Preparation method of eye herbal gel with eye care function

Abstract

The invention discloses a preparation method of eye herbal gel with an eye nursing function, and particularly relates to a medical nursing material. The preparation method comprises the following steps: preparing the carbomer matrix by using 60% deionized water under homogeneous shearing at the temperature of 5-25 DEG C and the speed of 400-500rpm; preparing a water phase and adding arginine to prepare a neutralization phase; then heating the carbomer matrix to 30-35 DEG C, adding the neutralizing phase, stirring at the rotating speed of 200-300rpm, and then adjusting the pH value to 5.8-6.0 to form transparent gel; pre-emulsifying the xanthophyll, cooling the gel to 25-30 DEG C, and then adding sodium hyaluronate, a fat-soluble component and a xanthophyll fat-soluble phase; and defoaming under vacuum of-0.08 to-0.09 MPa, and finally adding phenoxyethanol-methylparaben as a preservative. According to the method, the problems of caking and non-uniform dispersion are solved through phase separation, low temperature and pre-emulsification processes, and the biological activity of active ingredients is reserved. The product can relieve asthenopia, astigmatism and blurred vision.

Description

Technical Field

[0001] This invention relates to medical care materials, and specifically to a method for preparing an eye herbal gel with eye care functions. Background Technology

[0002] With the significant increase in screen time and the aggravation of environmental pollution, modern people generally face problems such as eye fatigue, dryness, blurred vision, and even early decline in visual function. As one of the thinnest and most sensitive areas of the human body, the skin around the eyes is more susceptible to external stimuli and shows signs of aging. Therefore, the market demand for safe, effective, and soothing eye care products is increasingly urgent. Currently, there are many types of eye care products on the market, but they still have many limitations: for example, some product formulas have unevenly dispersed fat-soluble active ingredients such as lutein, which are prone to precipitation and layering, affecting product stability and user experience; high-temperature and high-speed shearing operations in conventional manufacturing processes can easily destroy the bioactivity of heat-sensitive herbal extracts, leading to reduced product efficacy; in addition, residual air bubbles and improper pH control in the system can also cause product appearance defects and eye irritation, making them particularly unsuitable for long-term use in sensitive areas.

[0003] To address the aforementioned industry pain points, this invention provides a method for preparing an herbal eye gel with eye care functions. Through a series of innovative processes, including low-temperature dispersion, multiphase stepwise mixing, pre-emulsification of lipid-soluble components, precise pH control, and vacuum degassing, the stability, uniformity, and safety of the product are significantly improved. The embodiments demonstrate that this method not only effectively solves common industry technical challenges such as the dispersion of lipid-soluble components, the retention of the activity of heat-sensitive substances, and the control of air bubbles in the system, but also allows for flexible adjustment of the active ingredient combination according to different visual health needs, such as eye fatigue and astigmatism. This provides a reliable path for developing eye care products with differentiated efficacy and market adaptability, demonstrating good industrialization prospects and application value. Summary of the Invention

[0004] To overcome the above-mentioned defects of the prior art, embodiments of the present invention provide a method for preparing an eye herbal gel with eye care function, which solves the problems of product stability, uniformity, poor dispersibility of fat-soluble components, difficulty in retaining the activity of heat-sensitive substances, and difficulty in controlling bubbles in the system.

[0005] To achieve the above objectives, the present invention provides the following technical solution:

[0006] A method for preparing an eye herbal gel with eye care function, specifically including the following steps:

[0007] S1: Add 60% of the total water volume of deionized water to the main dispersion pot, control the temperature, and uniformly add carbomer powder under the shearing of a homogenizer, and continue to shear and disperse until the carbomer is completely swollen and the system is a homogeneous, transparent, particle-free viscous liquid.

[0008] S2: Take another container, add the remaining deionized water, then add butanediol, p-hydroxyacetophenone and water-soluble plant extract in sequence, and stir until completely dissolved and homogeneous to obtain the aqueous phase;

[0009] S3: Add arginine to the aqueous phase obtained in S2 and stir to form a paste-like neutralized phase;

[0010] S4: Heat the carbomer matrix prepared in S1, and add the neutralized phase prepared in S3 to the carbomer matrix under paddle stirring. Stir evenly to thicken the system and form a transparent gel. Monitor the pH with a precision pH meter and finally adjust the pH.

