Closed configuration device and method for chemotherapeutic drugs

Abstract

The invention relates to the technical field of medical instruments, and discloses a chemotherapeutic drug closed configuration device and a configuration method.The chemotherapeutic drug closed configuration device comprises a closed box, a configuration table is fixedly arranged in the closed box, falling openings are formed in the two sides of the configuration table respectively, and a breaking assembly used for breaking an AnBei bottle is arranged on the surface of the configuration table; the breaking assembly comprises an operation table in sliding connection with the configuration table, and a plurality of first containing grooves are formed in the surface of the operation table. A closed operation environment is constructed through the closed box, and harmful gas generated in the preparation process can be purified in real time in cooperation with gas purification equipment with activated carbon adsorption and photocatalytic purification functions; crease cutting, bottleneck breaking and liquid medicine transfer of the ampoule bottle are all automatically completed through a mechanical structure, direct manual contact is not needed, damage to the skin, nerves and blood systems of medical workers caused by biotoxicity of chemotherapy drugs is avoided or reduced, and the problem of contact risks caused by manual ampoule bottle breaking in the prior art is solved.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a closed-loop preparation device and method for chemotherapy drugs. Background Technology

[0002] Chemotherapy is short for chemical drug therapy. Its core principle is to kill cancer cells with chemical drugs, thereby achieving the goal of cancer treatment. It is one of the most effective means of treating cancer at present, and is known as one of the three major treatment methods for cancer, along with surgery and radiotherapy.

[0003] Surgery and radiotherapy are local treatments, effective only against tumor tissue at the treatment site. They are often ineffective against potential metastatic lesions or cancers that have already metastasized clinically. Chemotherapy, on the other hand, is a systemic treatment. Regardless of the route of administration, chemotherapy drugs circulate throughout most organs and tissues of the body via the bloodstream, inhibiting or killing cancer cells across the entire body.

[0004] In clinical applications, chemotherapy drugs typically need to be prepared on-site before administration. However, chemotherapy drugs have strong biotoxicity. If medical personnel accidentally come into contact with these drugs during drug preparation, transportation, or administration, they are highly susceptible to a range of health hazards, including skin damage, hair damage, nervous system damage, and hematological damage. Therefore, how to reduce the health threats of chemotherapy drugs to medical personnel while ensuring their therapeutic efficacy has become an urgent technical problem to be solved in this field.

[0005] A search revealed a Chinese patent (publication number CN118988121B) disclosing a dispensing device for chemotherapy drugs, relating to the field of medical device technology. The device includes a support plate and a drug solution mounting plate installed within a sealed frame. A feeding pipe is fixedly connected to one side of the support plate, and the drug solution mounting plate is slidably connected to the feeding pipe on one side. A sealing cover is rotatably connected to one side of the feeding pipe. A drive motor is fixedly connected to one side of the sealed frame, and a turntable is fixedly connected to the power output end of the drive motor. A drug solution clamping assembly and multiple arc-shaped plates are fixedly connected to one end of the turntable. By using pneumatic springs one and two to press and eject the rotating arc-shaped plates, ampoules are automatically moved from the drug solution mounting plate to the turntable for dispensing, followed by the ejection of the empty ampoules. Simultaneously, the sealed frame, in conjunction with the feeding pipe, allows medical personnel to complete the dispensing process without contact with the drugs, significantly improving the safety of chemotherapy drug dispensing and preventing drug leakage that could harm the health of medical personnel.

[0006] The aforementioned application lacks a method for breaking glass-shaped ampoules, requiring manual breaking. Manual breaking makes it difficult to collect debris and increases the risk of contact with chemotherapy drugs. Summary of the Invention

[0007] In view of the deficiencies of the prior art, the present invention provides a closed configuration device and a configuration method for chemotherapy drugs to solve the problems in the prior art.

[0008] To achieve the above objectives, the present invention is realized through the following technical solutions: A closed configuration device for chemotherapy drugs includes a closed box. Inside the closed box, a configuration table is fixedly installed. On both sides of the configuration table, dropping ports are respectively opened. On the surface of the configuration table, a breaking component for breaking ampoules is provided. The breaking component includes an operating table slidably connected to the configuration table. On the surface of the operating table, a number of placement grooves one are opened. On the side wall of the operating table, a cross slide table one is fixedly installed. On the slider of the cross slide table one, a creasing member is installed. The creasing member includes a motor. The motor is fixedly installed at the slider of the cross slide table one, and the driving end of the motor is fixedly connected to a cylinder body. Inside the cylinder body, a grinding wheel piece is fixedly installed. On the surface of the creasing member, a breaking member is installed.

[0009] Preferably, a notch is opened on the lower side wall of the cylinder body. The breaking member includes an arc-shaped member located in the notch. Inside the inner wall of the arc-shaped member, a U-shaped breaking frame is fixedly installed. On both sides of the arc-shaped member, rotating plates are respectively fixedly installed. The rotating plates are rotationally connected to the cylinder body through torsion spring shafts. On the surface of the cylinder body, a pressing member for pressing down the rotating plate is installed.

[0010] Preferably, the pressing member includes a sliding frame. The sliding frame is arranged outside the vertical slide of the cross slide table one and is slidably connected to the operating table. On the surface of the sliding frame, a notch corresponding to the rotating plate is opened. Below the notch, a baffle is rotationally connected through a torsion spring shaft.

