Traditional Chinese medicine extract with folliculitis treatment effect, preparation method and prepared antibacterial shampoo

Abstract

The invention provides a traditional Chinese medicine extract with a folliculitis treatment effect, a preparation method of the traditional Chinese medicine extract and prepared bacteriostatic shampoo, and belongs to the technical field of daily necessities. The traditional Chinese medicine extract is prepared from the following raw materials in parts by mass: 5 to 20 parts of rhizoma coptidis, 5 to 20 parts of cortex phellodendri, 5 to 20 parts of radix scutellariae, 5 to 20 parts of vinegar frankincense, 5 to 20 parts of vinegar myrrh, 5 to 20 parts of radix et rhizoma rhei, 5 to 20 parts of rhizoma polygoni cuspidati, 5 to 20 parts of radix stemonae and 5 to 20 parts of herba taraxaci. By optimizing the compatibility and extraction process of a traditional Chinese medicine formula and combining the modern preparation technology, the invention aims to provide a traditional Chinese medicine hair washing therapeutic agent which is efficient in permeation, long-acting in bacteriostasis, safe, mild and strong in cleaning power, so as to overcome the defects of current chemical hair washing products in the field of folliculitis treatment.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of daily necessities, in particular to a traditional Chinese medicine extract with folliculitis treatment efficacy, a preparation method and prepared antibacterial shampoo. BACKGROUND

[0002] In recent years, with the intensification of environmental pollution, the increase of life pressure and the widespread existence of bad hair care habits, the incidence of folliculitis has increased significantly. Folliculitis is a common bacterial or fungal infection of the hair follicle, which is clinically manifested as scalp redness, itching, pustules and even hair loss, and seriously affects the quality of life of patients. At present, the mainstream chemical synthetic shampoo products on the market have certain cleaning and anti-dandruff effects, but long-term use may lead to imbalance of scalp microecology, damage to barrier function, and even induce drug resistance, making folliculitis recur. In addition, the common sulfate surfactants, silicon oil and synthetic preservatives (such as methylisothiazolinone) in chemical shampoo may stimulate the scalp and exacerbate inflammatory reactions, making it difficult to meet the dual needs of safety and efficacy of consumers.

[0003] In contrast, traditional Chinese medicine extracts have shown significant advantages in the treatment of folliculitis and scalp care due to their natural, mild and multi-target regulation characteristics. For example, traditional Chinese medicines such as Huangbai, Kushen and Danshen have broad-spectrum antibacterial, anti-inflammatory and hair follicle repair-promoting effects, and are not prone to drug resistance; ingredients such as Cypriesside and Heshouwu can regulate scalp sebum secretion and enhance hair follicle vitality. However, existing traditional Chinese medicine shampoo products still have problems such as low extraction efficiency of active ingredients, poor stability, insufficient transdermal absorption, etc., which limit the therapeutic effect. Therefore, it is of great clinical and market value to develop a shampoo preparation with high-activity traditional Chinese medicine extract as the core, which has the functions of treating folliculitis and caring for the scalp. SUMMARY

[0004] The present application aims to provide a traditional Chinese medicine extract with folliculitis treatment efficacy, a preparation method and prepared antibacterial shampoo, by optimizing the compatibility of traditional Chinese medicine formula and extraction process, combined with modern preparation technology, to provide a traditional Chinese medicine shampoo treatment agent with efficient penetration, long-term antibacterial, safe and mild, and strong cleaning power, to fill the gap of current chemical shampoo products in the field of folliculitis treatment.

[0005] The technical solution of the present application is as follows: The present application provides a traditional Chinese medicine extract with folliculitis treatment efficacy, which is prepared from the following raw materials in parts by mass: Huanglian 5-20 parts, Huangbai 5-20 parts, Huangqi 5-20 parts, vinegar of Olibanum 5-20 parts, vinegar of Myrrh 5-20 parts, Dahuang 5-20 parts, Hujiang 5-20 parts, Baibu 5-20 parts, and Pugongying 5-20 parts.

[0006] Preferably prepared from the following raw materials in parts by weight: 5-15 parts Coptis chinensis, 5-15 parts Phellodendron chinense, 5-15 parts Scutellaria baicalensis, 5-15 parts Vinegar-processed Boswellia carterii, 5-15 parts Vinegar-processed Myrrh, 5-12 parts Rheum palmatum, 5-15 parts Polygonum cuspidatum, 5-15 parts Stemona japonica, and 10-20 parts Taraxacum mongolicum.