[0011] S5: Pre-emulsify 1 part lutein and 1 part butylene glycol in a small homogenizer to fully disperse them and obtain a homogeneous lipid-soluble phase. Then, cool the gel matrix obtained in S4 through a cold water bath. Subsequently, add sodium hyaluronate solution, lipid-soluble plant extract, and lutein lipid-soluble phase in sequence with wall scraping and stirring. Ensure that each component is completely mixed before adding the next one. Keep the system temperature below 30°C throughout this process.

[0012] S6: Transfer the semi-finished product obtained in S5 to a vacuum homogenizer, stir under vacuum to remove air bubbles from the system until the gel is fine and crystal clear, then release the vacuum, stir under normal pressure, and add a preservative solution to ensure that the preservative is evenly distributed in the gel.

[0013] Preferably, the system temperature in S1 is controlled between 5 and 25°C.

[0014] Preferably, in step S1, carbomer powder is added while the mixture is stirred at 400-500 rpm under shearing in a homogenizer, and then continuously sheared and dispersed at 400-500 rpm for 15-20 minutes until the system becomes a homogeneous viscous liquid.

[0015] Preferably, arginine is added to S3 and stirred at a speed of 200-300 rpm until a paste-like neutralized phase is formed.

[0016] Preferably, in step S4, the carbomer matrix is ​​heated to 30–35°C and stirred with a paddle at 200–300 rpm.

[0017] Preferably, in step S4, the mixture is stirred until it thickens to form a transparent gel, and the pH is controlled between 5.8 and 6.0.

[0018] Preferably, in step S5, the gel matrix is ​​cooled to 25–30°C and stirred by scraping at 200–300 rpm.

[0019] Preferably, in step S5, sodium hyaluronate solution, fat-soluble plant extract, and lutein fat-soluble phase are added sequentially, and before adding the latter substance, it is ensured that the former substance has been completely and evenly mixed.

[0020] Preferably, in step S6, the obtained semi-finished product is placed under a vacuum of -0.08 to -0.09 MPa and stirred at a stirring speed of 100 to 200 rpm for 5 minutes.

[0021] Preferably, the preservative in S6 is a compound solution of phenoxyethanol and methylparaben. After adding the preservative, the mixture is stirred for 10 minutes at a speed of 100-200 rpm.

[0022] The technical effects and advantages of the present invention regarding a method for preparing an eye herbal gel with eye care function are as follows:

[0023] 1. This invention separates the raw materials into a carbomer matrix phase, an aqueous phase, a neutralization phase, and an active phase, enabling refined operation. Arginine and glycerol are premixed to form a neutralization phase, which solves the problem of local clumping caused by directly adding arginine aqueous solution, making the neutralization reaction milder and more thorough, while also solving the problem of uneven gel system.

[0024] 2. This invention strictly controls the addition temperature of all heat-sensitive active ingredients to below 30°C and proposes a pre-emulsification process for lutein, ensuring the uniform dispersion of fat-soluble components and maximizing the protection of the bioactivity of various extracts.

[0025] 3. This invention, combined with vacuum degassing under low shear force, can remove air bubbles to avoid product appearance defects without damaging the formed three-dimensional network gel structure.

[0026] 4. The invention, by shearing and dispersing carbomer at room temperature, ensures a uniform and particle-free matrix while avoiding the denaturation of the colloidal structure caused by high temperature.

[0027] 5. This invention pre-emulsifies lutein with butylene glycol to ensure uniform dispersion of fat-soluble active ingredients in aqueous gels, solving problems such as oil droplets, particles, or precipitation, and addressing the issue of uneven dispersion of fat-soluble ingredients in gels.

[0028] 6. This invention sets the pH of the gel at 5.8 to 6.0, making the product gentle, skin-friendly, and more suitable for sensitive areas around the eyes. Attached Figure Description

[0029] Figure 1 This is a flowchart of a method for preparing an eye herbal gel with eye care function proposed in this invention. Detailed Implementation

[0030] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0031] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0032] Example 1

[0033] This embodiment provides a method for preparing an eye herbal gel with eye care function, the specific implementation steps of which include:

[0034] Experimental materials:

