A metformin hydrochloride tablet compression device and compression method

Abstract

The application relates to the tablet compression molding technical field, and particularly discloses a metformin hydrochloride tablet compression molding device and a compression molding method, which comprise a base, a granulating cylinder and a compression molding mechanism are arranged on the base, a granulating plate is arranged at the bottom of the granulating cylinder, a plurality of through holes are arranged on the granulating plate, an extrusion plate is slidably arranged in the granulating cylinder, a feeding groove is arranged on the extrusion plate, a first driving element is arranged in the granulating cylinder, the first driving element is used for driving the extrusion plate to move up and down, a rotating shaft is arranged in the granulating cylinder, the rotating shaft is rotationally matched with the base, a scraper is arranged on the rotating shaft, the bottom end of the scraper is abutted against the granulating plate, a second driving element is arranged on the base, the second driving element is used for driving the rotating shaft to rotate, the second driving element drives the rotating shaft to rotate, the rotating shaft drives the scraper to rotate, the scraper pushes the material on the granulating plate and drops into the through holes of the granulating plate; and the application has the effect of improving the tablet molding quality.

Description

Technical Field

[0001] This invention relates to the field of tablet compression molding technology, specifically to a metformin hydrochloride tablet compression molding device and method. Background Technology

[0002] Metformin hydrochloride is a biguanide hypoglycemic drug. It appears as a white crystalline powder with a melting point of 223-226℃. It is readily soluble in water, soluble in methanol, slightly soluble in ethanol, and insoluble in ether and chloroform. It is used for patients with mild diabetes. It lowers blood glucose by inhibiting hepatic gluconeogenesis and promoting peripheral tissue glucose utilization. Its pharmacological effects include inhibiting mitochondrial respiratory chain complex I and activating AMPK-mediated target gene transcription.

[0003] The production process of metformin hydrochloride tablets includes pretreatment of raw materials and excipients, weighing and mixing, granulation, material preparation and total mixing, and tableting. Among these, the role of granulation is as follows: Metformin hydrochloride raw materials have poor flowability, and direct tableting can easily lead to large differences in tablet weight and uneven content. Granulation can bind the raw materials and excipients into uniform particles, improving flowability and compressibility. The role of tableting is to compress qualified granules into tablets of specified shape, hardness and thickness, which is the core step in formulation formation.

[0004] Chinese Patent CN104173191B discloses a granulator, which includes a compaction cylinder, a compaction piston, a granulation cylinder, a granulation piston, and a pusher plate. Both the compaction cylinder and the granulation cylinder are rectangular troughs. The compaction cylinder and the granulation cylinder are fixed together side by side. An elongated opening is provided at the bottom end of the side wall between the compaction cylinder and the granulation cylinder, and at the bottom end of the side wall of the compaction cylinder opposite to the side wall. The pusher plate extends into the elongated opening from one side of the compaction cylinder. The compaction piston is placed inside the compaction cylinder and slides in cooperation with the inner wall of the compaction cylinder. The granulation piston is placed inside the granulation cylinder and slides in cooperation with the inner wall of the granulation cylinder. Several through holes are evenly distributed on the bottom surface of the granulation cylinder. The compaction piston, the granulation piston, and the pusher plate are all driven by a hydraulic system to make linear motion.

[0005] In the above technology, during the manufacturing process, the material is compacted by a compaction cylinder and pushed into a granulation cylinder, where it is then extruded into regularly shaped granules. During the extrusion molding process, some material may accumulate at the bottom of the extrusion cylinder where there are no through holes, which can easily lead to different degrees of compactness of the extruded granules and affect the molding quality. Summary of the Invention

[0006] This invention provides a metformin hydrochloride tablet compression device and compression method, aiming to solve the technical problem in the prior art where, during the manufacturing process, the material is compacted by a compaction cylinder, pushed into a granulation cylinder, and then extruded into regularly shaped granules. During the extrusion molding process, some material accumulates at the bottom of the extrusion cylinder where there are no through holes, which can easily lead to different degrees of compactness of the extruded granules and affect the molding quality.