[0011] Preferably, an opening is opened on the surface of the configuration table, and a placement component for placing vials is installed on the surface of the configuration table. Inside the opening, an electric bidirectional slide table is fixedly installed. The placement component includes a placement table slidably connected to the configuration table. On the surface of the placement table, a number of placement grooves two are opened. The two sliders of the electric bidirectional slide table are respectively fixedly connected to the placement table and the operating table. On the opposite sides of the placement table and the operating table, a fixing component for fixing the mixing bottle is provided. The fixing component includes two L-shaped fixing frames. On the surface of the configuration table, two groups of chutes are opened for respectively slidably connecting the two fixing frames. On the opposite sides of the two fixing frames, semi-circular clamping grooves are opened.

[0012] Preferably, a middle-shaped installation cavity is opened inside the lower end of the fixing frame. Inside the installation cavity, a T-shaped clamping block two made of ferromagnetic material is slidably arranged. On the surface of the configuration table, a limiting groove is opened on the movement track of the clamping block two. On both sides of the slider of the electric bidirectional slide table, magnetic attraction plates are respectively fixedly installed.

[0013] Preferably, the fixing frame includes two lower sliding parts and an upper locking part, and a telescopic rod is fixed between the lower sliding parts and the upper locking part. The side walls of the placement platform and the operating platform are respectively fixed with trapezoidal hybrid blocks.

[0014] Preferably, a plurality of receiving slots are provided on the outer side of the placement slot one, and a pressing block is slidably arranged inside the receiving slot. A pressing ring is fixed on the outer side wall of the cylinder, and an annular inclined groove is opened at the bottom inner side of the pressing ring.

[0015] Preferably, a cross slide is fixedly provided on the inner top wall of the sealed box, an electric push cylinder is fixedly provided on the slider of the cross slide, an L-shaped mounting bracket is fixedly provided on the drive end of the electric push cylinder, and a hybrid assembly for fixing and pushing / pushing the syringe is installed inside the mounting bracket.

[0016] Preferably, the hybrid assembly includes an L-shaped rotating frame and an electric slide. One end of the rotating frame is rotatably connected to the mounting frame, and the other end of the rotating frame is detachably connected to the mounting frame. The rotating frame and the mounting frame are respectively provided with semi-circular placement slots. A locking block is fixedly provided on the lower side wall of the rotating frame. The electric slide is vertically fixed on the side wall of the mounting frame, and the slider of the electric slide is fixedly provided with a pull claw.

[0017] A method for the closed-system preparation of a chemotherapy drug, the method comprising: S1, Preparation Stage Open the sealed box of the chemotherapy drug sealing device, start the gas purification equipment with activated carbon adsorption layer and photocatalytic purification function inside the box, and continuously purify the gas inside the box.

[0018] Place the vials containing chemotherapy solution into slot one of the operating table in sequence, and place the vials containing powder into slot two of the operating table in sequence.

[0019] Control the operation of the electric bidirectional slide table to move the placement table and the operating table away from each other, causing the two fixed frames to slide open and place the mixing bottle on the U-shaped placement frame in the center of the configuration table, with the neck of the mixing bottle corresponding to the semi-circular slots of the two fixed frames.

[0020] The reverse-running electric bidirectional slide reduces the distance between the placement platform and the operating platform, pushing the two fixed frames closer together until they close, clamping the neck of the mixing bottle through the slot; at this time, the second locking block in the mounting cavity at the lower end of the fixed frame slides down and inserts into the limiting slot of the configuration platform under the action of the elastic element, completing the fixing and locking of the mixing bottle.

[0021] Finally, open the rotating frame of the mixing component, place the syringe in the placement slot three, close the rotating frame, so that the syringe barrel is fixed by the locking block one and the mounting bracket, and the syringe plunger push plate is locked into the pull claw.

[0022] S2, Ampoule Processing Stage The crease piece is moved to the top of the target ampoule by the first cross slide, and after being aligned with the neck position, the vertical slide of the first cross slide moves the crease piece down, so that the cylinder is fitted on the outside of the ampoule neck.

[0023] During the descent of the creased part, the clamping ring on the outside of the cylinder squeezes the clamping block in the outer receiving groove of the placement groove through the annular inclined groove, causing the clamping block to slide towards the ampoule side and tightly press against the bottle body, thereby fixing the ampoule.

[0024] Start the motor to rotate the semi-circular inclined grinding wheel on the inner wall of the cylinder, and cut an annular crease at the neck of the ampoule. After cutting, turn off the motor.

[0025] The vertical slide of the control cross slide moves the creased part upward. During the upward movement, the rotating plate is blocked by the baffle on the sliding frame, causing the arc-shaped part to rotate around the torsion spring shaft. The U-shaped breaking frame on the inner wall breaks the neck of the ampoule with the ring crease. The broken neck and debris are intercepted by the operating table between the notch and the operating table.

[0026] S3, Drug Transfer and Mixing Stage The cross slide and electric pusher cylinder work together to move the mixing component and syringe to directly above the broken ampoule. The electric pusher cylinder is then lowered to insert the syringe needle into the ampoule. The electric slide is then activated to raise the pull claw, which pulls the syringe plunger to extract the liquid. After extraction, the syringe moves upward and is pulled out.

