Essence composition for improving hair health and application thereof

Abstract

The essence composition for improving the hair health is at least prepared from the following raw materials in parts by weight: 0.1 to 5 parts of pyrimidine oxide, 1 to 2 parts of protein hydrolysate, 0.01 to 0.1 part of schizophyllan and 0.1 to 5 parts of hydroxyferriheme. According to the essence composition for improving the hair health, through the synergistic effect of the pyrrolidinyl diaminopyrimidine oxide, the hydrolyzed yeast protein, the hydrolyzed corn protein and the schizophyllan, the health of hair and scalp can be improved, and the essence composition almost has no irritation to the scalp in the using process and does not have the problems of itching, redness and swelling. Diguanidine tetraphosphate extracted from natural extract polar plankton is introduced, so that infiltration of inflammatory cells can be reduced, growth of bacteria and fungi can be controlled, anti-inflammatory and anti-pruritus effects can be effectively achieved, infection can be effectively prevented, and collagen deposition can be increased.

Description

Technical Field

[0001] This invention relates to an essence composition for improving hair health, specifically to A61K, and more particularly to the field of formulations for medical, dental, or cosmetic use. Background Technology

[0002] Hair is primarily composed of insoluble proteins. Each hair has a cylindrical shaft and a root, both growing within a hair follicle composed of connective tissue. The root is the embedded part of the hair, extending from its base into the hair bulb. Hair-producing cells grow within the bulb of the hair follicle and are extruded as fibers as the cells proliferate in the follicle. Blood vessels provide nutrients to the cells. The shaft is the portion of the hair extending from the skin surface. Hair health is characterized by its thickness and color. Normal hair includes three phases: anagen (growth) and telogen (resting). Prolonging the anagen and telogen phases and shortening the telogen phase can reduce hair loss, increase hair density, and improve hair health. Currently available hair growth products can irritate the scalp, causing itching and redness. Furthermore, most hair growth products use herbal extracts, and due to limitations in purification concentration and processing methods, their effectiveness is not significant, requiring long-term use and potentially causing side effects.

[0003] Chinese invention patent CN201810128824.5 discloses a pyrrolidinyl diaminopyrimidine oxide β-cyclodextrin-based inclusion complex and its preparation method. By using β-cyclodextrin to encapsulate the pyrrolidinyl diaminopyrimidine oxide, the water solubility of the pyrimidine oxide can be improved, enhancing product stability without introducing ethanol. However, the product requires the introduction of acids, alkalis, and preservatives, resulting in significant scalp irritation during use. Chinese invention patent CN202210040937.6 discloses an anti-hair loss and hair growth composition and its preparation method, which can effectively replenish scalp nutrients, regulate scalp cell vitality, and promote hair growth. However, the proteins contained in the raw materials are collagen or placental extracts, which have large molecular weights and are not easily absorbed by scalp cells, leading to nutrient loss and insignificant hair growth effects. Summary of the Invention

[0004] In order to improve the hair growth effect of the hair growth essence composition and improve the health of the scalp and hair, the first aspect of this application provides an essence composition for improving hair health, wherein the raw materials include at least the following by weight: 0.1-5 parts of pyrimidine oxide, 1-2 parts of hydrolyzed protein, 0.01-0.1 parts of schistosome, and 0.1-5 parts of hydroxyheme.

[0005] In a preferred embodiment, the pyrimidine oxide is an aminopyrimidine oxide. Preferably, the mass fraction of the pyrrolidinyl diaminopyrimidine oxide in the aminopyrimidine oxide is 50-60%, and the pyrrolidinyl diaminopyrimidine oxide is 6-pyrrolidinyl 2,4-diaminopyrimidine 3-oxide.

[0006] In a preferred embodiment, the hydrolyzed protein is selected from one or a combination of several of hydrolyzed wheat protein, hydrolyzed corn protein, hydrolyzed collagen protein, hydrolyzed yeast protein, hydrolyzed silk protein, and hydrolyzed keratin.

[0007] In a preferred embodiment, the hydrolyzed protein includes hydrolyzed corn protein and hydrolyzed yeast protein.

[0008] In a preferred embodiment, the weight ratio of hydrolyzed corn protein to hydrolyzed yeast protein is (0.5-1):(0.5-1). By employing a preferred combination of hydrolyzed proteins, the expression of P53 and Ki-67 in cells is enhanced, which contributes to hair regeneration and strong anchoring of hair roots, achieving the technical effect of preventing hair loss and maintaining hair density and thickness. The applicant further discovered that it can maintain the growth phase of the hair cycle and slow down the entry into the resting phase, further strengthening the technical effect of preventing hair loss.

[0009] In a preferred embodiment, the hydrolyzed yeast protein is an extract of hydrolyzed protein from Cynodon dactylon and Saccharomyces cerevisiae.