[0007] In a first aspect, the present invention provides a metformin hydrochloride tablet molding apparatus, comprising a base, a granulation cylinder and a molding mechanism on the base, a granulation plate at the bottom of the granulation cylinder, a plurality of through holes on the granulation plate, an extrusion plate slidably fitted inside the granulation cylinder, a feed groove on the extrusion plate, a first driving member inside the granulation cylinder for driving the extrusion plate to move up and down, a rotating shaft inside the granulation cylinder for rotatingly fitting with the base, a scraper on the rotating shaft, the bottom end of the scraper abutting against the granulation plate, and a second driving member on the base for driving the rotating shaft to rotate. The second driving member drives the rotating shaft to rotate, the rotating shaft drives the scraper to rotate, and the scraper pushes the material on the granulation plate and drops it into the through holes of the granulation plate.

[0008] Beneficial effects: The material enters the granulation cylinder from the top and falls onto the extrusion plate. The material slides along the inclined surface of the upper surface of the extrusion plate and enters the space between the extrusion plate and the granulation plate through the feed chute. At the same time, the second drive unit drives the rotating shaft to rotate, thereby driving the scraper to rotate around the shaft. The scraper continuously pushes the material on the upper surface of the granulation plate, thereby preventing the material from accumulating on the granulation plate. After the extrusion plate squeezes the material accumulated on the granulation plate, the particle density is different from that of other materials, which affects the granulation quality.

[0009] Preferably, the feed trough can fit with the scraper, and the upper surface of the extrusion plate has a double-sloped structure.

[0010] Preferably, the scraper includes a fixed rod, a guide rod, an intermediate plate, and a bottom plate. The fixed rod is located above the extrusion plate and is connected to the side wall of the rotating shaft. The top end of the guide rod is connected to the fixed rod, and its bottom end passes through the feed trough and extends downward. Multiple intermediate plates are distributed vertically on the guide rod at intervals. The bottom plate is fixedly connected to the bottom end of the guide rod.

[0011] Beneficial effects: After the material enters the extrusion plate and granulation plate, the rotating shaft rotates, which in turn drives the guide rod, intermediate plate and bottom plate to rotate around the rotating shaft, thereby stirring the material and making it fully mixed.

[0012] Preferably, two adjacent intermediate plates and the intermediate plate and the bottom plate are connected by a first elastic element. Each intermediate plate is slidably engaged with the guide rod. A first stop is provided on the inner side of the intermediate plate. The first stop is elastically connected to the intermediate plate. The first stop located at the extrusion plate can stop against the bottom end of the extrusion plate.

[0013] Beneficial effects: When the extrusion plate moves downward, its bottom end stops against the first stop block, and the first stop block pushes the intermediate plate downward until multiple intermediate plates and the bottom plate are in contact with each other, thus forming a sealing partition. This prevents the extrusion plate from causing different volumes of the granulation cylinder at different heights due to the presence of intermediate plates and the bottom plate, which would result in different particle compactness.

[0014] Preferably, the top end of the extrusion plate is provided with an elastic telescopic rod, the top end of the elastic telescopic rod is provided with a mounting block, and a second stop block is elastically connected to the mounting block. The second stop block can be housed inside the mounting block and can abut against the top end of the uppermost intermediate plate.

[0015] Beneficial effects: When the bottom of the extrusion plate passes the first stop, the second stop stops against the top of the middle plate and restricts the middle plate from moving upward, preventing the middle plate from bouncing upward in advance, causing the feed chute to open, and the material to overflow from the feed chute when the material is extruded.

[0016] Preferably, the bottom end of the guide rod is provided with a cleaning block, which is connected to the bottom end of the guide rod through a second elastic element. The cleaning block can extend into the through hole of the granulation plate. The bottom end of the cleaning block has a beveled end, which can abut against the side wall of the through hole.

[0017] Beneficial effect: By setting up the cleaning block, when the cleaning block extends into the through hole of the granulation plate, it can squeeze out the material in the through hole of the granulation plate, thereby cleaning the material in the through hole of the granulation plate.