[0035] Main ingredients: 81.7 parts by weight water, 5.0 parts by weight butylene glycol, 0.5 parts by weight p-hydroxyacetophenone, 0.5 parts by weight ginseng extract, 0.4 parts by weight chuanxiong extract, 0.8 parts by weight wild chrysanthemum extract, 0.5 parts by weight wolfberry extract, 0.4 parts by weight angelica extract, 0.3 parts by weight saffron extract, 0.5 parts by weight carbomer, 0.4 parts by weight arginine, 0.8 parts by weight centella asiatica extract, 5.0 parts by weight sodium hyaluronate, 0.5 parts by weight cactus extract, 0.5 parts by weight oat extract, 0.4 parts by weight poria cocos extract, 0.5 parts by weight aloe vera extract, 0.4 parts by weight physalis extract;

[0036] Other trace components: 0.1 parts by weight methylparaben, 0.1 parts by weight lutein, 0.1 parts by weight Polygonum cuspidatum root extract, 0.1 parts by weight Scutellaria baicalensis root extract, 0.1 parts by weight tea extract, 0.1 parts by weight Glycyrrhiza glabra root extract, 0.1 parts by weight Chamomile flower extract, 0.1 parts by weight rosemary leaf extract, 0.1 parts by weight phenoxyethanol.

[0037] Experimental objective:

[0038] Prepare an herbal gel for blurred vision.

[0039] Experimental steps:

[0040] S1: Add 60% of the total water volume of deionized water to the main dispersion pot, control the temperature in the low temperature range of 5-25℃, stir at 500 rpm under the shear of the homogenizer, add carbomer powder evenly, continue shearing and dispersing for 15-20 minutes, and continue shearing and dispersing until the carbomer is completely swollen and the system is a homogeneous, transparent, particle-free viscous liquid.

[0041] S2: Take another container, add the remaining deionized water, then add butanediol, p-hydroxyacetophenone and water-soluble plant extract in sequence, and stir until completely dissolved and homogeneous to obtain the aqueous phase;

[0042] S3: Add arginine to the aqueous phase obtained in S2 and stir to form a paste-like neutralized phase;

[0043] S4: Slowly raise the temperature of the carbomer matrix prepared in S1 to 30-35℃, stir with a paddle at 200 rpm, slowly add the aqueous phase prepared in S3 to the carbomer matrix, stir evenly, so that the system can be rapidly thickened to form a transparent gel, and monitor with a precision pH meter to accurately adjust the final pH value to a slightly acidic 5.8-6.0.

[0044] S5: Pre-emulsify 1 part lutein and 1 part butylene glycol in a small homogenizer to fully disperse them and obtain a homogeneous lipid-soluble phase. Then, cool the gel matrix obtained in S4 to 25-30℃ in a cold water bath. Subsequently, add sodium hyaluronate solution, lipid-soluble plant extract and lutein lipid-soluble phase in sequence with wall scraping and stirring. Ensure that each component is completely mixed before adding the next one. Keep the system temperature below 30℃ throughout this process.

[0045] S6: Transfer the semi-finished product obtained in S5 to a vacuum homogenizer. Under a vacuum of -0.08 to -0.09 MPa, stir to remove air bubbles from the system for 5 minutes until the gel is fine and crystal clear. Then release the vacuum, stir under normal pressure, and slowly add the preservative solution composed of phenoxyethanol and methylparaben. Continue stirring for 10 minutes to ensure that the preservative is evenly distributed in the gel.

[0046] Experimental results: See Table 1 for details.

[0047] Table 1: Test Results of Example 1

[0048]

[0049] Example 1 uses optimized process parameters and a targeted combination of active ingredients such as extracts of Ligusticum chuanxiong, Chrysanthemum indicum, and Lycium barbarum to prepare a gel with a delicate texture and excellent stability. It aims to relieve symptoms such as eye fatigue and blurred vision by promoting microcirculation in the eye and providing antioxidant effects.