[0007] This invention further protects a method for preparing the above-mentioned Chinese herbal extract with therapeutic effects on folliculitis. The method involves adding Coptis chinensis, Phellodendron chinense, Scutellaria baicalensis, vinegar-processed frankincense, vinegar-processed myrrh, rhubarb, Polygonum cuspidatum, Stemona japonica, and Taraxacum mongolicum to 5-10 times their weight of water, soaking for 0.5-2 hours, heating and refluxing for 3-5 hours, filtering, repeating the process 2-3 times, combining the filtrates, and concentrating to a relative density of 1.05-1.15 to obtain the Chinese herbal extract with therapeutic effects on folliculitis.

[0008] This invention further protects the use of the above-mentioned Chinese herbal extract with folliculitis treatment efficacy in the preparation of antibacterial shampoo and drugs for treating folliculitis.

[0009] This invention further protects an antibacterial shampoo prepared from the following raw materials in parts by weight: 40-80 parts of the above-mentioned Chinese herbal extract with folliculitis treatment effect, 10-30 parts of surfactant, 10-20 parts of conditioning agent, and 0.1-0.3 parts of fragrance.

[0010] Preferably prepared from the following raw materials in parts by weight: 55-75 parts of a traditional Chinese medicine extract with therapeutic effects on folliculitis, 20-25 parts of a surfactant, 12-20 parts of a conditioning agent, and 0-0.2 parts of a fragrance.

[0011] As a further improvement of the present invention, the conditioning agent is selected from one or more of dimethyl silicone oil, behenyltrimethylammonium chloride, amino silicone oil, jojoba oil, shea butter, glycerin, and panthenol.

[0012] As a further improvement of the present invention, the surfactant is selected from one or more of the following: ammonium lauryl ether sulfate, cocamidopropyl betaine, cocoyl monoethanolamine, sodium cocoyl glycinate, and novel surfactants; the structural formula of the novel surfactant is shown in Formula I: Formula I; Where n = 6 - 12.

[0013] As a further improvement of the present invention, the surfactant is a mixture of cocamidopropyl betaine and a novel surfactant in a mass ratio of 3-5:7-10; the preparation method of the novel surfactant is as follows: S1. Reaction of tetrachloropentapentane with propylenediamine yields intermediate 1, with the following structure: ; S2. reacting the intermediate 1 and alkyl bromide to prepare intermediate 2, as shown in the structure below: ; S3. reacting the intermediate 2 and 1,3-propanesultone to prepare the product.

[0014] As a further improvement of the present application, the molar ratio of the tetrachloro quaternary pentane to propylene diamine in step S1 is 1-1.1:4; the molar ratio of the intermediate 1 to alkyl bromide in step S2 is 1-1.1:4, and the alkyl bromide is at least one selected from 1-bromohexane, 1-bromoheptane, 1-bromooctane, 1-bromononane, 1-bromodecane, 1-bromoundecane and 1-bromododecane; the molar ratio of the intermediate 2 to 1,3-propanesultone in step S3 is 1-1.1:8.

[0015] As a further improvement of the present application, the essence is selected from one or more of mint essential oil, tea tree essential oil, lavender essential oil, citrus essential oil, rosemary essential oil and sandalwood essential oil.

[0016] The present application further protects a preparation method of the above-mentioned bacteriostatic shampoo, comprising the following steps: mixing traditional Chinese medicine extract with hair folliculitis treatment efficacy, surfactant, conditioning agent and essence in proportion, heating to 40-60 DEG C to completely dissolve, homogenizing at 10000-15000 r / min for 10-20 min, and then dispensing to obtain the product.

[0017] The present application has the following beneficial effects: The present application optimizes the compatibility and extraction process of traditional Chinese medicine prescription, and combines modern preparation technology, aiming to provide a traditional Chinese medicine shampoo treatment agent with high penetration, long-term bacteriostatic effect, safety, mildness and strong cleaning power, so as to fill the deficiency of current chemical shampoo products in the field of hair folliculitis treatment.

