Nerve-soothing slow-release aromatic medicine composition, preparation process and heating equipment
By using specific compositions and preparation processes, a sustained-release network of beeswax/fiber composite materials was prepared, which solved the problem of short-lasting fragrance in traditional Chinese medicine fragrances, achieving long-lasting sleep aid effects and high safety, and improving user compliance.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-11-06
- Publication Date
- 2026-03-06
AI Technical Summary
Existing Chinese herbal incense has a short fragrance retention time, and the chitosan inclusion technology makes it difficult for the fragrance to volatilize properly, thus limiting its ability to continuously promote sleep and its application.
A sustained-release network of beeswax/fiber composite material is formed by using a specific ratio of lavender, sweet flag, polygala, beeswax, amber, ginseng, nard, patchouli, and euphorbia pekinensis, combined with gradient temperature cooling and ultrasonic-assisted dispersion, and prepared using specially designed heating equipment.
It has increased the aroma volatilization time from 1-2 weeks to more than 1 month, with a cumulative release rate of 93.6%-98.8%, shortened sleep onset time, improved sleep quality, high safety, and good user compliance.
Smart Images
Figure CN121606648A_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of sedative drugs, and particularly relates to a sedative sustained-release aromatic drug composition, its preparation process, and heating equipment. Background Technology
[0002] Due to the fast pace of social development and increasing work and life pressures, insomnia is becoming increasingly common among the population.
[0003] Current methods for improving insomnia have significant limitations: self-regulation relies on the patient's subjective cooperation and has limited effectiveness; Western sedative-hypnotic drugs are prone to causing drug tolerance and dependence. Traditional Chinese medicine (TCM) aromatherapy products have become a preferred option due to their ability to improve sleep quality, synergistically combat anxiety and depression, and their ease of use, safety, and good compliance. However, existing aromatherapy products have a key drawback—short fragrance duration. The aromas of calming herbs such as ginseng, calamus, and nard dissipate within 24-72 hours. While non-TCM encapsulation technologies such as chitosan can prolong fragrance duration, they also prevent the aroma from evaporating properly, hindering its sustained sleep-aiding effect and severely limiting the widespread application of TCM aromatherapy products. Summary of the Invention
[0004] The purpose of this invention is to provide a sedative sustained-release aromatic drug composition, a preparation process, and a heating device. This invention has the advantages of maintaining an effective concentration for long-term sleep aid, high safety, and good user compliance.
[0005] The technical solution of the present invention: a calming and sustained-release aromatic drug composition, comprising, by weight, 1-2.2 parts of lavender volatile oil, 0.4-1 parts of calamus volatile oil, 0.4-1 parts of polygala volatile oil, 30-40 parts of beeswax, 15-25 parts of amber, 4-6 parts of ginseng, 4-8 parts of nard, 8-12 parts of patchouli, and 15-30 parts of agastache rugosa.
[0006] The aforementioned sedative and sustained-release aromatic drug composition includes 2 parts lavender volatile oil, 0.5 parts calamus volatile oil, 0.5 parts polygala volatile oil, 37 parts beeswax, 20 parts amber, 5 parts ginseng, 5 parts nard, 10 parts patchouli, and 20 parts agastache.
[0007] The aforementioned preparation process of the sedative sustained-release aromatic drug composition includes the following steps: Step a: After the amber and ginseng are crushed, they are mixed with spikenard, patchouli, and lingzhi to obtain product A; Step b: Add molten beeswax to product A to obtain product B; Step c: Add lavender volatile oil, sweet flag volatile oil and polygala volatile oil to product B to obtain product C; Step d: Heat and stir product C to obtain product D; Step e: After cooling product D, it is crushed at low temperature to obtain the finished drug composition.
[0008] In the aforementioned preparation process of the sedative sustained-release aromatic drug composition, in step e, product D is ultrasonically dispersed and then cooled.
[0009] In the aforementioned preparation process of the sedative sustained-release aromatic drug composition, in step e, product D is ultrasonically dispersed and then cooled at a gradient temperature.
[0010] In the aforementioned preparation process of the sedative sustained-release aromatic drug composition, in step e, after product D is crushed, it is passed through a 40-60 mesh sieve to obtain the finished aromatic drug product.