[0010] During the experiment, the applicant discovered that a combination of pyrrolidine diaminopyrimidine oxide, hydrolyzed yeast protein, hydrolyzed corn protein, and schistosome extract can improve hair and scalp health, with minimal irritation to the scalp during use, and no itching or redness. The speculated reason is that pyrrolidine diaminopyrimidine oxide can dilate blood vessels, allowing small-molecule nutrients such as hydrolyzed yeast protein, hydrolyzed corn protein, and schistosome extract to penetrate the scalp, prolonging the growth and regrowth phases of the hair and increasing the supply of nutrients and oxygen to the roots. The nutrients in hydrolyzed yeast protein, hydrolyzed corn protein, and schistosome extract contain adhesion proteins and fibronectin, which, after entering scalp cells, can optimize cell-cell and cell-matrix adhesion, promoting hair follicle differentiation and proliferation, and thus hair regeneration. Simultaneously, pyrrolidine diaminopyrimidine oxide, acting as a potassium channel opener, can promote dermal cell proliferation, transforming resting follicles into anagen follicles, thereby effectively increasing new hair growth and preventing hair loss. The synergistic effect between pyrrolidine diaminopyrimidine oxide, hydrolyzed yeast protein, hydrolyzed corn protein, and schistosome occurs through intercellular interactions. The raw materials and reaction mechanisms are consistent with human functions, thus causing almost no irritation and greatly improving the user experience of the composition.

[0011] In a preferred embodiment, the hydroxyheme contains one or a combination of two of 3-[18-(2-carboxyethyl)-7,12-bis(vinyl)-3,8,13,17-tetramethylporphyrin-21,24-digrin-2-yl]propionate or 3-[18-(2-carboxyethyl)-8,13-bis(vinyl)-3,7,12,17-tetramethylporphyrin-21,24-digrin-2-yl]propionate.

[0012] By introducing hydroxyheme containing 3-[18-(2-carboxyethyl)-7,12-bis(vinyl)-3,8,13,17-tetramethylporphyrin-21,24-diglycoside-2-yl]propionate, porphyrin synthesis can be inhibited, globin synthesis can be stimulated, the water content in the stratum corneum can be increased, transepidermal water loss can be inhibited, and a film can be formed on the hair surface to protect it from the effects of ultraviolet rays and adverse environmental conditions, making the hair surface smooth and shiny, and improving scalp health.

[0013] In a preferred embodiment, the raw materials for preparing the essence composition further include, by weight: 1-3 parts guanidine phosphate, 1-3 parts amino acids, 0.1-2 parts biotin, 5-10 parts chitosan, and 2-6 parts humectant.

[0014] In a preferred embodiment, the chitosan is carboxymethyl chitosan.

[0015] In a preferred embodiment, the biotin is vitamin H.

[0016] In a preferred embodiment, the amino acid is selected from one or a combination of glutamic acid, glycine, and arginine.

[0017] In a preferred embodiment, the amino acid is arginine, and more preferably L-arginine.

[0018] In a preferred embodiment, the moisturizer is selected from one or a combination of panthenol, ceramide, and natural moisturizing factors.

[0019] In a preferred embodiment, the humectant is D-panthenol.

[0020] In a preferred embodiment, the guanidine phosphate is selected from either a natural extract or a synthetically produced one, wherein the natural extract is a polar planktonic extract.

[0021] In a preferred embodiment, the guanidine base phosphate is diguanidine base tetraphosphate.

[0022] By adding diguanidine tetraphosphate and other ingredients, the effective blood circulation of hair follicle cells is increased, the hair growth cycle is prolonged, and the effective supply of nutrients and energy enables hair to regenerate in large quantities. The scalp blood vessel cells increase, fibroblasts are activated, and the collagen arrangement in the dermal tissue is changed, which greatly improves scalp health.

[0023] As a preferred implementation method, The second aspect of this application provides an application of an essence composition for improving hair health, used in hair growth products, including but not limited to hair growth liquids, hair growth creams, hair growth sprays, and hair growth shampoos.

[0024] Compared with the prior art, this application has the following beneficial effects: (1) The hair health improvement essence composition described in this application can improve the health of hair and scalp through the synergistic effect of pyrrolidine diaminopyrimidine oxide, hydrolyzed yeast protein, hydrolyzed corn protein and schizotypalin, and has almost no irritation to the scalp during use, and will not cause itching or redness.

[0025] (2) The hair health improvement essence composition described in this application can reduce the infiltration of inflammatory cells, control the growth of bacteria and fungi by introducing diguanidine tetraphosphate extracted from natural extracts of polar plankton, and can effectively play an anti-inflammatory and anti-itch role, promote effective prevention of infection, and increase collagen deposition.

[0026] (3) The hair health improvement essence composition described in this application, by introducing hydroxyheme containing 3-[18-(2-carboxyethyl)-7,12-bis(vinyl)-3,8,13,17-tetramethylporphyrin-21,24-diglycoside-2-yl]propionate, can inhibit porphyrin synthesis and stimulate globin synthesis, increase the water content in the stratum corneum, inhibit transepidermal water loss, form a film on the hair surface to protect it from the effects of ultraviolet rays and adverse environmental conditions, make the hair surface smooth and shiny, and improve scalp health.

