Analysis device, parameter determination device, and parameter analysis system

Abstract

According to the analysis device, the parameter determination device and the parameter analysis system provided by the embodiment of the invention, the analysis device integrates the capture assembly, the magnetic field generation assembly and the induction assembly, so that complex physical connection is avoided, the integration level of the device is greatly improved, and the overall size is effectively reduced; the mobility and mass-to-charge ratio analysis of ions can be realized based on the analysis device.

Description

Technical Field

[0001] This application belongs to the field of analytical chemistry instrument technology, and in particular relates to an analytical device, a parameter determination device, and a parameter analysis system. Background Technology

[0002] Mass spectrometry (MS) and ion mobility spectrometry (IMS) are two core technologies for qualitative analysis of substances. Mass spectrometry identifies ions by measuring their mass-to-charge ratio (m / z) under high vacuum, while ion mobility spectrometry typically operates at higher pressures (such as atmospheric pressure or low vacuum) with gas flow, distinguishing ions by measuring their mobility (K) or collision cross section (CCS). These two technologies complement each other and have wide applications in environmental monitoring, drug discovery, and public safety. To obtain ion mobility and mass-to-charge ratio information, the mainstream approach is a tandem structure, physically connecting a separate ion mobility spectrometry device to a separate mass spectrometer via an interface. However, this physical connection method suffers from low integration and large size. Summary of the Invention

[0003] In view of this, embodiments of this application provide an analysis device, a parameter determination device, and a parameter analysis system, which can realize the analysis of ion mobility and mass-to-charge ratio based on the analysis device. Compared with the existing technology, it is smaller in size and has a higher degree of integration.

[0004] In a first aspect, embodiments of this application provide an analysis apparatus, including: A trapping assembly for trapping different ions at different locations along the axial direction; A magnetic field generating component is used to generate a magnetic field along the axial direction, causing the ions to gyratory motion; A sensing component, disposed inside the capture component, is used to detect the current sensing signal generated when ions gyrate within the capture component.

[0005] In some embodiments, the trapping assembly includes: a plurality of annular electrodes arranged axially; and a radio frequency voltage source connected to each annular electrode and used to apply radio frequency voltages of opposite phase to the annular electrodes, so that the trapping assembly provides radial confinement of ions in the trapping assembly.

[0006] In some embodiments, the capture component further includes: A DC voltage source is connected to each ring electrode and is used to apply a DC voltage to each ring electrode to form an electric field gradient or potential well that increases along the axial direction.

[0007] In some embodiments, the analysis apparatus further includes: A data processing component is used to obtain the position and cyclotron frequency of ions based on the current sensing signal acquired by the sensing component, and to obtain the mobility and mass-to-charge ratio of ions based on the position and the cyclotron frequency.

[0008] In some embodiments, the analysis apparatus further includes: A vacuum and air intake system is used to provide an environment with a preset vacuum level and / or an input airflow to the capture assembly.

[0009] In some embodiments, the analysis apparatus further includes: A pressure sensor is used to detect the airflow pressure within the capture assembly in order to control the vacuum and intake system; A flow controller is used to control the airflow input from the vacuum and intake system to the capture component.

[0010] In some embodiments, the sensing component includes any one of a ring-shaped induction coil, a sector-shaped induction electrode, and an arc-shaped electrode.

[0011] In some embodiments, when the sensing component is an arc-shaped electrode, the arc-shaped electrode includes: a 90° arc-shaped electrode, and the number of the 90° arc-shaped electrodes is four. The four 90° arc-shaped electrodes are disposed on the inner wall of the corresponding annular electrode and distributed in four quadrants.

[0012] Secondly, embodiments of this application provide a parameter determination method, including: The analytical device described in any one of the first aspects is controlled based on the control method corresponding to the target analysis mode, wherein the target analysis mode includes: mobility spectrum analysis mode or mass spectrometry analysis mode; Acquire the current sensing signal detected by the sensing component of the analysis device; The parameters corresponding to the target analysis mode are determined based on the current sensing signal. When the target analysis mode is a migration spectrum analysis mode, the parameter corresponding to the migration spectrum analysis mode is the ion mobility. When the target analysis mode is a mass spectrometry analysis mode, the parameter corresponding to the mass spectrometry analysis mode is the ion mass-to-charge ratio.

[0013] In some embodiments, controlling the analysis device according to any one of the first aspects based on the control method corresponding to the target analysis mode includes: Gas is introduced into the capture assembly to achieve a first preset vacuum level and form an axial airflow. The trapping assembly is controlled to generate a reverse electric field gradient opposite to the axial airflow and to provide radial confinement to the ions, so that ions with different mobilities are separated and held in the axial direction, and the magnetic field generating assembly is controlled to generate a magnetic field along the axial direction. The capture component is controlled to operate in a preset working mode, wherein operating in the preset working mode includes: when the i-th ring electrode is closed, the ions at the position corresponding to the i-th ring electrode undergo cycloidal motion, the sensing component acquires the current sensing signal of the ions at the position corresponding to the i-th ring electrode, and when the current sensing signal of the i-th ring electrode is acquired, the i-th ring electrode is controlled to operate, and the (i+1)-th ring electrode is controlled to close, and the sensing component acquires the current sensing signal of the ions at the position corresponding to the (i+1)-th ring electrode, where i is a positive integer greater than or equal to 1.

[0014] In some embodiments, determining the parameters corresponding to the target analysis mode based on the current sensing signal includes: The electrode positions corresponding to each peak value are determined based on the current sensing signal. The ion mobility is determined based on the electrode position and a pre-established calibration curve, wherein the calibration curve includes the correspondence between the mobility of each ion and the electrode position under the reverse electric field gradient.

[0015] In some embodiments, the method further includes: If interfering ions are determined to be present based on ion mobility, the voltage information of the ring electrode at the electrode position corresponding to the interfering ion is adjusted to remove the interfering ion.

[0016] In some embodiments, controlling the analysis device according to any one of the first aspects based on the control method corresponding to the target analysis mode includes: When the target analysis mode is mass spectrometry analysis mode, the environment inside the capture component is evacuated to a second preset vacuum level; The trapping component is controlled to form a potential well and provide radial confinement to the ions, and the magnetic field generating component is controlled to generate a magnetic field along the axial direction, wherein, in the case of forming a potential well, the ions are trapped within the potential well. The voltage of each ring electrode in the capture assembly is reduced to decrease the radial confinement of ions by the capture assembly. When the radial confinement of ions by the capture assembly is reduced, the ions undergo cyclotron motion. The sensing assembly synchronously acquires the current sensing signal of ions at the corresponding positions of each ring electrode.

[0017] In some embodiments, controlling the analysis device according to any one of the first aspects based on the control method corresponding to the target analysis mode includes: When the target analysis mode is mass spectrometry analysis mode, the environment inside the capture component is evacuated to a second preset vacuum level; Control the capture component to form a potential well; The magnetic field generating component is controlled to generate a magnetic field along the axis so that the ions rotate synchronously, and the sensing component synchronously collects the current sensing signals of the ions at the corresponding positions of each ring electrode in the capturing component.

