cassava starch, organic rice starch, organic corn starch, organic pea starch, organic wheat starch, and organic potato starch.

[0025] Furthermore, the organic starch is obtained by mixing organic cassava starch and organic rice starch in a mass ratio of (2~4):(1~2).

[0026] Furthermore, the organic starch is obtained by mixing organic tapioca starch and organic rice starch in a mass ratio of 3:1.

[0027] Furthermore, the lubricating agent includes, but is not limited to, one or more combinations of silica, stearic acid, magnesium stearate, kaolin, carnauba wax, beeswax, and candelilla wax.

[0028] Furthermore, the composite lubricant also includes organic lecithin, the amount of which is 4-8 wt% of the amount of organic starch added; the method of introducing organic lecithin is as follows: in the preparation step (3) of the composite lubricant, the lubricating agent and organic lecithin are added to purified water at 70-80℃ and stirred and dispersed at a stirring speed of 300-500 rpm for 5-15 minutes to obtain a lubricating agent-organic lecithin suspension; other steps remain unchanged.

[0029] Furthermore, the process parameters for the degassing treatment are: vacuum degree of -0.08 to -0.095 MPa, and duration of 10 to 30 min.

[0030] Furthermore, the present invention also provides a low-surface-friction organic pullulan polysaccharide empty capsule, which is prepared by the above preparation method.

[0031] Compared with the prior art, the beneficial effects achieved by the present invention are:

[0032] (1) In this invention, organic pullulan is subjected to low-temperature dispersion and homogenization treatment, followed by heating to promote its dissolution. This method can effectively reduce the hydrolysis reaction of organic pullulan during the dissolution process and avoid the aggregation phenomenon caused by direct high-temperature dissolution. This unique sol treatment method brings significant advantages to the application of organic pullulan. During the low-temperature dispersion and homogenization stage, organic pullulan molecules can be uniformly distributed in the solvent system, maintaining a relatively independent state, which creates good conditions for subsequent heating and dissolution. As the temperature gradually increases, the organic pullulan molecules that have undergone the pretreatment can interact with the solvent molecules more orderly, achieving stable and efficient dissolution. By reducing the hydrolysis reaction and avoiding aggregation, the quality and performance of the organic pullulan solution are greatly improved, thereby improving the quality and performance of the prepared hollow capsules.

[0033] (2) This invention uses organic gelling materials to enhance the strength and toughness of capsules. These materials have good compatibility with organic pullulan, and with adjustments to process parameters, the capsule wall thickness can be made uniform, the shape regular, and quality defects such as splitting and denting can be reduced. Since the organic pullulan undergoes low-temperature dispersion and homogenization in this invention, and is subsequently stored at 45-60℃ for later use, this temperature is relatively low. To adapt to this temperature, the organic gelling material used as the gelling agent should have good low-temperature solubility. Simultaneously, considering the stability of capsule forming and surface lubrication, the organic gelling material needs to have high viscosity and good emulsifying properties. Based on this, this invention specifically uses a mixture of organic guar gum and organic gum arabic to form the organic gelling material. Organic guar gum and organic gum arabic have relatively good low-temperature solubility; furthermore, organic guar gum provides high viscosity, and organic gum arabic provides certain emulsifying properties. The synergy of these two materials allows the capsules to achieve optimal performance.

[0034] (3) In the final composite lubricant of this invention, high-branched starch—organic cassava starch and high-linear starch—organic rice starch are selected as the raw materials to form organic starch. The reason is that: in the lubrication system, the high branching of organic cassava starch has strong intermolecular entanglement ability, which can provide "strong winding", ensuring the flexibility and continuity of the membrane material; the high linear chain and fine particle size of organic rice starch, the linear molecules can fill the pores, which can provide "density", reducing the internal pores and surface granularity of the membrane material; after the two are combined, the linear chain of organic rice starch can be cross-linked by hydrogen bonds, and through linear filling, it intersects with the branched network of organic cassava starch to form a "continuous and dense membrane material skeleton", which significantly improves the mechanical strength and structural stability of the membrane material, thereby ensuring that the capsule does not crack or break during the capsule forming process, that is, improving the forming stability of the capsule.