[0018] Preferably, two symmetrically distributed cutters are provided below the granulation plate. The cutters slide in cooperation with the granulation cylinder. A driving mechanism is provided on the base, which is used to drive the two cutters to move closer or further apart.

[0019] Preferably, the upper surface of the cutter can fit into the granulation plate, thereby sealing the granulation plate.

[0020] Preferably, the base is provided with a material collection trough, which is located below the granulation cylinder, and the bottom surface of the material collection trough is a sloping structure.

[0021] Secondly, the present invention provides a metformin hydrochloride tablet molding method, utilizing the aforementioned metformin hydrochloride tablet molding apparatus, comprising the following steps:

[0022] Material granulation: The material is added into the granulation cylinder and reaches the granulation plate through the feed chute. The extrusion plate extrudes and granulates the material on the granulation plate.

[0023] Material tableting: After granulation, the granules processed from the granulation cylinder are added to the pressing mechanism for pressing and forming.

[0024] The beneficial effects of this invention are as follows:

[0025] In this invention, the material enters the granulation cylinder from the top of the granulation cylinder through the scraper and falls onto the extrusion plate. The material slides along the inclined surface of the upper surface of the extrusion plate and enters the space between the extrusion plate and the granulation plate through the feed chute. At the same time, the second driving component drives the rotating shaft to rotate, thereby causing the scraper to rotate around the rotating shaft. The scraper continuously pushes the material on the upper surface of the granulation plate, thereby preventing the material from accumulating on the granulation plate. After the extrusion plate extrudes the material accumulated on the granulation plate, the particle density is different from that of other materials, which affects the granulation quality. Attached Figure Description

[0026] Figure 1 This is a schematic diagram of the overall structure of the present invention.

[0027] Figure 2 This is a structural schematic diagram illustrating the connection relationship between the granulation cylinder and the base according to the present invention.

[0028] Figure 3 This is a structural schematic diagram illustrating the positional relationship between the cutter and the granulation plate of the present invention.

[0029] Figure 4 This is a structural schematic diagram illustrating the connection relationship between the extrusion plate and the rotating sleeve according to the present invention.

[0030] Figure 5 This is a schematic diagram illustrating the connection relationship between the transmission belt and the rotating shaft according to the present invention.

[0031] Figure 6 This is a structural schematic diagram illustrating the connection relationship between the first elastic element and the intermediate plate according to the present invention.

[0032] Figure 7 This is a structural schematic diagram illustrating the connection relationship between the second elastic member and the cleaning block according to the present invention.

[0033] Figure 8 This is a schematic diagram illustrating the connection relationship between the driver and the cutter according to the present invention.

[0034] Figure label:

[0035] 1. Base; 2. Granulation cylinder; 21. Forming mechanism; 3. Granulation plate; 4. Extrusion plate; 41. Feed trough; 42. Rotating sleeve; 421. Matching key; 5. Mounting seat; 6. First driving component; 7. Rotating shaft; 8. Second driving component; 9. Transmission belt; 101. Fixing rod; 102. Guide rod; 103. Intermediate plate; 104. Base plate; 105. First elastic component; 11. First stop block; 12. Elastic telescopic rod; 13. Mounting block; 14. Second stop block; 15. Cleaning block; 16. Second elastic component; 17. Cutter; 181. Support plate; 182. Driver; 19. Collection trough. Detailed Implementation

[0036] Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain the present invention, and should not be construed as limiting the present invention.