[0018] In some embodiments, determining the parameters corresponding to the target analysis mode based on the current sensing signal includes: The current sensing signals of ions at corresponding positions of each ring electrode are converted into the frequency domain to obtain the cyclotron frequency spectrum of the ions. The mass-to-charge ratio of each ion is calculated based on the cyclotron frequency spectrum.

[0019] In some embodiments, the method further includes: Given the mass-to-charge ratio and mobility of ions, the mass-to-charge ratio and mobility of the same ion are correlated, and a two-dimensional spectrum is generated, which includes the mass-to-charge ratio and mobility of the ion.

[0020] Thirdly, embodiments of this application provide a parameter determination device, comprising: A control module is used to control the analytical device described in any one of the first aspects based on the control method corresponding to the target analysis mode, wherein the target analysis mode includes: migration spectrum analysis mode or mass spectrometry analysis mode; The acquisition module is used to acquire the current sensing signal detected by the sensing component of the analysis device; The parameter determination module is used to determine the parameters corresponding to the target analysis mode based on the current sensing signal. When the target analysis mode is a migration spectrum analysis mode, the parameter corresponding to the migration spectrum analysis mode is the ion mobility. When the target analysis mode is a mass spectrometry analysis mode, the parameter corresponding to the mass spectrometry analysis mode is the ion mass-to-charge ratio.

[0021] Fourthly, embodiments of this application provide an electronic device, including a memory, a processor, and a computer program stored in the memory and executable on the processor, wherein the processor executes the computer program to implement the method described in any of the above-mentioned embodiments.

[0022] Fifthly, embodiments of this application provide a parameter analysis system, comprising: the analysis device described in any one of the first aspects, wherein the parameter analysis system is capable of obtaining ion mobility or mass-to-charge ratio.

[0023] Sixthly, embodiments of this application provide a computer-readable storage medium storing a computer program that, when executed by a processor, implements the method described in any of the preceding claims.

[0024] In a seventh aspect, embodiments of this application provide a computer program product that, when run on a terminal device, causes an electronic device to execute any of the methods described above.

[0025] The beneficial effects of the embodiments in this application compared with the prior art are: The present application provides an analytical device that integrates a capture component, a magnetic field generating component, and a sensing component into one unit, avoiding complex physical connections, greatly improving the integration of the device, effectively reducing the overall volume, and enabling the analysis of ion mobility and mass-to-charge ratio based on the analytical device. Attached Figure Description

[0026] To more clearly illustrate the technical solutions in the embodiments of this application, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0027] Figure 1 This is a schematic diagram of the structure of an analysis device provided in an embodiment of this application; Figure 2 A schematic diagram illustrating the implementation process of a parameter determination method provided for the purposes of this application; Figure 3 This application provides a schematic diagram of the implementation process of step S201. Figure 4 This application provides a schematic diagram of an ion-dwelling position according to an embodiment of the present application; Figure 5 A schematic diagram of ion cyclotron motion provided in an embodiment of this application; Figure 6 This is a schematic diagram of the structure of a parameter determination device provided in an embodiment of this application; Figure 7 This is a schematic diagram of the structure of an electronic device provided in an embodiment of this application. Detailed Implementation

[0028] In the following description, specific details such as particular system architectures and techniques are set forth for illustrative purposes and not for limitation, in order to provide a thorough understanding of the embodiments of this application. However, those skilled in the art will understand that this application may also be implemented in other embodiments without these specific details. In other instances, detailed descriptions of well-known systems, apparatuses, circuits, and methods have been omitted so as not to obscure the description of this application with unnecessary detail.

[0029] It should be understood that, when used in this application specification and the appended claims, the term "comprising" indicates the presence of the described features, integrals, steps, operations, elements and / or components, but does not exclude the presence or addition of one or more other features, integrals, steps, operations, elements, components and / or a collection thereof.

[0030] It should also be understood that the term “and / or” as used in this application specification and the appended claims means any combination of one or more of the associated listed items and all possible combinations, and includes such combinations.

[0031] As used in this application specification and the appended claims, the term "if" may be interpreted, depending on the context, as "when," "once," "in response to determination," or "in response to detection." Similarly, the phrases "if determined" or "if detected" may be interpreted, depending on the context, as "once determined," "in response to determination," "once detected," or "in response to detection."

[0032] Furthermore, in the description of this application and the appended claims, the terms "first," "second," "third," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0033] References to "one embodiment" or "some embodiments" in this specification mean that one or more embodiments of this application include a specific feature, structure, or characteristic described in connection with that embodiment. Therefore, the phrases "in one embodiment," "in some embodiments," "in other embodiments," "in still other embodiments," etc., appearing in different parts of this specification do not necessarily refer to the same embodiment, but rather mean "one or more, but not all, embodiments," unless otherwise specifically emphasized.

[0034] Based on the problems in related technologies, embodiments of this application provide an analysis device. Figure 1 This is a schematic diagram of the structure of an analysis device provided in an embodiment of this application, such as... Figure 1As shown, it includes: a capture component 100 for capturing different ions at different positions along the axial direction; a magnetic field generating component 200 for generating a magnetic field along the axial direction to cause the ions to gyrate; and a sensing component 300 disposed inside the capture component 100 for detecting the current sensing signal generated when the ions gyrate in the capture component.

[0035] In this embodiment, the magnetic field generating component can be located either outside or inside the capturing component. Figure 1 In this example, taking a component located outside the capture assembly, the magnetic field generating assembly can employ structures such as electromagnets or permanent magnets to generate the magnetic field. The magnetic field generating assembly produces a uniform magnetic field along the axial direction. When ions lose their radial binding force, they experience a Lorentz force within the magnetic field. According to the Lorentz force formula F=qvB (where q is the ion charge, v is the ion velocity, and B is the magnetic field strength), the ions will undergo circular motion, or cyclotron motion, in a plane perpendicular to both the magnetic field direction and the ion's direction of motion. By detecting information such as the cyclotron frequency of the ions, their properties, such as their mass-to-charge ratio, can be further analyzed.

[0036] In this embodiment, the sensing component is disposed inside the capture component, specifically on the inner wall of the capture component. When the capture component is composed of ring electrodes, the sensing component can be disposed on the inner wall of each ring electrode. The sensing component can employ structures such as induction coils or electrode sheets. When ions move within the capture component, a current sensing signal is generated in the sensing component. These signals contain information about the movement of ions, such as their position, velocity, and quantity. By analyzing and processing these sensing signals, relevant ion characteristics can be obtained. For example, the ion mobility and mass-to-charge ratio can be inferred by detecting the current sensing signal.