[0035] (4) A lubricating agent is added to the composite lubricant. The inert nature of the lubricating agent will not affect the film-forming mechanism of organic starch. It only optimizes the surface through physical action and will not damage the overall performance of the capsule. The lubricating agent can work with organic starch to improve the surface roughness of the capsule. At the same time, the lubricating agent can also improve the anti-sticking property of the film material and prevent the capsule from sticking together.

[0036] (5) Organic lecithin was further added to the composite lubricant. The reasons are as follows: First, organic lecithin is an amphoteric substance that can form an interfacial film between raw material components and between capsules, thereby playing a role in synergistically enhancing the anti-sticking properties of the lubricant. Second, organic lecithin has an emulsifying and dispersing effect, which can promote the dispersion of organic starch and lubricant, thereby enhancing the effect of the composite lubricant in the capsule. Third, organic lecithin has an antistatic effect, which can improve the antistatic properties of the capsule, thereby reducing the adsorption of particulate dust on the capsule surface and improving the pass rate of the machine.

[0037] (6) In the composite lubricant, the effect of “1+1+1+1>4” is finally achieved through the synergistic effect of organic starch compounding + synergistic effect of lubricating additives + synergistic effect of organic lecithin. The resulting capsules are not only stable in shape, but also have the advantages of low surface friction, antistatic properties and high machine pass rate.

[0038] In summary, this invention, through improvements in three aspects—the treatment of organic pullulan, the selection of gelling agent formulation, and the selection of composite lubricant formulation—has comprehensively prepared an organic pullulan empty capsule that combines low surface friction, antistatic properties, and a high machine pass rate, which has significant practical application value. Attached Figure Description

[0039] Figure 1 The image shows the actual product obtained by filling the organic pullulan polysaccharide hollow capsules prepared in Example 17. Detailed Implementation

[0040] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0041] It should be noted that the following quantities are by weight, and there are no special restrictions on the suppliers of all raw materials involved in this invention. Exemplary examples include:

[0042] In the following examples, organic pullulan (99% purity), organic guar gum (catalog number 9000-30-0, 99% purity), organic lecithin (99.5% purity), silica (99% purity, particle size 15-100 nm), organic tapioca starch (99% purity), organic rice starch (99% purity), and organic gum arabic (99% purity) were all purchased from Earth Supplied Products. All other ingredients were commercially available. Each serving is 100g.

[0043] Example 1: A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0044] S1: Add 100 parts organic pullulan polysaccharide, 0.5 parts potassium chloride, and 0.1 parts organic glycerol to 400 parts purified water, stir and disperse at 1500 rpm for 5 minutes, then preheat to 50°C and set aside.

[0045] S2: Mix organic gelling materials and purified water to prepare a gelling agent; then add the gelling agent to S1 and stir to disperse;

[0046] S21: Preparation of gelling agent: Disperse 4 parts of organic guar gum into 50 parts of purified water at 50°C, stir at 100 rpm for 15 minutes to completely dissolve the organic gelling material, and then stir at 200 rpm for 15 minutes to obtain the gelling agent, and keep it warm for later use.

[0047] S22: Add the gelling agent prepared in S21 to the mixed solution obtained in S1, and stir and disperse at a stirring speed of 400 rpm for 10 min;

[0048] S3: Mix organic starch, lubricant, and purified water to prepare a composite lubricant; then add the composite lubricant to S2, stir and disperse to obtain a mixed adhesive solution;

[0049] S31: Preparation of composite lubricant: (1) Add 1.6 parts of organic cassava starch to 8 parts of purified water and stir at 400 rpm for 10 min to obtain an organic starch suspension; (2) Stir the organic starch suspension at 650 rpm and heat it to 75°C, then continue to stir and keep it warm for 45 min; (3) Add 0.4 parts of silica to purified water at 75°C and stir and disperse at 400 rpm for 10 min to obtain a silica suspension; (4) Add silica suspension to (2), stir and disperse at 400 rpm for 10 min, then cool it down to 50°C to obtain a composite lubricant, and keep it warm for later use;

[0050] S32: Add the composite lubricant prepared in S31 to the mixed solution obtained in S2, and stir and disperse at a stirring speed of 400 rpm for 10 min to obtain a mixed adhesive solution.

[0051] S4: After the mixed adhesive solution is degassed (vacuum degree is -0.085MPa, duration is 30min), it is filtered through a 250-mesh sieve. Then, it is made into hollow capsules by dipping the adhesive. After drying, cutting and fitting, 0# specification hollow capsules are obtained.