[0050] Example 2

[0051] This embodiment provides a method for preparing an eye herbal gel with eye care functions, using different plant extracts to address astigmatism-related double vision and blurred vision. Specific implementation steps include:

[0052] Experimental materials:

[0053] Main ingredients: 82.8 parts by weight water, 5.0 parts by weight butylene glycol, 0.5 parts by weight p-hydroxyacetophenone, 0.5 parts by weight ginseng extract, 0.4 parts by weight Panax notoginseng root extract, 0.3 parts by weight Cuscuta chinensis seed extract, 0.4 parts by weight Taraxacum mongolicum root extract, 0.2 parts by weight peppermint extract, 0.5 parts by weight carbomer, 0.4 parts by weight arginine, 0.8 parts by weight Centella asiatica extract, 5.0 parts by weight sodium hyaluronate, 0.5 parts by weight cactus extract, 0.5 parts by weight oat extract, 0.4 parts by weight Poria cocos extract, 0.5 parts by weight Aloe vera extract, 0.4 parts by weight Hydrangea macrophylla extract;

[0054] Other trace components: 0.1 parts by weight methylparaben, 0.1 parts by weight lutein, 0.1 parts by weight Polygonum cuspidatum root extract, 0.1 parts by weight Scutellaria baicalensis root extract, 0.1 parts by weight tea extract, 0.1 parts by weight Glycyrrhiza glabra root extract, 0.1 parts by weight Chamomile flower extract, 0.1 parts by weight rosemary leaf extract, 0.1 parts by weight phenoxyethanol.

[0055] Experimental objective:

[0056] A gel for treating astigmatism, causing double vision and blurred vision.

[0057] Experimental steps:

[0058] S1: Add 60% of the total water volume of deionized water to the main dispersion vessel, control the temperature in the low temperature range of 5-25℃, stir at 500 rpm under the shear of a homogenizer, add carbomer powder evenly, continue shearing and dispersing for 15-20 minutes, and continue shearing and dispersing until the carbomer is completely swollen and the system is a homogeneous, transparent, particle-free viscous liquid.

[0059] S2: Take another container, add the remaining deionized water, then add butanediol, p-hydroxyacetophenone and water-soluble plant extract in sequence, and stir until completely dissolved and homogeneous to obtain the aqueous phase;

[0060] S3: Add arginine to the aqueous phase obtained in S2 and stir to form a paste-like neutralized phase;

[0061] S4: Slowly raise the temperature of the carbomer matrix prepared in S1 to 30-35℃, stir with a paddle at 200 rpm, slowly add the aqueous phase prepared in S3 to the carbomer matrix, stir evenly, so that the system can be rapidly thickened to form a transparent gel, and monitor with a precision pH meter to accurately adjust the final pH value to a slightly acidic 5.8-6.0.

[0062] S5: Pre-emulsify 1 part lutein and 1 part butylene glycol in a small homogenizer to fully disperse them and obtain a homogeneous lipid-soluble phase. Then, cool the gel matrix obtained in S4 to 25-30℃ in a cold water bath. Subsequently, add sodium hyaluronate solution, lipid-soluble plant extract, and lutein lipid-soluble phase in sequence with wall scraping and stirring. Ensure that each component is completely mixed before adding the next one. Keep the system temperature below 30℃ throughout this process.

[0063] S6: Transfer the semi-finished product obtained in S5 to a vacuum homogenizer. Under a vacuum of -0.08 to -0.09 MPa, stir to remove air bubbles from the system for 5 minutes until the gel is fine and crystal clear. Then release the vacuum, stir under normal pressure, and slowly add the preservative solution composed of phenoxyethanol and methylparaben. Continue stirring for 10 minutes to ensure that the preservative is evenly distributed in the gel.

[0064] Experimental results: See Table 2 for details.

[0065] Table 2: Test Results of Example 2

[0066]

[0067] Example 2, while maintaining the same excellent process and stability as Example 1, adopts another unique plant extract formula, such as Panax notoginseng root, Cuscuta chinensis seed, and Taraxacum mongolicum root. Its formula design focuses more on the theories of improving eyesight and correcting refractive errors in traditional medicine, aiming to specifically alleviate more specific visual impairment problems such as double vision and blurred vision caused by astigmatism.

[0068] Example 3

[0069] This embodiment provides a method for preparing an eye herbal gel with eye care function, which improves the mixing speed of the homogenizer shear machine. The specific implementation steps include:

[0070] Experimental materials:

[0071] Main ingredients: 81.7 parts by weight water, 5.0 parts by weight butylene glycol, 0.5 parts by weight p-hydroxyacetophenone, 0.5 parts by weight ginseng extract, 0.4 parts by weight chuanxiong extract, 0.8 parts by weight wild chrysanthemum extract, 0.5 parts by weight wolfberry extract, 0.4 parts by weight angelica extract, 0.3 parts by weight saffron extract, 0.5 parts by weight carbomer, 0.4 parts by weight arginine, 0.8 parts by weight centella asiatica extract, 5.0 parts by weight sodium hyaluronate, 0.5 parts by weight cactus extract, 0.5 parts by weight oat extract, 0.4 parts by weight poria cocos extract, 0.5 parts by weight aloe vera extract, 0.4 parts by weight physalis extract;