[0027] The syringe is moved directly above the target vial by the coordinated control of the cross slide and the electric plunger. The syringe is then lowered so that the needle is inserted into the vial. The electric slide is controlled to lower the pull claw, which pushes the syringe plunger to inject the liquid into the vial, thus achieving preliminary mixing of the liquid and powder. Alternatively, the syringe can be moved directly above the mixing bottle to inject the liquid into the mixing bottle.

[0028] If the vial mixing mode is used, after the liquid and powder of the medicine have fully dissolved in the vial, control the syringe to draw the mixture from the vial again, then move it directly above the mixing bottle and inject it into the mixing bottle.

[0029] If multiple medications need to be mixed, repeat the above ampoule processing and medication transfer steps, and inject all the required medications into the mixing bottle in sequence.

[0030] The electric bidirectional slide table is controlled to drive the placement platform and the operating platform to move back and forth over a short distance. This causes the trapezoidal mixing blocks on the side walls of the placement platform and the operating platform to push the crossbar of the locking component on the fixed frame, which in turn drives the upper locking component and the mixing bottle to move up and down repeatedly, thus achieving thorough mixing of the liquid in the mixing bottle.

[0031] S4, Final Stage After the medicine is mixed, the electric bidirectional slide table is controlled to move the placement platform and the operating platform away from each other. The magnetic plates on both sides of the slide table move to the top of the mounting cavity of the fixed frame. Through magnetic adsorption, the second card block rises and disengages from the limit groove, releasing the lock of the fixed frame. After opening the fixed frame, the mixing bottle is taken out.

[0032] Continue operating the electric bidirectional slide, which moves the placement platform and the operating platform to the drop outlets on both sides of the configuration platform. Used vials on the placement platform fall from placement slot two into the corresponding collection boxes; the ampoule bodies and broken debris on the operating platform fall from the drop outlets into the corresponding collection boxes.

[0033] Finally, after the gas purification equipment has been running for a period of time, it is turned off to complete the entire closed-loop preparation process of the chemotherapy drugs.

[0034] This invention provides a closed-loop preparation device and method for chemotherapy drugs. It has the following beneficial effects: 1. This invention constructs a closed operating environment through a sealed box, and is equipped with a gas purification device with activated carbon adsorption and photocatalytic purification functions, which can purify harmful gases generated during the preparation process in real time; the crease cutting, neck breaking, and drug transfer of the ampoule are all completed automatically by the mechanical structure, without the need for direct human contact, avoiding or reducing the skin, nerve and blood system damage caused by the biotoxicity of chemotherapy drugs to medical staff, and solving the contact risk problem of manual breaking of ampoules in the prior art.

[0035] 2. This invention relies on automated components such as cross slides, electric bidirectional slides, and electric push cylinders to achieve fully mechanized operations such as ampoule fixing-crease-breakage, vial / mixing bottle positioning, drug extraction-transfer-mixing, and automatic waste collection. It eliminates the need for manual intervention in core processes and can complete the mixing of multiple drugs through repeated operations, significantly reducing manual operation steps and time costs, and improving the efficiency and standardization of chemotherapy drug preparation.

[0036] 3. In the ampoule processing stage of this invention, the ampoule body is fixed by the cooperation of the clamping ring and the clamping block, the grinding wheel precisely cuts the annular crease, and the breaking frame directionally breaks the neck of the bottle to avoid leakage of the medicine; in the mixing stage, the trapezoidal mixing block pushes the fixing frame to move the mixing bottle up and down back and forth to ensure that the medicine is fully mixed; the fixing and pushing and pulling of the syringe are precisely controlled by the mechanical structure, the extraction and injection dosage is stable, effectively avoiding the error of manual operation and ensuring the accuracy and consistency of chemotherapy drug preparation.

[0037] 4. After the invention is configured, the electric bidirectional slide can move the placement platform and the operating platform to the drop outlet. The used vials, ampoules and broken fragments will automatically fall into the corresponding collection box, realizing the classified and centralized recycling of waste and avoiding the residue of fragments or the spread of pollutants. With the gas purification function of the sealed box, the operating environment is optimized from the aspects of solid waste and harmful gases, reducing the difficulty of subsequent cleaning and the risk of secondary pollution. Attached Figure Description

[0038] Figure 1 This is a schematic diagram of the overall structure of the present invention; Figure 2 This is another schematic diagram of the overall structure of the present invention; Figure 3 This is a schematic diagram of the fracture component structure of the present invention; Figure 4 This is a schematic diagram of the creased and broken parts of the present invention; Figure 5 This is a schematic diagram of the sliding frame and baffle of the present invention; Figure 6 This is a schematic diagram of the configuration platform structure of the present invention; Figure 7 For the present invention Figure 6 Enlarged view of point A; Figure 8 For the present invention Figure 6 Enlarged view of point B; Figure 9 This is a schematic diagram of the hybrid component structure of the present invention; Figure 10 This is another structural schematic diagram of the hybrid component of the present invention; Figure 11 This is a schematic diagram of the operating table structure of the present invention.