[0052] The following is based on Example 1, with Examples 2 to 7 set up as follows:

[0053] Example 2: Example 2 is based on Example 1, but with the following adjustment: the amount of organic guar gum is changed from 4 parts to 0.5 parts, while other processes remain unchanged. Specifically:

[0054] S21: Preparation of gelling agent: Disperse 0.5 parts of organic guar gum into 50 parts of purified water at 50°C, stir at 100 rpm for 15 minutes to completely dissolve the organic gelling material, and then stir at 200 rpm for 15 minutes to obtain the gelling agent, and keep it warm for later use.

[0055] Example 3: Example 3 is based on Example 1, but with the following adjustment: the amount of organic guar gum is increased from 4 parts to 5 parts, while other processes remain unchanged. Specifically:

[0056] S21: Preparation of gelling agent: Disperse 5 parts of organic guar gum into 50 parts of purified water at 50°C, stir at 100 rpm for 15 minutes to completely dissolve the organic gelling material, and then stir at 200 rpm for 15 minutes to obtain the gelling agent, and keep it warm for later use.

[0057] Example 4: Example 4 is based on Example 1, with the following adjustment: organic guar gum is replaced with organic gum arabic, while other processes remain unchanged. Specifically:

[0058] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0059] S21: Preparation of gelling agent: Disperse 4 parts of organic gum arabic into 50 parts of purified water at 50°C, stir at 100 rpm for 15 minutes to completely dissolve the organic gelling material, and then stir at 200 rpm for 15 minutes to obtain the gelling agent, and keep it warm for later use.

[0060] Example 5: Example 5 is based on Example 1, with the following adjustment: the organic cementitious material is a mixture of organic guar gum and organic gum arabic in a ratio of 6:4, while other processes remain unchanged. Specifically:

[0061] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0062] S21: Preparation of gelling agent: Disperse 2.4 parts of organic guar gum and 1.6 parts of organic gum arabic (in a ratio of 6:4) into 25 parts of purified water at 50°C and stir at 100 rpm for 15 min to completely dissolve the organic gelling material; (2) Mix the organic guar gum solution and the organic gum arabic solution and stir at 200 rpm for 15 min to obtain the gelling agent, and keep it warm for later use.

[0063] Example 6: Example 6 is based on Example 1, with the following adjustment: the organic cementitious material is a mixture of organic guar gum and organic gum arabic in a ratio of 7:3, while other processes remain unchanged. Specifically:

[0064] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0065] S21: Preparation of gelling agent: Disperse 2.8 parts of organic guar gum and 1.2 parts of organic gum arabic (in a ratio of 7:3) into 25 parts of purified water at 50°C and stir at 100 rpm for 15 min to completely dissolve the organic gelling material; (2) Mix the organic guar gum solution and the organic gum arabic solution and stir at 200 rpm for 15 min to obtain the gelling agent, and keep it warm for later use.

[0066] Example 7: Example 7 is based on Example 1, with the following adjustment: the organic cementitious material is a mixture of organic guar gum and organic gum arabic in a ratio of 8:2, while other processes remain unchanged. Specifically:

[0067] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0068] S21: Preparation of gelling agent: Disperse 3.2 parts of organic guar gum and 0.8 parts of organic gum arabic (in a ratio of 8:2) into 25 parts of purified water at 50°C and stir at 100 rpm for 15 min to completely dissolve the organic gelling material; (2) Mix the organic guar gum solution and the organic gum arabic solution and stir at 200 rpm for 15 min to obtain the gelling agent, and keep it warm for later use.

[0069] Example 8: Example 8 is based on Example 1, with the following adjustments: the organic cementitious material is a blend of organic guar gum and organic gum arabic in a ratio of 9:1, while other processes remain unchanged. Specifically:

[0070] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0071] S21: Preparation of gelling agent: Disperse 3.6 parts of organic guar gum and 0.4 parts of organic gum arabic (in a ratio of 9:1) into 25 parts of purified water at 50°C and stir at 100 rpm for 15 min to completely dissolve the organic gelling material; (2) Mix the organic guar gum solution and the organic gum arabic solution and stir at 200 rpm for 15 min to obtain the gelling agent, and keep it warm for later use.