[0072] Other trace components: 0.1 parts by weight methylparaben, 0.1 parts by weight lutein, 0.1 parts by weight Polygonum cuspidatum root extract, 0.1 parts by weight Scutellaria baicalensis root extract, 0.1 parts by weight tea extract, 0.1 parts by weight Glycyrrhiza glabra root extract, 0.1 parts by weight Chamomile flower extract, 0.1 parts by weight rosemary leaf extract, 0.1 parts by weight phenoxyethanol.

[0073] Experimental objective:

[0074] Prepare an herbal gel for blurred vision.

[0075] Experimental steps:

[0076] S1: Add 60% of the total water volume of deionized water to the main dispersion vessel, control the temperature in the low temperature range of 5-25℃, stir at 1000 rpm under the shear of the homogenizer, add carbomer powder evenly, continue shearing and dispersing for 15-20 minutes, and continue shearing and dispersing until the carbomer is completely swollen and the system is a homogeneous, transparent, particle-free viscous liquid.

[0077] S2: Take another container, add the remaining deionized water, then add butanediol, p-hydroxyacetophenone and water-soluble plant extract in sequence, and stir until completely dissolved and homogeneous to obtain the aqueous phase;

[0078] S3: Add arginine to the aqueous phase obtained in S2 and stir to form a paste-like neutralized phase;

[0079] S4: Slowly raise the temperature of the carbomer matrix prepared in S1 to 30-35℃, stir with a paddle at 200 rpm, slowly add the aqueous phase prepared in S3 to the carbomer matrix, stir evenly, so that the system can be rapidly thickened to form a transparent gel, and monitor with a precision pH meter to accurately adjust the final pH value to a slightly acidic 5.8-6.0.

[0080] S5: Pre-emulsify 1 part lutein and 1 part butylene glycol in a small homogenizer to fully disperse them and obtain a homogeneous lipid-soluble phase. Then, cool the gel matrix obtained in S4 to 25-30℃ in a cold water bath. Subsequently, add sodium hyaluronate solution, lipid-soluble plant extract, and lutein lipid-soluble phase in sequence with wall scraping and stirring. Ensure that each component is completely mixed before adding the next one. Keep the system temperature below 30℃ throughout this process.

[0081] S6: Transfer the semi-finished product obtained in S5 to a vacuum homogenizer. Under a vacuum of -0.08 to -0.09 MPa, stir to remove air bubbles from the system for 5 minutes until the gel is fine and crystal clear. Then release the vacuum, stir under normal pressure, and slowly add the preservative solution composed of phenoxyethanol and methylparaben. Continue stirring for 10 minutes to ensure that the preservative is evenly distributed in the gel.

[0082] Experimental results: See Table 3 for details.

[0083] Table 3: Test Results of Example 3

[0084]

[0085] Example 3 investigated the effect of process parameters by increasing the shear speed of the homogenizer to 1000 rpm. The results showed that high-speed shearing destroyed the three-dimensional network structure of the gel, resulting in a significant decrease in viscosity, water separation and a grainy texture, and a significant reduction in stability. This, in turn, confirmed the importance of controlling the shear speed in maintaining the integrity of the gel structure in this invention.

[0086] Example 4

[0087] This embodiment provides a method for preparing an eye herbal gel with eye care function, which involves adjusting the speed of a paddle mixer. Specific implementation steps include:

[0088] Experimental materials:

[0089] Main ingredients: 81.7 parts by weight water, 5.0 parts by weight butylene glycol, 0.5 parts by weight p-hydroxyacetophenone, 0.5 parts by weight ginseng extract, 0.4 parts by weight chuanxiong extract, 0.8 parts by weight wild chrysanthemum extract, 0.5 parts by weight wolfberry extract, 0.4 parts by weight angelica extract, 0.3 parts by weight saffron extract, 0.5 parts by weight carbomer, 0.4 parts by weight arginine, 0.8 parts by weight centella asiatica extract, 5.0 parts by weight sodium hyaluronate, 0.5 parts by weight cactus extract, 0.5 parts by weight oat extract, 0.4 parts by weight poria cocos extract, 0.5 parts by weight aloe vera extract, 0.4 parts by weight physalis extract;

[0090] Other trace components: 0.1 parts by weight methylparaben, 0.1 parts by weight lutein, 0.1 parts by weight Polygonum cuspidatum root extract, 0.1 parts by weight Scutellaria baicalensis root extract, 0.1 parts by weight tea extract, 0.1 parts by weight Glycyrrhiza glabra root extract, 0.1 parts by weight Chamomile flower extract, 0.1 parts by weight rosemary leaf extract, 0.1 parts by weight phenoxyethanol.