[0037] like Figures 1-8 The present invention discloses a metformin hydrochloride tablet compression device, comprising: a base 1, a granulation cylinder 2 fixedly disposed on the base 1, and a compression mechanism 21 fixedly disposed on the base 1. The compression mechanism 21 is used to compress the granules processed by the granulation cylinder 2 into shape. The top end of the granulation cylinder 2 is provided with a feed port. A granulation plate 3 is fixedly connected inside the granulation cylinder 2. The granulation plate 3 is provided with a plurality of spaced through holes. An extrusion plate 4 is also slidably fitted inside the granulation cylinder 2. The extrusion plate 4 is located above the granulation plate 3. The upper surface of the extrusion plate 4 is a double-sloped structure. The extrusion plate 4 is also provided with a feed groove 41 extending radially therefrom. A mounting base 5 is rotatably connected inside the granulation cylinder 2. A first driving member 6 is fixedly connected to the mounting base 5. The first driving member 6 is a hydraulic cylinder. A connecting rod is fixedly installed on its output end. The connecting rod is fixedly connected to the extrusion plate 4. The first driving member 6 is used to drive the extrusion plate 4 to move up and down. When materials need to be processed, the materials are first added into the granulation cylinder 2 through the feed port of the granulation cylinder 2. The materials reach the granulation plate 3 through the feed trough 41. Then the first drive unit 6 is started. The first drive unit 6 drives the extrusion plate 4 to descend. The extrusion plate 4 extrudes the materials in the through holes of the granulation plate 3 to form granular materials. Subsequently, the granular materials are transported to the pressing mechanism 21 for pressing and molding processing.

[0038] Among them, such as Figure 1 and Figure 2The pressing mechanism 21 includes a tablet press body, a rotating disk mounted on the tablet press body, and an upper punch and a lower punch mounted on the rotating disk. The tablet press body is equipped with a drive assembly 1 for driving the rotating disk to rotate. The rotating disk has multiple vertically arranged pressing holes. The tablet press body is also equipped with multiple drive assemblies 2 for driving the upper punch and the lower punch to rise and fall respectively. When the material is pressed, the granular material is first added to the pressing hole. Then, drive assembly 1 is activated to drive the rotating disk to rotate. When the rotating disk rotates, it can drive the upper punch and the lower punch to rotate synchronously. Then, drive assembly 2 is activated to drive the upper punch to descend. The upper punch inserts into the pressing hole and cooperates with the lower punch to press the material in the pressing hole into shape. After pressing is completed, the upper punch is activated, rises and resets. Drive assembly 2 is activated to drive the lower punch to rise and push the tablet out of the pressing hole. The tablet is finally conveyed out from the tablet press body, completing the pressing operation of the material.

[0039] like Figures 1 to 6 As shown, the granulation cylinder 2 is also equipped with a rotating shaft 7. The bottom end of the rotating shaft 7 is rotatably engaged with the base 1, and its top end passes through the granulation plate 3 and the extrusion plate 4 and extends upward. The rotating shaft 7 is rotatably engaged with the granulation plate 3. A rotating sleeve 42 is fixedly installed on the extrusion plate 4. The rotating sleeve 42 is slidably engaged with the rotating shaft 7. The rotating sleeve 42 can move up and down along the rotating shaft 7. A mating key 421 is provided inside the rotating sleeve 42. A mating groove is provided on the rotating shaft 7. The mating key 421 is slidably engaged in the mating groove. A second driving member 8 is provided on the base 1. The second driving member 8 is a motor. A transmission belt 9 is provided between its output end and the rotating shaft 7. The second driving member 8 drives the rotating shaft 7 to rotate through the transmission belt 9. The rotating shaft 7 drives the extrusion plate 4 to rotate through the mating key 421, thereby driving the mounting base 5 and the first driving member 6 to rotate inside the granulation cylinder 2.

[0040] like Figures 1 to 6As shown, the rotating shaft 7 is also equipped with scrapers. There are two scrapers, which are symmetrically distributed on both sides of the rotating shaft 7 along the central axis of the rotating shaft 7. Each scraper includes a fixed rod 101, a guide rod 102, an intermediate plate 103, and a bottom plate 104. The fixed rod 101 is located above the extrusion plate 4 and is fixedly connected to the rotating shaft 7. The guide rods 102 are evenly spaced along the length of the fixed rod 101, and the top of the guide rod 102 is fixedly connected to the fixed rod 101. Multiple intermediate plates 103 are spaced vertically on the guide rods 102. Each intermediate plate 103 has... The bottom plate 104 is fixedly connected to the bottom end of the guide rod 102 in sliding engagement with the guide rod 102. The two adjacent intermediate plates 103 and the bottom intermediate plate 103 are connected to the bottom plate 104 by a first elastic element 105, which is an elastic column. A first stop 11 is provided at the bottom of the side wall of the intermediate plate 103 near the rotating shaft 7. The first stop 11 is elastically connected to the intermediate plate 103 and can be retracted into the intermediate plate 103. The first stop 11 located at the extrusion plate 4 can abut against the bottom end of the rotating sleeve 42. An elastic telescopic rod 12 extends upward from the top of the rotating sleeve 42. A mounting block 13 is provided at the top of the elastic telescopic rod 12. A second stop 14 is elastically connected to the mounting block 13 and can be retracted into the mounting block 13. The second stop 14 can abut against the top of the uppermost intermediate plate 103.