[0037] In some embodiments, the analysis apparatus further includes: a data processing component, configured to acquire the position and cyclotron frequency of ions based on a current sensing signal acquired by the sensing component, and to acquire the mobility and mass-to-charge ratio of ions based on the position and the cyclotron frequency.

[0038] In some embodiments, the analytical apparatus further includes a vacuum and air intake system for providing a preset vacuum environment and / or input airflow to the capture assembly. The vacuum and air intake system may include components such as a vacuum pump, air intake valves, and pipes. The vacuum pump is used to extract air from the capture assembly to create a vacuum environment; the air intake valves and pipes are used to control the input airflow. When providing a preset vacuum environment, the vacuum pump can extract air from the capture assembly to achieve the required vacuum level. Different analytical needs may require different vacuum levels. For example, in mass spectrometry, a higher vacuum level can reduce collisions between ions and gas molecules, improving analytical accuracy. The input airflow can carry ions into the array or be used to change the motion state of ions within the array. For example, in ion mobility spectrometry, the airflow can help ions migrate in the axial direction, thereby achieving ion separation and detection.

[0039] The analytical apparatus provided in this application integrates a capture component, a magnetic field generating component, a sensing component, and a vacuum and gas intake system, enabling multiple analytical modes. For example, by adjusting the voltage of the capture component and the parameters of the vacuum and gas intake system, switching between ion mobility spectrometry (IMS) mode and mass spectrometry mode can be achieved. IMS mode can be used to separate and detect ions with different mobilities, while mass spectrometry mode can be used to determine the mass-to-charge ratio of ions, thus providing more comprehensive information for analysis. The structure of the capture component and the rational layout of the various components make the overall structure of the device relatively compact. This compact design reduces the size and weight of the device, facilitating integration into other devices or portable design.

[0040] In this embodiment, the trapping assembly 100 includes a plurality of ring electrodes and a radio frequency voltage source, the ring electrodes being arranged axially. The radio frequency voltage source is connected to each ring electrode and is used to apply a radio frequency voltage with opposite phase to the ring electrodes, so that the trapping assembly provides radial confinement to ions in the trapping assembly.

[0041] In this embodiment of the application, the capture component 100 is composed of multiple annular electrodes arranged axially, such as... Figure 1As shown, electrodes 1 to n are arranged axially to form a trapping assembly 100. When arranged axially, the annular electrodes are coaxial and evenly spaced. This structure provides ions with space for axial extension, and the combination of multiple annular electrodes allows for precise control and manipulation of ions at different axial positions. The trapping assembly can achieve radial confinement under the action of a radio frequency voltage source. By applying a specific radio frequency voltage to the annular electrodes, an alternating electric field is generated around the electrodes. This alternating electric field exerts a radial constraint force on the ions, confining them to the vicinity of the central region of the trapping assembly and preventing ions from diffusing and escaping in the radial direction. For example, when adjacent annular electrodes are subjected to radio frequency voltages with opposite phases, a stable radial potential well is formed at the center of the array, trapping the ions within it.

[0042] In this embodiment, one sensing component can correspond to one annular electrode. Each sensing component can be disposed on the inner wall of the corresponding annular electrode.

[0043] In this embodiment, the radio frequency (RF) voltage source may include a signal generator, a power amplifier, and a filtering circuit. The signal generator generates an RF signal of a specific frequency and phase. The power amplifier amplifies the signal power to a sufficient level to meet the requirements for applying an RF voltage to the ring electrodes. The filtering circuit filters out noise and spurious signals to ensure the purity of the RF voltage. The signal generator generates a sinusoidal RF signal, which is amplified by the power amplifier, filtered by the filtering circuit, and then connected to each ring electrode to provide an RF voltage with opposite phase to the electrode. By adjusting the frequency and amplitude of the signal generator, the depth and width of the radial potential well can be controlled, thereby adapting to the confinement requirements of ions of different types and energies.

[0044] In some embodiments, the capture component further includes: a DC voltage source connected to each ring electrode and used to apply a DC voltage to each ring electrode to form an electric field gradient or potential well that increases along the axial direction.

[0045] In this embodiment, the DC voltage source can apply an axially increasing DC voltage to each ring electrode. Since there is a voltage difference between adjacent electrodes, an axially increasing electric field gradient will be formed in the axial direction. Under the combined action of the electric field gradient and the airflow, the ions can achieve stable equilibrium and be distributed at different positions according to their mobility.

[0046] In this embodiment, the potential well is formed by precisely adjusting the DC voltage of each annular electrode. A potential well can be formed inside the capture component, which acts like an "energy trap" to capture ions. For example, by setting a lower voltage in the middle part of the array and a higher voltage on both sides, the ions will be confined to the middle region with the lower voltage.

[0047] In this embodiment, the DC voltage source may include multiple independent DC power supply modules, each providing a stable DC voltage to one or more ring electrodes. Each DC power supply module includes a power conversion circuit, a voltage regulator circuit, and a voltage adjustment circuit, capable of converting input AC or DC power into the required stable DC voltage, and allowing precise adjustment of the output voltage via the adjustment circuit. Each DC power supply module is connected to its corresponding ring electrode. Based on the analytical requirements, by adjusting the output voltage of each module, an axially increasing or decreasing DC voltage is applied to each ring electrode to form an axially increasing electric field gradient. Simultaneously, by precisely adjusting the DC voltage of each electrode, the required potential well can be formed within the capture assembly, enabling the capture and storage of ions.

[0048] The analytical apparatus provided in this application uses an RF voltage source that applies RF voltages with opposite phases to adjacent ring electrodes. This creates a stable radial potential well at the center of the trapping component, precisely confining ions to the central region and effectively preventing ion diffusion and escape in the radial direction, thus improving the stability and reliability of ions during analysis. A DC voltage source applies an axial DC voltage to each ring electrode, creating an axially increasing electric field gradient. By adjusting the magnitude and distribution of the DC voltage, the migration speed and position of ions in the axial direction can be flexibly controlled, achieving precise ion manipulation. This apparatus combines radial confinement, axially increasing electric field gradient, and potential well control, supporting multiple analytical modes. Because the parameters of the RF and DC voltage sources can be flexibly adjusted, this apparatus can adapt to the analytical needs of ions with different types and properties.

[0049] In some embodiments, the analysis apparatus further includes: A pressure sensor is used to detect the airflow pressure within the capture assembly to control the vacuum and intake system; a flow controller is used to control the airflow input from the vacuum and intake system to the capture assembly.

[0050] In this embodiment, a pressure sensor is installed inside the capture assembly to directly sense the airflow pressure within the assembly. When the airflow pressure changes, the sensitive element inside the sensor (such as a silicon diaphragm, piezoelectric material, etc.) undergoes a corresponding physical change, converting it into an electrical signal. This electrical signal is amplified, processed, and then transmitted to the control system. The control system determines whether to adjust the operating state of the vacuum and intake systems based on a preset pressure threshold. For example, when the pressure sensor detects that the pressure inside the capture assembly is too high, the control system increases the pumping speed of the vacuum pump or decreases the opening of the intake valve; when the pressure is too low, it decreases the pumping speed of the vacuum pump or increases the opening of the intake valve.