[0039] Among them, 1. Sealed box; 2. Configuration table; 3. Breaking component; 31. Operating table; 32. Placement slot one; 33. Cross slide one; 34. Crease part; 35. Breaking part; 311. Plate; 312. Rotating body; 341. Motor; 342. Cylinder; 343. Grinding wheel; 351. Arc-shaped part; 352. Rotating plate; 353. Sliding frame; 354. Baffle; 355. Breaking frame; 36. Receiving slot; 37. Clamping block; 38. Clamping ring; 4. Placement component; 41. 1. Placement platform; 42. Placement slot two; 5. Fixing component; 51. Fixing frame; 52. Slot; 53. Mixing block; 54. Mounting cavity; 55. Slot two; 56. Limiting slot; 57. Magnetic suction plate; 511. Lower sliding part; 512. Upper locking part; 513. Telescopic rod; 6. Cross slide two; 7. Electric push cylinder; 8. Mounting frame; 9. Mixing component; 91. Rotating frame; 92. Placement slot three; 93. Slot one; 94. Electric slide; 95. Pull claw; 10. Electric bidirectional slide. Detailed Implementation

[0040] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are merely some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0041] Example 1, please refer to the appendix. Figure 1 -Appendix Figure 4 This invention provides a closed-loop chemotherapy drug preparation device, comprising a sealed box 1, a preparation platform 2 fixedly disposed inside the sealed box 1, and drop openings on both sides of the preparation platform 2. The surface of the preparation platform 2 is provided with a breaking component 3 for breaking ampoules and a placement component 4 for placing vials. The breaking component 3 includes an operating table 31 slidably connected to the preparation platform 2. The surface of the operating table 31 has several placement slots 32. A cross slide 33 is fixedly disposed on the side wall of the operating table 31. A crease element 34 is mounted on the slider of the cross slide 33. The crease element 34 includes a motor 341, which is fixedly mounted on the slider of the cross slide 33. The drive end of the motor 341 is fixedly connected to a cylinder 342. A grinding wheel 343 is fixedly disposed on the inner wall of the cylinder 342. The grinding wheel 343 is semi-circular and inclined downwards. A breaking component 35 is mounted on the surface of the crease element 34. An opening is provided on the surface of the preparation platform 2, and an electric bidirectional slide is fixedly disposed inside the opening. The platform 10 and the placement component 4 include a placement platform 41 slidably connected to the configuration platform 2. The surface of the placement platform 41 is provided with several placement slots 42. Two sliders of the electric bidirectional slide 10 are fixedly connected to the placement platform 41 and the operating platform 31 respectively. The two sliders of the electric bidirectional slide 10 are L-shaped. A fixing component 5 for fixing the mixing bottle is provided on the opposite side of the placement platform 41 and the operating platform 31. A U-shaped placement rack is fixed at the center of the upper surface of the configuration platform 2 for receiving and unloading the mixing bottle. The sealed box 1 is provided with two sets of upper and lower boxes. Inside the sealed box 1, there are two collection boxes for collecting vials and ampoules respectively. Inside the sealed box 1, there is a gas purification device with activated carbon adsorption layer adsorption and photocatalytic purification functions. The gas purification device is existing technology and will not be described in detail here. The gas purification device draws in the harmful gases generated in the configuration process inside the sealed box 1 and decomposes them through activated carbon adsorption layer adsorption and photocatalytic purification components.

[0042] Specifically, in use, open the sealed box 1 and place the ampoules in the placement slot 32 in sequence. Before drawing the medicine from the ampoules, control the crease piece 34 to move to the neck of the ampoule directly above it using the cross slide, and make the grinding wheel 343 press against the neck of the ampoule. The motor 341 drives the grinding wheel 343 to rotate, creating a circular crease at the neck of the ampoule. Then, the neck of the ampoule is broken by the break piece 35, which automatically opens the ampoule to draw the medicine from it. No manual breaking is required, reducing the risk of contact.

[0043] When placing vials, the vials are placed sequentially inside the placement slot 42, ready for use. Before use, the electric bidirectional slide 10 moves the placement platform 41 and the operating platform 31 to the configuration platform 2. After use, the electric bidirectional slide 10 moves the placement platform 41 and the operating platform 31 to the drop outlet, so that the used ampoules and vials fall into the collection box. The operating platform 31 is L-shaped, which can intercept the fragments when the ampoule breaks, so that the fragments fall between the notch and the operating platform 31. When the operating platform 31 slides, it can push the fragments into the collection box, thereby achieving the effect of centralized collection and treatment of the used ampoules and their fragments.

[0044] Please see the appendix Figure 11 The operating table 31 includes a plate 311 and a rotating body 312, which are rotatably connected by a torsion spring shaft. Specifically, when the rotating body 312 moves to the drop outlet, it rotates downwards via a torsion spring shaft so that the debris on its surface can fall off more effectively.

[0045] Please see the appendix Figure 4 The outer side of the placement slot 32 is provided with several receiving slots 36, and the inside of the receiving slot 36 is provided with a pressing block 37. The outer side wall of the cylinder 342 is fixed with a pressing ring 38, and the inner bottom end of the pressing ring 38 is provided with an annular inclined groove. The diameter of the placement slot 32 is slightly larger than the diameter of the ampoule. Similarly, the diameter of the placement slot 42 is slightly larger than the diameter of the vial, which facilitates the falling of the vial.

