Lipid composition, pharmaceutical composition comprising same, and uses thereof

CN121588232APending Publication Date: 2026-03-03TIANJIN QUANHECHENG TECH
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Patent Information

Application Number
CN202511629212.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2024-11-08
Filing Date
2025-11-07
Publication Date
2026-03-03

AI Technical Summary

Technical Problem

Existing lipid nanoparticle (LNP) delivery systems primarily target the liver, making it difficult to effectively target other organs, especially the lungs, thus impacting the treatment and prevention of lung diseases.

Method used

By adjusting the component structure and ratio of lipid compositions, especially by using a specific molar ratio of cationic lipids, steroidal lipids, and polyethylene glycol-modified lipids, a lung-targeting lipid composition was developed to carry the active pharmaceutical ingredient into the lungs.

Benefits of technology

This approach enables targeted delivery and accumulation of drugs in the lungs, improves nucleic acid expression and cell transfection efficiency in target organs, and provides a new approach to precision biological therapy for lung diseases.

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Abstract

The invention relates to the field of medical biology, and discloses a lipid composition, a pharmaceutical composition containing the lipid composition and application of the lipid composition and the pharmaceutical composition. The lipid composition provided by the invention can effectively deliver bioactive molecule drugs to the lung in a targeted manner, fills the blank of a lung targeted biological drug delivery system, and provides a new thought for developing and promoting the research progress of a precise biological therapy for lung diseases.
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Citation Information

Patent Citations

  • Cationic lipid compound, preparation method thereof, composition containing cationic lipid compound and application

    CN117964577A