[0051] In this embodiment, the flow controller is installed on the intake pipe of the vacuum and intake system. A flow sensor measures the airflow entering the capture component in real time and transmits the measurement signal to the flow controller. The flow controller compares the actual measured value with a preset flow rate value. If the actual flow rate is greater than the preset flow rate, the controller outputs a signal to decrease the opening of the control valve; if the actual flow rate is less than the preset flow rate, it outputs a signal to increase the opening of the control valve. In this way, the flow controller can precisely control the airflow input to the capture component, meeting the needs of different analytical experiments.

[0052] The analytical apparatus provided in this application embodiment features a pressure sensor capable of real-time detection of the gas flow pressure within the capture component and feeding this pressure information back to the control system. The control system adjusts the operating status of the vacuum and intake systems promptly based on pressure changes, ensuring that the pressure within the capture component remains within a suitable range. A stable pressure environment reduces gas flow interference during ion movement, improving the stability and predictability of ion movement, thereby providing more accurate data for subsequent ion analysis and detection. A flow controller precisely controls the gas flow rate input to the capture component. During ion analysis, a suitable gas flow rate is crucial for ion generation, transport, and detection. Precise control by the flow controller avoids problems such as ion concentration fluctuations and signal interference caused by excessively high or low gas flow rates, improving the accuracy and repeatability of the analytical results.

[0053] In some embodiments, the sensing component includes any one of a ring-shaped induction coil, a sector-shaped induction electrode, and an arc-shaped electrode.

[0054] In this embodiment, the sensing component is not limited to a ring design; it can be fan-shaped or segmented electrode type. In some embodiments, when the sensing component is an arc-shaped electrode, the arc-shaped electrode includes: a 90° arc-shaped electrode, and the number of the 90° arc-shaped electrodes is four. The four 90° arc-shaped electrodes are disposed on the inner wall of the corresponding ring electrode and distributed in four quadrants.

[0055] In this embodiment, the 90° arc-shaped electrode is circular in shape, and its arc length, radius, and other dimensions are designed according to the specifications of the ring electrode. Typically, the radius of the arc-shaped electrode is slightly smaller than the inner radius of the ring electrode to ensure a tight and suitable installation on the inner wall of the ring electrode, while ensuring sufficient contact area with the ion movement region to effectively sense ion-related information. Four 90° arc-shaped electrodes are respectively disposed on the inner wall of the corresponding ring electrode and evenly distributed in the four quadrants. Specifically, a Cartesian coordinate system is established with the center of the ring electrode as the origin, dividing the inner wall of the ring electrode into four 90° sector regions (i.e., four quadrants), with one 90° arc-shaped electrode installed in each quadrant. This distribution allows the arc-shaped electrodes to cover the inner wall of the ring electrode omnidirectionally, sensing the movement of ions from different directions and angles. Each 90° arc-shaped electrode is connected to a signal acquisition system via a wire. The signal acquisition system can monitor the current changes in the arc-shaped electrodes in real time and convert these analog signals into digital signals. The converted digital signal is transmitted to the data processing unit, which amplifies, filters, and denoises the signal to eliminate interference and noise, improving signal quality and reliability. Since the four 90° arc-shaped electrodes are distributed in different quadrants, the ion motion information they sense also differs. By comprehensively analyzing the signals collected by the four arc-shaped electrodes, a more complete understanding of the ion motion state within the ring electrode can be obtained. For example, by comparing the intensity and time differences of the arc-shaped electrode signals in different quadrants, information such as the ion's direction of motion, velocity, and distribution can be inferred.

[0056] The analytical device provided in this application has four 90° arc-shaped electrodes evenly distributed in four quadrants, enabling it to sense ion movement from different directions and angles. Compared to sensing methods using a single electrode or a small number of electrodes, this omnidirectional sensing method can capture ion movement information more comprehensively, reducing sensing blind spots caused by the uncertainty of ion movement direction, thereby improving the sensitivity of ion sensing. The signals sensed by the arc-shaped electrodes in different quadrants contain ion movement information at different positions and directions. Through comprehensive analysis of this multi-dimensional information, parameters such as ion position, velocity, and trajectory can be determined more accurately, improving the accuracy of ion analysis.

[0057] In some embodiments, the capture assembly can be divided into multiple functional segments along the axial direction. For example, the front electrode in the capture assembly is specifically optimized for ion focusing and separation in migration spectroscopy mode, while the rear electrode in the capture assembly is specifically optimized for high-precision frequency detection in mass spectrometry mode. The geometry, RF frequency, or DC gradient of each electrode segment can be optimized independently to achieve optimal performance in its respective mode.

[0058] Based on the analysis devices provided in the foregoing embodiments, this application provides a parameter determination method that can be applied to electronic devices, including: mobile phones, tablets, wearable devices, augmented reality (AR) / virtual reality (VR) devices, laptops, ultra-mobile personal computers (UMPCs), netbooks, personal digital assistants (PDAs), etc. The electronic device can serve as the controller for the analysis device. The analysis device and the electronic device can form a parameter analysis system, and the electronic device can also serve as the control system for the parameter analysis system.

[0059] Figure 2 A schematic diagram illustrating the implementation process of a parameter determination method provided for the purposes of this application is shown below. Figure 2 As shown, the parameter determination methods include: Step S201: Control the analysis device described above based on the control method corresponding to the target analysis mode. The target analysis mode includes: migration spectrum analysis mode or mass spectrometry analysis mode.

[0060] In this embodiment, the migration spectrum analysis mode separates and analyzes ions based on their migration characteristics in an electric field and gas flow, which is suitable for rapidly distinguishing ions with different mobilities. The mass spectrometry analysis mode determines the mass-to-charge ratio (m / z) by measuring the cyclotron frequency of ions in a magnetic field or the motion characteristics in a mass selector, which is suitable for accurate molecular weight determination and structural analysis.

[0061] In this application embodiment, different target analysis modes correspond to different control methods.

[0062] Step S202: Obtain the current sensing signal detected by the sensing component of the analysis device.

[0063] In this embodiment, the current sensing signal is a periodic current signal generated by the sensing component (such as an arc electrode) during the ion's gyratory motion, and its frequency or peak position reflects the ion characteristics.

[0064] In this embodiment of the application, the detected current sensing signal can be amplified, filtered, and converted from analog to digital.

[0065] Step S203: Determine the parameters corresponding to the target analysis mode based on the current sensing signal. When the target analysis mode is a migration spectrum analysis mode, the parameter corresponding to the migration spectrum analysis mode is the ion mobility. When the target analysis mode is a mass spectrometry analysis mode, the parameter corresponding to the mass spectrometry analysis mode is the ion mass-to-charge ratio.