[0041] like Figure 3 and Figure 7 The bottom end of the guide rod 102 is elastically connected to the cleaning block 15 via the second elastic element 16. The elastic force of the second elastic element 16 is small. The bottom end of the cleaning block 15 is a beveled end and can extend into the through hole of the granulation plate 3. The diameter of the cleaning block 15 is smaller than the diameter of the through hole, and the beveled end of the cleaning block 15 can abut against the side wall of the through hole.

[0042] like Figure 1 , Figure 3 and Figure 8 As shown, two cutters 17 are also provided below the granulation plate 3. The two cutters 17 are symmetrically distributed about the central axis of the rotating shaft 7, and both cutters 17 are in sliding engagement with the granulation cylinder 2. The upper surface of the cutters 17 can fit against the lower surface of the granulation plate 3. When the two cutters 17 are in contact with each other, they can seal the granulation plate 3. A drive mechanism is provided on the base 1. The drive mechanism includes a support plate 181 and a driver 182. The support plate 181 is fixedly connected to the base 1, and the driver 182 is fixedly mounted on the support plate 181. The driver 182 is directly a hydraulic cylinder. The output shaft of the driver 182 is fixedly connected to the cutters 17. When the driver 182 works, it can drive the two cutters 17 to move closer or further apart.

[0043] like Figure 1 and Figure 2As shown, the base 1 is also provided with a material collection trough 19. The top of the material collection trough 19 is connected to the bottom of the granulation cylinder 2. The bottom surface of the material collection trough 19 is a sloping structure. The granular material falls into the material collection trough 19 and can slide out of the material collection trough 19 along the bottom surface of the material collection trough 19.

[0044] The implementation principle of the metformin hydrochloride tablet compression device of the present invention is as follows: In the initial state, the two cutters 17 are in contact with each other and the granulation plate 3 is closed. The height of the extrusion plate 4 is higher than the height of the top middle plate 103. When the material needs to be processed, the material is first added into the granulation cylinder 2 from the feed port of the granulation cylinder 2. The material reaches the granulation plate 3 through the feed trough 41.

[0045] After the material is filled, the second drive unit 8 is started. The second drive unit 8 drives the rotating shaft 7 to rotate through the transmission belt 9. The rotating shaft 7 drives the extrusion plate 4 and the scraper to rotate synchronously. The guide rod 102, the intermediate plate 103 and the bottom plate 104 can stir the material between the extrusion plate 4 and the granulation plate 3, thereby ensuring that the material is mixed evenly.

[0046] Then the first driving component 6 is activated, which drives the extrusion plate 4 to move downward. During the downward movement of the extrusion plate 4, the bottom end of the rotating sleeve 42 gradually approaches the first stop 11 and stops with the first stop 11. At this time, the top end of the uppermost middle plate 103 stops with the second stop 14. The rotating sleeve 42 pushes the uppermost middle plate 103 downward through the first stop 11. The uppermost middle plate 103 moves downward and pushes the middle plate 103 below it downward, so that multiple middle plates 103 and the bottom plate 104 fit together to form a sealing partition. The two sealing partitions can divide the annular cavity between the extrusion plate 4 and the granulation plate 3 into two semi-circular cavities. The feed chute 41 fits with the corresponding sealing partition, the first elastic element 105 contracts, the extrusion plate 4 continues to move downward, and the extrusion plate 4 cooperates with the granulation plate 3 to compact the material.

