Noninvasive detection module, intelligent device and noninvasive detection method

Abstract

The invention discloses a non-invasive detection module, intelligent equipment and a non-invasive detection method.The non-invasive detection module comprises a light emitter, a first nanometer unit, a second nanometer unit and a light receiver, the first nanometer unit, the second nanometer unit and the light receiver are located at the light emitting end of the light emitter, and the first nanometer unit is configured to focus light waves emitted by the light emitter to a to-be-detected part; the first nano unit is configured to excite a Raman scattering signal, the second nano unit is configured to collect the Raman scattering signal, and the light receiver is configured to receive the Raman scattering signal collected by the second nano unit to obtain a Raman spectrum of the to-be-detected part. According to the non-invasive detection module provided by the invention, due to the adoption of the first nano unit and the second nano unit, the size of the non-invasive detection module can be smaller, so that the size of the non-invasive detection module is smaller than that of Raman spectrum equipment in related technologies, and the non-invasive detection module can be integrated into a terminal product; daily detection requirements can be met, and non-invasive detection is more convenient and faster.

Description

Technical Field

[0001] This application relates to the field of biosensor technology, and in particular to a non-invasive detection module, intelligent device, and non-invasive detection method. Background Technology

[0002] Currently, invasive or minimally invasive methods are still commonly used for blood glucose testing, requiring the collection of small amounts of blood and the use of reagents. Interstitial fluid, sweat, saliva, and tears are considered potential biofluids for tracking glucose levels, and their glucose concentrations correlate with blood glucose concentrations, suggesting potential applications for non-invasive blood glucose testing. However, these potential biofluids are affected by environmental factors (such as temperature and pH) and ingestion, and are easily contaminated by other biomarkers or old sweat, requiring further verification of their accuracy and stability. Some scholars have pointed out that light is an ideal information carrier for non-invasive testing. Blood glucose testing based on photoacoustic analysis and Raman spectroscopy can avoid the influence of environmental factors, potentially achieving more accurate and stable non-invasive blood glucose testing.

[0003] Raman scattering is an inelastic scattering process where light passing through a transparent medium is scattered by molecules, causing a change in the light frequency, thus producing Raman scattering. The wavelength of Raman scattered light is determined by the chemical structure of the medium and is related to the molecular structure, vibrations, and rotations of the medium. Different molecular structures can produce Raman spectra with different characteristic peaks, and the intensity of the Raman spectrum has a linear relationship with the substance content. Therefore, blood glucose analysis can be performed using Raman spectroscopy. However, Raman spectroscopy places high demands on Raman signal detection devices. Currently, the Raman detection devices required for biological detection are relatively large, even requiring large instruments, and are cumbersome to operate, demanding a high level of expertise. They are not consumer-grade products, let alone integrated into end products (such as mobile terminals, wearable devices, etc.), making it difficult to meet the needs of convenient and quick daily testing. Summary of the Invention

[0004] This application discloses a non-invasive detection module and intelligent device, which can make the size of the Raman signal detection device relatively small, thereby enabling the Raman signal detection device to be integrated into the terminal product, which is beneficial to meeting daily detection needs and making non-invasive detection more convenient and faster.

[0005] To achieve the above objectives, in a first aspect, embodiments of this application disclose a non-invasive detection module, comprising:

[0006] Light emitter;

[0007] The first nanounit is located at the light-emitting end of the light emitter and is configured to focus the light wave emitted by the light emitter onto the part to be measured in order to excite the Raman scattering signal.

[0008] A second nanounit, configured to collect the Raman scattering signal; and

[0009] A light receiver is configured to receive the Raman scattering signal collected by the second nanounit to obtain the Raman spectrum of the test site.

[0010] As an optional implementation, the first nanounit includes a first collimation section, a first filtering section, and a first focusing section. The first collimation section, the first filtering section, and the first focusing section are disposed along the light-emitting end of the light emitter. The first collimation section is configured to collimate the light wave, the first filtering section is configured to filter the light wave, and the first focusing section is configured to focus the filtered light wave onto the region to be measured to excite the Raman scattering signal.

[0011] As an optional implementation, the first focusing part and the first filtering part are arranged at intervals along the emission direction of the light wave;

[0012] The first collimation section and the first filtering section are integrally formed; or...

[0013] The first collimating section and the first filtering section are spaced apart, such that the first filtering section is located between the first collimating section and the first focusing section.

[0014] As an optional implementation, the second nanounit includes a second collimator, a second filter, a beam splitter, and a second focusing unit. The second collimator, the second filter, the beam splitter, and the second focusing unit are arranged along the transmission direction of the Raman scattering signal. The second collimator is configured to collimate the Raman scattering signal, the second filter is configured to filter the Raman scattering signal, the beam splitter is configured to separate signals of different wavelengths in the filtered Raman scattering signal along a first direction, and the second focusing unit is configured to focus signals of the same wavelength to the same position of the optical receiver.

[0015] Wherein, the first direction is the direction that intersects with the direction of the Raman scattering signal.

[0016] As an optional implementation, the second focusing part and the beam splitting part are arranged at intervals along the transmission direction of the Raman scattering signal;

[0017] At least two of the second collimating section, the second filtering section, and the beam splitter are integrally arranged, or the second collimating section, the second filtering section, and the beam splitter are arranged sequentially at intervals along the transmission direction of the Raman scattering signal.

[0018] As an optional implementation, the non-invasive detection module further includes a substrate assembly, the substrate assembly including a first substrate, the light emitter and the light receiver being disposed at intervals on the first substrate, and the first nanounit and the second nanounit being at least partially disposed on the first substrate.

[0019] As an optional implementation, the substrate assembly further includes a second substrate, which is located at the light-emitting end of the light emitter and is spaced apart from the first substrate.

[0020] The first nanounit includes a first collimating section, a first filtering section, and a first focusing section disposed along the emission direction of the light wave. The first collimating section and the first filtering section are disposed on the first substrate and are disposed corresponding to the light emitter. The first focusing section is disposed on the second substrate and is disposed corresponding to the first filtering section. The first collimating section is configured to collimate the light wave, the first filtering section is configured to filter the light wave, and the first focusing section is configured to focus the filtered light wave onto the test site to excite the Raman scattering signal.

[0021] The second nanounit includes a second collimating section, a second filtering section, a beam splitter, and a second focusing section disposed along the transmission direction of the Raman scattering signal. The second focusing section is disposed on the second substrate and corresponding to the light receiver, and the second focusing section is spaced apart from the first focusing section. The second collimating section, the second filtering section, and the beam splitter are disposed on the second substrate and located between the second focusing section and the first focusing section. The second collimating section is configured to collimate the Raman scattering signal, the second filtering section is configured to filter the Raman scattering signal, the beam splitter is configured to separate signals of different wavelengths in the filtered Raman scattering signal along a first direction, and the second focusing section is configured to focus signals of the same wavelength to the same position of the light receiver.

[0022] Wherein, the first direction is the direction that intersects with the transmission direction of the Raman scattering signal.

[0023] As an optional implementation, the first collimation section and the first filtering section are integrally disposed; and / or,

[0024] The second collimation section, the second filtering section, and the beam splitting section are at least two integrally arranged.

[0025] As an optional implementation, the second nanounit further includes a first deflection portion, which is disposed on the first substrate and corresponding to the second collimation portion, and is located between the first collimation portion and the light receiver. The first deflection portion is configured to deflect the Raman scattering signal by a deflection angle.

[0026] The reflective portion includes a first sub-reflective portion and a second sub-reflective portion. The first sub-reflective portion is disposed on the second substrate and is located between the beam splitter and the second focusing portion. The second sub-reflective portion is disposed on the first substrate and is located between the first deflection portion and the light receiver.

[0027] The second deflection section is disposed on the second substrate corresponding to the light receiver, and is disposed upstream of the second focusing section along the transmission direction of the Raman scattering signal. The second deflection section is configured to reflect the Raman scattering signal to the second focusing section by a deflection angle.

[0028] As an optional implementation, the second deflection part and the second focusing part are integrally disposed; or,

[0029] The second deflection section and the second focusing section are spaced apart.

[0030] As an optional implementation, the reflective portion includes multiple sets, and the multiple sets of reflective portions are sequentially disposed between the first deflecting portion and the second deflecting portion along the second direction;

[0031] The second direction is the direction in which the light emitter points towards the light receiver.

[0032] As an optional implementation, the substrate assembly further includes a second substrate and a third substrate, the second substrate and the third substrate being located at the light-emitting end of the light emitter, and the first substrate, the second substrate and the third substrate being arranged sequentially along the emission direction of the light wave;

[0033] The first nanounit includes a first collimating section, a first filtering section, and a first focusing section arranged sequentially along the emission direction of the light wave. The first collimating section is disposed on the first substrate corresponding to the light emitter; the first filtering section is disposed on the second substrate corresponding to the first collimating section; and the first focusing section is disposed on the third substrate corresponding to the first filtering section. The first collimating section is configured to collimate the light wave, the first filtering section is configured to filter the light wave, and the first focusing section is configured to focus the filtered light wave onto the test site to excite the Raman scattering signal.

[0034] The second nanounit includes a second collimator, a second filter, a beam splitter, and a second focusing unit sequentially disposed along the transmission direction of the Raman scattering signal. The second collimator, the second filter, and the beam splitter are disposed on the first substrate corresponding to the light receiver, and the beam splitter is spaced apart from the first focusing unit. The second focusing unit is disposed on the second substrate corresponding to the beam splitter, and the second focusing unit is spaced apart from the first filter unit. The second collimator is configured to collimate the Raman scattering signal, the second filter is configured to filter the Raman scattering signal, the beam splitter is configured to separate signals of different wavelengths in the filtered Raman scattering signal along a first direction, and the second focusing unit is configured to focus signals of the same wavelength onto the light receiver.

[0035] Wherein, the first direction is the direction that intersects with the direction of the Raman scattering signal.

[0036] As an optional implementation, at least two of the second collimation section, the second filtering section, and the beam splitter are integrally arranged.

[0037] As an optional implementation, the optical receiver and the optical transmitter are spaced apart along a second direction, and the distance between the optical receiver and the optical transmitter in the second direction is 200 μm to 5 mm; and / or,

[0038] The first nanounit and the second nanounit are spaced apart along a second direction, and the spacing between the first nanounit and the second nanounit along the second direction is 200 μm to 5 mm; and / or,

[0039] A blocking portion is provided between the first nanounit and the second nanounit, and the blocking portion is configured to prevent light from the first nanounit from being reflected to the second nanounit.

[0040] The second direction is the direction in which the light emitter points towards the light receiver.

[0041] As an optional implementation, the substrate assembly may be made of glass, polymethyl methacrylate, or plastic; and / or,

[0042] The first nanounit and the second nanounit are etched and formed on the substrate assembly.

[0043] As an optional implementation, the passband width of the first filter section is in the range of 0.1nm to 0.5nm, and the optical density value of the first filter section is ≥2.

[0044] As an optional implementation, the band-stop range of the second filter section at least covers the wavelength portion of the light wave.

[0045] As an optional implementation, the first nanounit and the second nanounit comprise a plurality of arranged nanocylindrical structures, wherein the base radius and height of the nanocylindrical structures are both less than 500 nm; and / or,

[0046] The material of the nanocylindrical structure includes, but is not limited to, TiO2; and / or,

[0047] The center wavelength of the light wave is 500nm to 1800nm; and / or,

[0048] The spectral width of the light wave is 0.1 nm to 50 nm.