[0091] Experimental objective:

[0092] Prepare an herbal gel for blurred vision.

[0093] Experimental steps:

[0094] S1: Add 60% of the total water volume of deionized water to the main dispersion vessel, control the temperature in the low temperature range of 5-25℃, stir at 500 rpm under the shear of a homogenizer, add carbomer powder evenly, continue shearing and dispersing for 15-20 minutes, and continue shearing and dispersing until the carbomer is completely swollen and the system is a homogeneous, transparent, particle-free viscous liquid.

[0095] S2: Take another container, add the remaining deionized water, then add butanediol, p-hydroxyacetophenone and water-soluble plant extract in sequence, and stir until completely dissolved and homogeneous to obtain the aqueous phase;

[0096] S3: Add arginine to the aqueous phase obtained in S2 and stir to form a paste-like neutralized phase;

[0097] S4: Slowly raise the temperature of the carbomer matrix prepared in S1 to 30-35℃, stir with a paddle at 400 rpm, slowly add the aqueous phase prepared in S3 to the carbomer matrix, stir evenly, so that the system can be rapidly thickened to form a transparent gel, and monitor with a precision pH meter to accurately adjust the final pH value to a slightly acidic 5.8-6.0.

[0098] S5: Pre-emulsify 1 part lutein and 1 part butylene glycol in a small homogenizer to fully disperse them and obtain a homogeneous lipid-soluble phase. Then, cool the gel matrix obtained in S4 to 25-30℃ in a cold water bath. Subsequently, add sodium hyaluronate solution, lipid-soluble plant extract, and lutein lipid-soluble phase in sequence with wall scraping and stirring. Ensure that each component is completely mixed before adding the next one. Keep the system temperature below 30℃ throughout this process.

[0099] S6: Transfer the semi-finished product obtained in S5 to a vacuum homogenizer. Under a vacuum of -0.08 to -0.09 MPa, stir to remove air bubbles from the system for 5 minutes until the gel is fine and crystal clear. Then release the vacuum, stir under normal pressure, and slowly add the preservative solution composed of phenoxyethanol and methylparaben. Continue stirring for 10 minutes to ensure that the preservative is evenly distributed in the gel.

[0100] Experimental results: See Table 4 for details.

[0101] Table 4: Test Results of Example 4

[0102]

[0103] Example 4 observed the effect of stirring intensity on the product by increasing the paddle stirring speed to 400 rpm. The results showed that higher speeds introduce micro-bubbles, affecting the uniformity and appearance of the product. Although the main structure was not severely damaged, it still highlighted the necessity of controlling the stirring speed during the neutralization stage to avoid the generation of bubbles.

[0104] Example 5

[0105] This embodiment provides a method for preparing an eye herbal gel with eye care function, reducing the pre-emulsification of fat-soluble active ingredients. The specific implementation steps include:

[0106] Experimental materials:

[0107] Main ingredients: 81.7 parts by weight water, 5.0 parts by weight butylene glycol, 0.5 parts by weight p-hydroxyacetophenone, 0.5 parts by weight ginseng extract, 0.4 parts by weight chuanxiong extract, 0.8 parts by weight wild chrysanthemum extract, 0.5 parts by weight wolfberry extract, 0.4 parts by weight angelica extract, 0.3 parts by weight saffron extract, 0.5 parts by weight carbomer, 0.4 parts by weight arginine, 0.8 parts by weight centella asiatica extract, 5.0 parts by weight sodium hyaluronate, 0.5 parts by weight cactus extract, 0.5 parts by weight oat extract, 0.4 parts by weight poria cocos extract, 0.5 parts by weight aloe vera extract, 0.4 parts by weight physalis extract;

[0108] Other trace components: 0.1 parts by weight methylparaben, 0.1 parts by weight lutein, 0.1 parts by weight Polygonum cuspidatum root extract, 0.1 parts by weight Scutellaria baicalensis root extract, 0.1 parts by weight tea extract, 0.1 parts by weight Glycyrrhiza glabra root extract, 0.1 parts by weight Chamomile flower extract, 0.1 parts by weight rosemary leaf extract, 0.1 parts by weight phenoxyethanol.