[0072] Performance Test 1: The hollow capsules prepared in Examples 1-8 were subjected to surface friction force testing and yield testing. The specific testing methods are as follows:

[0073] (1) The surface friction force of the capsule is measured using the method in CN108548478A "A Quantification Method for Surface Smoothness of Capsules", wherein the magnitude of the tensile force is specified.

[0074] (2) The capsules corresponding to each example were filled by an automatic capsule filling machine, and then 1,000 capsules were taken from each set of examples for the pass rate test.

[0075] The specific test results are shown in Table 1:

[0076]

[0077] Conclusion: As shown in Table 1, the test results of Examples 5-8 are significantly better than those of Examples 1-4, indicating that the capsules prepared using a blend of organic guar gum and organic gum arabic as organic gelling materials have better performance, demonstrating the necessity and importance of this blend. Examples 6 and 7 show even better performance than the other examples. Example 6 is slightly better than Example 7, meaning Example 6 exhibits the best performance.

[0078] The following is based on Example 6, with Examples 9 to 16 set up as follows:

[0079] Example 9: Example 9 is based on Example 6, but the ratio of organic cassava starch, silica, and purified water is adjusted from 1.6:0.4:8 to 0.4:0.1:2, while other processes remain unchanged. Specifically:

[0080] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0081] S31: Preparation of composite lubricant: (1) Add 0.4 parts of organic cassava starch to 2 parts of purified water and stir at 400 rpm for 10 min to obtain an organic starch suspension; (2) Stir the organic starch suspension at 650 rpm and heat it to 75°C, then continue to stir and keep it warm for 45 min; (3) Add 0.1 parts of silica to purified water at 75°C and stir and disperse at 400 rpm for 10 min to obtain a silica suspension; (4) Add silica suspension to (2), stir and disperse at 400 rpm for 10 min, then cool it down to 50°C to obtain a composite lubricant, and keep it warm for later use.

[0082] Example 10: Example 10 is based on Example 6, but the ratio of organic cassava starch, silica, and purified water is adjusted from 1.6:0.4:8 to 3.2:0.8:16. Other processes remain unchanged. Specifically:

[0083] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0084] S31: Preparation of composite lubricant: (1) Add 3.2 parts of organic cassava starch to 16 parts of purified water and stir at 400 rpm for 10 min to obtain an organic starch suspension; (2) Stir the organic starch suspension at 650 rpm and heat it to 75°C, then continue to stir and keep it warm for 45 min; (3) Add 0.8 parts of silica to purified water at 75°C and stir and disperse at 400 rpm for 10 min to obtain a silica suspension; (4) Add silica suspension to (2), stir and disperse at 400 rpm for 10 min, then cool it down to 50°C to obtain a composite lubricant, and keep it warm for later use.

[0085] Example 11: Example 11 is based on Example 6, with the following adjustment: organic cassava starch is replaced with organic rice starch, while other processes remain unchanged. Specifically:

[0086] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0087] S31: Preparation of composite lubricant: (1) Add 1.6 parts of organic rice starch to 8 parts of purified water and stir at 400 rpm for 10 min to obtain an organic starch suspension; (2) Stir the organic starch suspension at 650 rpm and heat it to 75°C, then continue to stir and keep it warm for 45 min; (3) Add 0.4 parts of silica to purified water at 75°C and stir and disperse at 400 rpm for 10 min to obtain a silica suspension; (4) Add silica suspension to (2), stir and disperse at 400 rpm for 10 min, then cool it down to 50°C to obtain a composite lubricant, and keep it warm for later use;

[0088] Example 12: Example 12 is based on Example 6, with the following adjustment: the organic starch is a blend of organic tapioca starch and organic rice starch in a 2:1 ratio, while other processes remain unchanged. Specifically:

[0089] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0090] S31: Preparation of composite lubricant: (1) Add 1.066 parts organic cassava starch and 0.533 parts organic rice starch (ratio 2:1) to 8 parts purified water and stir at 400 rpm for 10 min to obtain organic starch suspension; (2) Stir the organic starch suspension at 650 rpm and heat it to 75°C, then continue to keep it warm and stir for 45 min; (3) Add 0.4 parts silica to purified water at 75°C and stir at 400 rpm for 10 min to obtain silica suspension; (4) Add silica suspension to (2), stir at 400 rpm for 10 min, then cool to 50°C to obtain composite lubricant, and keep it warm for later use.