[0046] Specifically, after the crease piece 34 descends above the ampoule, it contacts the outer apex of the clamping block 37 through the annular groove on the inner side of the clamping ring 38. During the descent, it pushes the clamping block 37 to one side of the ampoule until it is firmly pressed against the body of the ampoule, thus securing the ampoule and preventing the ampoule from rotating with the grinding wheel 343, which would result in incomplete creases.

[0047] Please see the appendix Figure 3 -Appendix Figure 4The lower side wall of the cylinder 342 has a notch. The break-off piece 35 includes an arc-shaped piece 351 located in the notch. A U-shaped break-off frame 355 is fixed on the inner wall of the arc-shaped piece 351. Rotating plates 352 are fixed on both sides of the arc-shaped piece 351. The rotating plates 352 are rotatably connected to the cylinder 342 through a torsion spring shaft. The torsion of the torsion spring causes the arc-shaped piece 351 to rotate and abut against the notch of the cylinder 342 to remain vertical while the rotating plates 352 remain horizontal. A pressing piece for pressing down the rotating plates 352 is installed on the surface of the cylinder 342.

[0048] Specifically, when the crease piece 34 moves to the neck of the ampoule directly above it, the neck of the ampoule passes through the break-off frame 355. After the crease piece 34 creates a crease, the pressing piece drives the end of the rotating plate 352 away from the arc-shaped piece 351 to move downwards, and drives the end of the rotating plate 352 close to the arc-shaped piece 351 to rotate upwards. This causes the rotating plate 352 to rotate and drives the arc-shaped piece 351 and the break-off frame 355 to rotate, so that the break-off frame 355 rotates to break the neck of the ampoule and throws the neck of the ampoule into the drop outlet for collection.

[0049] Please see the appendix Figure 3 -Appendix Figure 4 The pressing component includes a sliding frame 353, the height of which is higher than the height of the ampoule. The sliding frame 353 is located on the outside of the vertical slide of the cross slide 33 and is slidably connected to the operating table 31. A notch is provided on the surface of the sliding frame 353 corresponding to the rotating plate 352. A baffle 354 is rotatably connected below the notch via a torsion spring shaft. The sliding frame 353 moves laterally in sync with the vertical slide of the cross slide 33 under its pushing action.

[0050] Specifically, when the creased part 34 descends, the rotating frame 91 passes through the notch, the sliding frame 353, and the baffle 354. When it is necessary to break the ampoule, the cross slide 33 drives the creased part 34 to rise. When the rotating frame 91 rises, it is blocked by the baffle 354 and rotates, thereby causing the breaking frame 355 to break the ampoule.

[0051] In Example 2, unlike Example 1, the pressing component uses an electric push rod. By fixing the electric push rod to the outer wall of the cylinder 342 and above the end of the rotating plate 352 away from the arc-shaped component 351, the electric push cylinder 7 can press down on the rotating plate 352 through its driving end when it extends, thereby driving the rotating plate 352 to rotate, thus achieving the function of breaking the bottle body.

[0052] Example 3, please refer to the appendix. Figure 5 The fixing component 5 includes two L-shaped fixing brackets 51. The surface of the mounting platform 2 is provided with two sets of through grooves for slidingly connecting the two fixing brackets 51 respectively. A semi-circular slot 52 is provided on the opposite side of the two fixing brackets 51.

[0053] Specifically, when installing the mixing bottle, the electric bidirectional sliding table 10 operates to increase the distance between the placing table 41 and the operating table 31, so that the fixing frame 51 can slide open, so as to place the bottleneck of the mixing bottle in the card slot 52. Subsequently, after the ampoules and vials are placed, the electric bidirectional sliding table 10 runs in the reverse direction to reduce the distance between the placing table 41 and the operating table 31. At this time, the placing table 41 and the operating table 31 respectively push the two fixing frames 51 to slide and close, thereby fixing the mixing bottle.

[0054] Please refer to the appendix Figure 5 -appendix Figure 6 Inside the lower end of the fixing frame 51, a middle-shaped installation cavity 54 is opened. Inside the installation cavity 54, a T-shaped second clamping block 55 made of ferromagnetic material is slidably arranged. On the surface of the configuration table 2, a limiting groove 56 is opened on the moving track of the second clamping block 55. On both sides of the slider of the electric bidirectional sliding table 10, magnetic attraction plates 57 are respectively fixed. An elastic element is fixed between the upper surface of the second clamping block 55 and the inner top wall of the installation cavity 54 to improve the stability of the insertion of the second clamping block 55.

[0055] Specifically, when the fixing frame 51 slides and closes, the second clamping block 55 rotates to directly above the limiting groove 56, so that the second clamping block 55 can slide down and insert into the limiting groove 56, thereby locking the position of the fixing frame 51, so as to shake the mixing bottle subsequently. Then, after use, when the electric bidirectional sliding table 10带动 the placing table 41 and the operating table 31 to open and带动 the magnetic attraction plate 57 to move above the installation cavity 54, the second clamping block 55 is lifted by magnetic attraction, thereby canceling the clamping connection, so as to open the fixing frame 51 to take out the mixed mixing bottle.