[0049] As an optional implementation, the optical receiver includes a plurality of optical receivers arranged around the optical transmitter;

[0050] The second nanounit corresponds to multiple light receivers, and the multiple second nanounits are arranged around the first nanounit on the outer periphery of the first nanounit.

[0051] Secondly, embodiments of this application also disclose an intelligent device, which includes a device body and a non-invasive detection module as described in the first aspect above, wherein the non-invasive detection module is disposed on the device body.

[0052] As an optional implementation, the main body of the device includes a control module and a display module electrically coupled to the control module, and the non-invasive detection module is electrically coupled to the control module;

[0053] When the non-invasive detection module includes multiple optical receivers, the main body of the device has a first detection mode and a second detection mode.

[0054] In the first detection mode, the control module selects the target signal from the Raman scattering signals output by multiple optical receivers, calculates and outputs the calculated value, so that the display module displays the detection result of the target signal;

[0055] In the second detection mode, the control module superimposes and calculates the Raman scattering signals output by multiple optical receivers and outputs the superimposed calculation value so that the display module displays the superimposed detection result;

[0056] The target signal is one or more of the strongest signals among the Raman scattering signals.

[0057] As an alternative implementation, the smart device includes a wearable device.

[0058] Thirdly, embodiments of this application also disclose a non-invasive detection method, the non-invasive detection method comprising:

[0059] Acquire multiple Raman scattering signals;

[0060] Determine the intensity differences among the multiple Raman scattering signals;

[0061] If the intensity differences of multiple Raman scattering signals do not meet the target conditions, the Raman scattering signals are calculated using the first detection mode;

[0062] If the intensity differences of multiple Raman scattering signals meet the target condition, the Raman scattering signals are calculated using the second detection mode;

[0063] The first detection mode is a mode in which the target signal is selected from the Raman scattering signals output by multiple optical receivers for calculation, and the second detection mode is a mode in which the Raman scattering signals output by multiple optical receivers are superimposed for calculation.

[0064] Compared with the prior art, the beneficial effects of this application are:

[0065] The non-invasive detection module provided in this application embodiment involves focusing light waves emitted by a light emitter onto the test site under the skin of the human body by a first nanounit to excite Raman scattering signals. A second nanounit collects the Raman scattering signals and transmits them to a light receiver, which then obtains the Raman spectrum of the test site to complete the non-invasive detection. Because the first and second nanounits are nanoscale structures, their sizes can be made relatively small, resulting in a smaller non-invasive detection module compared to Raman spectroscopy devices in related technologies. This allows for the integration of the non-invasive detection module into end products, better meeting daily testing needs and making non-invasive detection more convenient and faster. Attached Figure Description

[0066] To more clearly illustrate the technical solutions in the embodiments of this application, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0067] Figure 1 This is a schematic diagram of the first structure of the non-invasive detection module disclosed in the embodiments of this application;

[0068] Figure 2 yes Figure 1 The non-invasive detection module in the image is shown from a first-person perspective.

[0069] Figure 3 yes Figure 1 A schematic diagram of the optical path of the non-invasive detection module;

[0070] Figure 4 yes Figure 3 A schematic diagram of the optical path from the second perspective at point A in the middle;

[0071] Figure 5 This is a second structural schematic diagram of the non-invasive detection module disclosed in the embodiments of this application from a first perspective;

[0072] Figure 6 This is the book Figure 5 A schematic diagram of the optical path of the non-invasive detection module in the image;

[0073] Figure 7 This is a schematic diagram of the third structure of the non-invasive detection module disclosed in the embodiments of this application;

[0074] Figure 8 yes Figure 7 A schematic diagram of the optical path of the non-invasive detection module in the image;

[0075] Figure 9 yes Figure 7 The non-invasive detection module in the diagram includes an optical path diagram of the blocking part;

[0076] Figure 10 This is a schematic diagram of the structure of the smart device disclosed in the embodiments of this application;

[0077] Figure 11 This is a schematic diagram of the wearing state of the smart device disclosed in the embodiments of this application;

[0078] Figure 12 This is a schematic diagram of the first non-invasive detection method disclosed in the embodiments of this application;

[0079] Figure 13 This is a second schematic diagram of the non-invasive detection method disclosed in the embodiments of this application.

[0080] Explanation of reference numerals in the attached figures:

[0081] 100-Non-invasive detection module; 1-Light emitter; 11-Light wave; 12-Raman scattering signal; 2-First nanounit; 21-First collimator; 22-First filter; 23-First focusing part; 2a-Blocking part; 3-Second nanounit; 31-Second collimator; 32-Second filter; 33-Beam splitter; 34-Second focusing part; 35-First deflection part; 36-Reflector; 361-First sub-reflector; 362-Second sub-reflector; 37-Second deflector; 4-Light receiver; 5-Substrate assembly; 51-First substrate; 52-Second substrate; 53-Third substrate; X-First direction; Y-Second direction; Z1-Emission direction of light wave; Z2-Transmission direction of Raman scattering signal; 200-Intelligent device; 201-Main body of device; 2011-Control module; 2012-Display module; 300-Test area. Detailed Implementation

[0082] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0083] In this application, the terms "upper," "lower," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. These terms are primarily for the purpose of better describing this application and its embodiments, and are not intended to limit the indicated devices, elements, or components to having a specific orientation, or to be constructed and operated in a specific orientation.

[0084] Furthermore, in addition to indicating location or positional relationship, some of the aforementioned terms may also have other meanings. For example, the term "above" may also be used in some cases to indicate a certain dependency or connection relationship. Those skilled in the art can understand the specific meaning of these terms in this application based on the specific circumstances.

[0085] Furthermore, the terms "set up," "equipped with," and "connected" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral structure; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection via an intermediate medium, or an internal connection between two devices, components, or parts. Those skilled in the art can understand the specific meaning of these terms in this application based on the specific circumstances.

[0086] Furthermore, the terms "first," "second," etc., are primarily used to distinguish different devices, elements, or components (which may be the same or different in specific type and construction), and are not intended to indicate or imply the relative importance or quantity of the indicated devices, elements, or components. Unless otherwise stated, "a plurality of" means two or more.

[0087] Before explaining the technical solution of this application, the inventive concept of this application will be explained first.

[0088] Blood glucose monitoring is a crucial component of diabetes management. Its results help assess the degree of glucose metabolism disorder in diabetic patients, develop appropriate glucose-lowering plans, reflect the effectiveness of glucose-lowering treatment, and guide adjustments to the treatment plan. Invasive or minimally invasive blood glucose testing methods require blood sampling and are time-consuming, which can lead to patient resistance and reluctance to cooperate with regular testing. In related technologies, biofluids such as interstitial fluid, sweat, saliva, and tears are used as media for non-invasive blood glucose testing because of the correlation between glucose concentrations in these fluids and blood glucose concentrations. However, the inventors have found that these biofluids are easily affected by environmental factors (such as temperature and pH) and food intake, or are easily contaminated by other biomarkers or old sweat. Therefore, the accuracy and stability of using these fluids to detect blood glucose concentrations require further verification.

[0089] Some scholars have pointed out that light is an ideal information carrier for non-invasive detection, and that the diffraction and scattering of light are related to the molecular structure, vibration, and rotation of the medium. For example, Raman scattering is caused by the change in the frequency of light due to molecular scattering when light passes through a transparent medium. Its wavelength is determined by the chemical structure of the medium; different molecular structures can produce Raman spectra with different characteristic peaks, and the intensity of the Raman spectrum has a linear relationship with the substance content. Therefore, blood glucose detection based on Raman spectroscopy can avoid the influence of environmental media and may achieve relatively accurate and stable non-invasive blood glucose detection. Thus, the inventors attempted to use a Raman scattering spectroscopy system in non-invasive blood glucose detection devices, constructing a Raman scattering spectroscopy system using plano-convex aspherical lenses, narrow-bandpass filters, and dichroic mirrors for non-invasive blood glucose detection. Although this implementation method can achieve non-invasive detection using a Raman system, the inventors found that the detection devices required for Raman scattering spectroscopy systems are relatively large, even requiring large instruments, and the operation is cumbersome and requires a high level of expertise, making it difficult to meet the needs of convenient and quick daily testing.

[0090] In view of this, the present application provides a non-invasive detection module. By setting the first nanounit and the second nanounit as nanoscale structures, the module is smaller in size than Raman spectroscopy equipment in related technologies. This enables the integration of the non-invasive detection module into the end product, which is beneficial to meeting daily testing needs and making non-invasive detection more convenient and faster.

[0091] The technical solution of this application will be further described below with reference to specific embodiments and accompanying drawings.

[0092] Please see Figures 1 to 3 , Figure 1 This is a schematic diagram of the first structure of the non-invasive detection module disclosed in the embodiments of this application. Figure 2 yes Figure 1 The non-invasive detection module in the image is shown in the front view from a first-person perspective. Figure 3 yes Figure 1 A schematic diagram of the optical path of a non-invasive detection module is provided. In a first aspect, embodiments of this application disclose a non-invasive detection module 100, which includes a light emitter 1, a first nanounit 2, a second nanounit 3, and a light receiver 4. The first nanounit 2 is located at the light-emitting end of the light emitter 1 and is configured to focus the light wave 11 emitted by the light emitter 1 onto the test site 300 to excite a Raman scattering signal 12. The second nanounit 3 is configured to collect the Raman scattering signal 12. The light receiver 4 is configured to receive the Raman scattering signal 12 collected by the second nanounit 3 to obtain the Raman spectrum of the human body test site 300.

[0093] The non-invasive detection module disclosed in this application, through the cooperation of the first nanounit 2 and the second nanounit 3, on the one hand, realizes the transmission process of the light wave 11 of the Raman detection system; on the other hand, since the first nanounit 2 and the second nanounit 3 are nanoscale structures, their sizes can be made smaller, making the size of the non-invasive detection module 100 smaller than that of Raman spectroscopy equipment in related technologies. This allows the non-invasive detection module 100 to be integrated into end products, thereby meeting daily detection needs, facilitating non-invasive detection, and making detection more convenient and faster.

[0094] It is understood that the test site 300 is determined according to the specific test item, and this embodiment does not limit it. For example, when performing blood glucose testing, the test site 300 may include blood vessels less than 1 mm below the skin.

[0095] It is understandable that the first nanounit 2 and the second nanounit 3 are achieved by using isotropic or anisotropic nanostructures, combined with the design degrees of freedom such as the orientation angle and displacement of the nanostructures, thereby realizing the control of the amplitude, phase, polarization, frequency and spectrum of light wave 11 at the nanoscale.

[0096] Optionally, the aforementioned light emitter 1 may include a vertical cavity surface emitting laser (VCSEL), a semiconductor laser diode (LD), etc., and this embodiment does not limit it.

[0097] Optionally, the center wavelength of the light wave 11 emitted by the aforementioned light emitter 1 is 500nm to 1800nm. By setting the light wave 11 to emit a wide range of center wavelengths, different center wavelengths of light wave 11 can be selected for Raman detection during use, allowing the non-invasive detection module 100 to adapt to different detection needs. For example, selecting a light wave 11 with a center wavelength of 532nm can further improve the signal-to-noise ratio of the non-invasive detection module 100, which is beneficial to improving the analysis speed and accuracy of the non-invasive detection module 100; in addition, selecting a light wave 11 with a center wavelength of 785nm can make the performance of the non-invasive detection module 100 more balanced, with a faster analysis speed and a certain fluorescence self-suppression capability, and lower operating costs; or, selecting a light wave 11 with a center wavelength of 1064nm can better reduce the fluorescence background of the human body to be tested, which is beneficial to reducing background interference and further improving the detection accuracy of the non-invasive detection module 100.