[0109] Experimental objective:

[0110] Prepare an herbal gel for blurred vision.

[0111] Experimental steps:

[0112] S1: Add 60% of the total water volume of deionized water to the main dispersion vessel, control the temperature in the low temperature range of 5-25℃, stir at 500 rpm under the shear of a homogenizer, add carbomer powder evenly, continue shearing and dispersing for 15-20 minutes, and continue shearing and dispersing until the carbomer is completely swollen and the system is a homogeneous, transparent, particle-free viscous liquid.

[0113] S2: Take another container, add the remaining deionized water, then add butanediol, p-hydroxyacetophenone and water-soluble plant extract in sequence, and stir until completely dissolved and homogeneous to obtain the aqueous phase;

[0114] S3: Add arginine to the aqueous phase obtained in S2 and stir to form a paste-like neutralized phase;

[0115] S4: Slowly raise the temperature of the carbomer matrix prepared in S1 to 30-35℃, stir with a paddle at 200 rpm, slowly add the aqueous phase prepared in S3 to the carbomer matrix, stir evenly, so that the system can be rapidly thickened to form a transparent gel, and monitor with a precision pH meter to accurately adjust the final pH value to a slightly acidic 5.8-6.0.

[0116] S5: Cool the gel matrix obtained in S4 to 25-30℃ in a cold water bath, and then add sodium hyaluronate solution, fat-soluble plant extract and lutein fat-soluble phase in sequence with wall scraping and stirring. Ensure that each component is completely mixed before adding the next one. Keep the system temperature below 30℃ throughout this process.

[0117] S6: Transfer the semi-finished product obtained in S5 to a vacuum homogenizer. Under a vacuum of -0.08 to -0.09 MPa, stir to remove air bubbles from the system for 5 minutes until the gel is fine and crystal clear. Then release the vacuum, stir under normal pressure, and slowly add the preservative solution composed of phenoxyethanol and methylparaben. Continue stirring for 10 minutes to ensure that the preservative is evenly distributed in the gel.

[0118] Experimental results: See Table 5 for details.

[0119] Table 5: Test Results of Example 5

[0120]

[0121] Example 5, by omitting the pre-emulsification step of lutein and directly adding the fat-soluble component, resulted in uneven phenomena such as oil droplet precipitation and layering during product storage, further verifying the key role of the pre-emulsification process in ensuring uniform dispersion of fat-soluble active ingredients and maintaining product stability.

[0122] Example 1 successfully prepared an eye care gel with a delicate texture and excellent stability by using optimized process parameters and targeted active ingredient combinations, which is suitable for relieving eye fatigue and related visual blurring symptoms.

[0123] Example 2 uses the same rigorous process as Example 1, but adapts another set of active ingredients that focus on correcting refractive errors and alleviating astigmatism. It also achieves high-quality products, demonstrating the good formulation adaptability and application potential of the method of the present invention.

[0124] Example 3 used high-speed homogeneous shearing beyond the recommended range, which led to the destruction of the gel network structure and a decrease in product stability, confirming the importance of controlling the shearing rate for this method.

[0125] Example 4 used excessively high-speed paddle stirring, which introduced air bubbles, affecting the product's appearance and uniformity, thus confirming the necessity of gentle stirring during the neutralization stage.

[0126] Example 5 uses a simplified process that omits pre-emulsification, which results in uneven dispersion of fat-soluble components and precipitation and stratification of the product, highlighting the key role of the pre-emulsification process in ensuring the stability of the system.