[0018] The traditional Chinese medicine extract in the present application is prepared from Huanglian, Huangbai, Huangqi, vinegar frankincense, vinegar myrrh, Dahuang, Huzhang, Baibu and Pugongying. Berberine (Huanglian) derived from Huanglian, berberine and wobai ketone derived from Huangbai, and baicalin derived from Huangqi all have broad-spectrum antibacterial activity and can effectively inhibit the growth of scalp bacteria under synergistic effect. The vinegar frankincense and vinegar myrrh can improve the scalp microcirculation and promote the supply of hair follicle nutrition after being pickled to enhance the effects of promoting blood circulation to remove blood stasis and promoting muscle regeneration. Dahuang contains anthraquinone components and has the effects of astringency, swelling and blood stasis, which can reduce the permeability of capillaries and assist in oil control. The active component of Huzhang, huzhang glycoside, can inhibit inflammatory response and synergistically enhance the anti-inflammatory effect. Baibu extract has inhibitory effect on scalp mites and other parasites, and can relieve itching symptoms. Pugongying contains pugongying sterols and chlorogenic acid, and has the effects of clearing heat and detoxifying, swelling and knotting, which can synergistically enhance the overall anti-inflammatory effect. The traditional Chinese medicine extract in the present application is pure traditional Chinese medicine extract, which is safe and non-irritating to the skin, has the effect of treating hair folliculitis, and has good bacteriostatic, anti-dandruff and anti-itching effects.

[0019] The present application selects an amphoteric surfactant and a prepared high-activity anionic surfactant (a new surfactant) for compounding, wherein the positive charge group in the amphoteric surfactant molecule and the negative charge group of the anionic surfactant produce electrostatic attraction, significantly weakening the repulsion between the same charges and enhancing the interface film strength. The new surfactant has more alkyl chains and anionic groups, and is more likely to form mixed micelles with the amphoteric surfactant, so that the critical micelle concentration is significantly reduced, and the surface tension is also significantly reduced, thereby significantly improving the foam height and stability, thereby producing abundant and dense foam, enhancing the cleaning ability, reducing the adsorption of anions to the scalp protein, relieving the dry and tight feeling, being more mild than the pure anionic system, having better biological safety, not being easy to cause skin sensitization or irritation, and being able to obtain better cleaning and use effect at a lower concentration.

[0020] In addition, the preparation method of the new surfactant of the present application is simple, the reaction conditions are mild, and the yield is high. In addition, the new surfactant has a good scalp absorption promoting effect. The alkyl chain can interact with the polar head region of the intercellular lipid of the stratum corneum, change the hydrogen bond force and ionic bond force, make the lipid arrangement from order to disorder, significantly increase the lipid fluidity, and the anionic group interacts with the keratin protein, removes part of the keratin structure, thereby significantly improving the transdermal absorption rate of the scalp to the traditional Chinese medicine extract, and greatly exerting the drug efficacy. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present application will be described below in a clear and complete manner. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0022] Preparation Example 1: New surfactant The synthesis route is as follows: ; The preparation method is as follows: S1. 0.1 mol of tetrachloro quaternary pentane is added to 220 mL of ethanol, 0.4 mol of propylene diamine is added, 1 mol of triethylamine is added, and the mixture is stirred and refluxed for 20 h. The solvent is removed under reduced pressure, filtered, washed, and dried to obtain an intermediate 1; ESI-MS calculated value: C 17 H 45 N8(M+H) + 361.58, measured value: 361.6, yield: 88%. NMR result: 1H NMR (300 MHz, CDC13) δ 2.65 (t, 8H), 2.47 (t, 8H), 2.41 (s, 8H), 2.0 (br, 12H), 1.64 (m, 8H).

[0023] S2. 0.1 mol of intermediate 1 and 0.4 mol of 1-bromohexane were added to 200 mL of acetonitrile, 1 mol of triethylamine was added, the reaction was stirred under heating reflux for 7 h, the solvent was removed under reduced pressure, filtered, washed, and dried to obtain intermediate 2; ESI-MS calculated value: C 41 H 93 N8(M+H) + 698.22, actual value: 698.2, yield 84%. NMR results: 1 H NMR (300 MHz, CDC13) δ 2.55-2.59 (m, 12H), 2.49 (s, 8H), 2.2 (br, 8H), 1.51 (m, 8H), 1.25-1.37 (m, 16H), 0.91 (t, 12H).