[0056] Please refer to the appendix Figure 6 The fixing frame 51 includes two lower sliding parts 511 and an upper clamping part 512. An expansion rod 513 is fixed between the lower sliding part 511 and the upper clamping part 512. Trapezoidal mixing blocks 53 are respectively fixed on the side walls of the placing table 41 and the operating table 31. The upper clamping part 512 includes two L-shaped frames and a cross plate at the top of the two L-shaped frames. Cross bars are fixed on the lower side walls of the two L-shaped frames corresponding to the mixing blocks 53.

[0057] Specifically, when the liquid medicine needs to be mixed after being injected into the mixing bottle, the electric bidirectional sliding table 10带动 the placing table 41 and the operating table 31 to reciprocate a short distance, so that the cross bar of the upper clamping part 512 moves on the inclined surface of the mixing block 53, thereby带动 the upper clamping part 512 to reciprocate up and down, and带动 the mixing bottle to shake up and down, improving the mixing effect of the liquid medicine in the mixing bottle.

[0058] Example 4, please refer to the appendix Figure 9The inner top wall of the sealed box 1 is fixed with a cross slide 2 6, the slider of the cross slide 2 6 is fixed with an electric push cylinder 7, the drive end of the electric push cylinder 7 is fixed with an L-shaped mounting bracket 8, and the inside of the mounting bracket 8 is a mixing assembly 9 for fixing and pushing / pushing the syringe.

[0059] Specifically, the syringe is installed in the mixing assembly 9. The mixing assembly 9 can drive the syringe to move in multiple directions along the X, Y, and Z axes through the operation of the cross slide 2 6 and the electric cylinder. This allows the syringe to be moved to the ampoule to draw the drug solution, and then moved to the vial to inject the drug solution into the vial. The drug solution and powder are mixed in the vial and then transferred to the mixing bottle for further mixing. Alternatively, the drug solution can be directly injected into the mixing bottle. The specific usage method can be flexibly adjusted according to the preparation method of the chemotherapy drug, and there are no restrictions here.

[0060] Please see the appendix Figure 9 -Appendix Figure 10 The hybrid component 9 includes an L-shaped rotating frame 91 and an electric slide 94. One end of the rotating frame 91 is rotatably connected to the mounting frame 8, and the other end of the rotating frame 91 is detachably connected to the mounting frame 8 by means of snap-fit, plug-in or threaded connection. In this embodiment, the connection method of threaded connection is used for fixation. Specifically, a connection port is opened on the surface of the rotating frame 91 and a threaded hole is opened on the surface of the mounting frame 8. Fixing can be achieved by passing a bolt through the connection port and connecting it with the threaded hole. Semi-circular placement grooves 92 are respectively opened on the opposite ends of the rotating frame 91 and the mounting frame 8. A locking block 93 is fixed on the lower side wall of the rotating frame 91. The electric slide 94 is vertically fixed on the side wall of the mounting frame 8, and the slider of the electric slide 94 is fixed with a pull claw 95.

[0061] Specifically, in use, rotate and open the rotating frame 91, place the syringe barrel inside the placement slot 92, and then close the rotating frame 91. At this time, the first locking block 93 rotates to above the rear flange of the syringe barrel. The first locking block 93 cooperates with the mounting bracket 8 to fix the syringe barrel. The push plate of the syringe plunger rotates into the pull claw 95. The pull claw 95 is raised and lowered by the electric slide table 94, which can drive the syringe plunger and piston block to move up and down to realize the syringe aspiration operation.

[0062] Working principle: When in use, open the sealed box 1 and place the ampoules in the placement tank 32 in sequence. Before drawing the medicine from the ampoules, the crease piece 34 is moved to the neck of the ampoule directly above it by the cross slide, and the grinding wheel 343 is pressed against the neck of the ampoule. The motor 341 drives the grinding wheel 343 to rotate, creating a ring crease at the neck of the ampoule. The neck of the ampoule is then broken by the break piece 35, which automatically opens the ampoule to draw the medicine from it. No manual breaking is required, reducing the risk of contact. When placing vials, place them in the placement tank 42 in sequence and wait for use. Before use, the electric bidirectional slide 10 moves the placement platform 41 and the operating platform 31 to the configuration platform 2.

[0063] After the crease piece 34 descends above the ampoule, it contacts the outer apex of the clamping block 37 through the annular groove on the inner side of the clamping ring 38, pushing the clamping block 37 to one side of the ampoule until it tightly presses against the body of the ampoule, thus securing the ampoule and preventing the ampoule from rotating with the grinding wheel 343, which would result in incomplete creases. When the crease piece 34 moves to the neck of the ampoule directly above it, the neck of the ampoule passes through the break-off frame 355. After the crease piece 34 creates a crease, the pressing component drives the end of the rotating plate 352 away from the arc-shaped component 351 to move downward, and drives the end of the rotating plate 352 close to the arc-shaped component 351 to rotate upward, thereby causing the rotating component to rotate. This causes the break-off frame 355 to rotate and break the neck of the ampoule, and then throw the neck of the ampoule into the drop outlet for collection.

[0064] After use, the electric bidirectional slide 10 drives the placement platform 41 and the operating platform 31 to move to the drop outlet, so that the used ampoules and vials fall into the collection box. The operating platform 31 is L-shaped, which can intercept the fragments when the ampoule breaks, so that the fragments fall between the gap and the operating platform 31. When the operating platform 31 slides, it can push the fragments into the collection box, thereby achieving the effect of centralized collection and treatment of the used ampoules and their fragments.