[0098] Optionally, the light wave 11 emitted by the light emitter 1 can be a continuous light wave or a pulsed light wave 11, and this embodiment does not limit this. For example, the light wave 11 emitted by the light emitter 1 is a pulsed light wave 11, which can further improve the signal-to-noise ratio of the non-invasive detection module 100 or enable it to process specific sample types.

[0099] Optionally, the spectral width of the light wave 11 emitted by the light emitter 1 is 0.1nm to 50nm, for example, 0.1nm, 0.5nm, 1nm, 2nm, 5nm, 10nm, 20nm, 40nm, 50nm, etc.

[0100] That is, optionally, the spectral width of the light wave 11 emitted by the light emitter 1 can be 0.1nm-50nm, or the spectral width of the light wave 11 emitted by the light emitter 1 can be 0.1nm-40nm, or the spectral width of the light wave 11 emitted by the light emitter 1 can be 0.1nm-20nm, or the spectral width of the light wave 11 emitted by the light emitter 1 can be 0.1nm-10nm, or the spectral width of the light wave 11 emitted by the light emitter 1 can be 0.5nm-10nm, or the spectral width of the light wave 11 emitted by the light emitter 1 can be 1nm-10nm, and so on.

[0101] This spectral width range allows the light wave 11 of the light emitter 1 to better match the Raman frequency shift of the sample, which is beneficial to improving the intensity and resolution of the Raman signal; in addition, it can reduce background interference and improve the signal-to-noise ratio, which is beneficial to further improve the accuracy and reliability of the non-invasive detection module 100.

[0102] In some embodiments, such as Figure 2 and Figure 3 As shown, the first nanounit 2 may include a first collimation section 21, which is disposed along the light-emitting end of the light emitter 1 and is configured to collimate the light wave 11.

[0103] Optionally, the first nanounit may include a first filter section 22, which is disposed along the light emission end of the light emitter 1 along the light emission direction Z1 of the light wave, and the first filter section 22 is configured to filter the light wave 11.

[0104] Optionally, the first nanounit may include a first focusing section disposed along the light-emitting end of the light emitter 1. The first focusing section 23 is configured to focus the light wave 11 onto the test site 300 to excite the Raman scattering signal 12.

[0105] By employing a nanostructured first collimator 21, first filter 22, and first focusing part 23, compared to traditional optical elements (such as lenses, filters, and diffraction gratings), the barrier of long optical paths in traditional optical elements can be overcome, allowing the distance between the first collimator 21, first filter 22, and first focusing part 23 to be set smaller, which is beneficial for the miniaturization and integration design of the non-invasive detection module 100.

[0106] Specifically, the first collimation section 21 collimates the light wave 11 emitted by the light emitter 1 into the first parallel light, and then the first filtering section 22 performs ultra-narrow bandpass filtering on the first parallel light so that the center wavelength of the first parallel light passing through the first filtering section 22 is the same as the center wavelength of the light wave 11 emitted by the light emitter 1; finally, the first focusing section 23 focuses the filtered first parallel light onto the test site 300 under the human skin, thereby realizing the excitation of the Raman scattering signal 12.

[0107] Understandably, the first collimating section 21 is constructed as a nanostructure capable of phase adjustment of the light wave 11 at the microscopic level, thereby achieving the collimation function. The first filtering section 22 is constructed as a nanostructure capable of allowing light signals of a specific wavelength to pass through while reflecting or absorbing light signals of other wavelengths, thereby achieving the bandpass filtering function. Similarly, the first focusing section 23 is constructed as a nanostructure with an optical resonance effect, capable of focusing the light wave 11 onto the measurement area 300 by adjusting the phase delay of different regions, thereby achieving the focusing function.

[0108] In some optional embodiments, the first focusing part 23 and the first filtering part 22 are spaced apart along the light wave emission direction Z1, and the first collimating part 21 and the first filtering part 22 are integrally disposed. This approach reduces the distance between the first collimating part 21 and the first filtering part 22 along the light wave emission direction Z1, further reducing the thickness of the non-invasive detection module 100 along the light wave emission direction Z1, which is beneficial for the miniaturization and integration design of the non-invasive detection module 100.

[0109] Optionally, the first collimating section 21 and the first filtering section 22 are integrally formed, or they can be integrally molded into a single nanostructure. This nanostructure is configured to adjust the phase of the light wave 11, transmit light signals of a specific wavelength, and reflect or absorb light signals of other wavelengths. This further reduces the thickness of the non-invasive detection module 100 in the light wave emission direction Z1, which is beneficial for the miniaturization and integration of the non-invasive detection module 100.

[0110] Alternatively, the first collimator 21 and the first filter 22 can be integrally formed, or the first collimator 21 and the first filter 22 can be two nanostructures stacked together. In this way, the first collimator 21 and the first filter 22 can be individually controlled in their optical paths, which is beneficial for achieving better optical results.

[0111] Other alternative implementations, such as Figure 2 and Figure 3 As shown, along the light wave emission direction Z1, the first focusing part 23 and the first filtering part 22 are spaced apart, and the first collimating part 21 and the first filtering part 22 are also spaced apart. Thus, along the light wave emission direction Z1, the first filtering part 22 is located between the first collimating part 21 and the first focusing part 23. By separating optical components with different functions, the mutual influence between the first collimating part 21, the first filtering part 22, and the first focusing part 23 can be reduced, improving the optical performance and stability of the non-invasive detection module 100. Furthermore, the spaced arrangement of the first collimating part 21 and the first filtering part 22 allows for more precise parameter settings for each through individual structural design, enabling more accurate control of the light path and achieving better optical effects.

[0112] Please combine Figure 4 , Figure 4 yes Figure 3 The diagram shows the optical path at point A from a second perspective. In some embodiments, the second nanounit 3 may include a second collimator 31, which is disposed upstream of the photoreceiver 4 along the transmission direction Z2 of the Raman scattering signal, and is configured to collimate the Raman scattering signal 12.

[0113] Optionally, the second nanounit 3 may include a second filter section 32, which is disposed upstream of the photoreceiver 4 along the transmission direction Z2 of the Raman scattering signal, and is configured to filter the Raman scattering signal 12.

[0114] Optionally, the second nanounit 3 may include a beam splitter 33, which is disposed upstream of the photoreceiver 4 along the transmission direction Z2 of the Raman scattering signal. The beam splitter 33 is configured to separate signals of different wavelengths in the Raman scattering signal 12 along a first direction X, wherein the first direction X is the direction intersecting with the direction Z2 of the Raman scattering signal 12.

[0115] Optionally, the second nanounit 3 may include a second focusing part 34, which is disposed upstream of the photoreceiver 4 along the transmission direction Z2 of the Raman scattering signal. The second focusing part 34 is configured to focus a signal of the same wavelength onto the photoreceiver 4.

[0116] The second collimating part 31, the second filtering part 32, the beam splitting part 33, and the second focusing part 34 of the nanostructure can also break through the barrier of long optical paths in traditional optical elements, so that the distance between the second collimating part 31, the second filtering part 32, the beam splitting part 33, and the second focusing part 34 can be set to be smaller, thereby making the Raman scattering signal 12 collection system smaller, which is conducive to the miniaturization and integration of the non-invasive detection module 100.

[0117] Specifically, the second collimation section 31 collimates the Raman scattering signal 12 excited by the light wave 11 into a second parallel light; then, the second filtering section 32 filters out the signal light in the second parallel light that has the same wavelength as the light wave 11 emitted by the light emitter 1; then, the beam splitting section 33 separates the signal light of different wavelengths in the filtered second parallel light along the first direction X; finally, the second focusing section 34 focuses the separated signal light onto the light receiver 4 according to wavelength, so as to realize the collection and transmission of the Raman scattering signal 12.

[0118] Understandably, the second collimator 31 is constructed as a nanostructure capable of phase adjustment of the light wave 11 at the microscopic level, thereby achieving the collimation function. The second filter 32 is constructed with special reflection or transmission properties, enabling the suppression or reflection of light signals within a specific wavelength range, thereby achieving the band-stop filtering function. The beam splitter 33 is constructed as a nanostructure with a grating or diffraction structure, capable of separating the incident light according to different wavelengths, thereby achieving the beam splitting function. Similarly, the second focusing part 34 is constructed as a nanostructure with an optical resonance effect, capable of focusing the light wave 11 onto the measurement area 300 by adjusting the phase delay of different regions, thereby achieving the focusing function.

[0119] Optionally, the above-mentioned process of collecting and transmitting the Raman scattering signal 12 can also be as follows: the Raman scattering signal 12 excited by the light wave 11 is collimated into a second parallel light by the second collimation section 31; then, the signal light of different wavelengths in the filtered second parallel light is separated along the first direction X by the beam splitter 33; then, the signal light with the same wavelength as the light wave 11 emitted by the light emitter 1 is filtered out by the second filter section 32; finally, the separated signal light is focused onto the light receiver 4 by the second focusing section 34 according to wavelength, so as to realize the collection and transmission of the Raman scattering signal 12.

[0120] In some optional embodiments, along the transmission direction Z2 of the Raman scattering signal, the second focusing part 34 and the beam splitting part 33 are arranged at intervals, and at least two of the second collimating part 31, the second filtering part 32, and the beam splitting part 33 are integrally arranged. That is, the second collimating part 31 and the second filtering part 32 can be integrally arranged, and the beam splitting part 33 can be arranged at intervals with the second filtering part 32; the second collimating part 31 and the second filtering part 32 can be arranged at intervals, and the second filtering part 32 and the beam splitting part 33 can be integrally arranged; the second collimating part 31 and the beam splitting part 33 can be integrally arranged, and the second filtering part 32 and the beam splitting part 33 can be arranged at intervals; or, the second collimating part 31, the second filtering part 32, and the beam splitting part 33 can be integrally arranged. This embodiment does not limit this.

[0121] By integrating the components, the spacing between the second collimator 31, the second filter 32, and the beam splitter 33 along the Raman scattering signal transmission direction Z2 can be reduced, thereby reducing the thickness of the non-invasive detection module 100 along the Raman scattering signal transmission direction Z2, which is beneficial for the miniaturization and integration of the non-invasive detection module 100.

[0122] It is understandable that the propagation direction Z2 of the Raman scattering signal is opposite to the emission direction Z1 of the light wave. For example, as... Figure 3 As shown, the emission direction Z1 of the light wave is downward along the paper, while the transmission direction Z2 of the Raman scattering signal is upward along the paper.

[0123] It is understood that at least two of the aforementioned second collimation section 31, second filter section 32, and beam splitter 33 may be integrally formed into a single nanostructure, which is configured to have the functions of at least two of the components in the second collimation section 31, second filter section 32, and beam splitter 33; or at least two of the nanostructures in the second collimation section 31, second filter section 32, and beam splitter 33 may be stacked together. This embodiment does not limit this.

[0124] In other alternative embodiments, the second collimator 31, the second filter 32, the beam splitter 33, and the second focusing unit 34 are arranged sequentially at intervals along the transmission direction Z2 of the Raman scattering signal. By separating optical components with different functions, the mutual influence between the second collimator 31, the second filter 32, the beam splitter 33, and the second focusing unit 34 can be reduced, improving the optical performance and stability of the non-invasive detection module 100. Furthermore, in this way, the second collimator 31, the second filter 32, the beam splitter 33, and the second focusing unit 34 can each individually control the Raman scattering signal 12, resulting in better control. At the same time, this method uses a separate structural design, which allows for more precise parameter settings for the second collimator 31, the second filter 32, the beam splitter 33, and the second focusing unit 34, enabling the first collimator 21 and the first filter 22 to more precisely control the optical path and achieve better optical effects.

