Traditional Chinese medicine composition for treating liver qi heat disorder

Abstract

The invention discloses a traditional Chinese medicine composition for treating liver qi heat disorder. The traditional Chinese medicine composition is used for solving the problems that related medicine compositions focuses on liver heat release, related organs are not comprehensively adjusted for cooperative treatment, and diseases cannot be fundamentally treated. The traditional Chinese medicine composition for treating the liver qi heat disorder is prepared from the following components: fennel, fructus lycii, chicory seeds, flos chrysanthemi, pericarpium citri reticulatae, celery seeds, rose petals, coriander seeds, cardamom, semen cassiae, herba menthae, chicory seeds, flos chrysanthemi and fructus lycii. According to the scheme, the medicine composition acts on the liver, the stomach and the intestines to treat the liver qi and heat disorder, the medicine composition I and the medicine composition III are used for regulating abnormal blood quality respectively, and the liver qi and heat disorder is fundamentally improved.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine combination technology for treating liver qi and heat imbalance syndrome, specifically, to a traditional Chinese medicine combination for treating liver qi and heat imbalance syndrome. Background Technology

[0002] Uyghur medicine - Liver Qi and Heat Imbalance Syndrome refers to a condition characterized by an excess of heat in the liver's Qi. Symptoms often include dull pain in the liver area, slight hepatomegaly, indigestion, nausea, poor appetite, and constipation. Some patients may experience mild yellowing of the whites of the eyes, nighttime diarrhea, and rib pain.

[0003] The focus of the relevant drug combinations is on clearing liver heat, without comprehensively adjusting the treatment of related organs and failing to fundamentally treat the disease. Summary of the Invention

[0004] The purpose of this invention is to provide a traditional Chinese medicine combination for treating liver qi stagnation and heat disorder, which solves the problem that related drug combinations focus on clearing liver heat, without comprehensively adjusting related organs for coordinated treatment and failing to fundamentally treat the disease.

[0005] To address the above problems, the present invention provides the following technical solution: A traditional Chinese medicine combination for treating liver qi stagnation and heat disorder consists of the following ingredients: fennel, dried tangerine peel, cardamom, cassia seed, peppermint, and rose petals.

[0006] In related embodiments, a traditional Chinese medicine combination for treating liver qi stagnation and heat disorder also includes celery seeds and coriander seeds.

[0007] In related embodiments, a traditional Chinese medicine combination for treating liver qi stagnation and heat disorder also includes celery chicory seeds, chrysanthemum, and wolfberry.

[0008] In the relevant embodiments, the weight parts of each component are as follows: 3-10 parts fennel, 5-15 parts wolfberry, 10-20 parts chicory seed, 5-15 parts chrysanthemum, 3-10 parts dried tangerine peel, 3-10 parts celery seed, 3-10 parts rose petals, 5-15 parts coriander seed, 5-15 parts cardamom, 5-15 parts cassia seed, and 5-15 parts peppermint.

[0009] In the relevant embodiments, 5 parts fennel, 10 parts goji berries, 15 parts chicory seeds, 5 parts dried tangerine peel, 5 parts celery seeds, 5 parts rose petals, 10 parts coriander seeds, 10 parts cassia seeds, 10 parts chrysanthemum, 10 parts cardamom, and 10 parts mint are used.

[0010] In relevant embodiments, the traditional Chinese medicine combination for treating liver qi-heat imbalance syndrome is any one of decoction, pill, powder, ointment, elixir, granule, oral liquid, capsule, or tablet.

[0011] A method for preparing a traditional Chinese medicine combination for treating liver qi stagnation and heat disorder includes the following steps: Weigh the raw materials and water in a ratio of 1:2, decoct over a low flame for 15 minutes, and filter the liquid. Take after breakfast and dinner.

[0012] Compared with the prior art, the present invention has the following beneficial effects: Combination 1 of wolfberry, chicory seed, and chrysanthemum regulates abnormal blood quality, clears liver obstruction, clears heat and reduces inflammation, eliminates jaundice, and promotes diuresis and reduces swelling; Combination 2 of tangerine peel, mint, cardamom, fennel, rose petals, and cassia seed disperses qi and relieves bloating, warms the middle jiao and relieves pain, warms the stomach and promotes digestion, and moistens the intestines to facilitate bowel movements; it mainly acts on the stomach and intestines; Combination 3 of celery seed, coriander seed, and rose petals mainly acts on the body to regulate abnormal blood quality; the aforementioned three combinations of drugs act on the liver, stomach, and intestines respectively, synergistically treating liver qi-heat imbalance, and Combination 1 and Combination 3 respectively regulate abnormal blood quality to fundamentally improve liver qi-heat imbalance. Detailed Implementation

[0013] The present invention will be further described below with reference to embodiments, and the embodiments of the present invention include, but are not limited to, the following embodiments.