[0047] After the material is fully compacted, the driver 182 is started. The driver 182 drives the cutter 17 to move away from each other, and the extrusion plate 4 moves downward to squeeze the material out of the through hole of the granulation plate 3. After the extrusion plate 4 squeezes out the material of a set length, the driver 182 drives the two cutters 17 to move closer to each other to cut the material protruding from the bottom surface of the granulation plate 3 into granules. Then the two cutters 17 move away from each other again and repeat the above process to complete the granulation process of the material.

[0048] During the material granulation process, the rotating shaft 7 continues to rotate and drives the bottom plate 104 to continuously push the material on the upper surface of the granulation plate 3 to prevent the material from accumulating on the granulation plate 3. At the same time, during the rotation of the bottom plate 104, when the bottom end of the guide rod 102 is aligned with the through hole of the granulation plate 3, the cleaning block 15 can extend into the through hole under the elastic force of the second elastic element 16 and push the material in the through hole downward to keep the through hole unobstructed.

[0049] As the extrusion plate 4 moves downward along the sealing partition, it gradually passes the first stop 11 of the uppermost intermediate plate 103. Since the second stop 14 stops at the top of the uppermost intermediate plate 103, the elastic telescopic rod 12 extends and stores force. When the extrusion plate 4 moves to stop at the first stop 11 of the next intermediate plate 103, the elastic telescopic rod 12 extends to its limit. At this time, the uppermost intermediate plate 103 can push the second stop 14 into the mounting block 13 and release the restriction on the uppermost intermediate plate 103. The uppermost intermediate plate 103 bounces upward under the elastic force of the first elastic element 105. The extrusion plate 4 moves downward so that multiple intermediate plates 103 can be separated from top to bottom in sequence until the extrusion plate 4 comes into contact with the granulation plate 3. Then, the first driving element 6 drives the extrusion plate 4 to move upward. When the height of the extrusion plate 4 is higher than the bottom plate 104, it can be fed again without the extrusion plate 4 rising to the highest point, saving feeding time and improving granulation efficiency.

[0050] After the material is processed in the granulation cylinder 2, the granular material passes through the bottom of the granulation cylinder 2 and is discharged through the collection trough 19. When the granular material is pressed, the granular material is first added into the pressing hole. Then, the drive component one is started to drive the rotating disk to rotate. When the rotating disk rotates, it can drive the upper punch and the lower punch to rotate synchronously. Then, the drive component two is started to drive the upper punch to descend. The upper punch is inserted into the pressing hole and cooperates with the lower punch to press the material in the pressing hole into shape. After pressing is completed, the upper punch is started, the upper punch rises and resets. The drive component two is started to drive the lower punch to rise and push the tablet out of the pressing hole. The tablet is finally conveyed out from the tablet press body, completing the pressing operation of the material.

[0051] like Figures 1-8 The present invention also provides a method for molding metformin hydrochloride tablets, which includes the following steps:

[0052] Material granulation: The material is added into the granulation cylinder 2 and reaches the granulation plate 3 through the feed trough 41. The extrusion plate 4 extrudes and granulates the material on the granulation plate 3.

[0053] Material tableting: After granulation, the granules processed from the granulation cylinder 2 are added to the pressing mechanism 21 for pressing and forming.