[0125] Considering that the optical transmitter and optical receiver can be integrated or separate, based on this, in some embodiments, such as Figure 2 and Figure 3 As shown, the non-invasive detection module 100 also includes a substrate assembly 5, which includes a first substrate 51. A light emitter 1 and a light receiver 4 are spaced apart on the first substrate 51, and a first nanounit 2 and a second nanounit 3 are at least partially disposed on the first substrate 51. The first substrate 51 serves two purposes: firstly, it supports the light emitter 1, the first nanounit 2, the second nanounit 3, and the light receiver 4; secondly, it enables the integrated modularization of the light emitter 1, the first nanounit 2, the second nanounit 3, and the light receiver 4, thereby improving the structural compactness of the non-invasive detection module 100 and facilitating its miniaturization design.

[0126] It is understandable that when the light emitter 1 and the light receiver 4 are both disposed on the first substrate 51, there should be a sufficient gap between the light receiver 4 and the light emitter 1 to avoid light crosstalk between the light emitter 1 and the light receiver 4.

[0127] Of course, as another example, a blocking portion may also be provided on the first substrate 51, and the blocking portion may be located between the light emitter 1 and the light receiver 4, thereby blocking light from passing between the light emitter 1 and the light receiver 4. Exemplarily, the blocking portion may include, but is not limited to, a baffle, a barrier, or a curtain.

[0128] Optionally, when the first nanounit 2 is at least partially disposed on the first substrate 51, it may be: the first collimation portion 21 is disposed on the first substrate 51, or the first filtering portion 22 is disposed on the first substrate 51, or the first focusing portion 23 is disposed on the first substrate 51, or the first collimation portion 21 and the first filtering portion 22 are disposed on the first substrate 51, or the first collimation portion 21 and the first focusing portion 23 are disposed on the first substrate 51, or the first filtering portion 22 and the first focusing portion 23 are disposed on the first substrate 51, or the first collimation portion 21, the first filtering portion 22 and the first focusing portion 23 are disposed on the first substrate 51, or the first collimation portion 21, the first filtering portion 22 and the first focusing portion 23 are disposed on the first substrate 51.

[0129] Optionally, when the second nanounit 3 is at least partially disposed on the first substrate 51, it can be: the second focusing portion 34 is disposed on the first substrate 51; or, the beam-splitting portion 33 is disposed on the first substrate 51; or, the second filtering portion 32 is disposed on the first substrate 51; or, the second collimating portion 31 is disposed on the first substrate 51; or, the second focusing portion 34 and the beam-splitting portion 33 are disposed on the first substrate 51; or, the second focusing portion 34 and the second filtering portion 32 are disposed on the first substrate 51; or, the second focusing portion 34 and the second collimating portion 31 are disposed on the first substrate 51; or, the beam-splitting portion 33 and the second filtering portion 32 are disposed on the first substrate 511; or, the beam-splitting portion 33 and the second filtering portion 32 are disposed on the first substrate 511; or, the beam-splitting portion 33 and the second filtering portion 32 are disposed on the first substrate 511. The second collimating part 31 is disposed on the first substrate 51, or the second filtering part 32 and the second collimating part 31 are disposed on the first substrate 51, or the second focusing part 34, the beam splitting part 33 and the second filtering part 32 are disposed on the first substrate 51, or the second focusing part 34, the beam splitting part 33 and the second collimating part 31 are disposed on the first substrate 51, or the second focusing part 34, the second filtering part 32 and the second collimating part 31 are disposed on the first substrate 51, or the beam splitting part 33, the second filtering part 32 and the second collimating part 31 are disposed on the first substrate 51, or the second focusing part 34, the beam splitting part 33, the second filtering part 32 and the second collimating part 31 are disposed on the first substrate 51.

[0130] Please see Figure 5 and Figure 6 , Figure 5 This is a second structural schematic diagram of the non-invasive detection module disclosed in the embodiments of this application from a first perspective; Figure 6 This is the book Figure 5The diagram shows the optical path of the non-invasive detection module. Optionally, the substrate assembly 5 further includes a second substrate 52, which is located at the light-emitting end of the light emitter 1 and is spaced apart from the first substrate 51. By including the first substrate and the second substrate in the substrate assembly 5, mounting positions can be provided for the first collimating section 21, the first filtering section 22, the first focusing section 23, the second collimating section 31, the second filtering section 32, the beam splitting section 33, and the second focusing section 34, making the structure of the non-invasive detection module 100 simpler. Furthermore, the distance between the second substrate 52 and the first substrate 51 can provide space for the formation of an optical path between the first collimating section 21, the first filtering section 22, and the first focusing section 23; similarly, it can also provide space for the formation of an optical path between the second collimating section 31, the second filtering section 32, the beam splitting section 33, and the second focusing section 34.

[0131] As can be seen from the foregoing, the first nanounit 2 may include a first collimation part 21 disposed along the emission direction Z1 of the light wave. The first collimation part 21 is disposed on the first substrate 51 and is disposed corresponding to the light emitter 1. The first collimation part 21 is configured to collimate the light wave 11.

[0132] Optionally, the first nanounit 2 may include a first filter section 22 disposed along the emission direction Z1 of the light wave. The first filter section 22 is disposed on the first substrate 51 and is disposed corresponding to the light emitter 1. The first filter section 22 is configured to filter the light wave 11.

[0133] Optionally, the first nanounit 2 may include a first focusing part 23 disposed along the emission direction Z1 of the light wave. The first focusing part 23 is disposed on the second substrate 52 and is disposed corresponding to the light emitter 1. The first focusing part 23 is configured to focus the light wave 11 onto the test area 300 to excite the Raman scattering signal 12.

[0134] Optionally, the second nanounit 3 may include a second focusing portion 34 disposed along the transmission direction Z2 of the Raman scattering signal. The second focusing portion 34 is disposed on the second substrate 52 and is disposed corresponding to the light receiver 4. The second focusing portion 34 is disposed at a distance from the first focusing portion 23. The second focusing portion 34 is configured to focus signals of the same wavelength onto the light receiver 4.

[0135] Optionally, the second nanounit 3 may include a second collimation portion 31 disposed along the transmission direction Z2 of the Raman scattering signal. The second collimation portion 31 is disposed on the second substrate 52 and located between the second focusing portion 34 and the first focusing portion 23. The second collimation portion 31 is configured to collimate the Raman scattering signal 12.

[0136] Optionally, the second nanounit 3 may include a second filter section 32 disposed along the transmission direction Z2 of the Raman scattering signal. The second filter section 32 is disposed on the second substrate 52 and located between the second focusing section 34 and the first focusing section 23. The second filter section 32 is configured to filter the Raman scattering signal 12.

[0137] Optionally, the second nanounit 3 may include a beam splitter 33 disposed along the transmission direction Z2 of the Raman scattering signal. The beam splitter 33 is disposed on the second substrate 52 and located between the second focusing part 34 and the first focusing part 23. The beam splitter 33 is configured to separate signals of different wavelengths in the Raman scattering signal 12 along a first direction X, wherein the first direction X is the direction intersecting with the transmission direction Z2 of the Raman scattering signal.

[0138] The non-invasive detection module 100 provided in this application achieves fixed connection of components in the first nanounit 2 and the second nanounit 3 through the first substrate 51 and the second substrate 52; and, through the first substrate 51, the first collimation part 21, the first filter part 22, the light emitter 1 and the light receiver 4 are integrated together, and through the second substrate 52, the second focusing part 34, the second collimation part 31, the second filter part 32, the beam splitter 33 and the second focusing part 34 are integrated together, which is beneficial to improving the structural compactness of the non-invasive detection module 100, and thus beneficial to the integrated modularization of the non-invasive detection module 100.

[0139] That is, when the substrate assembly 5 includes a first substrate 51 and a second substrate 52, the first nanounit 2 and the second nanounit 3 can be set using the first substrate 51 and the second substrate 52 to achieve the integrated design of the non-invasive detection module 100. Furthermore, by setting the first focusing part 23 on the second substrate 52, the distance between the first focusing part 23 and the first filtering part 22 can be controlled using the second substrate 52, thereby achieving adjustable transmission path length for the light wave 11.

[0140] Optionally, the first collimating section 21 and the first filtering section 22 are integrally disposed; additionally, at least two of the second collimating section 31, the second filtering section 32, and the beam splitter 33 are integrally disposed; or, the first collimating section 21 and the first filtering section 22 are integrally disposed, and at least two of the second collimating section 31, the second filtering section 32, and the beam splitter 33 are integrally disposed. By integrally disposing the first collimating section 21 and the first filtering section 22 on the first substrate 51, without the need for a separate additional structure to fix the first filtering section 22, the structure of the first nanounit 2 can be made more compact, which is beneficial to reducing the size of the first nanounit 2 along the light emission direction Z1. Similarly, by integrally disposing at least two of the second collimating section 31, the second filtering section 32, and the beam splitter 33, the structure of the second nanounit 3 can also be made more compact, which is beneficial to reducing the size of the second nanounit 3 along the Raman scattering signal transmission direction Z2. By integrating the first collimating section 21 and the first filtering section 22, and by integrating at least two of the second collimating section 31, the second filtering section 32, and the beam splitter 33, the dimensions of the first nanounit 2 and the second nanounit 3 along the light emission direction Z1 can be reduced simultaneously. This facilitates the integration and miniaturization of the non-invasive detection module 100, thereby enabling its integration into end products. For example, as shown... Figure 5 and Figure 6 As shown, the first collimation section 21 and the first filter section 22 are integrally arranged, and at least two of the second collimation section 31, the second filter section 32, and the beam splitter 33 are integrally arranged.

[0141] It is understood that at least two of the aforementioned second collimation section 31, second filter section 32, and beam splitter 33 may be integrally arranged. This could mean that the second collimation section 31 and second filter section 32 are integrally arranged, with the beam splitter 33 spaced apart from the second filter section 32; or that the second collimation section 31 and second filter section 32 are spaced apart, while the second filter section 32 and beam splitter 33 are integrally arranged; or that the second collimation section 31 and beam splitter 33 are integrally arranged, with the second filter section 32 spaced apart from the beam splitter 33; or that all three—the second collimation section 31, second filter section 32, and beam splitter 33—are integrally arranged. This embodiment does not limit this arrangement.

[0142] It is understood that at least two of the aforementioned second collimation section 31, second filter section 32, and beam splitter 33 may be integrally formed into a single nanostructure, which is configured to have the functions of at least two of the components in the second collimation section 31, second filter section 32, and beam splitter 33; or at least two of the nanostructures in the second collimation section 31, second filter section 32, and beam splitter 33 may be stacked together. This embodiment does not limit this.

[0143] As an optional implementation method, such as Figure 5 andFigure 6 As shown, the second nanounit 3 may also include a first deflection portion 35, which is disposed on the first substrate 51 and corresponding to the second collimation portion 31. The first deflection portion 35 is located between the first collimation portion 21 and the light receiver 4. The first deflection portion 35 is configured to deflect the Raman scattering signal 12 by a deflection angle.

[0144] Optionally, the second nanounit 3 may also include a reflective portion 36, which may include a first sub-reflective portion 361. The first sub-reflective portion 361 is disposed on the second substrate 52 and is located between the beam splitter 33 and the second focusing portion 34. The first sub-reflective portion 361 is configured to reflect the Raman scattering signal 12.

[0145] Optionally, the reflective portion may include a second sub-reflective portion 362, which is disposed on the first substrate 51 and located between the first deflection portion 35 and the light receiver 4. The second sub-reflective portion 362 is configured to reflect the Raman scattering signal 12.