[0066] In this embodiment, the mass-to-charge ratio (m / z) is the ratio of ion mass to charge number, calculated using the cyclotron frequency f = qB / 2πm.

[0067] In this embodiment, mobility can be calculated based on a calibration curve. The calibration curve is established by experimentally establishing a linear relationship between mobility and electrode position. The current sensing signal can be FFT transformed, and the cyclotron frequency can be calculated from the peak frequency to obtain the mass-to-charge ratio.

[0068] The method provided in this application embodiment achieves control through hardware reuse (capture component, magnetic field, sensing component) and software control, and through the control method corresponding to the target analysis mode, and can realize switching between ion mobility spectrometry mode and mass spectrometry mode.

[0069] In some embodiments, Figure 3 This application provides a schematic diagram of the implementation process of step S201, as shown in the embodiment. Figure 3 As shown, step S201 can be achieved through the following steps: Step S2011: When the target analysis mode is the migration spectrum analysis mode, gas is introduced into the capture component to achieve a first preset vacuum level and form an axial airflow.

[0070] In this embodiment, the vacuum and air intake system can be controlled to fill the trapping component with buffer gas (such as nitrogen or helium). The gas is filled from the inlet end of the trapping component and pumped out from the outlet end by a vacuum pump to form a stable axial airflow.

[0071] Step S2012: Control the capturing component to generate a reverse electric field gradient opposite to the axial airflow and provide radial confinement to the ions so that ions with different mobilities are separated and remain in the axial direction, and control the magnetic field generating component to generate a magnetic field along the axial direction.

[0072] In this embodiment, the trapping assembly consists of multiple concentric ring electrodes, each independently subjected to a DC voltage. The voltage gradient is designed with a high voltage at the inlet and a low voltage at the outlet, creating an electric field opposite to the axial airflow direction. This allows the application of radio frequency voltage between adjacent ring electrodes, generating a pseudo-potential well and restricting radial ion diffusion. Simultaneously, an external magnetic field component (such as an electromagnet or permanent magnet) generates a uniform magnetic field along the axial direction of the trapping assembly. When ions enter the trapping assembly and are trapped by the potential well, they undergo synchronous gyratory motion around the magnetic field axis under the influence of the axial magnetic field.

[0073] In this embodiment of the application, the above operations can cause ions with different mobilities to remain at different positions under electric field-gas flow equilibrium. Figure 4 This application provides a schematic diagram of an ion dwell position according to an embodiment of the present application, such as... Figure 4As shown, ions with different mobilities remain at different positions under electric field-airflow equilibrium.

[0074] Step S2013: Control the capture component to operate in a preset working mode, wherein the capture component operating in the preset working mode includes: when the i-th ring electrode is closed, the ions at the position corresponding to the i-th ring electrode undergo cycloidal motion, the sensing component of the analysis device acquires the current sensing signal of the ions at the position corresponding to the i-th ring electrode, and when the current sensing signal of the i-th ring electrode is acquired, control the i-th ring electrode to operate and control the (i+1)-th ring electrode to close, the sensing component of the analysis device acquires the current sensing signal of the ions at the position corresponding to the (i+1)-th ring electrode, where i is a positive integer greater than or equal to 1.

[0075] In this embodiment, the radio frequency voltage of the i-th electrode can be disconnected via a relay matrix, causing the ions at that position to lose their radial binding. Under the influence of an axial magnetic field, the ions undergo gyratory motion, generating a periodic current signal. Figure 5 This is a schematic diagram of ion cyclotron motion provided in an embodiment of this application, as shown below. Figure 5 As shown in the figure, the circles represent the cyclonic motion trajectory of ions. The sensing component (such as an arc electrode) detects the current signal. After detecting the peak value of the signal at the i-th electrode, it immediately restores its radio frequency voltage and simultaneously shuts off the (i+1)-th electrode to enter the next round of detection.

[0076] The method provided in this application embodiment enables high resolution, high sensitivity, and rapid detection in migration spectrum analysis.

[0077] In some embodiments, step S203 can be implemented by the following steps: Step S2031: Determine the electrode positions corresponding to each peak value based on the current sensing signal.

[0078] In this embodiment, the characteristic parameters of the current-sensing signal include: signal frequency (reflecting ion cyclotron frequency), amplitude (reflecting ion abundance), and the position of the maximum amplitude (related to the electrode position). Here, the position of the maximum amplitude corresponds to the peak value, and the electrode position is the axial coordinate of each annular electrode in the capture assembly. The electrode position, along with the electric field strength and gas flow velocity, jointly determine the ion retention conditions.

[0079] In this embodiment, the electrode position corresponding to the peak value can be determined by methods such as threshold comparison, second derivative method, and timing alignment.

[0080] Step S2032: Determine the ion mobility based on the electrode position and a pre-established calibration curve, wherein the calibration curve includes the correspondence between the mobility of each ion and the electrode position under the reverse electric field gradient.

[0081] In this embodiment, the reverse electric field gradient is an electric field distribution with the electric field direction opposite to the axial airflow direction, used to balance ion migration force and airflow drag force. The calibration curve is the mapping relationship between ion mobility (K) and electrode position established experimentally. A standard sample injection analysis device with known mobility can be used to record the electrode positions where standard sample ions reside, and the calibration curve can be obtained through linear regression.

[0082] In this embodiment of the application, after obtaining the electrode position, the ion mobility can be calculated using the calibration curve.

[0083] The method provided in this application embodiment achieves high-precision, rapid, and interference-resistant detection of ion mobility by mapping the spatial positioning of current sensing signals with calibration curves.

[0084] The following is a specific example of mobility analysis using a mobility spectrum analysis model: The vacuum and intake system is filled with gas, maintained at a certain vacuum pressure, and forms a stable axial airflow (vg).

[0085] The capture component applies an RF voltage and an increasing DC voltage, creating a reverse electric field gradient (Ex). After ion implantation, ions with different mobilities (K) reach a force equilibrium under the combined influence of the reverse electric field force and the gas flow drag force, stabilizing in electric field regions of varying intensities, i.e., focusing at different positions along the axial direction. Ions with high mobility focus in regions with higher DC voltage (i.e., larger Ex) (near the inlet), while ions with low mobility (typically larger) focus in regions with lower DC voltage (near the outlet). Thus, ions are separated along the axial direction according to their mobility. Simultaneously, the RF voltage provides radial constraint, ensuring that ion clusters remain stable near their respective electrodes.

[0086] Starting from the inlet, the RF voltage of specific electrodes i is sequentially and briefly turned off. The ion packs at those locations lose their radial constraint and begin to gyrate in the magnetic field. The induction coil on electrode i detects the induced current signal generated by this gyratory motion. The electrode position i where the signal appears is recorded. The RF voltage of electrode i is restored, and the next electrode is scanned. Finally, by combining the electrode positions i where all signal peaks appear with a pre-defined calibration curve, the mobility K of all ion packs is calculated.