[0127] Comparing the various examples, Example 1 achieves the optimal balance in terms of formulation specificity, process stability, and product performance. It cleverly utilizes processes such as low-temperature shearing, phase separation, pre-emulsification, and vacuum degassing to improve the stability, uniformity, and bioavailability of the active ingredients in the gel, making it suitable for daily eye care and relieving eye fatigue and related blurred vision. Although Example 2 uses a different formulation, its rigorous process still ensures high product quality, demonstrating the potential of the method to adapt to different active ingredients to meet diverse care needs, providing a new care solution for double vision caused by astigmatism. Examples 3, 4, and 5, through negative examples, highlight the functional limitations and product defects resulting from deviations from the core process parameters of this invention. Therefore, the preparation method provided by this invention is not only clear in its steps and highly operable, but also, through precise control of key process parameters, effectively guarantees the production of high-quality, highly stable herbal gels with specific eye care functions.

[0128] The above description is merely a specific embodiment of this application, but the scope of protection of this application is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in this application should be included within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of protection of the claims.

[0129] In conclusion, the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A method for preparing an eye herbal gel with eye care function, characterized in that, Specifically, the following steps are included: S1: Add 60% of the total water volume of deionized water to the main dispersion pot, control the temperature, and uniformly add carbomer powder under the shearing of a homogenizer, and continue to shear and disperse until the carbomer is completely swollen and the system is a homogeneous, transparent, particle-free viscous liquid. S2: Take another container, add the remaining deionized water, then add butanediol, p-hydroxyacetophenone and water-soluble plant extract in sequence, and stir until completely dissolved and homogeneous to obtain the aqueous phase; S3: Add arginine to the aqueous phase obtained in S2 and stir to form a paste-like neutralized phase; S4: Heat the carbomer matrix prepared in S1, and add the neutralized phase prepared in S3 to the carbomer matrix under paddle stirring. Stir evenly to thicken the system and form a transparent gel. Monitor the pH with a precision pH meter and finally adjust the pH. S5: Pre-emulsify 1 part lutein and 1 part butylene glycol in a small homogenizer to fully disperse them and obtain a homogeneous lipid-soluble phase. Then, cool the gel matrix obtained in S4 through a cold water bath. Subsequently, add sodium hyaluronate solution, lipid-soluble plant extract and lutein lipid-soluble phase in sequence with wall scraping and stirring. Ensure that each component is completely mixed before adding the next one. Keep the system temperature below 30°C throughout this process. S6: Transfer the semi-finished product obtained in S5 to a vacuum homogenizer, stir under vacuum to remove air bubbles from the system until the gel is fine and crystal clear, then release the vacuum, stir under normal pressure, and add a preservative solution to ensure that the preservative is evenly distributed in the gel.

2. The method for preparing an eye herbal gel with eye care function as described in claim 1, characterized in that, In S1, the system temperature is controlled between 5 and 25°C.

3. The method for preparing an eye-care herbal gel as described in claim 1, characterized in that, In S1, the mixture is stirred at 400-500 rpm under shearing in a homogenizer, and carbomer powder is added. The mixture is then continuously sheared and dispersed at 400-500 rpm for 15-20 minutes until the system becomes a homogeneous viscous liquid.

4. The method for preparing an eye herbal gel with eye care function as described in claim 1, characterized in that, Add arginine to S3 and stir at 200-300 rpm until a paste-like neutralized phase is formed.

5. The method for preparing an eye herbal gel with eye care function as described in claim 1, characterized in that, In S4, the carbomer matrix is ​​heated to 30–35°C and stirred with a paddle at 200–300 rpm.

6. The method for preparing an eye-care herbal gel as described in claim 1, characterized in that, Stir in S4 until the system thickens to form a transparent gel, and control the pH between 5.8 and 6.

0.

7. The method for preparing an eye herbal gel with eye care function as described in claim 1, characterized in that, In S5, the gel matrix is ​​cooled to 25–30°C and stirred by scraping at 200–300 rpm.

8. The method for preparing an eye herbal gel with eye care function as described in claim 1, characterized in that, Add sodium hyaluronate solution, fat-soluble plant extract, and lutein fat-soluble phase to S5 in sequence, and ensure that the previous substance is completely mixed before adding the next substance.

9. The method for preparing an eye herbal gel with eye care function as described in claim 1, characterized in that, In step S6, the obtained semi-finished product is placed under a vacuum of -0.08 to -0.09 MPa and stirred at a stirring speed of 100 to 200 rpm for 5 minutes.

10. The method for preparing an eye herbal gel with eye care function as described in claim 1, characterized in that, The preservative mentioned in S6 is a compound solution of phenoxyethanol and methylparaben. After adding the preservative, continue stirring at a speed of 100-200 rpm for 10 minutes.

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