[0011] The heating equipment for implementing the aforementioned preparation process, used in steps a to d, includes an upper hemisphere and a lower hemisphere, with a hopper formed between the upper and lower hemispheres. A stirring head is provided inside the hopper. A feed valve and a drive mechanism connected to the stirring head are provided at the top of the upper hemisphere. An insulation layer is provided at the bottom of the lower hemisphere. An interlayer is formed between the insulation layer and the lower hemisphere. A heating mechanism is provided inside the interlayer. Support feet are provided at the bottom of the insulation layer.
[0012] In the aforementioned heating device, one side of the upper hemisphere and one side of the lower hemisphere are hinged together, and a locking mechanism is provided between the upper and lower hemispheres; the driving mechanism includes a motor fixed to the upper hemisphere, and the output end of the motor is connected to a stirring head through a stirring shaft. The stirring head is an anchor-type stirrer, and the gap between the stirring head and the inner wall of the lower hemisphere is less than 5mm.
[0013] In the aforementioned heating device, the heating mechanism is an electric heating tube located inside the interlayer, and a controller connected to the electric heating tube is provided outside the interlayer. The controller is connected to a temperature sensor and a display screen, and the detection end of the temperature sensor is located inside the interlayer.
[0014] In the aforementioned heating device, a sealing ring is provided between the upper hemisphere and the lower hemisphere, a pressure relief valve is provided at the top of the upper hemisphere, and a discharge valve extending out of the insulation shell is provided at the bottom of the lower hemisphere.
[0015] Compared with existing technologies, this invention has the following advantages through optimization of the ratio of beeswax and traditional Chinese medicine raw materials and design of the preparation process: First, the fragrance release time of the incense has been extended from the traditional 1-2 weeks to more than 1 month. In vitro release tests show that the cumulative release rate reaches 93.6%-98.8% within 720 hours, with no sudden release phenomenon, and it can maintain an effective concentration for sleep aid for a long time.
[0016] Secondly, human trials (N=60) showed that after wearing the device for 7 days, the improvement rate of falling asleep time shortened by ≥30 minutes reached 76.7%-86.7%, the improvement rate of sleep quality score (PSQI scale) reached 68.3%-78.3%, and the incidence of adverse reactions was only 1.7%-3.3%, indicating high safety.
[0017] Third, all raw materials are Chinese medicine or Chinese medicine volatile oils, without chitosan or other non-Chinese medicine encapsulation materials, avoiding foreign body irritation and ensuring good user compliance.
[0018] In summary, this invention has the advantages of maintaining an effective concentration for long-term sleep aid, high safety, and good user compliance. Attached Figure Description
[0019] Figure 1 This is a front view schematic diagram of the heating equipment.
[0020] Figure 2 This is a top view of the locking mechanism.
[0021] Figure 3 This is a connection diagram of the controller.
[0022] The labels in the attached diagram are as follows: 1-Upper hemisphere, 2-Lower hemisphere, 3-Hopper, 4-Agitator head, 5-Feed valve, 6-Insulation shell, 7-Jack, 8-Support leg, 9-Motor, 10-Agitator shaft, 11-Heating element, 12-Controller, 13-Temperature sensor, 14-Display screen, 15-Sealing ring, 16-Pressure relief valve, 17-Locking mechanism, 18-Discharge valve, 19-Oil filler port, 20-Hinge. Detailed Implementation
[0023] The present invention will be further described below with reference to the accompanying drawings and embodiments, but this should not be construed as limiting the present invention.
[0024] Example 1: A heating device, such as Figure 1 As shown, it includes an upper hemispherical shell 1 and a lower hemispherical shell 2. A sealing ring 15 is provided between the upper hemispherical shell 1 and the lower hemispherical shell 2. A 10-liter hopper 3 is formed between the upper hemispherical shell 1 and the lower hemispherical shell 2. A stirring head 4 is provided in the hopper 3. The stirring head 4 is an anchor-type stirrer. The gap between the stirring head 4 and the inner wall of the lower hemispherical shell 2 is less than 5mm.