[0146] Optionally, the second nanounit 3 may include a second deflection section 37, which is disposed on the second substrate 52 corresponding to the light receiver 4, and is disposed upstream of the second focusing section 34 along the transmission direction Z2 of the Raman scattering signal. The second deflection section 37 is configured to reflect the Raman scattering signal 12 to the second focusing section 34 by a deflection angle.

[0147] By employing a first deflection section 35, a first sub-reflection section 361, a second sub-reflection section 362, and a second deflection section 37 to reflect the Raman scattering signal 12, on the one hand, the Raman scattering signal 12 is transmitted from the beam splitter 33 to the second focusing section 34; on the other hand, since the Raman scattering signal 12 obtains different deflection angles after being split by the beam splitter 33, the reflection of the Raman scattering signal 12 by the first deflection section 35, the first sub-reflection section 361, the second sub-reflection section 362, and the second deflection section 37 extends the transmission path of the Raman scattering signal 12, which is beneficial to increasing the separation distance of signal light of different wavelengths, and thus is beneficial to obtaining higher spectral resolution.

[0148] Specifically, the Raman scattering signal 12 is split by the beam splitter 33 and then transmitted to the first deflector 35. The first deflector 35 deflects the Raman scattering signal 12 by an angle and reflects it to the first sub-reflector 361. The first sub-reflector 361 reflects it to the second sub-reflector 362. The second sub-reflector 362 then deflects the Raman scattering signal 12 by an angle and reflects it to the second focusing part 34. The second focusing part 34 focuses the Raman scattering signal 12 onto the light receiver 4, thereby realizing the reception of the Raman scattering signal 12.

[0149] Understandably, both the first deflection section 35 and the second deflection section 37 are constructed as nanostructures with phase delay, capable of deflecting or modulating the optical signal, thereby achieving reflection and deflection of the Raman scattering signal 12. Similarly, both the first sub-reflection section 361 and the second sub-reflection section 362 are constructed as nanostructures with high reflectivity, capable of reflecting the incident signal light at the same incident angle.

[0150] Optionally, such as Figure 5 and Figure 6 As shown, the second deflection part 37 and the second focusing part 34 are integrally formed. This integral formation achieves a fixed connection between the second deflection part 37 and the second focusing part 34, eliminating the need for additional components to connect them. Furthermore, by integrating the second deflection part 37 and the second focusing part 34, the spacing between them is reduced, which helps to decrease the size of the second nanounit along the Raman scattering signal transmission direction Z2, thus facilitating the integration of the non-invasive detection module 100.

[0151] It is understood that the second deflection part 37 and the second focusing part 34 are integrally formed, which can be a single nanostructure with phase delay and optical resonance effect. This nanostructure can reflect and deflect the light signal, and can focus the light wave 11 onto the test part 300 by adjusting the phase delay of different regions, thereby realizing the reflection deflection and focusing functions. Alternatively, the two nanostructures, the second deflection part 37 and the second focusing part 34, can be superimposed. This embodiment does not limit this.

[0152] Optionally, the second deflection portion 37 and the second focusing portion 34 are spaced apart. This spaced arrangement allows the second deflection portion 37 and the second focusing portion 34 to be separate nanostructures, enabling them to independently control the signal light and reducing their mutual interference. This results in better detection performance of the non-invasive detection module 100, improving its signal-to-noise ratio and stability. Furthermore, more precise parameter settings can be applied to each nanostructure, leading to superior optical performance for the second deflection portion 37 and the second focusing portion 34.

[0153] As an optional implementation, the reflective portion 36 includes multiple sets, which are sequentially disposed between the first deflecting portion 35 and the second deflecting portion 37 along the second direction Y, where the second direction Y is the direction from the light emitter 1 to the light receiver 4. The multiple sets of reflective portions 36 further extend the transmission path of the Raman scattering signal 12, thereby increasing the separation distance between signal light of different wavelengths, which is beneficial for further improving the spectral resolution and thus improving the detection accuracy of the non-invasive detection module 100.

[0154] For example, the reflective portion 36 includes two sets, each set of which includes a first sub-reflective portion 361 and a second sub-reflective portion 362. The two first sub-reflective portions 361 are both disposed on the second substrate 52, and are sequentially disposed between the beam splitter 33 and the second focusing portion 34 along the second direction Y. The two second sub-reflective portions 362 are both disposed on the first substrate 51, and are sequentially disposed between the first deflector 35 and the light receiver 4 along the second direction Y.

[0155] Please see Figures 7 to 9 , Figure 7 This is a schematic diagram of the third structure of the non-invasive detection module disclosed in the embodiments of this application; Figure 8 yes Figure 7 A schematic diagram of the optical path of the non-invasive detection module in the image; Figure 9 yes Figure 7 The non-invasive detection module includes a schematic diagram of the optical path of the blocking part. Optionally, the substrate assembly 5 may include a second substrate 52 and a third substrate 53 in addition to the first substrate mentioned above. The second substrate 52 and the third substrate 53 are located at the light-emitting end of the light emitter 1, and the first substrate 51, the second substrate 52, and the third substrate 53 are arranged sequentially along the light wave emission direction Z1.

[0156] As can be seen from the foregoing, the first nanounit 2 may include a first collimation part 21 disposed along the emission direction Z1 of the light wave. The first collimation part 21 is disposed on the first substrate 51 corresponding to the light emitter 1, and the first collimation part 21 is configured to collimate the light wave 11.

[0157] Optionally, the first nanounit 2 may include a first filter section 22 disposed along the emission direction Z1 of the light wave. The first filter section 22 is disposed on the second substrate 52 corresponding to the light emitter 1, and the first filter section 22 is configured to filter the light wave 11.

[0158] Optionally, the first nanounit 2 may include a first focusing part 23 disposed along the emission direction Z1 of the light wave. The first focusing part 23 is disposed on the third substrate 53 corresponding to the first filtering part 22. The first focusing part 23 is configured to focus the filtered light wave 11 onto the test area 300 to excite the Raman scattering signal 12.

[0159] Optionally, the second nanounit 3 may include a second collimation section 31 disposed along the transmission direction Z2 of the Raman scattering signal. The second collimation section 31 is disposed on the third substrate 53 corresponding to the light receiver 4, and the second collimation section 31 is disposed at a distance from the first focusing section 23. The second collimation section 31 is configured to collimate the Raman scattering signal 12.

[0160] Optionally, the second nanounit 3 may include a second filter section 32 disposed along the transmission direction Z2 of the Raman scattering signal. The second filter section 32 is disposed on the third substrate 53 corresponding to the photoreceiver 4 and is disposed at an interval from the first focusing section 23. The second filter section 32 is configured to filter the Raman scattering signal 12.

[0161] Optionally, the second nanounit 3 may include a beam splitter 33 disposed along the transmission direction Z2 of the Raman scattering signal. The beam splitter 33 is disposed on the third substrate 53 corresponding to the light receiver 4, and the beam splitter 33 is disposed at a distance from the first focusing part 23. The beam splitter 33 is configured to separate signals of different wavelengths in the Raman scattering signal 12 along a first direction X, wherein the first direction X is the direction intersecting with the direction Z2 of the Raman scattering signal 12.

[0162] Optionally, the second nanounit 3 may include a second focusing part 34 disposed along the transmission direction Z2 of the Raman scattering signal. The second focusing part 34 is disposed on the second substrate 52 corresponding to the beam splitter 33, and the second focusing part 34 is disposed at a distance from the first filter part 22. The second focusing part 34 is configured to focus signals of the same wavelength onto the photoreceiver 4.

[0163] The non-invasive detection module 100 provided in this application achieves fixed connection of components in the first nanounit 2 and the second nanounit 3 through the first substrate 51, the second substrate 52, and the third substrate 53. Furthermore, the first substrate 51 integrates the light emitter 1, the light receiver 4, and the first collimator 21; the second substrate 52 integrates the first filter 22 and the second focusing part 34; and the third substrate 53 integrates the first focusing part 23, the second collimator 31, the second filter 32, and the beam splitter 33. This improves the structural compactness of the non-invasive detection module 100, thereby facilitating its modular integration. In addition, the use of the first substrate 51, the second substrate 52, and the third substrate 53 eliminates the need for additional first deflection part 35, reflection part 36, and second deflection part 37 to transmit the Raman scattering signal 12 between the beam splitter 33 and the second focusing part 34. This reduces the size of the non-invasive detection module 100 in the second direction Y, further facilitating its modular integration.

[0164] As an optional implementation, at least two of the second collimating section 31, the second filtering section 32, and the beam splitter 33 are integrally arranged. It is understood that the second collimating section 31 and the second filtering section 32 may be integrally arranged, with the beam splitter 33 spaced apart from the second filtering section 32; the second collimating section 31 and the second filtering section 32 may be spaced apart, while the second filtering section 32 and the beam splitter 33 may be integrally arranged; the second collimating section 31 and the beam splitter 33 may be integrally arranged, with the second filtering section 32 spaced apart from the beam splitter 33; or, the second collimating section 31, the second filtering section 32, and the beam splitter 33 may all be integrally arranged. This embodiment does not limit this to any particular configuration. For example, as shown... Figure 8 and Figure 9 As shown, the second collimating section 31, the second filtering section 32, and the beam splitter 33 are integrated into one unit. This allows for direct and fixed connection of the second collimating section 31, the second filtering section 32, and the beam splitter 33 without requiring additional components. Furthermore, by integrating them into one unit, the spacing between the second collimating section 31, the second filtering section 32, and the beam splitter 33 is reduced, allowing more space between the third substrate 53 and the second substrate 52 to be allocated to the second focusing section 34 and the beam splitter 33. This increases the transmission path of the Raman scattering signal 12 after beam splitting, resulting in a greater separation distance between signal lights of different wavelengths, further improving spectral resolution and the detection accuracy of the non-invasive detection module 100.

[0165] Similarly, at least two of the above-mentioned second collimation section 31, second filter section 32 and beam splitter section 33 can be integrally formed into a nanostructure, which is constructed to have the functions of at least two of the components of the second collimation section 31, second filter section 32 and beam splitter section 33; or at least two of the second collimation section 31, second filter section 32 and beam splitter section 33 can be stacked together. This embodiment does not limit this.

[0166] Optionally, the optical receiver 4 and the optical transmitter 1 are spaced apart along the second direction Y, and the distance between the optical receiver 4 and the optical transmitter 1 in the second direction Y is 200μm to 5mm. For example, 200μm, 500μm, 1mm, 2mm, 3mm, 4mm, 5mm, etc.

[0167] That is, optionally, the distance between the optical receiver 4 and the optical transmitter 1 in the second direction Y can be 500μm-5mm, or the distance between the optical receiver 4 and the optical transmitter 1 in the second direction Y can be 500μm-4mm, or the distance between the optical receiver 4 and the optical transmitter 1 in the second direction Y can be 500μm-3mm, or the distance between the optical receiver 4 and the optical transmitter 1 in the second direction Y can be 1mm-3mm, or the distance between the optical receiver 4 and the optical transmitter 1 in the second direction Y can be 2mm-3mm, etc.

[0168] In this context, the second direction Y is the direction from the light emitter 1 to the light receiver 4. By setting the intervals, mutual interference between the light receiver 4 and the light emitter 1 is avoided, thereby further improving the accuracy of the detection results from the non-invasive detection module 100.

[0169] In some alternative embodiments, the first nanounit 2 and the second nanounit 3 are spaced apart along the second direction Y, and the distance between the first nanounit 2 and the second nanounit 3 along the second direction Y is 200μm to 5mm, for example, 200μm, 500μm, 1mm, 2mm, 3mm, 4mm, 5mm, etc.