[0014] Example 1

[0015] A traditional Chinese medicine combination for treating liver qi stagnation and heat disorder consists of the following components by weight: 3 parts fennel, 5 parts wolfberry, 10 parts chicory seed, 5 parts chrysanthemum, 3 parts dried tangerine peel, 3 parts celery seed, 3 parts rose petals, 5 parts coriander seed, 5 parts cardamom, 5 parts cassia seed, and 5 parts peppermint.

[0016] The preparation method includes the following steps: The decoction method for the drug combination includes the following steps: Weigh the raw materials and water in a ratio of 1:2, decoct over a low flame for 15 minutes, and filter out the liquid. Take after breakfast and dinner.

[0017] Example 2

[0018] The difference between this embodiment and Embodiment 1 is that the ingredients are: 5 parts fennel, 10 parts goji berries, 15 parts chicory seeds, 5 parts dried tangerine peel, 5 parts celery seeds, 5 parts rose petals, 10 parts coriander seeds, 10 parts cassia seeds, 10 parts chrysanthemum, 10 parts cardamom, and 10 parts mint.

[0019] Example 3

[0020] The difference between this embodiment and Embodiment 1 is that the ingredients are: 10 parts fennel, 15 parts goji berries, 20 parts chicory seeds, 15 parts chrysanthemum, 10 parts dried tangerine peel, 10 parts celery seeds, 10 parts rose petals, 15 parts coriander seeds, 15 parts cardamom, 15 parts cassia seeds, and 15 parts mint.

[0021] Animal experiments

[0022] Animal species: Male mouse Animal age: 6 weeks old Animal weight: Approximately 20g The etiology and pathogenesis of alcoholic liver injury (ALD) in Uyghur medicine are related to "liver heat," and the treatment principle is "clearing liver heat." Therefore, mice with alcoholic liver injury were selected as the evaluation model.

[0023] An acute alcoholic liver injury mouse model was established by gavage (ig) with 40% ethanol (EtOH). Serum liver function enzymes (ALT, AST) and lipid markers (TC, TG, HDL-C, LDL-C), as well as the levels of lipid peroxidation-related enzymes (MDA, SOD, CAT, GSH-Px) and alcohol metabolism enzymes (ADH) in the liver tissue of mice were detected using ELISA. HE staining, Oil Red O staining, and Masson staining were used to observe the pathological morphology, fatty degeneration, and fibrosis degree of the liver tissue. The results showed that the serum AST, ALT, TG, TC, LDL-C and liver MDA levels in the model group were significantly increased, while the serum HDL-C and liver GSH-Px, SOD, CAT, and ADH levels were significantly decreased (P<0.05).

[0024] HE staining of liver tissue samples from the model group mice revealed indistinct hepatic lobule structure, narrowing of hepatic sinusoids, hepatocyte swelling with sheet-like ballooning degeneration, and pyknosis of a small number of hepatocyte nuclei. Lymphocyte infiltration foci were easily observed within the hepatic lobules. Oil Red O staining showed a large amount of fat accumulation, and Masson staining revealed blue collagen fibers. These biochemical and pathological indicators indicate that the acute ALD mouse model was successfully induced.

[0025] Mice were randomly divided into four groups. Groups one through three were treated with the herbal combinations described in Examples 1-3, while group four served as a control group and received no treatment. After treatment, groups one through three showed good symptom recovery, while group four experienced a worsening of the condition. Serum liver function enzymes (ALT, AST), blood lipids (TC, TG, HDL-C, and LDL-C), lipid peroxidation-related enzymes (MDA, SOD, CAT, GSH-Px), and alcohol metabolism enzymes (ADH) in groups one through three showed significant changes (P<0.05). Furthermore, the liver tissue of ALD mice showed significant pathological improvement.

[0026] Case

[0027] From May 2023 to October 2024, over 50 patients with liver qi stagnation and heat imbalance were treated primarily with Western medical chemical testing and traditional Chinese medicine. Clinical follow-up surveys showed that over 95% of patients recovered well, with satisfactory therapeutic effects.