[0024] S3. 0.1 mol of intermediate 2 and 0.8 mol of 1,3-propanesultone were added to 200 mL of methanol, stirred under heating reflux for 20 h under nitrogen protection, filtered under reduced pressure, the solid was recrystallized with ethanol / cyclohexane (volume ratio 1:5), filtered, washed, and dried to obtain the product. ESI-MS calculated value: C 65 H 133 N8Na8O 24 S8(M+H) + 1851.22, actual value: 1851.2, yield 71%. Infrared spectrum analysis: 2917 cm -1 as -CH3 and -CH2- stretching vibration absorption peaks, 1225 cm -1 and 1187 cm -1 as C-N stretching vibration peaks, 1188 cm -1 and 1047 cm -1 as -SO3 - stretching vibration peaks of O-S, 721 cm -1 as the absorption peaks of the hydrophobic chain -(CH2)n.

[0025] Preparation of a new surfactant The preparation method is as follows: S1. 0.11 mol of tetrachloro pentaerythritol was added to 220 mL of ethanol, 0.4 mol of propylenediamine was added, 1 mol of triethylamine was added, the reaction was stirred under heating reflux for 28 h, the solvent was removed under reduced pressure, filtered, washed, and dried to obtain intermediate 1; yield 91%.

[0026] S2. 0.11 mol of intermediate 1 and 0.4 mol of 1-bromohexane were added into 200 mL of acetonitrile, 1 mol of triethylamine was added, the reaction was stirred under heating reflux for 10 h, the solvent was removed under reduced pressure, filtration, washing, drying, to prepare intermediate 2; the yield was 86%.

[0027] S3. 0.11 mol of intermediate 2 and 0.8 mol of 1,3-propanesultone were added into 200 mL of methanol, the reaction was stirred under heating reflux for 28 h under nitrogen protection, filtration under reduced pressure, the solid was recrystallized with ethanol / cyclohexane (volume ratio 1:5), filtration, washing, drying, to prepare the product. The yield was 73%.

[0028] Preparation Example 3 Novel surfactant The preparation method is as follows: S1. 0.105 mol of tetra-chloro-pentaerythritol was added into 220 mL of ethanol, 0.4 mol of propylenediamine was added, 1 mol of triethylamine was added, the reaction was stirred under heating reflux for 24 h, the solvent was removed under reduced pressure, filtration, washing, drying, to prepare intermediate 1; the yield was 90%.

[0029] S2. 0.105 mol of intermediate 1 and 0.4 mol of 1-bromododecane were added into 200 mL of acetonitrile, 1 mol of triethylamine was added, the reaction was stirred under heating reflux for 8 h, the solvent was removed under reduced pressure, filtration, washing, drying, to prepare intermediate 2; the yield was 83%.

[0030] S3. 0.105 mol of intermediate 2 and 0.8 mol of 1,3-propanesultone were added into 200 mL of methanol, the reaction was stirred under heating reflux for 24 h under nitrogen protection, filtration under reduced pressure, the solid was recrystallized with ethanol / cyclohexane (volume ratio 1:5), filtration, washing, drying, to prepare the product. The yield was 67%.

[0031] Test Example 1 A series of solutions with different concentrations were prepared by using the products prepared in Preparation Examples 1-3 and sodium dodecyl sulfonate, and the surface tension of each solution was measured at (25±0.1)℃, and a γ-lgc curve was drawn, and the concentration corresponding to the inflection point on the curve was the critical micelle concentration (CMC). The results are shown in Table 1.

[0032] Table 1

[0033] As shown in the above table, the novel surfactants prepared in Preparation Examples 1-3 have lower critical micelle concentration and surface tension.

[0034] Test Example 2 The product prepared in Preparation Example 1-3 of the present application and sodium dodecyl sulfonate are formulated into a 1 g / L aqueous solution. 10 mL of the aqueous solution is poured into a 100 mL graduated cylinder with a stopper, and after being shaken vigorously up and down for 25 times, the foam height at this time is recorded. After standing for 5 min, the foam height is recorded again. The test is repeated for 3 times, and the average value is taken.

[0035] The results are shown in Table 2.

[0036]

[0037] From the above table, it can be seen that the novel surfactant prepared in Preparation Example 1-3 of the present application has good foaming performance.