[0025] The top of the upper hemispherical shell 1 is equipped with a feed valve 5, a drive mechanism connected to the stirring head 4, and a pressure relief valve 16. The drive mechanism includes a motor 9 fixed to the upper hemispherical shell 1, and the output end of the motor 9 is connected to the stirring head 4 through a stirring shaft 10. The motor 9 is preferably a variable frequency speed control motor with a speed range of 50-600 r / min.
[0026] One side of the upper hemisphere 1 and one side of the lower hemisphere 2 are hinged by a hinge 20, and a locking mechanism 17 is provided between the upper hemisphere 1 and the lower hemisphere 2. The locking mechanism 17 can be made of six latches or six hand-tightening bolts, which pass through the outer edge of the upper hemisphere 1 and are screwed to the outer edge of the lower hemisphere 2.
[0027] The lower hemispherical shell 2 has a spherical insulation shell 5 at its bottom, forming a sandwich 7 between the insulation shell 5 and the lower hemispherical shell 2. A heating mechanism, consisting of two electric heating tubes 11 located within the sandwich 7, is installed inside the sandwich 7. Several supporting feet 8 are provided at the bottom of the insulation shell 5. A discharge valve 18 extending from the bottom of the lower hemispherical shell 2 out of the insulation shell 5 is also provided. Preferably, an oil filling port 19 is provided at the top of the insulation shell 5, through which heat-conducting oil is injected into the sandwich 7, ensuring uniform temperature of the lower hemispherical shell 2 and uniform heating of the internal material, thus reducing the loss of effective components due to overheating.
[0028] Preferably, a controller 12 is provided outside the interlayer 7. The controller 12 can be an FX2N series PLC. A temperature sensor 13 and a display screen 14 are connected to the controller 12. The detection end of the temperature sensor 13 is located inside the interlayer 7. The heating element 11 is connected to the relay output terminal of the controller 12, the temperature sensor 13 is connected to the signal input terminal of the controller 12, and the display screen 14 is connected to the signal output terminal of the controller 12. The heating temperature is set by the controller 12. When the temperature sensor 13 detects that the internal temperature of the interlayer 7 exceeds the set heating temperature, the controller 12 disconnects the heating element 11 to stop heating. When the temperature sensor 13 detects that the internal temperature of the interlayer 7 is lower than the set heating temperature, the controller 12 energizes the heating element 11 to reheat. The temperature detected by the temperature sensor 13 is displayed on the display screen 14.
[0029] Example 2: A sedative and sustained-release aromatic drug composition, characterized in that, by weight, it comprises 2 parts lavender volatile oil, 0.5 parts calamus volatile oil, 0.5 parts polygala volatile oil, 37 parts beeswax, 20 parts amber, 5 parts ginseng, 5 parts nard, 10 parts patchouli, and 20 parts agastache.
[0030] The functions of each component are as follows: Acorus tatarinowii volatile oil: calms the mind and improves intelligence; Lavender volatile oil: calms the nerves and soothes the nerves; Ginseng: invigorates qi and calms the nerves; Amber: calms the nerves and soothes the nerves; Nardostachys jatamansi: regulates qi and relieves depression; Eupatorium fortunei: regulates qi and opens the orifices; Patchouli: regulates qi and relieves chest congestion; Beeswax: controlled release carrier.
[0031] Example 3: A sedative and sustained-release aromatic drug composition, characterized in that: by weight, it comprises 1 part lavender volatile oil, 1 part calamus volatile oil, 1 part polygala volatile oil, 33 parts beeswax, 15 parts amber, 4 parts ginseng, 8 parts nard, 12 parts patchouli, and 25 parts agastache.
[0032] Example 4: A sedative and sustained-release aromatic drug composition, characterized in that: by weight, it comprises 1.2 parts of lavender volatile oil, 0.8 parts of calamus volatile oil, 0.5 parts of polygala volatile oil, 30 parts of beeswax, 18 parts of amber, 4.5 parts of ginseng, 5 parts of nard, 10 parts of patchouli, and 30 parts of linglingxiang.