[0065] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A closed preparation device for chemotherapy drugs, comprising a sealed box (1) with a gas purification device inside, wherein a preparation platform (2) is fixedly provided inside the sealed box (1), and drop-out openings are respectively provided on both sides of the preparation platform (2), characterized in that: The surface of the configuration platform (2) is provided with a breaking component (3) for breaking the ampoule; The breaking assembly (3) includes an operating table (31) slidably connected to the configuration table (2). The surface of the operating table (31) is provided with a plurality of placement slots (32). A cross slide (33) is fixedly provided on the side wall of the operating table (31). A crease piece (34) is installed on the slider of the cross slide (33). The crease piece (34) includes a motor (341). The motor (341) is fixedly installed on the slider of the cross slide (33). The driving end of the motor (341) is fixedly connected to a cylinder (342). A grinding wheel (343) is fixedly provided on the inner wall of the cylinder (342). A breaking piece (35) is installed on the surface of the crease piece (34).

2. The closed-loop preparation device for chemotherapy drugs according to claim 1, characterized in that: The lower side wall of the cylinder (342) has a notch, and the break-off piece (35) includes an arc-shaped piece (351) located in the notch. A U-shaped break-off frame (355) is fixed on the inner wall of the arc-shaped piece (351). Rotating plates (352) are fixed on both sides of the arc-shaped piece (351). The rotating plates (352) are rotatably connected to the cylinder (342) through a torsion spring shaft. A pressing member for pressing down the rotating plate (352) is installed on the surface of the cylinder (342).

3. The closed-loop preparation device for chemotherapy drugs according to claim 2, characterized in that: The pressing component includes a sliding frame (353), which is located on the outside of the vertical slide of the cross slide (33) and is slidably connected to the operating table (31). The surface of the sliding frame (353) has a notch corresponding to the rotating plate (352), and a baffle (354) is rotatably connected below the notch via a torsion spring shaft.

4. The closed preparation device for chemotherapy drugs according to claim 1, characterized in that: The surface of the configuration platform (2) has an opening, and the surface of the configuration platform (2) is equipped with a placement component (4) for placing vials. An electric bidirectional slide (10) is fixed inside the opening. The placement component (4) includes a placement platform (41) that is slidably connected to the configuration platform (2). The surface of the placement platform (41) has several placement slots (42). The two sliders of the electric bidirectional slide (10) are fixedly connected to the placement platform (41) and the operating platform (31) respectively. A fixing component (5) for fixing the mixing bottle is provided on the opposite side of the placement platform (41) and the operating platform (31). The fixing component (5) includes two L-shaped fixing brackets (51). The surface of the configuration platform (2) has two sets of sliding grooves for slidingly connecting the two fixing brackets (51) respectively. A semi-circular slot (52) is provided on the opposite side of the two fixing brackets (51).

5. The closed-loop preparation device for chemotherapy drugs according to claim 4, characterized in that: The lower end of the fixed frame (51) has a Chinese character-shaped mounting cavity (54). A T-shaped card block (55) made of ferromagnetic material is slidably arranged inside the mounting cavity (54). A limit groove (56) is opened on the surface of the configuration table (2) on the moving trajectory of the card block (55). Magnetic suction plates (57) are fixed on both sides of the slider of the electric bidirectional slide table (10).

6. The closed-loop preparation device for chemotherapy drugs according to claim 5, characterized in that: The fixed frame (51) includes two lower sliding parts (511) and an upper snap-fit ​​part (512), and a telescopic rod (513) is fixed between the lower sliding parts (511) and the upper snap-fit ​​part (512). The side walls of the placement platform (41) and the operating platform (31) are respectively fixed with trapezoidal mixing blocks (53).

7. The closed preparation device for chemotherapy drugs according to claim 1, characterized in that: The outer side of the placement groove (32) is provided with several receiving grooves (36), and a pressing block (37) is slidably provided inside the receiving groove (36). A pressing ring (38) is fixedly provided on the outer side wall of the cylinder (342), and an annular inclined groove is opened at the bottom inner side of the pressing ring (38).

8. The closed-loop preparation device for chemotherapy drugs according to claim 1, characterized in that: The inner top wall of the sealed box (1) is fixed with a cross slide two (6), the slider of the cross slide two (6) is fixed with an electric push cylinder (7), the drive end of the electric push cylinder (7) is fixed with an L-shaped mounting bracket (8), and the inside of the mounting bracket (8) is equipped with a hybrid assembly (9) for fixing and pushing / pushing the syringe.

9. A closed preparation device for chemotherapy drugs according to claim 8, characterized in that: The hybrid assembly (9) includes an L-shaped rotating frame (91) and an electric slide (94). One end of the rotating frame (91) is rotatably connected to the mounting frame (8), and the other end of the rotating frame (91) is detachably connected to the mounting frame (8). The rotating frame (91) and the mounting frame (8) are respectively provided with semi-circular placement slots (92). The lower side wall of the rotating frame (91) is fixed with a locking block (93). The electric slide (94) is vertically fixed to the side wall of the mounting frame (8), and the slider of the electric slide (94) is fixed with a pull claw (95).