[0038] Example 1: The present example provides a traditional Chinese medicine extract with folliculitis treatment efficacy.

[0039] It is prepared from the following raw materials in parts by mass: Coptis 10 parts, Amur cork-tree 13 parts, Huangqi 10 parts, vinegar olibanum 10 parts, vinegar myrrh 10 parts, Rhubarb 8 parts, Giant knotweed 10 parts, Stemona 13 parts, Dandelion 15 parts.

[0040] The preparation method is as follows: Coptis, Amur cork-tree, Huangqi, vinegar olibanum, vinegar myrrh, Rhubarb, Giant knotweed, Stemona, and Dandelion are added into 8 times mass of water, soaked for 1 h, heated to reflux for 4 h, filtered, repeated for 3 times, the filtrates are combined, concentrated to a relative density of 1.1, to obtain the traditional Chinese medicine extract with folliculitis treatment efficacy.

[0041] Example 2: Compared with Example 1, the difference lies in that the raw material ratio is different.

[0042] It is prepared from the following raw materials in parts by mass: Coptis 10 parts, Amur cork-tree 10 parts, Huangqi 8 parts, vinegar olibanum 9 parts, vinegar myrrh 9 parts, Rhubarb 8 parts, Giant knotweed 9 parts, Stemona 10 parts, Dandelion 12 parts.

[0043] Example 3: Compared with Example 1, the difference lies in that the raw material ratio is different.

[0044] It is prepared from the following raw materials in parts by mass: Coptis 10 parts, Amur cork-tree 13 parts, Huangqi 10 parts, vinegar olibanum 8 parts, vinegar myrrh 8 parts, Rhubarb 8 parts, Giant knotweed 10 parts, Stemona 10 parts, Dandelion 12 parts.

[0045] Example 4: Compared with Example 1, the difference lies in that the raw material ratio is different.

[0046] It is prepared from the following raw materials in parts by mass: Coptis 10 parts, Amur cork-tree 13 parts, Huangqi 10 parts, vinegar olibanum 10 parts, vinegar myrrh 10 parts, Rhubarb 8 parts, Giant knotweed 10 parts, Stemona 13 parts, Dandelion 15 parts.

[0047] Example 5: The present example provides a bacteriostatic shampoo, which is prepared from the following raw materials in parts by mass: the traditional Chinese medicine extract with folliculitis treatment efficacy prepared in Example 1 40 parts, a surfactant 10 parts, amino silicon oil 10 parts, lavender essential oil 0.1 part. The surfactant is a mixture of cocamidopropyl betaine and the novel surfactant prepared in Preparation Example 1, with a mass ratio of 3:7.

[0048] The preparation method comprises the following steps: mixing the traditional Chinese medicine extract with folliculitis treatment efficacy, the surfactant, the amino silicon oil, and the fragrance in proportion, heating to 40°C to completely dissolve, homogenizing at 10000 r / min for 10 min, and then dispensing to obtain the product.

[0049] Example 6: The present example provides a bacteriostatic shampoo, which is prepared from the following raw materials in parts by mass: the traditional Chinese medicine extract with folliculitis treatment efficacy prepared in Example 2 80 parts, a surfactant 30 parts, dimethyl silicon oil 20 parts, citrus essential oil 0.3 part. The surfactant is a mixture of cocamidopropyl betaine and the novel surfactant prepared in Preparation Example 2, with a mass ratio of 5:10.

[0050] The preparation method comprises the following steps: mixing the traditional Chinese medicine extract with folliculitis treatment efficacy, the surfactant, the dimethyl silicon oil, and the fragrance in proportion, heating to 60°C to completely dissolve, homogenizing at 15000 r / min for 20 min, and then dispensing to obtain the product.

[0051] Example 7: The present example provides a bacteriostatic shampoo, which is prepared from the following raw materials in parts by mass: the traditional Chinese medicine extract with folliculitis treatment efficacy prepared in Example 3 60 parts, a surfactant 20 parts, behenyl trimethyl ammonium chloride 15 parts, mint essential oil 0.2 part. The surfactant is a mixture of cocamidopropyl betaine and the novel surfactant prepared in Preparation Example 3, with a mass ratio of 4:9.