[0033] Example 5: A preparation process for any one of the sedative sustained-release aromatic drug compositions in Examples 2 to 4, wherein the process is combined with the heating device of Example 1: including the following steps, Step a: After the amber and ginseng are crushed, they are mixed with spikenard, patchouli and lingling spice to obtain product A. Product A enters the silo 3 through the feed valve 5.
[0034] Step b: Melt the beeswax. The beeswax enters the hopper 3 through the feed valve 5 and mixes with product A to obtain product B. Step c: Lavender volatile oil, sweet flag volatile oil and polygala volatile oil enter the silo 3 through the feed valve 5 and are mixed with product B to obtain product C; Step d: Heat and stir product C at 60°C, with stirring head 4 rotating at 300 r / min for 30 min to obtain product D; Step e: Product D is discharged from discharge valve 18 and subjected to ultrasonic treatment to make the plant fiber distribution in beeswax more uniform, resulting in D1; D1 is subjected to gradient temperature cooling with a gradient set at 20°C. For example, it is first placed in an environment of 40°C and naturally cooled to 45°C, then placed in an environment of 20°C and naturally cooled to 25°C, then placed in an environment of 0°C and naturally cooled to 5°C, then placed in an environment of -20°C and naturally cooled to -15°C, and then placed in an environment of -40°C and naturally cooled to about -35°C, resulting in product D2; Product D2 is crushed and passed through a 40-60 mesh sieve to obtain the finished product of the pharmaceutical composition.
[0035] Gradient cooling allows beeswax / fiber composites, with fibers derived from spikenard, tonka bean, and patchouli, to form an organic porous slow-release network.
[0036] Low-temperature crushing aims to achieve efficient crushing without softening or melting beeswax during the crushing process. At low temperatures, the surface tension of beeswax is reduced, making it less likely to stick to the equipment cavity during crushing. This extends the equipment cleaning cycle by 3 to 5 times and avoids uneven particle size caused by adhesion (the particle size deviation of traditional room temperature crushing can reach 30%, while the deviation of low-temperature crushing is ≤5%).
[0037] The purpose of using the heating device of Example 1 is that the heating device has high temperature control accuracy, uniform heating, and is not prone to damage to the activity of volatile oils due to local overheating; it has good sealing performance, reducing the impact of essential oil volatilization loss on product efficacy; it stirs evenly, improving the stability of aroma slow release; and the device is easy to open and clean, simply by opening the locking mechanism 17.
[0038] Test Example 1: Examples 2 to 4 were all obtained using the process of Example 5. The three finished products were tested and the results are shown in Table 1 and Table 2 below.
[0039] Table 1: Evaluation of human trial effects (N=60, double-blind randomized controlled trial, 7 days of wear) As can be seen from Table 1, Example 2 showed the most significant effect and had a low incidence of adverse reactions.
[0040] Table 2: In vitro release rate test data (simulated wearing environment, temperature 32±2℃, relative humidity 60%) As shown in Table 2, Example 2 maintained a long-lasting release while exhibiting the smallest deviation in release rate over a 720-hour period. The released components were mainly terpenoid compounds, including linalool, β-caryophyllene, and patchouli alcohol.
[0041] Test Example 2: Two commercially available ordinary incense holders were randomly purchased and compared with the finished product of Example 2. The results are shown in Table 3.
[0042] Table 3: Comparison of sustained-release performance (compared with commercially available ordinary fragrance products) As can be seen from Table 3, the release rate of the finished product of Example 2 is more gradual, and it can maintain its use for a longer period of time.
[0043] Test Example 3: As shown in Table 4, the formulation of Example 2 was used to prepare the finished product using both the traditional mixing method and the microencapsulation method, with the processes denoted as P1 and P2, respectively; the formulation of Example 2 was used to prepare the finished product according to the process of Example 5, with the process denoted as P3. The three finished products were tested, and the results are shown in Table 5. Table 4: Different preparation process parameter settings (constant ratio, process variables) Table 5: Comparison of in vitro release rates under different processes (cumulative release rate %) As can be seen from Table 5, P1 releases too quickly and has a short effective duration; although P2 can maintain release for a long time, its release concentration is too low and it cannot effectively aid sleep; however, under the preparation process of this invention, the active ingredient can be maintained for a long time and released within a certain effective concentration range.