10. A method for the closed-loop preparation of a chemotherapy drug, characterized in that, The method for a closed-system preparation device for chemotherapy drugs according to any one of claims 1-9 comprises: S1, Preparation Stage Open the sealed box (1) of the chemotherapy drug sealed configuration device, start the gas purification equipment with activated carbon adsorption layer adsorption and photocatalytic purification function in the box, and continuously purify the gas in the box. Place the ampoule containing chemotherapy solution into the first placement slot (32) of the operating table (31) in sequence, and place the vial containing powder into the second placement slot (42) of the placement table (41) in sequence. Control the operation of the electric bidirectional slide (10) to make the placement platform (41) and the operating platform (31) move away from each other, drive the two fixed frames (51) to slide open, place the mixing bottle on the U-shaped placement frame in the center of the configuration platform (2), and the neck of the mixing bottle corresponds to the semi-circular slot (52) of the two fixed frames (51); The electric bidirectional slide (10) is reversed, reducing the distance between the placement platform (41) and the operating platform (31), pushing the two fixed frames (51) closer to each other until they close, and clamping the neck of the mixing bottle through the slot (52); at this time, the second card block (55) in the mounting cavity (54) at the lower end of the fixed frame (51) slides down and inserts into the limiting slot (56) of the configuration platform (2) under the action of the elastic element, thus completing the fixing and locking of the mixing bottle; Open the rotating frame (91) of the mixing component (9), place the syringe in the placement slot three (92), close the rotating frame (91), so that the syringe barrel is fixed by the locking block one (93) and the mounting bracket (8), and the syringe plunger push plate is locked into the pull claw (95); S2, Ampoule Processing Stage The crease piece (34) is moved to the top of the target ampoule by the cross slide (33). After aligning with the neck position, the vertical slide of the cross slide (33) is controlled to drive the crease piece (34) to descend, so that the cylinder (342) is fitted on the outside of the neck of the ampoule. During the descent of the creased part (34), the clamping ring (38) on the outside of the cylinder (342) squeezes the clamping block (37) in the receiving groove (36) on the outside of the placement groove (32) through the annular inclined groove, so that the clamping block (37) slides towards the ampoule side and tightly abuts against the bottle body, thereby fixing the ampoule; Start the motor (341) to drive the semi-circular inclined grinding wheel (343) on the inner wall of the cylinder (342) to rotate, and cut an annular crease at the neck of the ampoule. After the cutting is completed, turn off the motor (341). The vertical slide of the control cross slide (33) drives the crease piece (34) to rise. During the rise, the rotating plate (352) is blocked by the baffle (354) on the sliding frame (353), which drives the arc-shaped piece (351) to rotate around the torsion spring shaft. The U-shaped breaking frame (355) on the inner wall breaks the neck of the ampoule with the ring crease. The broken neck and debris are intercepted by the operating table (31) between the notch and the operating table (31). S3, Drug Transfer and Mixing Stage The cross slide (6) and electric push cylinder (7) work together to move the mixing component (9) and syringe to the top of the broken ampoule. The electric push cylinder (7) is controlled to descend so that the syringe needle is inserted into the ampoule. The electric slide (94) is started to drive the pull claw (95) to rise and pull the syringe push rod to draw out the liquid. After the drawing is completed, the syringe moves upward and is pulled out. By coordinating the control of the cross slide (6) and the electric push cylinder (7), the syringe is moved to the top of the target vial, the syringe is lowered so that the needle is inserted into the vial, the electric slide (94) is controlled to drive the pull claw (95) to descend, and the syringe plunger is pushed to inject the liquid into the vial, so as to achieve the initial mixing of the liquid and powder; or the syringe is moved directly to the top of the mixing bottle and the liquid is injected into the mixing bottle. If the vial mixing mode is used, after the liquid and powder are fully dissolved in the vial, control the syringe to draw the mixture from the vial again, then move it directly above the mixing bottle and inject it into the mixing bottle; If multiple medications need to be mixed, repeat the above ampoule processing and medication transfer steps, and inject all the required medications into the mixing bottle in sequence; The electric bidirectional slide (10) drives the placement platform (41) and the operating platform (31) to move back and forth over a short distance, so that the trapezoidal mixing block (53) on the side wall of the placement platform (41) and the operating platform (31) pushes the crossbar of the snap-fit ​​part (512) on the fixed frame (51), which drives the snap-fit ​​part (512) and the mixing bottle to move up and down back and forth, so as to achieve full mixing of the medicine liquid in the mixing bottle; S4, Final Stage After the medicine is mixed, the electric bidirectional slide (10) is controlled to move the placement platform (41) and the operating platform (31) away from each other. The magnetic suction plates (57) on both sides of the slide move to the mounting cavity (54) above the fixed frame (51). Through magnetic adsorption, the second card (55) rises and disengages from the limiting groove (56), releasing the lock of the fixed frame (51). After opening the fixed frame (51), the mixing bottle is taken out. Continue to operate the electric bidirectional slide (10), which will move the placement platform (41) and the operating platform (31) to the drop outlets on both sides of the configuration platform (2). The used vials on the placement platform (41) will fall from the placement slot (42) into the corresponding collection box; the ampoule body and the broken debris on the operating platform (31) will fall from the drop outlet into the corresponding collection box. Finally, after the gas purification equipment has been running for a period of time, it is turned off to complete the entire closed-loop preparation process of the chemotherapy drugs.

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