[0170] That is, optionally, the distance between the first nanounit 2 and the second nanounit 3 along the second direction Y can be 500μm-5mm, or the distance between the first nanounit 2 and the second nanounit 3 along the second direction Y can be 500μm-4mm, or the distance between the first nanounit 2 and the second nanounit 3 along the second direction Y can be 500μm-3mm, or the distance between the first nanounit 2 and the second nanounit 3 along the second direction Y can be 1mm-3mm, or the distance between the first nanounit 2 and the second nanounit 3 along the second direction Y can be 2mm-3mm, and so on.

[0171] Wherein, the second direction Y is the direction from which the light emitter 1 points to the light receiver 4. By adjusting the spacing between the first nanounit 2 and the second nanounit 3 along the second direction Y, the occurrence of light reflection from the first nanounit 2 to the second nanounit 3 can be reduced. That is, integrating the first nanounit 2 and the second nanounit 3 onto the substrate assembly 5 can also reduce the probability of interference between them, which is beneficial to reducing the detection error of the non-invasive detection module 100 and improving the detection accuracy of the non-invasive detection module 100; at the same time, it is beneficial to improve the integration and modularity of the non-invasive detection module 100.

[0172] Optionally, such as Figure 9As shown, a blocking portion 2a can be provided between the first nanounit 2 and the second nanounit 3. The blocking portion 2a is configured to prevent light from the first nanounit 2 from being reflected to the second nanounit 3, wherein the second direction Y is the direction from which the light emitter 1 points to the light receiver 4. By using the blocking portion 2a, the reflection of light from the first nanounit 2 to the second nanounit 3 can be avoided, which helps to further reduce the detection error of the non-invasive detection module 100, and thus helps to further improve the detection accuracy of the non-invasive detection module 100.

[0173] Optionally, the aforementioned blocking part 2a may include, but is not limited to, a baffle, a retaining wall, or a baffle strip.

[0174] Optionally, the material of the aforementioned blocking part 2a may include, but is not limited to, metal, plastic, glass, or cotton cloth.

[0175] It is understood that when the above-mentioned second nanounit 3 includes multiple second nanounits 3 arranged around the first nanounit 2 on the outer periphery of the first nanounit 2, the blocking part 2a corresponds to multiple first nanounits 2, and the multiple blocking parts 2a are arranged around the first nanounit 2 between the first nanounit 2 and the second nanounit 3 to enclose the first nanounit 2.

[0176] In some embodiments, the first substrate 51 is made of glass, polymethyl methacrylate, or plastic.

[0177] Optionally, the material of the second substrate 52 may include glass, polymethyl methacrylate, or plastic.

[0178] Optionally, the material of the third substrate 53 may include glass, polymethyl methacrylate, or plastic.

[0179] The use of glass, polymethyl methacrylate, or plastic materials gives the first substrate 51, the second substrate 52, and the third substrate 53 high transparency, thermal stability, and good mechanical properties, which helps to improve the overall structural stability of the non-invasive detection module 100.

[0180] In some embodiments, the first collimation portion 21 may be etched onto the first substrate 51, or the first collimation portion 21 may be nanoimprinted onto the first substrate 51, or the first collimation portion 21 may be directly written onto the first substrate 51 using a femtosecond laser, or the first collimation portion 21 may be disposed on the first substrate 51 as an independent nano-element.

[0181] Optionally, the first filter portion 22 may be etched onto the first substrate 51, or the first filter portion 22 may be nanoprinted onto the first substrate 51, or the first filter portion 22 may be formed by femtosecond laser direct writing onto the first substrate 51, or the first filter portion 22 may be disposed on the first substrate 51 as an independent nano-element.

[0182] Optionally, the first focusing portion 23 may be etched onto the second substrate 52, or the first focusing portion 23 may be nanoprinted onto the second substrate 52, or the first focusing portion 23 may be formed by femtosecond laser direct writing onto the second substrate 52, or the first focusing portion 23 may be disposed on the second substrate 52 as an independent nano-element.

[0183] Optionally, the second collimation portion 31 may be etched onto the second substrate 52, or the second collimation portion 31 may be nanoimprinted onto the second substrate 52, or the second collimation portion 31 may be formed by femtosecond laser direct writing onto the second substrate 52, or the second collimation portion 31 may be disposed on the second substrate 52 as an independent nano-element.

[0184] Optionally, the second filter portion 32 may be etched onto the second substrate 52, or the second filter portion 32 may be nanoprinted onto the second substrate 52, or the second filter portion 32 may be formed by femtosecond laser direct writing onto the second substrate 52, or the second filter portion 32 may be disposed on the second substrate 52 as an independent nano-element.

[0185] Optionally, the beam-splitting part 33 can be etched onto the second substrate 52, or the beam-splitting part 33 can be nanoprinted onto the second substrate 52, or the beam-splitting part 33 can be directly written onto the second substrate 52 using a femtosecond laser, or the beam-splitting part 33 can be disposed on the second substrate 52 as an independent nano-element.

[0186] Optionally, the second focusing portion 34 may be etched onto the second substrate 52, or the second focusing portion 34 may be nanoprinted onto the second substrate 52, or the second focusing portion 34 may be formed by femtosecond laser direct writing onto the second substrate 52, or the second focusing portion 34 may be disposed on the second substrate 52 as an independent nano-element.

[0187] Optionally, the first deflection portion 35 may be etched onto the first substrate 51, or the first deflection portion 35 may be nanoprinted onto the first substrate 51, or the first deflection portion 35 may be formed by femtosecond laser direct writing onto the first substrate 51, or the first deflection portion 35 may be disposed on the first substrate 51 as an independent nano-element.

[0188] Optionally, the first sub-reflective portion 361 may be etched onto the second substrate 52, or the first sub-reflective portion 361 may be nanoimprinted onto the second substrate 52, or the first sub-reflective portion 361 may be formed by femtosecond laser direct writing onto the second substrate 52, or the first sub-reflective portion 361 may be disposed on the second substrate 52 as an independent nano-element.

[0189] Optionally, the second sub-reflective portion 362 may be etched onto the first substrate 51, or the second sub-reflective portion 362 may be nanoimprinted onto the first substrate 51, or the second sub-reflective portion 362 may be formed by femtosecond laser direct writing onto the first substrate 51, or the second sub-reflective portion 362 may be disposed on the first substrate 51 as an independent nano-element.

[0190] Optionally, the second deflection portion 37 may be etched onto the second substrate 52, or the second deflection portion 37 may be nanoprinted onto the second substrate 52, or the second deflection portion 37 may be formed by femtosecond laser direct writing onto the second substrate 52, or the second deflection portion 37 may be disposed on the second substrate 52 as an independent nano-element.

[0191] In other embodiments, the first collimation portion 21 may be etched onto the first substrate 51, or the first collimation portion 21 may be nanoimprinted onto the first substrate 51, or the first collimation portion 21 may be formed by femtosecond laser direct writing onto the first substrate 51, or the first collimation portion 21 may be disposed on the first substrate 51 as an independent nano-element.

[0192] Optionally, the first filter portion 22 may be etched onto the second substrate 52, or the first filter portion 22 may be nanoprinted onto the second substrate 52, or the first filter portion 22 may be formed by femtosecond laser direct writing onto the second substrate 52, or the first filter portion 22 may be disposed on the second substrate 52 as an independent nano-element.

[0193] Optionally, the first focusing portion 23 may be etched onto the third substrate 53, or the first focusing portion 23 may be nanoprinted onto the third substrate 53, or the first focusing portion 23 may be formed by femtosecond laser direct writing onto the third substrate 53, or the first focusing portion 23 may be disposed on the third substrate 53 as an independent nano-element.

[0194] Optionally, the second collimation portion 31 may be etched onto the third substrate 53, or the second collimation portion 31 may be nanoimprinted onto the third substrate 53, or the second collimation portion 31 may be formed by femtosecond laser direct writing onto the third substrate 53, or the second collimation portion 31 may be disposed on the third substrate 53 as an independent nano-element.

[0195] Optionally, the second filter portion 32 may be etched onto the third substrate 53, or the second filter portion 32 may be nanoprinted onto the third substrate 53, or the second filter portion 32 may be formed by femtosecond laser direct writing onto the third substrate 53, or the second filter portion 32 may be disposed on the third substrate 53 as an independent nano-element.

[0196] Optionally, the beam-splitting part 33 can be etched onto the third substrate 53, or the beam-splitting part 33 can be nanoprinted onto the third substrate 53, or the beam-splitting part 33 can be formed by femtosecond laser direct writing onto the third substrate 53, or the beam-splitting part 33 can be disposed on the third substrate 53 as an independent nano-element.

[0197] Optionally, the second focusing portion 34 may be etched onto the second substrate 52, or the second focusing portion 34 may be nanoprinted onto the second substrate 52, or the second focusing portion 34 may be formed by femtosecond laser direct writing onto the second substrate 52, or the second focusing portion 34 may be disposed on the second substrate 52 as an independent nano-element.

[0198] For example, such as Figure 9 As shown, the first collimating part 21 is etched and formed on the first substrate 51, the first filtering part 22 and the second focusing part 34 are both etched and formed on the second substrate 52, and the first focusing part 23, the second collimating part 31, the second filtering part 32, and the beam splitting part 33 are all etched and formed on the third substrate 53. By directly etching the components in the first nanounit 2 and the second nanounit 3 on the first substrate 51, the second substrate 52, and the third substrate 53, the integration of the non-invasive detection module 100 is further improved; at the same time, the assembly process of the non-invasive detection module 100 is simplified. During the assembly process, it is not necessary to adjust the relative positions of the components in the first nanounit 2 and the second nanounit 3, which is beneficial to improving the assembly efficiency of the non-invasive detection module 100.

[0199] As an optional implementation, the passband width of the first filter unit 22 is in the range of 0.1nm to 0.5nm, and the optical density value of the first filter unit 22 is ≥2. For example, the passband width of the first filter unit 22 is 0.1nm, 0.2nm, 0.3nm, 0.4nm, 0.5nm, etc.; the optical density value of the first filter unit 22 is 2, 3, 4, 5, 6, etc.

[0200] That is, the bandwidth of the first filter unit 22 can be 0.1nm to 0.5nm, or the bandwidth of the first filter unit 22 can be 0.1nm to 0.4nm, or the bandwidth of the first filter unit 22 can be 0.1nm to 0.3nm, or the bandwidth of the first filter unit 22 can be 0.1nm to 0.2nm, and so on.

[0201] It is understandable that the optical density value of the first filter unit 22 can be ≥2, or ≥3, or ≥4, or ≥5, or ≥6, etc. That is, the optical density value of the first filter unit can be between 2 and 5, or between 2 and 6.

[0202] By utilizing the bandwidth of the first filter section 22, the width of the characteristic peaks of the Raman scattering signal 12 can be reduced, thereby preventing the Raman peaks of the target substance from overlapping with those of other substances. This helps avoid erroneous detection results and further improves the detection accuracy of the non-invasive detection module 100. Furthermore, setting the optical density value of the first filter section 22 to ≥2 effectively prevents light of other wavelengths from passing through it, thus avoiding interference from other wavelengths and preventing erroneous detection results.

[0203] As an optional implementation, the band-stop range of the second filter 32 at least covers the wavelength portion of the light wave 11. This implementation isolates the light wave 11 emitted by the light emitter 1, preventing it from being focused onto the light receiver 4 by the second focusing section 34 and causing erroneous detection results. This further improves the detection accuracy of the non-invasive detection module 100.