[0052] The preparation method comprises the following steps: mixing the traditional Chinese medicine extract with folliculitis treatment efficacy, the surfactant, the behenyl trimethyl ammonium chloride, and the fragrance in proportion, heating to 50°C to completely dissolve, homogenizing at 12000 r / min for 15 min, and then dispensing to obtain the product.

[0053] Example 8: Compared with Example 7, the difference lies in that the traditional Chinese medicine extract with folliculitis treatment efficacy is prepared in Example 4.

[0054] Example 9: Compared with Example 7, the difference lies in that the surfactant is single cocamidopropyl betaine.

[0055] Example 10: Compared with Example 7, the difference is that the surfactant is a single new surfactant prepared in Preparation Example 3.

[0056] Comparative Example 1 Compared with Example 7, the difference is that the new surfactant is replaced by sodium dodecyl sulfonate.

[0057] Comparative Example 2 Compared with Example 7, the difference is that cocamide propyl betaine is replaced by perpass O-7.

[0058] Comparative Example 3 Compared with Example 7, the difference is that no traditional Chinese medicine extract with hair folliculitis treatment efficacy is added.

[0059] Test Example 3 The bacteriostatic shampoo prepared in Examples 5-10 and Comparative Examples 1-3 is diluted with water to prepare a sample solution of 1 mg / mL. According to the test method for bacteriostatic performance of GB 15979-2024 Appendix CC4 Dissolution Anti (bacteriostatic) product bacteriostatic performance test method. The Malassezia 24h slant culture is washed with PBS to prepare a bacterial suspension, 100 μL of which is added to each sample solution, mixed uniformly, and then timing starts. After 5 minutes of action, 0.5 mL of sample solution is added to a test tube containing 5 mL of PBS with a sterile forceps, mixed thoroughly, and then 0.5 mL of the diluted solution is taken and placed on a plate with 15 mL of nutrient agar medium cooled to 40-45℃. The plate is rotated to make the agar evenly distributed, and after the agar is solidified, the plate is turned over and cultured at (35±2)℃ for 48 hours. The viable bacterial colonies are counted. The results are shown in Table 3.

[0060] Bacteriostatic rate = (average number of colonies of control sample - average number of colonies of test sample) / average number of colonies of control sample x 100%.

[0061] The evaluation standard is that the bacteriostatic rate is ≥50%-90%, the product has bacteriostatic effect, and the bacteriostatic rate is ≥90%, the product has strong bacteriostatic effect.

[0062] Table 3

[0063] As can be seen from the above table, the bacteriostatic shampoo prepared in Examples 5-8 has a higher bacteriostatic rate.

[0064] Test Example 4 The bacteriostatic shampoo prepared in Examples 5-10 and Comparative Examples 1-3 is subjected to sensory evaluation, with a full score of 10 points. The evaluation team consists of 20 people with certain experience in shampoo soap sensory evaluation. The average value of each group is taken, and the first decimal place is retained. The results are shown in Table 5.

[0065] Table 4

[0066] Table 5

[0067] From the above table, the comprehensive sensory effect of the bacteriostatic shampoo prepared in Examples 5-8 is better.

[0068] Test Example 5 90 volunteers were randomly divided into 9 groups, namely Examples 5-10 and Comparative Examples 1-3, and the corresponding bacteriostatic shampoo was used every other day. On the 0th and 14th days, follow-up was conducted, and the hair loss count and sebum content of each subject were tested before use and at each follow-up. Environmental conditions: temperature 21±1℃, relative humidity 50±5%.

[0069] Sebum content analysis.

[0070] The sebum content of the scalp was measured by Sebumeter SM815 (Courage+Khazaka Company, Germany), and the test site was the top of the head. Each subject was tested 3 times, and the average value was taken. The subjects needed to wash their scalps and dry them for 24 hours before testing to avoid external oil interference. The greater the sebum mass, the greater the sebum content. The smaller the value, the lower the sebum content, and the better the oil control effect of the product.

[0071] Sebum content reduction rate (%) = (sebum content measured on the 14th day - sebum content measured on the 0th day) / sebum content measured on the 0th day x 100% Hair loss count.

[0072] The hair loss of each subject was collected with a screen during shampooing and counted.

[0073] Hair loss improvement rate (%) = (hair loss on the 0th day - hair loss on the 14th day) / hair loss on the 0th day x 100% The results are shown in Table 6.