[0087] In some embodiments, the method further includes: Step S204: If interfering ions are determined to exist based on ion mobility, the voltage information of the ring electrode at the electrode position corresponding to the interfering ion is adjusted to remove the interfering ions.

[0088] In this embodiment, the interfering ions are other ions with similar mobilities to the target ion during analysis. Spatial separation can be achieved by changing the voltage of the electrode corresponding to the interfering ion, causing its mobility to deviate from that of the target ion.

[0089] The method provided in this application embodiment achieves efficient, real-time, and low-cost removal of interfering ions by dynamically adjusting the voltage of the ring electrode, significantly improving the anti-interference capability and analytical accuracy of ion mobility spectrometry.

[0090] In some embodiments, step S201 can be implemented by the following steps: Step S2014: When the target analysis mode is mass spectrometry analysis mode, the environment inside the capture component is evacuated to a second preset vacuum level.

[0091] In this embodiment, when the target analysis mode is determined to be mass spectrometry analysis mode, the vacuum and gas intake system is controlled to evacuate the environment inside the capture component to the second preset vacuum level according to a preset second vacuum level. This can be achieved by starting the vacuum pump and opening the corresponding valves to connect the vacuum pump to the capture component and begin extracting the gas. During the evacuation process, the control system continuously monitors the vacuum level. When the vacuum level reaches the second preset vacuum level, the vacuum pump and corresponding valves are shut off, stopping the evacuation and maintaining the environment inside the capture component at the required second preset vacuum level. By evacuating the internal environment of the capture component to the vacuum level required for mass spectrometry analysis (the second preset vacuum level), collisions between ions and residual gas molecules are reduced, ion energy loss and scattering are decreased, and the controllable trajectory of ions in the electric / magnetic field is ensured.

[0092] Step S2015: Control the trapping component to form a potential well and provide radial confinement to the ions, and control the magnetic field generating component to generate a magnetic field along the axial direction, wherein, in the case of forming a potential well, the ions are trapped within the potential well.

[0093] In this embodiment, a three-dimensional potential well is formed by the voltage distribution of the trapping component, trapping ions and restricting their radial motion, providing initial constraints for subsequent cyclotron motion. A uniform magnetic field (B) is perpendicular to the ion velocity, causing the ions to cyclotron in the radial plane (the Lorentz force provides the centripetal force).

[0094] Step S2016: Reduce the voltage of each ring electrode in the capture assembly to reduce the radial confinement of ions by the capture assembly. When the radial confinement of ions by the capture assembly is reduced, the ions undergo cyclotron motion. The sensing component of the analysis device synchronously acquires the current sensing signal of ions at the corresponding positions of each ring electrode.

[0095] In this embodiment, by gradually reducing the voltage of the trapping component, the radial electric field strength is decreased, causing the ions to gradually break free from the radial binding under the action of the Lorentz force and enter a stable cyclotron motion trajectory. As the ions cyclotron in the magnetic field, they periodically pass through specific positions of the trapping component, thus enabling the sensing component to detect them.

[0096] The method provided in this application embodiment achieves precise control of ions from capture to cyclotron motion through coordinated control of electric and magnetic fields. Combined with high-speed signal acquisition and processing, it provides a high-resolution and high-sensitivity solution for mass spectrometry analysis.

[0097] The following is a specific example of electron mass-to-charge ratio analysis in a mass spectrometry analysis mode: The vacuum and intake system is evacuated to a high vacuum, and the airflow is stopped.

[0098] Adjusting the DC voltage of the electrodes creates a potential trap in the trapping assembly, capturing all ions.

[0099] At the same time, the RF voltage amplitude of all electrodes is reduced, causing all ions to begin gyratory motion simultaneously in the magnetic field.

[0100] The induced signals from all electrodes were collected synchronously, combined, and then subjected to FFT analysis to obtain the cyclotron frequency spectrum.

[0101] According to the formula f = (qB) / (2πm), the mass-to-charge ratio m / z of each ion can be directly calculated from the frequency f.

[0102] In some embodiments, step S201 can be implemented by the following steps: Step S2017: When the target analysis mode is mass spectrometry analysis mode, the environment inside the capture component is evacuated to a second preset vacuum level.

[0103] Step S2018: Control the capture component to form a potential well.

[0104] In this embodiment, a specific voltage can be applied to each ring electrode in the trapping assembly. For example, by adjusting the voltage difference between adjacent ring electrodes, ions can be confined to a specific region under the influence of an electric field, forming a potential well.

[0105] Step S2019: Control the magnetic field generating component to generate a magnetic field along the axial direction so that the ions rotate synchronously, and the sensing component synchronously collects the current sensing signals of the ions at the corresponding positions of each ring electrode.

[0106] In this embodiment of the application, when ions enter the trapping component and are trapped by the potential trap, under the action of the axial magnetic field, the ions will perform synchronous gyratory motion around the magnetic field axis.

[0107] In this embodiment, when ions synchronously cyclone within the trapping assembly, their motion generates current-sensing signals at corresponding positions of the various ring electrodes. Each current sensor in the sensing assembly collects these current signals in real time and controls the system based on the collected signals.

[0108] In this embodiment of the application, in mass spectrometry mode, a stable axial magnetic field is not always applied. Instead, a pulsed approach is used: first, the magnetic field is turned off to release the radial confinement of ions and allow them to diffuse; then, a strong pulsed magnetic field is applied instantaneously to induce ions to begin synchronous cyclotron, and the resulting free-induction decay signal is detected. This approach may help obtain a time-domain signal with a higher signal-to-noise ratio, facilitating FFT analysis.

[0109] The method provided in this application embodiment can effectively control the analysis device in mass spectrometry analysis mode and complete key operations such as ion capture, cyclotron motion and signal acquisition.

[0110] In some embodiments, step S203 can be implemented by the following steps: Step S2033: Convert the current sensing signal of the ions at the corresponding positions of each ring electrode to the frequency domain to obtain the cyclotron frequency spectrum of the ions.

[0111] In this embodiment, the frequency domain, as opposed to the time domain, is the domain in which signals are decomposed and analyzed according to their frequency components. In the frequency domain, a signal can be represented as a superposition of different frequency components. By converting the signal from the time domain to the frequency domain, the frequency characteristics of the signal can be analyzed more intuitively. The cyclotron frequency spectrum is a spectrum obtained by converting the current-induced signals of ions at corresponding positions of each ring electrode to the frequency domain. In this spectrum, different peaks correspond to the cyclotron frequencies of different ions, reflecting the frequency characteristics of the ions' cyclotron motion in the magnetic field. In this embodiment, the current-induced signals of ions at corresponding positions of each ring electrode are signals that vary with time. By performing a Fourier transform on them, information about different frequency components in the signal can be extracted to form a cyclotron frequency spectrum. In this spectrum, different peaks correspond to the cyclotron frequencies of different ions.