[0204] As an optional implementation, the first nanounit 2 can be configured as multiple arranged V-shaped structures, nanocylindrical structures, nanorod antenna structures, nanorectangular structures, nanosheet structures, etc. This embodiment does not limit this.

[0205] Optionally, the second nanounit 3 can be configured as multiple arranged V-shaped structures, nanocylindrical structures, nanorod antenna structures, nanorectangular structures, nanosheet structures, etc. This embodiment does not limit this.

[0206] Optionally, the first collimating section 21 includes a plurality of arranged nanocylindrical structures (not shown), the base radius r and height h of the nanocylindrical structures being less than 500 nm. By designing the values ​​of the base radius r and height h, the angle of incident light phase deflection from 0 to 2π can be adjusted; and by designing the planar arrangement of the nanocylindrical structures, the first collimating section 21 can achieve collimation function.

[0207] Optionally, the first filter section 22 includes multiple stacked nanometer-thick film layers (not shown). (By design (HL)) n (HL) m Multilayer nano-thickness film layers are stacked to enable the first filter section 22 to have an ultra-narrow bandpass filtering function.

[0208] Optionally, the first focusing part 23 includes a plurality of arranged nanocylindrical structures (not shown), the base radius r and height h of the nanocylindrical structures being less than 500 nm. By designing the values ​​of the base radius r and height h, the incident light phase deflection angle from 0 to 2π can be adjusted; and by designing the planar arrangement of the nanocylindrical structures, the first focusing part 23 can achieve focusing functionality.

[0209] Optionally, the second collimator 31 includes a plurality of arranged nanocylindrical structures (not shown), the base radius r and height h of the nanocylindrical structures being less than 500 nm. By designing the values ​​of the base radius r and height h, the incident light phase deflection angle from 0 to 2π can be adjusted; and by designing the planar arrangement of the nanocylindrical structures, the second collimator 31 can achieve collimation function.

[0210] Optionally, the first filter section 22 and the second filter section 32 include multilayered, nano-thickness films. This is achieved through separate design (HL). n (HL) m Multi-nanometer-thickness film layers are stacked to enable the first filter section 22 to have an ultra-narrow bandpass filtering function and the second filter section 32 to have an ultra-narrow bandstop filtering function.

[0211] Optionally, the beam splitter 33 includes multiple arranged nanocylindrical structures (not shown), the base radius r and height h of the nanocylindrical structures being less than 500 nm. By designing the values ​​of the base radius r and height h, the incident light phase deflection angle from 0 to 2π can be adjusted; and by designing the planar arrangement of the nanocylindrical structures, the beam splitter 33 can achieve beam splitting function.

[0212] Optionally, the second focusing section 34 includes a plurality of arranged nanocylindrical structures (not shown), the base radius r and height h of the nanocylindrical structures being less than 500 nm. By designing the values ​​of the base radius r and height h, the incident light phase deflection angle from 0 to 2π can be adjusted; and by designing the planar arrangement of the nanocylindrical structures, the second focusing section 34 can achieve focusing functionality.

[0213] Optionally, the first deflection section 35 includes a plurality of arranged nanocylindrical structures (not shown), the base radius r and height h of the nanocylindrical structures being less than 500 nm. By designing the values ​​of the base radius r and height h, the angle of incident light phase deflection from 0 to 2π can be adjusted; and by designing the planar arrangement of the nanocylindrical structures, the first deflection section 35 can achieve deflection and reflection functions.

[0214] Optionally, the reflective portion 36 includes a plurality of arranged nanocylindrical structures (not shown), the base radius r and height h of the nanocylindrical structures being less than 500 nm. By designing the values ​​of the base radius r and height h, the incident light phase deflection angle from 0 to 2π can be adjusted; and by designing the planar arrangement of the nanocylindrical structures, the reflective portion 36 can achieve a reflective function.

[0215] Optionally, the second deflection section 37 includes a plurality of arranged nanocylindrical structures (not shown), the base radius r and height h of the nanocylindrical structures being less than 500 nm. By designing the values ​​of the base radius r and height h, the angle of incident light phase deflection from 0 to 2π can be adjusted; and by designing the planar arrangement of the nanocylindrical structures, the second deflection section 37 can achieve deflection and reflection functions.

[0216] Optionally, the material of the aforementioned nanocylindrical structure includes titanium dioxide (TiO2), indium tin oxide (ITO), etc., and this embodiment is not limited to this. For example, the nanocylindrical structure is made of TiO2. Because TiO2 has excellent optical properties, chemical stability, and thermal stability, the nanocylindrical structure can achieve effective light absorption and utilization, and has a long service life. Another example is that the nanocylindrical structure is made of ITO. Because ITO has good electro-optical tunability, the photoelectric properties of the nanocylindrical structure can be controlled by an external electric field.

[0217] In some embodiments, such as Figures 7 to 9 As shown, multiple light receivers 4 are arranged around the outer periphery of the light emitter 1. Multiple second nanounits 3 are also arranged around the outer periphery of the first nanounit 2, corresponding to the multiple light receivers 4. The multiple light receivers 4 and multiple second nanounits 3 result in a stronger received Raman scattering signal 12, which helps improve the signal-to-noise ratio of the non-invasive detection module 100, thereby further improving the detection accuracy and precision of the non-invasive detection module 100.

[0218] For example, such as Figure 7 As shown, there are four light receivers 4 arranged around the light emitter 1. The four second nanounits 3 are arranged around the first nanounit 2 on the outer periphery of the first nanounit 2.

[0219] Optionally, the aforementioned optical receiver 4 can be configured as an array-type photodetector, such as a charge-coupled device, a photosensitive chip array, a photodiode array, etc., and this embodiment does not limit this. An array-type photodetector can simultaneously detect multiple optical signals and convert them into electrical signals.

[0220] Please see Figure 10 and Figure 11 , Figure 10 This is a schematic diagram of the structure of the smart device disclosed in the embodiments of this application; Figure 11 This is a schematic diagram of the wearing state of the smart device disclosed in the embodiments of this application. Secondly, the embodiments of this application also disclose a smart device 200, which includes a device body 201 and the non-invasive detection module 100 described in the first aspect, the non-invasive detection module 100 being disposed on the device body 201. The smart device 200 with the non-invasive detection module 100 can also make the size of the non-invasive detection module smaller than that of Raman spectroscopy equipment in related technologies, to meet daily testing needs and make non-invasive testing more convenient and faster.

[0221] In some embodiments, the smart device 200 is configured as a wearable device. For example, the smart device 200 may include a smartwatch, wristband, bracelet, or belt, etc., and this embodiment is not limited thereto. For example, as... Figure 10 and Figure 11 As shown, the smart device 200 is constructed as a smartwatch. By wearing the smartwatch, the concentration of the target substance can be monitored in real time and continuously, making non-invasive detection more convenient and faster.

[0222] Optionally, when a smart device includes a mobile terminal, the mobile terminal may include, but is not limited to, mobile phones, tablets, laptops, in-vehicle computers, walkie-talkies, MP3 players, and MP4 players.

[0223] Taking wearable devices as an example, the main body of the device can be the host part of the wearable device.

[0224] As an optional implementation, the main body 201 includes a control module 2011 and a display module 2012 electrically coupled to the control module 2011. The non-invasive detection module 100 is electrically coupled to the control module 2011. When the non-invasive detection module 100 includes multiple light receivers 4, the main body 201 has a first detection mode and a second detection mode. In the first detection mode, the control module 2011 selects a target signal from the Raman scattering signals output by the multiple light receivers 4, calculates it, and outputs the calculated value so that the display module 2012 displays the detection result of the target signal. In the second detection mode, the control module 2011 superimposes the Raman scattering signals output by the multiple light receivers 4 and outputs the superimposed calculated value so that the display module 2012 displays the superimposed detection result. The target signal is one or more of the strongest signals among the Raman scattering signals. Because it has both a first detection mode and a second detection mode, the intelligent device 200 can select different detection modes according to the actual situation to meet different testing requirements. When the concentration of the target substance is relatively low, the Raman scattering signal is superimposed through the second detection mode to improve the signal-to-noise ratio of the non-invasive detection module 100, thereby improving the detection accuracy of the intelligent device 200 for low-concentration target substances.

[0225] For example, the control module 2011 may include a processor. The control module may be matched with the motherboard of the device body. The device body may be provided with physical buttons or virtual icons that are electrically connected to the control module. Users can control the operation of the non-invasive detection module 100 by clicking the virtual icon or pressing the physical button.

[0226] Please see Figure 12 and Figure 13 , Figure 12 This is a schematic diagram of the first non-invasive detection method disclosed in the embodiments of this application; Figure 13 This is a second schematic diagram of the non-invasive detection method disclosed in the embodiments of this application. Thirdly, the embodiments of this application also disclose a non-invasive detection method, which can be implemented using the intelligent device described in the second aspect above.

[0227] In one implementation, such as Figure 12 As shown, this non-invasive detection method includes the following steps:

[0228] S1. Acquire multiple Raman scattering signals.

[0229] During the non-invasive detection process, the Raman scattering signals can be received by multiple photodetectors 4 on the non-invasive detection module 100, and the received multiple Raman scattering signals can be transmitted to the control module 2011 to complete the acquisition of multiple Raman scattering signals by the intelligent device 200.

[0230] S2. Determine the intensity differences among multiple Raman scattering signals.

[0231] After receiving multiple Raman scattering signals, the control module 2011 performs intensity difference analysis on the multiple Raman scattering signals through the processor. Based on the analysis results, it determines whether the intensity difference between the multiple Raman scattering signals meets the target conditions, and then selects the detection mode.

[0232] For example, the above target conditions include that the intensity difference between multiple Raman scattering signals is within 15%, and the intensity difference δ satisfies: δ=(Max-Min) / Max, where Max is the maximum value among multiple Raman scattering signals, and Min is the minimum value among multiple Raman scattering signals.

[0233] S3. If the intensity difference of multiple Raman scattering signals does not meet the target conditions, the Raman scattering signals are calculated using the first detection mode.

[0234] The first detection mode is a mode that selects the target signal from the Raman scattering signals output by multiple optical receivers for calculation.

[0235] It is understandable that the target signal could be the strongest of multiple Raman scattering signals.

[0236] If the intensity difference analysis results of multiple Raman scattering signals do not meet the target conditions, the processor can choose to calculate the Raman scattering signals in the first detection mode. At this time, the processor compares and filters multiple Raman scattering signals to select the target signal for calculation and outputs the detection results to the display module 2012 for display.

[0237] In another implementation, such as Figure 13 As shown, this non-invasive detection method includes the following steps:

[0238] S1. Acquire multiple Raman scattering signals.

[0239] During the non-invasive detection process, the Raman scattering signals can be received by multiple photodetectors 4 on the non-invasive detection module 100, and the received multiple Raman scattering signals can be transmitted to the control module 2011 to complete the acquisition of multiple Raman scattering signals by the intelligent device 200.

[0240] S2. Determine the intensity differences among multiple Raman scattering signals.

[0241] After receiving multiple Raman scattering signals, the control module 2011 performs intensity difference analysis on the multiple Raman scattering signals through the processor. Based on the analysis results, it determines whether the intensity difference between the multiple Raman scattering signals meets the target conditions, and then selects the detection mode.

[0242] S4. If the intensity difference of multiple Raman scattering signals meets the target condition, the Raman scattering signals are calculated through the second detection mode. The second detection mode is a mode in which the Raman scattering signals output by multiple optical receivers are superimposed for calculation.