[0028] I. Diagnostic Points

[0029] 1. Western medical chemical test results are the standard. 2. Traditional Chinese Medicine Syndrome Differentiation 3. Other examinations are supplementary.

[0030] II. Brief Case Information From May 2023 to October 2024, I presided over the diagnosis and treatment of more than 50 patients with liver qi and heat imbalance. Among them, 5 patients (with complications such as severe cirrhosis and hepatitis) were admitted for inpatient treatment (during which I participated in some diagnosis and treatment and consultations). The remaining patients were treated with outpatient observation and treatment mainly based on traditional Chinese medicine conditioning. All patients recovered well and the therapeutic effect was satisfactory.

[0031] (II) Treatment methods: The treatment plan was based on Western medical examination to determine the disease, and Chinese medicine diagnosis and treatment as the main approach, supplemented by Western medicine.

[0032] (1) Western medical examination (necessary examinations provide a reliable basis for accurate diagnosis) 1. Liver function tests: These include serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin. These indicators can reflect liver inflammation, damage, and metabolic function.

[0033] 2. Hepatitis B virus marker detection: Hepatitis B virus marker detection includes HBsAg, HBsAb, HBeAg, HBeAb, HBcAg, and HBcAb, which help determine the viral infection status and viral replication level.

[0034] 3. Blood Analysis: Blood analysis mainly includes indicators such as hemoglobin, white blood cells, and platelets. Hepatitis may cause blood system abnormalities such as anemia, leukopenia, and thrombocytopenia. Blood analysis helps to assess the severity of the condition.

[0035] 4. Imaging examinations: Imaging examinations include liver ultrasound, CT, MRI, etc., which can observe the morphology, size, structure and lesions of the liver, providing a basis for diagnosis and differential diagnosis.

[0036] 5. Liver pathological examination: Liver pathological examination is the gold standard for diagnosing hepatitis. Liver tissue can be obtained through liver biopsy or laparoscopy to observe the degree of liver inflammation, fibrosis and cirrhosis.

[0037] 6. Other checks.

[0038] (2) Traditional Chinese medicine treatment

[0039] Case 1: Brief Medical History Patient Zhang XX, male, 50 years old, visited on June 7, 2023 (outpatient number: 0596711). Liver function tests showed abnormal serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Liver imaging showed hepatomegaly. He reported nausea and aversion to greasy food. Palpation confirmed left hypochondriac pain. He was diagnosed with liver qi-heat imbalance and treated with a traditional Chinese medicine combination for liver qi-heat imbalance, 150-180ml twice a day after meals. On June 27, he returned for a follow-up visit, reporting left hypochondriac pain and easier bowel movements. Liver function tests showed that serum ALT and AST had returned to normal, and liver morphology was normal. He then continued using the traditional Chinese medicine combination for liver qi-heat imbalance for another week, 150-180ml twice a day after meals, to consolidate the therapeutic effect. Following hospital procedures, he was followed up with outpatient visits for six months, and the recovery was satisfactory.

[0040] Case 2: Brief Medical History Patient Chen XX, female, 78 years old, presented with a two-month history of persistent burning sensation in her back and epigastric region (normal body temperature) following a cold. The symptoms worsened with emotional excitement, accompanied by irritability and frequent outbursts of anger over minor matters. She experienced no actual fever but felt intense burning pain. The diagnosis was long-term emotional distress leading to liver qi stagnation, qi obstruction, and the resulting internal heat and dryness. This internal heat then attacked the stomach, causing burning sensation, and the stagnant heat ascended along the meridians, resulting in insomnia. She was prescribed a traditional Chinese medicine combination for treating liver qi and qi imbalance, 150-180ml twice daily after meals. Two weeks later, at her follow-up visit, her symptoms had lessened, and she reported feeling better overall. She then continued the treatment for another week, 150-180ml twice daily after meals, to consolidate the therapeutic effect. Following hospital procedures, she underwent six months of outpatient follow-up, with satisfactory recovery.