[0112] Step S2034: Calculate the mass-to-charge ratio of each ion based on the cyclotron frequency spectrum.

[0113] In this embodiment, the mass-to-charge ratio of each ion can be calculated based on the cyclotron frequency of each ion, the magnetic induction intensity of the magnetic field, and the charge of the ion.

[0114] In some embodiments, the method further includes: Step S205: After obtaining the mass-to-charge ratio and mobility of ions, the mass-to-charge ratio and mobility of the same ion are correlated, and a two-dimensional spectrum is generated, wherein the two-dimensional spectrum includes the mass-to-charge ratio and mobility of ions.

[0115] In this application embodiment, association can be performed based on the unique identifying features of the ion signals in two modes. In some embodiments, machine learning methods can be used for association.

[0116] The method provided in this application significantly reduces the number of parts and the overall size and weight of the system by sharing the trapping component, the magnetic field generating component, and the sensing component, laying the foundation for developing low-cost, portable integrated analytical instruments. In migration spectrum mode, ions with different mobilities are stably trapped at different equilibrium positions along the axis. During detection, the mobility is directly determined by reading the spatial distribution position of the ions, eliminating the need for the elution step in traditional trapping ion migration spectrometry, avoiding the resolution limitations caused by the elution process, and providing an alternative method for ion migration detection.

[0117] It should be understood that the sequence number of each step in the above embodiments does not imply the order of execution. The execution order of each process should be determined by its function and internal logic, and should not constitute any limitation on the implementation process of the embodiments of this application.

[0118] According to the foregoing embodiments, this application provides a parameter determination device. The various modules and units included in the device can be implemented by a processor in a computer device; of course, they can also be implemented by specific logic circuits. In the implementation process, the processor can be a central processing unit (CPU), a microprocessor unit (MPU), a digital signal processor (DSP), or a field programmable gate array (FPGA), etc.

[0119] This application provides a parameter determination device, which is used to control the analysis device in the above embodiments. Figure 6 This is a schematic diagram of the structure of a parameter determination device provided in an embodiment of this application, as shown below. Figure 6 As shown, the parameter determining device 600 includes: The control module 601 is used to control the analysis device described above based on the control method corresponding to the target analysis mode, wherein the target analysis mode includes: migration spectrum analysis mode or mass spectrometry analysis mode. Acquisition module 602 is used to acquire the current sensing signal detected by the sensing component of the analysis device; The parameter determination module 603 is used to determine the parameters corresponding to the target analysis mode based on the current sensing signal. When the target analysis mode is a migration spectrum analysis mode, the parameter corresponding to the migration spectrum analysis mode is the ion mobility. When the target analysis mode is a mass spectrometry analysis mode, the parameter corresponding to the mass spectrometry analysis mode is the ion mass-to-charge ratio.

[0120] In some embodiments, the control module 601 includes: The first control unit is used to fill the capture component with gas when the target analysis mode is the migration spectrum analysis mode, so as to achieve an environment with a first preset vacuum degree and form an axial airflow. The second control unit is used to control the capturing component to generate a reverse electric field gradient opposite to the axial airflow and to provide radial confinement to the ions so that ions with different mobility rates are separated and remain in the axial direction, and to control the magnetic field generating component to generate a magnetic field along the axial direction. The third control unit is used to control the capture component to operate in a preset working mode, wherein the capture component operates in the preset working mode as follows: when the i-th ring electrode is closed, the ions at the position corresponding to the i-th ring electrode undergo cycloidal motion, the sensing component acquires the current sensing signal of the ions at the position corresponding to the i-th ring electrode, and when the current sensing signal of the i-th ring electrode is acquired, the i-th ring electrode is controlled to operate, and the (i+1)-th ring electrode is controlled to close, and the sensing component acquires the current sensing signal of the ions at the position corresponding to the (i+1)-th ring electrode, where i is a positive integer greater than or equal to 1.

[0121] In some embodiments, the parameter determination module 603 includes: The first determining unit is used to determine the electrode position corresponding to each peak value based on the current sensing signal; The second determining unit is used to determine the ion mobility based on the electrode position and a pre-established calibration curve, wherein the calibration curve includes the correspondence between the mobility of each ion and the electrode position under the reverse electric field gradient.

[0122] In some embodiments, the parameter determining device 600 further includes: An adjustment module is used to adjust the voltage information of the ring electrode at the electrode position corresponding to the interfering ion to remove the interfering ion when the presence of interfering ions is determined based on the ion mobility.

[0123] In some embodiments, the control module 601 includes: The fourth control unit is used to evacuate the environment inside the capture component to a second preset vacuum level when the target analysis mode is mass spectrometry analysis mode. The fifth control unit is used to control the trapping component to form a potential well and provide radial confinement to the ions, and to control the magnetic field generating component to generate a magnetic field along the axial direction, wherein, in the case of forming a potential well, the ions are trapped in the potential well. The sixth control unit is used to reduce the voltage of each annular electrode in the capture assembly to reduce the radial confinement of ions by the capture assembly. When the radial confinement of ions by the capture assembly is reduced, the ions undergo gyratory motion. The sensing assembly synchronously acquires the current sensing signal of ions at the corresponding positions of each annular electrode.

[0124] In some embodiments, the control module 601 includes: The seventh control unit is used to evacuate the environment inside the capture component to a second preset vacuum level when the target analysis mode is mass spectrometry analysis mode. The eighth control unit is used to control the capture component to form a potential well; The ninth control unit is used to control the magnetic field generating component to generate a magnetic field along the axis so that the ions rotate synchronously, and the sensing component synchronously collects the current sensing signals of the ions at the corresponding positions of each ring electrode in the capturing component.

[0125] In some embodiments, the parameter determination module 603 includes: The conversion unit is used to convert the current sensing signal of the ions at the corresponding positions of each ring electrode into the frequency domain to obtain the cyclotron frequency spectrum of the ions. The calculation unit is used to calculate the mass-to-charge ratio of each ion based on the cyclotron frequency spectrum.

[0126] In some embodiments, the parameter determining device 600 includes: The correlation module is used to correlate the mass-to-charge ratio and mobility of the same ion when the mass-to-charge ratio and mobility of the ion are obtained, and to generate a two-dimensional spectrum, wherein the two-dimensional spectrum includes the mass-to-charge ratio and mobility of the ion.

[0127] It should be noted that the information interaction and execution process between the above-mentioned devices / units are based on the same concept as the method embodiments of this application. For details on their specific functions and technical effects, please refer to the method embodiments section, and they will not be repeated here.

[0128] In addition, the parameter determination device described above can be a software unit, a hardware unit, or a combination of software and hardware. It can also be integrated into electronic devices as an independent component, or exist as an independent terminal device.