[0091] Example 13: Example 13 is based on Example 6, with the following adjustment: the organic starch is a blend of organic tapioca starch and organic rice starch in a 3:1 ratio, while other processes remain unchanged. Specifically:

[0092] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0093] S31: Preparation of composite lubricant: (1) Add 1.2 parts organic cassava starch and 0.4 parts organic rice starch (in a ratio of 3:1) to 8 parts purified water and stir at 400 rpm for 10 min to obtain an organic starch suspension; (2) Stir the organic starch suspension at 650 rpm and heat it to 75°C, then continue to keep it warm and stir for 45 min; (3) Add 0.4 parts silica to purified water at 75°C and stir at 400 rpm for 10 min to obtain a silica suspension; (4) Add silica suspension to (2), stir at 400 rpm for 10 min, then cool it to 50°C to obtain a composite lubricant, and keep it warm for later use.

[0094] Example 14: Example 14 is based on Example 6, with the following adjustment: the organic starch is a blend of organic tapioca starch and organic rice starch in a ratio of 4:1, while other processes remain unchanged. Specifically:

[0095] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0096] S31: Preparation of composite lubricant: (1) Add 1.28 parts organic cassava starch and 0.32 parts organic rice starch (in a ratio of 4:1) to 8 parts purified water and stir at 400 rpm for 10 min to obtain an organic starch suspension; (2) Stir the organic starch suspension at 650 rpm and heat it to 75°C, then continue to keep it warm and stir for 45 min; (3) Add 0.4 parts silica to purified water at 75°C and stir at 400 rpm for 10 min to obtain a silica suspension; (4) Add silica suspension to (2), stir at 400 rpm for 10 min, then cool it to 50°C to obtain a composite lubricant, and keep it warm for later use.

[0097] Example 15: Example 15 is based on Example 6, with the following adjustment: the organic starch is a blend of organic tapioca starch and organic rice starch in a 1:1 ratio, while other processes remain unchanged. Specifically:

[0098] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0099] S31: Preparation of composite lubricant: (1) Add 0.6 parts organic cassava starch and 0.6 parts organic rice starch (in a ratio of 1:1) to 8 parts purified water and stir at 400 rpm for 10 min to obtain an organic starch suspension; (2) Stir the organic starch suspension at 650 rpm and heat it to 75°C, then continue to keep it warm and stir for 45 min; (3) Add 0.4 parts silica to purified water at 75°C and stir at 400 rpm for 10 min to obtain a silica suspension; (4) Add silica suspension to (2), stir at 400 rpm for 10 min, then cool it to 50°C to obtain a composite lubricant, and keep it warm for later use.

[0100] Example 16: Example 16 is based on Example 6, with the following adjustment: the organic starch is a blend of organic tapioca starch and organic rice starch in a 3:2 ratio, while other processes remain unchanged. Specifically:

[0101] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0102] S31: Preparation of composite lubricant: (1) Add 0.96 parts organic cassava starch and 0.64 parts organic rice starch (in a ratio of 3:2) to 8 parts purified water and stir at 400 rpm for 10 min to obtain an organic starch suspension; (2) Stir the organic starch suspension at 650 rpm and heat it to 75°C, then continue to keep it warm and stir for 45 min; (3) Add 0.4 parts silica to purified water at 75°C and stir at 400 rpm for 10 min to obtain a silica suspension; (4) Add silica suspension to (2), stir at 400 rpm for 10 min, then cool it down to 50°C to obtain a composite lubricant, and keep it warm for later use.

[0103] Performance Test 2: The hollow capsules prepared in Examples 9-16 were subjected to surface friction force testing and pass rate testing using the above testing methods. The specific test results are shown in Table 2.

[0104]

[0105] Conclusion: As can be seen from the results in Table 2 above, the test results of Examples 12-16 are significantly better than those of Examples 6 and 9-11, indicating that the capsules prepared by using a compound of organic cassava starch and organic rice starch as the components of the composite lubricant have better performance, demonstrating the necessity and importance of the compounding of organic cassava starch and organic rice starch. The performance test results of Example 13 are particularly superior to those of the other examples.