[0074] Table 6

[0075] From the above table, the bacteriostatic shampoo prepared in Examples 5-8 has a good sebum improvement effect on the scalp and can prevent hair loss.

[0076] The above description is only a preferred embodiment of the present application and is not intended to limit the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. A traditional Chinese medicine extract with therapeutic effects on folliculitis, characterized in that, It is prepared from the following raw materials in parts by weight: Coptis chinensis 5-20 parts, Phellodendron chinense 5-20 parts, Scutellaria baicalensis 5-20 parts, Vinegar-processed Boswellia carterii 5-20 parts, Vinegar-processed Myrrh 5-20 parts, Rheum palmatum 5-20 parts, Polygonum cuspidatum 5-20 parts, Stemona japonica 5-20 parts, and Taraxacum mongolicum 5-20 parts.

2. A method for preparing a traditional Chinese medicine extract with folliculitis treatment efficacy as described in claim 1, characterized in that, Add Coptis chinensis, Phellodendron chinense, Scutellaria baicalensis, vinegar-processed frankincense, vinegar-processed myrrh, rhubarb, Polygonum cuspidatum, Stemona japonica, and Taraxacum mongolicum to 5-10 times their weight of water, soak for 0.5-2 hours, heat under reflux for 3-5 hours, filter, repeat the operation 2-3 times, combine the filtrates, and concentrate to a relative density of 1.05-1.15 to obtain a traditional Chinese medicine extract with therapeutic effects on folliculitis.

3. The application of a traditional Chinese medicine extract with folliculitis treatment efficacy as described in claim 1 in the preparation of antibacterial shampoo and medicine for treating folliculitis.

4. An antibacterial shampoo, characterized in that, It is prepared from the following raw materials in parts by mass: 40-80 parts of the Chinese herbal extract with folliculitis treatment efficacy as described in claim 1, 10-30 parts of surfactant, 10-20 parts of conditioning agent, and 0.1-0.3 parts of fragrance.

5. The antibacterial shampoo according to claim 4, characterized in that, The conditioning agent is selected from one or more of dimethyl silicone oil, behenyltrimethylammonium chloride, amino silicone oil, jojoba oil, shea butter, glycerin, and panthenol.

6. The antibacterial shampoo according to claim 4, characterized in that, The surfactant is selected from one or more of the following: ammonium lauryl ether sulfate, cocamidopropyl betaine, cocoyl monoethanolamine, sodium cocoyl glycinate, and novel surfactants; the structural formula of the novel surfactant is shown in Formula I: Formula I; Where n = 6 - 12.

7. The antibacterial shampoo according to claim 6, characterized in that, The surfactant is a mixture of cocamidopropyl betaine and a novel surfactant in a mass ratio of 3-5:7-10; the preparation method of the novel surfactant is as follows: S1. Reaction of tetrachloropentapentane with propylenediamine yields intermediate 1, with the following structure: ; S2. Intermediate 1 is reacted with an alkyl bromide to obtain intermediate 2, with the following structure: ; S3. Intermediate 2 and 1,3-propanesulfonic acid lactone were reacted to obtain the product.

8. The antibacterial shampoo according to claim 7, characterized in that, In step S1, the molar ratio of tetrachloropentapentane to propylenediamine is 1-1.1:4; in step S2, the molar ratio of intermediate 1 to alkyl bromide is 1-1.1:4, wherein the alkyl bromide is selected from at least one of 1-bromohexane, 1-bromoheptane, 1-bromooctane, 1-bromononane, 1-bromodecane, 1-bromoundecane, and 1-bromododecane; and in step S3, the molar ratio of intermediate 2 to 1,3-propanesulfonic acid lactone is 1-1.1:

8.

9. The antibacterial shampoo according to claim 4, characterized in that, The fragrance is selected from one or more of peppermint essential oil, tea tree essential oil, lavender essential oil, citrus essential oil, rosemary essential oil, and sandalwood essential oil.

10. A method for preparing an antibacterial shampoo as described in any one of claims 4-9, characterized in that, The process includes the following steps: mixing Chinese herbal extracts with folliculitis treatment effects, surfactants, conditioning agents, and fragrances in a certain proportion, heating to 40-60℃ to dissolve completely, homogenizing at 10000-15000r / min for 10-20min, and then dispensing to obtain the product.

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