Claims
1. A mental tranquillity sustained release necklace pharmaceutical composition characterized in that: By weight parts, including lavender volatile oil 1~2.2 parts, Acorus volatile oil 0.4~1 parts, Polygala volatile oil 0.4~1 parts, beeswax 30~40 parts, amber 15~25 parts, ginseng 4~6 parts, sweetcane 4-8 parts, Agastache 8~12 parts, Zerumbet 15~30 parts.
2. The nervine sustained release necklace pharmaceutical composition as claimed in claim 1, wherein: Including lavender volatile oil 2 parts, Acorus volatile oil 0.5 parts, Polygala volatile oil 0.5 parts, beeswax 37 parts, amber 20 parts, ginseng 5 parts, sweetcane 5 parts, Agastache 10 parts, Zerumbet 20 parts.
3. The process for the preparation of the Nerves calm extended release fragrance medicine composition as claimed in claim 1 or 2, wherein: Including the following steps, Step a: after the crushing treatment of amber and ginseng, mixed with sweetcane, Agastache, Zerumbet, A product is obtained; Step b: the melted state of beeswax is added to the A product, and the B product is obtained; Step c: lavender volatile oil, Acorus volatile oil and Polygala volatile oil are added to the B product, and the C product is obtained; Step d: the C product is heated and stirred, and the D product is obtained; Step e: after the D product is cooled, it is broken at low temperature, and the finished product of the medicine composition is obtained.
4. The process for the preparation of Nervesan slow release fragrance medicine composition as claimed in claim 3, wherein: In the step e, the D product is dispersed with ultrasonic assistance and then cooled.
5. The process for the preparation of Nervesan slow release fragrance medicine composition as claimed in claim 4, wherein: In the step e, the D product is dispersed with ultrasonic assistance and then cooled at gradient temperature.
6. The process for the preparation of Nervesan slow release fragrance medicine composition as claimed in claim 3, wherein: In the step e, the D product is broken, and then passed through a 40-60 mesh sieve to obtain the finished product of the medicine.
7. A heating apparatus for carrying out the production process according to claim 3, characterized in that: The heating device used in steps a to d includes an upper hemisphere shell (1) and a lower hemisphere shell (2), a material bin (3) is formed between the upper hemisphere shell (1) and the lower hemisphere shell (2), a stirring head (4) is arranged in the material bin (3), a feeding valve (5) is arranged at the top of the upper hemisphere shell (1), and a driving mechanism connected with the stirring head (4) is arranged at the top of the upper hemisphere shell (1); a heat preservation shell (5) is arranged at the bottom of the lower hemisphere shell (2), a layer (7) is formed between the heat preservation shell (5) and the lower hemisphere shell (2), a heating mechanism is arranged in the layer (7), and supporting feet (8) are arranged at the bottom of the heat preservation shell (5).
8. The heating apparatus of claim 7, wherein: One side of the upper hemisphere shell (1) and one side of the lower hemisphere shell (2) are hingedly connected, and a locking mechanism (17) is arranged between the upper hemisphere shell (1) and the lower hemisphere shell (2); the driving mechanism includes a motor (9) fixed to the upper hemisphere shell (1), an output end of the motor (9) is connected with the stirring head (4) through a stirring shaft (10), the stirring head (4) is an anchor stirrer, and the gap between the stirring head (4) and the inner wall of the lower hemisphere shell (2) is less than 5 mm.
9. The heating apparatus of claim 7, wherein: The heating mechanism is an electric heating pipe (11) arranged in the layer (7), a controller (12) connected with the electric heating pipe (11) is arranged outside the layer (7), a temperature sensor (13) and a display screen (14) are connected to the controller (12), and the detection end of the temperature sensor (13) is arranged in the layer (7).
10. The heating apparatus of claim 7, wherein: A sealing rubber ring (15) is arranged between the upper hemisphere shell (1) and the lower hemisphere shell (2), a pressure relief valve (16) is arranged at the top of the upper hemisphere shell (1), and a discharging valve (18) extending out of the heat preservation shell (5) is arranged at the bottom of the lower hemisphere shell (2).