[0041] Case 3: Brief Medical History Patient Zhu XX, female, 58 years old, reported feeling depressed and crying, burning sensation in the right hypochondrium and back, poor appetite, constipation, lethargy, and lack of activity. Physical examination revealed a sallow complexion, a purplish-dark tongue with a thick, greasy yellow coating, and a wiry, rapid pulse (suggesting liver qi stagnation transforming into heat and spleen deficiency with dampness obstruction). Traditional Chinese medicine diagnosis was liver qi stagnation, with qi and blood stagnation invading the spleen, internal damp-heat accumulation, and poor blood circulation. Blood tests included a complete blood count (to rule out infection), liver biochemistry (such as transaminase testing), and thyroid function tests (to differentiate endocrine disorders). Imaging showed abdominal... Ultrasound or CT / MRI was performed to assess hepatomegaly, rule out hepatitis or tumors, and confirm a diagnosis of liver qi-heat imbalance. A traditional Chinese medicine combination for treating liver qi-heat imbalance was administered, 150-180ml twice daily after meals. A follow-up visit was conducted after 4 weeks; symptoms had lessened, and the patient reported feeling better overall. The traditional Chinese medicine combination for liver qi-heat imbalance was then continued for another two weeks, 150-180ml twice daily after meals, to consolidate the therapeutic effect. Follow-up visits were conducted at the outpatient clinic for six months according to hospital procedures, and the recovery was satisfactory. Case 4: Brief medical history: Patient Li XX, 56 years old, reported recurrent burning pain in the right hypochondrium for 3 years, accompanied by bitter taste in the mouth, dry throat, and constipation resembling sheep pellets. Symptoms worsened with anxiety. Physical examination revealed a red tongue with a thick, greasy yellow coating, and a wiry, slippery, and rapid pulse. There was no jaundice in the sclera. Abdominal palpation revealed tenderness upon percussion of the liver area. Imaging showed liver function tests: ALT 68 U / L (mildly elevated), AST 45 U / L, GGT 110 U / L (suggesting cholestasis). Ultrasound showed increased echogenicity of the liver parenchyma and a portal vein diameter of 12 mm (upper limit of normal). The patient left without treatment after the examination. Upon returning to the hospital, the patient presented with significant new symptoms including fatigue, yellowing of the whites of the eyes, nocturnal diarrhea 3-4 times / day, and a weight loss of 5 kg / 2 months. Imaging revealed hepatitis B surface antigen and antibody tests: HBsAg(+), HBeAg(+), HBV-DNA 5.6×10 IU / ml (high viral load); liver elastography showed CAP 280 dB / m (fatty degeneration), LSM 9.8 kPa (F2 fibrosis); confirmed mid-stage hepatitis; treated with a traditional Chinese medicine combination for liver qi stagnation and heat imbalance, 150-180 ml twice daily after meals, two months later, followed by a follow-up visit according to hospital procedures. Symptoms improved, and subsequent follow-up visits were conducted. After another two months of continued medication, imaging results were good, and a final follow-up visit was conducted. Medication was continued for another two weeks to consolidate the therapeutic effect. The present invention can be well implemented according to the above embodiments. It is worth noting that, based on the above structural design, even if some non-substantial modifications or refinements are made to the present invention to solve the same technical problem, the essence of the technical solution adopted is still the same as that of the present invention, and therefore it should also be within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine combination for treating liver qi stagnation and heat syndrome, characterized in that, Its components are: fennel seeds, dried tangerine peel, cardamom, cassia seeds, mint, and rose petals.

2. The traditional Chinese medicine combination for treating liver qi stagnation and heat disorder according to claim 1, characterized in that, Its components also include celery seeds and coriander seeds.

3. The traditional Chinese medicine combination for treating liver qi stagnation and heat disorder according to claim 1, characterized in that, Its components also include chicory seeds, chrysanthemum, and goji berries.

4. A traditional Chinese medicine combination for treating liver qi stagnation and heat syndrome according to any one of claims 1-3, characterized in that, The weight parts of each component are as follows: 3-10 parts fennel seeds, 5-15 parts goji berries, 10-20 parts chicory seeds, 5-15 parts chrysanthemum, 3-10 parts dried tangerine peel, 3-10 parts celery seeds, 3-10 parts rose petals, 5-15 parts coriander seeds, 5-15 parts cardamom, 5-15 parts cassia seeds, and 5-15 parts mint.

5. A traditional Chinese medicine combination for treating liver qi stagnation and heat syndrome according to any one of claims 1-3, characterized in that, 5 parts fennel seeds, 10 parts goji berries, 15 parts chicory seeds, 5 parts dried tangerine peel, 5 parts celery seeds, 5 parts rose petals, 10 parts coriander seeds, 10 parts cassia seeds, 10 parts chrysanthemum, 10 parts cardamom, and 10 parts mint.

6. The traditional Chinese medicine combination for treating liver qi stagnation disorder according to any one of claims 1-3 is any one of decoction, pill, powder, ointment, elixir, granule, oral liquid, capsule, or tablet.