[0027] (4) The hair health improvement essence composition described in this application can be made to have good solubility in solvents through the modification of raw materials. The combination of hydrolyzed corn protein and hydrolyzed yeast protein can improve the stability of hydrolyzed corn protein in low temperature environment, so that it can exist stably. Detailed Implementation

[0028] Example 1 An essence composition for improving hair health, comprising, by weight, at least: 0.1 parts pyrimidine oxide, 1 part hydrolyzed protein, 0.05 parts schizotypalin, 0.2 parts hydroxyheme, 2 parts guanidine phosphate, 1.6 parts amino acids, 0.1 parts biotin, 6 parts chitosan, and 4 parts moisturizer.

[0029] The pyrimidine oxide is an aminopyrimidine oxide, wherein the mass fraction of 6-pyrrolidinyl 2,4-diaminopyrimidine 3-oxide is 50-60%, and it was purchased from Chongqing Donghuan Technology Development Co., Ltd.

[0030] The hydrolyzed protein is hydrolyzed corn protein and hydrolyzed yeast protein in a weight ratio of 0.5:0.5.

[0031] The hydroxyheme contains 3-[18-(2-carboxyethyl)-7,12-bis(vinyl)-3,8,13,17-tetramethylporphyrin-21,24-diglycoside-2-yl]propionate, purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.

[0032] The moisturizer is D-panthenol; the chitosan is carboxymethyl chitosan; the biotin is vitamin H; and the amino acid is L-arginine.

[0033] Example 2 An essence composition for improving hair health, with the same steps as in Example 1, except that the composition includes 3 parts guanidine phosphate, 4 parts amino acids, 0.8 parts biotin, 2 parts chitosan, and 1 part moisturizer.

[0034] Example 3 A hair health-improving essence composition, with the same steps as in Example 1, except that the hydrolyzed protein is hydrolyzed corn protein and hydrolyzed yeast protein in a weight ratio of 0.8:0.2. Performance testing 1. The essence compositions prepared in Examples 1-3 were added to a solvent (water, silicone oil) at a weight ratio of 1:3. The solubility of the compositions was then tested.

[0035] 2. The essence compositions prepared in Examples 1-3 were mixed with water as a solvent, with a weight ratio of essence composition to solvent of 1:3. The mixtures were then allowed to stand at 45°C, 25°C, and 0°C for 72 hours to observe whether any layering occurred.

[0036] The test results are shown in Table 1.

[0037] Table 1

Claims

1. A serum composition for improving hair health, characterized in that, The raw materials for preparation include at least the following by weight: 0.1-5 parts of pyrimidine oxide, 1-2 parts of hydrolyzed protein, 0.01-0.1 parts of schistosome, and 0.1-5 parts of hydroxyheme.

2. The hair health-improving essence composition according to claim 1, characterized in that, The pyrimidine oxide is an aminopyrimidine oxide. Preferably, the mass fraction of the pyrrolidinyl diaminopyrimidine oxide in the aminopyrimidine oxide is 50-60%, and the pyrrolidinyl diaminopyrimidine oxide is 6-pyrrolidinyl 2,4-diaminopyrimidine 3-oxide.

3. The hair health-improving essence composition according to claim 1, characterized in that, The hydrolyzed protein is selected from one or a combination of several of hydrolyzed wheat protein, hydrolyzed corn protein, hydrolyzed collagen protein, hydrolyzed yeast protein, hydrolyzed silk protein, and hydrolyzed keratin.

4. The hair health-improving essence composition according to claim 1, characterized in that, The hydrolyzed yeast protein is an extract of hydrolyzed protein from Cynodon dactylon and Saccharomyces cerevisiae.

5. The hair health-improving essence composition according to claim 1, characterized in that, The hydroxyheme contains one or a combination of two of the following: 3-[18-(2-carboxyethyl)-7,12-bis(vinyl)-3,8,13,17-tetramethylporphyrin-21,24-digelo-2-yl]propionate or 3-[18-(2-carboxyethyl)-8,13-bis(vinyl)-3,7,12,17-tetramethylporphyrin-21,24-digelo-2-yl]propionate.

6. The hair health-improving essence composition according to claim 1, characterized in that, The raw materials for preparing the essence composition also include, by weight: 1-3 parts guanidine phosphate, 1-3 parts amino acids, 0.1-2 parts biotin, 5-10 parts chitosan, and 2-6 parts moisturizer.

7. The hair health-improving essence composition according to claim 1, characterized in that, The amino acid is selected from one or a combination of glutamic acid, glycine, and arginine.

8. The hair health-improving essence composition according to claim 1, characterized in that, The moisturizer is selected from one or a combination of panthenol, ceramide, and natural moisturizing factors.

9. The hair health-improving essence composition according to claim 1, characterized in that, The guanidine phosphate is selected from either a natural extract or a synthetically produced one, wherein the natural extract is a polar planktonic extract.

10. The application of an essence composition for improving hair health according to any one of claims 1-9, characterized in that, It is used in hair growth products.

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