[0243] If the intensity difference analysis results of multiple Raman scattering signals meet the target conditions, the processor selects the second detection mode to calculate the Raman scattering signals. At this time, the processor performs superposition processing on multiple Raman scattering signals, performs calculations based on the superimposed signals, and outputs the detection results to the display module 2012 for display.

[0244] It is understandable that these multiple Raman scattering signals are all the received Raman scattering signals.

[0245] For example, when a user activates the smart device 200, the user can change the detection parameters via virtual icons or physical buttons. After confirming the changed parameters, multiple light receivers 4 on the non-invasive detection module 100 begin collecting multiple Raman scattering signals. After collection, the multiple light receivers 4 transmit the multiple Raman scattering signals to the processor of the control module 2011. The processor compares and analyzes the multiple Raman scattering signals with the target range and makes a judgment based on the analysis results. If the intensity difference of the multiple Raman scattering signals does not meet the target conditions, the processor selects the first detection mode to process the Raman scattering signals 12. The processor filters the multiple Raman scattering signals, selects the target signal for calculation, and transmits the calculation result to the display module 2012 for display. If the processor determines that the intensity difference of the multiple Raman scattering signals meets the target conditions, the processor selects the second detection mode to process the multiple Raman scattering signals 12. The processor performs superposition calculation on the multiple Raman scattering signals 12 and transmits the calculation result to the display module 2012 for display.

[0246] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application.

Claims

1. A non-invasive detection module, characterized in that, The non-invasive detection module comprises: a light emitter; a first nano-unit, which is located at a light emitting end of the light emitter, and is configured to focus light waves emitted by the light emitter to a to-be-detected site to excite a Raman scattering signal; a second nano-unit, which is configured to collect the Raman scattering signal; and a light receiver, which is configured to receive the Raman scattering signal collected by the second nano-unit to obtain a Raman spectrum of the to-be-detected site. The first nano-unit comprises a first collimating part, a first filtering part and a first focusing part, which are arranged along the light emitting end of the light emitter, the first collimating part is configured to collimate the light waves, the first filtering part is configured to filter the light waves, and the first focusing part is configured to focus the filtered light waves to the to-be-detected site to excite the Raman scattering signal.

2. The non-invasive detection module of claim 1, wherein, The first focusing part is arranged at a position spaced apart from the first filtering part along an outgoing direction of the light waves.

3. The non-invasive detection module of claim 2, wherein, The first collimating part and the first filtering part are integrally arranged; or The first collimating part and the first filtering part are arranged at positions spaced apart from each other, so that the first filtering part is located between the first collimating part and the first focusing part. The second nano-unit comprises a second collimating part, a second filtering part, a light splitting part and a second focusing part, which are arranged along a transmission direction of the Raman scattering signal, the second collimating part is configured to collimate the Raman scattering signal, the second filtering part is configured to filter the Raman scattering signal, the light splitting part is configured to separate signals of different wavelengths in the filtered Raman scattering signal along a first direction, and the second focusing part is configured to focus signals of the same wavelength to the light receiver.

4. The non-invasive detection module of claim 1, wherein, The first direction is a direction intersecting the direction of the Raman scattering signal. The second focusing part is arranged at a position spaced apart from the light splitting part along the transmission direction of the Raman scattering signal.

5. The non-invasive detection module of claim 4, wherein, At least two of the second collimating part, the second filtering part and the light splitting part are integrally arranged, or the second collimating part, the second filtering part and the light splitting part are sequentially arranged at positions spaced apart from each other along the transmission direction of the Raman scattering signal. The non-invasive detection module further comprises a substrate assembly, which comprises a first substrate, the light emitter and the light receiver are arranged at the first substrate, and the first nano-unit and the second nano-unit are at least partially arranged at the first substrate.

6. The non-invasive detection module of claim 1, wherein, The substrate assembly further comprises a second substrate, which is located at the light emitting end of the light emitter, and the second substrate is arranged at a position spaced apart from the first substrate.

7. The non-invasive detection module of claim 6, wherein, ​ The first nanometer unit comprises a first collimating part, a first filtering part and a first focusing part arranged along an outgoing direction of the light wave, the first collimating part and the first filtering part are arranged on the first substrate and correspond to the light emitter, the first focusing part is arranged on the second substrate and corresponds to the first filtering part, the first collimating part is configured to collimate the light wave, the first filtering part is configured to filter the light wave, and the first focusing part is configured to focus the filtered light wave to the to-be-measured part to excite the Raman scattering signal; The second nanometer unit comprises a second collimating part, a second filtering part, a light splitting part and a second focusing part arranged along a transmission direction of the Raman scattering signal, the second focusing part is arranged on the second substrate and corresponds to the light receiver, and the second focusing part is arranged spaced apart from the first focusing part, the second collimating part, the second filtering part and the light splitting part are arranged on the second substrate and located between the second focusing part and the first focusing part, the second collimating part is configured to collimate the Raman scattering signal, the second filtering part is configured to filter the Raman scattering signal, the light splitting part is configured to separate signals of different wavelengths in the filtered Raman scattering signal along a first direction, and the second focusing part is configured to focus signals of the same wavelength to the light receiver; The first direction is a direction intersecting the transmission direction of the Raman scattering signal.

8. The non-invasive detection module of claim 7, wherein, The first collimating part and the first filtering part are integrally arranged; and / or The second collimating part, the second filtering part and the light splitting part are integrally arranged.

9. The non-invasive detection module of claim 7, wherein, The second nanometer unit further comprises a first deflection part arranged on the first substrate and corresponding to the second collimating part, and the first deflection part is located between the first collimating part and the light receiver, and the first deflection part is configured to reflect the Raman scattering signal at a deflection angle; The reflecting part comprises a first sub-reflection part and a second sub-reflection part, the first sub-reflection part is arranged on the second substrate and located between the light splitting part and the second focusing part, and the second sub-reflection part is arranged on the first substrate and located between the first deflection part and the light receiver; The second deflection part is arranged on the second substrate corresponding to the light receiver, and the second deflection part is arranged upstream of the second focusing part along the transmission direction of the Raman scattering signal, and the second deflection part is configured to reflect the Raman scattering signal at a deflection angle to the second focusing part.

10. The non-invasive detection module of claim 9, wherein, The second deflection part and the second focusing part are integrally arranged; or The second deflection part and the second focusing part are arranged spaced apart.

11. The non-invasive detection module of claim 9, wherein, The reflecting part comprises a plurality of groups, and the plurality of groups of the reflecting part are arranged in sequence between the first deflection part and the second deflection part along a second direction; The second direction is a direction in which the light emitter points to the light receiver.

12. The non-invasive detection module of claim 6, wherein, The substrate assembly further comprises a second substrate and a third substrate, the second substrate and the third substrate are located at the light emitting end of the light emitter, and the first substrate, the second substrate and the third substrate are sequentially arranged along the light wave emission direction. The first nanometer unit comprises a first collimating part, a first filtering part and a first focusing part which are sequentially arranged along the light wave emission direction, the first collimating part is arranged on the first substrate corresponding to the light emitter; the first filtering part is arranged on the second substrate corresponding to the first collimating part; and the first focusing part is arranged on the third substrate corresponding to the first filtering part, the first collimating part is configured to collimate the light wave, the first filtering part is configured to filter the light wave, and the first focusing part is configured to focus the filtered light wave to the to-be-tested part to excite the Raman scattering signal. The second nanometer unit comprises a second collimating part, a second filtering part, a light splitting part and a second focusing part which are sequentially arranged along the transmission direction of the Raman scattering signal, the second collimating part, the second filtering part and the light splitting part are arranged on the first substrate corresponding to the light receiver, and the light splitting part is arranged at intervals with the first focusing part, the second focusing part is arranged on the second substrate corresponding to the light splitting part, and the second focusing part is arranged at intervals with the first filtering part along the transmission direction of the Raman scattering signal, the second collimating part is configured to collimate the Raman scattering signal, the second filtering part is configured to filter the Raman scattering signal, the light splitting part is configured to separate signals of different wavelengths in the filtered Raman scattering signal along a first direction, and the second focusing part is configured to focus signals of the same wavelength to the light receiver. The first direction is a direction intersecting the direction of the Raman scattering signal.

13. The non-invasive detection module of claim 12, wherein, The second collimating part, the second filtering part and the light splitting part are integrally arranged.

14. The non-invasive detection module of claim 7 or 12, wherein, The light receiver and the light emitter are arranged at intervals along a second direction, the interval between the light receiver and the light emitter in the second direction is 200 μm-5 mm; and / or The first nanometer unit and the second nanometer unit are arranged at intervals along a second direction, the interval between the first nanometer unit and the second nanometer unit in the second direction is 200 μm-5 mm; and / or A blocking part is arranged between the first nanometer unit and the second nanometer unit, the blocking part is configured to prevent light reflection from the first nanometer unit to the second nanometer unit. The second direction is the direction in which the light emitter points to the light receiver.

15. The non-invasive detection module of any one of claims 6-13, wherein, The material of the substrate assembly comprises glass, polymethyl methacrylate or plastic; and / or The first nanometer unit and the second nanometer unit are etched on the substrate assembly.

16. The non-invasive detection module of any one of claims 2-3, 7-13, wherein The passband width range of the first filtering part is 0.1 nm-0.5 nm, and the optical density value of the first filtering part is greater than or equal to 2.

17. The non-invasive detection module of any one of claims 4-5, 7-13, wherein The stopband range of the second filtering part covers at least part of the wavelength of the light wave.

18. The non-invasive detection module according to any one of claims 1-13, wherein, the first nano-unit and the second nano-unit comprise a plurality of arranged nano-cylinder structures, the nano-cylinder structures have a bottom surface radius and a height, both of which are less than 500 nm; and / or, the nano-cylinder structures are made of TiO2; and / or, the light wave has a central wavelength of 500 nm-1800 nm; and / or, the light wave has a spectral width of 0.1 nm-50 nm.

19. The non-invasive detection module of any one of claims 1-13, wherein, the light receiver comprises a plurality of light receivers arranged around the light emitter; the second nano-unit corresponding to the plurality of light receivers comprises a plurality of second nano-units arranged around the first nano-unit at the outer periphery of the first nano-unit.

20. A smart device, comprising: The intelligent device comprises a device body and a non-invasive detection module according to any one of claims 1-19, and the non-invasive detection module is arranged on the device body.

21. The smart device of claim 20, wherein, The device body comprises a control module and a display module electrically coupled to the control module, and the non-invasive detection module is electrically coupled to the control module; when the non-invasive detection module comprises a plurality of light receivers, the device body has a first detection mode and a second detection mode; in the first detection mode, the control module selects a target signal in the Raman scattering signals output by the plurality of light receivers for calculation and outputs a calculation value, so that the display module displays the detection result of the target signal; in the second detection mode, the control module superimposes and calculates the Raman scattering signals output by the plurality of light receivers and outputs a superimposed calculation value, so that the display module displays the superimposed detection result; wherein the target signal is one or more signals with the strongest signal in the Raman scattering signals.

22. The smart device of claim 21, wherein, The intelligent device comprises a wearable device.

23. A non-invasive detection method, characterized in that, The non-invasive detection method comprises: obtaining a plurality of Raman scattering signals; judging the intensity difference of the plurality of Raman scattering signals; if the intensity difference of the plurality of Raman scattering signals does not meet the target condition, calculating the Raman scattering signals by a first detection mode; if the intensity difference of the plurality of Raman scattering signals meets the target condition, calculating the Raman scattering signals by a second detection mode; wherein the first detection mode is a mode of selecting a target signal in the Raman scattering signals output by the plurality of light receivers for calculation, and the second detection mode is a mode of superimposing and calculating the Raman scattering signals output by the plurality of light receivers.

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