[0106] The following is based on Example 13, with Examples 17-19 set up as follows:

[0107] Example 17: Example 17 is based on Example 13, with the following adjustment: organic lecithin is further introduced, with the amount added being 6 wt% of the amount of organic starch added, while other processes remain unchanged. Specifically:

[0108] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0109] S31: Preparation of composite lubricant: (1) Add 1.2 parts organic cassava starch and 0.4 parts organic rice starch (in a ratio of 3:1) to 8 parts purified water and stir at 400 rpm for 10 min to obtain an organic starch suspension; (2) Stir the organic starch suspension at 650 rpm and heat it to 75°C, then continue to keep it warm and stir for 45 min; (3) Add 0.4 parts silica and 0.096 parts organic lecithin to purified water at 75°C and stir at 400 rpm for 10 min to obtain a silica-organic lecithin suspension; (4) Add the silica-organic lecithin suspension to (2), stir at 400 rpm for 10 min, then cool it to 50°C to obtain a composite lubricant, and keep it warm for later use.

[0110] Example 18: Example 18 is based on Example 13, with the following adjustment: organic lecithin is further introduced, with the amount added being 4 wt% of the amount of organic starch added, while other processes remain unchanged. Specifically:

[0111] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0112] S31: Preparation of composite lubricant: (1) Add 1.2 parts organic cassava starch and 0.4 parts organic rice starch (in a ratio of 3:1) to 8 parts purified water and stir at 400 rpm for 10 min to obtain an organic starch suspension; (2) Stir the organic starch suspension at 650 rpm and heat it to 75°C, then continue to keep it warm and stir for 45 min; (3) Add 0.4 parts silica and 0.064 parts organic lecithin to purified water at 75°C and stir at 400 rpm for 10 min to obtain a silica-organic lecithin suspension; (4) Add the silica-organic lecithin suspension to (2), stir at 400 rpm for 10 min, then cool it to 50°C to obtain a composite lubricant, and keep it warm for later use.

[0113] Example 19: Example 19 is based on Example 13, with the following adjustment: organic lecithin is further introduced, with the amount added being 8 wt% of the amount of organic starch added, while other processes remain unchanged. Specifically:

[0114] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0115] S31: Preparation of composite lubricant: (1) Add 1.2 parts organic cassava starch and 0.4 parts organic rice starch (in a ratio of 3:1) to 8 parts purified water and stir at 400 rpm for 10 min to obtain an organic starch suspension; (2) Stir the organic starch suspension at 650 rpm and heat it to 75°C, then continue to keep it warm and stir for 45 min; (3) Add 0.4 parts silica and 0.128 parts organic lecithin to purified water at 75°C and stir at 400 rpm for 10 min to obtain a silica-organic lecithin suspension; (4) Add the silica-organic lecithin suspension to (2), stir at 400 rpm for 10 min, then cool it to 50°C to obtain a composite lubricant, and keep it warm for later use.

[0116] Performance Test 3: The hollow capsules prepared in Examples 17-19 were subjected to surface friction force testing and pass rate testing using the above testing methods. The specific test results are shown in Table 3.

[0117]

[0118] Conclusion: As can be seen from the results in Table 3 above, the test results of Examples 17-19 are better than those of Example 13, indicating that the addition of organic lecithin can significantly enhance the performance of the capsules. Among them, the performance test results of Example 17 are the best.

[0119] The following is a control experiment based on Example 17, with comparative examples 1 to 3, as detailed below:

[0120] Comparative Example 1: Comparative Example 1 is based on Example 17, with the following adjustment: the organic pullulan polysaccharide was directly dissolved, while other processes remained unchanged. Specifically:

[0121] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0122] S1: Add 100 parts organic pullulan, 0.5 parts potassium chloride, and 0.1 parts organic glycerol to 400 parts purified water at 50°C, and stir and disperse at 1500 rpm for 5 minutes.

[0123] Comparative Example 2: Comparative Example 2 is based on Example 17, with the following adjustment: silica is not added to the composite lubricant, while other processes remain unchanged. Specifically:

[0124] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0125] S31: Preparation of composite lubricant: (1) Add 1.2 parts organic cassava starch and 0.4 parts organic rice starch (in a ratio of 3:1) to 8 parts purified water and stir at 400 rpm for 10 min to obtain an organic starch suspension; (2) Stir the organic starch suspension at 650 rpm and heat it to 75°C, then continue to stir and keep it warm for 45 min; (3) Add 0.096 parts organic lecithin to purified water at 75°C and stir and disperse at 400 rpm for 10 min to obtain a silica-organic lecithin suspension; (4) Add the silica-organic lecithin suspension to (2), stir and disperse at 400 rpm for 10 min, then cool it to 50°C to obtain a composite lubricant, and keep it warm for later use.