[0054] In the description of this invention, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," and "circumferential" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0055] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this invention, "a plurality of" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0056] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A metformin hydrochloride tablet molding device, comprising a base (1), wherein a granulation cylinder (2) and a molding mechanism (21) are provided on the base (1), and a granulation plate (3) is provided at the bottom of the granulation cylinder (2), wherein the granulation plate (3) is provided with a plurality of through holes, characterized in that, The granulation cylinder (2) is slidably fitted with an extrusion plate (4), and the extrusion plate (4) is provided with a feed groove (41). The granulation cylinder (2) is provided with a first driving member (6), which is used to drive the extrusion plate (4) to move up and down. The granulation cylinder (2) is provided with a rotating shaft (7), which is rotatably fitted with the base (1). The rotating shaft (7) is provided with a scraper, and the bottom end of the scraper abuts against the granulation plate (3). The base (1) is provided with a second driving member (8), which is used to drive the rotating shaft (7) to rotate. The scraper includes a fixed rod (101), a guide rod (102), an intermediate plate (103), and a bottom plate (104). The fixed rod (101) is located above the extrusion plate (4) and is connected to the side wall of the rotating shaft (7). The top end of the guide rod (102) is connected to the fixed rod (101), and its bottom end passes through the feed chute (41) and extends downward. Multiple intermediate plates (103) are distributed vertically and horizontally on the guide rod (102). The bottom plate (104) is fixedly connected to the bottom end of the guide rod (102). Two adjacent intermediate plates (103) and the intermediate plate (104) are also connected to the bottom end of the guide rod (102). The middle plate (103) is connected to the base plate (104) by a first elastic element (105). Each middle plate (103) is slidably engaged with the guide rod (102). The inner side of the middle plate (103) is provided with a first stop (11), and the first stop (11) is elastically connected to the middle plate (103). The top end of the extrusion plate (4) is provided with an elastic telescopic rod (12), and the top end of the elastic telescopic rod (12) is provided with a mounting block (13). The mounting block (13) is elastically connected with a second stop (14), and the second stop (14) can be stored in the mounting block (13). After the materials are mixed evenly, the first driving component (6) drives the extrusion plate (4) to move downwards. The bottom end of the rotating sleeve (42) gradually approaches the first stop (11) and stops with the first stop (11). At this time, the top end of the uppermost middle plate (103) stops with the second stop (14). The rotating sleeve (42) pushes the uppermost middle plate (103) downwards through the first stop (11) and pushes the middle plate (103) below it downwards, so that multiple middle plates (103) and the bottom plate (104) fit together to form a sealing partition. As the extrusion plate (4) moves along the sealing partition... As the plate moves downward, the extrusion plate (4) gradually passes the first stop (11) of the uppermost intermediate plate (103). At this time, the elastic telescopic rod (12) extends and stores force. When the extrusion plate (4) moves to stop with the first stop (11) of the next intermediate plate (103), the elastic telescopic rod (12) extends to its limit. At this time, the uppermost intermediate plate (103) can push the second stop (14) into the mounting block (13) and release the restriction on the uppermost intermediate plate (103). The extrusion plate (4) moves downward so that multiple intermediate plates (103) can be separated from top to bottom in sequence.

2. The metformin hydrochloride tablet molding apparatus according to claim 1, characterized in that, The feed trough (41) can fit with the scraper, and the upper surface of the extrusion plate (4) is a double-sloped structure.

3. The metformin hydrochloride tablet molding apparatus according to claim 1, characterized in that, The bottom end of the guide rod (102) is provided with a cleaning block (15). The cleaning block (15) is connected to the bottom end of the guide rod (102) through a second elastic element (16). The cleaning block (15) can extend into the through hole of the granulation plate (3). The bottom end of the cleaning block (15) has a beveled end, which can abut against the side wall of the through hole.

4. The metformin hydrochloride tablet molding apparatus according to claim 1, characterized in that, Two symmetrically distributed cutters (17) are provided below the granulation plate (3). The cutters (17) slide in cooperation with the granulation cylinder (2). A driving mechanism is provided on the base (1). The driving mechanism is used to drive the two cutters (17) to move closer or further away from each other.

5. The metformin hydrochloride tablet molding apparatus according to claim 4, characterized in that, The upper surface of the cutter (17) can fit against the granulation plate (3) to seal the granulation plate (3).

6. The metformin hydrochloride tablet molding apparatus according to claim 1, characterized in that, The base (1) is provided with a material collection trough (19), which is located below the granulation cylinder (2). The bottom surface of the material collection trough (19) is a sloping structure.

7. A method for molding metformin hydrochloride tablets, characterized in that, The metformin hydrochloride tablet molding apparatus according to any one of claims 1-6 comprises the following steps: Material granulation: The material is added into the granulation cylinder (2) and reaches the granulation plate (3) through the feed trough (41). The extrusion plate (4) extrudes and granulates the material on the granulation plate (3). Material tableting: After granulation, the granules processed from the granulation cylinder (2) are added to the pressing mechanism (21) for pressing and forming.

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