[0129] Those skilled in the art will clearly understand that, for the sake of convenience and brevity, the above-described division of functional units and modules is merely an example. In practical applications, the above functions can be assigned to different functional units and modules as needed, that is, the internal structure of the device can be divided into different functional units or modules to complete all or part of the functions described above. The functional units and modules in the embodiments can be integrated into one processing unit, or each unit can exist physically separately, or two or more units can be integrated into one unit. The integrated unit can be implemented in hardware or as a software functional unit. Furthermore, the specific names of the functional units and modules are only for easy differentiation and are not intended to limit the scope of protection of this application. The specific working process of the units and modules in the above system can be referred to the corresponding process in the foregoing method embodiments, and will not be repeated here.

[0130] Figure 7 This is a schematic diagram of the structure of an electronic device provided in an embodiment of this application. Figure 7 As shown, the electronic device of this embodiment may include: at least one processor 30 ( Figure 7 Only one processor 30, memory 31, and computer program 32 stored in memory 31 and executable on at least one processor 30 are shown. When the processor 30 executes the computer program 32, it implements the steps in any of the above method embodiments, or the processor 30 executes the computer program 32 to implement the functions of each module / unit in the above device or system embodiments.

[0131] For example, computer program 32 may be divided into one or more modules / units, one or more of which are stored in memory 31 and executed by processor 30 to complete this application. One or more modules / units may be a series of computer program 32 instruction segments capable of performing a specific function, which describe the execution process of computer program 32 in an electronic device.

[0132] This application also provides a computer-readable storage medium storing a computer program 32, which, when executed by a processor 30, implements the steps described in the above-described method embodiments.

[0133] This application provides a computer program product that, when run on an electronic device, enables the electronic device to perform the steps described in the various method embodiments above.

[0134] If the integrated unit is implemented as a software functional unit and sold or used as an independent product, it can be stored in a computer-readable storage medium. Based on this understanding, all or part of the processes in the methods of the above embodiments of this application can be implemented by a computer program 32 instructing related hardware. The computer program 32 can be stored in a computer-readable storage medium, and when executed by the processor 30, it can implement the steps of the various method embodiments described above. The computer program 32 includes computer program code, which can be in the form of source code, object code, executable files, or certain intermediate forms. The computer-readable medium can include at least: any entity or device capable of carrying computer program code to a terminal, a recording medium, a computer memory, a read-only memory (ROM), a random access memory (RAM), an electrical carrier signal, a telecommunication signal, and a software distribution medium. Examples include USB flash drives, portable hard drives, magnetic disks, or optical disks.

[0135] Based on the foregoing embodiments, this application provides a parameter analysis system, including the analysis device described in the above embodiments, wherein the parameter analysis system can be used to obtain ion mobility or mass-to-charge ratio.

[0136] In the above embodiments, the descriptions of each embodiment have different focuses. For parts that are not described in detail or recorded in a certain embodiment, please refer to the relevant descriptions of other embodiments.

[0137] Those skilled in the art will recognize that the units and algorithm steps of the various examples described in conjunction with the embodiments disclosed herein can be implemented in electronic hardware, or a combination of computer software and electronic hardware. Whether these functions are implemented in hardware or software depends on the specific application and design constraints of the technical solution. Those skilled in the art can use different methods to implement the described functions for each specific application, but such implementation should not be considered beyond the scope of this application.

[0138] In the embodiments provided in this application, it should be understood that the disclosed apparatus / network devices and methods can be implemented in other ways. For example, the apparatus / network device embodiments described above are merely illustrative. For instance, the division of modules or units is only a logical functional division, and in actual implementation, there may be other division methods. For example, multiple units or components may be combined or integrated into another system, or some features may be ignored or not executed. Furthermore, the coupling or direct coupling or communication connection shown or discussed may be through some interfaces; the indirect coupling or communication connection between devices or units may be electrical, mechanical, or other forms.

[0139] The units described as separate components may or may not be physically separate. The components shown as units may or may not be physical units; that is, they may be located in one place or distributed across multiple network units. Some or all of the units can be selected to achieve the purpose of this embodiment according to actual needs.

[0140] The above-described embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this application, and should all be included within the protection scope of this application.

Claims

1. An analytical device, characterized by The analysis device comprises: a capturing assembly for capturing different ions at different positions along an axial direction; a magnetic field generating assembly for generating a magnetic field along the axial direction to make the ions perform cyclotron motion; a sensing assembly arranged inside the capturing assembly for detecting a current sensing signal generated by the cyclotron motion of the ions in the capturing assembly.

2. The analysis device of claim 1, wherein, The capturing assembly comprises a plurality of ring electrodes arranged along the axial direction; a radio frequency voltage source connected to each ring electrode and configured to apply radio frequency voltages with opposite phases to the ring electrodes to make the capturing assembly provide radial confinement to the ions in the capturing assembly.

3. The analysis device of claim 2, wherein, The capturing assembly further comprises: a direct current voltage source connected to each ring electrode and configured to apply a direct current voltage to each ring electrode to form an electric field gradient or potential well increasing along the axial direction.

4. The analysis device of claim 1, wherein, The analysis device further comprises: a data processing assembly configured to obtain the position and cyclotron frequency of the ions based on the current sensing signal obtained by the sensing assembly, and obtain the mobility and mass-to-charge ratio of the ions based on the position and the cyclotron frequency.

5. The analysis device of claim 1, wherein, The analysis device further comprises: a vacuum and gas inlet system configured to provide a preset vacuum degree environment and / or input gas flow into the capturing assembly.

6. The analysis device of claim 5, wherein, The analysis device further comprises: a pressure sensor configured to detect the gas flow pressure in the capturing assembly to control the vacuum and gas inlet system; a flow controller configured to control the vacuum and gas inlet system to input the gas flow into the capturing assembly.

7. The analysis device of claim 1, wherein, The sensing assembly comprises any one of a ring-shaped sensing coil, a sector-shaped sensing electrode, and an arc-shaped electrode.

8. The analysis device of claim 7, wherein, In the case where the sensing assembly is an arc-shaped electrode, the arc-shaped electrode comprises four 90° arc-shaped electrodes arranged on the inner wall of the corresponding ring electrode and distributed in four quadrants.

9. A parameter determination apparatus characterized by comprising: The control module is configured to control the analysis device according to the control mode corresponding to the target analysis mode, wherein the target analysis mode comprises a mobility spectrum analysis mode or a mass spectrum analysis mode. The acquisition module is configured to acquire the current sensing signal detected by the sensing assembly of the analysis device. The parameter determination module is configured to determine the parameter corresponding to the target analysis mode based on the current sensing signal, wherein the parameter corresponding to the mobility spectrum analysis mode is the mobility of the ions when the target analysis mode is the mobility spectrum analysis mode, and the parameter corresponding to the mass spectrum analysis mode is the mass-to-charge ratio of the ions. The parameter analysis system comprises the analysis device according to any one of claims 1 to 8, and is configured to obtain the mobility or mass-to-charge ratio of the ions.

10. A parameter analysis system characterized by comprising: ​

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