[0126] Comparative Example 3: Comparative Example 3 is based on Example 17, with the following adjustments: no composite lubricant is added, and the gelling agent is prepared using carrageenan, while other processes remain unchanged. Specifically:

[0127] A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules:

[0128] S2: Add gelling agent to S1 and stir to disperse;

[0129] S21: Preparation of gelling agent: Disperse 4 parts of carrageenan into 50 parts of purified water at 50℃, stir and disperse at 100 rpm for 15 minutes to completely dissolve the organic gelling material, and then stir and disperse at 200 rpm for 15 minutes to obtain the gelling agent, and keep it warm for later use.

[0130] S22: Add the gelling agent prepared in S21 to the mixed solution obtained in S1, and stir and disperse at a stirring speed of 400 rpm for 10 min to obtain a mixed adhesive solution.

[0131] Performance Test 4: The hollow capsules prepared by Comparative Examples 1-3 were subjected to surface friction force testing and pass rate testing using the above testing methods. The specific test results are shown in Table 4.

[0132]

[0133] Conclusion: Based on the results in Table 4 above, and combined with the results in Tables 1 to 3 above, it can be seen that the improvements made in this invention in three aspects—the treatment of organic pullulan polysaccharide, the selection of gelling agent formulation, and the selection of composite lubricant formulation—have resulted in the comprehensive preparation of an organic pullulan polysaccharide empty capsule that combines low surface friction, antistatic properties, and a high machine pass rate. The minimum surface friction reaches 1.0N, and the machine pass rate is as high as 99.8%, which has significant practical application value.

[0134] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A method for preparing low-surface-friction organic pullulan polysaccharide empty capsules, characterized in that: Includes the following steps: S1: Add organic pullulan polysaccharide, potassium chloride, and organic glycerol to purified water, stir and disperse at 1000~2000 rpm for 2~10 minutes, then preheat to 45~60℃ for later use; S2: Mix organic gelling materials and purified water to prepare a gelling agent; then add the gelling agent to S1 and stir to disperse; S3: Mix organic starch, lubricant, and purified water to prepare a composite lubricant; then add the composite lubricant to S2, stir and disperse to obtain a mixed adhesive solution; S4: After degassing and filtration, the mixed adhesive solution is processed and shaped, dried, cut and assembled to obtain the empty capsule product, namely the low surface friction organic pullulan polysaccharide empty capsule. The preparation of the low-surface-friction organic pullulan polysaccharide empty capsules comprises the following raw material components in parts by weight: 100 parts organic pullulan polysaccharide, 0.1-1 parts potassium chloride, 0.05-1 parts organic glycerin, 0.5-5 parts organic gelling material, 0.4-3.2 parts organic starch, 0.1-0.8 parts lubricant, and 252-616 parts purified water; The gelling agent is prepared by mixing organic gelling materials and purified water in a mass ratio of (0.5~5):(50~100); The composite lubricant is prepared by mixing organic starch, lubricating agent, and purified water in a mass ratio of (0.4~3.2):(0.1~0.8):(2~16); The organic cementitious material is obtained by mixing and compounding organic guar gum and organic gum arabic in a mass ratio of (6~9):(1~4); The organic starch is obtained by mixing and compounding organic cassava starch and organic rice starch in a mass ratio of (2~4):(1~2); The lubricating agent is silicon dioxide; The composite lubricant also includes organic lecithin, which is used in amounts of 4-8 wt% of the amount of organic starch added.

2. The method for preparing a low-surface-friction organic pullulan polysaccharide empty capsule according to claim 1, characterized in that: The organic cementitious material is obtained by mixing and compounding organic guar gum and organic gum arabic in a mass ratio of (7~8):(2~3).

3. The method for preparing a low-surface-friction organic pullulan polysaccharide empty capsule according to claim 1, characterized in that: The organic starch is obtained by mixing organic cassava starch and organic rice starch in a mass ratio of 3:

1.

4. A low-surface-friction organic pullulan polysaccharide empty capsule, characterized in that: It is prepared by the preparation method according to any one of claims 1 to 3.

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